NBO -Dobelle implant

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A French team led by Marie Mbelek is evaluating the Dobelle implant to restore vision. The document discusses blindness worldwide and in the US, where the main causes are cataracts and glaucoma. It provides a general presentation of the Dobelle implant, which uses a CCD camera and microelectrodes on the visual cortex. Potential limits of the device are also mentioned.

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Dobelle implant project
French team
Marie Mbelek, Chair woman
Yéléna Blacodon, Doctor
Océane Lair, Sociologist
Caroline Serra, Phisicist

11/03/2012 NBO - French team - Dobelle Implant

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11/03/2012 NBO - French team - Dobelle Implant

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11/03/2012 NBO - French team - Dobelle Implant

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1 - WEIGHT OF THE BLINDNESS IN THE UNITED STATES

Worldwide - 7 Milliards
visually impaired : 161 million
low vision :124 million
blind : 37 million. USA - 313 Million
visually impaired : 10 million
blind : between 1 and 2 million

Economic impact of blindness in USA
4,1 billion/year
11 000 $ per blind/year

11/03/2012 NBO - French team - Dobelle Implant

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1 - WEIGHT OF THE BLINDNESS IN THE UNITED STATES

11/03/2012 NBO - French team - Dobelle Implant

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2 - PRINCIPAL CAUSES OF BLINDNESS
HUMAN EYE

11/03/2012 NBO - French team - Dobelle Implant

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2 - PRINCIPAL CAUSES OF BLINDNESS
CATARACT

11/03/2012 NBO - French team - Dobelle Implant

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2 - PRINCIPAL CAUSES OF BLINDNESS
GLAUCOMA

11/03/2012 NBO - French team - Dobelle Implant

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3. GENERAL PRESENTATION OF THE DEVICE

11/03/2012 NBO - French team - Dobelle Implant

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4 – FUNCTIONING OF THE CDD CAMERA

11/03/2012 NBO - French team - Dobelle Implant

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5. LIMITS OF THE DEVICE

11/03/2012 NBO - French team - Dobelle Implant

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11/03/2012 NBO - French team - Dobelle Implant

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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).

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NBO -Dobelle implant

1. 1 Dobelle implant project French team Marie Mbelek, Chair woman Yéléna Blacodon, Doctor Océane Lair, Sociologist Caroline Serra, Phisicist 11/03/2012 NBO - French team - Dobelle Implant

2. 2 11/03/2012 NBO - French team - Dobelle Implant

3. 3 11/03/2012 NBO - French team - Dobelle Implant

4. 4 1 - WEIGHT OF THE BLINDNESS IN THE UNITED STATES Worldwide - 7 Milliards visually impaired : 161 million low vision :124 million blind : 37 million. USA - 313 Million visually impaired : 10 million blind : between 1 and 2 million Economic impact of blindness in USA 4,1 billion/year 11 000 $ per blind/year 11/03/2012 NBO - French team - Dobelle Implant

5. 5 1 - WEIGHT OF THE BLINDNESS IN THE UNITED STATES 11/03/2012 NBO - French team - Dobelle Implant

6. 6 2 - PRINCIPAL CAUSES OF BLINDNESS HUMAN EYE 11/03/2012 NBO - French team - Dobelle Implant

7. 7 2 - PRINCIPAL CAUSES OF BLINDNESS CATARACT 11/03/2012 NBO - French team - Dobelle Implant

8. 8 2 - PRINCIPAL CAUSES OF BLINDNESS GLAUCOMA 11/03/2012 NBO - French team - Dobelle Implant

9. 9 3. GENERAL PRESENTATION OF THE DEVICE 11/03/2012 NBO - French team - Dobelle Implant

10. 10 4 – FUNCTIONING OF THE CDD CAMERA 11/03/2012 NBO - French team - Dobelle Implant

11. 11 5. LIMITS OF THE DEVICE 11/03/2012 NBO - French team - Dobelle Implant

12. 12 11/03/2012 NBO - French team - Dobelle Implant

NBO -Dobelle implant

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