The document presents a blueprint for establishing National Nanosafety Centers (NNCs). It discusses what nanosafety is and why NNCs are needed given the growth of the nanotechnology market. It outlines the methodology used to develop the blueprint, which included an online survey of 16 existing NNCs and a workshop. The results of the survey are presented on organization structure, objectives, services, knowledge dissemination, networks, and clientele of NNCs. Conclusions provide guidelines for countries looking to establish their own NNC. The document ends by discussing the need for an NNC in Colombia specifically, given its growing nanotechnology sector.