1. Pathology-LabNeoplasia-127th Oct’09 Ravi A Patel

2. Memory++ (M++) Villous adenoma Colon Lipoma Leiomyoma Fibro adenoma Verruca vulgaris (warts) - Skin

3. Normal Colon Taenia coli Normal Rectum 3.Tunica Muscularis outer longitudinal inner circular 2.Submucosa 1.Mucosa

4. While Observing the slide of Villous Adenoma Epithelial Polyp- (Abnormal growth of tissue from the mucous membrane) Generally Sessile- upto 10cm diameter,velvety, cauliflower like projections 1-3 cm above normal mucosa The Frondlike(large divided leaf like) villiforms are surrounded by Dyplastic,disorderly arranged columnar epithelium Site of Adenoma- Colon, Rectum and Rectosigmoid

5. Villous Adenoma Epithelial Polyp Dysplastic Columnar Epithelium

6. Villous Adenoma Branching of the glands Scanty fibrous stroma between the glands

7. While observing slide of Lipoma Tumor Fibrous capsule Remnants of the lobules Mature fat cells Scanty Stroma

8. Fat cells are Within a thin fibrous capsule Mature Fat cells with Scanty stroma Remnants Of mammary Gland lobules Lipoma LPO

9. LPO

10. HPO Fibrous capsule

11. HPO Scanty stroma and Fat cells

13. Underlying Dermis shows scanty lymphocyte infiltrates

14. Causative organism-HPVCentral thickened portion----- Represents Epidermal Hyperplasia with Papillomatous formation

15. Structure at pointer :- Papillomatous formation LPO Verruca Vulgaris Skin (Warts)

16. Koilocytes Structure at pointer- Koilocyte with Halos Surrounding the nuclei HPO

17. Koilocytes HPO

18. Obvious transition representing the further central thickened portion to follow which signifies the site of Wart LPO

19. Another view of centally thickened portion with Papillomatous formation

20. Scanty Lymphocyte infiltrates in the Dermis

21. While Observing the slide of Leiomyoma– A.K.A Fibroids In HPO- Observe the whorling of the smooth muscles of the myometrium Fibrosis of the stroma is found. Also Known as Fibroids because they are firm. Facts– Leiomyoma is the most common benign tumour in women and they arise from smooth muscle of myometrium. They occur during active reproductive life.In Menopause they may calcify.Estrogen stimulate their Growth.

22. HPO Leiomyoma Whorling of smooth muscles Of myometrium

23. HPO

24. LPO Significant Fibrosis

25. While observing the slide of Fibroadenoma Proliferating intralobular stroma pushing the epithelium There are 2 types of fibroadenoma PericanalicularFibroadenoma In this kind of Fibroadenoma the ductal space are round/oval and fairly regualar 2. IntracanalicularFibroadenoma Over here there is extensive proliferation of surrounding stroma which compresses the ducts giving them irregular/star shape on cross section.

26. Poliferating Stroma is pushing The ducts leading to their irregular Shape.. This signifies of the slide being Intracanalicularfibradenoma Fibroadenoma

27. Thanking to the entire Universe