High-Capacity Capture of a Recombinant Growth Factor Directly From Refold Sol...Merck Life Sciences
In this work, the authors evaluate a salt tolerant tentacle resin targeting the purification of biomolecules from feeds at high salt concentration:
• Reviews process challenges presented by recombinant growth factors which are commonly expressed in E. coli as inclusion bodies
• Demonstrates how a salt tolerant resin facilitates easy process development with straightforward binding and elution conditions
• Presents cost analysis that compares salt tolerant with conventional cation exchanger for the growth factor purification
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.merckmillipore.com/mlab
New pharmacy rules 'should reduce dispensing mistakes'| Jason Geschwindjasongeschwindmmn
Medication Errors happen and no fault reporting will help avoid the mistakes from happen again to avoid the mistakes to go unreported. That way we will know what areas need attention to come up with solution to prevent them from happening again.
Under the guidance of owner Maher Ishak, Woodbury Pharmacy in Highland Mills, New York was equipped with the ScriptPro Robot dispensing system to automate its in-house pharmaceutical services. When pharmacies decide to automate with ScriptPro, the company sends experienced technicians to install the system and address any issues, ensuring it is calibrated to the same settings used in testing. The technicians then provide training to pharmacy employees in groups and oversee operations as the pharmacy transitions to being fully automated.
Cookeville Regional Medical Center in Cookeville, TN implemented pharmacy automation solutions from McKesson to improve patient safety, workforce productivity, and costs. The solutions included Horizon Meds Manager for order processing, PakPlus-Rx for packaging, ROBOT-Rx for automated dispensing, and MedCarousel for picking. This led to a 99.9% medication dispensing accuracy, avoiding over $1 million in potential adverse drug events annually, and a projected 136.5% return on investment over five years. The pharmacy director was initially reluctant but became convinced of the benefits of automation for patient care.
Case study stlukes(anesthesia)-the final frontier of automationanesthesiarx
Saint Luke's Hospital in Kansas City, Missouri implemented Anesthesia-Rx automated medication dispensing carts to improve their anesthesia medication management and distribution process. The carts provide ready access to medications including controlled substances at the point of care in operating rooms. This has improved inventory management and medication security while reducing pharmacy workload. Anesthesiologists appreciate having needed medications conveniently available in the operating room. The automated solution integrates with the hospital's existing McKesson medication management technology for efficiency. The implementation has realized benefits such as reduced pharmacy time, improved charge capture and identification of medication use and discrepancies.
Baptist Health Systems: Uses Technology to Improve Medication Management, Eli...clinicalsolutions
Baptist Health Systems uses McKesson Nursing Documentation to improve medication management and administration.
http://www.mckesson.com/en_us/McKesson.com/For%2BHealthcare%2BProviders/Hospitals/Nursing%2BSolutions/Nursing%2BSolutions.html
High-Capacity Capture of a Recombinant Growth Factor Directly From Refold Sol...Merck Life Sciences
In this work, the authors evaluate a salt tolerant tentacle resin targeting the purification of biomolecules from feeds at high salt concentration:
• Reviews process challenges presented by recombinant growth factors which are commonly expressed in E. coli as inclusion bodies
• Demonstrates how a salt tolerant resin facilitates easy process development with straightforward binding and elution conditions
• Presents cost analysis that compares salt tolerant with conventional cation exchanger for the growth factor purification
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.merckmillipore.com/mlab
New pharmacy rules 'should reduce dispensing mistakes'| Jason Geschwindjasongeschwindmmn
Medication Errors happen and no fault reporting will help avoid the mistakes from happen again to avoid the mistakes to go unreported. That way we will know what areas need attention to come up with solution to prevent them from happening again.
Under the guidance of owner Maher Ishak, Woodbury Pharmacy in Highland Mills, New York was equipped with the ScriptPro Robot dispensing system to automate its in-house pharmaceutical services. When pharmacies decide to automate with ScriptPro, the company sends experienced technicians to install the system and address any issues, ensuring it is calibrated to the same settings used in testing. The technicians then provide training to pharmacy employees in groups and oversee operations as the pharmacy transitions to being fully automated.
Cookeville Regional Medical Center in Cookeville, TN implemented pharmacy automation solutions from McKesson to improve patient safety, workforce productivity, and costs. The solutions included Horizon Meds Manager for order processing, PakPlus-Rx for packaging, ROBOT-Rx for automated dispensing, and MedCarousel for picking. This led to a 99.9% medication dispensing accuracy, avoiding over $1 million in potential adverse drug events annually, and a projected 136.5% return on investment over five years. The pharmacy director was initially reluctant but became convinced of the benefits of automation for patient care.
Case study stlukes(anesthesia)-the final frontier of automationanesthesiarx
Saint Luke's Hospital in Kansas City, Missouri implemented Anesthesia-Rx automated medication dispensing carts to improve their anesthesia medication management and distribution process. The carts provide ready access to medications including controlled substances at the point of care in operating rooms. This has improved inventory management and medication security while reducing pharmacy workload. Anesthesiologists appreciate having needed medications conveniently available in the operating room. The automated solution integrates with the hospital's existing McKesson medication management technology for efficiency. The implementation has realized benefits such as reduced pharmacy time, improved charge capture and identification of medication use and discrepancies.
Baptist Health Systems: Uses Technology to Improve Medication Management, Eli...clinicalsolutions
Baptist Health Systems uses McKesson Nursing Documentation to improve medication management and administration.
http://www.mckesson.com/en_us/McKesson.com/For%2BHealthcare%2BProviders/Hospitals/Nursing%2BSolutions/Nursing%2BSolutions.html
This document summarizes automated drug dispensing systems. It discusses dispensing processes and environments. Outpatient services refer to non-hospitalized patients visiting for consultations, while inpatient services refer to hospitalized patients receiving total pharmaceutical care. Common inpatient drug dispensing methods are individual prescription ordering, complete floor stocking, mobile dispensing, and unit dose dispensing like CUDDS and DUDDS. Automated dispensing involves robotic systems that store and retrieve medications automatically for improved safety, efficiency, and stock control. While advantages include faster filling and less errors, disadvantages include costs and technical skills required.
Medical Associates Clinic is a large multi-specialty practice in Iowa that was using inefficient paper-based processes. They implemented McKesson's Horizon Ambulatory Care EHR to improve communication and workflow. Initial results included a 40-80% reduction in transcription costs within 2 weeks for some specialties. Once fully implemented, the EHR is projected to save over $1.7 million annually through reduced paper/transcription costs and improved coding accuracy. Physicians can now document visits electronically, improving patient care.
Medical Associates Clinic is a large multi-specialty practice in Iowa that was using inefficient paper-based processes. They implemented McKesson's Horizon Ambulatory Care EHR to improve communication and workflow. Initial results included a 40-80% reduction in transcription costs within 2 weeks for some specialties. Once fully implemented, the EHR is projected to save over $1.7 million annually through reduced paper/transcription costs and improved coding accuracy. Physicians can now document visits electronically, improving patient care.
Discover how a large healthcare provider was able to decrease lost anesthesia drug charges by 40% and improve patient safety through improved Anesthesia management
Successfully Piloting a Virtual Real-World Evidence Study Case StudyCovance
A mid-sized pharmaceutical company needed to conduct a completely virtual study and asked Covance to support their efforts based on their past experience with virtual real-world evidence programs.
Credit Suisse First Boston Annual Health Care Conference Presentationfinance2
Paul Julian, president of McKesson Supply Solutions, presented at the CSFB 2003 Global Healthcare Conference. He discussed McKesson's mission to advance healthcare success through partnerships. McKesson offers comprehensive products, technology, and services across multiple divisions. Julian highlighted McKesson's strategy of leveraging its size, customer base, and solutions to improve quality and reduce costs. Financial results for the second quarter and first half of fiscal year 2004 showed revenue growth and increased profitability.
Montgomery General Hospital Achieves Successguest9dfe8f9
Montgomery General Hospital implemented McKesson's Horizon Medical Imaging PACS to improve efficiency in their emergency department and radiology workflows. The PACS reduced report turnaround times from 54 hours to 18 hours, increased patient throughput, and allowed radiologists to access diagnostic images and reports enterprise-wide. Physicians could now view radiology reports immediately to inform treatment decisions. The PACS also improved weekly cancer conferences by enabling projection of images and reports. Overall the system helped reallocate resources to better support patient care.
Integrates McKesson PACS with Nuance Voice to Reduce Report TATs and Improve ...mckessonmedicalimaging
Main Line Health implemented McKesson's PACS and integrated it with Nuance's voice recognition software to reduce radiology report turnaround times from 23 hours to 2 hours. This allowed radiologists to view images and sign off on 85% of reports immediately instead of waiting until later for transcription. The faster report times allowed attending physicians to make clinical decisions much sooner and improved patient care. Some radiologists could self-edit up to 90% of cases. The system was easy for radiologists to use and reduced the need to review cases again later for accuracy.
McKesson Provider Technologies held an investor briefing in 2006 to highlight their performance and differentiation. They discussed strong financial performance with revenue up 19% and operating profit up 56%. They are proud of wins at Duke University Health System and Triad Hospitals and progress in the UK and France. McKesson aims to give customers the power to lead through physician access, image-enabled care, eliminating medication errors, and driving evidence-based care. Their comprehensive approach and clinical and performance leadership solutions provide clear differentiation in the market.
Using clinical co-management to improve quality and keep physiciansCurtis Bernstein
Reviews governmental direction for the development of clinical co-management agreements; Describes appropriate structure and development of fair market value compensation for services provided under a clinical co-management agreement.
McKesson provides concise summaries of their business in 3 sentences:
McKesson is a leading healthcare services and information technology company with the #1 market share in pharmaceutical distribution, automation solutions, and medical-surgical supplies. They leverage their scale across business units like Pharmaceutical Solutions, Information Solutions, and Medical-Surgical Solutions to improve clinical outcomes and reduce costs for customers through their "One McKesson" strategy of comprehensive offerings and services. McKesson reported solid financial results for Q2 and the first half of FY04 with revenue growth of 14% and 27% EPS growth, driven by strong performance in Pharmaceutical Solutions.
Following post approval changes, all oral products including control release (CR) ones need to be assured of batch to batch consistency of quality as well as consistency of in-vivo release and in turn of clinical performance. Product assay and dissolution do not have mechanistic and statistical properties to be able to predict clinical performance of a batch of a CR product. In-vitro-in-vivo correlations (IVIVC), however, are the predictive, mathematical models relating an in vitro property such as dissolution and an in vivo response, e.g., amount of drug absorbed, thus allowing an evaluation of the QC specifications, change in process, site, formulation and application for a biowaiver etc.
Biopharmaceutics Classification System (BCS) offers an easy but non-robust IVIVC such that the drugs of high permeability and high or low solubility drugs (Class I and II) are expected and indeed show different levels of reliable correlation. Owing to their high absorption numbers and rate limiting dissolution these drugs exhibit IVIVC. Classes III and IV rarely show such correlation. Deconvolution and convolution are mathematical modeling methods based on compartmental mass balance and non-compartmental superposition, respectively. If assumptions are upheld, these methods also give very reliable IVIVC. Illustrative examples will be given in the presentation.
A review of biorelevant dissolution testing, in vivo study design and the predictability of IVIVC model will be presented. Examples of CR products showing IVIVC and their actual applications will be described with human and animal data. Finally, prediction error for relevant pharmacokinetic parameters will be discussed.
This document discusses in-vitro-in-vivo correlations (IVIVC) for oral controlled release products. It covers the relevance and definition of IVIVC, levels of IVIVC, methods for generating in-vitro and in-vivo release profiles, predictability of IVIVC models, and issues related to IVIVC modeling. The key points are that biorelevant dissolution testing can predict in vivo absorption if IVIVC is established, several mathematical models can be used to estimate in vivo release profiles, and IVIVC is useful for quality control but has practical and modeling challenges that must be addressed.
The document provides an outline of key information about hospital pharmacy including:
1) It defines hospital pharmacy as the department that procures, stores, dispenses, and distributes drugs in a hospital under the supervision of a qualified pharmacist.
2) It lists the main functions of hospital pharmacy such as purchasing drugs, proper storage, manufacturing medications, dispensing prescriptions, and providing drug information.
3) The objectives of hospital pharmacy are to ensure the availability of correct medications at low cost, professionalize pharmaceutical services, provide counseling, and participate in research and teaching.
The Oakwood Healthcare system implemented an electronic health record (EHR) system across its clinics with the help of Dell Services to improve efficiency and physician satisfaction. Dell Services used its proven ADOPTS methodology to plan and implement the EHR solution. This streamlined processes, allowing physicians to access patient medical records instantly. Physicians were now able to make quick medical decisions and improve patient care. The implementation was completed on time and under budget. Oakwood saw improved efficiency, enhanced patient care, and increased physician satisfaction after adopting the EHR system with Dell Services' support.
This presentation describes mehtods of fraud detection, which can save a slef insured company an average of $1,654 per workers compensation claim, same quarter savings. It also describes techniques, using Internet based tests, developed by a team of doctors from Johns Hopkins Hospital, which improve diagnoses, resulting in increased return to work rate, a 90% reduction in the use of medication, and a 45% reduction in doctor visits, with documented cost savings of $20,000 to $175,000 for long test cases. See slideshare presentation
http://www.slideshare.net/DiagnoseMyPain/patient-cost-savings-documented-with-letters for documentation.
The AcuDose-Rx automated dispensing cabinet from McKesson offers several key benefits: it optimizes medication inventory to reduce stockouts, supports nurses' mobile workflows, and protects the investment with upgrades and world-class support. The cabinets use McKesson's RightStock system to automatically adjust inventory levels and prevent stockouts. Nurses can quickly find and access medications through intuitive navigation and dispensing by scheduled time. The cabinets also integrate with clinical systems to provide closed-loop medication administration records.
Case Study: Clinical Trial Management System (ASCEND) ImplementationPerficient
Axcan Pharma is a specialty pharmaceutical company that needed a scalable clinical trial management system (CTMS) to support its growing research and development division. The company implemented BioPharm Systems' ASCEND CTMS accelerator, which met most of its needs out of the box and provided additional functionality at a lower cost than a custom Siebel Clinical solution. Axcan Pharma is pleased with ASCEND, which has helped streamline processes and eliminate redundancies. After a successful first year, Axcan Pharma will partner further with BioPharm Systems for additional configuration changes and potential system integrations.
PILSrx, from Procurement to Patient, how the Australian Defence Force maximis...Ocean Software
PILSrx is the Pharmaceutical Integrated Logistics software that is used by Australia's Defence Forces to manage the supply chain of all the pharmaceuticals procured by the ADF and distributed to personnel.
This presentation was recently delivered at the MILCIS 2017 conference by Ocean Software MD, Mr Bruce Moors.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
This document summarizes automated drug dispensing systems. It discusses dispensing processes and environments. Outpatient services refer to non-hospitalized patients visiting for consultations, while inpatient services refer to hospitalized patients receiving total pharmaceutical care. Common inpatient drug dispensing methods are individual prescription ordering, complete floor stocking, mobile dispensing, and unit dose dispensing like CUDDS and DUDDS. Automated dispensing involves robotic systems that store and retrieve medications automatically for improved safety, efficiency, and stock control. While advantages include faster filling and less errors, disadvantages include costs and technical skills required.
Medical Associates Clinic is a large multi-specialty practice in Iowa that was using inefficient paper-based processes. They implemented McKesson's Horizon Ambulatory Care EHR to improve communication and workflow. Initial results included a 40-80% reduction in transcription costs within 2 weeks for some specialties. Once fully implemented, the EHR is projected to save over $1.7 million annually through reduced paper/transcription costs and improved coding accuracy. Physicians can now document visits electronically, improving patient care.
Medical Associates Clinic is a large multi-specialty practice in Iowa that was using inefficient paper-based processes. They implemented McKesson's Horizon Ambulatory Care EHR to improve communication and workflow. Initial results included a 40-80% reduction in transcription costs within 2 weeks for some specialties. Once fully implemented, the EHR is projected to save over $1.7 million annually through reduced paper/transcription costs and improved coding accuracy. Physicians can now document visits electronically, improving patient care.
Discover how a large healthcare provider was able to decrease lost anesthesia drug charges by 40% and improve patient safety through improved Anesthesia management
Successfully Piloting a Virtual Real-World Evidence Study Case StudyCovance
A mid-sized pharmaceutical company needed to conduct a completely virtual study and asked Covance to support their efforts based on their past experience with virtual real-world evidence programs.
Credit Suisse First Boston Annual Health Care Conference Presentationfinance2
Paul Julian, president of McKesson Supply Solutions, presented at the CSFB 2003 Global Healthcare Conference. He discussed McKesson's mission to advance healthcare success through partnerships. McKesson offers comprehensive products, technology, and services across multiple divisions. Julian highlighted McKesson's strategy of leveraging its size, customer base, and solutions to improve quality and reduce costs. Financial results for the second quarter and first half of fiscal year 2004 showed revenue growth and increased profitability.
Montgomery General Hospital Achieves Successguest9dfe8f9
Montgomery General Hospital implemented McKesson's Horizon Medical Imaging PACS to improve efficiency in their emergency department and radiology workflows. The PACS reduced report turnaround times from 54 hours to 18 hours, increased patient throughput, and allowed radiologists to access diagnostic images and reports enterprise-wide. Physicians could now view radiology reports immediately to inform treatment decisions. The PACS also improved weekly cancer conferences by enabling projection of images and reports. Overall the system helped reallocate resources to better support patient care.
Integrates McKesson PACS with Nuance Voice to Reduce Report TATs and Improve ...mckessonmedicalimaging
Main Line Health implemented McKesson's PACS and integrated it with Nuance's voice recognition software to reduce radiology report turnaround times from 23 hours to 2 hours. This allowed radiologists to view images and sign off on 85% of reports immediately instead of waiting until later for transcription. The faster report times allowed attending physicians to make clinical decisions much sooner and improved patient care. Some radiologists could self-edit up to 90% of cases. The system was easy for radiologists to use and reduced the need to review cases again later for accuracy.
McKesson Provider Technologies held an investor briefing in 2006 to highlight their performance and differentiation. They discussed strong financial performance with revenue up 19% and operating profit up 56%. They are proud of wins at Duke University Health System and Triad Hospitals and progress in the UK and France. McKesson aims to give customers the power to lead through physician access, image-enabled care, eliminating medication errors, and driving evidence-based care. Their comprehensive approach and clinical and performance leadership solutions provide clear differentiation in the market.
Using clinical co-management to improve quality and keep physiciansCurtis Bernstein
Reviews governmental direction for the development of clinical co-management agreements; Describes appropriate structure and development of fair market value compensation for services provided under a clinical co-management agreement.
McKesson provides concise summaries of their business in 3 sentences:
McKesson is a leading healthcare services and information technology company with the #1 market share in pharmaceutical distribution, automation solutions, and medical-surgical supplies. They leverage their scale across business units like Pharmaceutical Solutions, Information Solutions, and Medical-Surgical Solutions to improve clinical outcomes and reduce costs for customers through their "One McKesson" strategy of comprehensive offerings and services. McKesson reported solid financial results for Q2 and the first half of FY04 with revenue growth of 14% and 27% EPS growth, driven by strong performance in Pharmaceutical Solutions.
Following post approval changes, all oral products including control release (CR) ones need to be assured of batch to batch consistency of quality as well as consistency of in-vivo release and in turn of clinical performance. Product assay and dissolution do not have mechanistic and statistical properties to be able to predict clinical performance of a batch of a CR product. In-vitro-in-vivo correlations (IVIVC), however, are the predictive, mathematical models relating an in vitro property such as dissolution and an in vivo response, e.g., amount of drug absorbed, thus allowing an evaluation of the QC specifications, change in process, site, formulation and application for a biowaiver etc.
Biopharmaceutics Classification System (BCS) offers an easy but non-robust IVIVC such that the drugs of high permeability and high or low solubility drugs (Class I and II) are expected and indeed show different levels of reliable correlation. Owing to their high absorption numbers and rate limiting dissolution these drugs exhibit IVIVC. Classes III and IV rarely show such correlation. Deconvolution and convolution are mathematical modeling methods based on compartmental mass balance and non-compartmental superposition, respectively. If assumptions are upheld, these methods also give very reliable IVIVC. Illustrative examples will be given in the presentation.
A review of biorelevant dissolution testing, in vivo study design and the predictability of IVIVC model will be presented. Examples of CR products showing IVIVC and their actual applications will be described with human and animal data. Finally, prediction error for relevant pharmacokinetic parameters will be discussed.
This document discusses in-vitro-in-vivo correlations (IVIVC) for oral controlled release products. It covers the relevance and definition of IVIVC, levels of IVIVC, methods for generating in-vitro and in-vivo release profiles, predictability of IVIVC models, and issues related to IVIVC modeling. The key points are that biorelevant dissolution testing can predict in vivo absorption if IVIVC is established, several mathematical models can be used to estimate in vivo release profiles, and IVIVC is useful for quality control but has practical and modeling challenges that must be addressed.
The document provides an outline of key information about hospital pharmacy including:
1) It defines hospital pharmacy as the department that procures, stores, dispenses, and distributes drugs in a hospital under the supervision of a qualified pharmacist.
2) It lists the main functions of hospital pharmacy such as purchasing drugs, proper storage, manufacturing medications, dispensing prescriptions, and providing drug information.
3) The objectives of hospital pharmacy are to ensure the availability of correct medications at low cost, professionalize pharmaceutical services, provide counseling, and participate in research and teaching.
The Oakwood Healthcare system implemented an electronic health record (EHR) system across its clinics with the help of Dell Services to improve efficiency and physician satisfaction. Dell Services used its proven ADOPTS methodology to plan and implement the EHR solution. This streamlined processes, allowing physicians to access patient medical records instantly. Physicians were now able to make quick medical decisions and improve patient care. The implementation was completed on time and under budget. Oakwood saw improved efficiency, enhanced patient care, and increased physician satisfaction after adopting the EHR system with Dell Services' support.
This presentation describes mehtods of fraud detection, which can save a slef insured company an average of $1,654 per workers compensation claim, same quarter savings. It also describes techniques, using Internet based tests, developed by a team of doctors from Johns Hopkins Hospital, which improve diagnoses, resulting in increased return to work rate, a 90% reduction in the use of medication, and a 45% reduction in doctor visits, with documented cost savings of $20,000 to $175,000 for long test cases. See slideshare presentation
http://www.slideshare.net/DiagnoseMyPain/patient-cost-savings-documented-with-letters for documentation.
The AcuDose-Rx automated dispensing cabinet from McKesson offers several key benefits: it optimizes medication inventory to reduce stockouts, supports nurses' mobile workflows, and protects the investment with upgrades and world-class support. The cabinets use McKesson's RightStock system to automatically adjust inventory levels and prevent stockouts. Nurses can quickly find and access medications through intuitive navigation and dispensing by scheduled time. The cabinets also integrate with clinical systems to provide closed-loop medication administration records.
Case Study: Clinical Trial Management System (ASCEND) ImplementationPerficient
Axcan Pharma is a specialty pharmaceutical company that needed a scalable clinical trial management system (CTMS) to support its growing research and development division. The company implemented BioPharm Systems' ASCEND CTMS accelerator, which met most of its needs out of the box and provided additional functionality at a lower cost than a custom Siebel Clinical solution. Axcan Pharma is pleased with ASCEND, which has helped streamline processes and eliminate redundancies. After a successful first year, Axcan Pharma will partner further with BioPharm Systems for additional configuration changes and potential system integrations.
PILSrx, from Procurement to Patient, how the Australian Defence Force maximis...Ocean Software
PILSrx is the Pharmaceutical Integrated Logistics software that is used by Australia's Defence Forces to manage the supply chain of all the pharmaceuticals procured by the ADF and distributed to personnel.
This presentation was recently delivered at the MILCIS 2017 conference by Ocean Software MD, Mr Bruce Moors.
Similar to Nursing, Pharmacy Benefit from ROBOT-Rx Medication Dispensing Solution (20)
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Lecture 6 -- Memory 2015.pptlearning occurs when a stimulus (unconditioned st...AyushGadhvi1
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Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Cell Therapy Expansion and Challenges in Autoimmune Disease
Nursing, Pharmacy Benefit from ROBOT-Rx Medication Dispensing Solution
1. Case Study
At a Glance
Organization
Evergreen Hospital Medical Center
Evergreen Hospital Nursing, Pharmacy Benefit from ROBOT-Rx
Medical Center
Kirkland, WA Medication Dispensing Solution
Solution Spotlight Overview increasing labor shortages and
– ROBOT-Rx® Officials at Evergreen Hospital higher labor costs, Blanchard sought
Medical Center sought to prepare for to streamline processes through
– AcuDose-Rx®
bar code medication administration automation. But he also wanted to
– Packaging Solutions balance automation with the desire
and improve efficiency of medication
– MedDirect™ delivery to nurse servers. By to continue using nurse servers.
implementing the ROBOT-Rx®
Critical Issues system, the hospital increased Answers
– Reduce the risk of medication dispensing accuracy to 99.9 percent; After an extensive review of various
errors cut cart fill labor by 72 percent; and medication distribution models,
– Position for bar code medication realized nearly $2 million in annual Evergreen chose to automate existing
administration savings via 24,000 pharmacist-patient processes. "We already were
interventions. successful in terms of delivering unit-
– Support existing nurse server
model dose medications to the bedside,"
Challenges explained Blanchard. "It became a
– Reduce laborious cart fill and Located on the outskirts of Seattle, matter of streamlining pharmacy
first dose operations the 250-bed Evergreen Hospital is a operations so that our staffing is
– Improve efficiency in a tight community-based facility serving a most efficient. The ROBOT-Rx®
labor market growing population of more than system is the obvious solution." The
400,000 people. For more than 15 ROBOT-Rx system automates
Results years, nurses at Evergreen Hospital medication storage, dispensing,
– Improved medication dispensing Medical Center were accustomed to returning, restocking, and crediting.
accuracy to 99.9% retrieving unit-dose medications
from nurse server units. To fill the Evergreen began by packaging
– Conducted nearly 24,000 clinical
nurse servers with unit-dose medications in bar-coded, unit-dose
interventions annually, saving
medications, the pharmacy form using McKesson equipment.
approximately $1.9 million
performed a daily manual cart fill. "Because the packaging looks similar,
– Cut first dose fill labor by 78% Selecting and checking the 1,125 we wanted to get nurses accustomed
– Reduced cart fill labor by 72% daily doses took nearly 15 hours for to using it—to be able to distinguish
technicians and pharmacists. what a Protonix dose looks like
– Decreased crediting labor by
versus a digoxin, for instance. It was
50%
"The nurses liked the convenience of a smooth transition." After building
– Strengthened narcotics having scheduled and common PRN its bar-coded medication stock,
management medications as close as possible to Evergreen went live with ROBOT-Rx
the bedside, as opposed to walking in March 2004. "At first, we
to the medication room down the conducted a short trial with our
hall," explained Bob Blanchard, pharmacists checking every dose the
director of pharmacy. "It's good for robot dispensed," explained
nursing workflow and safer, but the Blanchard. "Now we do a daily 10
cart fill was a very labor-intensive percent random check, with approval
process for pharmacy." Faced with of the state Board of Pharmacy."