4. PLACENTA PREVIA
• 1 in 200-250deliveries.
• Cardinal symptom of placenta previa is painless vaginal bleeding.
• first episode usually stops spontaneously.
• Bleeding typically manifests at approximately 32week of gestation, when the lower
uterine segment begins to form.
• When this diagnosis is suspected, the position of the placenta needs to be
confirmed via ultrasonography or radioisotope scan.
• Placenta previa occurs when implantation of the placenta is low in the uterus;
• it is either overlying or encroaching on the cervical os.
• Placenta previa is present in approximately 0.6% of all pregnancies.
• It categorized as :
– complete if the placenta completely covers the os,
– partial if there is some encroachment on the os by the placenta,
– marginal if the placenta is not covering but is close to the internal os
5. Conti……
• ETIOLOGY:
• Unknown
• Previous placenta previa
• Advanced maternal age
• The condition is more common in multiparous women, and it is especially common
in women who have had a previous cesarean section.
• Typically, in contrast with placental abruption,
• placenta previa is characterized by painless vaginal bleeding in the third trimester.
• Management :
• Bleeding may stop spontaneously, in which case conservative management is
recommended.
• Urgent/emergent cesarean delivery for active or persistent bleeding or fetal
distress.
• Except for a patient with a marginal previa who might elect. vaginal delivery, other
patient will be delivered by cesarean section.
6. Conti..
• Anesthetic Management
• Anesthetic management is dependent on the obstetric plan and the
condition of the parturient.
• Preoperative
• Mild to moderate blood loss is well tolerated by the patient .
• Adequate volume resuscitation is thus paramount to the patient's care.
• All patients should be typed and cross-matched to ensure continuous availability of
packed red blood cells and, if needed, blood products.
• Intraoperative
• Parturients with a total or partial previa will deliver by cesarean section.
• Anesthetic management will depend on maternal and fetal status and the urgency
of the surgery.
7. Conti...
• If patient has not had recent bleeding and is scheduled electively, regional
anesthesia is preferred.
• Large-bore intravenous access should be established as the patient is at greater
risk of intraoperative bleeding.
• Cross-matched blood should be immediately available.
• If hemorrhage necessitates emergency delivery, general anesthesia is the
anesthetic technique of choice.
• Ketamine and etomidate are the preferred induction agents in the hypovolemic
patient. Maintenance of anesthesia will be determined by the hemodynamic
status of the mother.
8. Placental abruption
• Placental abruption, a partial or complete separation of the placenta before
delivery of the fetus.
• occur in 1.3% to 1.6% of pregnancies.
• Preexisting conditions such as
– chronic hypertension,
– pregnancy-induced hypertension,
– preeclampsia,
– maternal cocaine use,
– excessive alcohol intake,
– smoking,
– previous history of abruption
Placental abruption may be manifested as vaginal bleeding and uterine
tenderness
9.
10. conti…
• Vaginal bleeding-Classical presentation
• May not always be obvious
• 3000 ml or more blood can be sequestered behind placenta in concealed bleeding
• Uterus can’t selectively constrict abrupted area
• Decreased placental area-fetal asphyxia
• 1 in 750 deliveries-fetal death
• Severe neurological damage in some surviving infants
• Upto 90% abruptions-mild to moderate
• Problems: Hemorrhage, Consumptive coagulopathy, Fetal hypoxia, Prematurity
• Low fibrinogen/ Factor V, Factor VII and platelets and increased fibrin split products
Treatment
• Definitive treatment of abruptio placentae is delivery of the fetus and placenta.
Delivery may be vaginal if the abruption is not jeopardizing maternal or fetal well-
being. Otherwise, delivery is by cesarean section.
11. Conti....
Anesthetic Management
• If maternal hypotension is absent, clotting studies are acceptable, and there is no
evidence of fetal distress due to uteroplacental insufficiency,
• epidural analgesia is useful for providing analgesia for labor and vaginal delivery.
• When magnitude of placental separation and resulting hemorrhage are severe,
emergency cesarean section is necessary.
• most often, general anesthesia is used, as regional anesthesia in a
hemodynamically unstable.
• Anesthetic management is similar to that employed with placenta previa. Blood
and blood products should be readily available due to the risk of bleeding and DIC.
• It is not uncommon for blood to dissect between layers of the myometrium after
premature separation of the placenta.
• As a result, the uterus is unable to contract adequately after delivery, and
postpartum hemorrhage occurs.
• Uncontrolled hemorrhage may require an emergency hysterectomy.
• Bleeding may be exaggerated by coagulopathy, in which case infusion of fresh
frozen plasma and platelets may be indicated to replace deficient clotting factors.
• Clotting parameters usually revert to normal within a few hours after delivery of
the neonate.
12. Placenta Accreta
• Definition: abnormal development and implantation of the placenta. Or
abnormally adherent to the myometrium.
• Placenta accreta is an adherent placenta that has not invaded the myometrium.
• placenta increta, the placenta has invaded the myometrium
• placenta percreta is invasion through the
serosa.
• Incidence: 1 in 2000 deliveries but higher in
– placenta previa
– prior C-section
13. Conti..
Signs and Symptoms
• Retained placenta and postpartum hemorrhage occur in patients with placenta
accreta.
• Treatment
• The majority of cases require cesarean hysterectomy.
Anesthetic Management
• Preoperative
• Significant hemorrhage should be anticipated and thus at least two large-bore
intravenous catheters placed. arterial catheter should be considered.
• Packed red blood cells should be immediately available and blood products readily
available.
• use of a cell saver should be considered after delivery.
14. Conti..
• preoperative interventional radiography consultation should be obtained as
arterial embolization may reduce intraoperative blood loss.
• Intraoperative
• Intraoperative management of a patient at risk of hemorrhage and/or cesarean
hysterectomy is controversial.
• Many believe all patients should received general anesthesia (as discussed for
patients with a placenta previa).
• Others argue that if needed, a cesarean hysterectomy can be performed under
epidural anesthesia.
15. UTERINE RUPTURE
• Prepartum, intrapartum or postpartum
• ETIOLOGY:
– Prior cesarean delivery especially classical cesarean scar
– Rupture of myomectomy scar
– Precipitous labor
– Prolonged labor with cephalopelvic disproportion
– Excessive oxytocin stimulation
– Abdominal trauma
– Grand multiparity
– Iatrogenic
– Direct uterine trauma-forceps or curettage
16. Conti..
Signs and Symptoms
• Uterine rupture may present with severe abdominal pain, often referred to the
shoulder due to subdiaphragmatic irritation by intra-abdominal blood, maternal
hypotension, and disappearance of fetal heart tones.
Diagnosis
• An ultrasound examination is useful in making the diagnosis of uterine rupture.
Visual examination of the uterus at cesarean delivery will detect rupture or
dehiscence. Manual examination with vaginal delivery will detect dehiscence as
well.
Treatment
• Uterine rupture with maternal and/or fetal distress mandates immediate
laparotomy, delivery, and surgical repair or hysterectomy.
Prognosis
• Maternal mortality is rare. Fetal mortality is approximately 35%.
Anesthetic Management
• Anesthetic management is similar to that for the unstable patient with placenta
previa
17. Uterine atony
• Uterine atony is the most common cause of postpartum hemorrhage, and it is
caused by ineffective uterine muscle contraction in the postpartum period.
• Risk factors include prolonged labor, an overdistended uterus (macrosomia or
multiple births), infection, grand multiparity, and administration of drugs that relax
the uterus (halogenated anesthetics, β-sympathomimetic agonists, and magnesium
sulfate).
• Surgical compression suturing (“B-Lynch suture”) is an important technique for
treating postpartum hemorrhage associated with uterine atony and may avoid the
need for cesarean hysterectomy.
18. Uterine Atony
Medicatio
n
Class Administratio
n
Dosing Side effect Comments
Oxytocin Neurohypoph
yseal
hormone
Infusion Up to 40
IU/l
Hypotension
with rapid
infusion
Initial
therapy
Methylergo
novine
Ergot alkaloid Intramuscular 0.4 mg IM
repeat
once
Hypertension Sustained
increase in
uterine tone
Carboprost Prostaglandin Intramuscular
intramyometri
al
0.25mg IM
repeat up
to 1.0mg
total
Systemic and
pulmonary
hypertension,
bronchospas
m
Never
administer
intravenousl
y
19. RETAINED PLACENTA
• The placenta is said to be retained if it has not been delivered within 30 - 60
minutes of the birth.
• occurs in approximately 1% of vaginal deliveries.
• The following are risk factors:
– Previous retained placenta
– Previous injury to uterus
– Pre-term delivery
– Induced labour
– Multiparity
• Management
• Manual removal of the placenta(MRP) is the standard treatment and is usually
carried out under anaesthesia (or more rarely, under sedation and analgesia).
20. Comparison of general anaesthesia, regional anaesthesia and sedation
Technique Advantages Disadvantages
GA Dose-dependent
uterine
relaxation by
volatile agent.
Risks of general anaesthesia e.g. airway
compromise, aspiration, anaphylaxis.
Spinal Rapid
establishment of
profound
analgesia.
Avoids risks of
GA.
Potential for sudden hypotension if
extent of haemorrhage not recognised.
Epidural Good if already
in situ
Takes time to establish de novo
Sedation Quick and easy Poor uterine relaxation
Unprotected airway: risk of aspiration if
overdose
21. Conti..
General anaesthesia and sedation
• A rapid sequence induction should be performed following adequate pre-
oxygenation.
• If woman is in shock, etomidate or ketamine are preferable to thiopental or
propofol as induction agents.
• Equipotent doses of all the volatile agents depress uterine contractility .
• Electrocardiogram, blood pressure and end-tidal CO2/vapour tension should be
monitored .
• Fentanyl, midazolam and ketamine can all be given by titrated i.v. increments.
Regional anaesthesia
• Spinal anaesthesia avoids the risks associated with general anaesthesia. 2.0 - 2.5ml
of hyperbaric bupivacaine 0.5% should ensure cold sensation blockade to T6 and
maternal intra-operative comfort. Hypotension secondary to regional anaesthesia
is likely to be related to maternal blood loss rather than block height.
• A low-dose spinal anaesthetic regimen comprising 1.5ml 0.25% plain bupivacaine
and fentanyl 25micrograms has been shown to provide satisfactory operative
conditions. Motor function preserved, and maternal satisfaction is high.
22. Uterine Inversion
• Uterine inversion is a rare cause of postpartum hemorrhage .
• uterine fundus inverts through the cervix into the vagina.
• Hypotension usually results before significant blood loss has occurred.
Treatment :-
• fluid therapy for the mother and restoration of the uterus to its normal position.
• Uterine relaxation may be necessary to replace the uterus; β-sympathomimetic
agents, magnesium, and nitroglycerin .
• choice of agent may be dependent on the mother's hemodynamic stability.
• For example, in the case of profound maternal hypotension, magnesium sulfate
may be a better choice than nitroglycerin.
• Should initial efforts to replace the uterus prove unsuccessful, rapid-sequence
induction with cricoid pressure and endotracheal intubation should be undertaken.
The use of volatile agents will also cause uterine relaxation, thereby assisting the
obstetrician in replacing the uterus.
23. BIRTH TRAUMA/LACERATIONS
• Lesions range from laceration to retroperitoneal hematoma requiring laparotomy
• Can result from difficult forceps delivery/
• Precipitous vaginal delivery/
• Malpresentation of fetal head (OP)/
• Laceration of pudendal vessels/
• Clinical presentation of postpartum bleeding with contracted uterus
• Saddle (SAB)/Epidural/or GA given to repair of trauma.
24. Hypovolemic Shock
• Circulatory failure leading to inadequate perfusion and delivery of oxygen to vital
organs.
• Blood Pressure is often used as an indirect estimator of tissue perfusion.
• Oxygen delivery is an interaction of Cardiac Output, Blood Volume, Systemic
Vascular Resistance.
• Causes-
– Trauma
– Blood Loss
– Occult fluid loss (GI)
– Burns
– Pancreatitis
– Sepsis (distributive, relative hypovolemia)
25. Class I Class II Class III Class IV
Blood loss (ml) ≤750 750-1500 1500-2000 >2000
% blood loss ≤15 15-30 30-40 >40
Heart rate (bpm) <100 >100 >120 >140
SBP N N ↓ ↓
Pulse pressure N or ↑ ↓ ↓ ↓
Cap Refill < 3 sec > 3 sec >3 sec or absent absent
Resp rate/ min 14-20 20-30 30-40 <35
Urine output
(ml/hr)
>30 20-30 5-15 Negligible
Mental status Slightly
anxious
Mildly anxious Anxious and
confused
Confused and
lethargic
CLASSIFICATION OF HEMORRHAGIC SHOCK
26. Pathophysiology Clinical Manifestation
Mild(<20% of
blood volume
lost)
Decreased peripheral
perfusion only of organ able
to withstand prolonged
ischemia (skin, fat, muscle,
and bone)
Pt complaint of feeling cold
Postural hypotension and
tachycardia
Cool, pale, and moist skin
Concentrated urine
Moderate(20-
40% of blood
volume lost)
Decreased central perfusion
of organs able to tolerate
only brief ischemia(kidney,
liver)
Metabolic acidosis present
Thirst
Supine hypotension and
tachycardia(variable)
Oligouria and anuria
Severe(>40%
of blood
volume lost)
Decreased perfusion of heart
and brain
Severe metabolic acidosis
Respiratory acidosis possibly
present
Agitation, confusion, or
obtundation
Supine hypotension and
tachycardia invariabaly present
Rapid, deep respiration
27. Fluid Resuscitation of Shock
Crystalloid Solutions
• Normal Saline
• Lactated Ringers Solution
• DNS
• Require 3:1 replacement of volume loss
• e.g. estimate 1 L blood loss, require 3 L of crystalloid to replace volume.
• Intravenous fluids are recommended in most types of shock (1-2 liter normal saline
bolus over 10 minutes or 20ml/kg in a child) If the person remains in shock after
initial resuscitation packed red blood cell should be administered to keep the
hemoglobin greater than 10 gms/dl.
• Hemorrhagic shock the current evidence supports limiting the use of fluids for
penetrating thorax and abdominal injuries allowing mild hypotension to persist
(known as permissive hypotension).
• Targets include a mean arterial pressure of 60 mmHg, a systolic blood pressure of
70-90 mmHg. or until their adequate peripheral pulses.
28. Conti…
Colloid Solutions
• Pentastarch
• Albumin 5%
• Red Blood Cells
• Fresh Frozen Plasma
• Replacement of lost volume in 1:1 ratio
Oxygen Carrying Capacity
• Only RBC contribute to oxygen carrying capacity (hemoglobin)
• Replacement with all other solutions will
o support volume
o Improve end organ perfusion
o Will NOT provide additional oxygen carrying capacity.
29. RBC Transfusion
BC Red Cell Transfusion Guidelines recommend transfusion only to keep Hgb >7
g/dL unless
– Comorbid disease necessitating higher transfusion trigger (CAD, pulmonary
disease, sepsis)
– Hemodynamic instability despite adequate fluid resuscitation.
– PRBC’s at 5-10 cc/kg.
Estimating the resuscitating volume
Normal blood volume(BV)= 66ml/kg in male and 60ml/kg in female
Volume deficit(VD)= BV ˣ % of loss blood volume
Determine resuscitating volume(RV)= VD ˣ1.5(colloids)
=VD ˣ 4(crystalloid)
30. Definition of massive transfusion
• The replacement of patient’s entire blood volume in a 24-hour period.
or
• The transfusion of more than 20u of whole blood or 40u of PRBC.
or
• The replacement of over 50% of circulating blood volume in 3 hour or less
or
• Loss of blood or more than 150ml/min
Blood component
– Whole blood: 250ml. containing PRBC 1u, FFP 1u and 30ml preservatives.
– PRBC: ~100ml. Hct 70~80%. PRBC 1u can increase Hb 0.5 (Hct 1.5)
– FFP: ~125ml. Containing coagulation factor, protein and plasma.
– PLT: ~25ml. PLT 12u can increase PLT 60000.
31. INDICATIONS FOR BLOOD COMPONENT
Component Indication Usual starting dose
Whole blood
RBC
Platelets
Fresh frozen plasma
Cryoprecipitate
Blood loss > 1500ml
Blood loss < 1000ml,
Replacement of oxygen-
carrying capacity
Thrombocytopenia or
thrombasthenia with bleeding
Documented coagulopathy
Coagulopathy with low
fibrinogen
better than PRBC + FFP.
Packed 2–4 Units
2–6 Units
10-15 Units
10–20 Units
32. Complications of Blood Transfusion
• O2 Transport
– Shift to left in O2-Hb dissociation curve so RBC's have increased affinity for oxygen
and there is less available to tissues.
– Warm blood and avoid other things that shift O2-Hb dissociation curve to the left
such as alkalosis (bicarb) and hypothermia.
• Transfusions Reactions
• Citrate Intoxication and Hyperkalemia
• Hypothermia
• Acid-Base Disturbances
• Microaggregates
• Infectivity-Hepatitis, HIV, CMV, Syphilis
• Dilutional Coagulopathy
• Volume overload.
33. Complication Mechanisms Management
Coagulopathy •Dilution
•Depletion
•Disseminated Intravascular
Coagulation (DIC)
•Monitor patient coagulation
parameters If INR/aPTT is ≥ 1.5-2.0
consider transfusing FFP
•If fibrinogen is < 1.0 g/L consider
transfusing cryoprecipitate
Thrombocytopenia •Dilution
•Depletion
•DIC
•Monitor patient platelet counts If
platelet count falls below 50 000/cu
consider transfusing platelets
Hypothermia •Infusion of cold IV fluids
and blood products
•Monitor patient temperature
Consider warming the patient and/or
blood components
Hypocalcemia •Calcium chelation by
citrate
•Monitor the patient for arrhythmias
and calcium levels Initiate
intravenous calcium therapy
Hyperkalemia •Rapid transfusion of older
cells (potassium
concentration increases in
RBC units with storage time)
Monitor patient electrolytes and ECG;
consider treatment to lower serum
potassium
Metabolic Acidosis •Shock
•Acid pH of blood
Monitor patient pH, and correct
imbalance
35. Class I Class II Class III Class IV
Blood loss (ml) ≤750 750-1500 1500-2000 >2000
% blood loss ≤15 15-30 30-40 >40
Heart rate (bpm) <100 >100 >120 >140
SBP N N ↓ ↓
Pulse pressure N or ↑ ↓ ↓ ↓
Cap Refill < 3 sec > 3 sec >3 sec or absent absent
Resp rate/ min 14-20 20-30 30-40 <35
Urine output
(ml/hr)
>30 20-30 5-15 Negligible
Mental status Slightly
anxious
Mildly anxious Anxious and
confused
Confused and
lethargic
Treatment 1 – 2 L
crystalloid, +
maintenance
2 L crystalloid,
re-evaluate
2 L crystalloid, re-evaluate, replace blood
loss 1:3 crystalloid, 1:1 colloid or blood
products. Urine output >0.5 mL/kg/hr
CLASSIFICATION OF HEMORRHAGIC SHOCK