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![Omega-3 Status and US Military Suicide Deaths
Suicide Deaths of Active-Duty US Military and
Omega-3 Fatty-Acid Status: A Case-Control Comparison
Michael D. Lewis, MD; Joseph R. Hibbeln, MD; Jeremiah E. Johnson, RD;
Yu Hong Lin, PhD; Duk Y. Hyun, BS; and James D. Loewke, BS
ABSTRACT
Background: The recent escalation of US military
S uicide rates among active-duty US military have increased to re-
cord numbers, doubling since the inception of Operation Enduring
Freedom (Afghanistan) and Operation Iraqi Freedom and rivaling the
suicide deaths to record numbers has been battlefield in toll on the US military.1 Army Vice–Chief of Staff General
a sentinel for impaired force efficacy and has Peter W. Chiarelli described the record suicide rate as “horrible” and
accelerated the search for reversible risk factors. voiced frustration that “the Army has not yet been able to identify any
Objective: To determine whether deficiencies causal links among the suicide cases.”2(pA2)
of neuroactive, highly unsaturated omega-3 Deficiencies of nutrients critical for brain function may be a signifi-
essential fatty acids (n-3 HUFAs), in particular
docosahexaenoic acid (DHA), are associated with
cant contributing risk factor for psychiatric pathology, especially suicide
increased risk of suicide death among a large and stress-related psychiatric symptoms.3 Highly unsaturated omega-3
random sample of active-duty US military. essential fatty acids (n-3 HUFAs), in particular docosahexaenoic acid
Method: In this retrospective case-control (DHA), are selectively concentrated in neural tissues and are required
study, serum fatty acids were quantified as for optimal neural function.4 These fatty acids cannot be made de novo
a percentage of total fatty acids among US but are available only from dietary sources, with seafood being the richest
military suicide deaths (n = 800) and controls source. Nutritional deficiencies in n-3 HUFAs may increase vulnerabil-
(n = 800) matched for age, date of collection of
sera, sex, rank, and year of incident. Participants
ity to combat deployment stress, manifesting as psychiatric symptoms
were active-duty US military personnel including adjustment disorders, major depression, impulsive violence,
(2002–2008). For cases, age at death ranged and suicide.5 In civilian populations, observational studies indicate that
from 17–59 years (mean = 27.3 years, SD = 7.3 low fish consumption is associated with increased risk of completed sui-
years). Outcome measures included death by cides6,7 and greater suicidal ideation.8 Low DHA status was associated
suicide, postdeployment health assessment
questionnaire (Department of Defense Form
with increased risk of past suicide attempts9 and future suicide attempts.10
2796), and ICD-9 mental health diagnosis data. In comparison to placebo, 2 grams per day of n-3 HUFA reduced suicidal
Results: Risk of suicide death was 14% higher per
thinking and depressive symptoms and reduced the perception of stress
SD of lower DHA percentage (OR = 1.14; 95% CI, among subjects (n = 49) with deliberate self-harm.11
1.02–1.27; P < .03) in adjusted logistic regressions. These findings suggest that low DHA levels may be a contributing
Among men, risk of suicide death was 62% factor for adverse psychiatric symptoms. In this study, we posited that
greater with low serum DHA status (adjusted low DHA status would be associated with increased risk of suicide death
OR = 1.62; 95% CI, 1.12–2.34; P < .01, comparing
DHA below 1.75% [n = 1,389] to DHA of 1.75%
among military personnel. Prospectively collected serum and supporting
and above [n = 141]). Risk of suicide death was data were available from the Armed Forces Health Surveillance Center
52% greater in those who reported having seen (AFHSC) for a large number of active-duty suicide deaths (n = 800) and](https://image.slidesharecdn.com/seitzsimplesolutionstoperplexingproblemsmarch2012-120320051052-phpapp02/85/New-Jersey-simple-solutions-to-perplexing-problems-march-2012-97-320.jpg)
![Schizophrenia Bulletin vol. 35 no. 3 pp. 582–595, 2009
doi:10.1093/schbul/sbp023
Advance Access publication on April 8, 2009
Hedelin et al. BMC Psychiatry 2010, 10:38
http://www.biomedcentral.com/1471-244X/10/38
Schizophrenia Bulletin Advance Access published September 10, 2010 Relation of Schizophrenia Prevalence to Latitude, Climate, Fish Consumption, Infant
Schizophrenia Bulletin
doi:10.1093/schbul/sbq101
Mortality, and Skin Color: A Role for Prenatal Vitamin D Deficiency and Infections?
RESEARCH ARTICLE Open Access
ENVIRONMENT AND SCHIZOPHRENIA
Dietary intake of fish, omega-3, omega-6
Research article
Developmental Vitamin D Deficiency and Risk of Schizophrenia: A 10-Year Update
polyunsaturated fatty acids and vitamin D and the Dennis K. Kinney1–3, Pamela Teixeira2, Diane Hsu2, Siena derlie variations in schizophrenia prevalence deserves high
prevalence of psychotic-like symptoms in a cohort C. Napoleon2,4, David J. Crowley2, Andrea Miller2, priority.
William Hyman2, and Emerald Huang2
of 33 000 women from the general population x
John J. McGrath*,1,2,3, Thomas H. Burne1,2, Francois Feron4, Allan Mackay-Sim5, and Darryl W. Eyles1,2
´
2 Key words: epidemiology/etiology/immune function/
1
Queensland Center for Mental Health Research, The Park Center for Mental Health, Wacol, Queensland 4076, Australia; 2Queensland Genetics Laboratory, McLean Hospital, Belmont, MA; 3De-
Maria Hedelin*1,2, Marie Löf3, Marita Olsson3,4, Tommy Lewander1, Björn Nilsson1, Christina M Hultman1,3 and Brain Institute, University of Queensland, St Lucia, Queensland 4076 Australia; 3Department of Psychiatry, University of Queensland, St
partment of Psychiatry, Harvard Medical School, Boston, MA; prenatal/geography/risk factor
Lucia, Queensland 4076 Australia; 4Neurobiologie des Interactions Cellulaires et Neurophysiopathologie (CNRS UMR 6184), Universite de ´
Downloaded from http://schizophreniabulletin.oxfordjournals.org/ by guest on February 10, 2012
Elisabete Weiderpass2,3,5 ´ ´ ´ ´ ´ ´
la Mediterranee (Aix-Marseille II), Faculte de Medecine Nord, Institut Federatif de Recherche Jean Roche (IFR11), Marseille, France;
4
Wellesley College, Wellesley, MA
5
National Center for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland
Downloaded from schizophreniabulletin.oxfordjournals.org at UQ Library on September 19, 2010
4111, Australia
*To whom correspondence should be addressed; tel: þ61-7-3346-6372, fax: þ61-7-3271-8698, e-mail: john_mcgrath@qcmhr.uq.edu.au
Abstract Previous surveys found a large (>10-fold) variation in Introduction
Background: Low intake of fish, polyunsaturated fatty acids (PUFA) and vitamin D deficiency has been suggested to
play a role in the development of schizophrenia. Our aim was to evaluate the association between the intake of schizophrenia prevalence at different geographic sites Schizophrenia is an unusually burdensome disorder be-
different fish species, PUFA and vitamin D and the prevalence of psychotic-like symptoms in a population-based study There is an urgent need to generate and test candidate risk dations for future research. Key features of the evidence
factors that may explain gradients in the incidence of are summarized in table 1.
and a tendency for prevalence to increase with latitude. cause of the great economic costs of extensive care and
among Swedish women.
Methods: Dietary intake was estimated using a food frequency questionnaire among 33 623 women aged 30-49 years
schizophrenia. Based on clues from epidemiology, we pro- We conducted meta-analyses of prevalence studies to inves- loss of economic productivity, as well as the personal suf-
at enrolment (1991/92). Information on psychotic-like symptoms was derived from a follow-up questionnaire in the posed that developmental vitamin D deficiency may con- tigate whether these findings pointed to underlying etiologic
years 2002/03. Participants were classified into three predefined levels: low, middle and high frequency of symptoms. tribute to the risk of developing schizophrenia. This Vitamin D—The Basics fering and stigma, which often affect a patient and his or
The association between diet and psychotic-like symptoms was summarized in terms of relative risks (RR) and hypothesis may explain diverse epidemiological findings in- factors in schizophrenia or were the result of methodolog- her family for most of the patient’s life. Moreover, for
Ultra Violet B (UVB) radiation on the epidermis converts
corresponding 95% confidence intervals and was evaluated by energy-adjusted multinomial logistic regression. cluding season of birth, the latitude gradients in incidence
a cholesterol metabolite to vitamin D3 (cholecalciferol; ical artifacts or the confounding of sites’ latitude with level most patients there is still no cure or even an effective
Results: 18 411 women were classified as having a low level of psychotic-like symptoms, 14 395 as middle and 817 as and prevalence, the increased risk in dark-skinned migrants
to certain countries, and the urban-rural gradient. Animal a preprohormone). This is subsequently hydroxylated of healthcare at those sites. We found that these patterns way of treating many of the most disabling, ‘‘negative’’
having a high level. The risk of high level symptoms was 53% (95% CI, 30-69%) lower among women who ate fish 3-4 to 25-hydroxyvitamin D3 (25OHD), a prehormone com-
times per week compared to women who never ate fish. The risk was also lower for women with a high intake of experiments demonstrate that transient prenatal hypovita-
monly used to measure vitamin D status. A second hy-
were still present after controlling for an index of health- symptoms of the disorder. Therefore, a key goal of schizo-
omega-3 and omega-6 PUFA compared to women with a lower intake of these fatty acids. The effect was most minosis D is associated with persisting changes in brain
structure and function, including convergent evidence of al- droxylation of this molecule converts 25OHD to the care—infant mortality—and focusing on 49 studies that phrenia research is elucidation of etiologic factors, partic-
pronounced for omega-6 PUFAs. The RR comparing the highest to the lowest quartile of omega-6 PUFAs intake was
tered dopaminergic function. A recent case-control study active secosteroid hormone 1,25-dihydroxyvitamin D3 used similar diagnostic and ascertainment methods. The
0.78 (95% CI, 0.64-0.97). The associations were J-shaped with the strongest reduced risk for an intermediate intake of ularly environmental ones that could be readily avoided
based on neonatal blood samples identified a significant as- (1,25OHD). This hormone binds the vitamin D receptor
fish or PUFA. For fatty fish (herring/mackerel, salmon-type fish), the strongest inverse association was found for an tendencies for schizophrenia prevalence to increase with
(VDR), a member of the nuclear receptor superfamily. and used in effective, inexpensive, and ethically sound pri-
intermediate intake (RR: 0.81, 95% CI, 0.66-0.98), whereas a high intake of fatty fish was associated with an increased risk sociation between neonatal vitamin D status and risk of
of psychotic-like symptoms (RR: 1.90, 95% CI, 1.34-2.70). Women in the highest compared with the lowest quartile of schizophrenia. This article provides a concise summary In concert with a range of binding partners and coactiva- both latitude and colder climate were still large and signif- mary prevention programs.
vitamin D consumption experienced a 37% (95% CI, 22-50%) lower risk of psychotic-like symptoms. tors (including the retinoid X receptor), this phylo-
of the epidemiological and animal experimental research
genetically ancient system influences the expression icant and present on several continents. The increase in In a comprehensive survey of schizophrenia prevalence
Conclusion: Our findings raise a possibility that adult women with a high intake of fish, omega-3 or omega-6 PUFA and that has explored this hypothesis.
vitamin D have a lower rate of psychotic-like symptoms.
of many genes in mammals. Vitamin D is a potent prevalence with latitude was greater for groups with low studies around the world that were published in English
prodifferentiating and antiproliferative agent.
Key words: vitamin D/schizophrenia/epidemiology/
Vitamin D deficiency (<25 nmol/l) and insufficiency
fish consumption, darker skin, and higher infant mortali- over a period of 4 decades, Torrey1 noted 2 important
animal models/neurodevelopment/prevention
Background their lifetime [1-3]. The biological mechanisms underly- (25–50 nmo/l) are common in many nations.6–8 Hypovi- ty—consistent with a role of prenatal vitamin D deficiency patterns. First, prevalence rates varied widely at different
Even though psychoses are relatively rare, between 5-15% ing the etiology of schizophrenia and psychotic symp- taminosis D is more prevalent in winter, in high latitudes,
of the general population has been estimated to report toms are largely unknown. Genetic constitution is
in schizophrenia. Previous research indicates that poor pre- geographic sites, with the highest rate being more than 10
and in dark-skinned individuals. Migrants to European
single schizophrenia-like symptoms like delusions, magi- important [4], but environmental factors like an countries are at higher risk of hypovitaminosis D com- natal healthcare and nutrition increase risk for schizophre- times greater than the lowest. Second, there was a strong
cal thinking, and hearing internal voices at some point in unhealthy lifestyle with a poor diet may be involved [5,6]. pared with native-born.9 Compared with nonimmigrants,
Schizophrenia in adulthood is often preceded by milder Introduction nia within the same region. These adverse conditions are tendency for schizophrenia prevalence to increase with
those from Africa have the highest adjusted ORs for vi-
* Correspondence: maria.hedelin@ki.se symptoms and delusions during adolescence. The typical There is robust evidence demonstrating that the risk of tamin D deficiency (about 7-fold), followed by migrants more prevalent in developing countries concentrated near
1Department of Neuroscience, Psychiatry, Ulleråker, Uppsala University, age of onset for schizophrenia is early adulthood (20-25 increasing latitude; ie, prevalence rates tended to be
Uppsala, Sweden
years of age). Expression of psychotic symptoms in popu-
schizophrenia varies according to season of birth, place from Arab-Islamic countries (about 6-fold) and Turkey the equator, but schizophrenia prevalence is lowest at
Full list of author information is available at the end of the article of birth, and migrant status.1 We propose that develop- (about 4-fold).10 Apart from darker skin color, variables very low near the equator and to increase as one moved
sites near the equator. This suggests that schizophrenia-
© 2010 Hedelin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons mental vitamin D (DVD) deficiency underlies these related to dress (eg, wearing a veil), behavior (eg, less out- toward the poles. Both of Torrey’s conclusions were also
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
gradients.2 Over the last decade, we have undertaken door activities), and diet also contribute to an increased producing environmental factors associated with higher lat-
any medium, provided the original work is properly cited.
a coordinated program of animal experiments, assay risk of deficiency in certain ethnic groups.11,12 Urban res- reached in a survey and meta-analysis by Saha et al,2
itude may be so powerful they overwhelm protective effects
development, and analytic epidemiology in order to ex- idence is associated with an increased risk of hypovitami- which included more recent studies as well as ones pub-
plore this hypothesis. This article summarizes the current nosis, due to factors such as reduced outdoor activity and of better healthcare in industrialized countries. The ob-
access to UVB radiation.13,14
lished in languages other than English. Several other sur-
research related to this hypothesis and makes recommen- served patterns of correlations of risk factors with preva-
veys have also concluded that schizophrenia rates vary at
Ó The Author 2010. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. lence are consistent with an etiologic role for prenatal
For permissions, please email: journals.permissions@oxfordjournals.org. least 10-fold around the world, including studies using
vitamin D deficiency and exposure to certain infectious dis-](https://image.slidesharecdn.com/seitzsimplesolutionstoperplexingproblemsmarch2012-120320051052-phpapp02/85/New-Jersey-simple-solutions-to-perplexing-problems-march-2012-99-320.jpg)
![Sleep deprivation predicts drug use in teams Sleep, Drugs, Social Networks
The Spread of Sleep Loss Influences Drug Use in
Adolescent Social Networks
Sara C. Mednick1*, Nicholas A. Christakis2, James H. Fowler3
1 Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America, 2 Department of Medicine, Harvard University, Boston,
Massachusetts, United States of America, 3 Department of Political Science, University of California San Diego, La Jolla, California, United States of America
Abstract
Troubled sleep is a commonly cited consequence of adolescent drug use, but it has rarely been studied as a cause. Nor have
there been any studies of the extent to which sleep behavior can spread in social networks from person to person to
person. Here we map the social networks of 8,349 adolescents in order to study how sleep behavior spreads, how drug use
behavior spreads, and how a friend’s sleep behavior influences one’s own drug use. We find clusters of poor sleep behavior
and drug use that extend up to four degrees of separation (to one’s friends’ friends’ friends’ friends) in the social network.
Prospective regression models show that being central in the network negatively influences future sleep outcomes, but not
vice versa. Moreover, if a friend sleeps #7 hours, it increases the likelihood a person sleeps #7 hours by 11%. If a friend uses
marijuana, it increases the likelihood of marijuana use by 110%. Finally, the likelihood that an individual uses drugs increases
by 19% when a friend sleeps #7 hours, and a mediation analysis shows that 20% of this effect results from the spread of
sleep behavior from one person to another. This is the first study to suggest that the spread of one behavior in social
Figure 1. Network graph. Figure 1 is a network graph of the largest component of friends in Wave I of the Add Health study (year 1995), from a
networks influences the spread of another. The results indicate that interventions should focus on healthy sleep to prevent single school. Each node represents a subject (there are 800 shown) and its shape denotes gender (circles are female, squares are male). Lines
drug use and targeting specific individuals may improve outcomes across the entire social network. between nodes indicate relationships (arrows point from the naming friend to the named friend). Node colour denotes nightly sleep duration (red for
6 hours or less, orange for 7 hours, white for 8 hours or more) and node size indicates frequency of marijuana use (the smallest nodes do not use
marijuana, the largest report using at least daily). The network suggests clustering of both sleep and drug use behavior, and as we show in the
statistical analysis, some of the overlap in clustering may result from a causal effect of sleep on drug use. Node placement is based on the Kamada-
Citation: Mednick SC, Christakis NA, Fowler JH (2010) The Spread of Sleep Loss Influences Drug Use in Adolescent Social Networks. PLoS ONE 5(3): e9775. Kawai algorithm (see Text S1) [50].
doi:10.1371/journal.pone.0009775 doi:10.1371/journal.pone.0009775.g001
Editor: Kenji Hashimoto, Chiba University Center for Forensic Mental Health, Japan
relationships more rigorously by computing network centrality for contact who sleeps #7 hours in Wave I increases the likelihood
Received January 20, 2010; Accepted February 23, 2010; Published March 19, 2010 each subject (see Text S1). We found that centrality is significantly the ego will sleep #7 hours in Wave II by 5% (95% CI: 1% to
associated with less sleep in the future: a two-standard-deviation 10%, p = 0.02). In a continuous model with hours of sleep as the
Copyright: ß 2010 Mednick et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
increase in centrality at Wave I increases the probability of dependent variable, the effect is also significant (p = 0.03). In
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
sleeping #7 hours at Wave II by 13% (95% CI: 1% to 26%, contrast to the spread of poor sleep behavior, the number of
Funding: Mednick was supported by National Institute of Mental Health (NIMH) grant K01MH080992, Christakis and Fowler by National Institute on Aging (NIA) p = 0.03). This relationship between centrality and sleep is net of contacts who sleep .7 hours has a weak but not-quite significant
grant P01AG031093 and by grant #58729 from the Pioneer Portfolio of the Robert Wood Johnson Foundation; the National Longitudinal Study of Adolescent controls for age, race, ethnicity, household income, and mother’s (p = 0.08) positive effect on an individual’s sleep behavior.
Health was originally funded by National Institute of Child Health and Human Development. The funders had no role in study design, data collection and analysis, education. Similarly, ego drug use in Wave II is associated with the number
decision to publish, or preparation of the manuscript. In contrast, we find no significant relationship between of contacts in Wave I who use drugs, as shown in Table 2. Each
centrality and drug use (see Text S1). We also considered the additional drug-using friend increases the likelihood of use by 42%](https://image.slidesharecdn.com/seitzsimplesolutionstoperplexingproblemsmarch2012-120320051052-phpapp02/85/New-Jersey-simple-solutions-to-perplexing-problems-march-2012-163-320.jpg)
![Sleep, Drugs, Social Networks
Figure 2. Spread of sleep and drug use. Figure 2 shows that the association between ego and alter sleep is significant up to four degrees of
separation in both Wave I and Wave II. The left panel shows the percentage increase in the likelihood a person sleeps #7 hours if a friend at a certain
social distance sleeps #7 hours. The right panel shows the percentage increase in the likelihood a person uses marijuana if a friend at a certain social
distance uses marijuana. The relationship is strongest between individuals who are directly connected, but it remains significantly greater than zero
at social distances up to 4 degrees of separation in both Wave I and Wave II. Thus, a person’s sleep and drug use behavior is associated with the same
behavior of other people up to 4 degrees removed from them in the network. Error bars are derived by comparing the conditional probability of the
behavior in the observed network with an identical network in which topology and incidence of the behavior is preserved but the assignment of the
behavior is randomly distributed [19,55 2008]. Alter social distance (degrees of separation) refers to closest social distance between the alter and ego
(friend = distance 1, friend’s friend = distance 2, etc.). Error bars show 95% confidence intervals.
doi:10.1371/journal.pone.0009775.g002
that suggests the negative health behavior is more contagious than change in behavior in each alter is associated with a change in
the positive health behavior. behavior in the ego. The models adjust for sex, age, race, ethnicity,](https://image.slidesharecdn.com/seitzsimplesolutionstoperplexingproblemsmarch2012-120320051052-phpapp02/85/New-Jersey-simple-solutions-to-perplexing-problems-march-2012-164-320.jpg)
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Uploaded byDennis Embry
New Jersey simple solutions to perplexing problems march 2012
The document discusses simple solutions to complex social problems like crime, substance abuse, bullying, and more. It notes that if these issues were reduced by 50% over a decade, there would be significant positive impacts on American society. The author argues that many problems are related to common underlying causes and can be addressed through an evolutionary perspective. An evolutionary mismatch between past and current environments is proposed as contributing to issues like obesity and mental illness.
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New Jersey simple solutions to perplexing problems march 2012
- 1. Simple Solutions to Perplexing Problems: from ADHD, Obesity, Bullying, Crime, Substance Abuse and More Dennis D. Embry, Ph.D.,president/senior scientist, PAXIS Institute Co-investigator, Johns Hopkins Center for Prevention & Early Intervention Scientific advisor, Healthy Child Manitoba, Co-Investigator, School of Medicine, Yale University March 19 and 21, New Jersey, USA • Copyright 2012, PAXIS Institute. All rights reserved.
- 2. Thinking about all thechildren, youth and adults you know…
- 3.
- 4. What if…crime ordelinquency could be reduced by 50% in a decade?
- 5. What if mentalillnesses from ADHD to Depression to Schizophrenia could be reduced by 50% in a decade?
- 6. What if obesityand related illnesses like asthma or diabetes were reduced by 50% in a decade?
- 7. What if bullyingand suicides could be reduced by 50% in a decade?
- 8. What if tobacco,alcohol, illegal drug & prescription abuse were reduced by 50% in a decade?
- 9. What if childmaltreatment were reduced by 50% in a decade?
- 10. What would happento America over the next decade if all these these problems were reduced by large margins?
- 11. What would happento America over the next decade if all these these problems were reduced by large margins? What good things might happen to America over the next decade if our children, youth and adults were smarter and healthier in body, behavior, mind and spirit?
- 12. What would we,in this room, could we do personally today to help make these things happen?
- 13. How are theseall related to the same causes?
- 14. Obesity Conduct Disorders Homicide & Suicide Early Sex Early Pregnancy Addictions Aggression Asthma Disabilities How are these all related to the same causes?
- 15. Psychological flexibility isrequired…
- 16. What if wethink about these problems from an evolutionary angle…instead from a cage of past ideas?
- 17. Every species hasa Fearsome predator…
- 18. The first capital crime… …and Cainrose up and slew Abel
- 19. Humans have beenthe principle predator of other humans since the invention of stone tools…
- 20. Friend Foe “Us” “Them” The principal source of safety of humans has been other humans…
- 21. Three evolutionary mechanism fortoday’s mental gymnastics for heartfelt & principled protection of our futures… Evolutionary Mismatches Evolutionary Bottlenecks Epigensis
- 22. Selection by Consequences– A Meta-Theory with a Fractal Pattern A Fractal is a repeated Selection Level Consequences pattern at many levels Selection of Genes Genes Evolution of species Cells Epigensis Bodies Individual Behaviors Wiring of neurons Group Behaviors Human development Organizational Actions Selection of behaviors Language Reproductive behaviors Economies Behavioral economics Species Groups Organization behavior Language /Cultural evolution
- 23. Social Biological Epigenesis Environmental Inputs Genesis Nurturing or Toxic Epigenetics are Environments, These heritable Disease, or polygenes Threats changes in can be gene expression “added”, caused by “subtracted”, M mechanisms g “divided”, or or lin Phosphorlyation ph other than “multiplied.” na og Acetylation Sig en changes in the Methylation sis underlying DNA Histone Remodeling Chromatin Stucture Changes sequence. Development Immunity Stem Cell Changes Imprinting These changes Parent, can pass Three 1st Generation through multiple Generation Baby, 2nd Generation Effects generations. Reproductive Cells, 3rd Generation
- 25. Epigensis permits adaptationwithout risk of mutation, when conditions change.
- 26. Methylation dials upor down expression of genes
- 27. Methylation dials upor down expression of genes
- 29.
- 31. Daily Movement & Brain Food Physical Activity Deficiency Human Evolutionary Mismatches Ratio/Rate of Sleep Reinforcement for Sufficiency Prosocial Acts
- 32. The America’s FirstPeoples… 26,000 to 12,000 B.E. 1491 AD Disease & War Extermination, OriginalHuman Marginalization, Migrations to & Suppression North America 30,000,000 300,000 ≈ Souls in ≈ Souls North America Residential Schools; Western Diet Evolutionary bottleneck
- 33. The America’s FirstPeoples… 26,000 to 12,000 B.E. 1491 AD Disease & War Extermination, OriginalHuman Marginalization, Migrations to & Suppression North America 30,000,000 300,000 ≈ Souls in ≈ Souls Today North America Residential Schools; Western Diet Evolutionary bottleneck
- 34. Slavery The Great African Americans 1863 Middle … 1500’s to Passage Institution of Slavery Jim Crow Migration North Original Human Populations in Africa Continuing ≈Capture Trauma 30% to Separation, Exposure 50% + violence, to Toxins mortality malnutrition Evolutionary bottleneck
- 35. Slavery The Great African Americans 1863 Middle … 1500’s to Passage Institution of Slavery Jim Crow Migration North Original Human Populations in Africa Continuing ≈Capture Trauma today 30% to Separation, Exposure 50% + violence, to Toxins mortality malnutrition Evolutionary bottleneck
- 36. Example Lasting Effectsof Evolutionary Bottlenecks US Blacks Barbados St. Lucia Jamaica Popular political pundits say: Cameroon (urban) Cameroon (Rural) Nigeria (Rural) “Slavery is over. Jim Crow is 40% Slavery Exposure No Slavery Exposure over. Everybody should be over 30% all this.” Evolution is bigger than pundits, 20% and epigensis is a solution to a 10% past evolutionary problem that might come back. Evolution is 0% Hi Blood Pressure Percentage Source: Scientific American, February, 1999
- 37. Airborne lead levels predicthomicide & delinquency… African Americans have higher lead levels in the same geographic area as other peoples. African Americans absorb lead more readily. Incarcerated African Americans have the highest lead levels. Lead is concentrated in the old industrial North, where African Americans migrated in after WWII.
- 38. Audited Life Pathof a Male Convicted Criminal , “Billy” Age 4 6 8 10 12 14 16 18 20 22 24 26 Birth ADHD ODD A/D A/D A/D A/D A/D A/D A/D DSM IV TS CD SA SA SA SA SA SA SA Labels depression anxiety Self-Rep. Likes Stole Binge Daily Meth & IV Violent TV Cigarettes Drinking Marijuana Other Drugs Use School SD SD LD LD LD SED Dropout Labels Medical Prenatal Unintentional Injuries Sexually Serious Hepatitis C Smoking Ashtma Transmitted Car Crash Notes & Intentional Diseases Gunshot Low Birth Weight Bio Fussy,Irritable Injuries at Fathers Wound Fathers School Markers Mom is 16.5 years old Underactive Child Child Low omega-3 Beh. Inhibition Reduced Prefontal Function Serotonin System Lower Resting Heart Rate Case study Police Mom DV Records Has Abused Assault Calls by Mom's at School Theft Various Drug sales; Armed Felony Assault Robbery from Reclaim- Multiple Live-in Witness Complaints; ing Wyoming Offenses Homicde Truancy Blueprint by Legend Embry and ADHD = Attention Deficit Hyperactivity Disorder SA = Substance Abuse TS = Tourette's Syndrome (tics diagnosed) SD = Speech Delay Rodgers, 2002, ODD A/D = = Oppositional Defiant Disorder Antisocial Personality Disorder LD SED = = Learning Disabilityr Severe Emotional Disorder for Wyoming CD = Conduct Disorder Legislature
- 39. Audited Life Pathof a Male Convicted Criminal , “Billy” When could this path Age 4 6 8 10 12 14 16 18 20 22 24 26 have been altered Birth based on scientific ADHD ODD A/D A/D A/D A/D A/D A/D A/D evidence? DSM IV TS CD SA SA SA SA SA SA SA Labels depression anxiety Self-Rep. Likes Stole Binge Daily Meth & IV Violent TV Cigarettes Drinking Marijuana Other Drugs Use School SD SD LD LD LD SED Dropout Labels Medical Prenatal Unintentional Injuries Sexually Serious Hepatitis C Smoking Ashtma Transmitted Car Crash Notes & Intentional Diseases Gunshot Low Birth Weight Bio Fussy,Irritable Injuries at Fathers Wound Fathers School Markers Mom is 16.5 years old Underactive Child Child Low omega-3 Beh. Inhibition Reduced Prefontal Function Serotonin System Lower Resting Heart Rate Case study Police Mom DV Records Has Abused Assault Calls by Mom's at School Theft Various Drug sales; Armed Felony Assault Robbery from Reclaim- Multiple Live-in Witness Complaints; ing Wyoming Offenses Homicde Truancy Blueprint by Legend Embry and ADHD = Attention Deficit Hyperactivity Disorder SA = Substance Abuse TS = Tourette's Syndrome (tics diagnosed) SD = Speech Delay Rodgers, 2002, ODD A/D = = Oppositional Defiant Disorder Antisocial Personality Disorder LD SED = = Learning Disabilityr Severe Emotional Disorder for Wyoming CD = Conduct Disorder Legislature
- 40. Audited Life Pathof a Male Convicted Criminal , “Billy” When could this path Age 4 6 8 10 12 14 16 18 20 22 24 26 have been altered Birth based on scientific ADHD ODD A/D A/D A/D A/D A/D A/D A/D evidence? DSM IV TS CD SA SA SA SA SA SA SA Labels depression anxiety Self-Rep. Likes Stole Violent TV Cigarettes Binge Drinking Daily Marijuana Meth & IV Other Drugs Use What is the cost of human suffering to School SD SD LD LD LD SED Dropout Labels Medical Notes & Prenatal Unintentional Injuries Smoking Ashtma Sexually Serious Transmitted Car Crash Hepatitis C this family, victims, Intentional and society? Low Birth Weight Diseases Gunshot Bio Fussy,Irritable Injuries at Fathers Wound Fathers School Markers Mom is 16.5 years old Underactive Child Child Low omega-3 Beh. Inhibition Reduced Prefontal Function Serotonin System Lower Resting Heart Rate Case study Police Mom DV Records Has Abused Assault Calls by Mom's at School Theft Various Drug sales; Armed Felony Assault Robbery from Reclaim- Multiple Live-in Witness Complaints; ing Wyoming Offenses Homicde Truancy Blueprint by Legend Embry and ADHD = Attention Deficit Hyperactivity Disorder SA = Substance Abuse TS = Tourette's Syndrome (tics diagnosed) SD = Speech Delay Rodgers, 2002, ODD A/D = = Oppositional Defiant Disorder Antisocial Personality Disorder LD SED = = Learning Disabilityr Severe Emotional Disorder for Wyoming CD = Conduct Disorder Legislature
- 41. Audited Life Pathof a Male Convicted Criminal , “Billy” When could this path Age 4 6 8 10 12 14 16 18 20 22 24 26 have been altered Birth based on scientific ADHD ODD A/D A/D A/D A/D A/D A/D A/D evidence? DSM IV TS CD SA SA SA SA SA SA SA Labels depression anxiety Self-Rep. Likes Stole Violent TV Cigarettes Binge Drinking Daily Marijuana Meth & IV Other Drugs Use What is the cost of human suffering to School SD SD LD LD LD SED Dropout Labels Medical Notes & Prenatal Unintentional Injuries Smoking Ashtma Sexually Serious Transmitted Car Crash Hepatitis C this family, victims, Intentional and society? Low Birth Weight Diseases Gunshot Bio Fussy,Irritable Injuries at Fathers Wound Fathers School Markers Mom is 16.5 years old Underactive Child Child Low omega-3 Beh. Inhibition Reduced Prefontal Function Serotonin System Lower Resting Heart Rate Case study Police Mom DV Abused Assault Various Drug sales; Armed from Reclaim- What are the costs of Records Has Calls by Mom's at School Theft Felony Assault Robbery Multiple Live-in Witness Complaints; ing Wyoming Offenses Homicde Truancy Blueprint by ADHD = Legend Attention Deficit Hyperactivity Disorder SA = Substance Abuse Embry and evidence-based TS ODD = = Tourette's Syndrome (tics diagnosed) Oppositional Defiant Disorder SD LD = = Speech Delay Learning Disabilityr Rodgers, 2002, for Wyoming practices to avert? A/D = Antisocial Personality Disorder SED = Severe Emotional Disorder CD = Conduct Disorder Legislature
- 42. If modern societyis to flourish for all, we must alter the predator-prey relationships between human groups. This means fewer humans as prey, This means fewer humans as predators; This means more humans as cooperators.
- 43. Whether the talon,claw or weapon carries human rank or authority matters not to the blind engine of evolution when trying to suppress one group of humans in favor of another. Life finds a way.
- 44.
- 45. Redness, rubor, aresponse of body tissues to injury or irritation; characterized by pain and swelling and redness and heat. Excitation, excitement, fervor, fervour the state of being emotionally aroused and worked up Inflaming arousal to violent emotion Firing, ignition, kindling, lighting Hypothesis: Evolutionary “inflammatory” processes
- 46. Human Infectious/Biological Threats Human Predatory Threats Evolutionary Adaptive Responses Evolutionary Adaptive Responses (Simplified) Neuro-Hormones (Simplified) Mood Modulators Reward Threat Attributional Delay Intra-Group Generalized Localized Modulators Affiliation Bias (Inflammatory) Inflammatory Inflammatory (Anti-Inflammatory) Out-Group Response Response Stress Aggress. (Inflammatory) Modulators Intra-Group Cooperation Tit-for-Tat Beh. Bias Anti-Inflammatory Regulators Puberty/Sex (Anti-Inflammatory) Modulators (Inflammatory)
- 47. Evolutionary Path ofa Child’s Life
- 48. K R Path Path Evolutionary Path of a Child’s Life Probability of short-life and Probability of long-life and doubtful reproductive success reproductive success
- 49. Multi-Inflammatory Brain &Body Response Major Connected Ecologic Causes of the Adverse Trends Predicting MEBs & Related Illnesses Reinforcement Antecedents Physiological Verbal Relations more for anti-social cue anti-social influences trigger occasion perceived than prosocial acts and threats adverse biological threats and related behaviors mechanisms reactions
- 50. Mood Lo Reward Lo Executive Lo Behavioral Inattention Delay Function Instability Competencies Poor Immune- Motor Healing Skills Multi-Inflammatory Brain & Body Response Dysfunction Major Connected Ecologic Causes of the Adverse Trends Predicting MEBs & Related Illnesses Reinforcement Antecedents Physiological Verbal Relations more for anti-social cue anti-social influences trigger occasion perceived than prosocial acts and threats adverse biological threats and related behaviors mechanisms reactions
- 51. Substance Work Obesity, Early Mental Illness Violence Cancer School Abuse Problems etc Sex Failure Mood Lo Reward Lo Executive Lo Behavioral Inattention Delay Function Instability Competencies Poor Immune- STD’s Motor Healing Special Skills Multi-Inflammatory Brain & Body Response Dysfunction Ed Major Connected Ecologic Causes of the Adverse Trends Predicting MEBs & Related Illnesses Reinforcement Antecedents Physiological Verbal Relations more for anti-social cue anti-social influences trigger occasion perceived than prosocial acts and threats adverse biological threats and related behaviors mechanisms reactions
- 52. Obesity Conduct Disorders Homicide & Suicide Early Sex Early Pregnancy Addictions Aggression Asthma Disabilities R PATH = risky adolescence, predator and prey
- 53. The metaphor ofstopping a past epidemic…
- 54. Epidemiological survey ofmental, emotional, and behavioral disorders…an epidemic?
- 55. Depression Onset ByBirth Cohort
- 56. Depression Onset ByBirth Cohort Born Now?
- 57. Lifetime Prevalence ofDisorders in US Adolescents (N=10,123) 35% 30% 25% 20% 15% 10% 5% Merikangas et al., 2010 0% 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age in Years
- 58. Lifetime Prevalence ofDisorders in US Adolescents (N=10,123) 35% Anxiety 30% 25% 20% 15% 10% 5% Merikangas et al., 2010 0% 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age in Years
- 59. Lifetime Prevalence ofDisorders in US Adolescents (N=10,123) 35% Anxiety 30% 25% Behavior 20% 15% 10% 5% Merikangas et al., 2010 0% 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age in Years
- 60. Lifetime Prevalence ofDisorders in US Adolescents (N=10,123) 35% Anxiety 30% 25% Behavior 20% Mood 15% 10% 5% Merikangas et al., 2010 0% 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age in Years
- 61. Lifetime Prevalence ofDisorders in US Adolescents (N=10,123) 35% Anxiety 30% 25% Substance Behavior 20% Mood 15% 10% 5% Merikangas et al., 2010 0% 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Age in Years
- 62. Nearly 3 outof 4 of United States 17- to 24-year-olds are ineligible for military service for based on national epidemiological data (not service entrance exams) Medical/physical problems, 35 percent. Illegal drug use, 18 percent. Mental Category V (the lowest 10 percent of the population), 9 percent. Too many dependents under age 18, 6 percent. Criminal record, 5 percent. Army Times, Nov 5, 2009 • www.missionreadiness.org/PAEE0609.pd
- 63. Cumulative prevalence ofpsychiatric disorders by young adulthood: a prospective cohort analysis from the Great Smoky Mountains Study. By 21 years of age, 61.1% of participants had met criteria for a well-specified psychiatric disorder. An additional 21.4% had met criteria for a not otherwise specified disorder only, increasing the total cumulative prevalence for any disorder to 82.5%.
- 64. The US has75 million children and teens. 40.4 million are on psychotropic medications Wall Street Journal, 12-28-2010
- 65. Participant brain buzz… a)What does these trends mean for the future? b) What must change to fix these trends?
- 66. Evolutionary Mismatches Evolutionary Consequences Change in Increased Genes Cancer Rise in Increased Obesity Autism Rates Rise in Rise in ATOD Addictions Increased Depression Aggression Rates Rates Schizo. New cultural trends predict new challenges and risks
- 67. Evolutionary Mismatches Evolutionary Consequences Change in Increased Genes Cancer Lower Rates Rise in Increased of Positive Obesity Reinforcement Autism Rates Rise in Rise in ATOD Addictions Increased Depression Aggression Rates Rates Schizo. New cultural trends predict new challenges and risks
- 68. Evolutionary Mismatches Evolutionary Consequences Fear of Reduced Violence & Outdoor Vitamin D Change in Increased Deficiency Genes Crime Activities Cancer Increased Lower Rates Rise in Increased Electronic of Positive Obesity Media Use Reinforcement Autism Rates Rise in Rise in ATOD Omega 3 Addictions Increased Fatty Acid Depression Aggression Deficiency Rates Rates Schizo. New cultural trends predict new challenges and risks
- 69.
- 70. Apparent consumption oflinoleic acid (% of dietary energy) among Australia, Canada, UK and USA for the years 1961–2000 10 Australia Canada UK USA Apparent consumption of linoleic acid 9 8 7 (% energy) 6 5 4 3 2 1 0 1960 1965 1970 1975 1980 1985 1990 1995 2000 Evolution Neonates Breast Milk “Risky” Beh. In the Rife Valley, the Successful human American infants have Almost all adolescent human brain neonates born with been getting steadily risky behaviors have evolution the result of 60-day supply of less omega-3 (n3) and now been documented eating fish high in omega-3 in more pro-inflammatory to be related to low n3 omega-3 not subcutaneous fat omega-6 (n6) in breast and high n6 in US diet savannah animals from mother’s diet milk change in last 50 years See Broadhurst, Cunnane, & See HIbbeln et al. (2007).Maternal See Ailhaud et al. (2006).Temporal Crawford (1998). Rift Valley lake seafood consumption in pregnancy changes in dietary fats: Role of n6 fish and shellfish provided brain- and neurodevelopmental outcomes in polyunsaturated fatty acids in Hibbeln et al. (2006). Healthy intakes specific nutrition for childhood (ALSPAC study): an excessive adipose tissue of n-3 and n-6 fatty acids: estimations early Homo observational cohort study development and relationship to considering worldwide diversity. obesity Physiological Adaptation
- 71. Out of Africamigration Stringer, C. Nature 2000; 405: 24-26
- 72. Essential Fats: Metabolismand Dietary Sources
- 73. Essential Fats: Metabolismand Dietary Sources Omega-3 O C- OH 20:5n-3,eicosapentaenoic acid, EPA Seafood Breast milk (DHA) O C- OH 22:6n-3, docosahexaenoic acid, DHA (brain, retina, testis)
- 74. Essential Fats: Metabolismand Dietary Sources Omega-3 O C- OH 18:3n-3 alfa-linolenic acid, ALA Flax ~ Canola Leaf plants FADS 1-2 O C- OH 20:5n-3,eicosapentaenoic acid, EPA Seafood Breast milk (DHA) O C- OH 22:6n-3, docosahexaenoic acid, DHA (brain, retina, testis)
- 75. Essential Fats: Metabolismand Dietary Sources Omega-6 Omega-3 O O C- OH C- OH 18:2n-6 linoleic acid, 18:3n-3 alfa-linolenic acid, LA - Competition - ALA Flax Soy bean oil ~ Canola Safflower oil Leaf plants FADS 1-2 Corn oil O O C- OH C- OH 20:4n-6, arachidonic acid 20:5n-3,eicosapentaenoic acid, AA EPA Seafood Breast milk Meat, (DHA) Organs O O C- OH C- OH 22:6n-3, docosahexaenoic acid, 22:5n-6 DPA n-6 DHA (brain, retina, testis)
- 76. Essential Fats: Metabolismand Dietary Sources Omega-6 Omega-3 O O C- OH C- OH 18:2n-6 linoleic acid, 18:3n-3 alfa-linolenic acid, LA - Competition - ALA Flax Soy bean oil ~ Canola Safflower oil Leaf plants FADS 1-2 Corn oil O O C- OH C- OH 20:4n-6, arachidonic acid 20:5n-3,eicosapentaenoic acid, AA EPA Seafood Breast milk Meat, (DHA) Organs O Series 2 Series 3 O Prostaglandins Prostaglandins C- OH Thromboxanes Thromboxanes C- OH Series 4 Series 5 Leukotrienes Leukotrienes 22:6n-3, docosahexaenoic acid, 22:5n-6 DPA n-6 DHA immune - metabolic - developmental (brain, retina, testis) responses
- 77. DHA dietary deficiencyimpairs synapse development Adequate Deficient Hippocampal DHA 6.6 ± 0.7% 0.5 ± 0.1% Fatty Acids DPAn-6 0.4 ± 0.1% 4.7 ± 0.1% Cao et al. J. Neurochem. 2009
- 78. DHA dietary deficiencyimpairs synapse development Adequate Deficient Hippocampal DHA 6.6 ± 0.7% 0.5 ± 0.1% Fatty Acids DPAn-6 0.4 ± 0.1% 4.7 ± 0.1% Synapes in Hippocampal Neurons 30 µm Mother mice fed adequate of deficient diets, embryo neurons harvested day 18 Cao et al. J. Neurochem. 2009
- 79. Low maternal omega-3consumption from seafood and suboptimal verbal IQ among their children 34 32 30 28 - UK , 8y 26 III r = 0.97 Percentage of children with 24 r2 = 0.95 F=27.2 p<0.02. low verbal IQ, WISC 22 20 18 16 14 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 0.55 0.60 - Estimated omega 3 fatty acids from seafood (en %) Mother at 32 wk gestation Hibbeln et al, Lancet 2007: 369: 578-585
- 80. Oilseeds in theUS Food Supply in the 20th Century 12 10 Soybean 8 Cottonseed Corn 6 Olive Coconut 4 Disappearance (kg/person/y) 2 0 Canola 0.9 0.8 Peanut 0.7 Palm/Palm 0.6 Kernel 0.5 0.4 Safflower 0.3 0.2 Sunflower 0.1 Sesame 1989 1999 1969 1979 1949 1959 1929 1939 1909 1919 Year
- 81. 3500 All Cause Mortality (M) Stroke Mortality (M) CVD Mortality (M) 400 1400 3000 350 1200 300 2500 1000 250 2000 800 200 Total mortality (M) /100,000 Total mortality (M) /100,000 1500 Total mortality (M) /100,000 600 150 1000 400 100 Japan Japan 500 Japan Iceland 50 200 Iceland Iceland 0 0 0 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 n-3 LCFA from commodities (en%) n-3 LCFA from commodities (en%) n-3 LCFA from commodities (en%) 1200 All Cause Mortality (F) Stroke Mortality (F) CVD Mortality (F) 250 700 1000 600 200 800 500 150 400 600 Total Mortality (F)/100,000 Total mortality (F) /100,000 300 Total mortality (F) /100,000 100 400 Japan 200 Iceland 50 200 Japan 100 Japan Iceland Iceland 0 0 0 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 n-3 LCFA from commodities (en%) n-3 LCFA from commodities (en%) n-3 LCFA from commodities (en%) Hibbeln et al Am J Clin Nutr 2006; 83; 1483S-93S
- 82. 800 CHD Mortality (M) 300 CHD Mortality (F) Homicide Mortality 12 700 250 10 600 200 8 500 Total mortality (M) /100,000 400 150 Total mortality /100,000 6 Total mortality (M) /100,000 300 100 4 200 Iceland 50 2 Japan 100 Iceland Iceland Japan Japan 0 0 0 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 n-3 LCFA from commodities (en%) n-3 LCFA from commodities (en%) n-3 LCFA from commodities (en%) Postpartum Depression 30 Major Depression Bipolar Disorder 7 12 25 6 10 5 20 8 4 Lifetime prevalence (%) 15 6 Annual prevalence (%) Point prevalence (%) 3 10 4 2 Iceland 5 2 1 Japan Japan Japan Iceland 0 0 0 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 n-3 LCFA from commodities (en%) n-3 LCFA from commodities (en%) n-3 LCFA from commodities (en%) Hibbeln et al Am J Clin Nutr 2006; 83; 1483S-93S
- 84. Increasing Mismatch CausesHomicides Homicide Rate 10 8 6 4 United 2000 Kingdom 2 1961 0 0 2 4 6 8 10 Lo Hi Omega 3 Deficiency
- 85. Increasing Mismatch CausesHomicides Homicide Rate 10 8 6 4 United 2000 2000 1961 Kingdom Canada 2 1961 0 0 2 4 6 8 10 Lo Hi Omega 3 Deficiency
- 86. Increasing Mismatch CausesHomicides Homicide Rate 10 8 6 4 United 2000 2000 1961 Kingdom Canada 2 2000 1961 1961 Australia 0 0 2 4 6 8 10 Lo Hi Omega 3 Deficiency
- 87. Increasing Mismatch CausesHomicides Homicide Rate 10 8 6 1988 4 1961 Argentina United 2000 2000 1961 Kingdom Canada 2 2000 1961 1961 Australia 0 0 2 4 6 8 10 Lo Hi Omega 3 Deficiency
- 88. Increasing Mismatch CausesHomicides Homicide Rate 1985 10 United 8 States 6 1988 1999 1961 4 1961 Argentina United 2000 2000 1961 Kingdom Canada 2 2000 1961 1961 Australia 0 0 2 4 6 8 10 Lo Hi Omega 3 Deficiency
- 90. An ancient inukshukpoints the way Brief Report 30% Percentage with Psychosis at 12 months Omega-3 Fatty Acid Treatment of Women Physiological 27.5% With Borderline Personality Disorder: Kernel A Double-Blind, Placebo-Controlled Pilot Study 24% Mary C. Zanarini, Ed.D. Results: Twenty subjects were randomly assigned to 1 g of E- Frances R. Frankenburg, M.D. EPA; 10 subjects were given placebo. Ninety percent of those in both groups completed all 8 weeks of the trial. Analyses that Objective: The purpose of this study was to compare the effi- used random-effects regression modeling and controlled for cacy of ethyl-eicosapentaenoic acid (E-EPA) and placebo in the baseline severity showed E-EPA to be superior to placebo in treatment of female subjects with borderline personality disorder. Method: The authors conducted an 8-week, placebo-con- diminishing aggression as well as the severity of depressive symptoms. 18% trolled, double-blind study of E-EPA in 30 female subjects meet- Conclusions: The results of this study suggest that E-EPA may ing Revised Diagnostic Interview for Borderlines and DSM-IV cri- be a safe and effective form of monotherapy for women with teria for borderline personality disorder. moderately severe borderline personality disorder. Changes (Am J Psychiatry 2003; 160:167–169) 12% biochemistry of B orderline personality disorder is marked by notable reactivity of mood and impulsive aggression. Because re- week, were actively abusing alcohol or drugs, or were acutely sui- cidal. behavior sponse to antidepressants and mood stabilizers has typi- cally been clinically modest in this patient group (1), the Subjects were next invited to participate in face-to-face inter- views. At that time, the study procedures were fully explained, and written informed consent was obtained. Two semistructured 6% identification of novel treatments is needed. Candidates diagnostic interviews were then administered to each subject: the 4.9% include omega-3 fatty acids, such as eicosapentaenoic Structured Clinical Interview for DSM-IV Axis I Disorders (6) and acid and docosahexaenoic acid, which are commonly the Revised Diagnostic Interview for Borderlines (DIB-R) (7). Two observer-rated scales were also administered: the Modified Overt found in seafood and have beneficial effects and none of Aggression Scale (8) and the Montgomery-Åsberg Depression the adverse side effects commonly associated with phar- Rating Scale (9). macotherapy. In cross-national studies, greater seafood consumption was associated with lower rates of bipolar Subjects were included if they met both DIB-R and DSM-IV cri- teria for borderline personality disorder. They were excluded if 0% disorder (30-fold range) and major depression (50-fold range) (2). In placebo-controlled trials, a mixture of these they met current or lifetime criteria for schizophrenia, schizoaf- fective disorder, or bipolar I or bipolar II disorder or were cur- Omega-3 Placeo rently in the midst of a major depressive episode. fatty acids was found to be an effective adjunctive agent for patients suffering from bipolar disorder (3), and ethyl- Study duration was 8 weeks. Subjects were seen every week for the first month and then biweekly for the next month. Both psy- Psychosis eicosapentaenoic acid (E-EPA) was found to have a bene- chiatric rating scales were readministered at each subsequent visit. Side effects were also assessed at these visits with a struc- ficial adjunctive effect for patients suffering from recur- tured questionnaire. rent depression (4). Because of the shared symptoms of Subjects received two capsules per day (beginning the day after Source: Am. Journal of Psychiatry Source: Archives of General Psychiatry borderline personality disorder and these mood disorders, their baseline assessment); each capsule contained either 500 mg a double-blind, placebo-controlled trial of E-EPA seemed of 97% E-EPA or a placebo (mineral oil). One gram was chosen as warranted. the dose most likely to be effective on the basis of unpublished studies in depression (David Horrobin, personal communication, Feb. 1, 2001). Capsules were supplied by Laxdale Pharmaceuticals Method (Stirling, U.K.).
- 91. Reduced Felony ViolentOffenses Among Prisoners with recommended daily amounts of vitamins, minerals and essential fatty acids Ratio of Disciplinary Incidents Supplementation/Baseline 1.00 Active -37.0% Placebo -10.1% 0.75 p ‹ 0.005 p = ns 0.50 Active 0.25 Placebo 0 Before supplementation During supplementation UK maximum security prison - 338 offences among 172 prisoners over 9 months treatment in a compared to 9 months baseline. Gesch et al. Br J Psychiatry 2002, 181:22-28
- 92. Why not reproducethe rapid results in throughout Canada to get a 37% reduction in jail violence? It cost the Brits 19¢ per day or $69.35 per year.
- 93. Before Omega 3 Omega-3 can improve school grades and success Omega 3 Placebo 7 These were gains in 6 After Omega 3 academics after 3 5 months of exposure 4 to fish oil. 3 2 1 0 -1 -2 Reading Spelling See www.durhamtrial.org/
- 94. What can badbrain foods do to our teens? Double their chances of serious depression… Good Bad Odds Odds Eat Fish 2x per wk Eat Fish Rarely Eat No Seed Oil Eat Seed Oils
- 95. What can badbrain foods do to our teens? Double their chances of serious depression… Odds -0.75 0 0.75 1.50 2.25 3.00 Good Bad Odds Odds Eat Fish 2x per wk Eat Fish Rarely Eat No Seed Oil Eat Seed Oils
- 96. Increased academic and learning problems 40% 30% Percentage of 8-year olds with Poor IQ 20% 10% 0% Low Omega 3 Hi Omega 3
- 97. Omega-3 Status andUS Military Suicide Deaths Suicide Deaths of Active-Duty US Military and Omega-3 Fatty-Acid Status: A Case-Control Comparison Michael D. Lewis, MD; Joseph R. Hibbeln, MD; Jeremiah E. Johnson, RD; Yu Hong Lin, PhD; Duk Y. Hyun, BS; and James D. Loewke, BS ABSTRACT Background: The recent escalation of US military S uicide rates among active-duty US military have increased to re- cord numbers, doubling since the inception of Operation Enduring Freedom (Afghanistan) and Operation Iraqi Freedom and rivaling the suicide deaths to record numbers has been battlefield in toll on the US military.1 Army Vice–Chief of Staff General a sentinel for impaired force efficacy and has Peter W. Chiarelli described the record suicide rate as “horrible” and accelerated the search for reversible risk factors. voiced frustration that “the Army has not yet been able to identify any Objective: To determine whether deficiencies causal links among the suicide cases.”2(pA2) of neuroactive, highly unsaturated omega-3 Deficiencies of nutrients critical for brain function may be a signifi- essential fatty acids (n-3 HUFAs), in particular docosahexaenoic acid (DHA), are associated with cant contributing risk factor for psychiatric pathology, especially suicide increased risk of suicide death among a large and stress-related psychiatric symptoms.3 Highly unsaturated omega-3 random sample of active-duty US military. essential fatty acids (n-3 HUFAs), in particular docosahexaenoic acid Method: In this retrospective case-control (DHA), are selectively concentrated in neural tissues and are required study, serum fatty acids were quantified as for optimal neural function.4 These fatty acids cannot be made de novo a percentage of total fatty acids among US but are available only from dietary sources, with seafood being the richest military suicide deaths (n = 800) and controls source. Nutritional deficiencies in n-3 HUFAs may increase vulnerabil- (n = 800) matched for age, date of collection of sera, sex, rank, and year of incident. Participants ity to combat deployment stress, manifesting as psychiatric symptoms were active-duty US military personnel including adjustment disorders, major depression, impulsive violence, (2002–2008). For cases, age at death ranged and suicide.5 In civilian populations, observational studies indicate that from 17–59 years (mean = 27.3 years, SD = 7.3 low fish consumption is associated with increased risk of completed sui- years). Outcome measures included death by cides6,7 and greater suicidal ideation.8 Low DHA status was associated suicide, postdeployment health assessment questionnaire (Department of Defense Form with increased risk of past suicide attempts9 and future suicide attempts.10 2796), and ICD-9 mental health diagnosis data. In comparison to placebo, 2 grams per day of n-3 HUFA reduced suicidal Results: Risk of suicide death was 14% higher per thinking and depressive symptoms and reduced the perception of stress SD of lower DHA percentage (OR = 1.14; 95% CI, among subjects (n = 49) with deliberate self-harm.11 1.02–1.27; P < .03) in adjusted logistic regressions. These findings suggest that low DHA levels may be a contributing Among men, risk of suicide death was 62% factor for adverse psychiatric symptoms. In this study, we posited that greater with low serum DHA status (adjusted low DHA status would be associated with increased risk of suicide death OR = 1.62; 95% CI, 1.12–2.34; P < .01, comparing DHA below 1.75% [n = 1,389] to DHA of 1.75% among military personnel. Prospectively collected serum and supporting and above [n = 141]). Risk of suicide death was data were available from the Armed Forces Health Surveillance Center 52% greater in those who reported having seen (AFHSC) for a large number of active-duty suicide deaths (n = 800) and
- 98. Matsuoka BioPsychoSocial Medicine2011, 5:3 http://www.bpsmedicine.com/content/5/1/3 REVIEW Open Access Clearance of fear memory from the hippocampus through neurogenesis by omega-3 fatty acids: a novel preventive strategy for posttraumatic stress disorder? Yutaka Matsuoka1,2 Abstract Not only has accidental injury been shown to account for a significant health burden on all populations, regardless of age, sex and geographic region, but patients with accidental injury frequently present with the psychiatric condition of posttraumatic stress disorder (PTSD). Prevention of accident-related PTSD thus represents a potentially Clearance of fear memory from the hippocampus important goal. Physicians in the field of psychosomatic medicine and critical care medicine have the opportunity through neurogenesis by omega-3 fatty acids: a novel to see injured patients in the immediate aftermath of an accident. This article first briefly reviews the prevalence preventive strategy for posttraumatic stress disorder? and associated factors of accident-related PTSD, then focuses on a conceptual model of fear memory and Matsuoka proposes a new, rationally hypothesized translational preventive intervention for PTSD through promoting hippocampal neurogenesis by omega-3 fatty acid supplementation. The results of an open-label pilot trial of Matsuoka BioPsychoSocial Medicine 2011, 5:3 http://www.bpsmedicine.com/content/5/1/3 (8 February 2011) injured patients admitted to the intensive care unit suggest that omega-3 fatty acid supplementation immediately after accidental injury can reduce subsequent PTSD symptoms. Omega-3 for PTSD symptoms could be used routinely for the patients exposed to trauma
- 99. Schizophrenia Bulletin vol.35 no. 3 pp. 582–595, 2009 doi:10.1093/schbul/sbp023 Advance Access publication on April 8, 2009 Hedelin et al. BMC Psychiatry 2010, 10:38 http://www.biomedcentral.com/1471-244X/10/38 Schizophrenia Bulletin Advance Access published September 10, 2010 Relation of Schizophrenia Prevalence to Latitude, Climate, Fish Consumption, Infant Schizophrenia Bulletin doi:10.1093/schbul/sbq101 Mortality, and Skin Color: A Role for Prenatal Vitamin D Deficiency and Infections? RESEARCH ARTICLE Open Access ENVIRONMENT AND SCHIZOPHRENIA Dietary intake of fish, omega-3, omega-6 Research article Developmental Vitamin D Deficiency and Risk of Schizophrenia: A 10-Year Update polyunsaturated fatty acids and vitamin D and the Dennis K. Kinney1–3, Pamela Teixeira2, Diane Hsu2, Siena derlie variations in schizophrenia prevalence deserves high prevalence of psychotic-like symptoms in a cohort C. Napoleon2,4, David J. Crowley2, Andrea Miller2, priority. William Hyman2, and Emerald Huang2 of 33 000 women from the general population x John J. McGrath*,1,2,3, Thomas H. Burne1,2, Francois Feron4, Allan Mackay-Sim5, and Darryl W. Eyles1,2 ´ 2 Key words: epidemiology/etiology/immune function/ 1 Queensland Center for Mental Health Research, The Park Center for Mental Health, Wacol, Queensland 4076, Australia; 2Queensland Genetics Laboratory, McLean Hospital, Belmont, MA; 3De- Maria Hedelin*1,2, Marie Löf3, Marita Olsson3,4, Tommy Lewander1, Björn Nilsson1, Christina M Hultman1,3 and Brain Institute, University of Queensland, St Lucia, Queensland 4076 Australia; 3Department of Psychiatry, University of Queensland, St partment of Psychiatry, Harvard Medical School, Boston, MA; prenatal/geography/risk factor Lucia, Queensland 4076 Australia; 4Neurobiologie des Interactions Cellulaires et Neurophysiopathologie (CNRS UMR 6184), Universite de ´ Downloaded from http://schizophreniabulletin.oxfordjournals.org/ by guest on February 10, 2012 Elisabete Weiderpass2,3,5 ´ ´ ´ ´ ´ ´ la Mediterranee (Aix-Marseille II), Faculte de Medecine Nord, Institut Federatif de Recherche Jean Roche (IFR11), Marseille, France; 4 Wellesley College, Wellesley, MA 5 National Center for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland Downloaded from schizophreniabulletin.oxfordjournals.org at UQ Library on September 19, 2010 4111, Australia *To whom correspondence should be addressed; tel: þ61-7-3346-6372, fax: þ61-7-3271-8698, e-mail: john_mcgrath@qcmhr.uq.edu.au Abstract Previous surveys found a large (>10-fold) variation in Introduction Background: Low intake of fish, polyunsaturated fatty acids (PUFA) and vitamin D deficiency has been suggested to play a role in the development of schizophrenia. Our aim was to evaluate the association between the intake of schizophrenia prevalence at different geographic sites Schizophrenia is an unusually burdensome disorder be- different fish species, PUFA and vitamin D and the prevalence of psychotic-like symptoms in a population-based study There is an urgent need to generate and test candidate risk dations for future research. Key features of the evidence factors that may explain gradients in the incidence of are summarized in table 1. and a tendency for prevalence to increase with latitude. cause of the great economic costs of extensive care and among Swedish women. Methods: Dietary intake was estimated using a food frequency questionnaire among 33 623 women aged 30-49 years schizophrenia. Based on clues from epidemiology, we pro- We conducted meta-analyses of prevalence studies to inves- loss of economic productivity, as well as the personal suf- at enrolment (1991/92). Information on psychotic-like symptoms was derived from a follow-up questionnaire in the posed that developmental vitamin D deficiency may con- tigate whether these findings pointed to underlying etiologic years 2002/03. Participants were classified into three predefined levels: low, middle and high frequency of symptoms. tribute to the risk of developing schizophrenia. This Vitamin D—The Basics fering and stigma, which often affect a patient and his or The association between diet and psychotic-like symptoms was summarized in terms of relative risks (RR) and hypothesis may explain diverse epidemiological findings in- factors in schizophrenia or were the result of methodolog- her family for most of the patient’s life. Moreover, for Ultra Violet B (UVB) radiation on the epidermis converts corresponding 95% confidence intervals and was evaluated by energy-adjusted multinomial logistic regression. cluding season of birth, the latitude gradients in incidence a cholesterol metabolite to vitamin D3 (cholecalciferol; ical artifacts or the confounding of sites’ latitude with level most patients there is still no cure or even an effective Results: 18 411 women were classified as having a low level of psychotic-like symptoms, 14 395 as middle and 817 as and prevalence, the increased risk in dark-skinned migrants to certain countries, and the urban-rural gradient. Animal a preprohormone). This is subsequently hydroxylated of healthcare at those sites. We found that these patterns way of treating many of the most disabling, ‘‘negative’’ having a high level. The risk of high level symptoms was 53% (95% CI, 30-69%) lower among women who ate fish 3-4 to 25-hydroxyvitamin D3 (25OHD), a prehormone com- times per week compared to women who never ate fish. The risk was also lower for women with a high intake of experiments demonstrate that transient prenatal hypovita- monly used to measure vitamin D status. A second hy- were still present after controlling for an index of health- symptoms of the disorder. Therefore, a key goal of schizo- omega-3 and omega-6 PUFA compared to women with a lower intake of these fatty acids. The effect was most minosis D is associated with persisting changes in brain structure and function, including convergent evidence of al- droxylation of this molecule converts 25OHD to the care—infant mortality—and focusing on 49 studies that phrenia research is elucidation of etiologic factors, partic- pronounced for omega-6 PUFAs. The RR comparing the highest to the lowest quartile of omega-6 PUFAs intake was tered dopaminergic function. A recent case-control study active secosteroid hormone 1,25-dihydroxyvitamin D3 used similar diagnostic and ascertainment methods. The 0.78 (95% CI, 0.64-0.97). The associations were J-shaped with the strongest reduced risk for an intermediate intake of ularly environmental ones that could be readily avoided based on neonatal blood samples identified a significant as- (1,25OHD). This hormone binds the vitamin D receptor fish or PUFA. For fatty fish (herring/mackerel, salmon-type fish), the strongest inverse association was found for an tendencies for schizophrenia prevalence to increase with (VDR), a member of the nuclear receptor superfamily. and used in effective, inexpensive, and ethically sound pri- intermediate intake (RR: 0.81, 95% CI, 0.66-0.98), whereas a high intake of fatty fish was associated with an increased risk sociation between neonatal vitamin D status and risk of of psychotic-like symptoms (RR: 1.90, 95% CI, 1.34-2.70). Women in the highest compared with the lowest quartile of schizophrenia. This article provides a concise summary In concert with a range of binding partners and coactiva- both latitude and colder climate were still large and signif- mary prevention programs. vitamin D consumption experienced a 37% (95% CI, 22-50%) lower risk of psychotic-like symptoms. tors (including the retinoid X receptor), this phylo- of the epidemiological and animal experimental research genetically ancient system influences the expression icant and present on several continents. The increase in In a comprehensive survey of schizophrenia prevalence Conclusion: Our findings raise a possibility that adult women with a high intake of fish, omega-3 or omega-6 PUFA and that has explored this hypothesis. vitamin D have a lower rate of psychotic-like symptoms. of many genes in mammals. Vitamin D is a potent prevalence with latitude was greater for groups with low studies around the world that were published in English prodifferentiating and antiproliferative agent. Key words: vitamin D/schizophrenia/epidemiology/ Vitamin D deficiency (<25 nmol/l) and insufficiency fish consumption, darker skin, and higher infant mortali- over a period of 4 decades, Torrey1 noted 2 important animal models/neurodevelopment/prevention Background their lifetime [1-3]. The biological mechanisms underly- (25–50 nmo/l) are common in many nations.6–8 Hypovi- ty—consistent with a role of prenatal vitamin D deficiency patterns. First, prevalence rates varied widely at different Even though psychoses are relatively rare, between 5-15% ing the etiology of schizophrenia and psychotic symp- taminosis D is more prevalent in winter, in high latitudes, of the general population has been estimated to report toms are largely unknown. Genetic constitution is in schizophrenia. Previous research indicates that poor pre- geographic sites, with the highest rate being more than 10 and in dark-skinned individuals. Migrants to European single schizophrenia-like symptoms like delusions, magi- important [4], but environmental factors like an countries are at higher risk of hypovitaminosis D com- natal healthcare and nutrition increase risk for schizophre- times greater than the lowest. Second, there was a strong cal thinking, and hearing internal voices at some point in unhealthy lifestyle with a poor diet may be involved [5,6]. pared with native-born.9 Compared with nonimmigrants, Schizophrenia in adulthood is often preceded by milder Introduction nia within the same region. These adverse conditions are tendency for schizophrenia prevalence to increase with those from Africa have the highest adjusted ORs for vi- * Correspondence: maria.hedelin@ki.se symptoms and delusions during adolescence. The typical There is robust evidence demonstrating that the risk of tamin D deficiency (about 7-fold), followed by migrants more prevalent in developing countries concentrated near 1Department of Neuroscience, Psychiatry, Ulleråker, Uppsala University, age of onset for schizophrenia is early adulthood (20-25 increasing latitude; ie, prevalence rates tended to be Uppsala, Sweden years of age). Expression of psychotic symptoms in popu- schizophrenia varies according to season of birth, place from Arab-Islamic countries (about 6-fold) and Turkey the equator, but schizophrenia prevalence is lowest at Full list of author information is available at the end of the article of birth, and migrant status.1 We propose that develop- (about 4-fold).10 Apart from darker skin color, variables very low near the equator and to increase as one moved sites near the equator. This suggests that schizophrenia- © 2010 Hedelin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons mental vitamin D (DVD) deficiency underlies these related to dress (eg, wearing a veil), behavior (eg, less out- toward the poles. Both of Torrey’s conclusions were also Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in gradients.2 Over the last decade, we have undertaken door activities), and diet also contribute to an increased producing environmental factors associated with higher lat- any medium, provided the original work is properly cited. a coordinated program of animal experiments, assay risk of deficiency in certain ethnic groups.11,12 Urban res- reached in a survey and meta-analysis by Saha et al,2 itude may be so powerful they overwhelm protective effects development, and analytic epidemiology in order to ex- idence is associated with an increased risk of hypovitami- which included more recent studies as well as ones pub- plore this hypothesis. This article summarizes the current nosis, due to factors such as reduced outdoor activity and of better healthcare in industrialized countries. The ob- access to UVB radiation.13,14 lished in languages other than English. Several other sur- research related to this hypothesis and makes recommen- served patterns of correlations of risk factors with preva- veys have also concluded that schizophrenia rates vary at Ó The Author 2010. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. lence are consistent with an etiologic role for prenatal For permissions, please email: journals.permissions@oxfordjournals.org. least 10-fold around the world, including studies using vitamin D deficiency and exposure to certain infectious dis-
- 100. Bridging human mismatch Balancing the omega -6 and omega-3 ratios
- 101. Neither PAXIS norDr. Embry Where and how can we have any financial interest in an omega-3 supplement. correct the brain food? Home? Schools? Child-care and youth serving organizations? Workplaces? Prisons and jails? Mental health and substance abuse treatment? Doctors, clinics and insurance payers? Local, state, and federal policies?
- 102. If we canpredict human predators and prey from omega-3 fatty acid and vitamin D3 deficiency… Then, why not prevent it using remedying this deficiency that both ancient wisdom recognizes and science confirms? Neither Dr. Embry nor PAXIS have any financial involvement with any manufacturer or distributor of omega-3 or vitamin D products.
- 103. Evolution Matching Law Reinforcer Diet “Risky” Beh. Humans are A simple 3-term Multiple data sets and When children or youth apparently unique in algebra formula controlled studies show receive differential rates the ability to use predicts either risky or that children and youth of peer and adult non-risky behavior in in general receive low reinforcement for arbitrary sounds and human in real-world levels of reinforcement symbols to reinforce prosociality virtually all for prosociality, with behavior in others. settings related to risk behaviors decline. adverse effects on differential verbal/social behavior See Hayes, Barnes-Holmes & reinforcement. See Biglan & Hinds, E. (2009). Evolving Roche. (2001). Relational frame See Plaud, (1992). The prediction and control of behavior revisited: A review See Biglan et al. (2004). Helping prosocial and sustainable theory: A post-Skinnerian account neighborhoods and communities. of human language and cognition of the matching law.of intergroup Adolescents at Risk. conflict Reinforcement Adaptation
- 104. Paying attention, beinggood? What are the social reinforcers for…
- 105. Paying attention, beinggood? Showing off, being bad? What are the social reinforcers for…
- 106. A formula topredict in class? # rewards Percent of for “good” Good # rewards Behavior # rewards for “good” + for “bad”
- 107. A formula topredict in class? # rewards Percent of for “good” Good =# rewards # rewards Behavior for “good” + for “bad”
- 108. A formula topredict behavior in class? 1 “Good” Percent of Good 10 (to 20) Behavior 1 “Good” + “Bad’s”
- 109. A formula topredict behavior in class? 1 “Good” Percent of Good = 10 (to 20) Behavior 1 “Good” + “Bad’s”
- 110. A formula topredict behavior in class? Percent of Good Behavior = 4.7% to 9% How much engaged learning and academic instruction can happen now?
- 111. Footnote: This formulais based on the “Matching Law,” one of the most cited papers in psychology by Herrnstein, 1970
- 112. Oh, #$&#! # rewards Percent of for “Good” What can I do to Good =# rewards # rewards solve this? Behavior for “Good” + for “Bad” Footnote: This formula is based on the “Matching Law,” one of the most cited papers in psychology by Herrnstein, 1970
- 113. Age 4 6 8 10 12 14 16 18 20 22 24 26 Birth A Life Map of Travail ADHD ODD A/D A/D A/D A/D A/D A/D A/D DSM IV TS CD SA SA SA SA SA SA SA Labels depression anxiety Self-Rep. Likes Stole Binge Daily Meth & IV Violent TV Cigarettes Drinking Marijuana Other Drugs Use School SD SD LD LD LD SED Dropout Labels Medical Prenatal Unintentional Injuries Sexually Serious Hepatitis C Smoking Ashtma Transmitted Car Crash Notes & Intentional Diseases Gunshot Low Birth Weight Bio Fussy,Irritable Injuries at Fathers Wound Fathers School Markers Mom is 16.5 years old Underactive Child Child Low CSF Beh. Inhibition Reduced Prefontal Function Serotonin System Lower Resting Heart Rate Case study Police Mom DV Records Has Abused Assault Calls by Mom's at School Theft Various Drug sales; Armed Felony Assault Robbery from Reclaim- Multiple Live-in Witness Complaints; ing Wyoming Offenses Homicde Truancy Blueprint by Legend Embry and ADHD = Attention Deficit Hyperactivity Disorder SA = Substance Abuse TS = Tourette's Syndrome (tics diagnosed) SD = Speech Delay Rodgers, 2002, ODD A/D = = Oppositional Defiant Disorder Antisocial Personality Disorder LD SED = = Learning Disabilityr Severe Emotional Disorder for Wyoming CD = Conduct Disorder Legislature
- 114. Remember the life case histories presented? Source: Dr.Tom Dishion
- 115. Remember the life case histories presented? Source: Dr.Tom Dishion
- 116. Simplified Matching Law B = predicted behavior rate k = A “rubber-band” like asymptotic Halvor Teigen, K. (2002). One hundred years of laws in psychology. American constant Journal of Psychology, 115(1), 103-118. rp =rate of reinforcement for target Pierce, W. D., & Epling, W. F. (1995). The applied importance of research on the matching law. Journal of Applied Behavior Analysis, 28(2), 237-241. behavior Correia, C. J., Simons, J., Carey, K. B., & Borsari, B. E. (1998). Predicting drug use: rv =rate of reinforcement for all other Application of behavioral theories of choice. Addictive Behaviors, 23(5), 705-710. behaviors
- 117. Language, physiological, medicationor substance abuse effect on behavior This “selection by consequences” mathematical law predicts wiring of the brain neurons, bullying, criminal behavior, drug addictions, and other predatory/ prey outcomes. So, what if… Rate influenced by: Rate influenced by: • Reinforcements • Reinforcement • Antecedents • Antecedents • Relational-frames • Relational-frames
- 118. PAX GBG: AnExample Behavioural Vaccine Muriel Saunders Read about multiple scientific studies on the “Good Behavior Game” at www.pubmed.gov
- 119. How Manitoban teachers are teachingand using the PAX Good Behavior Game
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- 121.
- 122.
- 123. CUES PAX GBG
- 124. CUES PAX GBG
- 125. They teach childrena vision of a wonderful school
- 127. OK tm tm Bien Not OK Pas bien tm À Vive bas les les GO PAX ! ! No Spleems Spleem © 2002-2012, PAXIS Institute PAX Peeling cards up is a spleem for your team (Si tu soulèves les cartes, c’est un Spleem à ton équipe.) To create more good, By sweeping away the called “PAX” “bad”, called “Spleems”
- 128. Playing the PAXGame by Teams: During any regular teaching & learning activity The Blue Team The Red Team The Yellow Team
- 129. The Aim: to Win PAX Ms. Dion Jan 23 Spleems are counted and marked with neutral Blue tone for the team, not the individual child. Red Teams who have 3 or fewer Spleems win. Yellow Winning teams earn a “Granny’s Wacky Prize”. Team having 4 or more Spleems lose that game. PAX Minutes = winning teams x minutes played.
- 130. The Aim: to Win PAX Ms. Dion Jan 23 Spleems are counted and marked with neutral Blue tone for the team, not the individual child. Red Teams who have 3 or fewer Spleems win. Yellow Winning teams earn a “Granny’s Wacky Prize”. Team having 4 or more Spleems lose that game. PAX Minutes = winning teams x minutes played.
- 131. The Aim: to Win PAX Ms. Dion Jan 23 Spleems are counted and marked with neutral Blue tone for the team, not the individual child. Red Teams who have 3 or fewer Spleems win. Yellow Winning teams earn a “Granny’s Wacky Prize”. Team having 4 or more Spleems lose that game. 20 40 PAX Minutes = winning teams x minutes played.
- 132. The Aim: to Win PAX Ms. Dion Jan 23 Spleems are counted and marked with neutral Blue tone for the team, not the individual child. Red Teams who have 3 or fewer Spleems win. Yellow Winning teams earn a “Granny’s Wacky Prize”. Team having 4 or more Spleems lose that game. 20 40 PAX Minutes = winning teams x minutes played.
- 133. The Aim: to Win PAX Ms. Dion Jan 23 Spleems are counted and marked with neutral Blue tone for the team, not the individual child. Red Teams who have 3 or fewer Spleems win. Yellow Winning teams earn a “Granny’s Wacky Prize”. Team having 4 or more Spleems lose that game. 20 20 40 60 PAX Minutes = winning teams x minutes played.
- 134. Winning teams get“Granny’s Wacky Prizes” Brief (30 seconds or so) activity rewards for winning game Start and stop with non-verbal cue Based on mystery motivator and Premack Principle Function as “intrinsic motivators” As-tu J’ai les Got Got PAX? des Surprises Got PAX? Got PAX? I’ve got PAX? PAX? fofolles de Mémé Granny’s Wacky Prizes
- 135. The PAX Gameteaches Individual and group goal orientation/ dependency Voluntary control over attention Self-regulation, self-calming under excitement Self-regulation during failure or disappointment Delay of gratification Cooperation to achieve a bigger goal How to ignore accidental attention to negative behavior from peers Mild sanctions for anti-social acts by others
- 136. View the CanadianBroadcast Corporation Video on Manitoba
- 137. Seine River PilotDemonstration April, 2011 – Principals and key Disruptions by All Seine River First Graders staff trained for two days for all Rate Per Hour Per Child 12 12 schools. 10 40.8% 45% April, 2011 – First grade 8 Reduction classrooms then trained that 6 week 4 April through May – Each 2 successive month other grades 0 trained, including 8th grade Before After (Baseline) PAX GBG
- 138. Longitudinal Johns HopkinsStudies of GBG Kindergarden Every child rated by teachers
- 139. Longitudinal Johns HopkinsStudies of GBG Kindergarden Every child rated by teachers
- 140. Longitudinal Johns HopkinsStudies of GBG Kindergarden First Grade Every GBG child rated by teachers NO GBG Tested in 41 first- and second-grade classrooms within 19 elementary schools with two consecutive groups of first graders.
- 141. Longitudinal Johns HopkinsStudies of GBG Grades 2 thru 12 Kindergarden First Grade Follow Up Every GBG No More GBG child rated by teachers NO GBG No GBG Tested in 41 first- Purpose: To find out if and second-grade GBG affected their classrooms within adolescent lives. 19 elementary Note: Some kids got schools with two GBG in 1st Grade only, consecutive groups and some in both 1st & of first graders. 2nd grade,
- 142. Longitudinal Johns HopkinsStudies of GBG Grades 2 thru 12 Young Adulthood Kindergarden First Grade Follow Up Follow Up GBG Age Age Age Every No More GBG child 19-21 26 30 rated by Age Age Age teachers NO GBG No GBG 19-21 26 30 Tested in 41 first- Purpose: To find out if Purpose: To find out if and second-grade GBG affected their GBG affected their classrooms within adolescent lives. adult lives. 19 elementary Note: Some kids got schools with two GBG in 1st Grade only, consecutive groups and some in both 1st & of first graders. 2nd grade,
- 143. District Priorities: Our Priorities: Our Priorities: Preparing Your Student For The Future Scholarship Scholarship Scholarship Mt. Adams School News Citizenship Citizenship Citizenship Leadership Leadership Leadership Sportsmanship Sportsmanship Sportsmanship May 2011 Volume 5, Issue 9 Editor: Linda King Important Dates Early Release: May 2, 9, 16, 23 What we are seeing so far is Central Washington Junior Livestock Show May 2-4, Toppenish Rodeo Grounds JOM/IPEC Recognition Dinner 1. decreased disciplinary referrals May 11, 6:00 pm, Middle School Gym Spring Community Meeting with Board 2. increased attendance May 12, 6:00 pm, Harrah Board of Director Meeting May 16, 6:00 pm, Harrah 3. increased time on task and decreased transition JOM Meeting, May 17, 6:00 pm, White Swan Senior Banquet, May 19, 7:00 pm, White Swan times which=more time teaching No School, May 30, Memorial Day You are Invited to an Informal Chat Students Help Classmate Communicate Shane Carey is a freshman student with Cerebral Palsy. While he cannot walk 4. improvement of school climate where students with the Mt. Adams School Board or talk, he is fully aware of what is going on around him. However, making his needs known to others is a serious problem. He has a custom computer that he are being kinder and helping each other more, May 12, 6:00 pm, at Harrah Elementary Ask the questions you feel need to be an- Game Teaches Good Behavior can use to communicate, but, without a device to attach it to his wheel chair, it can only be used in the classroom. The stand he needs was ordered two years staff are feeling less stress. swered, make suggestions and pass on your ock’s 5th ago If your a complicated process that appears to have led nowhere. unusual new and was first grader is coming home speaking some Demand ideas. This is an opportunity to get a better for such specialized items is small so the number of venders who can provide ntral words like PAX, Spleem longer seemed your child is participating in an idea of what your child’s education them is equally small. Waiting anyand Toodle, a very poor option. haracter- innovative program that ESD 105 who works with Shane took the prob- The educational specialist from Nancy Fiander, Elder & PAX Coach, Harrah Elementary focuses on teaching very young children opportunities will look like in the future. e bumpy lem to Rob Ford.good behavior that makes past in the special ed depart- enjoy- the kind of He has worked with Shane in the the classroom a more ment and nowproductiveeducational assistant in the vocational teachers. able and works as an place for both students and shop program and the Intro to Engineering class, grades 10-12. Could a stand be built for en better. Shane right here at hisis funded by a $75,000 a year, Five-Year The program own school? Preventa- la mon- tive saw the possibleSchools the perfect real world experience by the stu- and Ford Practices In project as grant, which was written for School ful in dents in the engineering and welding classes. The engineering students Community Programs Coordinator Nancy Fiander. The grant dol- (pictured above with Shane and Ford on the left), first brain-stormed the problem, a suc- took measurements and then sessions, travel, and substitutes for participat- lars will fund training began creating design drawings of what they be- ced the lieved the stand should look like as well it would function. Using 3-D animation ing teachers and staff, and how as paying for instructional materials
- 144.
- 145. Timeline of Benefits… FirstMonth More time for Less stress for teaching and learning Staff & Students First Year Better Fewer Fewer Service Less Happier Less Better Attendance Referrals Needs Illness Families Vandalism Academics 2nd & 3rd Years ADHD Oppositional Special Education Averted Defiance Averted Averted 5-15 Years No Less Less Conduct Less Less Crime, High School Tobacco Alcohol Disorders Depression Violence, Suicide Grad & University
- 146. OUTCOMES STUDENT GROUPS GBG CLASSROOM STANDARD CLASSROOM Drug abuse and All males 19 percent 38 percent dependence disorders Highly aggressive males 29 percent 83 percent Regular smoking All males 6 percent 19 percent Highly aggressive males 0 percent 40 percent First graders Alcohol abuse and All males and females 13 percent 20 percent exposed to GBG dependence disorders for one year had Antisocial personality Highly aggressive males 40 percent 100 percent these benefits at disorder (ASPD) age 21. Violent and criminal Highly agressive males 34 percent 50 percent behavior (and ASPD) Service use for All males 25 percent 42 percent problems with behavior, emotions, drugs, or alcohol Suicidal thoughts All females 9 percent 19 percent All males 11 percent 24 percent SOURCE: Kellam, S. G., Mackenzie, A. C., Brown, C. H., Poduska, J. M., Wang, W., Petras, H., & Wilcox, H. C. (2011). The good behavior game and the future of prevention and treatment. Addict Sci Clin Pract, 6(1), 73-84. Read this and other studies about the Good Behavior Game at www.pubmed.gov
- 148. How much mightPAX GBG save New Jersey? To do PAX GBG will cost about $150 to protect our children for life from mental illnesses, behavioral problems, drug addictions, becoming a criminal, trying suicide, dying from tobacco or alcohol related illnesses. And, it increases their academic success—including university entry. PAX GBG pays back $14,300 to individuals, taxpayers, and others per student exposed in First Grade over 15 years. Cost Savings Assuming 105,000 First Graders each year, that saves $1.5 Billion every First Grade cohort. Source: Aos, S., Lee, S., Drake, E., Pennucci, A., Klima, T., Miller, M., et al. (2011). Return on Investment: Evidence-Based Options to Improve Statewide Outcomes. (July), 8. Retrieved from http://www.wsipp.wa.gov/rptfiles/11-07-1201.pdf
- 149. How much mightPAX GBG save New Jersey? To do PAX GBG will cost about $150 to protect our children for life from mental illnesses, behavioral problems, drug addictions, becoming a criminal, trying suicide, dying from tobacco or alcohol related illnesses. And, it increases their academic success—including university entry. PAX GBG pays back $14,300 to individuals, taxpayers, and others per student exposed in First Grade over 15 years. Cost Savings Assuming 105,000 First Graders each year, that saves $1.5 Billion every First Grade cohort. And the cost? Source: Aos, S., Lee, S., Drake, E., Pennucci, A., Klima, T., Miller, M., et al. (2011). Return on Investment: Evidence-Based Options to Improve Statewide Outcomes. (July), 8. Retrieved from http://www.wsipp.wa.gov/rptfiles/11-07-1201.pdf
- 150. How much mightPAX GBG save New Jersey? To do PAX GBG will cost about $150 to protect our children for life from mental illnesses, behavioral problems, drug addictions, becoming a criminal, trying suicide, dying from tobacco or alcohol related illnesses. And, it increases their academic success—including university entry. PAX GBG pays back $14,300 to individuals, taxpayers, and others per student exposed in First Grade over 15 years. Cost Savings Assuming 105,000 First Graders each year, that saves $1.5 Billion every First Grade cohort. And the cost? $15.7 million per cohort Source: Aos, S., Lee, S., Drake, E., Pennucci, A., Klima, T., Miller, M., et al. (2011). Return on Investment: Evidence-Based Options to Improve Statewide Outcomes. (July), 8. Retrieved from http://www.wsipp.wa.gov/rptfiles/11-07-1201.pdf
- 151. Where and howcan we correct this reinforcement mismatch in classrooms? Schools? Child-care and youth serving organizations? Doctors, clinics and insurance payers? Local, state, and federal policies?
- 152. Built Evolution Environment Play Diet “Risky” Beh. Running and walking Mixed environments American children have The change in play is 5-10 miles per day in versus “residential” dramatically changed associated with an the pursuit of settings increase their play from outdoor increase in most DSM- play, imaginative play, IV plus many behavior reinforcers has long grades and reduce free-play, multi-age play, history in humans. conduct problems. and academic and rough and tumble Such movement problems plus health play to solo screen time increases BDNF. See Szapocznik et al. (2006). The issues in youth. impact of the built environment on See Clements (2004). An See Kuo & Taylor (2004). A potential See Bramble & Lieberman (2004). children's school conduct grades: Investigation of the Status of Outdoor natural treatment for attention-deficit/ Endurance running and the The role of diversity of use in a Play. Contemporary Issues in Early hyperactivity disorder: evidence from a evolution of Homo Hispanic neighborhood Childhood. national study. Antecedent Movement Inflammatory/Anti-inflammatory
- 153. A simple interventionthat reduces ADHD and autism symptoms
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- 155. Structured play atrecess…
- 156. Where and howcan we correct this movement mismatch among children? Schools? Child-care and youth serving organizations? Doctors, clinics and insurance payers? Local, state, and federal policies?
- 157. Cultural Trend: Sleep Deprivation IOM Report (IOM, page 212)
- 158. Data on SleepDeprivation On the average, school-age children have a sleep deficit of .5 - 1.5 hours per night. This multiplies out to a deficit of 2.5 - 7.5 hours per five day school week.
- 159. Sleep Deprivation causedby… TV’s in children’s bedrooms Televisions in Children’s Bedrooms in 1997 1 Computers in bedrooms 0 Gameboys in bedrooms 0 …Rapidly increasing since 0 25.6% 37..8% 55.8% 1990 0 Preschoolers (2-5) Elementary (6-11) Secondary (12-17)
- 160. New Major Causeof Sleep Deprivation… 91% of teens (ages 15-17) have web-enabled cellphones. Many teens stay up to 2am or so texting 25.6% 37..8% 55.8%
- 161. Sleep Deprivation causes… • Significant risk of alcohol, tobacco and other drug use • Increased risk of early sexual behavior and violence • School problems 25.6% 37.%% 55.8% • Family/home problems
- 162. Sleep Improvement evidence-basedkernels Curfew one-hour before bedtime for: Televisions Computers Gameboys Cellphones 25.6% 37.%% 55.8% General reduction of passive media
- 163. Sleep deprivation predictsdrug use in teams Sleep, Drugs, Social Networks The Spread of Sleep Loss Influences Drug Use in Adolescent Social Networks Sara C. Mednick1*, Nicholas A. Christakis2, James H. Fowler3 1 Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America, 2 Department of Medicine, Harvard University, Boston, Massachusetts, United States of America, 3 Department of Political Science, University of California San Diego, La Jolla, California, United States of America Abstract Troubled sleep is a commonly cited consequence of adolescent drug use, but it has rarely been studied as a cause. Nor have there been any studies of the extent to which sleep behavior can spread in social networks from person to person to person. Here we map the social networks of 8,349 adolescents in order to study how sleep behavior spreads, how drug use behavior spreads, and how a friend’s sleep behavior influences one’s own drug use. We find clusters of poor sleep behavior and drug use that extend up to four degrees of separation (to one’s friends’ friends’ friends’ friends) in the social network. Prospective regression models show that being central in the network negatively influences future sleep outcomes, but not vice versa. Moreover, if a friend sleeps #7 hours, it increases the likelihood a person sleeps #7 hours by 11%. If a friend uses marijuana, it increases the likelihood of marijuana use by 110%. Finally, the likelihood that an individual uses drugs increases by 19% when a friend sleeps #7 hours, and a mediation analysis shows that 20% of this effect results from the spread of sleep behavior from one person to another. This is the first study to suggest that the spread of one behavior in social Figure 1. Network graph. Figure 1 is a network graph of the largest component of friends in Wave I of the Add Health study (year 1995), from a networks influences the spread of another. The results indicate that interventions should focus on healthy sleep to prevent single school. Each node represents a subject (there are 800 shown) and its shape denotes gender (circles are female, squares are male). Lines drug use and targeting specific individuals may improve outcomes across the entire social network. between nodes indicate relationships (arrows point from the naming friend to the named friend). Node colour denotes nightly sleep duration (red for 6 hours or less, orange for 7 hours, white for 8 hours or more) and node size indicates frequency of marijuana use (the smallest nodes do not use marijuana, the largest report using at least daily). The network suggests clustering of both sleep and drug use behavior, and as we show in the statistical analysis, some of the overlap in clustering may result from a causal effect of sleep on drug use. Node placement is based on the Kamada- Citation: Mednick SC, Christakis NA, Fowler JH (2010) The Spread of Sleep Loss Influences Drug Use in Adolescent Social Networks. PLoS ONE 5(3): e9775. Kawai algorithm (see Text S1) [50]. doi:10.1371/journal.pone.0009775 doi:10.1371/journal.pone.0009775.g001 Editor: Kenji Hashimoto, Chiba University Center for Forensic Mental Health, Japan relationships more rigorously by computing network centrality for contact who sleeps #7 hours in Wave I increases the likelihood Received January 20, 2010; Accepted February 23, 2010; Published March 19, 2010 each subject (see Text S1). We found that centrality is significantly the ego will sleep #7 hours in Wave II by 5% (95% CI: 1% to associated with less sleep in the future: a two-standard-deviation 10%, p = 0.02). In a continuous model with hours of sleep as the Copyright: ß 2010 Mednick et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits increase in centrality at Wave I increases the probability of dependent variable, the effect is also significant (p = 0.03). In unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. sleeping #7 hours at Wave II by 13% (95% CI: 1% to 26%, contrast to the spread of poor sleep behavior, the number of Funding: Mednick was supported by National Institute of Mental Health (NIMH) grant K01MH080992, Christakis and Fowler by National Institute on Aging (NIA) p = 0.03). This relationship between centrality and sleep is net of contacts who sleep .7 hours has a weak but not-quite significant grant P01AG031093 and by grant #58729 from the Pioneer Portfolio of the Robert Wood Johnson Foundation; the National Longitudinal Study of Adolescent controls for age, race, ethnicity, household income, and mother’s (p = 0.08) positive effect on an individual’s sleep behavior. Health was originally funded by National Institute of Child Health and Human Development. The funders had no role in study design, data collection and analysis, education. Similarly, ego drug use in Wave II is associated with the number decision to publish, or preparation of the manuscript. In contrast, we find no significant relationship between of contacts in Wave I who use drugs, as shown in Table 2. Each centrality and drug use (see Text S1). We also considered the additional drug-using friend increases the likelihood of use by 42%
- 164. Sleep, Drugs, SocialNetworks Figure 2. Spread of sleep and drug use. Figure 2 shows that the association between ego and alter sleep is significant up to four degrees of separation in both Wave I and Wave II. The left panel shows the percentage increase in the likelihood a person sleeps #7 hours if a friend at a certain social distance sleeps #7 hours. The right panel shows the percentage increase in the likelihood a person uses marijuana if a friend at a certain social distance uses marijuana. The relationship is strongest between individuals who are directly connected, but it remains significantly greater than zero at social distances up to 4 degrees of separation in both Wave I and Wave II. Thus, a person’s sleep and drug use behavior is associated with the same behavior of other people up to 4 degrees removed from them in the network. Error bars are derived by comparing the conditional probability of the behavior in the observed network with an identical network in which topology and incidence of the behavior is preserved but the assignment of the behavior is randomly distributed [19,55 2008]. Alter social distance (degrees of separation) refers to closest social distance between the alter and ego (friend = distance 1, friend’s friend = distance 2, etc.). Error bars show 95% confidence intervals. doi:10.1371/journal.pone.0009775.g002 that suggests the negative health behavior is more contagious than change in behavior in each alter is associated with a change in the positive health behavior. behavior in the ego. The models adjust for sex, age, race, ethnicity,
- 165.
- 166. Where and howcan we correct sleep deprivation mismatch? Home? Schools? Child-care and youth serving organizations? Workplaces? Prisons and jails? Mental health and substance abuse treatment? Doctors, clinics and insurance payers? Local, state, and federal policies?
- 167. Evidence-Based Kernels for prevention,mitigation, treatment & promotion The smallest units of proven behavioral influence can be used well outside the PAX Game for reducing the burden of mental, emotional, behavioral, and related physical illnesses. Download and review at: www.pubmed.gov
- 168. Relational Antecedent Reinforcement Physiological Frame Kernel Kernel Kernel Kernel Changes Creates verbal Happens BEFORE Happens AFTER the biochemistry of relations for the the behavior behavior behavior behavior Embry, D. D., & Biglan, A. (2008). Evidence-Based Four Types of Kernels Kernels: Fundamental Units of Behavioral Influence. Clinical Child & Family Psychology Review, 39.
- 169. Kernels are building blocksof behavior change Humans survive individually and collectively by influencing the behavior or other humans The 2008 paper by Embry and Biglan identifies 52 evidence based kernels that can be used to design or or improve programs.
- 170. Secondary School Bullying andViolence Current culture creates an evolutionary mismatch during adolescence that results in violence, bullying, and antisocial behavior. Curriculum and posters do not solve the problem, and often feed the evolutionary mismatch. Could evidence-based kernels help correct the evolutionary mismatch?
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- 179. 60 Results Logan Jr. High School, Princeton, Ill. Grades 7-8 DETENTIONS Before After Kernels 50 Kernels 40 30 20 10 0 Sep-99 Oct-99 Nov-99 Dec-99 Jan-00 Feb-00 Mar-00 Apr-00 May-00 Sep-00 Oct-00 Nov-00 Dec-00 Jan-01 Feb-01 Mar-01 Apr-01
- 180. Results 6.25 Logan Jr. High School, Princeton, Ill. Grades 7-8 FIGHTING Before Kernels After Kernels 5 3.75 2.5 1.25 0 Sep-99 Oct-99 Nov-99 Dec-99 Jan-00 Feb-00 Mar-00 Apr-00 May-00 Sep-00 Oct-00 Nov-00 Dec-00 Jan-01 Feb-01 Mar-01 Apr-01
- 181. Acceptance & Commitment Therapy Kernels Relational Frame Kernel
- 182. Relational-Frame Example: “Families United Promise” Relational Frame 1 1.35 Kernel 0.9 0.8 1.3 Mean drunkenness Mean delinquency 0.7 0.6 1.25 0.5 0.4 1.2 0.3 0.2 1.15 0.1 0 1.1 grade 7 grade 8 grade 9 grade 7 grade 8 grade 9 Figure 2 Repeated-measures analysis of variance displaying self-reported drunkenness (a) and delinquency (b) separately for youths in the intervention and control conditions
- 183. Emotional writing… Relational Figure 2. Effect of Structured Writing by Disease: Asthma or Rheumatoid Arthritis Frame Control Experimental Kernel 90 Asymptomatic Asthma Forced Expiratory Volume 85 Rheumatoid Arthritis Overall Disease Activity in 1 s, % Predicted 80 Mild 75 70 Moderate 65 60 55 Severe Baseline 4-mo Follow-up Baseline 4-mo Follow-up Time Time JAMA, April 14, 1999—Vol 281, No. 14 1307
- 184. Goal Maps (visualorganized brief motivational interview) Relational Frame Kernel Cigarettes Consumed Creates verbal Alcohol Consumed relations for the behavior Marijuana Consumed
- 185. Lifespan example ofone kernel for prevention, intervention and treatment Reinforcement Kernel Happens AFTER the behavior Available from Amazon.com for $45
- 186. T6--'->!$#%81!";S0+FQT0P!+0IIF2;G!HQT!0PP! Kernels lower costof training, support & change… ! L.'(-!MC!?N.B1(-!L.'(-!3;!E-25-(!A/)()/$!;32!G-(-*/-9O!659)*./-9!.59!A5)4-27.(! %2-4-5/)35! ?4)9-5*-+D.7-9! G-(-*/-9! 659)*./-9! A5)4-27.(! E-25-(! Intervention %2-4-5/)35! Targeted %2-4-5/)35! Universal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c.! 7&11(-B-5/./)35! C()8#)*'-#!%-8Z()! (/!J.A,$(7',! ,(>-'7'&#! UJ$A.'(*(>',%*! C'J(*%)!8'.()8#)_K! #J'.(8#.!'-! J#)/()5%-,#!%-8! Y#)-#*W! T#86,#!%67'.5! J)(8)(5%*! J)#&#-7!C#$%&'()%*! .A5J7(5._@:!@LD! %8(*#.,#-7.L_! 8'.()8#).VO:!DV3DN! %&'()*!137/)5K! T#86,#!,(556-'7A! F5J)(&#!J)(C*#5%7',! T#86,#!'5J6*.'&#!()! U%-7#,#8#-7!Y#)-#*W! '**#>%*!C#$%&'().@KK:! C#$%&'()!'-! )'.YA!C#$%&'().!'-! @K@:!@DK! 7$#)%J#67',! >#-#)%*! .#77'->.DO:!DLK! J(J6*%7'(-DL@3DL! Kernels provide robustness, cost-efficiency and community sustainability across multi-problem behaviors. F5J)(! %,%8#5',.DLL3DLV! 4)(5(7'->! J%)7','J%7'(-!()! ,(556-'7A!>((8.DL_:! DLN!
- 187. Better Health Care via Proven Practices Used by Broad Workforce => Better Health via Multiple Indicators, Increased and Decreased => Better Fiscals Cost Benefits & Cost Efficiencies Lower Better Health Care Promotion Costs Better Prevention & Reduced Stronger Protection Disparties Economy Better Interventions Other Better Treatments Cost Better Offsets Recovery Implementation Monitoring of Immediate and Longer Term Sustainaibility Policies and monitoring & Outcomes with Feedback Loops Practices Implemented feedback
- 188. Create policy & funding supports TH Vaccine cacy, Identify (organizational, Recipe List local, local and/or state Adoption, Behaviors Implementation, & Reduced state and national Maintenance policies Cultivate some positively current or Identify impacted or Psychinfo prospective early Behaviors lled by www.pubmed.gov recipe adopters for ERIC Increased testimonials Lo Hi NTIS Cite relevant Evaluation & User T Cite relevant endorsements Outcome Local Impacting Values studies or standards Monitoring State National Population Targeting -A - Daily, Weekly B Developmen Birth Childhood ta l stages Low catchy positive What the or Monthly Adolescence Intensity Adulthood Hi name (meme) ts are Feedback reach Multiple Fa Sc els m ho ilie Settings o lev Or - Where/ s ga ls - What A Co ni at ach mm un ns io how to get the costs of use itie /re s C recipe are sity Recognition/Rewards en for Successs Int - Relational framing High Intensity Low reach Support & Training res
- 189. Thinking about andmeasuring recovery, relapse and recidivism Treatment Strategy #1 Treatment Strategy #2 100 100 Do these two Only 17% of the About 80% of the evidence- based discharged clients of program #1 have discharged clients of program #2 strategies look 50 50 not relapsed, been re-arrested, or “survived” with no relapse, significantly re-hospitalized by 48 months. re-arrested, or re-hospitalization by different at 20 48 months. days? 0 0 0 10 20 30 40 50 0 10 20 30 40 50 Time in Months Time in Months
- 190. Thinking about andmeasuring recovery, relapse and recidivism Treatment Strategy #1 Treatment Strategy #2 100 100 Only 17% of the About 80% of the discharged clients discharged clients of program #1 have of program #2 50 not relapsed, been 50 “survived” with re-arrested, or no relapse, re-hospitalized by re-arrested, or 48 months. re-hospitalization by 48 months. 0 0 0 10 20 30 40 50 0 10 20 30 40 50 Time in Months Time in Months
- 191. Where and howcan we spread cost efficient evidence-based kernels for… Home? Schools? Child-care and youth serving organizations? Workplaces? Prisons and jails? Mental health and substance abuse treatment? Doctors, clinics and insurance payers? Local, state, and federal policies?
- 192. B e ha v i o r a l Vac c i n e s an d Evidence-Based Kernels: Nonpharmaceutical A p p ro a c h e s f o r th e P re v e n t i o n o f M e n t a l , Emotional, and B e h a v i o r a l D i s o rd e r s Dennis D. Embry, PhD KEYWORDS Evidence-based kernels Behavioral vaccines Prevention Public health Available at: www.slideshare.net/drdennisembry
- 193. Key “good news”messages from IOM Report…
- 194. Key “good news”messages from IOM Report… MEB’s are preventable.
- 195. Key “good news”messages from IOM Report… Break-even for MEB’s are MEB preventable. prevention is 1-2 years.
- 196. Key “good news”messages from IOM Report… Break-even for MEB MEB’s are MEB prevention preventable. prevention is balances gov’t 1-2 years. budgets.
- 197. Key “good news”messages from IOM Report… Break-even for MEB MEB MEB’s are MEB prevention prevention preventable. prevention is balances gov’t reduces 1-2 years. budgets. suffering.
- 198. Key “good news”messages from IOM Report… Break-even for MEB MEB MEB’s are MEB prevention prevention preventable. prevention is balances gov’t reduces 1-2 years. budgets. suffering. Effective MEB prevention helps save Health Accord.
- 199. Key “good news”messages from IOM Report… Break-even for MEB MEB MEB’s are MEB prevention prevention preventable. prevention is balances gov’t reduces 1-2 years. budgets. suffering. Effective MEB MEB prevention prevention helps save national local Health Accord. economies.
- 200. Key “good news”messages from IOM Report… Break-even for MEB MEB MEB’s are MEB prevention prevention preventable. prevention is balances gov’t reduces 1-2 years. budgets. suffering. Effective MEB MEB prevention prevention MEB prevention helps save national local saves Old Age Security. Health Accord. economies.
- 201. Key “good news”messages from IOM Report… Break-even for MEB MEB MEB’s are MEB prevention prevention preventable. prevention is balances gov’t reduces 1-2 years. budgets. suffering. Effective MEB MEB MEB prevention prevention MEB prevention prevention helps save national local saves Old Age heals past Security. Health Accord. economies. inequities.
- 202. dde@paxis.org Dennis D. Embry, Ph.D. dde@paxis.org 520-299-6770 Business cards available for follow up and copies of papers presentations
Editor's Notes
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- #71 MISSION: READINESS\nIn a study being released Thursday Nov 5, 2009 in Washington, Education Secretary Arne Duncan and a group of retired military officers led by former Army Gen. Wesley Clark will sound the alarm bells and call young Americans&#x2019; relative lack of overall fitness for military duty a national security threat. The group, Mission: Readiness, will release a report that draws on Pentagon data showing that 75 percent of the nation&#x2019;s 17- to 24-year-olds are ineligible for service for a variety of reasons.\n\nPut another way, only 4.7 million of the 31.2 million 17- to 24-year-olds in a 2007 survey are eligible to enlist, according to a periodic survey commissioned by the Pentagon. This group includes those who have scored in the top four categories on the Armed Forces Qualification Test, or AQFT; eligible college graduates; and qualified college students.\n\nAccording to the Pentagon, the ineligible population breaks down this way:\n\n&#x2022;Medical/physical problems, 35 percent.\n&#x2022;Illegal drug use, 18 percent.\n&#x2022;Mental Category V (the lowest 10 percent of the population), 9 percent.\n&#x2022;Too many dependents under age 18, 6 percent.\n&#x2022;Criminal record, 5 percent.\n
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- #100 There are now studies showing that grades and behavior improve in school when children and teens increase their daily intake of omega-3 brain food. \n\nIn a randomized study on Durham school district in the England, children got omega-3 or placebo. During the first 3 months the average gain for children taking fatty acids was 9.5 months for reading and 6.5 months for spelling. Yes, this was very statistically significant. Notice the improvement in writing skills, as an example of change.\n\nLater the children who got the placebo received omega-3, and their results then improved.\n\n\n
- #101 When people consume lots of the omega 6s, they are 2.5 times more likely to develop depression, compared to people who consume omega-3&#x2018;s. Depression in the United States has been steadily increasing, and our young people consume the most omega-6&#x2019;s in the world.\n
- #102 When people consume lots of the omega 6s, they are 2.5 times more likely to develop depression, compared to people who consume omega-3&#x2018;s. Depression in the United States has been steadily increasing, and our young people consume the most omega-6&#x2019;s in the world.\n
- #103 When people consume lots of the omega 6s, they are 2.5 times more likely to develop depression, compared to people who consume omega-3&#x2018;s. Depression in the United States has been steadily increasing, and our young people consume the most omega-6&#x2019;s in the world.\n
- #104 When people consume lots of the omega 6s, they are 2.5 times more likely to develop depression, compared to people who consume omega-3&#x2018;s. Depression in the United States has been steadily increasing, and our young people consume the most omega-6&#x2019;s in the world.\n
- #105 When people consume lots of the omega 6s, they are 2.5 times more likely to develop depression, compared to people who consume omega-3&#x2018;s. Depression in the United States has been steadily increasing, and our young people consume the most omega-6&#x2019;s in the world.\n
- #106 Too much omega 6&#x2014;the bad brain food&#x2014;hurts intelligence and school performance. American children have the highest levels of omega-6 in the world, and countries like Japan have the lowest level. And which country has children scoring high on standardized achievement tests?\n
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- #116 Explain:\n\nBilly&#x2019;s behavior can be predicted by a mathematical formula&#x2014;just like many things in nature can be predicted by a formula. The formula is simple just like E=MC2 by Einstein is simple&#x2014;though powerful and complex in many ways.\n
- #117 So here is our estimate of the frequency of reinforcement for PAX and the reinforcement of Spleems. What does that mean for the amount of PAX time wherein the conditions of teaching and learning favor success?\n
- #118 And the answer?\n
- #119 The question is how to solve the situation. \n
- #120 The question is how to solve the situation. \n
- #121 The question is how to solve the situation. \n
- #122 The question is how to solve the situation. \n
- #123 The question is how to solve the situation. \n
- #124 The question is how to solve the situation. \n
- #125 The question is how to solve the situation. \n
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- #168 Preventing Sleep Deprivation\nThe IOM Report (IOM, page 212) points out that there is a need for a public campaign to increase healthy sleep among the nation&#x2019;s children and youth to prevent mental, emotional and behavioral disorders&#x2014;including risk of addictions.1-4 Good sleep also reduces obesity in children and young adults.5-7\nSleep deprivation is rapidly increasing in children and teens&#x2014;by virtue of electronic media (e.g., cellphones, instant messaging, TV&#x2019;s and electronic games in children&#x2019;s bedrooms) is now firmly linked to increased risk of ATOD use and other problematic behaviors for multiple biological, media modeling, and adverse norming reasons.\nOur children today sleep a lot less than children just 10-20 years ago. The lack of sleep, even as a young child, significantly predicts getting drunk, stoned, or in trouble with the law including for violence as well as doing poorly in school.4 8-11 The reason is not more homework or family stress. The reason is simple: Children&#x2019;s bedrooms today are like electronic super-stores&#x2014;often with a TV, a computer, electronic games, and now cell phones.10 12-20 These electronic things are a lot more exciting and sleep depriving than reading a book under the covers with a flashlight.20 When parents significantly reduce use of these things&#x2014;especially in children&#x2019;s bedrooms&#x2014;children and teens are healthier, less irritable, do better in school and less likely to get into all manner of trouble.21 22 There are some strategies to slim your child&#x2019;s media diet if families are unsure what to do.23\nBibliography\n1. Abe T, Hagihara A, Nobutomo K. Sleep patterns and impulse control among Japanese junior high school students. J Adolesc 2009.2. Holm SM, Forbes EE, Ryan ND, Phillips ML, Tarr JA, Dahl RE. Reward-related brain function and sleep in pre/early pubertal and mid/late pubertal adolescents. Journal of Adolescent Health 2009;45(4):326-34.3. Wong CJ, Sheppard J-M, Dallery J, Bedient G, Robles E, Svikis D, et al. Effects of reinforcer magnitude on data-entry productivity in chronically unemployed drug abusers participating in a therapeutic workplace. Experimental & Clinical Psychopharmacology 2003;11(1):46-55.4. Wong MM, Brower KJ, Fitzgerald HE, Zucker RA. Sleep problems in early childhood and early onset of alcohol and other drug use in adolescence. Alcoholism: Clinical & Experimental Research 2004;28(4):578-87.5. Nielsen LS, Danielsen KV, Sorensen TI. Short sleep duration as a possible cause of obesity: critical analysis of the epidemiological evidence. Obes Rev 2010.6. Cappuccio FP, Taggart FM, Kandala NB, Currie A, Peile E, Stranges S, et al. Meta-analysis of short sleep duration and obesity in children and adults. Sleep 2008;31(5):619-26.7. Al Mamun A, Lawlor DA, Cramb S, O'Callaghan M, Williams G, Najman J. Do childhood sleeping problems predict obesity in young adulthood? Evidence from a prospective birth cohort study. Am J Epidemiol 2007;166(12):1368-73.8. Chervin RD, Dillon JE, Archbold KH, Ruzicka DL. Conduct problems and symptoms of sleep disorders in children. Journal of the American Academy of Child & Adolescent Psychiatry 2003;42(2):201-08.9. Owens J, Maxim R, McGuinn M, Nobile C, Msall M, Alario A. Television-viewing habits and sleep disturbance in school children. Pediatrics 1999;104(3):e27.10. Dworak M, Schierl T, Bruns T, Str&#xB8;der HK. Impact of singular excessive computer game and television exposure on sleep patterns and memory performance of school-aged children. Pediatrics 2007;120(5):978-85.11. Meijer AM. Chronic sleep reduction, functioning at school and school achievement in preadolescents. Journal of Sleep Research 2008;17(4):395-405.12. Van den Bulck J. Television viewing, computer game playing, and Internet use and self-reported time to bed and time out of bed in secondary-school children.[see comment]. Sleep 2004;27(1):101-4.13. Van den Bulck J. Text messaging as a cause of sleep interruption in adolescents, evidence from a cross-sectional study. Journal of Sleep Research 2003;12(3):263-63.14. Tazawa Y, Okada K. Physical signs associated with excessive television-game playing and sleep deprivation. Pediatrics International 2001;43(6):647-50.15. Johnson JG, Cohen P, Kasen S, First MB, Brook JS. Association between television viewing and sleep problems during adolescence and early adulthood.[see comment]. Archives of Pediatrics & Adolescent Medicine 2004;158(6):562-8.16. Thompson DA, Christakis DA. The association between television viewing and irregular sleep schedules among children less than 3 years of age. Pediatrics 2005;116(4):851-6.17. Paavonen EJ, Pennonen M, Roine M, Valkonen S, Lahikainen AR. TV exposure associated with sleep disturbances in 5- to 6-year-old children. Journal of Sleep Research 2006;15(2):154-61.18. Toyran M, Ozmert E, Yurdakok K. Television viewing and its effect on physical health of schoolage children. Turkish Journal of Pediatrics 2002;44(3):194-203.19. Borzekowski DLG, Robinson TN. The Remote, the Mouse, and the No. 2 Pencil: The Household Media Environment and Academic Achievement Among Third Grade Students. Arch Pediatr Adolesc Med 2005;159(7):607-13.20. Suganuma N, Kikuchi T, Yanagi K, Yamamura S, Morishima H, Adachi H, et al. Using electronic media before sleep can curtail sleep time and result in self-perceived insufficient sleep. Sleep and Biological Rhythms 2007;5(3):204-14.21. Barkin SL, Finch SA, Ip EH, Scheindlin B, Craig JA, Steffes J, et al. Is Office-Based Counseling About Media Use, Timeouts, and Firearm Storage Effective? Results From a Cluster-Randomized, Controlled Trial. Pediatrics 2008;122(1):e15-25.22. Gorin A, Raynor H, Chula-Maguire K, Wing R. Decreasing household television time: A pilot study of a combined behavioral and environmental intervention. Behavioral Interventions 2006;21(4):273-80.23. Jordan AB, Hersey JC, McDivitt JA, Heitzler CD. Reducing Children's Television-Viewing Time: A Qualitative Study of Parents and Their Children. Pediatrics 2006;118(5):e1303-10.\n
- #169 Sleep deprivation is particularly a problem for children. In studies of elementary aged children, nearly 40% had some type of sleep problem, 15% exhibited bedtime resistance and 10% had daytime sleepiness. Nearly half of teens reported at least occasional difficulty in falling or staying asleep and almost 13% experiencing chronic and severe insomnia. This lack of sleep greatly affects mood, behavior, and academic performance. In pediatric research, poor sleepers reported being significantly more depressed and were even more likely to have a negative self-image. They were also more likely to exhibit negative behavior patterns and inferior coping behaviors and have more behavioral problems at home and in school. One study showed that students that students with C&#x2019;s, D&#x2019;s and F&#x2019;s went to bed an average of 40 minutes later and got 20 minutes less sleep than A students. Insufficient sleep has also been associated with Attention Deficit Hyperactivity Disorder (ADHD), lower social skills and learning difficulties.\n
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- #173 Here is one example of an experimental study to reduce TV and electronic media.\n\nRobinson, T. N., M. L. Wilde, et al. (2001). "Effects of reducing children's television and video game use on aggressive behavior: a randomized controlled trial.[see comment]." Archives of Pediatrics & Adolescent Medicine 155(1): 17-23.CONTEXT: The relationship between exposure to aggression in the media and children's aggressive behavior is well documented. However, few potential solutions have been evaluated. OBJECTIVE: To assess the effects of reducing television, videotape, and video game use on aggressive behavior and perceptions of a mean and scary world. DESIGN: Randomized, controlled, school-based trial. \nSETTING: Two sociodemographically and scholastically matched public elementary schools in San Jose, Calif. PARTICIPANTS: Third- and fourth-grade students (mean age, 8.9 years) and their parents or guardians. \nINTERVENTION: Children in one elementary school received an 18-lesson, 6-month classroom curriculum to reduce television, videotape, and video game use. MAIN OUTCOME MEASURES: In September (preintervention) and April (postintervention) of a single school year, children rated their peers' aggressive behavior and reported their perceptions of the world as a mean and scary place. A 60% random sample of children were observed for physical and verbal aggression on the playground. Parents were interviewed by telephone and reported aggressive and delinquent behaviors on the child behavior checklist. The primary outcome measure was peer ratings of aggressive behavior. \nRESULTS: Compared with controls, children in the intervention group had statistically significant decreases in peer ratings of aggression (adjusted mean difference, -2.4%; 95% confidence interval [CI], -4.6 to -0.2; P =.03) and observed verbal aggression (adjusted mean difference, -0.10 act per minute per child; 95% CI, -0.18 to -0.03; P =.01). Differences in observed physical aggression, parent reports of aggressive behavior, and perceptions of a mean and scary world were not statistically significant but favored the intervention group. CONCLUSIONS: An intervention to reduce television, videotape, and video game use decreases aggressive behavior in elementary schoolchildren. These findings support the causal influences of these media on aggression and the potential benefits of reducing children's media use.\n
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