The safety of Nimesulide has been reported before as well. In conclusion, Nimesulide has better antipyretic effect in children in the doses used in the study and appears to be safe for use in them.

1. Nimesulide for treatment of Fever
Nimesulide is a non-steroidal anti-inflammatory (NSAID) drug which has been found
to be useful in the treatment of fever.
A double-blind, crossover clinical trial was carried out in subjects with fever, to
assess the activity of three antipyretic drugs. Eighteen in-patients with body
temperature (axillary) above 38 degrees C were given a single dose of nimesulide
100 mg, acetylsalicylic acid 500 mg, and dipyrone 500 mg, orally according to an
incomplete balanced block design. Significant improvement was recorded with
nimesulide and dipyrone, which gave similar results. Acetylsalicylic acid normalized
body temperature in a few patients. Safety was very satisfactory. No local or
systemic side-effects were noted.
Clinical studies of Nimesulide in treating children with fever have been carried out.
In the children receiving Nimesulide, it took 8.6h to reach normal temperature. The
mean decrease in temperature for each cycle was slightly higher for the Nimesulide
group. The drugs were well tolerated by the children.
No side effects were reported in any child.
Nimesulide acted more rapidly in bringing down the temperature to normal.
Nimesulide appears to exert its effects also through a variety of other mechanisms
and involves interference with the production action of mediators other than
prostaglandins such as enzymes, toxic oxygen derivatives, cytokines, platelet
activating factor and histamine.
The safety of Nimesulide has been reported before as well. In conclusion,
Nimesulide has better antipyretic effect in children in the doses used in the study
and appears to be safe for use in them.