The document outlines the PhD project aims of assessing stressors affecting impaired stream ecosystems in Northern Italy, focusing on physical-chemical alterations and biodiversity indicators such as macrobenthos. It details the multi-stressor approach and structure-function relationships through various research works, including the impact of oil and sewage spills on macroinvertebrate assemblages and the influence of leaf types on breakdown rates. The presentation emphasizes the need for a multi-scale analysis and the potential for integrating findings to inform river restoration efforts.