SARS-COV-2 detection by RNAscope technologyCOSMO BIO
Intense efforts are underway to develop vaccines for SARS-CoV-2. Many focus on the spike protein, which helps the virus infiltrate cells by binding the ACE2 receptor. Alternative strategies could block this receptor to prevent viral entry. Studies found SARS-CoV-2 uses ACE2 and TMPRSS2 for entry, and may use CD147 as an additional receptor. RNAscope probes target viral RNA to detect replication and localization in tissues, and can identify ACE2, TMPRSS2, and immune cell markers in infected samples.
SARS-COV-2 detection by RNAscope technologyCOSMO BIO
Intense efforts are underway to develop vaccines for SARS-CoV-2. Many focus on the spike protein, which helps the virus infiltrate cells by binding the ACE2 receptor. Alternative strategies could block this receptor to prevent viral entry. Studies found SARS-CoV-2 uses ACE2 and TMPRSS2 for entry, and may use CD147 as an additional receptor. RNAscope probes target viral RNA to detect replication and localization in tissues, and can identify ACE2, TMPRSS2, and immune cell markers in infected samples.
4. 作用点公知 細胞増殖抑制 生物活性未知
作用機構研究ツール
アッセイコンセプト確認
陽性化合物
創薬リード化合物 / 構造展開
用途特許出願
など、幅広い利用法
18.4 29.7 51.9
酵素阻害
膜蛋白質(受容体・
チャネル)
複製・転写・翻訳
シグナル伝達
細胞骨格・細胞周期
その他(RedOx)
30.0
25.0
20.0
15.0
10.0
5.0
0.0
100
-200
200
-300300
-400400
-500500
-600
600
-700
800
-900
1,000
-1,100
900
-1,000
700
-800
1,100
-1,200
1,200
-1,300
1,300
-1,400
1,400
-1,500>
1,500
O
O
H
H
O
OH
O
O
OH
O
H
H
OO
N
O
H
N
O
H
O
O
H
H
N
N
Br
Cl
O
O
O
O
O
Cl
Br
O
14. Catalog No. : T6234701-1
Cores : 90
Sixe : 2mm
Cut : 8μm
Format : 5×9
QA/QC : H&E
Slide 1
Slide 2
A
B
C
D
E
1 2 3 4 5 6 7 8 9
A
B
C
D
E
1 2 3 4 5 6 7 8 9
28. Cas9
sgRNA
TUNR
AAAAAAAAA
Your Gene of Interest
TUNR Gene of Interest
Introduction of the TUNR polyA track results
in reduced gene expression.
Wild Type
Short PolyA
Long PolyA
ProteinExpressionHighLow