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New Hope for Cancertherapy:  A New Drug  Combination for  Chemoimmunotherapy ,[object Object]
Company Overview ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Business Focus ,[object Object],[object Object],[object Object],[object Object],[object Object],New applications of approved drugs  Targeted Therapy:  physical  & molecular targets  Combination Therapy:  chemoimmunotherapy Personalized Cancer Therapy
[object Object],[object Object],TriCancerVac ,[object Object],[object Object],[object Object],Adjuvant Increasing immunogenicity of tumor antigens to boost immune response Oxidant  Controlling drug-release
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Technology Goldberg  2002  Intratumoral cancer chemotherapy and immunotherapy: opportunities for nonsystemic preoperative drug delivery . J Pharm Pharmacol. 54:159-80
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Technology
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Technology Emens LA. 2008.  Chemotherapy and tumor immunity: an unexpected collaboration.   Front Biosci. 13: 249-57. Lake RA. 2005.  Immunotherapy and chemotherapy--a practical partnership.  Nat Rev Cancer. 5(5): 397-405. Nowak AK. 2006.  Combined chemoimmunotherapy of solid tumours: improving vaccines?   Adv Drug Deliv Rev. 58:975-90.
Competitive Advantage ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Local  Chemotherapy Personalized Cancer Therapy Systemic  Immunity +
[object Object],Clinical Data   —  Liver Cancer Stage N Median Survival Time (M) Six Month Survival Rate ( % )  One Year Survival Rate ( % ) - Adjuvant Ⅱ 2 2 50 50 Ⅲ 31 4 41.94 29.03 Ⅳ 57 3 24.56 10.53 Sum 90 3.5 32.22 18.89 + Adjuvant Ⅱ 7 30.1 85.71 71.42 Ⅲ 86 7 70.93 31.39 Ⅳ 116 5.5 52.58 25.86 Sum 209 7 61.24 29.67
Clinical Data   Pancreatic Cancer Group N Six Month Survival Rate (%) p One Year Survival Rate ( % ) p +Adjuvant 25 64 > 0.05 28 < 0.05 -Adjuvant 20 45 5
Clinical Data   —  NSCLC* *Patients were treated with intratumoral therapy, followed by supportive treatment  (radiotherapy and EP Chemotherapy : CBP 0.3 d 1 , VP-16 0.1 d 1 ~ 4 ) Group Stage N Median Survival Time (M) Six Month Survival  Rate (%) One Year Survival Rate (%) - Adjuvant II 10 6.33 50 30 III 20 5.52 45 20 IV 12 4.9 41.67 33.33 Sum 42 7.59 45.23 26.19 + Adjuvant II 8 11.47 100 50 III 33 11.9 69.7 42.42 IV 11 9.77 81.82 45.45 Sum 52 12.66 76.36 45.45
Clinical Data   —  NSCLC** **Patients were treated with intratumoral therapy alone Group N Mean Survival Time (M) Median Survival Time (M) Six Month Survival Rate ( % )  One Year  Survival  Rate ( % ) -Adjuvant Ⅰ 2 22.5 4 50 50 Ⅱ 2 4.5 4.5 0 0 Ⅲ 6 3.33 2 16.67 0 Ⅳ 4 6.15 4.5 50 25 Sum 14 7.04 3.5 28.57 14.29 +Adjuvant Ⅰ 5 25.5 13 60 60 Ⅱ 2 14 11 50 50 Ⅲ 11 18.8 10 72.72 45.45 Ⅳ 7 2.86 1 28.57 0 Sum 25 15.29 9 64 36
Clinical Data     Relapsed   NSCLC Patients were treated with intratumoral therapy, followed by supportive treatment Group N Mean Survival Time (M) Median Survival Time (M) One Year Survival  Rate (% ) -Adjuvant 34 7.40 5.32 5.88 +Adjuvant 60 11.99 9.36 20.34
[object Object],Clinical Data   —  Tumor Response
Clinical Data Side Effect Evaluation  SE Sum N ï¼… â…  â…¡ â…¢ â…£ Nausea/Vomit 120 6 6 0 0 10 Hair Loss 120 0 0 0 0 0 Leukopenia 120 2 1 1 0 3.33
Applications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
IP Status Australia  AU60177024 United States  US6811788 China  ZL01806830.8
D IND D P C A B ARA-C-T ADM-T E = Exploratory Clinical Testing   E Automatic Injector GEMCITABINE-T PTX-T
Partnership ,[object Object],[object Object],[object Object],[object Object],[object Object]
World Is Smaller  Here
[object Object],Thank You www.bfyl.com

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New Hope for Cancertherapy

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  • 10. Clinical Data Pancreatic Cancer Group N Six Month Survival Rate (%) p One Year Survival Rate ( ï¼… ) p +Adjuvant 25 64 > 0.05 28 < 0.05 -Adjuvant 20 45 5
  • 11. Clinical Data — NSCLC* *Patients were treated with intratumoral therapy, followed by supportive treatment (radiotherapy and EP Chemotherapy : CBP 0.3 d 1 , VP-16 0.1 d 1 ~ 4 ) Group Stage N Median Survival Time (M) Six Month Survival Rate (%) One Year Survival Rate (%) - Adjuvant II 10 6.33 50 30 III 20 5.52 45 20 IV 12 4.9 41.67 33.33 Sum 42 7.59 45.23 26.19 + Adjuvant II 8 11.47 100 50 III 33 11.9 69.7 42.42 IV 11 9.77 81.82 45.45 Sum 52 12.66 76.36 45.45
  • 12. Clinical Data — NSCLC** **Patients were treated with intratumoral therapy alone Group N Mean Survival Time (M) Median Survival Time (M) Six Month Survival Rate ( ï¼… ) One Year Survival Rate ( ï¼… ) -Adjuvant â…  2 22.5 4 50 50 â…¡ 2 4.5 4.5 0 0 â…¢ 6 3.33 2 16.67 0 â…£ 4 6.15 4.5 50 25 Sum 14 7.04 3.5 28.57 14.29 +Adjuvant â…  5 25.5 13 60 60 â…¡ 2 14 11 50 50 â…¢ 11 18.8 10 72.72 45.45 â…£ 7 2.86 1 28.57 0 Sum 25 15.29 9 64 36
  • 13. Clinical Data Relapsed NSCLC Patients were treated with intratumoral therapy, followed by supportive treatment Group N Mean Survival Time (M) Median Survival Time (M) One Year Survival Rate (% ) -Adjuvant 34 7.40 5.32 5.88 +Adjuvant 60 11.99 9.36 20.34
  • 14.
  • 15. Clinical Data Side Effect Evaluation SE Sum N ï¼… â…  â…¡ â…¢ â…£ Nausea/Vomit 120 6 6 0 0 10 Hair Loss 120 0 0 0 0 0 Leukopenia 120 2 1 1 0 3.33
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  • 17. IP Status Australia AU60177024 United States US6811788 China ZL01806830.8
  • 18. D IND D P C A B ARA-C-T ADM-T E = Exploratory Clinical Testing E Automatic Injector GEMCITABINE-T PTX-T
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