This study surveyed 797 people through Amazon Mechanical Turk to understand perceptions of e-cigarettes among smokers and non-smokers. The results showed that smokers (72%) were more likely than non-smokers (14%) to have tried e-cigarettes. Smokers perceived e-cigarettes as cheaper than cigarettes and more helpful for quitting smoking, while non-smokers held the opposite beliefs. The top reasons for smokers wanting to try e-cigarettes were for help quitting smoking, while non-smokers cited curiosity; concerns about safety and cost deterred smokers while non-smokers did not want to smoke. The findings suggest tailoring public health messages about e-cigarettes separately for smokers