Mano y Corazón is an innovative, interprofessional conference organized by a Texas State Senator to bring together various health care professionals. It aims to enhance interactions between professionals from different institutions, including private hospitals, safety net hospitals, academic institutions, and public health. Over multiple annual conferences and sessions, it has addressed topics like ACOs, human trafficking, and community resiliency through practitioner-driven content. The conferences have no references to institutional titles, include research from different disciplines, and provide opportunities for unstructured interaction to help transcend barriers between professionals.