We present the use of silver nanoparticles (AgNPs) for 3 the treatment of Diabetic Foot Ulcers (DFU) of grade 2 and 3 of Wagner classification. 1.2. Methods: Ulcers were daily treated by topical administration of AgNPs (at 1.8mg/mL of metallic silver) in addition to conventional antibiotics.
ABSTRACT- The treatment of carbuncle is early administration of antibiotics and surgery. The commonest surgical approach is Saucerization and Incision & Drainage (I&D). Two cases are presented here, one underwent Saucerization and then primary split thickness skin grafting. Another un-derwent I&D for her carbuncle. They were followed up for 8 weeks to assess their outcome. Saucerization produced the shortest length of hospital stay while I&D resulted in shortest wound healing. As a new modality of treatment now-a-days two new modalities gaining popularity for better cosmetic purpose: primary split thickness skin grafting & transposition of local skin/musculocutaneous flap.
Keywords: carbuncle, surgery, good glycemic control
This document reviews potential treatment options for COVID-19 that are supported by early evidence. It summarizes in vitro and clinical evidence for remdesivir, chloroquine/hydroxychloroquine, and lopinavir/ritonavir. Remdesivir shows potent activity against SARS-CoV-2 and other coronaviruses in vitro and clinical benefit in animal studies of MERS and Ebola. Early clinical data in COVID-19 patients treated with remdesivir showed improvement. Chloroquine also has in vitro activity against SARS-CoV-2 and is supported by some clinical case studies from China. However, the efficacy of these agents specifically for COVID-19 treatment requires further evaluation in controlled
The need of clinical intervention by pharmacists in a post surgical scenerio ...SriramNagarajan17
This document summarizes a case study on a 33-year old male patient who underwent an appendectomy surgery but developed postoperative complications. Due to mismanagement in the postoperative care, the patient's condition declined and he developed Fournier's gangrene. The case study evaluated the flaws in the treatment and justified the need for a clinical pharmacist in the surgical intensive care unit. It was concluded that having a pharmacist involved could help improve clinical outcomes, ensure safe and effective medication use, prevent overprescribing of drugs, and reduce healthcare costs.
- The study evaluated the impact of molecular iodine (I2) supplementation in two doxorubicin (DOX) chemotherapy regimens for treating canine mammary cancer.
- The standard regimen (sDOX) involved 4 cycles of DOX every 21 days by 20-minute infusion, while the modified regimen (mDOX) used 4 cycles every 15 days by 60-minute infusion. Dogs received daily I2 or placebo throughout treatment.
- Results found the mDOX regimen attenuated adverse effects compared to sDOX. I2 supplementation in mDOX decreased tumor invasion markers, increased differentiation markers, and led to higher disease-free survival rates compared to other groups.
Kits for modulation of anti-rejection therapies and early detection of neurod...Toscana Open Research
The patented technology is a nanofunctionalized device that enables the quantitative determination of the FKBP12 protein biomarker involved in many diseases. Quantification of FKBP12 in the blood allows for efficient monitoring of transplant patients and modulation of anti-rejection therapies, as well as early detection of neurodegenerative diseases. The device fills a gap by offering simple, sensitive quantification of FKBP12 directly in clinical settings. This supports proper dosing of immunosuppressive drugs for transplant patients and those with autoimmune diseases. It also enables early diagnosis of neurodegenerative conditions from easily obtained samples.
This document summarizes a study on surgical site infections (SSIs) following elective general surgery cases. The study aimed to identify the incidence and risk factors of SSIs, common causative organisms, and antibiotic sensitivity patterns. The overall SSI rate was 4.57%. The most common type of SSI was superficial infections. Staphylococcus aureus was the most commonly isolated organism. Antibiotics like linezolid, amikacin and cefotaxim were generally effective. SSIs increased hospital stay by an average of 10 days and posed significant morbidity.
This meta-analysis evaluated the effectiveness of bevacizumab (Avastin) treatment on corneal neovascularization (NV) based on 7 clinical human studies and 18 animal studies. The results showed that bevacizumab significantly reduced the area of corneal NV in both human and animal studies. Specifically, bevacizumab reduced the neovascularized area in human studies by an average of 36% overall, with 32% reduction for subconjunctival injections and 48% for topical treatment. Bevacizumab also improved best-corrected visual acuity in human studies. In animal studies, bevacizumab significantly reduced the area of corneal NV compared to controls.
ABSTRACT- The treatment of carbuncle is early administration of antibiotics and surgery. The commonest surgical approach is Saucerization and Incision & Drainage (I&D). Two cases are presented here, one underwent Saucerization and then primary split thickness skin grafting. Another un-derwent I&D for her carbuncle. They were followed up for 8 weeks to assess their outcome. Saucerization produced the shortest length of hospital stay while I&D resulted in shortest wound healing. As a new modality of treatment now-a-days two new modalities gaining popularity for better cosmetic purpose: primary split thickness skin grafting & transposition of local skin/musculocutaneous flap.
Keywords: carbuncle, surgery, good glycemic control
This document reviews potential treatment options for COVID-19 that are supported by early evidence. It summarizes in vitro and clinical evidence for remdesivir, chloroquine/hydroxychloroquine, and lopinavir/ritonavir. Remdesivir shows potent activity against SARS-CoV-2 and other coronaviruses in vitro and clinical benefit in animal studies of MERS and Ebola. Early clinical data in COVID-19 patients treated with remdesivir showed improvement. Chloroquine also has in vitro activity against SARS-CoV-2 and is supported by some clinical case studies from China. However, the efficacy of these agents specifically for COVID-19 treatment requires further evaluation in controlled
The need of clinical intervention by pharmacists in a post surgical scenerio ...SriramNagarajan17
This document summarizes a case study on a 33-year old male patient who underwent an appendectomy surgery but developed postoperative complications. Due to mismanagement in the postoperative care, the patient's condition declined and he developed Fournier's gangrene. The case study evaluated the flaws in the treatment and justified the need for a clinical pharmacist in the surgical intensive care unit. It was concluded that having a pharmacist involved could help improve clinical outcomes, ensure safe and effective medication use, prevent overprescribing of drugs, and reduce healthcare costs.
- The study evaluated the impact of molecular iodine (I2) supplementation in two doxorubicin (DOX) chemotherapy regimens for treating canine mammary cancer.
- The standard regimen (sDOX) involved 4 cycles of DOX every 21 days by 20-minute infusion, while the modified regimen (mDOX) used 4 cycles every 15 days by 60-minute infusion. Dogs received daily I2 or placebo throughout treatment.
- Results found the mDOX regimen attenuated adverse effects compared to sDOX. I2 supplementation in mDOX decreased tumor invasion markers, increased differentiation markers, and led to higher disease-free survival rates compared to other groups.
Kits for modulation of anti-rejection therapies and early detection of neurod...Toscana Open Research
The patented technology is a nanofunctionalized device that enables the quantitative determination of the FKBP12 protein biomarker involved in many diseases. Quantification of FKBP12 in the blood allows for efficient monitoring of transplant patients and modulation of anti-rejection therapies, as well as early detection of neurodegenerative diseases. The device fills a gap by offering simple, sensitive quantification of FKBP12 directly in clinical settings. This supports proper dosing of immunosuppressive drugs for transplant patients and those with autoimmune diseases. It also enables early diagnosis of neurodegenerative conditions from easily obtained samples.
This document summarizes a study on surgical site infections (SSIs) following elective general surgery cases. The study aimed to identify the incidence and risk factors of SSIs, common causative organisms, and antibiotic sensitivity patterns. The overall SSI rate was 4.57%. The most common type of SSI was superficial infections. Staphylococcus aureus was the most commonly isolated organism. Antibiotics like linezolid, amikacin and cefotaxim were generally effective. SSIs increased hospital stay by an average of 10 days and posed significant morbidity.
This meta-analysis evaluated the effectiveness of bevacizumab (Avastin) treatment on corneal neovascularization (NV) based on 7 clinical human studies and 18 animal studies. The results showed that bevacizumab significantly reduced the area of corneal NV in both human and animal studies. Specifically, bevacizumab reduced the neovascularized area in human studies by an average of 36% overall, with 32% reduction for subconjunctival injections and 48% for topical treatment. Bevacizumab also improved best-corrected visual acuity in human studies. In animal studies, bevacizumab significantly reduced the area of corneal NV compared to controls.
Nanoparticles as a novel and promising antiviral platform in veterinary medicineAhmed Hasham
Traditional veterinary virus vaccines, such as inactivated and live-attenuated vaccines, have achieved tremendous success
in controlling many viral diseases of livestock and chickens worldwide. However, many recent viral outbreaks caused by
diferent emerging and re-emerging viruses continue to be reported annually worldwide. It is therefore necessary to develop
new control regimens. Nanoparticle research has received considerable attention in the last two decades as a promising
platform with signifcant success in veterinary medicine, replacing traditional viral vector vaccines. However, the feld of
nanoparticle applications is still in its initial phase of growth. Here, we discuss various preparation methods, characteristics,
physical properties, antiviral efects, and pharmacokinetics of well-developed nanoparticles and the potential of nanoparticles
or nano-vaccines as a promising antiviral platform for veterinary medicine.
A cohort study evaluated the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on older COVID-19 patients. 17 patients received DMB and 26 did not. Significantly fewer DMB patients required oxygen therapy (17.6% vs 61.5%). DMB exposure was associated with reduced odds of oxygen therapy need and intensive care support. The study supports larger trials to determine if DMB can ameliorate COVID-19 severity through immunomodulation.
This study evaluated the efficacy and safety of intravenous injection of Mycobacterium w (Mw) in treating gram-negative sepsis.
The study involved 30 patients over 18 years of age with gram-negative sepsis and single organ dysfunction. Patients received intravenous Mw injections in addition to standard care. Results showed significant improvements in vital signs, organ function markers, and sepsis severity scores from day 2 onward compared to baseline. No major adverse events occurred.
The study concluded that intravenous Mw appears to be a well-tolerated and effective adjuvant treatment for gram-negative sepsis when added to standard care, as demonstrated by improved clinical outcomes. However, larger randomized controlled trials are still needed to confirm these findings.
This document summarizes clinical data from 53 patients with severe Covid-19 who were treated with the investigational antiviral remdesivir through a compassionate use program. Key findings include:
- 68% (36 patients) showed improvement in oxygen support needs, including 57% of those on mechanical ventilation being extubated.
- 47% (25 patients) were discharged from the hospital, and 13% (7 patients) died, with a higher mortality among those receiving invasive ventilation.
- Remdesivir appeared to have a favorable safety profile based on previous experience in Ebola patients, though efficacy will need to be determined through ongoing randomized controlled trials.
This survey aimed to assess clinicians' use of stereotactic radiotherapy and targeted therapies for metastatic renal cell carcinoma and determine support for future clinical trials. The primary objective was to evaluate the proportion of clinicians using radiotherapy for metastatic renal cell carcinoma. Secondary objectives included evaluating the proportion using targeted therapies and radiotherapy simultaneously, stopping targeted therapies for radiotherapy, and supporting further research. The online survey was distributed to members of urology and oncology groups in Australia and New Zealand to collect data on current practices. Results and conclusions will be presented at an upcoming conference.
nanobiotechnology, achievements and development prospectsYULIU384426
Nanobiotechnology has significant applications in fields like medicine, imaging, and drug delivery. It has been used to develop tools for intelligent drug delivery, gene therapy, biosensors, diagnostics, and biomaterials. Some key achievements include using nanoparticles for more precise disease detection, developing techniques to detect genetic sequences, creating protein chips to study proteomics, and developing systems to sort rare cells. Nanobiotechnology also shows promise for targeted drug delivery, gene delivery without viruses, using liposomes to cross cell membranes, engineering surfaces at the nanoscale, and streamlining the drug development process. Its future applications could include more precise diagnosis and regenerative medicine through technologies like nanosensors and nanomedicine. Continued development may help improve
This document summarizes a study that developed a CT-based radiomics score to noninvasively evaluate the tumor immune microenvironment (TIME) in 2272 gastric cancer patients. The radiomics score achieved good performance in predicting the neutrophil-to-lymphocyte ratio (NLR) status in the TIME. Notably, the radiomics score was comparable to the immunohistochemistry-derived NLR status in predicting patient survival outcomes. Furthermore, the study found that objective response rates to anti-PD-1 immunotherapy were significantly higher in patients with a low radiomics score compared to those with a high radiomics score. The radiomics imaging biomarker provides a noninvasive method for evaluating the TIME and its correlation with prognosis and response to
Short-term improvement of clinical parameters and microbial diversity in peri...M ALTAMIMI
Indocyanine green-based antimicrobial photodynamic therapy as an adjunct to scaling and root planing resulted in significantly greater reductions in periodontal pocket depth and clinical attachment loss compared to scaling and root planing alone. Microbiome analysis showed a reduction in key periodontal pathogens like Porphyromonas gingivalis and favorable shifts in the subgingival microbiome with the addition of photodynamic therapy. The combination treatment led to significantly greater short-term clinical improvements and microbial changes associated with periodontal healing.
A General Overview of Nano Medicine-Efficacy in Therapeutic Science and Curre...ceijjournals
Nanotechnology’s introduction has dramatically improved a number of scientific fields, one of which is
medicinal research. Nanomedicine is aimed to offer healthcare medications and chemicals a new
dimension. The small size of nanoparticles, permits them to circulate in the body without interrupting
oxygenation and escape filtration by both the renal and gastrointestinal networks. These are the few
properties that distinguish them apart from traditional therapeutic procedures. The increased permeability
and durability effect result in successful penetration inside the tumor tissues, providing cancer treatment a
new lease on life. Efficient transportation pathways, on the other hand, produce genotoxicity and
mutagenicity by interacting with genes that are essential for smooth functioning. As the specific
interactions of nanomedicines with biological systems are still unknown, comprehending nanomedicines'
toxicological effects is tough. The lack of regulatory direction in this field remains a research gap that we
would want to examine in this study.
Coronavirus disease 2019 (COVID-19) pandemic has a catastrophic impact on human
health.1 They cause the severe acute respiratory syndrome, leading to a significant
increase in morbidity and mortality worldwide.2 In addition to ample vaccine
availability for mitigating COVID-19, there is an urgency for an effective, easily
compatible antiviral drug. Although antivirals like Ramdesivir and Favipiravir was
tried in the early pandemic, yet it failed to exhibit the expected potency.2,3
Basics of Molnupiravir:
It is an isopropyl ester prodrug initially developed by Emory inventory. Later the
same was acquired by Merck and Ridgeback partnership.4 So far, the antivirals
terminated the elongation of RNA-chain by targeting the viral polymerase, which was
not a promising treatment of SARS-CoV-2 infections. They also had a limitation in
their administration. Whereas molnupiravir, the so-called magic pill, is an exceptional
drug with a unique error catastrophic mechanism that advances in increasing the rate
of mutation in the viral genome, outweighing the
Francis Derk1, Troy Wilde2,
Tim Pham2, Mike Griffiths3
1South Texas VA Medical Center (San Antonio, United States)
2UTHSC (San Antonio, United States)
3AOTI (Oceanside, United States)
EWMA 2013 - Ep543 - Evidence Based Wound Conversion Algorithm for University ...EWMAConference
Francis Derk1, Troy Wilde2,
Tim Pham2, Mike Griffiths3
1South Texas VA Medical Center (San Antonio, United States)
2UTHSC (San Antonio, United States)
3AOTI (Oceanside, United States)
Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Pat...science journals
We carried out a controlled study on 240 patients diagnosed with Peyronie's Disease (PD). We have divided two treatment groups, which differ from each other only for the association with PTX-penile injection.
Physician-initiated daily verbal reminders to remove unnecessary urinary catheters decreased catheter duration more than nurse-initiated reminders. In a study comparing the two approaches, the mean catheter duration after physician reminders was 0.5 days compared to 1.7 days for nurse reminders. The physician reminders also significantly decreased catheter duration compared to a control group that received no reminders. Daily reminders from an infectious disease physician who was familiar with the hospital teams may have led to quicker catheter removal than from infection control nurses.
Evaluation of Oxidative status of gout patients in a Cameroonian urban hospit...J-réné Nkeck
This study evaluated the oxidative status of patients experiencing acute gout attacks compared to healthy controls in Cameroon. The study found higher levels of malondialdehyde, a marker of oxidative stress, in patients with gout attacks. However, levels of antioxidant enzymes like superoxide dismutase, glutathione peroxidase and catalase were similar between patients and controls. Thus, patients with gout attacks have evidence of elevated oxidative stress based on higher malondialdehyde levels, but their overall antioxidant defenses appear to be similar to healthy individuals.
The Emergence of Baricitinib: A Story of Tortoises Versus HaresJustin Stebbing
Baricitinib is a once-daily orally administered JAK1/2 inhibitor, which inhibits the signaling of many cytokines and has been approved for the treatment of moderate to severe rheumatoid arthritis (RA) based on long-term randomized dosing against both placebo and standard of care, notably tumor necrosis factor (TNF)- alpha blockade. Its use for the treatment of coronavirus disease 2019 (COVID-19) was originally suggested after a search of the extensive BenevolentAI knowledge graph for approved drugs that could be used in this pandemic An advantage of approved drugs is that they have a known safety profile and can therefore be rapidly approved in fast-moving pandemics.
This study evaluated the effectiveness of using ultraviolet-C (UV-C) radiation for environmental disinfection in reducing healthcare-associated infections (HAIs) at a hospital in California. The study found that implementing a dedicated service model for facility-wide UV-C treatment significantly reduced the incidence of HAIs by 34.2% compared to the period before UV-C intervention. Regular UV-C treatments of patient rooms and high-touch surfaces maintained lower HAI rates and reduced the total number and incidence of HAIs by 28.8% compared to traditional cleaning methods alone. The results suggest that continuous, monitored UV-C disinfection of the hospital environment can decrease disease transmission and improve patient outcomes.
A General Overview of Nano Medicine-Efficacy in Therapeutic Science and Curre...Berklin
Nanotechnology’s introduction has dramatically improved a number of scientific fields, one of which is medicinal research. Nanomedicine is aimed to offer healthcare medications and chemicals a new dimension. The small size of nanoparticles, permits them to circulate in the body without interrupting oxygenation and escape filtration by both the renal and gastrointestinal networks. These are the few properties that distinguish them apart from traditional therapeutic procedures. The increased permeability and durability effect result in successful penetration inside the tumor tissues, providing cancer treatment a new lease on life. Efficient transportation pathways, on the other hand, produce genotoxicity and mutagenicity by interacting with genes that are essential for smooth functioning. As the specific interactions of nanomedicines with biological systems are still unknown, comprehending nanomedicines' toxicological effects is tough. The lack of regulatory direction in this field remains a research gap that we would want to examine in this study.
Malignant Transformation in A Case of Multiple Osteochondromas: Role of FDG P...submissionclinmedima
We present a 19-year-old man affected by osteochondromatosis since he aged 9. Multiple enchondromas showed asymmetric distribution of osseous and cartilage lesions with major deformities of pelvis and long bones and minor lesions in left scapula and few ribs.
A 60 year old male was referred to a tertiary referral centre with a chronic dry cough. He was a lifelong non-smoker. Clinical examination was unremarkable. AssessmentIGE, RAST to common allergens, eosinophils and alpha one anti-trypsin were within normal limits. Barium swallow did not show any oesophageal dysmotility, gastric outlet obstruction or reflux
More Related Content
Similar to Nanomedicine Approach for the Rapid Healing of Diabetic Foot Ulcers with Silver Nanoparticles
Nanoparticles as a novel and promising antiviral platform in veterinary medicineAhmed Hasham
Traditional veterinary virus vaccines, such as inactivated and live-attenuated vaccines, have achieved tremendous success
in controlling many viral diseases of livestock and chickens worldwide. However, many recent viral outbreaks caused by
diferent emerging and re-emerging viruses continue to be reported annually worldwide. It is therefore necessary to develop
new control regimens. Nanoparticle research has received considerable attention in the last two decades as a promising
platform with signifcant success in veterinary medicine, replacing traditional viral vector vaccines. However, the feld of
nanoparticle applications is still in its initial phase of growth. Here, we discuss various preparation methods, characteristics,
physical properties, antiviral efects, and pharmacokinetics of well-developed nanoparticles and the potential of nanoparticles
or nano-vaccines as a promising antiviral platform for veterinary medicine.
A cohort study evaluated the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on older COVID-19 patients. 17 patients received DMB and 26 did not. Significantly fewer DMB patients required oxygen therapy (17.6% vs 61.5%). DMB exposure was associated with reduced odds of oxygen therapy need and intensive care support. The study supports larger trials to determine if DMB can ameliorate COVID-19 severity through immunomodulation.
This study evaluated the efficacy and safety of intravenous injection of Mycobacterium w (Mw) in treating gram-negative sepsis.
The study involved 30 patients over 18 years of age with gram-negative sepsis and single organ dysfunction. Patients received intravenous Mw injections in addition to standard care. Results showed significant improvements in vital signs, organ function markers, and sepsis severity scores from day 2 onward compared to baseline. No major adverse events occurred.
The study concluded that intravenous Mw appears to be a well-tolerated and effective adjuvant treatment for gram-negative sepsis when added to standard care, as demonstrated by improved clinical outcomes. However, larger randomized controlled trials are still needed to confirm these findings.
This document summarizes clinical data from 53 patients with severe Covid-19 who were treated with the investigational antiviral remdesivir through a compassionate use program. Key findings include:
- 68% (36 patients) showed improvement in oxygen support needs, including 57% of those on mechanical ventilation being extubated.
- 47% (25 patients) were discharged from the hospital, and 13% (7 patients) died, with a higher mortality among those receiving invasive ventilation.
- Remdesivir appeared to have a favorable safety profile based on previous experience in Ebola patients, though efficacy will need to be determined through ongoing randomized controlled trials.
This survey aimed to assess clinicians' use of stereotactic radiotherapy and targeted therapies for metastatic renal cell carcinoma and determine support for future clinical trials. The primary objective was to evaluate the proportion of clinicians using radiotherapy for metastatic renal cell carcinoma. Secondary objectives included evaluating the proportion using targeted therapies and radiotherapy simultaneously, stopping targeted therapies for radiotherapy, and supporting further research. The online survey was distributed to members of urology and oncology groups in Australia and New Zealand to collect data on current practices. Results and conclusions will be presented at an upcoming conference.
nanobiotechnology, achievements and development prospectsYULIU384426
Nanobiotechnology has significant applications in fields like medicine, imaging, and drug delivery. It has been used to develop tools for intelligent drug delivery, gene therapy, biosensors, diagnostics, and biomaterials. Some key achievements include using nanoparticles for more precise disease detection, developing techniques to detect genetic sequences, creating protein chips to study proteomics, and developing systems to sort rare cells. Nanobiotechnology also shows promise for targeted drug delivery, gene delivery without viruses, using liposomes to cross cell membranes, engineering surfaces at the nanoscale, and streamlining the drug development process. Its future applications could include more precise diagnosis and regenerative medicine through technologies like nanosensors and nanomedicine. Continued development may help improve
This document summarizes a study that developed a CT-based radiomics score to noninvasively evaluate the tumor immune microenvironment (TIME) in 2272 gastric cancer patients. The radiomics score achieved good performance in predicting the neutrophil-to-lymphocyte ratio (NLR) status in the TIME. Notably, the radiomics score was comparable to the immunohistochemistry-derived NLR status in predicting patient survival outcomes. Furthermore, the study found that objective response rates to anti-PD-1 immunotherapy were significantly higher in patients with a low radiomics score compared to those with a high radiomics score. The radiomics imaging biomarker provides a noninvasive method for evaluating the TIME and its correlation with prognosis and response to
Short-term improvement of clinical parameters and microbial diversity in peri...M ALTAMIMI
Indocyanine green-based antimicrobial photodynamic therapy as an adjunct to scaling and root planing resulted in significantly greater reductions in periodontal pocket depth and clinical attachment loss compared to scaling and root planing alone. Microbiome analysis showed a reduction in key periodontal pathogens like Porphyromonas gingivalis and favorable shifts in the subgingival microbiome with the addition of photodynamic therapy. The combination treatment led to significantly greater short-term clinical improvements and microbial changes associated with periodontal healing.
A General Overview of Nano Medicine-Efficacy in Therapeutic Science and Curre...ceijjournals
Nanotechnology’s introduction has dramatically improved a number of scientific fields, one of which is
medicinal research. Nanomedicine is aimed to offer healthcare medications and chemicals a new
dimension. The small size of nanoparticles, permits them to circulate in the body without interrupting
oxygenation and escape filtration by both the renal and gastrointestinal networks. These are the few
properties that distinguish them apart from traditional therapeutic procedures. The increased permeability
and durability effect result in successful penetration inside the tumor tissues, providing cancer treatment a
new lease on life. Efficient transportation pathways, on the other hand, produce genotoxicity and
mutagenicity by interacting with genes that are essential for smooth functioning. As the specific
interactions of nanomedicines with biological systems are still unknown, comprehending nanomedicines'
toxicological effects is tough. The lack of regulatory direction in this field remains a research gap that we
would want to examine in this study.
Coronavirus disease 2019 (COVID-19) pandemic has a catastrophic impact on human
health.1 They cause the severe acute respiratory syndrome, leading to a significant
increase in morbidity and mortality worldwide.2 In addition to ample vaccine
availability for mitigating COVID-19, there is an urgency for an effective, easily
compatible antiviral drug. Although antivirals like Ramdesivir and Favipiravir was
tried in the early pandemic, yet it failed to exhibit the expected potency.2,3
Basics of Molnupiravir:
It is an isopropyl ester prodrug initially developed by Emory inventory. Later the
same was acquired by Merck and Ridgeback partnership.4 So far, the antivirals
terminated the elongation of RNA-chain by targeting the viral polymerase, which was
not a promising treatment of SARS-CoV-2 infections. They also had a limitation in
their administration. Whereas molnupiravir, the so-called magic pill, is an exceptional
drug with a unique error catastrophic mechanism that advances in increasing the rate
of mutation in the viral genome, outweighing the
Francis Derk1, Troy Wilde2,
Tim Pham2, Mike Griffiths3
1South Texas VA Medical Center (San Antonio, United States)
2UTHSC (San Antonio, United States)
3AOTI (Oceanside, United States)
EWMA 2013 - Ep543 - Evidence Based Wound Conversion Algorithm for University ...EWMAConference
Francis Derk1, Troy Wilde2,
Tim Pham2, Mike Griffiths3
1South Texas VA Medical Center (San Antonio, United States)
2UTHSC (San Antonio, United States)
3AOTI (Oceanside, United States)
Pentoxifylline Associated with Other Antioxidants (Multimodal Therapy) on Pat...science journals
We carried out a controlled study on 240 patients diagnosed with Peyronie's Disease (PD). We have divided two treatment groups, which differ from each other only for the association with PTX-penile injection.
Physician-initiated daily verbal reminders to remove unnecessary urinary catheters decreased catheter duration more than nurse-initiated reminders. In a study comparing the two approaches, the mean catheter duration after physician reminders was 0.5 days compared to 1.7 days for nurse reminders. The physician reminders also significantly decreased catheter duration compared to a control group that received no reminders. Daily reminders from an infectious disease physician who was familiar with the hospital teams may have led to quicker catheter removal than from infection control nurses.
Evaluation of Oxidative status of gout patients in a Cameroonian urban hospit...J-réné Nkeck
This study evaluated the oxidative status of patients experiencing acute gout attacks compared to healthy controls in Cameroon. The study found higher levels of malondialdehyde, a marker of oxidative stress, in patients with gout attacks. However, levels of antioxidant enzymes like superoxide dismutase, glutathione peroxidase and catalase were similar between patients and controls. Thus, patients with gout attacks have evidence of elevated oxidative stress based on higher malondialdehyde levels, but their overall antioxidant defenses appear to be similar to healthy individuals.
The Emergence of Baricitinib: A Story of Tortoises Versus HaresJustin Stebbing
Baricitinib is a once-daily orally administered JAK1/2 inhibitor, which inhibits the signaling of many cytokines and has been approved for the treatment of moderate to severe rheumatoid arthritis (RA) based on long-term randomized dosing against both placebo and standard of care, notably tumor necrosis factor (TNF)- alpha blockade. Its use for the treatment of coronavirus disease 2019 (COVID-19) was originally suggested after a search of the extensive BenevolentAI knowledge graph for approved drugs that could be used in this pandemic An advantage of approved drugs is that they have a known safety profile and can therefore be rapidly approved in fast-moving pandemics.
This study evaluated the effectiveness of using ultraviolet-C (UV-C) radiation for environmental disinfection in reducing healthcare-associated infections (HAIs) at a hospital in California. The study found that implementing a dedicated service model for facility-wide UV-C treatment significantly reduced the incidence of HAIs by 34.2% compared to the period before UV-C intervention. Regular UV-C treatments of patient rooms and high-touch surfaces maintained lower HAI rates and reduced the total number and incidence of HAIs by 28.8% compared to traditional cleaning methods alone. The results suggest that continuous, monitored UV-C disinfection of the hospital environment can decrease disease transmission and improve patient outcomes.
A General Overview of Nano Medicine-Efficacy in Therapeutic Science and Curre...Berklin
Nanotechnology’s introduction has dramatically improved a number of scientific fields, one of which is medicinal research. Nanomedicine is aimed to offer healthcare medications and chemicals a new dimension. The small size of nanoparticles, permits them to circulate in the body without interrupting oxygenation and escape filtration by both the renal and gastrointestinal networks. These are the few properties that distinguish them apart from traditional therapeutic procedures. The increased permeability and durability effect result in successful penetration inside the tumor tissues, providing cancer treatment a new lease on life. Efficient transportation pathways, on the other hand, produce genotoxicity and mutagenicity by interacting with genes that are essential for smooth functioning. As the specific interactions of nanomedicines with biological systems are still unknown, comprehending nanomedicines' toxicological effects is tough. The lack of regulatory direction in this field remains a research gap that we would want to examine in this study.
Similar to Nanomedicine Approach for the Rapid Healing of Diabetic Foot Ulcers with Silver Nanoparticles (20)
Malignant Transformation in A Case of Multiple Osteochondromas: Role of FDG P...submissionclinmedima
We present a 19-year-old man affected by osteochondromatosis since he aged 9. Multiple enchondromas showed asymmetric distribution of osseous and cartilage lesions with major deformities of pelvis and long bones and minor lesions in left scapula and few ribs.
A 60 year old male was referred to a tertiary referral centre with a chronic dry cough. He was a lifelong non-smoker. Clinical examination was unremarkable. AssessmentIGE, RAST to common allergens, eosinophils and alpha one anti-trypsin were within normal limits. Barium swallow did not show any oesophageal dysmotility, gastric outlet obstruction or reflux
Food Allergy in School-Going Adolescents and Its Association with Depression ...submissionclinmedima
The aim of thisstudy wasto document food allergy in school going adolescents and its association with depression. 1.2.Methods: An observational cross-sectionalstudy was conducted from 2016 to 2018 in middle income schools of Karachi after receiving institutional review board approval of Karachi Medical and Dental College (ref:020/16). Students, male and female, with age range of 11 to 17 years, were included. Students who refused to fill questionnaire were excluded
Symbrachydactyly is a unilateral hand anomaly with failure of formation of fingers and presence of rudimentary digits that include elements of nail plate, bone, and cartilage. Vascular dysgenesis and disruption of apical ectodermal ridge of developing limb bud are possible aetiologies
Physiologic Papillomatosis of the Penis Mimicking Genital War- ts: Role of De...submissionclinmedima
Physiologic papillomatosis of the penis is a benign, non-infectious affection that may be confused to genital warts and it is assimilated to the vestibular papillomatosis in the woman. A young man of 21 years old, came to our department with a history of non protected sexual activity.
Effect of Time of Echo on 1H-magnetic Resonance Spectroscopy Imaging of Metab...submissionclinmedima
The aim of this study is to evaluate the effect of time of echo (TE) on magnetic resonance spectroscopy imaging (MRSI) of metabolites in maxillofacial carcinoma. 1.2. Methods: Twenty maxillofacial carcinoma patients and 10 healthy volunteers were recruited to undergo 1.5-Tesla high-resolution routine MRI and multi-voxel MRSI with a TE of 35 ms and 144 ms.
Fragmented QRS Complex is associated with the Left Ventricular Remodeling in ...submissionclinmedima
A total of 140 patients with AMI were enrolled. Accoridng to the presence of fQRS in presenting electrocardiogram. The patients were divided into fQRS group and NonfQRS group. Real-time three-dimensional echocardiograph parameters measured in-hospital and 6-month follow-up period were collected.
We report a case of a 23 year old female with history of fever and malaise since 3 days. We received her blood sample for complete blood count along with peripheral blood smear examination. The blood test showed leukocytosis 23,500 cells/uL, Hemoglobin- 12.2 gm/dl and Platelet count 1, 58,000/Ul. The peripheral blood examination showed marked lymphocytosis with presence of 24% atypical lymphocytes along with 46% lymphocytes and 30% Neutrophils. Based on the peripheral blood examination..
A 39 year old right handed lady presented with a 3 month history of worsening chin and bilateral leg tremors. Secondary to this she had multiple falls.
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Nanomedicine Approach for the Rapid Healing of Diabetic Foot Ulcers with Silver Nanoparticles
1. Journal of Clinical and
Medical Images
ISSN: 2640-9615
Research Article
Nanomedicine Approach for the Rapid Healing of Diabetic Foot
Ulcers with Silver Nanoparticles
Almonaci-Hernández CA1&
, Luna-Vazquez-Gomez R2&
, Luna-Vazquez-Gomez RA3
, Valenciano-Vega JI4
, Carriquiry-Chequer NI2
,
Rembao-Hernández A2
, Gomez-Zendejas ML5
, Almanza-Reyes H6
, Garibo-Ruiz D7
, Pestryakov A8
and Bogdanchikova N9*
1
Integral and Advance Clinic, Ensenada, Baja California, Mexico
2
School of Medicine, Campus Ensenada, Autonomous University of Baja California, Mexico
3
Faculty of Medicine, Campus Mexicali. Autonomous University of Baja California, Mexico
4
Hospital El Mirador of ISSSTECALI Tijuana, Baja California, Mexico
5
Faculty of Science, Campus Ensenada. Autonomous University of Baja California, Mexico
6
Faculty of Medicine and Psychology, Campus Tijuana. Autonomous University of Baja California, Mexico
7
CONACYT - Center of Nanoscience and Nanotechnology, National Autonomous University of Mexico, Mexico
8
Research School of Chemistry & Applied Biomedical Science, Tomsk Polytechnic University, Russia
9
Department of Nanomaterial Physicochemistry Center of Nanoscience and Nanotechnology, National Autonomous
Volume 3 Issue 2- 2020
Received Date: 07 Jan 2020
Accepted Date: 22 Jan 2020
Published Date: 28 Jan 2020
2. Keywords
Diabetic foot ulcers; Diabetes
mellitus; Silver nanoparticles;
Nanomedicine; Chronic ul-
cers; Wound healing
1. Abstract
1.1. Objectives: We present the use of silver nanoparticles (AgNPs) for 3 the treatment of Diabetic Foot
Ulcers (DFU) of grade 2 and 3 of Wagner classification.
1.2. Methods: Ulcers were daily treated by topical administration of AgNPs (at 1.8mg/mL of metallic
silver) in addition to conventional antibiotics.
1.3. Results: In all three cases presented here, a significant improvement in the healing evolution of
ulcers was observed. The edges of the lesion reached the point of closure in 2 of the 3 clinical cases.
1.4. Conclusions: This work reports a nanomedicine approach for the successfully treatment of DFU
of Wagner classification degrees 2 and 3. Daily topical administration of AgNPs solution with metal-
lic silver concentration of 1.8mg/mL causes a healing improvement of DFU in less than 60 days in
average. The results constituted the basis for further studies on the use of AgNPs for the treatment of
diabetic and other ulcers from different origins.
*Corresponding Author (s): Nina Bogdanchikova, Almonaci-Hernández CA, Lu-
na-Vazquez-Gomez R, Department of Centro of Nano Science and Nanotechnology National
Autonomous University of Mexico, UNAM, Km. 107 Carretera Tijuana-Ensenada, Ensenada,
Baja California, 22860 Mexico, E-mail: nina@cnyn.unam.mx
clinandmedimages.com
Citation: Bogdanchikova N, Department of Center of Nanoscience and Nanotechnology, National Autono-
mous University of Mexico. Journal of Clinical and Medical Images. 2020; V3(2): 1-7.
3. Introduction
Diabetes Mellitus (DM) is one of the most common chronic and
metabolic diseases. According with the World Health Organiza-
tion, in 2014 there were 422 million of diabetic people and 1.5 mil-
lion of people have died due to this illness in 2012 [1,2]. In Mex-
ico DM is the second major cause of death [3]. Impaired wound
healing is a common complication and the main cause of hospi-
talization and lower limbs amputation in patients with DM. This
causes what is known as Diabetic Foot Ulcers (DFU). The lifetime
risk of patients with DM to develop DFU is 25%. As a consequence
of DM, it is estimated that a lower limb is lost some where in the
world every 30 seconds [4,5].
Conventional treatments for DFU include debridement, adminis-
tration of antimicrobial agents, use of devices for off-loading, ap-
plication of silver impregnated dressings, topical administration
of cell growth factors, surgical techniques and amputation [6,8].
However, all of them have shown limited clinical success. Due to
polymicrobial infections, DFU are known to heal slowly [9,10].
Microbial infections found in DFU consist of 73% aerobic and 27%
anaerobic bacteria and also microorganisms with MultiDrug Re-
sistance (MDR) [11,12]. To overcome those infections, silver-im-
pregnated dressings have been used, but the need for constant
Author Contributions: Almonaci-Hernandez CA, Luna-Vazquez-Gomez R, These authors have contrib-
uted equally to this article.
3. (with a metallic silver concentration of 1.8 mg/mL) was performed
daily. To record the evolution of the wound healing process, photo-
graphs were taken before and after the treatment with AgNPs. Here
it is presented three clinical cases of diabetic patients with different
grades of DFU according with Wagner classification (Figure 2).
First patient (P1, Figure 2a) is a 77 years old female with controlled
type 2 diabetes, with a plantar Wagner-2 ulcer. The wound is lo-
cated at the metatarsal region of the first toe of the left foot. As
observed in Figure 2a the ulcer was restricted to an area of 4 cm
x 4 cm and exhibits hyperkeratosis in the affected and surround-
ing tissue, associated with desquamation at the metatarsal region
and fetid odor perception. Some grade of inflammation in forefoot
Figure 1: TEM image of AgNPs showing their spheroidal morphology and size.
Volume 3 Issue 2 -2020 Research Article
Clinandmedimages.com 3
Figure 2: Chronological evolution of different diabetic foot ulcers treated with topical administration
of AgNPs.
4. and toe was observed. Daily treatment of topical administration of
AgNPs solution started after the debridement of the lesion. After
20 days of AgNPs administration, the ulcer showed a decrease in
hyperkeratosis, noticeable on the lateral side of the first toe, while
the metatarsal region surrounding the injury regained its normal
appearance. It is shown a decrease of edema of the forefoot and
toes and a peripheral improved of the pigmentation indicating an
active edge of healing. No fetid odor was perceived. Forty days
after the beginning of treatment the hyperkeratosis was minimal,
the surrounding skin has regained its normal characteristics and
desquamation was only noticeable at the fold of the first toe. The
necrotic tissue disappeared and normal re-epithelialization process
and a normalization of the pigmentation were evident.
The second patient (P2, Figure 2b) is a 63 years old male with con-
trolled type 2-diabetes, who exhibited an ulcer grade 3 according
to Wagner classification. Ulcer exhibits a pitting morphology with
raised edges located on the lateral side of the third toe of the right
foot. As observed in Figure 2b changes in pigmentation are evident.
After 18 days of a daily topical administration of AgNPs, the DFU
showed reduction of the wound area in more than 50%, with evi-
dent re-epithelialization, active edges and presence of granulation
tissue in the center of the ulcer. At the 25th day of treatment, an
imminent closure of the ulcer is shown by secondary intention.
Finally, after 37 days post-AgNPs treatment, the ulcer edges have
been addressed, culminating in the closure of the injury where no
necrosis or inflammation was observed.
The third patient (P3, Figure 2c) is a 59 years old female patient
with controlled type 2 diabetes, exhibited a plantar ulcer in the
left hindfoot without vascular involvement. After 4 weeks under a
conventional antibiotics schedule no improvement in the evolution
of the ulcer was observed. Chronological evolution of DFU from
Features Heberprot-P (Cuba) Nagsil Dermo (Mexico-Russia)
On the market since 2007 2015
International distribution 15 countries 10 countries
Registration as Medicine Cosmetic
Origin Recombinant protein Silver nanoparticles
Number of treated patients More than 100,000 More than 420
Treatment duration 8 - 11 weeks 3 - 6 weeks (in average)
Treatment cost in Mexico
136,000 - 187,000 MEX pesos (7,555 – 10,390
USD)
1,000 MEX pesos (56 USD)
Necessary to administer along with
antibiotics
Yes No
Hospitalization for treatment and
product administration
Required No Only for initial debridement
Exclussion criteria of patients
This product is not recommended for patients
with: High blood pressure or hypertenssion
Risk of brain hemorrages
Risk of thrombosis
Blood glucose levels ≥ 160 Ulcers with necrotic
tissue
None
Stages of Wagner ulcer classification
for an effective treatment
1 and 2 1, 2 and 3
Route of administration Intra and perilesional zones Topically with spray
Shelf-life of the product 1 year 2-4 years
Experitation days beyond first use 3 days 1 year
Table 1. Comparison of Herberprot-P (Cuba) and Nagsil Dermo (Mexico-Russia) products available on the market for
the effective treatment of diabetic foot ulcers.
Volume 3 Issue 2 -2020 Research Article
Clinandmedimages.com 4
5. P3 before and after treatment with AgNPs was observed in Figure
2c. It is shown the initial appearance of a Wagner 2 ulcer after the
debridement process. The DFU was located at the hindfoot and
superimposed on the tarsal region of the left foot, with irregular
contours and edges with hyperkeratosis. After 30 days of treatment
with AgNPs solution, there was an improvement of the ulcer, clear-
ly observed as approximately 20% reduction of the wound surface
area. The evolution of the healing process after 42 and 45 days of
AgNPs administration showed a progressive diminishment of the
lesion extent. The outer contour of the ulcer showed a progressive
decrease of hyperkeratosis. An evident improvement of the coping
was observed along the edges of the DFU, while granulation tissue
is depicted at the center of the ulcer. The central zone of the ulcer
showed a diminishment of its diameter with an evident improve-
ment in pigmentation, re-epithelialization process and the pres-
ence of active edges that favoring closure of the injury.
6. Discussion
DFU has been recognized as a worldwide health problem, espe-
cially in developing countries and as the number of diabetic pa-
tients continues to rise, so will be the number of DFU [25]. These
types of ulcers are multifactorial, besides the presence of MDR mi-
croorganisms on it increases the risk for a chronic infection, limb
amputation and morbidity [26,27]. The microbicidal properties
of AgNPs are broader than ones of common antibiotics, which is
suitable to 1 treat wounds with polymicrobial infections includ-
ing MDR microorganisms also found in DFU [12]. The capability
of AgNPs to accomplish successful DFU healing, could be exerted
by several processes, indeed, the most important is their efficient
wide-spectra antimicrobial properties [15,27]. Because the precise
microbicidal mechanism of AgNPs has not been well established,
it is considered to be multifactorial [28,29]. For example, AgNPs
can interact with peptidoglycans present in both bacterial cell wall
and membrane, damaging their integrity and causing a leakage of
intracellular contents [16,30]. AgNPs also interact with intracellu-
lar proteins, interfering with microbial DNA duplication and in-
ducing the generation of reactive oxygen species that finally leads
to bacterial cell death by oxidative stress [27]. Once the infection
is eradicated, the anti-inflammatory properties of AgNPs promote
wound healing by decreasing the expression of pro-inflammato-
ry cytokines and by reducing the infiltration of lymphocytes and
mast cells. Causing with this a diminishment of local and systemic
inflammatory response [16,22]. Although AgNPs in wound heal-
ing has been studied, their role in curing diabetic foot ulcers has
been never addressed, thus limited information concerning this is
available. Moreover, AgNPs used in other studies have produced
genotoxic effects. Therefore, in attempts to compare the efficacy of
AgNPs treatment for DFU, we searched products on the market ca-
pable to cure DFU. In this sense, we found a Cuban product named
Heberprot-P [6]. To address the efficacy of both products to heal
DFU we present the following comparison (Table 1).
Heberprot-P is based on the recombinant human Epidermal
Growth Factor (rhEGF), a cytokine that stimulates cell growth and
differentiation. It has been associated the poor ability of DFU to
heal with the low levels of growth factors in the wound site [31].
Thus, the injection of Heberprot-P in the intra and perilesional
zones of DFU facilitates the healing process in the wound. It has
been reported that AgNPs promote wound healing due to several
processes, such as the expression of fibrogenic cytokines, migra-
tion of keratinocytes and induction of fibroblast differentiation to
myofibroblasts. These allowed to promote wound contraction and
epidermal re-epithelialization [19, 22, 32].
It is worth mention that we recently reported that Argovit AgNPs
have non genotoxic effects on cell lines at concentrations closer
to the IC50 (3.5μg/mL of metallic silver) [24]. Moreover, Argovit
AgNPs harbors many advantages over other silver formulations
available on the market, because it has been approved by interna-
tional instances as cosmetic and has been applied in medical devic-
es for human use [23]. Argovit AgNPs is available on the market
and distributed as cosmetic by the company Bionag S.A.P.I. de C.V.
According with the supplier, this product cures more than 90% of
patients with DFU with Wagner ulceration of stages 1 to 3 in ap-
proximately 2 months. The remaining patients are cured slower be-
cause they do not follow the directions given by the supplier.
Thus, to the best of our knowledge, this work represents the first
nanomedicine approach study performed for the successfully
treatment of DFU of Wagner classification degrees 2 and 3 by a
daily topical administration of AgNPs solution with metallic sil-
ver concentration of 1.8 mg/mL. AgNPs administered caused an
improvement of the wound healing in average in less than 60 days
of treatment.
The implementation of this nanotechnology for the rapid healing
of diabetic foot ulcers could help to drastically reduce the cost re-
lated to the care and treatment of DFU in the public health system.
Therefore, this study lays the 1st bases for further systematic clin-
ical and basic research on the usage of AgNPs for the treatment of
chronic ulcers such as DFU.
Volume 3 Issue 2 -2020 Research Article
Clinandmedimages.com 5
6. 7. Conclusions
To the best of our knowledge, this work reports the first nanomed-
icine approach study performed for the successfully treatment of
DFU of Wagner classification degrees 2 and 3, where daily topical
administration of AgNPs solution with metallic silver concentra-
tion of 1.8 mg/mL causes an improvement of the wound healing in
average in less than 60 days of treatment. Therefore, this study lays
the bases for further systematic clinical and basic research on the
usage of AgNPs for the treatment of chronic ulcers such as DFU.
8. Acknowledgements
The authors thank the funding through CONACYT projects No.
279889, 269071, 1073, DGAPA PAPIIT-UNAM IT200114 and
RFBR project No 18-29-24037. Medical support was given by
Dr. Isis Cabrera, Carmen Enriques, Willfred Cardenas Acosta,
Michel Natay Peraza Perales, Alejandra Rembao Hernandez and
Nora Ines Carriquiry Chequer. We are grateful to Dr. Leonel Cota
(CNyN-UNAM) for the studentships given through the CONA-
CYT-SNI 3 researcher fund and to Dr. V. Burmistrov for the kindly
donation of Argovit AgNPs.
9. Declaration of Conflicting Interests
The authors declared no potential conflict of interest with respect
to the research, authorship, and/or publication of this article.
10. Author Contributions: Almonaci-Hernandez CA, Lu-
na-Vazquez-Gomez R
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