1) A 15-year-old male presented with a 2-year history of a gradually growing inferior orbital mass on the left lower eyelid and nasal area. Physical examination revealed a firm, movable, painless 3x2 cm mass in that location with redness of the medial left lower eyelid.
2) MRI showed an inferior orbital cyst, with primary consideration being a nasolacrimal duct mucocele.
3) Differential diagnoses included dermoid cyst and dacryocystocele, though the patient's age made these less likely. Nasolacrimal duct mucocele could not be ruled out.
4) Management would involve dacryocystorhinost
Sadia, a 10-year old girl, presented with pain and swelling in her left leg for 3 months and difficulty walking for 1 month. She also had a new painless swelling near her left eye. Initial workup found a mass in her left leg and another in her left eye area. Biopsies of the masses found features suggestive of Ewing sarcoma and metastatic neuroblastoma. Further imaging and testing confirmed the diagnosis of metastatic neuroblastoma with a primary tumor in her left leg and metastases in her left eye area.
This patient presented with a 6 month history of rectal bleeding, loose stools for 2 months, abdominal pain for 20 days, and weight loss of 21 kg over 2 months. A physical exam revealed pallor, abdominal tenderness, oral thrush, and scrotal rash. The differential diagnoses included inflammatory bowel disease, intestinal TB, infective enterocolitis, and malignancy.
Chronic Rhinosinusitis with Nasal Polyposis grade III rightRyanFBernal
This case presentation is for a 17-year-old female who presents with a 10-year history of recurrent nasal congestion, post-nasal drip, anosmia, facial pain and sinus tenderness. Physical examination revealed pale, gray polypoid masses in the nose, graded III on the right and II on the left. The differential diagnoses considered were chronic rhinosinusitis with nasal polyposis, recurrent acute bacterial rhinosinusitis, and sinonasal malignancy. Chronic rhinosinusitis with nasal polyposis was determined to be the most likely diagnosis based on pertinent history and physical examination findings.
This patient presented with new onset right-sided headache, eye redness, and double vision when looking to the right. Physical exam revealed proptosis and injection of both eyes, with greater involvement on the right side. Imaging showed diffuse calcifications in the basal ganglia consistent with Fahr's disease, as well as enlargement and enhancement of the right extraocular muscles, concerning for thyroid orbitopathy. The differential diagnosis included Graves' ophthalmopathy, retroorbital tumor/hematoma, cavernous sinus thrombosis, and migraine. Management focused on treating the thyroid orbitopathy while further evaluating the neurological condition of Fahr's disease.
A 52-year-old female teacher presented with worsening dyspnea over the past two weeks. She initially developed a non-productive cough that progressed to a productive cough with yellow sputum. She also experienced low-grade fever, pleuritic left chest pain, and shortness of breath. On examination, she had decreased breath sounds and dullness to percussion on the left lower lung field. The main impression is pleural effusion secondary to community-acquired pneumonia based on her symptoms of productive cough, fever, pleuritic chest pain, and physical exam findings suggestive of a pleural effusion.
A 65-year-old man presented with a swelling on the left side of his neck for 20 days. On examination, the left upper jugular lymph nodes were enlarged and firm. He reported loss of appetite and weight. The doctor's diagnosis was neck secondaries of unknown primary, likely involving lymph nodes levels 2 and 3. Differential diagnoses included tuberculous lymphadenitis and lymphoma. Investigations such as blood tests, imaging of the neck and chest, and biopsies were planned. The proposed treatment was radiotherapy or radical neck dissection followed by chemotherapy.
A 27-year-old male with bilateral red eyes.pptxAsAadHabib2
The patient presented with bilateral red eyes with chronic discharge from both eyes and a history of chalazion surgery. We did necessary investigations and treated him with topical fortified ceftazidime and systemic antibiotics. But later similar presentations were seen. We again did all the available and necessary investigations yet nothing significant was found. As our country is an endemic zone for TB we started empirical anti TB drugs. The rest is on the presentation.
A 58-year-old male presented with a painless, gradually progressive swelling below his right ear for one year. On examination, he was found to have a solitary, firm to hard, bilobed swelling measuring 8x3cm in the right parotid region. No other abnormalities were noted. The probable diagnosis is a right parotid swelling.
Sadia, a 10-year old girl, presented with pain and swelling in her left leg for 3 months and difficulty walking for 1 month. She also had a new painless swelling near her left eye. Initial workup found a mass in her left leg and another in her left eye area. Biopsies of the masses found features suggestive of Ewing sarcoma and metastatic neuroblastoma. Further imaging and testing confirmed the diagnosis of metastatic neuroblastoma with a primary tumor in her left leg and metastases in her left eye area.
This patient presented with a 6 month history of rectal bleeding, loose stools for 2 months, abdominal pain for 20 days, and weight loss of 21 kg over 2 months. A physical exam revealed pallor, abdominal tenderness, oral thrush, and scrotal rash. The differential diagnoses included inflammatory bowel disease, intestinal TB, infective enterocolitis, and malignancy.
Chronic Rhinosinusitis with Nasal Polyposis grade III rightRyanFBernal
This case presentation is for a 17-year-old female who presents with a 10-year history of recurrent nasal congestion, post-nasal drip, anosmia, facial pain and sinus tenderness. Physical examination revealed pale, gray polypoid masses in the nose, graded III on the right and II on the left. The differential diagnoses considered were chronic rhinosinusitis with nasal polyposis, recurrent acute bacterial rhinosinusitis, and sinonasal malignancy. Chronic rhinosinusitis with nasal polyposis was determined to be the most likely diagnosis based on pertinent history and physical examination findings.
This patient presented with new onset right-sided headache, eye redness, and double vision when looking to the right. Physical exam revealed proptosis and injection of both eyes, with greater involvement on the right side. Imaging showed diffuse calcifications in the basal ganglia consistent with Fahr's disease, as well as enlargement and enhancement of the right extraocular muscles, concerning for thyroid orbitopathy. The differential diagnosis included Graves' ophthalmopathy, retroorbital tumor/hematoma, cavernous sinus thrombosis, and migraine. Management focused on treating the thyroid orbitopathy while further evaluating the neurological condition of Fahr's disease.
A 52-year-old female teacher presented with worsening dyspnea over the past two weeks. She initially developed a non-productive cough that progressed to a productive cough with yellow sputum. She also experienced low-grade fever, pleuritic left chest pain, and shortness of breath. On examination, she had decreased breath sounds and dullness to percussion on the left lower lung field. The main impression is pleural effusion secondary to community-acquired pneumonia based on her symptoms of productive cough, fever, pleuritic chest pain, and physical exam findings suggestive of a pleural effusion.
A 65-year-old man presented with a swelling on the left side of his neck for 20 days. On examination, the left upper jugular lymph nodes were enlarged and firm. He reported loss of appetite and weight. The doctor's diagnosis was neck secondaries of unknown primary, likely involving lymph nodes levels 2 and 3. Differential diagnoses included tuberculous lymphadenitis and lymphoma. Investigations such as blood tests, imaging of the neck and chest, and biopsies were planned. The proposed treatment was radiotherapy or radical neck dissection followed by chemotherapy.
A 27-year-old male with bilateral red eyes.pptxAsAadHabib2
The patient presented with bilateral red eyes with chronic discharge from both eyes and a history of chalazion surgery. We did necessary investigations and treated him with topical fortified ceftazidime and systemic antibiotics. But later similar presentations were seen. We again did all the available and necessary investigations yet nothing significant was found. As our country is an endemic zone for TB we started empirical anti TB drugs. The rest is on the presentation.
A 58-year-old male presented with a painless, gradually progressive swelling below his right ear for one year. On examination, he was found to have a solitary, firm to hard, bilobed swelling measuring 8x3cm in the right parotid region. No other abnormalities were noted. The probable diagnosis is a right parotid swelling.
A 58-year-old male presented with a painless, gradually progressive swelling below his right ear for one year. On examination, he was found to have a solitary, firm-to-hard, bilobed swelling measuring 8x3cm in the right parotid region. All other physical findings were normal. The probable diagnosis is a swelling of the right parotid gland.
A 14-year-old boy presented with difficulty breathing, facial swelling, swelling of both feet, and chest pain for two days. He had a history of a similar episode 8 months prior where he was diagnosed with a heart condition. On examination, he had an irregularly irregular pulse, low blood pressure, visible apex beat, and grade V pansystolic murmurs in the mitral, tricuspid, and pulmonary areas, suggestive of chronic rheumatic heart disease with mitral regurgitation and left ventricular hypertrophy.
The 85-year-old male patient presented with progressive forgetfulness, weight loss, and depressed mood over the past year since his wife's death. His daughter observed a decline in his ability to recall recent events, directions, and names. Alzheimer's disease is the primary consideration given his age and symptoms consistent with typical memory loss and cognitive decline seen in Alzheimer's. Differential diagnoses considered include delirium, depression, and hypothyroidism but were deemed less likely based on aspects of his history and presentation that did not fully match these conditions.
The 85-year-old male patient presented with progressive forgetfulness, weight loss, and depressed mood over the past year since his wife's death. His daughter observed deterioration in his memory, concentration, and ability to carry on conversations. Alzheimer's disease is the primary consideration given his age and symptom progression. Differential diagnoses considered include delirium, depression, and hypothyroidism but were deemed less likely based on aspects of his clinical presentation and history.
1. A 21-year-old female presented with progressive weakness on the right side of her body over 1.5 years, along with fever, headache, diplopia, and two seizures.
2. Neurological examination revealed spastic right hemiparesis, internuclear ophthalmoplegia, nystagmus, and ataxic gait.
3. MRI brain showed multiple enhancing lesions in the midbrain, left periventricular area, and left basal ganglia, suggestive of tuberculomas. She was diagnosed with multiple tuberculomas and treated with anti-tuberculosis therapy and steroids.
- 37/M presented with acute onset paraparesis and paresthesia of both lower limbs that progressed over 1 week and has been static for 3 months
- He has a history of HIV/AIDS on ART and treated disseminated TB 1 year ago
- Exam shows flaccid paraparesis, sensory loss from L1, absent reflexes from C5-S1, and bladder involvement but no bowel involvement
- Differential includes infectious myeloradiculopathy (TB, HIV, CMV) or acute CIDP
- Investigations and management are planned including MRI, LP, immunological workup and immunosuppression
DENTIGEROUS CYST - a case presentation with reviewAshokKp4
This document presents two case studies of patients with dentigerous cysts in the maxilla. The first case involves a 26-year-old male with a swelling in the upper front tooth region. Examination and radiographs revealed a dentigerous cyst associated with teeth 11 and 21. The cyst was enucleated and pathology confirmed the diagnosis. The second case involves a 73-year-old male with pain and swelling in the upper front teeth region. Examination found a diffuse palatal swelling and missing tooth 11. Radiographs showed a dentigerous cyst associated with teeth 11 and 12. The patient underwent cyst enucleation and extraction of the impacted tooth. Both patients recovered well post-operatively without
This document describes the medical history and examination of a 28-year-old female patient presenting with proptosis of the right eye and decreased vision in that eye for 3 years. On examination, protrusion of the right eyeball was noted. Vision was reduced to finger counting in the right eye compared to 6/6 in the left eye. Neurological examination was normal except for slight restriction of abduction of the right eyeball. The patient was admitted for further investigation and management of a suspected orbital tumor.
Mr K, a 67-year-old man with hypertension, slipped disc, and rheumatoid arthritis, presented with blurry vision, redness, and floaters in his left eye. He was diagnosed with left eye panuveitis and treated with steroids, but was referred for further management. Examination found anterior vitreous cells, vitritis, and exudative retinal detachment in the left eye. Imaging showed dense vitritis and retinal detachment. He was admitted for investigations and treatment of suspected endogenous endophthalmitis from an unknown source. Vitreous biopsy was planned to identify the infectious organism.
This document presents the case of a 55-year-old male with a 3-year history of a neck swelling and 2-year history of bulging eyes. On examination, he has a multinodular goiter and signs of thyroid eye disease. Investigations show biochemical hyperthyroidism and imaging confirms a toxic nodular goiter with orbit involvement. He is diagnosed with toxic nodular goiter grade II and thyroid eye disease stage 2B, 3A, 4A, 5, and 6A based on the NOSPECS classification system. He is being treated with anti-thyroid medications and lubricating eye drops with plans for regular follow up.
Pediatric Neurology. A presentation on stroke in pediatric casessuser3fc2dd
A 7-year-old boy presented with 5 days of fever and 2 days of right-sided weakness. On examination, he had right arm and leg weakness with difficulty speaking but was otherwise normal. Investigations showed microcytic anemia, elevated white blood cells, and a turbid CSF with elevated proteins and white blood cells suggestive of pyogenic meningitis. CT scan showed mild brain edema. He was diagnosed with pyogenic meningitis.
1. Chronic kidney disease (CKD) and polycystic kidney disease (PKD) are genetic disorders that damage the kidneys and reduce their ability to filter waste from the blood.
2. PKD causes cysts to grow in the kidneys, changing their shape and size and potentially leading to kidney failure. It is a form of CKD.
3. There are five stages of CKD severity based on estimated glomerular filtration rate (eGFR) percentage, ranging from mild (Stage 1: 90% eGFR) to kidney failure (Stage 5: <15% eGFR). Physical symptoms worsen at later stages.
Dr. Maimuna Sayeed presented the case of an 11-month-old boy with breathing difficulties for 2 days, vomiting since 3 months of age, and dribbling of urine since birth. Examination found the boy to be dyspneic, pale, and hypertensive with ballotable kidneys and palpable bladder. Investigations supported chronic kidney disease stage 5 due to posterior urethral valve, with hydronephrosis, hydroureters, and vesicoureteral reflux seen on imaging. The boy was managed conservatively with antibiotics and peritoneal dialysis, showing improvement over follow-ups. Surgery consultation was planned to address the underlying valve abnormality.
Mr. X, a 65-year-old male farmer, presented with a swelling in the left side of his neck for 20 days. On examination, a large oval swelling was found occupying the upper left side of his neck. Investigation revealed the swelling to be neck secondaries of an unknown primary cancer. The differential diagnoses included tuberculous lymphadenitis and lymphoma. Treatment would involve radiotherapy or radical neck dissection followed by chemotherapy.
1. The document presents a case study of a 74-year-old male patient diagnosed with Parkinson's disease. It includes details on the patient's history, examination findings, and management.
2. The objectives of the case study were to share knowledge with supervisors, get feedback, and improve presentation skills. Parkinson's disease causes abnormal movements and difficulties with walking.
3. Examination revealed symptoms of Parkinson's disease including a shuffling gait, masked facial expressions, tremors, and rigidity.
This case presentation describes a 30-year-old male who presented with gradual weakness in both lower limbs over 3 days. Initial treatment with analgesics and IV fluids provided no improvement. Nerve conduction studies revealed sensorimotor nerve affection in the lower limbs suggestive of Guillain-Barré syndrome. However, after admission the patient was found to be hypokalemic, which when corrected with IV potassium infusion resulted in rapid improvement of his weakness. Differential diagnoses discussed include various causes of secondary periodic paralysis and other entities that could cause acute generalized weakness.
A case of 42 year old male presented with fever, weight loss and axillary swelling and shortness of breath. so what will be diagnosis and further management?
This document summarizes the case of a 21-year-old female patient presenting with a 3-year history of skin rashes, 6-month history of oral ulcers, and 7-day history of fever. On examination, she appeared ill and emaciated with maculopapular rashes, alopecia, and oral ulcers. Laboratory tests showed elevated inflammatory markers, protein in the urine, and positive antinuclear antibody and anti-dsDNA antibodies. A skin biopsy revealed a lupus band. Based on the clinical presentation and test results, she was diagnosed with systemic lupus erythematosus. She was prescribed various medications including hydroxychloroquine, methotrexate, and
- 8 year old boy presented with progressive darkening of skin, recurrent fever, weakness, and weight loss over 3 years.
- Examination found hypotension, postural drop, and hyperpigmentation. Tests showed low cortisol and high ACTH.
- Provisional diagnosis of Addison's disease was made, which was confirmed by further investigations.
- Final diagnosis was Addison's disease due to tuberculosis, and treatment with antibiotics, antitubercular drugs, and hydrocortisone was started.
Lecture 6 -- Memory 2015.pptlearning occurs when a stimulus (unconditioned st...AyushGadhvi1
learning occurs when a stimulus (unconditioned stimulus) eliciting a response (unconditioned response) • is paired with another stimulus (conditioned stimulus)
More Related Content
Similar to Ophthalmology-cyst A case presentation.pptx
A 58-year-old male presented with a painless, gradually progressive swelling below his right ear for one year. On examination, he was found to have a solitary, firm-to-hard, bilobed swelling measuring 8x3cm in the right parotid region. All other physical findings were normal. The probable diagnosis is a swelling of the right parotid gland.
A 14-year-old boy presented with difficulty breathing, facial swelling, swelling of both feet, and chest pain for two days. He had a history of a similar episode 8 months prior where he was diagnosed with a heart condition. On examination, he had an irregularly irregular pulse, low blood pressure, visible apex beat, and grade V pansystolic murmurs in the mitral, tricuspid, and pulmonary areas, suggestive of chronic rheumatic heart disease with mitral regurgitation and left ventricular hypertrophy.
The 85-year-old male patient presented with progressive forgetfulness, weight loss, and depressed mood over the past year since his wife's death. His daughter observed a decline in his ability to recall recent events, directions, and names. Alzheimer's disease is the primary consideration given his age and symptoms consistent with typical memory loss and cognitive decline seen in Alzheimer's. Differential diagnoses considered include delirium, depression, and hypothyroidism but were deemed less likely based on aspects of his history and presentation that did not fully match these conditions.
The 85-year-old male patient presented with progressive forgetfulness, weight loss, and depressed mood over the past year since his wife's death. His daughter observed deterioration in his memory, concentration, and ability to carry on conversations. Alzheimer's disease is the primary consideration given his age and symptom progression. Differential diagnoses considered include delirium, depression, and hypothyroidism but were deemed less likely based on aspects of his clinical presentation and history.
1. A 21-year-old female presented with progressive weakness on the right side of her body over 1.5 years, along with fever, headache, diplopia, and two seizures.
2. Neurological examination revealed spastic right hemiparesis, internuclear ophthalmoplegia, nystagmus, and ataxic gait.
3. MRI brain showed multiple enhancing lesions in the midbrain, left periventricular area, and left basal ganglia, suggestive of tuberculomas. She was diagnosed with multiple tuberculomas and treated with anti-tuberculosis therapy and steroids.
- 37/M presented with acute onset paraparesis and paresthesia of both lower limbs that progressed over 1 week and has been static for 3 months
- He has a history of HIV/AIDS on ART and treated disseminated TB 1 year ago
- Exam shows flaccid paraparesis, sensory loss from L1, absent reflexes from C5-S1, and bladder involvement but no bowel involvement
- Differential includes infectious myeloradiculopathy (TB, HIV, CMV) or acute CIDP
- Investigations and management are planned including MRI, LP, immunological workup and immunosuppression
DENTIGEROUS CYST - a case presentation with reviewAshokKp4
This document presents two case studies of patients with dentigerous cysts in the maxilla. The first case involves a 26-year-old male with a swelling in the upper front tooth region. Examination and radiographs revealed a dentigerous cyst associated with teeth 11 and 21. The cyst was enucleated and pathology confirmed the diagnosis. The second case involves a 73-year-old male with pain and swelling in the upper front teeth region. Examination found a diffuse palatal swelling and missing tooth 11. Radiographs showed a dentigerous cyst associated with teeth 11 and 12. The patient underwent cyst enucleation and extraction of the impacted tooth. Both patients recovered well post-operatively without
This document describes the medical history and examination of a 28-year-old female patient presenting with proptosis of the right eye and decreased vision in that eye for 3 years. On examination, protrusion of the right eyeball was noted. Vision was reduced to finger counting in the right eye compared to 6/6 in the left eye. Neurological examination was normal except for slight restriction of abduction of the right eyeball. The patient was admitted for further investigation and management of a suspected orbital tumor.
Mr K, a 67-year-old man with hypertension, slipped disc, and rheumatoid arthritis, presented with blurry vision, redness, and floaters in his left eye. He was diagnosed with left eye panuveitis and treated with steroids, but was referred for further management. Examination found anterior vitreous cells, vitritis, and exudative retinal detachment in the left eye. Imaging showed dense vitritis and retinal detachment. He was admitted for investigations and treatment of suspected endogenous endophthalmitis from an unknown source. Vitreous biopsy was planned to identify the infectious organism.
This document presents the case of a 55-year-old male with a 3-year history of a neck swelling and 2-year history of bulging eyes. On examination, he has a multinodular goiter and signs of thyroid eye disease. Investigations show biochemical hyperthyroidism and imaging confirms a toxic nodular goiter with orbit involvement. He is diagnosed with toxic nodular goiter grade II and thyroid eye disease stage 2B, 3A, 4A, 5, and 6A based on the NOSPECS classification system. He is being treated with anti-thyroid medications and lubricating eye drops with plans for regular follow up.
Pediatric Neurology. A presentation on stroke in pediatric casessuser3fc2dd
A 7-year-old boy presented with 5 days of fever and 2 days of right-sided weakness. On examination, he had right arm and leg weakness with difficulty speaking but was otherwise normal. Investigations showed microcytic anemia, elevated white blood cells, and a turbid CSF with elevated proteins and white blood cells suggestive of pyogenic meningitis. CT scan showed mild brain edema. He was diagnosed with pyogenic meningitis.
1. Chronic kidney disease (CKD) and polycystic kidney disease (PKD) are genetic disorders that damage the kidneys and reduce their ability to filter waste from the blood.
2. PKD causes cysts to grow in the kidneys, changing their shape and size and potentially leading to kidney failure. It is a form of CKD.
3. There are five stages of CKD severity based on estimated glomerular filtration rate (eGFR) percentage, ranging from mild (Stage 1: 90% eGFR) to kidney failure (Stage 5: <15% eGFR). Physical symptoms worsen at later stages.
Dr. Maimuna Sayeed presented the case of an 11-month-old boy with breathing difficulties for 2 days, vomiting since 3 months of age, and dribbling of urine since birth. Examination found the boy to be dyspneic, pale, and hypertensive with ballotable kidneys and palpable bladder. Investigations supported chronic kidney disease stage 5 due to posterior urethral valve, with hydronephrosis, hydroureters, and vesicoureteral reflux seen on imaging. The boy was managed conservatively with antibiotics and peritoneal dialysis, showing improvement over follow-ups. Surgery consultation was planned to address the underlying valve abnormality.
Mr. X, a 65-year-old male farmer, presented with a swelling in the left side of his neck for 20 days. On examination, a large oval swelling was found occupying the upper left side of his neck. Investigation revealed the swelling to be neck secondaries of an unknown primary cancer. The differential diagnoses included tuberculous lymphadenitis and lymphoma. Treatment would involve radiotherapy or radical neck dissection followed by chemotherapy.
1. The document presents a case study of a 74-year-old male patient diagnosed with Parkinson's disease. It includes details on the patient's history, examination findings, and management.
2. The objectives of the case study were to share knowledge with supervisors, get feedback, and improve presentation skills. Parkinson's disease causes abnormal movements and difficulties with walking.
3. Examination revealed symptoms of Parkinson's disease including a shuffling gait, masked facial expressions, tremors, and rigidity.
This case presentation describes a 30-year-old male who presented with gradual weakness in both lower limbs over 3 days. Initial treatment with analgesics and IV fluids provided no improvement. Nerve conduction studies revealed sensorimotor nerve affection in the lower limbs suggestive of Guillain-Barré syndrome. However, after admission the patient was found to be hypokalemic, which when corrected with IV potassium infusion resulted in rapid improvement of his weakness. Differential diagnoses discussed include various causes of secondary periodic paralysis and other entities that could cause acute generalized weakness.
A case of 42 year old male presented with fever, weight loss and axillary swelling and shortness of breath. so what will be diagnosis and further management?
This document summarizes the case of a 21-year-old female patient presenting with a 3-year history of skin rashes, 6-month history of oral ulcers, and 7-day history of fever. On examination, she appeared ill and emaciated with maculopapular rashes, alopecia, and oral ulcers. Laboratory tests showed elevated inflammatory markers, protein in the urine, and positive antinuclear antibody and anti-dsDNA antibodies. A skin biopsy revealed a lupus band. Based on the clinical presentation and test results, she was diagnosed with systemic lupus erythematosus. She was prescribed various medications including hydroxychloroquine, methotrexate, and
- 8 year old boy presented with progressive darkening of skin, recurrent fever, weakness, and weight loss over 3 years.
- Examination found hypotension, postural drop, and hyperpigmentation. Tests showed low cortisol and high ACTH.
- Provisional diagnosis of Addison's disease was made, which was confirmed by further investigations.
- Final diagnosis was Addison's disease due to tuberculosis, and treatment with antibiotics, antitubercular drugs, and hydrocortisone was started.
Similar to Ophthalmology-cyst A case presentation.pptx (20)
Lecture 6 -- Memory 2015.pptlearning occurs when a stimulus (unconditioned st...AyushGadhvi1
learning occurs when a stimulus (unconditioned stimulus) eliciting a response (unconditioned response) • is paired with another stimulus (conditioned stimulus)
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
Kosmoderma Academy, a leading institution in the field of dermatology and aesthetics, offers comprehensive courses in cosmetology and trichology. Our specialized courses on PRP (Hair), DR+Growth Factor, GFC, and Qr678 are designed to equip practitioners with advanced skills and knowledge to excel in hair restoration and growth treatments.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
DECLARATION OF HELSINKI - History and principlesanaghabharat01
This SlideShare presentation provides a comprehensive overview of the Declaration of Helsinki, a foundational document outlining ethical guidelines for conducting medical research involving human subjects.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
5. HISTORY OF PRESENT ILLNESS
2 years
PTC
• painless mass on the left lower eyelid and nasal area approximately 1 cm in diameter with lacrimation
• no other associated symptoms noted
• no consult done, no medications taken
Interim
• gradual growth noted seldom accompanied with tolerable pain and lacrimation
• due to pandemic, not able to seek consult
9 months
PTC
• increasing size of the mass still noted
• redness and pus on the medial left lower eyelid, prompted consult in this institution
• advised to undergo surgery
• antibiotic eye ointment was prescribed but lost to follow up
1 month
PTC
• persistent growth of the mass still noted
• sought consult in this institution and MRI was requested with this result: inferior orbital cyst, primary
consideration is nasolacrimal duct mucocele, another consideration, albeit less considered, is a
dacrocystocele. Small right maxillary retention cyst.
• advised for surgery
6. PAST MEDICAL HISTORY
• Complete immunization
• (-) childhood illness
• (-) history of surgical operation
• (-) known allergy to food and drugs
• (-) previous traumatic injuries
7. FAMILY HISTORY
• an only child
• (+) history of diabetes mellitus and hypertension
• no other heredofamilial diseases such as
neoplasms and asthma
8. Developmental/Behavioral History
● Home: His parents separated 8 years ago and both his parents have
partners. Prior to the pandemic, he lives with his mother and her
common-law partner in Burauen, Leyte. He currently lives with his
father and his common law partner and will go back to stay with her
mother when face-to-face classes start. He claimed to have no
complaints with the situation.
● Education: He is currently Grade 10 student at Burauen
Comprehensive High School. The patient used to be fond of engaging
in extra-curricular activities during the face-to-face classes.
● Eating: He is not a picky eater.
9. Developmental/Behavioral History
● Activities: He used to hang out with his friends and cousins during his
free time but due to pandemic, it was limited. The patient is active on
social media.
● Drugs: His father is a smoker and occasional alcoholic beverage
drinker. The patient does not drink alcoholic beverages, smoke, and
use illicit drugs.
● Sexuality: He is more fond being friends with girls and currently is not
in a romantic relationship.
● Suicide/depression: The mass does not concern him at all but hoping
that it will be removed before the face-to-face classes start. He has no
history of depression and no suicidal thoughts and ideations.
11. Physical Examination
General Survey:
● The patient is an ectomorphic adolescent. He was examined awake,
conscious, coherent, oriented to time, place and person, fairly-groomed and
not in cardiorespiratory distress.
Vital Signs Actual Ideal Interpretation
Temperature 36.5 0C, axillary 36.5 – 37.5°C Afebrile
Pulse rate 89 bpm 55 – 85 bpm Normal
Respiratory rate 16 cpm 12 – 18 cpm Normal
Blood pressure 110/80 mmHg @ left arm 110-135/65-85 mmHg Normotensive
12. Physical Exam
Head:
Face - symmetrical facial expression noted,
(+) firm, movable painless mass on the medial
left lower eyelid and nasal area, with smooth
regular border, approx. 3 x 2 cm
Eye:
VA: OU - 20/20
left medial canthus slightly displaced
superiorly
Eyebrows: Symmetrical, equal movement
upon raising of eyebrows, fine, and black.
Eyelids: (+) redness on medial left lower
eyelid, no inward or outward turning of
eyelids, no lagging and with adequate closure
Eyelashes: Black in color and are evenly
distributed with outward curving along the lid
margins
Conjunctiva: (+) redness medial bulbar
conjunctiva, OS
Sclera: anicteric
Cornea: no ulcerations, no scars
Iris and Pupil: Iris is round, flat, evenly brown
colored. Pupils are symmetrical, 3mm in
diameter and reactive to direct light and
consensual light reflex
EOM: Full EOM movement
ROR: (+), OU
Tonometer (manual): firm, OU
(-) LAI
13. Salient Features
Demograph
ics
HPI Other History
Findings
ROS/PE
15 years old
Male
CC: inferior orbital mass
• 2-year history of gradually
growing mass on the left
lower eyelid and nasal area
• seldom accompanied with
tolerable pain and
lacrimation
• History of redness and pus
on the medial left lower
eyelid
Pertinent negative:
- No fever
- No referred pain
- No palpable lymph nodes
• No history of any
childhood illness
• No family history
of neoplasms
• (+) firm, movable
painless mass on the left
lower eyelid and nasal
area, with regular
borders, approx. 3 x 2
cm
• left medial canthus
slightly displaced
superiorly
• (+) redness on medial
left lower eyelid
• (+) redness medial
bulbar conjunctiva
• (-) Jones Dye Test
15. Rule in Rule out
2-year history of gradually growing
mass on the left lower eyelid and
nasal area
inferior orbital mass
(+) firm, movable painless mass
on the left lower eyelid and nasal
area, with regular borders, approx.
3 x 2 cm
left medial canthus slightly
displaced superiorly
X 15 years old
X (-) LAI
Dermoid Cyst
https://www.ncbi.nlm.nih.gov/books/NBK560573/
16. Rule in Rule out
inferior orbital mass
2-year history of gradually growing mass on the
left lower eyelid and nasal area
seldom accompanied with tolerable pain
History of redness and pus on the left lower
eyelid
(+) firm, movable painless mass on the left
lower eyelid and nasal area, with regular
borders, approx. 3 x 2 cm
left medial canthus slightly displaced superiorly
(-) LAI
X Male (more common in
female)
X 15 years old (first year of life)
- Cannot completely rule out
Nasolacrimal Duct Mucocele
https://www.ncbi.nlm.nih.gov/books/NBK560573/
17. Rule in Rule out
inferior orbital mass
2-year history of gradually growing mass on the
left lower eyelid and nasal area
seldom accompanied with tolerable pain
History of redness and pus on the left lower
eyelid
(+) firm, movable painless mass on the left
lower eyelid and nasal area, with regular
borders, approx. 3 x 2 cm
left medial canthus slightly displaced superiorly
(-) LAI
X 15 years old (first 5 years of
life)
- Cannot completely rule out
Dacryocystocele
https://www.ncbi.nlm.nih.gov/books/NBK560573/
19. Dye disappearance test (DDT) and lacrimal irrigation
● simplified approach
● usually followed by Jones I test then
Jones II test
Contrast dacryocystography and
dacryoscintigraphy
● alternative methods of evaluation
20. CT Scan or MRI
● useful in the evaluation of craniofacial injury, congenital craniofacial
deformities, or suspected neoplasia
● MRI done with result (03/03/2022): inferior orbital cyst, primary
consideration is nasolacrimal duct mucocele, another consideration,
albeit less considered, is a dacryocystocele. Small right maxillary
retention cyst.
The presence of dye in the inferior meatus indicates a positive result of Jones I; the dye presumably flowed from the tear lake to the inferior meatus via a patent lacrimal system. A negative test suggests an obstructed lacrimal system.
A dermoid cyst is a benign cutaneous developmental anomaly that arises from the entrapment of ectodermal elements along the lines of embryonic closure. Dermoid cysts usually tend to grow slowly. A lower lid dermoid cyst may be evident as a painless, gradually enlarging swelling of the lower lid.[10] Dermoid cysts in the medial canthal area may present as masses adherent to lacrimal canaliculi. They are usually asymptomatic, non-pulsatile, and non-compressible. However, Dermoid cysts are usually congenital, with about 70% of cases discovered in children five years old or younger.
Nasolacrimal duct mucoceles (NLDMs) are encountered almost exclusively in the pediatric population. Nasolacrimal duct mucocele typically presents as a bulging in the lower medial canthus of the eye, associated with epiphora.
Dacryocele is also known as a dacryocystocele, amniotocele, amniocele, or mucocele. It is formed when a distal blockage (usually membranous) of the lacrimal sac causes distention of the sac, which also kinks and closes off the entrance to the common canaliculus.
the clinical evaluation of the lacrimal drainage system historically comprised a dye disappearance test (DDT) followed by the Jones I test (swabbing the inferior meatus to see if dye passes through physiologically) and the Jones II test (irrigating with saline and assessing the passage of fluid and presence or absence of dye). Although some clinicians continue to rely on formal Jones testing, most use a simplified approach involving only the DDT and lacrimal irrigation.
The DDT is useful for assessing the presence or absence of adequate lacrimal outflow, especially in unilateral cases.
Lacrimal drainage system irrigation is most frequently performed immediately after the DDT to determine the level of lacrimal drainage system occlusion
A, Complete canalicular obstruction. The cannula is advanced with difficulty, and irrigation fluid refluxes from the same canaliculus.
B, Complete common canalicular obstruction. A “soft stop” is encountered at the level of the common canaliculus, and irrigated fluid refluxes through the opposite punctum and sometimes partially from the same canaliculus as well.
C, Complete nasolacrimal duct obstruction (NLDO). The cannula is easily advanced to the medial wall of the lacrimal sac; then a “hard stop” is felt, and irrigation fluid refluxes through the opposite punctum. Often, the refluxed fluid contains mucus and/or pus. With a tight valve of Rosenmüller, lacrimal sac distention without reflux of irrigation fluid may occur.
D, Partial NLDO. The cannula is easily placed, and irrigation fluid passes into the nose as well as refluxing through the opposite punctum.
E, Patent lacrimal drainage system. The cannula is placed with ease, and most of the irrigation fluid passes into the nose.
CT and MRI are CT is superior for the evaluation of suspected bony abnormalities, such as fractures. MRI is superior for the evaluation of suspected soft- tissue disease, such as malignancy. Either CT or MRI may be helpful in evaluating concomitant sinus or nasal disease that may contribute to excess tearing.
Lacrimal pump mechanism. A, In the relaxed state, the puncta lie in the tear lake, and the lacrimal sac is filled with tears. B, With eyelid closure, contraction of the pretarsal orbicularis closes the puncta and canaliculi. The preseptal orbicularis fibers, which insert onto the sac, also compress the sac, creating positive pressure that propels tears through the duct. C, With eyelid opening, the orbicularis relaxes, and the puncta and sac open, creating negative pressure that draws tears into the canaliculi and lacrimal sac. As the eyelids close, the cycle repeats.
A DCR is the treatment of choice for most patients with acquired NLDO. Surgical indications include recurrent dacryocystitis, chronic mucoid reflux, painful distention of the lacrimal sac, and bothersome epiphora.
Recent data indicate similar success rates for the 2 approaches. The advantages of an internal (endonasal) DCR include lack of a visible scar, a shorter recovery period, and less discomfort. An external DCR may allow better exposure for management of canalicular stenosis, unexpected neoplasm, or dacryoliths.
Intubation and stenting Partial stenosis of the NLD with symptomatic epiphora may respond to surgical intubation of the entire lacrimal drainage system. This procedure should be performed only if the tubes can be passed easily. In cases of complete NLDO, intubation alone is not effective, and a DCR should be considered.
Endoscopic lacrimal duct recanalization The use of a microendoscope allows for exploration and direct visualization of NLDOs, as well as focal excision and reconstruction of the obstruction, and has had success rates as high as those for DCR. The use of this technology is not widespread, and further study will help define its role in the treatment of NLDO.