Here was a presentation I gave on toenail trauma with the slides involved. It was requested by a Worcester Emergency Resident. I hope you find it helpful. To watch video it is below the pictures.
Understand the relationship between anatomy , functions and injuries of the nail bed
Develop repair and reconstruction techniques for the injuries and their complications
1. The document provides an algorithmic approach for evaluating and treating soft-tissue injuries of the fingertip, outlining methods based on the type and extent of injury.
2. A variety of reconstruction techniques are described, including V-Y flaps, triangular flaps, and cross-finger flaps from neighboring digits depending on the location and size of the defect.
3. The goal of treatment is to provide durable coverage while preserving length, sensation and function of the injured digit.
The document discusses various reconstructive options for fingertip injuries, including healing by secondary intention, skin grafting, and local flap reconstruction techniques such as volar V-Y flaps, bilateral V-Y flaps, and cross-finger flaps. The goals of fingertip reconstruction are to close the wound, maximize sensory return, preserve length and joint function, and obtain a satisfactory cosmetic appearance. Selection of the reconstructive method depends on factors like the level and depth of the injury, amount of exposed tissue, and characteristics of the individual patient.
This document discusses different types of nail shapes, parts, diseases, and arts including pre-school nail shapes, nail anatomy, nail diseases, finger nails, hands shapes, manicures, lotus nails, easy nail arts, airbrushing nail arts, nail shapes, nail materials, nail polish, polish pens, simple designs, types of decorative artificial nails, wrap string, nail stickers, nail accessories, cuticles, and damaged nails.
The diagram outlines the key structures of the human nail including the matrix, nail bed, nail grooves, hyponychium, free edge, nail plate, nail fold, lunula, perionychium, eponychium, and cuticle. The structures form layers from the base of the nail to the visible nail plate.
The document discusses the anatomy and applied aspects of nails. It describes the components of nails including the nail matrix, nail bed, cuticle, nail plate, and nail folds. It covers the development, structure, composition, blood supply, nerve supply, growth and functions of nails. The document also discusses various nail disorders and conditions, nail signs in systemic diseases, and the importance of nail analysis in forensic medicine and general medicine.
The document describes the different parts of the nail structure. It lists 7 parts: 1) the nail root or matrix which produces new nail cells, 2) the nail plate, the visible and dead outer layer of the nail, 3) the free edge which extends past the fingertip, 4) the hyponychium beneath the free edge which protects against infection, 5) the nail bed under the nail plate with ridges and grooves, 6) the visible part of the matrix at the base of the nail, and 7) the nail fold formed from thickened skin with two parts around the nail.
A subungual hematoma is a collection of blood under the fingernail caused by a direct injury to the nail. This blood collection puts pressure on the nailbed, causing intense pain. It is usually treated by draining the blood out through a hole made in the nail. Medical attention is needed if the hematoma involves over 25% of the nail area or the injury is severe. After draining the blood, the nail hole will grow out over time but there is a risk of permanent nail deformity from damage to the nailbed.
Understand the relationship between anatomy , functions and injuries of the nail bed
Develop repair and reconstruction techniques for the injuries and their complications
1. The document provides an algorithmic approach for evaluating and treating soft-tissue injuries of the fingertip, outlining methods based on the type and extent of injury.
2. A variety of reconstruction techniques are described, including V-Y flaps, triangular flaps, and cross-finger flaps from neighboring digits depending on the location and size of the defect.
3. The goal of treatment is to provide durable coverage while preserving length, sensation and function of the injured digit.
The document discusses various reconstructive options for fingertip injuries, including healing by secondary intention, skin grafting, and local flap reconstruction techniques such as volar V-Y flaps, bilateral V-Y flaps, and cross-finger flaps. The goals of fingertip reconstruction are to close the wound, maximize sensory return, preserve length and joint function, and obtain a satisfactory cosmetic appearance. Selection of the reconstructive method depends on factors like the level and depth of the injury, amount of exposed tissue, and characteristics of the individual patient.
This document discusses different types of nail shapes, parts, diseases, and arts including pre-school nail shapes, nail anatomy, nail diseases, finger nails, hands shapes, manicures, lotus nails, easy nail arts, airbrushing nail arts, nail shapes, nail materials, nail polish, polish pens, simple designs, types of decorative artificial nails, wrap string, nail stickers, nail accessories, cuticles, and damaged nails.
The diagram outlines the key structures of the human nail including the matrix, nail bed, nail grooves, hyponychium, free edge, nail plate, nail fold, lunula, perionychium, eponychium, and cuticle. The structures form layers from the base of the nail to the visible nail plate.
The document discusses the anatomy and applied aspects of nails. It describes the components of nails including the nail matrix, nail bed, cuticle, nail plate, and nail folds. It covers the development, structure, composition, blood supply, nerve supply, growth and functions of nails. The document also discusses various nail disorders and conditions, nail signs in systemic diseases, and the importance of nail analysis in forensic medicine and general medicine.
The document describes the different parts of the nail structure. It lists 7 parts: 1) the nail root or matrix which produces new nail cells, 2) the nail plate, the visible and dead outer layer of the nail, 3) the free edge which extends past the fingertip, 4) the hyponychium beneath the free edge which protects against infection, 5) the nail bed under the nail plate with ridges and grooves, 6) the visible part of the matrix at the base of the nail, and 7) the nail fold formed from thickened skin with two parts around the nail.
A subungual hematoma is a collection of blood under the fingernail caused by a direct injury to the nail. This blood collection puts pressure on the nailbed, causing intense pain. It is usually treated by draining the blood out through a hole made in the nail. Medical attention is needed if the hematoma involves over 25% of the nail area or the injury is severe. After draining the blood, the nail hole will grow out over time but there is a risk of permanent nail deformity from damage to the nailbed.
The document discusses various local flap options for reconstructing fingertip injuries. It describes the anatomy of the fingertip and goals of reconstruction which are to close wounds, maximize sensation, preserve length and function. Common local flaps include the volar V-Y flap, bilateral V-Y flaps, cross-finger flap, thenar flap and lateral island flaps. Choice depends on wound orientation and configuration.
The document contains information about muscles and vessels of the anterior leg compartment. It provides details about the tibialis anterior muscle, extensor digitorum longus muscle, and anterior tibial artery. However, some of the initial information provided about compartment contents and arterial branches is incorrect. The document seeks to clarify these inaccuracies.
This document discusses various techniques for reconstructing thumb deficiencies caused by trauma or congenital conditions. It describes options for different types and levels of thumb amputation or component loss, including replantation, osteoplastic reconstruction, phalangization, pollicization, toe transfers, and others. Key points covered include indications and disadvantages of each technique, as well as surgical details. Replantation is generally preferred if possible. Other options aim to restore length, stability, and function of the thumb through bone grafting, tendon transfers, and neurovascular repairs or transfers.
The document discusses the bones of the human foot. There are 27 bones in the foot classified into tarsal bones (7 bones including the talus, calcaneus, navicular, cuneiforms and cuboid), metatarsal bones (5 long bones) and phalanges (14 toe bones including proximal, middle and distal phalanges). The talus bone connects the foot to the lower leg and forms the ankle joint with the tibia and fibula. The subtalar joint is formed between the talus and calcaneus bones and allows for foot inversion and eversion.
The document discusses properties of the fibula bone:
1) The superior tibiofibular joint is a synovial joint that rarely communicates with the knee joint, and its joint line is below the tibial plateau.
2) Complete transection of the common peroneal nerve at the fibular neck causes foot drop, loss of eversion, and loss of sensation on the anterolateral leg.
3) Muscles attaching to the fibula include the extensors of the toes and big toe, flexor hallucis longus, and peroneus longus.
This document discusses different types of flaps that can be used in reconstructive surgery. It mentions perforator flaps, radial forearm flaps, posterior interosseous flap, and ulnar forearm flap as options to reconstruct areas of the body. The document is authored by Dr. Subrat K Jena and is focused on surgical techniques for reconstruction.
This document discusses hand reconstruction techniques following injuries. It introduces relevant hand anatomy and the goals of reconstruction, which are to restore functional, sensate hands that are aesthetically acceptable. Various local and regional flap options for covering dorsal and palmar hand defects ranging from fingertips to multiple fingers are described, including considerations for selecting the appropriate flap based on defect size and location. Post-operative care and potential complications are also mentioned.
The lateral compartment of the leg, also known as the fibular or peroneal compartment, contains two muscles - the peroneus longus and brevis. These muscles evert the foot and plantarflex the ankle joint. The peroneus longus originates on the head of the fibula and upper lateral fibular shaft and inserts on the medial cuneiform and base of the first metatarsal. The peroneus brevis originates on the lower lateral fibular shaft and inserts on the base of the fifth metatarsal. Both muscles are supplied by the superficial peroneal nerve.
The anterior leg compartment contains four muscles - Tibialis Anterior, Extensor Digitorum Longus, Extensor Hallucis Longus, and Peroneus Tertius. These muscles dorsiflex the ankle and extend the toes, arising from the tibia and fibula and inserting at various points on the foot. They are all supplied by the deep peroneal nerve. Injury to this nerve causes foot drop.
This document provides an overview of skin grafts. It defines grafts and flaps, and classifies grafts as autografts, allografts, or xenografts according to their donor site. Grafts are further classified by thickness as thin split-thickness, thick split-thickness, or full-thickness grafts. Success of grafts depends on factors like adequate blood supply, infection prevention, and wound care following transplantation. Common indications for skin grafts include treating skin loss from trauma, surgery, or wounds, while contraindications include unvascularized wound beds or active infection.
This document outlines principles for hand trauma management. It discusses initial survey and resuscitation, washing and dressing wounds, and splinting the hand. A secondary survey involves assessing history, vascularity, muscles/tendons, soft tissue defects, fractures, and imaging. Informed consent is required. Reconstruction may use early or delayed approaches. Early approaches reconstruct skeletal stabilization, vascularity, nerves, tendons, and soft tissue within 72 hours. Wound excision is classified as tidy or untidy wounds. Skeletal stabilization uses plates or external fixation. Revascularization uses end-to-end anastomoses or grafts. Nerves are repaired or transferred. Tendon reconstruction is early for simple fractures but staged for
A skin graft involves surgically removing a patch of skin from one area of the body and transplanting it to another area. There are two main types of skin grafts: partial-thickness grafts which contain the epidermis and part of the dermis, and full-thickness grafts which contain the entire dermis. Skin grafts are used to treat large wounds, burns, ulcers, and other conditions where there has been significant skin loss or damage. Recovery from a skin graft procedure may take several weeks and involve dressing changes and restricted activity. While skin grafts are usually successful, complications can include infection, scarring, or only partial healing of the grafted area.
This document provides an overview of hand surgery basics including physical exam and anatomy, common injuries and conditions such as lacerations, fractures, arthritis, and carpal tunnel syndrome. Treatment approaches are discussed for various conditions including suturing of lacerations, splinting of fractures, surgical excision of ganglions, and carpal tunnel release surgery. Emerging treatments like platelet-rich plasma injections are also mentioned.
Here is a presentation I use for patients with heel conditions. It covers plantar fasciitis, plantar fibroma, Achilles tendonitis, Haglund's deformity, posterior tibial tendonitis, Severe's Disease. To learn more about heel pain go to www.worcesterfootcare.com/heel
Preventing falls and amputation prevention april 2013Donald Pelto
This document discusses ways to prevent falls and foot wounds for those with diabetes. It notes that falls are the leading cause of injury deaths among older adults, with hip fractures being most common. Risk factors for falls include neuropathy, ankle instability, weakness, vision problems, foot deformities, environmental hazards, and certain medications. It recommends developing a fall risk plan that includes assistive devices, therapy, medical care, and podiatric evaluation. The document also outlines 3.5 ways to prevent foot wounds: examining feet daily, wearing proper shoes, trimming calluses professionally, and taking responsibility through self-education and regular medical checks. Four major reasons wounds don't heal fast are listed as high blood sugar, poor circulation, neuropathy, and
This document contains a summary of a lecture on emergency medicine topics related to the foot and ankle. It discusses ingrown toenails, including when antibiotics are needed and when part or all of the nail should be removed. It also covers topics like heel pain, stress fractures, warts, ulcers versus calluses, Charcot, and provides contact information for the lecturer to learn more.
The document discusses various local flap options for reconstructing fingertip injuries. It describes the anatomy of the fingertip and goals of reconstruction which are to close wounds, maximize sensation, preserve length and function. Common local flaps include the volar V-Y flap, bilateral V-Y flaps, cross-finger flap, thenar flap and lateral island flaps. Choice depends on wound orientation and configuration.
The document contains information about muscles and vessels of the anterior leg compartment. It provides details about the tibialis anterior muscle, extensor digitorum longus muscle, and anterior tibial artery. However, some of the initial information provided about compartment contents and arterial branches is incorrect. The document seeks to clarify these inaccuracies.
This document discusses various techniques for reconstructing thumb deficiencies caused by trauma or congenital conditions. It describes options for different types and levels of thumb amputation or component loss, including replantation, osteoplastic reconstruction, phalangization, pollicization, toe transfers, and others. Key points covered include indications and disadvantages of each technique, as well as surgical details. Replantation is generally preferred if possible. Other options aim to restore length, stability, and function of the thumb through bone grafting, tendon transfers, and neurovascular repairs or transfers.
The document discusses the bones of the human foot. There are 27 bones in the foot classified into tarsal bones (7 bones including the talus, calcaneus, navicular, cuneiforms and cuboid), metatarsal bones (5 long bones) and phalanges (14 toe bones including proximal, middle and distal phalanges). The talus bone connects the foot to the lower leg and forms the ankle joint with the tibia and fibula. The subtalar joint is formed between the talus and calcaneus bones and allows for foot inversion and eversion.
The document discusses properties of the fibula bone:
1) The superior tibiofibular joint is a synovial joint that rarely communicates with the knee joint, and its joint line is below the tibial plateau.
2) Complete transection of the common peroneal nerve at the fibular neck causes foot drop, loss of eversion, and loss of sensation on the anterolateral leg.
3) Muscles attaching to the fibula include the extensors of the toes and big toe, flexor hallucis longus, and peroneus longus.
This document discusses different types of flaps that can be used in reconstructive surgery. It mentions perforator flaps, radial forearm flaps, posterior interosseous flap, and ulnar forearm flap as options to reconstruct areas of the body. The document is authored by Dr. Subrat K Jena and is focused on surgical techniques for reconstruction.
This document discusses hand reconstruction techniques following injuries. It introduces relevant hand anatomy and the goals of reconstruction, which are to restore functional, sensate hands that are aesthetically acceptable. Various local and regional flap options for covering dorsal and palmar hand defects ranging from fingertips to multiple fingers are described, including considerations for selecting the appropriate flap based on defect size and location. Post-operative care and potential complications are also mentioned.
The lateral compartment of the leg, also known as the fibular or peroneal compartment, contains two muscles - the peroneus longus and brevis. These muscles evert the foot and plantarflex the ankle joint. The peroneus longus originates on the head of the fibula and upper lateral fibular shaft and inserts on the medial cuneiform and base of the first metatarsal. The peroneus brevis originates on the lower lateral fibular shaft and inserts on the base of the fifth metatarsal. Both muscles are supplied by the superficial peroneal nerve.
The anterior leg compartment contains four muscles - Tibialis Anterior, Extensor Digitorum Longus, Extensor Hallucis Longus, and Peroneus Tertius. These muscles dorsiflex the ankle and extend the toes, arising from the tibia and fibula and inserting at various points on the foot. They are all supplied by the deep peroneal nerve. Injury to this nerve causes foot drop.
This document provides an overview of skin grafts. It defines grafts and flaps, and classifies grafts as autografts, allografts, or xenografts according to their donor site. Grafts are further classified by thickness as thin split-thickness, thick split-thickness, or full-thickness grafts. Success of grafts depends on factors like adequate blood supply, infection prevention, and wound care following transplantation. Common indications for skin grafts include treating skin loss from trauma, surgery, or wounds, while contraindications include unvascularized wound beds or active infection.
This document outlines principles for hand trauma management. It discusses initial survey and resuscitation, washing and dressing wounds, and splinting the hand. A secondary survey involves assessing history, vascularity, muscles/tendons, soft tissue defects, fractures, and imaging. Informed consent is required. Reconstruction may use early or delayed approaches. Early approaches reconstruct skeletal stabilization, vascularity, nerves, tendons, and soft tissue within 72 hours. Wound excision is classified as tidy or untidy wounds. Skeletal stabilization uses plates or external fixation. Revascularization uses end-to-end anastomoses or grafts. Nerves are repaired or transferred. Tendon reconstruction is early for simple fractures but staged for
A skin graft involves surgically removing a patch of skin from one area of the body and transplanting it to another area. There are two main types of skin grafts: partial-thickness grafts which contain the epidermis and part of the dermis, and full-thickness grafts which contain the entire dermis. Skin grafts are used to treat large wounds, burns, ulcers, and other conditions where there has been significant skin loss or damage. Recovery from a skin graft procedure may take several weeks and involve dressing changes and restricted activity. While skin grafts are usually successful, complications can include infection, scarring, or only partial healing of the grafted area.
This document provides an overview of hand surgery basics including physical exam and anatomy, common injuries and conditions such as lacerations, fractures, arthritis, and carpal tunnel syndrome. Treatment approaches are discussed for various conditions including suturing of lacerations, splinting of fractures, surgical excision of ganglions, and carpal tunnel release surgery. Emerging treatments like platelet-rich plasma injections are also mentioned.
Here is a presentation I use for patients with heel conditions. It covers plantar fasciitis, plantar fibroma, Achilles tendonitis, Haglund's deformity, posterior tibial tendonitis, Severe's Disease. To learn more about heel pain go to www.worcesterfootcare.com/heel
Preventing falls and amputation prevention april 2013Donald Pelto
This document discusses ways to prevent falls and foot wounds for those with diabetes. It notes that falls are the leading cause of injury deaths among older adults, with hip fractures being most common. Risk factors for falls include neuropathy, ankle instability, weakness, vision problems, foot deformities, environmental hazards, and certain medications. It recommends developing a fall risk plan that includes assistive devices, therapy, medical care, and podiatric evaluation. The document also outlines 3.5 ways to prevent foot wounds: examining feet daily, wearing proper shoes, trimming calluses professionally, and taking responsibility through self-education and regular medical checks. Four major reasons wounds don't heal fast are listed as high blood sugar, poor circulation, neuropathy, and
This document contains a summary of a lecture on emergency medicine topics related to the foot and ankle. It discusses ingrown toenails, including when antibiotics are needed and when part or all of the nail should be removed. It also covers topics like heel pain, stress fractures, warts, ulcers versus calluses, Charcot, and provides contact information for the lecturer to learn more.
This document discusses flat feet and tendonitis in children, providing treatment recommendations over multiple visits including RICE, physical therapy, proper shoes, custom orthotics, and ankle foot orthoses (AFO) as needed. It was authored by podiatrist Donald Pelto and encourages learning more by visiting his website or contacting his office.
To learn more about diabetic foot wounds visit my website
www.healmyfootwoundfast.com
Educational power point on foot wounds relating to:
1. Obesity in America
2. The Epidemic of Diabetes
3. Complications of Diabetes
4. Cost Realities of Diabetes
5. Chronic Foot Ulcers
Dr. Donald Pelto
299 Lincoln Street Suite 202
Worcester, MA 01605
Healthcare Guide to Laser Treatment for Toenail FungusDonald Pelto
In this presentation you will discover:
2 - Ways to determine you have nail fungus
4 - Mistakes to avoid when treating nail fungus
4 - Step process for treating your fungal nails with laser therapy
This document discusses plantar fasciitis, a common cause of heel pain. It begins by explaining that plantar fasciitis is pain in the heel and arch of the foot, especially upon waking or with the first steps of the day. It then covers the typical symptoms of plantar fasciitis such as heel pain that is worst with the first steps and located inside the arch or central heel. The document discusses that plantar fasciitis is often caused by activities like running that put too much stress on the feet too quickly, hard surfaces, or old shoes without proper support. It concludes by outlining common treatment options for plantar fasciitis that can be done at home or in the doctor's office, such
Presentation of information for a comprehensive diabetic foot examination that is used in conjunction with the exam. Healthcare guide to diabetes and your feet can be obtained at www.drpelto.com
Emergency room presentation - Donald Pelto, DPMDonald Pelto
This document lists common types of foot and ankle injuries seen in emergency rooms, including fractures of the toes (phalanges and sesamoids), metatarsals, navicular, calcaneus, talus, and injuries to the Achilles tendon. It provides an overview of the different bone fractures and soft tissue injuries that podiatrist Donald Pelto treats at his practice in Worcester, MA.
This document summarizes various cold injuries and conditions including hypothermia. It discusses how the body loses heat and regulates core temperature. The signs and symptoms of mild, moderate, and severe hypothermia are provided. Treatment recommendations for hypothermia and other cold injuries like frostnip, frostbite, trench foot, and eye injuries are outlined.
El documento proporciona información sobre el cuidado de los pies en pacientes con diabetes. Detalla varias condiciones dermatológicas y musculoesqueléticas comunes en los pies de pacientes diabéticos como úlceras, callos, deformidades y fracturas. También describe tratamientos como desbridamiento de heridas, calzado terapéutico, inyecciones de esteroides y cirugía para estas afecciones. El objetivo es ayudar a los pacientes diabéticos a mantener sus pies saludables y prevenir complicaciones.
Unimed Presentation - Dr. Donald PeltoDonald Pelto
1. Diabetic foot ulcers are a common complication of diabetes, with an annual incidence of 1-4% and lifetime risk of 15-25%. Approximately 15% of diabetic foot ulcers result in lower extremity amputation.
2. Peripheral neuropathy is a major contributing factor in diabetic foot ulcers. The costs to treat a diabetic foot ulcer over a 2 year period following detection can be significant.
3. Five-year mortality rates for diabetes-related wounds and amputations are worse than some forms of cancer. Comprehensive diabetic foot examinations and appropriate footwear can help prevent ulcers.
Running form is key to avoiding foot pain. Maintaining a stable pelvis through engaged abdominal muscles prevents the upper body from leaning forward and reduces stress on the feet. Allowing the foot to land underneath the body in-line with proper form keeps the foot from overpronating and the toes from gripping the ground, avoiding injuries.
Common Foot Problems - Donald Pelto, DPMDonald Pelto
This document discusses common foot problems and their treatments. It covers issues like plantar fasciitis, ingrown toenails, bunions, hammertoes, Morton's neuroma, and plantar warts. For each problem, it describes symptoms, causes, diagnosis methods, and potential home, office-based, and surgical treatments. It aims to inform readers about these foot conditions and help them better understand and manage their symptoms.
The document discusses current treatments and advanced therapies for diabetic foot complications, outlining risk factors like neuropathy and vascular issues that can lead to foot ulcers, and describing approaches to managing dermatological issues, nerve damage, musculoskeletal problems, vascular challenges, and proper shoegear through treatments like VAC therapy, debridement, dermal substitutes, revascularization, and diabetic footwear modifications.
Dr. Donald Pelto discusses advances in preventing amputations for those with diabetes, noting that skin, nerves, bones, and blood vessels can be impacted. New treatments help wounds heal through synthetic skin substitutes, platelet-rich plasma therapy, and nail treatments. Advances also aid neuropathic feet through nerve fiber density tests, help manage Charcot foot through walking boots and surgery, and improve blood flow using devices like Silverhawk. Proper shoes, socks, and avoiding slippers can further reduce amputation risk.
Diagnosis and management by PCPs of simple podiatric problemsDonald Pelto
This document summarizes common podiatric issues that primary care physicians may diagnose and manage. It outlines treatments for conditions such as plantar fasciitis, flat feet, Morton's neuroma, bunions, callouses, athlete's foot, ingrown nails and diabetic foot ulcers. Evaluation and management may involve debridement, padding, orthotics, steroid injections, antibiotics, antifungals and wound care. Therapeutic shoes are recommended for diabetics with risk factors for foot ulcers.
The document discusses diabetic foot complications, including:
1) Diabetic foot ulcers affect 1-4% of diabetics annually and have a 15-25% lifetime risk, with 15% resulting in lower extremity amputation.
2) Risk factors for diabetic foot ulcers include peripheral neuropathy, a major contributing factor. Comprehensive foot exams assess dermatological, nerve, osseous, and vascular risks.
3) Current treatments include addressing dry skin, fungal infections, calluses, ulcers, and more through debridement, dressings, offloading, and advanced therapies like skin grafts and platelet-rich plasma.
Mercurius is named after the roman god mercurius, the god of trade and science. The planet mercurius is named after the same god. Mercurius is sometimes called hydrargyrum, means ‘watery silver’. Its shine and colour are very similar to silver, but mercury is a fluid at room temperatures. The name quick silver is a translation of hydrargyrum, where the word quick describes its tendency to scatter away in all directions.
The droplets have a tendency to conglomerate to one big mass, but on being shaken they fall apart into countless little droplets again. It is used to ignite explosives, like mercury fulminate, the explosive character is one of its general themes.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
DECLARATION OF HELSINKI - History and principlesanaghabharat01
This SlideShare presentation provides a comprehensive overview of the Declaration of Helsinki, a foundational document outlining ethical guidelines for conducting medical research involving human subjects.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com