Not so long ago, youth- seemed to be irreplaceable and temporary; however, today everything has changed-with the help of scientists with more than 30 years of experiments and studies about the human ageing process, truly amazing products have been discovered, based on the natural peptides. Peptides are very short proteins, which are made from amino acids. Peptides are the major components for human kind.
All living processes happen with the help of peptides or so called molecules of life!
Peptides have major anti-ageing effect on human cells thus preventing different types of diseases and curing the existing once. Also, they carry out protecting actions against toxins and other damaging factors and support levels of mature and active cells as well as their metabolism. With the help of peptides, cells life expectancy increases from 30% to 40%. In average, people live up to 75 years, using up to 30% of energy for living resources and fighting against toxic environmental factors; such as: ecology, stress and ultraviolet radiation. Also, the life style factors play a crucial role in human life expectancy- food, water and exercise. Most of us do not have a healthy diet, we do not consume clean water, our life style is not active enough and we don have a clear regime for rest. All of these listed factors lead to changes in our genes and as a result, we age so quickly; therefore, decreases our live expectancy up to 30% or 40%.
Peptides products have no contraindications and you can not get addicted to them. Nowadays, such products are one of the most popular ways anti-ageing which is affordable for everyone. Products from NPCRIZ are time turned around, without surgery or harmful consequences.
The document discusses peptide bioregulators and their potential role in slowing the aging process. It describes research by Dr. Khavinson showing that peptides are important for communication between cells and body systems. With aging, peptide production declines, disrupting communication and cellular functions. Dr. Khavinson developed peptide bioregulator products extracted from young animals that can restore peptide levels and cellular regeneration to slow aging.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Metabolic Adaptations: The Physiology of Cold Acclimatization and Exercise in...InsideScientific
Metabolic Adaptations to Exercise: Role of NAMPT and NAD+ in Skeletal Muscle
Jonas Treebak, PhD
NAD+ is a cofactor implicated in important metabolic reactions, such as oxidative phosphorylation. One of the highest rates of mitochondrial respiration is found in contracting skeletal muscle. Nicotinamide phosphoribosyltransferase (NAMPT) is essential for skeletal muscle NAD+ synthesis. Skeletal muscle-specific knockout of Nampt (SMNKO) reduces skeletal muscle NAD+ levels by 85-90%.This leads to mitochondrial dysfunction, energy deficiency, poor contractility, low exercise performance, and progressive muscle degeneration. The Treebak lab generated inducible SMNKO mice (iSMNKO) and achieved a comparable depletion of NAD+. iSMNKO mice did not show altered mitochondrial respiratory capacity at rest or after exercise in isolated intact fibers. Moreover, high resolution respirometry in mitochondria isolated from iSMNKO muscle exhibited unchanged respiration and ATP synthesis, as well as normal P/O and mitochondrial membrane potential. Interestingly, iSMNKO skeletal muscle has lower capacity for succinate-induced mitochondrial ROS production compared to the wildtype control. iSMNKO mice displayed normal VO2 at rest and during an acute bout of maximal exercise, they behaved similarly in response to prolonged voluntary wheel (VW) running, but failed to increase performance after VW training. Collectively, their data demonstrate that the role of NAD in mitochondrial function may be more nuanced than is often thought.
Cold Acclimatization – Fundamental Mechanisms and Popular Misconceptions
Alexander Bartelt, PhD
Homeotherm mammals like rodents or humans regulate their body temperature by means of thermogenesis. Below the thermoneutral zone, where basal metabolism is sufficient to maintain homeothermy, thermogenic mechanisms are activated to contribute to heat production. This adaptation to cold exposure is a phasic process with acute activation of existing stores, acquisition of extra nutrients as fuels, and finally extensive remodeling of cells, tissues, and physiology, altogether facilitating cold acclimatization. Most notably are shivering and non-shivering thermogenesis by myocytes and thermogenic adipocytes, respectively. In this seminar, Dr. Bartelt provides an overview of the phasic process of cold acclimatization, elaborates on novel, fundamental mechanisms, including his lab’s own work on the transcription factor Nfe2l1, and, finally, highlights misconceptions that are frequently found in the literature.
Pathology is the study of disease processes and changes in cells, tissues, and organs. It serves as the bridge between basic sciences and clinical medicine. There are four aspects of disease studied in pathology: etiology, pathogenesis, morphologic changes, and clinical manifestations. Cellular changes in disease can include reversible changes like hypertrophy, hyperplasia, atrophy and metaplasia which allow cell survival. Irreversible cell injury leads to cell death by necrosis or apoptosis. Necrosis is characterized by cellular swelling, membrane rupture and inflammatory cell death, while apoptosis is a regulated form of cell death.
This document summarizes a study that investigated how mechanical forces applied to integrin receptors control intracellular signaling in osteoblasts. The researchers found that cyclic forces applied to the beta-1 integrin subunit at 1 Hz were more effective at stimulating calcium responses in osteoblasts than continuous forces. Cyclic forces also induced increased tyrosine phosphorylation of cytoskeleton-anchored proteins and greater activation of focal adhesion kinase and mitogen-activated protein kinase compared to continuous forces. These responses depended on an intact cytoskeleton and the presence of intracellular calcium. Analysis of spatial calcium signals revealed they originated near the stressed receptors, indicating cells can sense local stress via integrins.
Ways to Raise Immune System with Comprehensive Constitutional Homeopathy Prog...Bruce Shelton
Issues related to Fibromyalgia, Brain Imbalance and Disease, Irritable Bowel Syndrome, Leaky Gut Syndrome and Migraine Symptoms stem from a miscommunication between the cerebral neurons that regulate pain reception and those that control vascular dilation and constriction.
The Brain and Spine must be properly balanced (or “calibrated”). If the brain and spine are not communicating properly, then no treatment modality will have full effect or may be completely ineffectual. Additionally, sarcodes are dilutions of healthy tissue that drive a remedy toward that organ. DesBio and Dr. Bruce Shelton have created a full line of homeopathic remedies to heal the whole body...we call it Comprehensive Homeopathy.
DesBio products are available only through healthcare practitioners. For more information on Comprehensive Homeopathy visit visit www.Desbio.com or phone 1-800-827-9529. If you are a consumer, please visit homeopathic remedies (www.DrBsRemedies.com) for a new line of homeopathic remedies available to the public.
Evaluation of the Impact of Biofield Treatment on Physical and Thermal Proper...wilhelm mendel
In the present study, the influence of biofield treatment on physical and thermal properties of Casein Enzyme Hydrolysate (CEH) and Casein Yeast Peptone (CYP) were investigated. The control and treated samples were characterized by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), Thermo Gravimetric Analysis (TGA), particle size and surface area analysis. The FTIR results revealed that biofield treatment has caused reduction of amide group (amide-I and amide-II) stretching vibration peak that is associated with strong intermolecular hydrogen bonding in treated CEH as compared to control. However, no significant changes were observed in FTIR spectrum of treated CYP. The TGA analysis of treated CEH showed a substantial improvement in thermal stability which was confirmed by increase in maximum thermal decomposition temperature (217°C) as compared to control (209°C). Similarly, the treated CYP also showed enhanced thermal stability as compared to control. DSC showed increase in melting temperature of treated CYP as compared to control. However the melting peak was absent in DSC of treated CEH which was probably due to rigid chain of the protein. The surface area of treated CEH was increased by 83% as compared to control. However, a decrease (7.3%) in surface area was observed in treated CYP. The particle size analysis of treated CEH showed a significant increase in average particle size (d50) and d99 value (maximum particle size below which 99% of particles are present) as compared to control sample. Similarly, the treated CYP also showed a substantial increase in d50 and d99 values which was probably due to the agglomeration of the particles which led to formation of bigger microparticles. The result showed that the biofield treated CEH and CYP could be used as a matrix for pharmaceutical applications.
Rheumatoid arthritis is a chronic inflammatory and systemic auto immune disease affecting people for the most part
between the ages of 20-25 yrs with accidental course. About 1% of the worlds population is afflicted by rheumatoid
arthritis and is 2-3 times more common in women than men. The rheumatoid arthritis due to the presence of pro
inflammatory markers, cytokines and leukotrines. The primary inflammatory markers are IL-1, TNF-α, IL-6, IL-15,
IL-16, IL-17, IL-18, IFN-γ, and the granulocyte macrophage colony stimulating factor, chemokines such as IL-8,
macrophage inflammatory protein-1 and monocyte chemo attractant protein-1. IL-1, TNF-α, IL-6, B cells therapy all
these blockade are therapeutic target for its treatment. estimate the anti arthritic activity of the plants are used in
different animal models to induced arthritis. Medicinal plants have been used as major sources of pure of human
diseases since time immemorial. Now a days most of the people depends on traditional medicines of the plants. The
medicinal plants derived medicines for the first time of primary health care because of least or no side effects.
The document discusses peptide bioregulators and their potential role in slowing the aging process. It describes research by Dr. Khavinson showing that peptides are important for communication between cells and body systems. With aging, peptide production declines, disrupting communication and cellular functions. Dr. Khavinson developed peptide bioregulator products extracted from young animals that can restore peptide levels and cellular regeneration to slow aging.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Metabolic Adaptations: The Physiology of Cold Acclimatization and Exercise in...InsideScientific
Metabolic Adaptations to Exercise: Role of NAMPT and NAD+ in Skeletal Muscle
Jonas Treebak, PhD
NAD+ is a cofactor implicated in important metabolic reactions, such as oxidative phosphorylation. One of the highest rates of mitochondrial respiration is found in contracting skeletal muscle. Nicotinamide phosphoribosyltransferase (NAMPT) is essential for skeletal muscle NAD+ synthesis. Skeletal muscle-specific knockout of Nampt (SMNKO) reduces skeletal muscle NAD+ levels by 85-90%.This leads to mitochondrial dysfunction, energy deficiency, poor contractility, low exercise performance, and progressive muscle degeneration. The Treebak lab generated inducible SMNKO mice (iSMNKO) and achieved a comparable depletion of NAD+. iSMNKO mice did not show altered mitochondrial respiratory capacity at rest or after exercise in isolated intact fibers. Moreover, high resolution respirometry in mitochondria isolated from iSMNKO muscle exhibited unchanged respiration and ATP synthesis, as well as normal P/O and mitochondrial membrane potential. Interestingly, iSMNKO skeletal muscle has lower capacity for succinate-induced mitochondrial ROS production compared to the wildtype control. iSMNKO mice displayed normal VO2 at rest and during an acute bout of maximal exercise, they behaved similarly in response to prolonged voluntary wheel (VW) running, but failed to increase performance after VW training. Collectively, their data demonstrate that the role of NAD in mitochondrial function may be more nuanced than is often thought.
Cold Acclimatization – Fundamental Mechanisms and Popular Misconceptions
Alexander Bartelt, PhD
Homeotherm mammals like rodents or humans regulate their body temperature by means of thermogenesis. Below the thermoneutral zone, where basal metabolism is sufficient to maintain homeothermy, thermogenic mechanisms are activated to contribute to heat production. This adaptation to cold exposure is a phasic process with acute activation of existing stores, acquisition of extra nutrients as fuels, and finally extensive remodeling of cells, tissues, and physiology, altogether facilitating cold acclimatization. Most notably are shivering and non-shivering thermogenesis by myocytes and thermogenic adipocytes, respectively. In this seminar, Dr. Bartelt provides an overview of the phasic process of cold acclimatization, elaborates on novel, fundamental mechanisms, including his lab’s own work on the transcription factor Nfe2l1, and, finally, highlights misconceptions that are frequently found in the literature.
Pathology is the study of disease processes and changes in cells, tissues, and organs. It serves as the bridge between basic sciences and clinical medicine. There are four aspects of disease studied in pathology: etiology, pathogenesis, morphologic changes, and clinical manifestations. Cellular changes in disease can include reversible changes like hypertrophy, hyperplasia, atrophy and metaplasia which allow cell survival. Irreversible cell injury leads to cell death by necrosis or apoptosis. Necrosis is characterized by cellular swelling, membrane rupture and inflammatory cell death, while apoptosis is a regulated form of cell death.
This document summarizes a study that investigated how mechanical forces applied to integrin receptors control intracellular signaling in osteoblasts. The researchers found that cyclic forces applied to the beta-1 integrin subunit at 1 Hz were more effective at stimulating calcium responses in osteoblasts than continuous forces. Cyclic forces also induced increased tyrosine phosphorylation of cytoskeleton-anchored proteins and greater activation of focal adhesion kinase and mitogen-activated protein kinase compared to continuous forces. These responses depended on an intact cytoskeleton and the presence of intracellular calcium. Analysis of spatial calcium signals revealed they originated near the stressed receptors, indicating cells can sense local stress via integrins.
Ways to Raise Immune System with Comprehensive Constitutional Homeopathy Prog...Bruce Shelton
Issues related to Fibromyalgia, Brain Imbalance and Disease, Irritable Bowel Syndrome, Leaky Gut Syndrome and Migraine Symptoms stem from a miscommunication between the cerebral neurons that regulate pain reception and those that control vascular dilation and constriction.
The Brain and Spine must be properly balanced (or “calibrated”). If the brain and spine are not communicating properly, then no treatment modality will have full effect or may be completely ineffectual. Additionally, sarcodes are dilutions of healthy tissue that drive a remedy toward that organ. DesBio and Dr. Bruce Shelton have created a full line of homeopathic remedies to heal the whole body...we call it Comprehensive Homeopathy.
DesBio products are available only through healthcare practitioners. For more information on Comprehensive Homeopathy visit visit www.Desbio.com or phone 1-800-827-9529. If you are a consumer, please visit homeopathic remedies (www.DrBsRemedies.com) for a new line of homeopathic remedies available to the public.
Evaluation of the Impact of Biofield Treatment on Physical and Thermal Proper...wilhelm mendel
In the present study, the influence of biofield treatment on physical and thermal properties of Casein Enzyme Hydrolysate (CEH) and Casein Yeast Peptone (CYP) were investigated. The control and treated samples were characterized by Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), Thermo Gravimetric Analysis (TGA), particle size and surface area analysis. The FTIR results revealed that biofield treatment has caused reduction of amide group (amide-I and amide-II) stretching vibration peak that is associated with strong intermolecular hydrogen bonding in treated CEH as compared to control. However, no significant changes were observed in FTIR spectrum of treated CYP. The TGA analysis of treated CEH showed a substantial improvement in thermal stability which was confirmed by increase in maximum thermal decomposition temperature (217°C) as compared to control (209°C). Similarly, the treated CYP also showed enhanced thermal stability as compared to control. DSC showed increase in melting temperature of treated CYP as compared to control. However the melting peak was absent in DSC of treated CEH which was probably due to rigid chain of the protein. The surface area of treated CEH was increased by 83% as compared to control. However, a decrease (7.3%) in surface area was observed in treated CYP. The particle size analysis of treated CEH showed a significant increase in average particle size (d50) and d99 value (maximum particle size below which 99% of particles are present) as compared to control sample. Similarly, the treated CYP also showed a substantial increase in d50 and d99 values which was probably due to the agglomeration of the particles which led to formation of bigger microparticles. The result showed that the biofield treated CEH and CYP could be used as a matrix for pharmaceutical applications.
Rheumatoid arthritis is a chronic inflammatory and systemic auto immune disease affecting people for the most part
between the ages of 20-25 yrs with accidental course. About 1% of the worlds population is afflicted by rheumatoid
arthritis and is 2-3 times more common in women than men. The rheumatoid arthritis due to the presence of pro
inflammatory markers, cytokines and leukotrines. The primary inflammatory markers are IL-1, TNF-α, IL-6, IL-15,
IL-16, IL-17, IL-18, IFN-γ, and the granulocyte macrophage colony stimulating factor, chemokines such as IL-8,
macrophage inflammatory protein-1 and monocyte chemo attractant protein-1. IL-1, TNF-α, IL-6, B cells therapy all
these blockade are therapeutic target for its treatment. estimate the anti arthritic activity of the plants are used in
different animal models to induced arthritis. Medicinal plants have been used as major sources of pure of human
diseases since time immemorial. Now a days most of the people depends on traditional medicines of the plants. The
medicinal plants derived medicines for the first time of primary health care because of least or no side effects.
This document provides an overview of various experimental animal models that are used to induce different disease conditions and evaluate potential treatments. It discusses models for inflammatory diseases, pyrexia, arrhythmias, hypertension, diabetes, hyperlipidemia, and tests for assessing central nervous system activity, muscle relaxation, sedation, anxiety, seizures, convulsions, and analgesia. Examples of specific animal models and procedures are provided for each condition. The models described allow for studying disease pathogenesis and testing new drug candidates before human trials.
Thermal and Physical Properties of Biofield Treated Bile Salt and Proteose Pe...Mahendra Kumar Trivedi
Bile salt (BS) and proteose peptone (PP) are important biomacromolecules being produced inside the human body. The objective of this study was to investigate the influence of biofield treatment on physicochemical properties of BS and PP. The study was performed in two groups (control and treated). The control group remained as untreated, and biofield treatment was given to treated group. The control and treated BS and PP samples were characterized by particle size analyzer (PSA), Brunauer-Emmett-Teller (BET) analysis, differential scanning calorimetry (DSC), x-ray diffraction (XRD), and thermogravimetric analysis (TGA). PSA results showed increase in particle size (d50 and d99) of both treated BS and PP as compared to control. Surface area analysis showed minimal decrease by 1.59%, in surface area of treated BS as compared to control. However, the treated PP showed increase (8%) in surface area as compared to control. DSC characterization showed increase in melting temperature of treated BS as compared to control. Whereas, DSC thermogram of treated PP showed decrease in melting temperature with respect to control. Moreover, the DSC of control and treated PP showed presence of exothermic peaks which were possibly due to protein aggregation. The treated PP showed higher exothermic transition temperature as compared to control. XRD analysis revealed slight reduction in crystalline nature of BS as compared to control. On the other hand, XRD data of control and treated PP showed an amorphous nature. TGA analysis of treated BS showed maximum thermaldecomposition temperature at 22°C which was higher as compared to control sample (106°C). This could be due to biofield treatment which may enhance the thermal stability of treated BS with respect to control. However, the TGA thermogram of treated PP showed decrease in maximum thermal stability as compared to control. The overall results showed that biofield treatment has significantly altered the physical and thermal properties of BS and PP.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Algae-Based Astaxanthin superior to Synthetic and Phaffia Yeast AstaxanthinAlgaeHealthSciences
This document discusses the differences between natural astaxanthin from algae and synthetic or Phaffia yeast-derived astaxanthin. It summarizes several studies that show natural astaxanthin is significantly more effective as an antioxidant, protecting animals from oxidative stress better than the other forms. One study on C. elegans worms found natural astaxanthin kept 50% more alive after oxidative stress and improved antioxidant enzyme levels more than the other groups. Another study on rats also showed natural astaxanthin better protected the liver and had higher antioxidant effects. In general, the document argues natural astaxanthin is superior for health applications based on its stronger antioxidant activity and better outcomes in animal studies compared to synthetic or Ph
This study evaluated the effects of dexamethasone (DXM) therapy on the inflammatory response in experimental pneumococcal meningitis. In a rabbit model:
1) DXM prevented increases in cerebrospinal fluid (CSF) white blood cells and lactate when given 30 minutes before, but not 1 hour after, pneumococcal cell wall extract administration.
2) With live pneumococcal meningitis, DXM modulated antibiotic-induced CSF tumor necrosis factor-α and lactate increases only in animals with initial CSF bacterial levels over 5.6 log10 cfu/mL.
3) DXM effects were independent of whether it was given 30 minutes before or 1 hour after the
The document describes the regenerative medicine clinic of Dr. David Steenblock, who pioneers the use of bone marrow stem cell therapy and other treatments. The clinic offers bone marrow stem cell harvesting and intravenous infusions to treat various conditions such as Parkinson's disease, stroke, heart disease, and aging. The document outlines complementary therapies used at the clinic including hyperbaric oxygen therapy, laser therapy, electromagnetic therapy and more. It provides several patient examples and research on the benefits of stem cell therapy for various diseases and anti-aging.
This study investigated how insulin deficiency affects mitochondrial oxidative phosphorylation in the hearts of diabetic mice. The key findings were:
1) Activity of oxidative phosphorylation complex V (ATP synthase) was significantly reduced in the hearts of streptozotocin-induced diabetic mice.
2) Normalizing blood glucose with phlorizin treatment did not improve complex V activity, but insulin treatment did normalize it, indicating the reduction was caused by insulin deficiency rather than hyperglycemia.
3) Acute insulin stimulation induced phosphorylation and translocation of Akt to mitochondria in heart muscle. This translocation was enhanced in diabetic mice and blocked inhibition of Akt, blunting the activation of complex V by insulin.
Adaptogens are herbs and plants that help the body adapt to stress by balancing cortisol levels and modulating the fight or flight response. They work at the cellular level to allow cells full access to energy and promote healthy functioning. Russian scientist Dr. Israel Brekhman pioneered the study of adaptogens, discovering eleutherococcus (Siberian ginseng) which he termed the "King of Adaptogens". Brekhman conducted extensive human testing of adaptogens which demonstrated benefits like improved sleep, immune function, focus and recovery from stress or exercise. Adaptogens were also found to help Russian astronauts and athletes by restoring balance and protecting against stress.
This document discusses research on the neuroprotective properties of natural astaxanthin. It summarizes studies showing that astaxanthin protects brain cells by preventing DNA damage and supporting mitochondrial function. Specifically, human research found that astaxanthin improved markers of dementia and cognitive function in elderly subjects. Additional pre-clinical research substantiated these findings. The document also discusses astaxanthin's strong antioxidant and anti-inflammatory activities, and how these contribute to its neuroprotective effects. It concludes that astaxanthin is a promising nutrient for maintaining brain health with age due to its ability to cross the blood-brain barrier and its demonstrated neuroprotective activities.
This document summarizes a study that investigated the expression of melatonin receptor proteins (MT1 and MT2) in the thyroid gland of male mice at different ages, and measured levels of thyroxine (T4) and thyrotropin (TSH) hormones. The study found that aged mice had decreased levels of serum T4 but unchanged levels of serum TSH compared to young mice. Expression of both MT1 and MT2 melatonin receptor proteins in the thyroid gland decreased with age. This suggests that aging modulates the responsiveness of the thyroid gland to melatonin through changes in melatonin receptor expression, which may contribute to declining thyroid function in older organisms.
This document summarizes a study examining the effects of high glucose and diabetes on cellular proteasome function in retinal and kidney cells. The key findings are:
1) Retinal endothelial cells exhibited significantly higher proteasome peptidase activity compared to pericytes and other cell types. High glucose treatment increased proteasome activity in endothelial cells but decreased it in pericytes.
2) High glucose treatment increased total levels of ubiquitinated proteins in retinal pericytes and endothelial cells, but not in photoreceptor cells. It also elevated levels of the PA28-a/-b proteasome regulatory subunits in pericytes and other cell types.
3) Retinas from diabetic mice showed
In vivo studies of wound healing and hepatoprotective agentsAdarsh Patil
1) Various in vivo models are used to evaluate wound healing and hepatoprotective activity, including excision wounds, incision wounds, and burn wounds in rats.
2) Parameters like wound contraction, epithelization time, tensile strength and histopathology are measured to assess wound healing.
3) Hepatoprotective activity is evaluated by pre-treating animals with the test substance before inducing liver damage using toxins like CCl4, D-galactosamine, or paracetamol. Liver function is then assessed through serum enzymes and histopathology.
Effects of atorvastatin and streptozocin on immunohistochemical markers in hi...Ram Sahu
This study investigated the effects of atorvastatin on immunohistochemical markers in the hippocampus of rats with a streptozocin-induced model of Alzheimer's disease. The results showed that streptozocin increased glial fibrillary acidic protein and neuronal nitric oxide synthase in the hippocampus compared to controls. Atorvastatin treatment at 20 mg/kg reduced glial fibrillary acidic protein levels compared to streptozocin alone. Atorvastatin at doses of 5, 10, and 20 mg/kg increased glutathione reductase expression compared to streptozocin alone. Atorvastatin at 10 and 20 mg/kg also reduced neuronal nitric oxide synthase levels compared to streptozocin alone.
This study investigated the effects of L-alpha-glycerylphosphorylcholine (GPC), a deacylated derivative of phosphatidylcholine (PC), in a rat model of small intestinal ischemia-reperfusion injury. The results showed that:
1) Intestinal ischemia-reperfusion increased oxidative stress markers, microcirculatory dysfunction, and liver ATP depletion.
2) Both pre-treatment and post-treatment with GPC significantly reduced oxidative stress markers, protected microcirculation, and alleviated hepatic ATP depletion caused by ischemia-reperfusion.
3) GPC therapies were effective in attenuating the inflammatory response to ischemia-reperfusion injury, providing indirect
A Multimodal, Regenerative Approach to TBI including HBOT and Adult Stem CellsMegan Hughes
Dr. Hughes presents at the 2018 OMED conference in San Diego about treating TBI using intranasal therapies, hyperbaric oxygen, the ketogenic diet, IV nutrition, and supplementation. He also discusses how HBOT upregulates peripheral blood stem cells.
1) The study examined the effects of repeated MDMA exposure on glutamate release and parvalbumin-positive GABAergic cells in the rat hippocampus.
2) Treatment with non-selective and COX-2 selective cyclooxygenase inhibitors attenuated the MDMA-induced increase in hippocampal glutamate, but a COX-1 inhibitor did not.
3) Repeated MDMA exposure reduced the number of parvalbumin-positive GABA interneurons in the hippocampus, and this effect was attenuated by a cyclooxygenase inhibitor. However, the inhibitor did not prevent MDMA-induced depletion of serotonin in the hippocampus.
This study investigated how hypoxia and lipopolysaccharide (LPS) affect autophagy in mouse-derived dendritic cells. The researchers found that hypoxia induced autophagy in the cells, as evidenced by increased autophagosome formation and expression of autophagy-related proteins LC3, Beclin1, and HIF-1α. Administration of LPS under hypoxic conditions further enhanced autophagy flux. Hypoxia upregulates HIF-1α, which plays an important role in activating autophagy. This study provides insight into how hypoxic environments stimulate autophagy in dendritic cells through the HIF-1α pathway and how LPS can augment
Transgenic Animals A Better Approach towards Experimentationijtsrd
Animals play a crucial role in the development of medical products from medicines to various implants and major surgical procedures. They are not approved for human use until they qualify the safety parameters in animals. The animals play a pivotal role in drug discovery and development. One of the most challenging aspects of targeting drugs for any pathological condition is the development of animal models. Animal models are nothing but an approach to replicate the general symptoms of the diseased condition which occur in humans. The whole pathophysiology cannot be replicated but, the symptoms which are known and precipitate the most in any pathological condition are positively reproduced within the animal. With the increasing need in the medical field, the paradigm is now slowly shifting towards transgenic animals as they have given a new dimension to medical sciences to study the pathophysiology of the disease rather than focusing on the symptom based analysis of the diseased condition. These genetically modified organisms have shown groundbreaking results not only in developing models for various diseases but also in developing biopharmaceuticals, receptor selective drugs, and have a huge contribution to xenotransplantation and the agriculture sector. This review article vividly describes the newer approaches that are adopted to develop transgenic animal models and also highlights certain limitations to the older approach of developing the models. Swarnima Negi | Dr. Sachdev Yadav "Transgenic Animals: A Better Approach towards Experimentation" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38268.pdf Paper Url: https://www.ijtsrd.com/pharmacy/pharmacology-/38268/transgenic-animals-a-better-approach-towards-experimentation/swarnima-negi
1) The document discusses DNA repair mechanisms in cells and the role of proteins like Chk1 and its smaller sibling Chk1-S in regulating cell division and DNA replication.
2) It describes how the inflammatory mediator PGE2 contributes to colorectal cancer by increasing methylation and shutting down tumor suppressor genes and DNA repair genes. Using anti-inflammatory and demethylating drugs together was shown to significantly reduce tumor growth in mice.
3) DNA repair mechanisms and apoptosis help maintain health by allowing cells to adapt to changes and remove mutated cells, while deficiencies can lead to diseases like cancer if mutations accumulate.
Protandim is a dietary supplement created by LifeVantage that activates the Nrf2 pathway in the body. Nrf2 is known as the "master regulator" of the body's antioxidant defenses. By activating Nrf2, Protandim stimulates the body's natural production of antioxidant enzymes like superoxide dismutase, glutathione, and catalase that can neutralize cellular damage from free radicals. Protandim contains a proprietary blend of plant extracts including turmeric, bacopa, ashwagandha, green tea, and milk thistle. Clinical studies show Protandim can significantly increase antioxidant enzyme levels and reduce cellular stress within 30 days.
The document discusses biotechnology approaches for aging, including stem cell rejuvenation by targeting sirtuins, telomerase activation to lengthen telomeres, senolytic therapies to clear senescent cells, and hydrogen therapy. Recent advancements include improved curcumin delivery for anti-aging, using lymph nodes to grow replacement organs, quantum computing for drug design, oral drugs for weight loss and neuroinflammation, immune cell therapies for cancer, wearable brain monitoring, and potential ways to repair Alzheimer's damage. The future may see prolonging ovarian function by modulating anti-Müllerian hormone levels.
This document provides an overview of various experimental animal models that are used to induce different disease conditions and evaluate potential treatments. It discusses models for inflammatory diseases, pyrexia, arrhythmias, hypertension, diabetes, hyperlipidemia, and tests for assessing central nervous system activity, muscle relaxation, sedation, anxiety, seizures, convulsions, and analgesia. Examples of specific animal models and procedures are provided for each condition. The models described allow for studying disease pathogenesis and testing new drug candidates before human trials.
Thermal and Physical Properties of Biofield Treated Bile Salt and Proteose Pe...Mahendra Kumar Trivedi
Bile salt (BS) and proteose peptone (PP) are important biomacromolecules being produced inside the human body. The objective of this study was to investigate the influence of biofield treatment on physicochemical properties of BS and PP. The study was performed in two groups (control and treated). The control group remained as untreated, and biofield treatment was given to treated group. The control and treated BS and PP samples were characterized by particle size analyzer (PSA), Brunauer-Emmett-Teller (BET) analysis, differential scanning calorimetry (DSC), x-ray diffraction (XRD), and thermogravimetric analysis (TGA). PSA results showed increase in particle size (d50 and d99) of both treated BS and PP as compared to control. Surface area analysis showed minimal decrease by 1.59%, in surface area of treated BS as compared to control. However, the treated PP showed increase (8%) in surface area as compared to control. DSC characterization showed increase in melting temperature of treated BS as compared to control. Whereas, DSC thermogram of treated PP showed decrease in melting temperature with respect to control. Moreover, the DSC of control and treated PP showed presence of exothermic peaks which were possibly due to protein aggregation. The treated PP showed higher exothermic transition temperature as compared to control. XRD analysis revealed slight reduction in crystalline nature of BS as compared to control. On the other hand, XRD data of control and treated PP showed an amorphous nature. TGA analysis of treated BS showed maximum thermaldecomposition temperature at 22°C which was higher as compared to control sample (106°C). This could be due to biofield treatment which may enhance the thermal stability of treated BS with respect to control. However, the TGA thermogram of treated PP showed decrease in maximum thermal stability as compared to control. The overall results showed that biofield treatment has significantly altered the physical and thermal properties of BS and PP.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Algae-Based Astaxanthin superior to Synthetic and Phaffia Yeast AstaxanthinAlgaeHealthSciences
This document discusses the differences between natural astaxanthin from algae and synthetic or Phaffia yeast-derived astaxanthin. It summarizes several studies that show natural astaxanthin is significantly more effective as an antioxidant, protecting animals from oxidative stress better than the other forms. One study on C. elegans worms found natural astaxanthin kept 50% more alive after oxidative stress and improved antioxidant enzyme levels more than the other groups. Another study on rats also showed natural astaxanthin better protected the liver and had higher antioxidant effects. In general, the document argues natural astaxanthin is superior for health applications based on its stronger antioxidant activity and better outcomes in animal studies compared to synthetic or Ph
This study evaluated the effects of dexamethasone (DXM) therapy on the inflammatory response in experimental pneumococcal meningitis. In a rabbit model:
1) DXM prevented increases in cerebrospinal fluid (CSF) white blood cells and lactate when given 30 minutes before, but not 1 hour after, pneumococcal cell wall extract administration.
2) With live pneumococcal meningitis, DXM modulated antibiotic-induced CSF tumor necrosis factor-α and lactate increases only in animals with initial CSF bacterial levels over 5.6 log10 cfu/mL.
3) DXM effects were independent of whether it was given 30 minutes before or 1 hour after the
The document describes the regenerative medicine clinic of Dr. David Steenblock, who pioneers the use of bone marrow stem cell therapy and other treatments. The clinic offers bone marrow stem cell harvesting and intravenous infusions to treat various conditions such as Parkinson's disease, stroke, heart disease, and aging. The document outlines complementary therapies used at the clinic including hyperbaric oxygen therapy, laser therapy, electromagnetic therapy and more. It provides several patient examples and research on the benefits of stem cell therapy for various diseases and anti-aging.
This study investigated how insulin deficiency affects mitochondrial oxidative phosphorylation in the hearts of diabetic mice. The key findings were:
1) Activity of oxidative phosphorylation complex V (ATP synthase) was significantly reduced in the hearts of streptozotocin-induced diabetic mice.
2) Normalizing blood glucose with phlorizin treatment did not improve complex V activity, but insulin treatment did normalize it, indicating the reduction was caused by insulin deficiency rather than hyperglycemia.
3) Acute insulin stimulation induced phosphorylation and translocation of Akt to mitochondria in heart muscle. This translocation was enhanced in diabetic mice and blocked inhibition of Akt, blunting the activation of complex V by insulin.
Adaptogens are herbs and plants that help the body adapt to stress by balancing cortisol levels and modulating the fight or flight response. They work at the cellular level to allow cells full access to energy and promote healthy functioning. Russian scientist Dr. Israel Brekhman pioneered the study of adaptogens, discovering eleutherococcus (Siberian ginseng) which he termed the "King of Adaptogens". Brekhman conducted extensive human testing of adaptogens which demonstrated benefits like improved sleep, immune function, focus and recovery from stress or exercise. Adaptogens were also found to help Russian astronauts and athletes by restoring balance and protecting against stress.
This document discusses research on the neuroprotective properties of natural astaxanthin. It summarizes studies showing that astaxanthin protects brain cells by preventing DNA damage and supporting mitochondrial function. Specifically, human research found that astaxanthin improved markers of dementia and cognitive function in elderly subjects. Additional pre-clinical research substantiated these findings. The document also discusses astaxanthin's strong antioxidant and anti-inflammatory activities, and how these contribute to its neuroprotective effects. It concludes that astaxanthin is a promising nutrient for maintaining brain health with age due to its ability to cross the blood-brain barrier and its demonstrated neuroprotective activities.
This document summarizes a study that investigated the expression of melatonin receptor proteins (MT1 and MT2) in the thyroid gland of male mice at different ages, and measured levels of thyroxine (T4) and thyrotropin (TSH) hormones. The study found that aged mice had decreased levels of serum T4 but unchanged levels of serum TSH compared to young mice. Expression of both MT1 and MT2 melatonin receptor proteins in the thyroid gland decreased with age. This suggests that aging modulates the responsiveness of the thyroid gland to melatonin through changes in melatonin receptor expression, which may contribute to declining thyroid function in older organisms.
This document summarizes a study examining the effects of high glucose and diabetes on cellular proteasome function in retinal and kidney cells. The key findings are:
1) Retinal endothelial cells exhibited significantly higher proteasome peptidase activity compared to pericytes and other cell types. High glucose treatment increased proteasome activity in endothelial cells but decreased it in pericytes.
2) High glucose treatment increased total levels of ubiquitinated proteins in retinal pericytes and endothelial cells, but not in photoreceptor cells. It also elevated levels of the PA28-a/-b proteasome regulatory subunits in pericytes and other cell types.
3) Retinas from diabetic mice showed
In vivo studies of wound healing and hepatoprotective agentsAdarsh Patil
1) Various in vivo models are used to evaluate wound healing and hepatoprotective activity, including excision wounds, incision wounds, and burn wounds in rats.
2) Parameters like wound contraction, epithelization time, tensile strength and histopathology are measured to assess wound healing.
3) Hepatoprotective activity is evaluated by pre-treating animals with the test substance before inducing liver damage using toxins like CCl4, D-galactosamine, or paracetamol. Liver function is then assessed through serum enzymes and histopathology.
Effects of atorvastatin and streptozocin on immunohistochemical markers in hi...Ram Sahu
This study investigated the effects of atorvastatin on immunohistochemical markers in the hippocampus of rats with a streptozocin-induced model of Alzheimer's disease. The results showed that streptozocin increased glial fibrillary acidic protein and neuronal nitric oxide synthase in the hippocampus compared to controls. Atorvastatin treatment at 20 mg/kg reduced glial fibrillary acidic protein levels compared to streptozocin alone. Atorvastatin at doses of 5, 10, and 20 mg/kg increased glutathione reductase expression compared to streptozocin alone. Atorvastatin at 10 and 20 mg/kg also reduced neuronal nitric oxide synthase levels compared to streptozocin alone.
This study investigated the effects of L-alpha-glycerylphosphorylcholine (GPC), a deacylated derivative of phosphatidylcholine (PC), in a rat model of small intestinal ischemia-reperfusion injury. The results showed that:
1) Intestinal ischemia-reperfusion increased oxidative stress markers, microcirculatory dysfunction, and liver ATP depletion.
2) Both pre-treatment and post-treatment with GPC significantly reduced oxidative stress markers, protected microcirculation, and alleviated hepatic ATP depletion caused by ischemia-reperfusion.
3) GPC therapies were effective in attenuating the inflammatory response to ischemia-reperfusion injury, providing indirect
A Multimodal, Regenerative Approach to TBI including HBOT and Adult Stem CellsMegan Hughes
Dr. Hughes presents at the 2018 OMED conference in San Diego about treating TBI using intranasal therapies, hyperbaric oxygen, the ketogenic diet, IV nutrition, and supplementation. He also discusses how HBOT upregulates peripheral blood stem cells.
1) The study examined the effects of repeated MDMA exposure on glutamate release and parvalbumin-positive GABAergic cells in the rat hippocampus.
2) Treatment with non-selective and COX-2 selective cyclooxygenase inhibitors attenuated the MDMA-induced increase in hippocampal glutamate, but a COX-1 inhibitor did not.
3) Repeated MDMA exposure reduced the number of parvalbumin-positive GABA interneurons in the hippocampus, and this effect was attenuated by a cyclooxygenase inhibitor. However, the inhibitor did not prevent MDMA-induced depletion of serotonin in the hippocampus.
This study investigated how hypoxia and lipopolysaccharide (LPS) affect autophagy in mouse-derived dendritic cells. The researchers found that hypoxia induced autophagy in the cells, as evidenced by increased autophagosome formation and expression of autophagy-related proteins LC3, Beclin1, and HIF-1α. Administration of LPS under hypoxic conditions further enhanced autophagy flux. Hypoxia upregulates HIF-1α, which plays an important role in activating autophagy. This study provides insight into how hypoxic environments stimulate autophagy in dendritic cells through the HIF-1α pathway and how LPS can augment
Transgenic Animals A Better Approach towards Experimentationijtsrd
Animals play a crucial role in the development of medical products from medicines to various implants and major surgical procedures. They are not approved for human use until they qualify the safety parameters in animals. The animals play a pivotal role in drug discovery and development. One of the most challenging aspects of targeting drugs for any pathological condition is the development of animal models. Animal models are nothing but an approach to replicate the general symptoms of the diseased condition which occur in humans. The whole pathophysiology cannot be replicated but, the symptoms which are known and precipitate the most in any pathological condition are positively reproduced within the animal. With the increasing need in the medical field, the paradigm is now slowly shifting towards transgenic animals as they have given a new dimension to medical sciences to study the pathophysiology of the disease rather than focusing on the symptom based analysis of the diseased condition. These genetically modified organisms have shown groundbreaking results not only in developing models for various diseases but also in developing biopharmaceuticals, receptor selective drugs, and have a huge contribution to xenotransplantation and the agriculture sector. This review article vividly describes the newer approaches that are adopted to develop transgenic animal models and also highlights certain limitations to the older approach of developing the models. Swarnima Negi | Dr. Sachdev Yadav "Transgenic Animals: A Better Approach towards Experimentation" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38268.pdf Paper Url: https://www.ijtsrd.com/pharmacy/pharmacology-/38268/transgenic-animals-a-better-approach-towards-experimentation/swarnima-negi
1) The document discusses DNA repair mechanisms in cells and the role of proteins like Chk1 and its smaller sibling Chk1-S in regulating cell division and DNA replication.
2) It describes how the inflammatory mediator PGE2 contributes to colorectal cancer by increasing methylation and shutting down tumor suppressor genes and DNA repair genes. Using anti-inflammatory and demethylating drugs together was shown to significantly reduce tumor growth in mice.
3) DNA repair mechanisms and apoptosis help maintain health by allowing cells to adapt to changes and remove mutated cells, while deficiencies can lead to diseases like cancer if mutations accumulate.
Protandim is a dietary supplement created by LifeVantage that activates the Nrf2 pathway in the body. Nrf2 is known as the "master regulator" of the body's antioxidant defenses. By activating Nrf2, Protandim stimulates the body's natural production of antioxidant enzymes like superoxide dismutase, glutathione, and catalase that can neutralize cellular damage from free radicals. Protandim contains a proprietary blend of plant extracts including turmeric, bacopa, ashwagandha, green tea, and milk thistle. Clinical studies show Protandim can significantly increase antioxidant enzyme levels and reduce cellular stress within 30 days.
The document discusses biotechnology approaches for aging, including stem cell rejuvenation by targeting sirtuins, telomerase activation to lengthen telomeres, senolytic therapies to clear senescent cells, and hydrogen therapy. Recent advancements include improved curcumin delivery for anti-aging, using lymph nodes to grow replacement organs, quantum computing for drug design, oral drugs for weight loss and neuroinflammation, immune cell therapies for cancer, wearable brain monitoring, and potential ways to repair Alzheimer's damage. The future may see prolonging ovarian function by modulating anti-Müllerian hormone levels.
Biology, genetics, nanotechnology, neuroscience, materials science, biotech, ...Brian Russell
Over the past two years I've done a lot of interesting research which I've decided to aggregate. My research pertains to the following: Biology, Genetics, Nanotechnology, Neuroscience, Materials Science, Biotechnology, Chemical Engineering, All Things 3-D, Super Computing, Quantum Physics, Energy, Design, & Sustainability.
Learn about the possibilities of what Adult Stem Cell pose for the future of curing chronic disease, cancers, and how nutrition plays a part in their ability to keeping you healthy.
NuVerus Plus is a potent antioxidant supplement derived from plants. Clinical testing shows it has one of the highest ORAC scores in history, indicating strong antioxidant properties, and the CAP-e test found it highly effective at protecting live cells from oxidative damage. NuVerus Plus contains plant chemicals that studies show can help fight cancer, diabetes, epilepsy, asthma, high blood pressure, and more. Experts recommend consuming 18,000 ORAC units daily for optimal health, which is achieved through 2 ounces of NuVerus Plus.
An 8 year old boy, a case of Duchenne Muscular Dystrophy who presented with symptoms of generalized weakness of the body, falling down often, inability to climb stairs except by using all four limbs to do so, inability to play, ride the bicycle or carry his own bag to school and abnormal fatigue was started on Intent Healing(™) Remote healing sessions. At the end of 15 sessions the Creatine Phosphokinase (CPK) levels in his blood decreased from 24,000 IU/L(the value before healing sessions were started) to 7,500 IU/L . His symptoms improved with the healing sessions and he is now able to carry his own bag to school, has not had a fall, is able to ride the bicycle and play games in school and has sustained energy throughout the day with no fatigue.
Scientists have successfully converted human skin cells into insulin-producing pancreatic cells, representing a breakthrough that could lead to personalized cell therapy for diabetics. The new cells produced insulin in response to glucose levels and prevented diabetes in mice. This technique can be scaled up to produce trillions of pancreatic cells through controlled processes. The finding opens opportunities to analyze patient-specific pancreatic cell properties and optimize cell therapy approaches.
Use of creatine in normal or pathological conditions of muscle and brainMaurizio Balestrino
Creatine plays an important role in energy storage and transport in muscles and the brain. The document summarizes research showing that creatine supplementation can benefit conditions involving energy deficiency in these tissues, including neurological diseases, vegetarian diets, muscle diseases, aging, fatigue, and hypoxia. Doses of 5-20g per day have been used safely in studies. However, creatine preparations vary in quality so a pure version like Creapure is recommended.
Ganoderma ,Reshi, Mushroom,Lingzhi, are the same name of edible Fungus..Before 2000 years Chinese Medical text book marks it the king medicinal herb.Its medicinal efficacy is proven by modern medical science.It can be used as preventive & curative illness.
Dr.Shebendra karmakar
Ph.D in Natural Medicine,USA
Stem Cell Therapy: The Future is Here! Find Out About the Clinical Trial and ...Patients Medical
Dr. Kamau Kokayi, Director of New York Stem Cell Treatment Center at Patients Medical presents research on how stem cell therapy has helped patients already.
Biotechnology uses living systems to develop useful products. Nano-biopharmaceuticals, also known as biopharmaceuticals or biologics, are medicines extracted or manufactured from biological sources rather than being chemically synthesized, and include vaccines, blood products, gene therapies, and recombinant proteins. They are produced by introducing Chinese hamster ovary cells to reagents that cause the cells to multiply and produce target proteins over several weeks. Biologicals treat various diseases from cancer to Lou Gehrig's disease and some forms of blindness. Nano-biopharmaceuticals are called that because only a small amount is needed to introduce reagents to cells and cause intracellular production of medicines, allowing treatments for previously intractable diseases.
Biotechnology uses microorganisms and cell culture techniques to produce medicines, industrial chemicals, and other useful products. Key applications include using monoclonal antibodies for diagnostics and therapeutics, producing crops with desirable traits through plant cell culture, and generating vaccines and biopharmaceuticals through insect and mammalian cell culture. Emerging technologies like recombinant DNA, cloning, protein engineering, biosensors, nanobiotechnology, and microarrays further expand biotechnology's possibilities in fields like medicine, agriculture, and environmental remediation.
Regenerative cells can be embryonic or adult cells found in tissues. Adult regenerative cells are obtained from tissues like fat and act as the repair system for the body. Regenerative cells can self-renew and differentiate into specialized cells. Research on regenerative cells shows promise but progress is slower than reported. Mesenchymal regenerative cells found in fat and bone marrow can differentiate into multiple cell types and have anti-inflammatory properties, making them a potential therapy for immune-mediated diseases. Adipose-derived regenerative cell treatment involves harvesting stromal vascular fraction cells from fat which contain regenerative cells and growth factors and injecting them back into patients to potentially replace damaged cells and reduce inflammation.
The effects of diethylstilbestrol administration on rat kidney. ultrastructur...Prof. Hesham N. Mustafa
This study examined the effects of diethylstilbestrol (DES) administration on rat kidney tissues over different time periods using histological, immunohistochemical, and ultrastructural analysis. Thirty male rats were divided into three groups: a control group, a group that received 60 μg/kg DES daily for 20 days, and a group that received the same dose of DES for 50 days. DES administration for 50 days caused degeneration of renal tissues, damage to renal tubules, increased cellularity of glomeruli, and a significant increase in BAX protein expression, indicating increased apoptosis. These changes were less pronounced after 20 days of treatment. The study found that non-steroidal synthetic estrogens like DES can have
1) Researchers at Penn State used stem cells and a modified Wnt signaling pathway to generate epicardium and endocardium cells, which could help regenerate the layers of the human heart and improve quality of life for heart attack patients.
2) A rare and severe form of encephalitis called anti-NMDA receptor encephalitis attacks NMDA receptors in the brain; a new treatment using the drug Bortezomib was found to successfully reduce antibodies and symptoms by inhibiting proteasomes.
3) Advances in regenerating heart cells and treating difficult diseases bring hope and move humanity forward as medical solutions are found for problems that were previously intractable.
It is about aging and how aging is tried to controlled by different sort of methods and animals models are used in the testing the products created by science. It explains the different theories of aging in a very detailed manner. And the very least includes different animal models like mouse and monkey on which these treatments are applied and checked the effects of them that how we can control aging. We, can never say that controlling aging is something about that we are becoming immortal it is totally about finding the factors which can reduce tha aging and aging related diseases.
Biography and career history of Bruno AmezcuaBruno Amezcua
Bruno Amezcua's entry into the film and visual arts world seemed predestined. His grandfather, a distinguished film editor from the 1950s through the 1970s, profoundly influenced him. This familial mentorship early on exposed him to the nuances of film production and a broad array of fine arts, igniting a lifelong passion for narrative creation. Over 15 years, Bruno has engaged in diverse projects showcasing his dedication to the arts.
Insanony: Watch Instagram Stories Secretly - A Complete GuideTrending Blogers
Welcome to the world of social media, where Instagram reigns supreme! Today, we're going to explore a fascinating tool called Insanony that lets you watch Instagram Stories secretly. If you've ever wanted to view someone's story without them knowing, this blog is for you. We'll delve into everything you need to know about Insanony with Trending Blogers!
Amid the constant barrage of distractions and dwindling motivation, self-discipline emerges as the unwavering beacon that guides individuals toward triumph. This vital quality serves as the key to unlocking one’s true potential, whether the aspiration is to attain personal goals, ascend the career ladder, or refine everyday habits.
Understanding Self-Discipline
MISS TEEN LUCKNOW 2024 - WINNER ASIYA 2024DK PAGEANT
In the dynamic city of Lucknow, known for its wealthy social legacy and authentic importance, a youthful star has developed, capturing the hearts of numerous with her elegance, insights, and eagerness. Asiya, as of late delegated as the champ from Lucknow for Miss Youngster India 2024 by the DK Pageant, stands as a confirmation of the monstrous ability and potential dwelling inside the youth of India. This exceptional young lady is a signal of excellence and a paragon of devotion and aspiration.
Confidence is Key: Fashion for Women Over 50miabarn9
Unlock your personal style and confidence at 50 and beyond! Our fashion blog provides actionable tips and inspiration on how to improve your dressing sense according to your body type, skin tone, and personal style, ensuring you look and feel amazing.
MISS RAIPUR 2024 - WINNER POONAM BHARTI.DK PAGEANT
Poonam Bharti, a guide of ability and diligence, has been chosen as the champ from Raipur for Mrs. India 2024, Pride of India, from the DK Show. Her journey to this prestigious title is a confirmation of her commitment, difficult work, and multifaceted gifts. At fair 23 a long time ago, Poonam has as of now made noteworthy strides in both her proficient and individual lives, encapsulating the soul of present-day Indian ladies who adjust different parts with beauty and competence. This article dives into Poonam Bharti’s foundation, achievements, and qualities that separated her as a meriting champion of this award.
2. „there is a realisticpossibilitytocontol the process of human ageing ” The typicalsymptom of ageing, that the body is less abletoadapt. The expalanation is the decreasingfunctions of the body'scells, organs and systems Duringagingoccurmanyirregularitiesin the interaction of the variousorgans and systems. The abnormalinteractionscausethecontroldeclininginbody'sinternalenvironment , and makeweakerandweaker the immunesystem and the self-regulation. During the agingprocess, theresearcherspaidparticularattentiontothechangesoccurringinthe main body systems - the immunesystem, cardiovascular, thecentralnervoussystem, and endocrinesystem. Concluded, thatusing the physiologicaldevicestostimulateaging body, is provenby the modern scientificresults and viewpoint, whichmeansthatthere is a realisticoptionin the management process of human ageing.
3. Thisclaimcomesfrom the St. PetersburgInstitute’s professor, Dr. Khavinson, the world-renownedgeriatrician. Dr. Khavinsonresearchesforseveraldecades the aging process. He publishedhundreds of studies and several booksonit, and 26 monographs and 165 patent owner. Hisapproachbasedon the bioregulatorysysteminthe human body, whichoperatedbycellmediators (peptides). The peptide’sfunction (amongmanyotherthings), is the informationexchange, duringinteractionbetweencells of the immune, nervous, endocrine and other systems. In the pathologicalstate of human organization the informationexchangeprocess is disrupted. As a result, the synthesis and accumulation of the peptides, that transferingdistortedinformation, inhibit the harmoniousfunctioning of the different body systems. The biologicallyactivepeptidesareveryrecommendedregeneratingprotectorsinanyage. Thesepeptidesshould be usedfornormalmetabolicmaintenance, prevention and cure of variousdiseases, rehabilitationafterserious illnesses, injuries, surgery, inordertoslow down body'sagingprocess.
4. Strong scientific background Professor Khavinson, the world-renowned geriatrician of Institute St. Petersburg was the first scientist in the world, who managed to generate peptids,by natural way. Because of his discovery he was nominated for the Nobel price on 28.november 2010. Bioregulátor products we distribute, the fruits of his work.
5. The significance of peptides The peptide’s function is the information exchange, during interaction between cells of the immune, nervous, endocrine and other systems. The peptide Bioregulatorsreconstruct organs, tissues, disrupted functions. The peptid bioregulators restore the regulation of gene activity. How do peptids work? The short peptides are linked to the corresponding genes in specific parts, cause the DNA molecules extracted, and read the data contained therein. Thus comes into being the correction of the tissue, ie cell division without defect.
6. Fontos… The St. Petersburg Institute of Bioregulatory and Gerontology created a completely new, highly efficient technology that extracts low molecular mass peptide fraction, from bodies and tissues of young animals (calves). It has provided an opportunity to be created the new class of natural supplements, includes 7 unique peptid bioregulator products, in addition: the world's first liquid peptide product family, mesotel products, and peptid cell-cosmetic products. (In the picture: Dr. Khavinson in our company’s opening)
7. The products have no side effects, and they work quickly.We can say, that these products, as scientific work of Dr. Khavinson, hold giant and real value, and due to their real reconstruction effect, simply they are inimitable. (Picture: Dr. Khavinson) These products are Dr. Khavinson's unique works, wich available by our company
8. It is important to note: It is important to note that these young animals, not test animals, and nobody causes them pain. An animal operated once in anesthesia. The short operation is not a concern throughout an organ, but a very tiny micro-sized tissue. After the operation the animals are kept in a calm, sterile environment
9. Natural peptids in capsule form According to the NCPRIZ classification, the second class geroprotectors are the cell-bioregulators and cell-regeneratorsd of the different organs, and tissues, consist of natural short peptides. These supplements in capsule form - are complex, consist of peptides, amino acids, vitamins and microparticles.
10. The natural short peptides According to out latest knowledge, the short peptides linked to the corresponding genes in specific parts, causing the DNA molecules extracted, and read the data contained therein. The passage of time and life, evolving peptide deficiency, significantly accelerates wear on the tissues and aging. The situation is that the adequate functioning of cells and tissues, adequate quantity of peptides required to maintain optimal operation mode of the genes. The peptides are active in different cells also synthesized in them. Therefore, the cell function is disrupted, with aging, thereby disrupted the reproduction of peptides, resulting in cellular functions suffer damage again. The degeneration of the tissues increases, which would ultimately mean clinical case. Therefore, the use of short peptides is one of the most important innovation in medicine and can significantly slow down the aging process, thanks to the implementation of regeneration and proliferation of the tissues and by increasing the number of cells. Another important advantage of the anti-tumor effect of the peptides. Currently, the use of peptides is the best no-compromise solution for the revitalization and prevention of cancer, because it allows the cells and tissues to renew, by coordination and regulation of cyclic processes, and division of the properly functioning new cells, without disorder.
11. Traditionally, the natural peptide bioregulators were present as injection, or capsules. Practice, we know that the short regulator peptides are not transformed in the digestive system, so anyone can use, since no side effects. The natural peptides exert their effects equally, whereas the feedbacks coming from direction of tissues, requires a certain amount of peptideformation to fund the deficit (homing effect). Just after this the cells begin to restore their normal operability "and thereby stopping the swinging, thus all processes detoured to the golden mean" (V. Kh. Khavinson, 2009). Using peptides for 2-4 month is giving an impact and protection for 4-6month. After this period, taking the peptides are recommended to start again.
12. VENFORT natural peptid capsules Peptide fractions complex extracted from young animal's blood vessels . The selected peptides are selective effect on different cells of the blood vessels, regenerate the vascular tissues, optimize the cellular metabolism and function of vessel’s tissues. Indication high blood pressure, cerebral blood vessels and cerebral circulatory disorders, cerebral arteriosclerosis, arteriosclerosis in limbs, varicose veins, hemorrhoids, coronary heart disease, angiopathies (large and small artery damage), endarteritis Usage: 1, up to 2 capsules/day with meal
13. SZIGUMIR natural peptid capsules Peptide fractions complex extracted from young animal’s cartilage and bone’s tissues. The selected peptides are selective effect on different cells of the cartilage and bone’s tissues, correct, regenerate and control the cartilage and bone’s cells, optimize the cellular metabolism and function of cartillage and bone’s tissues. Indication Spinal diseases, rheumatism, osteoporosis, arthritis, joint inflammation (arthritis), joint wear and inflammation, osteochondrosis Usage: 1, up to 2 capsules/day with meal
14. VLADONIX natural peptid capsules Peptide fractions complex extracted from young animal’s thymus. The selected peptides are selective effect on different cells of immune system, correct, regenerate and control the immune system’s cells, optimize the cellular metabolism and function of immun system’s tissues. Indication primary and secondary immunodeficiency (immunodeficiency), prevention and rehabilitation of tumor diseases, chronic poisoning, heart attack and stroke rehabilitation, post-operative rehabilitation, body rejuvenation programs Usage: 1, up to 2 capsules/day with meal
15. SZVETINORM natural peptid capsules Peptide fractions complex extracted from young animal’s liver. The selected peptides are selective effect on different cells of liver, correct, regenerate and control the liver’s cells, optimize the cellular metabolism and function of liver’s tissues. Indication correction of any metabolic disfunction of liver or bile, impaired liver function, any chronic hepatitis, poisoning, chronic poisoning, any skin diseases, jaundice, corrects the abnormal lipid metabolism, thus no cure for atherosclerosis, obesity, diabetes Usage: 1, up to 2 capsules/day with meal
16. CERLUTEN natural peptid capsules Peptide fractions complex extracted from young animal’s brain. The selected peptides are selective effect on any cells of brain and nervous system, correct, regenerate and control the brain and nervous system’s cells, optimize the cellular metabolism and function of brain and nervous system’s tissues. Recommendation: Prevention or treatment of any brain and nervous system illness, Cerluten normalizes the brain activity, and regulates its operation. Impaired memory and impaired concentration, cerebral arteriosclerosis, stroke, post-treatment, Alzheimer's and Parkinson, chronic fatigue syndrome, depression, neuralgia and neuritis Usage: 1, up to 2 capsules/day with meal
17. TIROGEN natural peptid capsules Peptide fractions complex extracted from young animal’s thyroid gland. The selected peptides are selective effect on any cells of thyroid gland, correct, regenerate and control the thyroid gland ’s cells, optimize the cellular metabolism and function of thyroid gland Prevention and treatment of any thyroid disease and resulting secondary diseases Metabolic disorders, metabolic disorders (hormonal problems, restore hormonecontrol), decreased or increased thyroid function (hypo-and hyperthyroidism), goiter, autoimmune inflammation of the thyroid gland. Usage: 1, up to 2 capsules/day with meal
18. SZUPREFORT natural peptid capsules Peptide fractions complex extracted from young animal’s pancreas. The selected peptides are selective effect on any cells of pancreas, correct, regenerate and control the pancreas’s cells, optimize the cellular metabolism and function of the pancreas Prevention and Treatment of any pancreatic disease Especially: pancreatic function disorder, chronic pancreatitis, pancreatic insufficiency, fat and carbohydrate metabolism normalization, diabetes, correction of digestive processes Usage: 1, up to 2 capsules/day with meal
19. The concept of synthetic peptides We can use the short synthetic peptides - because they are virtually complete analogue of the natural peptides. But they are simpler, because of the "sintetica" is not a counterpart of the whole bioregulator peptide, but only the counterpart of interconnection of peptide and a specific part of DNA. Such refinement allows a very short period of time to achieve an appreciable effect. However, since the "sintetica" works hard and very quick, sometimes the tissue can not restore itself in the same tempo, so the patient complains of unpleasant feelings in the target organs. This is a perfectly normal and temporary phenomenon.
20. The natural liquid peptides The situation becomes even more complicated when it's not just a group of synthetic peptides for internal use, but a synthetic complex, contains: external use peptides, active ingredients and transdermal transactors (intermediaries). Therefore, drawing on the experience of the scientists, end of 2008, the following challenge is waited for us: creating a newnaturalpeptidecomplexes, whichoperateasfastas the "sintetica", butwithoutsideeffects. As a result of Khavinson'swork, configurationsfromhighlypurifiedpeptidefractionshavebeencreated, thatcanpenetrate almost anyphysiologicalbarrierwithouthelp of intermediariesThuswasborn professor Khavinson'snewwork, the newgeneration: externaluse of naturalpeptidebioregulators Peptidein the newline'smotto: "Speed, efficiency, safety" The peptidecomplex (PK) should be rubbedto the venous part of the forearm, and has to be rubbeduntilitstotalabsorption. 7-15 min after the peptidesare linked to the dendriticcells, whichtransmitthemtothelymphnodes, wherethepeptidesare "absorbedintotheblood" and by the blood-streamgettothetargetorgans and tissues. Usage: Rub into the entire forearm until complete absorption.In the first 10 days increase the dose, continually, from 3 drop up to 8. Larger quantitiy is not required.Packaging: 10 ml, enough for 1 month.
21. PK-01 Cardiovascularsystem PeptideComplexfortreatment of Cardiovascular System. Forregeneration of the heart and vascularcells, preventionorcure of cardiovasculardiseases. the bone’scells, preventionortreatment of bonediseases. Especially recommendedagainstprematureaging of cardiovascularsystem’scell, arteriosclerosis, highbloodpressure, preventionorrehabilitationofheartattackor stroke, postinfarctrehabilitation and post-stroke disorders
22. PK -02 peripheral and centralnervoussystem PeptideComplexfortreatment of brain, peripheral and centralnervoussystem. Forregeneration of the brain, peripheral and centralnervoussystem’scells, preventionorcure of brainorneurogicaldiseases. Especially recommendedagainstprematureaging, of braincells and allperipheralandcentralnervoussystem’scells, sclerosis and cerebral stroke, strokerehabilitation, inflammatory and degenerativediseases of the nervoussystem
23. Pk-03 immunesystem PeptideComplexfortreatment of immunesystem. Forregeneration of the immunesystem’scells, preventionortreatment of immunedisorders, againstprematureagingofallcellsin the body, hence significantincreasing the life expectancy, immuneenhancement, correction of immunedisorders. PK-03 reachinginto the body finds, regenerates and rebuildsall the damagedtissues and restoretheirfunctions. Thusit has a veryimportantrolein tumor prevention.
24. PK-04 joints PeptideComplexfortreatment of jointdiseasesForregenerationof the joint’scells, preventionortreatment of jointdiseases. the bone’scells, preventionortreatment of bonediseases. Especially recommendedagainstprematureaging of joint’scells, arthrosis, arthritis (izületi gyulladás), osteochondrosis, reuma
25. PK-05 bones PeptideComplexfortreatment of bonediseasesForregenerationof the bone’scells, preventionortreatment of bonediseases. Especially recommendedagainstprematureaging of bone’scells, and incase of bonethinning (osteoporosis), fractures.
26. PK-06 Thyroidgland PeptideComplexfortreatment of thyroiddiseasesForregenerationof the thyroid’scells, preventionortreatment of thyroiddiseases. Especially recommendedagainstprematureaging of thyroid’scells, metabolic and hormonalproblems, goiter, goitre, underactiveoroveractivethyroid, Hashimoto'sthyroiditis, thyroidcyst, mastopathy
27. PK-07 Pancreas PeptideComplexfortreatment of pancreasdiseasesForregenerationof the pancreas’scells, preventionortreatment of pancreasdiseases. Especially recommendedagainstprematureaging of pancreas’scells, chronicpancreatitis, diabetes mellitus (diabetes), impairedglucosetolerance, diabetes, cardiovascularcomplications
28. PK-08 Liver and bile PeptideComplexfortreatment of liveror gall diseases. Forregeneration of the liver and gall’scells, preventionortreatment of liveror gall diseases. Especially recommendedagainstprematureaging of liver and gall’scells, metabolicabnormalities, obesity, involuntarymovements, cholecystitis (gallbladderinflammation), poisoning, chronicpoisoning (chemicals, drugs, alcohol), cirrhosis, chronicoracute hepatitis and otherliverdiseases.
29. PK-09 Male urogenitalsystem PeptideComplexfortreatment of malegenitalsystemdiseases. Forregeneration of the malegenitalsystem’scells, preventionortreatment of malegenitalsystemdiseases. Especially recommendedagainstprematureaging of malegenitalsystem’scells, chronicprostatitis, BPH (benignprostatedisease), infertility, erectiledysfunction, othersexualdisorders
30. PK-10 Femaleurogenitalsystem PeptideComplexfortreatment of femalegenitalsystemdiseases. Forregeneration of the femalegenitalsystem’scells, preventionortreatment of femalegenitalsystemdiseases. Especially recommendedagainstprematureaging of femalegenitalsystem’scells, chronicadnexitis (inflammation), menstrualfunction, menopause, decreasedlibido, infertility, fibroids, tubal, mastopathy (cysts)
31. PK-11 Kidney, urinaryorgans PeptideComplexfortreatment of kidney and urinaryorgandiseases. Forregeneration of the kidney and urinaryorgan ’s cells, preventionortreatment of kidney and urinaryorgandiseases. Especially recommendedagainstprematureaging of kidney and urinaryorgan ’s cells, chronicrenalinflammation, interstitialnephritis, glomerulonephritis (inflammation of the glomerularlesionsassociatedwithinflammation), kidneystones, chronicrenalfailure
32. PK-12 Lungs and respiratorysystem PeptideComplexfortreatment of lungsorrespiratorysystemdiseases. Forregeneration of the lungs and respiratorysystem’scells, preventionortreatment of lungsorrespiratorysystemdiseases. Especially recommendedagaintsprematureaging of lungs and respiratorysystem’scells, chronic bronchitis, pneumonia, emphysema, respiratoryallergies, asthma, otherrespiratorydiseases.
33. PK-13 Skin PeptideComplexfortreatment of skin and skindiseases. Forregeneration of skin’scells, preventionortreatmentofanyskindiseases. correction of skintone and structure, correction of anyskindefect. PK -013 rebuilds the skin'stissue, and makes a perfectskinstucture. Thusitreccommendedas a cosmetictreatmentaswell.
34. PK-14 Veins PeptideComplexfortreatment of veindiseases. Forregeneration of the vein’scells, preventionortreatment of veindiseases. Especially recommendedagainstprematureaging of vein’scells, thrombosis, varicoseveins, hemorrhoids, thrombophlebitis (deepveinthrombosis), venousthrombosisbecauseofulcer
36. mezotelforinternaluse The internaluseintendedliquid –based MEZOTEL productsbelongto the 1-inch classgeroprotectors (bioregulators). Mezotelsare a commonwork of Professor Khavinson and Professor Gorgiladzeimmunologist. ThisMesotelfamilycontainsrareingredients, whichstronglycontributetoslowing down the aging, stronglydetoxifythe body, effectivelyimprove the functioning of the nervous and immunesystems, enhance the physical and mental performance, and havestrongantioxidantandrevitalizationeffects
37. Mezotel The Mesotelcontains a series of basiccomponents, interalia the essentialingredienttotherevitalization, which is a precursortoacetylcholine, namedcholinebitartarat. Choline is the main activeingredient of Mesotelproducts. The components of MEZOTEL: cholinepeptides, the colloidalsilver, thegotucola and goji. Usage: 1 teaspoon per day, before or during a meal. Packaging: 120 ml, sufficient for one and a half months.
38. choline 1.Normalizes and stronglyincreases the energypotential of nervecells, therebyincreases the brainactivity. 2. Increases the memory and concentrationcapacity, enhances the cognitivefunctionsinthebrain 3. Increases the resistancetheoverload, stress, fatigueagainst 4. stronglyenhances the mental and physicalactivity 5. Slows the agingprocess Choline is involvedinmanyimportantbiologicalprocesses. As a phosphatidyl-cholinepreserves the integrity of the plasmamembrane, and basicphysiologicalfunctionsinvolvedinsuchastransfer of informationsbetwencells, energysupplyofcells, and intracellularcommunication. Inadequatecholineintake, mightaffecttheseprocesses. Choline is alsoinvolvedin the preservation of cellstructures and functionswell. It is noteworthy, thatcholinedeficiencyleadstoapoptosis (a form of celldeath) orprogrammedcelldeath. Indeed, if the cholinecontent of the membranebecomeslowerthenthenecessary, itincreasestheceramiderelease, and itseemsthat the accumulation of ceramideactivates an enzyme, named: caspasewhichinducesapoptosis.
39. Strong impact on cellular rejuvenation, strong wrinkle-smoothing effect, removing the discolouration. The pigment spotsaredigestionresidues of lysosomal (highfat) diet. Theseso-calledagingor,, wear "pigments, whichcan be foundon the skin, liver, kidney, myocardium, and adrenalganglia. The more pigment cause more fastagingprocess. Choline has the abilitytoremovelipofuscin(aging pigment) from the cells, whoseaccumulationacceleratestheagingprocess of body cells. sejt fiatalító Thissignificantlyaffects the body and cansignificantlyextend life. Already more than 35 years of research, which examined the effectiveness of the acetylcholine's predecessor, suggest, that restoring the intake of acetylcholine allows the increase in age of 20-25% . In addition, choline is an inhibitor of free radicals , so in the composition of the mezotel products we put colloidal silver, thus allowing multiply the antioxidant activity.
40. Silver colloid Destroysallpathogens. The silvercolloidpenetratesthroughthecellwall of pathogens (bacteria, fungi, viruses, parasites) inhibits the thiol-enzymesthatareinvolvedinthemetabolism of pathogens, and causetheirdestruction. Itcandamagecellstructure of pathogens, and makesthemincapable of reproduction. Colloidal Silver doesnotharm the intestinalflora of largeintestine, as the latestinthesmallintestine is absorption. The Science Digestmagazinereports (March 1978 figure) about the colloidalsilver test: Among the 650 differentkind of pathogenswerekilledwithinsixminutesin a micro-colloidalsilvertube. A regularsyntheticantibioticdeactivateonly 6-12 strains of bacteria
41. The colloidal silver is the most effective detoxifying substance Weuse the pure, naturalform of Colloidalsilverwhich is a systemthatcontainsa 100-500 millimikron sizedparticles. The colloidalsolution, incontrasttothesilversaltdoesnotaccumulateinthe body, and thereforecompletelyharmlessevenunderregularuseaswell. The colloidalsilverdoesnotinteractwith, and doesnotaffectothermedicines. 1. Colloidalsilver is the safest and most effectivenaturalantiseptic and detoxifying 2. The Colloidal Silver candestroy more than 650 types of germswithin 6 minutes 3. Destroys and inhibits the growth of bacteria, viruses, fungi, parasites.
42. The colloidal silver is almost good for everything A colloidalsilversolutioncan be usedvirtuallyforall of tInfection and inflammationon the body surface , and inside the body forhiddeninfections, inflammations.Itcan be usedforSorethroat, tongue, mouthInflammation and injury, gumproblems, cavities, nasalandrespiratoryInfections, influenza, pneumonia, earInfections, Inflammationeye, conjunctivitis, stomachulcers, intestinalproblems, and Candida Infection. The colloidalsilvercan be preventableinfungus of the feet, nails, nail, ear, armpit, thrush and other body parts. Whenitmassagedinto the head-skin, willhelptoeliminatedandruff and itching of the skin Reportedthatcolloidalsilvercan be effectivein HIV / AIDS, Lyme diseasecausedby őz kullancs, meningitis, lymphatic, arthritisaswell. In the case of hayfever and allergyquicklyeliminate the kind of coldsymptoms, and the itchingintheeye. Remedies the burns, cutwounds, scrapes. Itssunburn, acnetreatment is fantastic. Thereare no harmfulsideeffects of the high-qualitycolloidalsilver
43. Gotu kola The GotuKola, is one of the most powerfulrejuvenatingherb. While the yogiswasusedtomeditation, formakingtheirconcentrationbetter, gotucolaeffectivelyimprovingtherelatedeffectssuchasmentalretardation. Itsproved, thatgotucolacanincreaseeven the IQ level. The GotuKolabeenproventoincreaseintelligence, improvememory, eliminatesthephysicalfatigue, mentalfatigue and depression, andboosts the vitality, shakeuptheimmunesystem, therebysignificantlyincreasingthe life span. This is the Indianplant, ayurvedicmedicine, the most importanttooltoencourage and strengthen the functioning of nerve and braincells.
44. The gotu kola's effect on the skin The gotukolacontainstheverystrongtissue-regeneratingbiopolymers, thusit has multipliedrejuvenatingeffect One of the rareplants, whichcontain a significantquantity of collagen, soitcanstronglyimprove the condition of connectivetissueso and highlyincrease the skin'selasticityevenat old age. Notonlyin the connectivetissue, theskin is stillabletosignificantlystrengthen and regeneratetorepair the damagedtissues. This is duetoitsuniqueasiaticosidcontentthatdissolves the waxedcover of pathogens, allowing the immunesystemtodestroythem. Therebyeliminatingeven the chronic and intractableskindiseases, includingleprosy, syphilis, psoriasisandeczema, variousrashes, burns, wounds, scars, internalandexternalulcersandinflammations. A Frenchresearchin 1966 showedthatafter a cesareansection, the gotukola'sapplying is veryeffectiveinimproving the healingprocess. The woundhealedmuchfasterthanatconventionaltreatment. The hairloss, which is also a skindisease, ableto stop, and evenenhanceyourhairandnails 'strength'
45. Very strong detoxifyingeffect Gotu kola is a very strong blood purifier, helps to remove accumulated toxic substances from the brain, as well as heavy metals and a variety of drugs can help to remove from the body
46. goji Goji is a verypowerfulnaturalantioxidant. Strengthens the structure of the bloodvessels, improvesbloodcirculation, thuspreventingthrombosis. Promotesrecycling and increaseefficiency. Itcontains a hugeamount of activeingredients: polysaccharides, phenolicacids, vitamins (Bl, B2, C, E, carotene, riboflavin, nicotine), xanthines, leucine, phytosterol - daukosterin (sitosteril-β-β-D-glucoside), betaine, seizedfizalin , alkaloids, proteins, taurine, 19 aminoacids, minerals and traceelements (calcium, magnesium, iron, copper, manganese, zinc). Itsbeta-caroteneconcentration is higherthan the carrot's, and itscollagenand protein contenthigherthan the royaljelly's. Therefore, cangreatlystrengthen the immunesystem, slowtheagingprocess. Itactivate the serotonin, thusimprovesTherefore, cangreatlystrengthentheimmunesystem, slowtheagingprocess, serotoninactivation of itseffectsimprovesmood, helpswithsleep, relievesfatigue and provideshugeenergy Clinicalstudieshaveshownthat the gojistrengthensthecellwalls, whichcontributestotheirgrowth and theirregeneration.
47. Mezotel beauty The above-mentionedcomponents is (Kolin, colloidalsilver, Gotu Cola, Goji) has a highcontent of zinc. Usage: 1 teaspoon per day, before or during a meal.Packaging: 120 ml, sufficient for one and a half months.
48. Zink Ifthere is an element, which is reallyimportant, and realrejuvenating, thenthis is the zinc. The main hormonesinour body, the testosterone, thegrowthhormone, theinsulin and the growthfactor 1 (IGF-1) - donotworkwithoutit. Thesehormonesuse the zincastheir main enzymesource, thustheycanperform the most importantfunctions. A zincactivates 200 enzymes, and one of the most importantantioxidant. • Increases the body'sresistance • Spermproduction and testosteronesynthesis • Adequate vitamin metabolism • peptides, DNA and the regulation of celldivision • Itmayhelptocureinfertility. • Helpseliminateprostatecomplaints • Speedsup the healing of internal and externalwounds. • Removes the whitespotsfromthenails • Enhances the growth and mentalsharpness • Reducescholesteroldeposits • Contributesto the healingmentaldisorders.
49. Howdoeszincworks? The zincactsinthe body like a trafficcopMonitors and controls the metabolicprocesses of enzymesystems, maintains the integrity of the cells. It Is essentialfor protein synthesis, acid-basebalance, insulinsecretion, musclecontractileability, brain-operation ( experienced a positiveimpactinschizophrenia). Itrequiredfor DNA synthesis, woundhealing. Alcoholics and peoplewith diabetes need a higherdose of zinc. Zincdeficiencycancauseprostateenlargement, arteriosclerosis, whitestreakson the nails. Zinchelpsincase of infertility, prostatedisease, growthdisturbances, impotence, irregularmenstruation, senility. Zinkenhancesmentalsharpness, helpstotreatmentaldisorders. It has Importantrolein the development of reproductiveorgans. Zinc has the main roleinmetabolicprocesses, coordinate the functioning of certainenzymes, maintains the integrity of the cells. Essentialinadjusting the pH of the blood, thushelpsmaintainthebody'sinternalbalance. Itprovidessomeprotectionagainst the pollution of the environment, becausepreventingtheincorporation of lead and cadmiuminto the body. Accelerates the healing of internal and externalwounds.
50. Mezotel neo Nextto the choline, colloidalsilver, gotukola, gojicomponents, alsocontainslargeamounts of resveratrol. the today'sbest-knownlipid-regulator Usage: 1 teaspoon per day, before or during a meal.Packaging: 120 ml, sufficient for one and a half months
51. resveratrol The most importantproperties of resveratrol: 1. It is a powerfulantioxidant 2. Lowersbloodcholesterollevel 3. Preventsarteriosclerosis 4. Regulates and optimize fatmetabolism 5. It is beneficialto the skin, - stimulatescollagensynthesis 6. Improves the functions of the femalehormones 7. Reduces the risk of osteoporosis The resveratrol (trans-3, 5,4 '-trihydroxystilbene), is a substance, whichfoundin the redgrape'sshell. Itcameto the focus of scientific interest fewyearsago, as a possibleexplanation of the "French paradox" . ("French paradox" - what is the reasonforthelownumber of cardiovasculardiseasesin France, wherepeopleeathigh-fatfoods?) Todayit is seenas an effectiveantioxidant, phyto-estrogen, protectoragainstcancer and cardiovasculardiseases. It is proclaimedas "The French Paradox , which is enclosedinglass."
52. Cardiovasculareffects A lot of researchsuggeststhatalcoholconsumption (particularlyredwine) mayreducecoronaryheartdisease. Someresearchalsoshowedthatit is a powerfulantioxidant . Itpreventslow-densitylipoproteins (LDL, low-densitylipoprotein) peroxidation, and protects the cellsfromtheharmfuleffects of oxidized LDL, and protectsagainstlipidperoxidation. Sinceit has hydrophilic and lipophilicproperties, itcan be much more effectivethan the well-knownantioxidants vitamin E and C. It is alsoshowntoreduce the risk of accumulationofplatelets, soreducing the risk of atherosclerosis.
53. Impactoncancer Haveshownthat the resveratrol is a strongantioxidant , soitinhibits the formation of free radicals and it has anti-mutageniceffect. Itappearsthatresveratrolreduces the development of the tumor throughinhibition of cyclooxygenase-1 enzyme - an enzyme, whichconvertsarachidonicacidtoinflammatorysubstancesthatstimulate tumor growth. Someresearchsuggeststhatresveratrolcauses the differentiation of leukemiacells, and inhibits the enzymeribonucleotidereductase - thisenzymerequiredfor DNA synthesisinproliferatingcells.
54. Estrogeneffects The structuralsimilarity of resveratrol and diethyl-stilbestrol (a syntheticestrogen) was the reason of researchesabout the phytoestrogeneffect of resveratrol. (phytoestrogen is a herbalingredient, which has estrogen-likeeffects). Thesehormones link to the estrogenreceptorsoncells. The estrogen-receptorcomplexinteractswith DNA incertainsections, thusstimulatesestrogen-sensitivegenes. Incase a material is linked to the estrogenreceptors, and trigger a responsereactiononendogenousestrogens, thenthismaterial is estrogenagonist. Incase, a material is linked to the estrogenreceptors and prevents the endogenousestrogen-inducedresponses, thenthismaterial is estrogenestrogenisantiagonist. The chemicalstructure of resveratrol is verysimilarto a syntheticestrogenagonist, diethylstilbestrol, whichsuggeststhatresveratrolworksas an estrogenagonist
56. foodsupplements The number of peoplewithweakenedimmunesystem is increasingyearbyyear. The reasonforthis: pollution and malnutrition. The totalhealthstatisticsshowsthatit is timetochange the lifestyle and tobring a newvisioninmedicine. The most importantfactorinthisissue, is the personalapproach. Expertsbelievethat, the foodintake of a modern person, has tocontain more than 600 differentnutrients. Veryfewpeoplecansaythat, properlynourished, evenfewerthatarenotexposedtoharmfulpollution. Accordingly, number of the perfectlyhealthypeoplewithoptimal immun intensity, is verylow. So, here is the question: howtoreachtheidealbalance, sothatnotonlytoday and tomorrowwilltakecare of ourselves, butfor the whole of ouractive life?
57. Prevention of prematureaging Inresponse, ourcompany'sbiologicallyactivefoodsupplements, whichcreatedby St. Petersburg Institute immunologist Professor: Dr. Tsyganov. Thesesupplementsconstantlyhelptorestore the health . The komplex use of thesesupplements has one of the most importantfunction: toensure the prevention of prematureaging, topromote the normalization of metabolism, tostrengthenour body withoutsideeffects. One, maximum two capsules are enough for reaching positive effects
58. Cinsil-t Itsuitablefor: the prevention of prematureaging, immuneboosting, antioxidant status, tension, stress and insomnia. Stroke and brain-headinjuries. Allergies, skindiseases, carbohydrate and fatmetabolism, diabetes, arteriosclerosis, vasoneurosis, highbloodpressure. Besides a number of the mentionedcomponents, itconains: zinc, glycine, vitamin B6
59. ZINc Zinc is an essentialelemenetforhealthyfunctioning of the ourorganization'cells. It has importantroleinregulating the metabolicfunctions, regulatestheoperating of the main hormones, and more than 200 enzyme. Itsetsupourblood'sacid-basebalance. Zincpromotes protein synthesis, restoring a healthyweight. Similarly, the ascorbicacid, zinchindersthespread of viralinfections, promotes the formation of whitebloodcells, and retains the neutrofils, T-lymphocytes and ournaturalanticancercellsPromoteshealing of wounds, affectsmuscle and brainfunctions. Cures and prevents almost all of the skindiseaseZinc is abletocorrect the bloodsugarlevel. Thiselementhelps the pancreasproducetheenzymes, and protectsallcellmembraneswhichareresponsiblefor entering hormonoesto the cells.
60. glycine The glycinesignificantlyimprovetheprocessing of zinc and also has a range of excellentproperties. Abletoreduce the psychoemotionaltension, aggression, conflicttendency. Helpsinsocialadaptation, improvesyourmood, helpsnormalize the sleep, increasesmentalability, reducethealcohol- and drug-relateddisruption of the centralnervoussystem
61. Vitamin b6 The pyridoxine (vitamin B6) has manyimportantfunctions, but the most importantthing is, thatitprovides the aminoacidmetabolism. Inaddition, participatesin the exchange of neuromediatorssuchasserotonin and dopamine. Accordingtoneurophysiologist'sview, the peoplesufferingfromdepression, needslargerquantities of vitamin B6. The pyridoxine (B6) is involvedin the reproduction of redbloodcells and hemoglobins. The pyridoxineplaysimportantroleinthe protein-, fat-, and carbohydratemetabolism. Ithelpstodelivercarbohydratefrommuscle and liverto the blood. Thisprocess is veryimportantfor the billions of nervecellsin a continuoussupply of glucose. The pyridoxinedeficiencycausesreductioninthenumber of antibody, reducesbody-resistance.
62. Kalsil-T The Kalsil-Tcontainsnaturalcitrates, calcium and magnesiumcarbonate, A, D3, E vitamins. This is the most efficientway of the calciumabsorption. It'sbio-availability and absorption: upto 70%. (normally the calciumabsorption is only 2-8% ) It is recommendedfor the followingproblems: Prematureaging, nervoussystemproblems, cerebralinsufficiency, depression, insomnia, memoryloss, dizziness, tinnitus, increasedmental and physicalstress, eyediseases. Itcan be helpinheart and vasculardisorders, likeheadache, hypertensivedisease, coronaryheartdisease, bloodclottingdisorders. Kalsil-T is an effectivehelpinmusculo-skeletaldisorders, like osteoporosis, fractures, rheumatism, arthritis. Preventshormonalproblems, likegrowthslowdown, menopause, diabetes. Helpsinskindiseases and hepatitis aswell.
63. Calcium Inadditionto the specificproteins, thecalciumionsprovidetheskinfirmness and elasticity. Calcium is a major impacton the functioning of the nervoussystem, ensuringthebalancebetweencorticalexcitation and inhibitionprocesses. Calcium is involvedin the transmission of nerveimpulses and musclecontraction. Calciumprovides the muscletension and release. The organization'slack of calciumleadsto osteoporosis and fragility. An adult human bloodcontainsusually 2.25 to 2.75 mmol/ l calcium. Calciumdeficiencycausesinsomnia, nervousness, increasedheartrate, highbloodpressure. Itwasfoundthatagingcausesnotonly a decreasedcalciumabsorption, and D vitamin absorptionbutalso a decreased vitamin D productioninskinSincecalcium and vitamin D foundinfoodsaregenerally the same, sothatthecalcium-poorfoodsgenerallydoesnotcontainany vitamin D. There is one more aspect of organiccalcium: namely, the role of cancerprevention. The calmodulin (the regulator of cell protein) becomesactivebycalcium. The intra-andextra-cellularcalcium ratio, and the membranepermeability of calciumions is essentialforcelldivision
64. magnesium Magnesium as a coenzyme, involved in a number of important enzymatic process. The magnesium is the structural component of a wide range of enzymes (about 300), including the adenosinetriphosphate-dependent enzymes. Magnesium has cardioprotective effect in rhythm disturbances, coronary heart problems - including myocardial infarction, improves the myocardial oxygen supply, thereby limiting the injured area. Simultaneously, the vasodilator effect of magnesium is important and helps to decrease blood pressure. Magnesium as a stress release particulate, has normalization effect on the nervous system in case of nervous tension. Magnesium prevents vascular complications of diabetes, and improves the pancreatic beta-cell function. In case of respiratory system diseases, facilitates expansion of the bronchi and the passing of bronchospasm. In both cases, the magnesium is an important factor in prevention. Magnesium has a beneficial effect on the reproductive system as well. During the menopause to reduces the adverse effects.
65. imusil Imusilcurrently is one of the bestimmune-enhancingfoodsupplementinthe market. Strengthens the immunesystemprotectsagainstinfectiousdiseases and treatthem, eliminates the permanenteffects of pollution, treatingallergies and eliminates the permanenteffects of increasedantibioticintake. Applicabletochronicdiseases, gastrointestinaldiseases (obesity, metabolicdisorders, chronicstomach and intestinedisorders), heart, lungandliverdiseases, oncologicaldiseases, fatigue, stress, highphysicalexertionandintensive sport. The Imusil is completelyharmless, children and adultsalikecantake, becausesimilarlytoall of ourproducts, it has no sideeffects. Imusil is the key of long life, health, intellectual and physicalcondition
66. Howdoes the Imusilwork? The firstfewweeksafterbirthoccursinthegastrointestinaltract, thedevelopment of naturalmicroflora. A perfectlyhealthyadult human intestine is filledwithmanymillions of bacteriathatpromote the conduct of variousphysiologicalprocesses. The naturalbacteriahelpswithdigestionbybroking down the foodintocomponents, thusimprovingthe rapid absorption of usefulmaterials. Lacto- and bifidobacteriassynthesize vitamin K and C and somegroups of vitamin B, improvesabsorption, of vitamin D, iron, calcium and manyothercomponents. The lacto- and bifidobacteriasinvolvedin the mucosalrecoveryprocess. Incase of usefulbacteria'svolumedecreasing, the harmfulbacteriasmultiply and getactivated. Inthiscase the balance of intestinalbacteriasdisrupts, whichcausesdysbacteriosys. More than 50% of the world'spopulationsufferfromvaryingdegrees of dysbacteriosis.
67. More… The proliferation and excessiveconsumption of antibioticsledtoemergenceof more and more adaptable-mutatingviruses, bacteria and otherpathogens, arecause more infectiousdiseases. While the number of infectiousdiseases, viral, fungalinfections, allergies is increasing, at the sametime, thesignificance of preparationswhichsupportingnaturalmicroflora, is alsoincreasing. The so-calledprobioticsareincreasinglyusedinstead of a conventionalantibiotictreatments, and theirefficiency is no worse. One of the most effectiveprobioticproduct is the Imusil. Initscompositionfound the harmless, lacto-andbifidobacteriacomponents, whichmaintainoptimallivingspacefortheusefulmicroflorainthe human body. Inaddition, the product is enrichedwithnaturalimmun-modulators, suchas vitamin C and echinaceaextract. Accordingto the currentlevel of medicine,there is no analogue of thispreparation. inEastern Europe.
68. olekap Olekapeffectivelystrengthens the slowing of the agingprocess. Helpsespeciallyincardiovascularproblems - thrombosis, hypertensivedisease, coronarydisease - helpstopreventheartattacks and strokes. Giveseffectivesupportin the case of metabolicdisorders, likefatmetabolismproblems, diabetes, highcholesterol. Contributesgreatly the rehabilitationafterchemoradiotherapy. Ituseableincase of excessiveimmuneresponse and allergicreactions The Olekap's main componentsare: the Irishsalmonoil, redpalmoil, soybeanoil.
69. IRISH SALMON OIL WITH VITAMIN A AND E The salmonoilcomponents - suchasthehighlyconcentrated and irreplaceable Omega 3 fattyacid-, reducebloodcholesterollevels, prevent the development of atherosclerosis, build the cellwalls, reducethepain, hinderthedevelopment of chronicinflammations Red palmoil Practicallyall of tocopherolfoundinvegetableoil, however, the onlyonethatcontainsplenty of tocotrienols is the redpalmoil. The tocotrienolspromotescleansing of the bloodvessels, inhibitthrombosis, therebysignificantlyreducingtherisk of cardiovasculardisease. The pureredpalmoilusing is highlyefficientin diabetes, obesity, stomach and intestinalcomplaints, ulcer, highbloodpressure, angina, infarctus, skindiseases, boneinflammation, cataracts, and prevention of the throat, lungs - breast, bowel, and gastriccancerdevelopment. SOYBEAN OIL Amongall the vegetableoils, soybeanoil has the highestbiologicalactivity and 98% of itcanprocessedby the body. The soybeanoilcontainstheessentialpolyunsaturatedfattyacids (liketocopherol), whicharealsonaturalantioxidants. Itcontainsalsolecithin, whichregulates the cholesterollevels. The soybeanoilimprovesmetabolism, strengthenstheimmunesystem.
70. regenart The Regenartprotectsbone and cartilagesystem, encourages the creation of factorswhicharerequiredtorestoredamagedjoints. Itgives an effectivehelpintreatment of degenerativejoint and spinediseases, andreducesedemaandinflammation. It has liver-protectiveeffects and giveshelpatchronicpoisoning, chronic hepatitis, decreasedliverfunction. Itgiveseffectiveassistanceintreatment of neurologicalproblemssuchasbiliarydyskinesia (involuntarymovements), and inflammatorysymptoms, allergies The main components of Regenart: taraksacin, artichokes, dihydroquercetin, and chondroitinsulfate.
71. TARAKSACIN The dandelionextractcontainsmonoterpeneglycosid, namelytaraksacin. Taraksacin a doublefunctionin the human body. Impactson the internal fluid of joints, on the otherhandencouragesthecreation of cartilagerepairfactors. Itoccursbyspeedingup the metabolismprocesses of the liver. Inotherwords, the taraksacinprotects and restores the articularsurfaces. As a result, the cartilagebecomesclear again and regainitsself-reconstructionability.
72. artichoke The artichokeextract has stronghepatoprotectiveeffects, itscomponentsprotect the livercellsagainstpoisoning (eg, derivatives, alkaloids, salts of heavymetals, alcohol) . The artichokeextractincreasestheextraction of the coinzulinbyhepatocytes and effectsonlipids, cholesterol, ketonebodiesmetabolism, improvesliverdetoxificationfunction. The artichokeextract has a protectiveeffecton the bile. Increases the amount of extractedbile and facilitates the selection of bilesalt. Promotesdigestion, prevents the formation of gall bladderinflammation, reduces the gasproduction and regulatesbowelmovements. The artichokeextract has diureticeffect, reducebloodlevels of nitrogen-containingcompounds. The artichokeextractreducesbloodcholesterol.Usedintheprevention and treatment of atherosclerosis.
73. DIHYDROQUERCETIN The dihydroquercetinsignificantlyreducestheharmfuleffects of alcohol, reducesalcohol hangover feeling and the needforfurtherdoses, thusreducingthealcoholaddiction. Itsfeature, thatreduces the bloodlevel of high-densitylipoproteins, allows the use of arteriosclerosisaspreventive and curativepreparation. The increasedstability of the body tissuesagainstadverseeffectscausedbyhighbloodsugarlevels, is an opportunitytoreduce the probability of diabetes, and facilitate the medicine of itsdevelopedvariousforms. Sinceitcanreduce the harmfuleffects of variousexternaladversefactors (industrialcontamination, viralfactors, householdallergens, etc.), thususeableas an antiallergic and anti-inflammatorypreparation. The dihydroquercetin'sabilitytopreventtransformation of normalcells, intocancercells, aswellasslowing the spread of the cancercells, impliesexpectationsthatthismaterialcanreducethenumber of oncologicaldiseases
74. chondroitinsulfate Onereasonfor the destruction of the articularcartilage, is the chondroitinsulfatereductioninit. The chondroitinsulfate is the main structuralcomponent of cartilage. Inadditionit is involvedindeveloping of bone- and ligament tissues, and maintains the flexibility of bloodvessels. The chondroitinsulfate has one more interestingfeature: the chondroitininvolvedintheformation of urinecolloids and prevents the deposition of saltsin the urine, therebyinhibitingtheformation of urinarystones. A number of researchshowedthatchondroitinsulfate is notonlyprevents the destruction of articularcartilage, butencourages the reproduction of tissue. The chondroitinsulfate is usedtoimprove the movement of limbs, joints and spine, andreducespain.
76. PHYTO TEAS The exclusive, newestgeneration of ourteasbasedonayurveda and traditionalherbsandspices. The target is making a balancebetwen the variousprocesses. Weintroducenow, the uniqework of Professor Gorgiladze, who is an immunologist and scientist of the St. Petersburg Institute. He triedtoreplace the, tradicionalayurvedaherbs and spices, butinspirit, energy, andmicroparticlecomposition, closeto the original. However, thereare a manyuniqueplantin the easternmedicine, whichsimply has no equivalentinclassicalmedicine.Theseplantsare the main components of ourteas. Theseingredientspromote the self-regulationinthe body, self-cleaningprocess, strengthening the immunesystem and slowing down the agingprocess. One box contains 25 tea bag. One teabag is enough for two days
77. Agnimax – immunesystem and detoxification It has antioxidant and immunomodulatoryeffect. Accelerates the body's flow of energy and biochemicalprocesses. Promotes the burning of toxinsin the body and tissues.Encourages the recoveryprocess. Restores the digestivesystem.
78. Gelmax - immunesystem and detoxification It has strong, immunomodulatory and anti-parasiticeffect. Facilitates the removal of parasitesfrom the body, restores the gastro-intestinalsystem and the liverfunction. Encourages the detoxificationprocesses, reducesthebody'ssensitivitytoallergiescausedbyparasites.
79. Amiroton – immunesystem It has immunomodulatory. anti-inflammatory, and reparativeperceptibleeffect. Itrecommendedfor the followingdisorders: acut and chronicpoisoning, seriousillnessandpost-operativeperiods, chronicdiseases of gastro-intestinaltract, diseasesofrespiratory and urinarysystem
80. AKTOFORSZ – STRONG Detoxification Promotes the livermetabolism and liverdetoxificationfunctions. Normalizesfatmetabolism, and improves the vascularcellmetabolism., Promotesthemicrocirculationintheorgans and tissues. It has antioxidant and bloodpressureloweringeffect. Reduces the risk of developingatherosclerosis. Recommendedfor: vasoneurosis, hypertension, anytypes of atherosclerosis
81. Korgiton – cardiovascularsystem Helpsinregulation of vascularsystem, reducingpressureon the heartmuscle. Regulates the metabolism of heartmuscle and bloodvesselwalls. Itlowersbloodpressure. Itrecommendedfor the followingdisorders: vasoneurosis, atherosclerosis, 1 and 2 stage of hypertension, coronaryheartdisease. Promotestoreductionatincidence of heartattack and stroke.
82. ALVENORM – lung and respiratory organs It has immunomodulatory, analgesic and anti-inflammatoryeffect. Improves the functioning of the respiratoryorgans. Helpstocoughup the phlegm, and helpstoremovingsputum. Reduces the possibility of permanentdamageto the lungs. Stimulates the cellregenerationprocess of the bronchialepithelium. Recommendedforchronic bronchitis, emphysema, bronchialasthma, pneumonia
83. Dianorm – stomach and digestivetract It has perceptibleprotectiveeffectongastric and duodenalmucousmembrane. Promotes the extraction of gastric and pancreaticenzyme, improvesdigestion. Reduces the stomachpains. Itrecommendefor the followingdisorders: gastritis, duodenitis, gastric and duodenalulcers, chronicinflammation of pancreas.
84. Vedomix - digestivesystem Stimulates digestion, excretion, absorption, and the process of peristalsis. Balances the biochemical- and energy processes . Promotes the intestinal toxins burning. The Vedomix has antioxidant- and immunomodulatory effect. Encourages the process of tissue regeneration and slows the aging process. The Vedomix has weight-loss effect as well.
85. Defemax - COLON Promotes the bowelmovementsimproving. Reduces the level of venousslacknessinpelvis. Facilitatedefecationthrough the rectum and sphincter. Reduces the rate of developmentofvaricoseveins and hemorrhoids. Itrecommendedforconstipation and hemorrhoids.
86. Pangiton - pancreas Reduces the pressureonthepancreas and helps the tissuestoglucosedisposal. Reducesbloodsugarlevel. Reduces the development of diabetes and preventsfrom the development of angiopathyin diabetes. Regulates the production of insulin and digestiveenzymes. Accelerates the healingprocessinpancreasinflammation
87. Bilinorm - liver and bile Improves the liverdetoxification, restoresforming protein processesin the liver. Reduces the level of poisoning, alleviates "heavy" feeling in the upper right quarter. It has mildanti-inflammatory, antispasmodic and biletreatmenteffect. Slows down the liverfatformation and cirrhosis. Itrecommendedfor: hepatitis, biliarydyskinesia, chroniccholecystitis, postcholecystectomicalsyndrome, and chronictoxicity
88. Flonorm – kidney and urinary organs Promotes the normalfunctioning of the urinaryprocesses. It has diuretic, antispasmodic and anti-inflammatoryeffect. Restores the physical and chemicalproperties of urine, byreleasingsalt. Recommendedfor the followingdisorders: chronickidneyinflammation, stone, kidneycystdiseases
89. Refronorm – female urogenital system The Refronorm has antispasmodic, analgesic, and vascular-astringenteffect. Promotesnormalfunctioning of the femaleurogenitalsystem. Regulates the hormonalprocesses and emotionalbalance. Reduces the menstrualbleeding and pain. Facilitates the healing of menopausal hot flashes. Recommendedfor the followingdisorders: chronicinflammation of the fallopiantubes and ovaries, menstruationdisorders, premenstrualsyndrome, breastinflammation, menopause (climax)
90. Testonorm – male urogenital system Regulates the maleurogenitalsystem. Releases the congestionsintheprostate and pelvis. Improves the metabolisminprostatecells. Strengthenslibido and increasesbloodsaturationlevel of the malesexualorgan. Increases the sexualpleasure.Recommendedforthefollowingdisorders: chronicprostatitis, erectiledysfunction and earlyonsetprostatecancer.
91. Hodromix-locomotionsystem Stimulates the liverfunctioning. Promotes the formation of cartilageregenerationprocesses. Promotes the cellmetabolisminthejoints, reducespainsyndrome and swellingcausedbyboneinflammationorbonewear. Recommendedforosteochondrosis and anyrheumaticdiseases
92. Relanorm-nervoussystem Normalizes the nervous and digestivesystem. Increase the level of sensitivityof the nervoussystem, thusstimulatesthedefensivecapacityagainstvariousexternalfactors, likestress. Increases the stabilityagainstthephysical and psycho-emotionalpressure. Balances the attenuative and stimulatingprocesses of the nervoussystem. Restores the cyclicality of sleep and wakefulness. Makesiteasiertosleep, and makesitsmooth, balancedanddeep.
93. NASTRONORM – Mental Health The Nastronorm has sedative,and anti-stresseffect. Increaseshappiness and self-confidence. Recommendedforphysical and psychicoverload, prolongedstress, highirritability, mentalillness, neurosis, depressionandsleepdisorders.
94. The variousflavours of teas, promoteoptimaldigestion and metabolism. The teasreducetheabsorption of fatin the intestines, improvebowelmovements, and detoxify the body. Theirlaxativeeffect is mild. Theynormalize the microfloracomposition and correct body weight. Taste and chooseaccordingtoyourtaste A különféle ízesítésű fitoteák elősegítik az optimális anyagcserét és emésztést. Csökkentik a zsír felszívódását a bélrendszerben, javítják a bélmozgást, salaktalitanak és méregtelenítenek. Enyhe hashajtóhatásuk van. Normalizálják a bél mikroflóra összetételét és korrigálják a test súlyát. Kóstolja meg és válasszon ízlése szerint áfonya, meggy, szamóca, citrom, ananász ízesítésű teáinkból. AYURVEDIC TEAS IN SEVERAL FLAVOURS
97. PK-13 Skin PeptideComplexfortreatment of skin and skindiseases. Forregeneration of skin’scells, preventionortreatmentofanyskindiseases. correction of skintone and structure, correction of anyskindefect. PK -013 rebuilds the skin'stissue, and makes a perfectskinstucture. Thusitreccommendedas a cosmetictreatmentaswell.
99. REVILINE PEPTID NANOTECH CELL COMETICS A The NCPRIZ presents a unique REVILINE peptidbasedcellularcosmeticsfamily, which is a jointproduction of he company, the St. Petersburg Institute forGerontology and Bioregulatory Dr. Khavinson- and "Vita" Chemical-BiologicalAssociation. The REVILINE is a HighTechproduct. Itscompositonbasedondifferentpeptidcomplexgroups, whichtriggervisible and invisiblerejuvenatingeffect. The peptidecomplexesareusedtostimulateskincellregeneration, totransformunhealthyskintissueintoflawlessskintissue, ,toremovewrinkles, to optimize the metabolism and microcirculation, tohelp the synthesis of collagen and elastinThis is occursin the improvement of the skin'selasticity, structure, color and moisture
100. COMPONENTS In the REVILINE compositioncan be found the complexesareverystrongnaturalantioxidant (superoxidDismutas) and theirbiotechnology-derivedindicators. Thesecomplexeshaveantioxidant, immunomodulatory, UV protector, anti-tumoreffect, significantlyspeedup the detoxificationprocesses and the regeneration of skincells. The combination of naturalpeptides, and the superoxidedismutase - is a newphenomenonincellularrevitalization and cosmetics. Packaging: 55 ml, enoughforonemonth
101. Perfectskin, silkyhair and strongnails The peptidecomplexes, whichareseamlesslyabletopenetrateintothecells and penetratinginto the skincellsquicklybegintorebuildskintissue, triggerstrongrejuvenatingeffects, and produce a flexible, and perfectstructure of skintissue. Withinonemonth the changecan be achievedveryimpressive and spectacular. The otherveryeffectiveingredientsdetoxify, nourish, moisturize, eventhedeeperskinlayers. uNIMITABLE…
102. RL-01 Rejuvenation FOOTCREAM AGAINST varicose veins Rebuilds the skin's structure, flexibility, optimizes the microcirculation andmetabolism inthe skin, reduces swelling and pain in the legs, remove the varicose veins COMPOSITION: PK-3 and A-4 peptidecomplexes, a bioantioxidantcomplex, Neovitin ®, purifiedwater, castoroil, emulsifyingwax, glycerin, witchhazelextract, horsechestnutextract, Methylparaben, propilparaben, urea, mint USAGE: Aplly a creamwithenergetic, massagemotionsto the the problematic parts of the body. Use twice daily for two weeks, and then the next two weeks once a day
103. RL-02 REVILINE PEPTID - general anti-wrinkle facecream Strongly reduces the depth of wrinkles, rebuilds the skin's structure and makes it flexible. Removes the paleness, makes your complexion beautiful. Optimize the metabolism, micro-circulation in the skin and significantly slows skin aging process. Highly moisturizes, smoothes and rejuvenates your face. Reduces puffiness COMPOSITION: A-4 peptidecomplex, purifiedwater, jojoba, and oliveoil, Neovitin ®, tallow, wax, emulsifiers, urea, chamomile, sweetalmondextract USIGE: Apply a small amount of cream to clean skin and rub with massage motions until entire absorption
104. RL-03 REVILINE PEPTID ANTI AGING Night Cream Strongly reduces the depth of wrinkles, rebuilds the skin's structure and makes it flexible. Removes the paleness, makes your complexion beautiful. Optimize the metabolism, micro-circulation in the skin and significantly slows skin aging process. Highly moisturizes, smoothes and rejuvenates your face. Reduces puffiness COMPOSITION: complexpeptide A-6, bioflavolipidAktivitin ® complex, purifiedwater, glycerin, oliveoil, castoroil, Ceredin, beeswax, methyl, propyl, imidazolidinylurea, hydrolyzedcollagen, vitamin E USIGE: Apply a small amount of cream to clean skin and rub with massage motions until entire absorption
105. RL-04 REVILINE PEPTID ANTI AGING daytimefacecream Strongly reduces the depth of wrinkles, rebuilds the skin's structure and makes it flexible. Removes the paleness, makes your complexion beautiful. Optimize the metabolism, micro-circulation in the skin and significantly slows skin aging process. Highly moisturizes, smoothes and rejuvenates your face. Removes waste products and toxins, reduces puffiness and restores age-related changes in the skin. COMPOSITION: complexpeptide A-6, oliveoil and soybeanoil, bioantioksidantnyNeovitin ® complex, purifiedwater, glycerin, tallow, waxemulsion, urea, cocoabutter, gidralizovannycollagen, panthenol, vitamin E USAGE: Aplly a creamwithenergetic, massagemotionsto the the problematic parts of the body. Use twice daily for two weeks, and then the next two weeks once a day
106. RL-05 REVILINE PEPTID PURE SKIN facecreamwithgrapeseed oil Removes capillary dilatations, rosaceas from your face and neck. Reduces puffiness and dark circles around the eyes, strongly reduces the depth of wrinkles. Rebuilds the skin's structure, optimize the microcirculation and metabolism in the skin, strongly slows the skin aging. Highly moisturizes, nourishes, smooths and rejuvenates the skin, removes paleness, and makes your complexion beautiful COMPOSITION: complexpeptide A-3, licoriceroot, barkBetulavit ®, purifiedwater, glycerin, witchhazelextract, grapeseedoil, emulsifyingwax, urea USAGE: Aplly a creamwithenergetic, massagemotionsto the the problematic parts of the body. Use twice daily for two weeks, and then the next two weeks once a day
107. RL-06 REVILINE PEPTID anti agingBody Rejuvenation Rejuvenatinglotion, which rebuilds the skin's structure, strongly reduces the aging process, helps burn fat, tightens the skin. Optimize the microcirculation and metabolism in the skin, highly moisturizes, nourishes, rejuvenates and smooths your skin COMPOSITION: complexpeptide A-6, kaprilil, bioantioksidantnyNeovitin ® complex, purifiedwater, cocoabutter, oliveoil, glycerine, emulsifyingwax, urea USAGE: Aplly a creamwithenergetic, massagemotionsto the the problematic parts of the body. Use twice daily for two weeks, and then the next two weeks once a day
108. RL-07 REVILINE PEPTID Face cream for oily, acne-prone skin Rebuilds the skin's structure, strongly reduces the depth of wrinkles. Optimize the microcirculation and metabolism in the skin, strongly slows the skin aging, highly moisturizes, nourishes, smooths and rejuvenates your face, removes the paleness, and makes your complexion beautiful COMPOSITION: complexpeptide A-6, birchbarkextractBetulavit ®, purifiedwater, sageextract, chamomile and marigold, seabuckthornoil, waxemulsion, urea USAGE: Aplly a creamwithenergetic, massagemotionsto the the problematic parts of the body. Use twice daily for two weeks, and then the next two weeks once a day
109. RL-08 REVILINE PEPTID ANTI CELLULITE BODY LOTION Removes cellulite and helps to burn fat, detoxifies, rebuilds skin structure, and restores the skin elasticity. Optimize the microcirculation and metabolism in the skin, strongly slows the skin aging, highly moisturizes, nourishes, smooths and rejuvenates the skin COMPOSITION: peptidecomplex A-7, oliveoil, complexbioantioksidantnyNeovitin ®, purifiedwater, naturalcaffeine, soyoil, glycerin, tallow, waxemulsion, cayenne borskivonat, urea, cocoabutter, Fucusextract, copolymer, natrium USAGE: Aplly a creamwithenergetic, massagemotionsto the the problematic parts of the body. Use twice daily for two weeks, and then the next two weeks once a day
110. RL-09 REVILINE PEPTID ANTI-AGING body Lotion against scars, pregnancy strips, stretch marks Removes cellulite, pregnancy strips, scars, stretch marks and all kind of skin defects. Detoxifies. Promotes fat burning. Rebuilds the structure of the skin and restores its firmness and flexibility. Optimizes the microcirculation and metabolism in the skin, strongly slows the skin aging, highly moisturizes, nourishes, smooths and rejuvenates the skin COMPOSITION: peptidecomplex A-4, oliveoil, bioantioxidánsNeovitin ® complex, purifiedwater, soybeanoil, glycerin, stearin, waxemulsion, pumpkinextract, urea, cocoabutter, inulinlauryl USAGE: Aplly a creamwithenergetic, massagemotionsto the the problematic parts of the body. Use twice daily for two weeks, and then the next two weeks once a day
111. mezotel products FOR EXTERNAL USE The 3 external use intended, liquid-basedMezotel products, are intended for corrective therapy of the face and neck, the whole body, hair and scalp. Effectiveness of these treatments is so high, because the active ingredients are fully absorbed, able to penetrate into the deeper layers of skin, and start up regenerating processes This product (having regard to the their composition, action mode, effect) is much more relevant and more expedient as themesotherapy treatment. The difference is spectacular and eye-catching already after the first treatment.
112. Turningpoint in Cosmetics The traditional anti-aging cosmetics's basic component deanol (TNRE), we changed to a more effective component, which was completed with Neovitol, in order to enhance effectiveness. The NRE-4, is a double deanol molecule, a highly efficient multifunctional compound, which is four times more effective than the original one. This substance is not toxic, does not cause allergies or sensitivity, can be safely used around the eyes. The NRE-4 and Neovitintogether,has complex rejuvenating effect on skin. Corrects the imperfections, smooths out wrinkles, restores skin moisture, skin tissue, cell metabolism, microcirculation. Stimulates collagen, elastin and fibroblast production. (These three components are the main components of connective tissue which responsible for skin elasticity.
113. Skin impedance The preparation’s effects enhances the processes such as skin impedance. Skin impedance: The bodies mutually exchange electrical impulses to regulate and synchronize their operations for optimal effectiveness. The skin is an organ that is connected to all other organs and is involved in temperature regulation. The electrical impedance measures the effectiveness of nerve-information sharing, and electrical activity of this neural network
114. MezotelForface and neck Strongly reduces the depth of wrinkles, rebuilds the skin's structure. Stimulates collagen, elastin and fibroblast production, thus restores skin elasticity. Restores the skin's moisture content, effectively hydrates, smooths, and rejuvenates the facial skin, neck. Optimize the microcirculation and cell metabolism in the skin. USAGE: Apply to clean skin 2-3 ml mezotel and and rub with massage motions until entire absorption. Apply daily for 3 months. PACKAGING 50ml, enough for a month and a half
115. Mezotel body Corrects the imperfections, rebuilds the skin's structure. Stimulates collagen, elastin and fibroblast production, thus restores skin elasticity. Restores the skin's moisture content, effectively hydrates, smooths, rejuvenates the skin. Optimize the microcirculation and cell metabolism. USAGE: Apply 4-6ml mezotel and rub with massage motions until entire absorption. Apply daily for 3 months. PACKAGING 50ml, enough for a month and a half
116. MezotelForhair and scalp Optimizes the microcirculation and cell metabolism, restores moisture balance. Rebuilding the scalp structure, thus provides optimum conditions for hair growth. Prevents dandruff, strengthens hair follicles and prevents premature graying and hair loss, stimulates hair growth. Strengthens the hair structure, flexibility. USAGE: Apply the mezotel with energetic massage motions to the scalp and leave on for 30 minutes. PACKAGING: 50ml, enough for a month and a half
117. Contact us Mr. A Tomkus Email. vip@postbox.lt tusveikas@gmail.com