This document outlines the principles, design, organization, and responsibilities within an operating room (OR) setting, highlighting the significance of maintaining aseptic techniques and efficient layout to ensure patient safety. It defines different areas of the OR, such as unrestricted, semi-restricted, and restricted zones, and describes the roles of both sterile and unsterile teams in surgical procedures. Key considerations for effective OR management include communication among team members, economical use of resources, and qualities necessary for OR personnel.