This study compared the effectiveness of Mode Deactivation Therapy (MDT) to Treatment As Usual (TAU) for adolescent residential patients with conduct and personality disorders. Assessments before and after treatment found MDT significantly reduced aggressive behavior, therapeutic holds, depression, and suicidal ideation more than TAU. MDT led to a 70.7% decrease in holds and 66.8% reduction in aggression compared to 24.7% and 27.9% for TAU. The results suggest MDT is more effective than TAU for treating conduct disorders in adolescents.