MRC eMedLabl Stratified medicine theme overview
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overview of the MRC-eMedlab infrastructure development to support the MRC Stratified medicine programme
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LOVD & ITHANET: Synergies and plans under GG2020 - Carsten W Lederer
The document discusses plans to synergize LOVD and ITHANET databases and platforms under the Global Globin 2020 initiative. Key points:
- LOVD is a variant database with over 7,000 individuals and 18,500 variants currently focused on HBB. ITHANET is a complementary web platform.
- They aim to integrate the databases and platforms to allow seamless, disease-specific access to variant and clinical data, with visualizations.
- Challenges include deciding which data to include and how to design suggested fields for the genotype-phenotype database.
- Input is needed on how to best collect and integrate the data between the two systems to create an effective global database.
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ITHANET - Information and Database Portal for the Thalassaemias and other Hae...Human Variome Project
This document describes ITHANET, an online portal that aims to be a scientific and diagnostic tool for research and treatment of thalassemias and other hemoglobinopathies. The portal includes several main sections - a community section to connect researchers and organizations, an encyclopedia called IthaPedia with educational resources, and several databases and tools including IthaGenes for hemoglobin variations, IthaMaps with epidemiological data, and an HPLC tool to facilitate diagnosis. Future plans are described to expand existing databases and develop a new genotype-phenotype database and updated version of IthaMaps.AARSOTA Bio-Immunotherapy at Hope4Cancer Institute
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The document summarizes research from the American Gut Project, a crowdsourced research study that collected over 11,000 microbiome samples from people across the United States. The project analyzed samples from the gut, skin, and oral cavities to study the association between the human microbiome and various environmental factors like age, diet, and location. Key findings from analyzing a subset of samples from patients who provided multiple sample types include identifying correlations between bacterial species from different body sites using machine learning techniques. Preliminary conclusions suggest this analysis uncovered new insights into links between oral/gut bacteria and identified some unique microbiome profiles.
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An integrated approach to analyzing breast cancer at the proteomic and genomic level is presented using a cytometric readout. The approach analyzes fine needle aspirates to assess proteins, mRNA expression of HER2, and genomic integrity. Feasibility testing used a model system of mixed cell lines and analyzed 40 breast tumors and 10 normal tissues fixed in two solutions. The clinical performance relates to the model system and the cell-based assay could apply to xenograft models and circulating tumor cells.
Ualcan- user friendly portal to analyse TCGA RNA-seq data
Genomics data from The Cancer Genome Atlas (TCGA) project has led to the comprehensive molecular characterization of multiple cancer types. The large sample numbers in TCGA offer an excellent opportunity to address questions associated with tumo heterogeneity. Exploration of the data by cancer researchers and clinicians is imperative to unearth novel therapeutic/diagnostic biomarkers. Various computational tools have been developed to aid researchers in carrying out specific TCGA data analyses; however there is need for resources to facilitate the study of gene expression variations and survival associations across tumors. Here, we report UALCAN, an easy to use, interactive web-portal to perform to in-depth analyses of TCGA gene expression data. UALCAN uses TCGA level 3 RNA-seq and clinical data from 31 cancer types. The portal's user-friendly features allow to perform: 1) analyze relative expression of a query gene(s) across tumor and normal samples, as well as in various tumor sub-groups based on individual cancer stages, tumor grade, race, body weight or other clinicopathologic features, 2) estimate the effect of gene expression level and clinicopathologic features on patient survival; and 3) identify the top over- and under-expressed (up and down-regulated) genes in individual cancer types. This resource serves as a platform for in silico validation of target genes and for identifying tumor sub-group specific candidate biomarkers. Thus, UALCAN web-portal could be extremely helpful in accelerating cancer research. UALCAN is publicly available at http://ualcan.path.uab.edu.
Cell lines breast-project
This study analyzed over 70 breast cancer cell lines with various omics techniques to develop predictive signatures of drug response. Six major breast cancer subtypes were identified previously that respond differently to treatments. The study performed exome sequencing on 75 cell lines, RNA sequencing on 56 lines, and other molecular profiling. Machine learning methods were used to analyze associations between drug responses and pretreatment omics signatures. Preliminary results identified modules of co-associated features like drug response, expression, and mutations. Developing these predictive signatures could help inform precision treatment by matching patients to effective therapies.
Asthma epigenomics
This study developed methods to profile active and poised enhancers in naive and memory CD4+ T cells from healthy individuals and asthmatic patients. The researchers isolated naive and memory CD4 T cells and divided the memory cells by CCR4 expression. They performed RNA-seq and ChIP-seq to identify H3K4me2-associated regulatory regions. A total of 120 ChIP-seq assays were completed on these cells. Unsupervised clustering identified cell type-specific and disease-specific enhancers. The goal was to determine how transcription and epigenetic modifications differ between cell phenotypes and health conditions.
Recommended
LOVD & ITHANET: Synergies and plans under GG2020 - Carsten W Lederer
The document discusses plans to synergize LOVD and ITHANET databases and platforms under the Global Globin 2020 initiative. Key points:
- LOVD is a variant database with over 7,000 individuals and 18,500 variants currently focused on HBB. ITHANET is a complementary web platform.
- They aim to integrate the databases and platforms to allow seamless, disease-specific access to variant and clinical data, with visualizations.
- Challenges include deciding which data to include and how to design suggested fields for the genotype-phenotype database.
- Input is needed on how to best collect and integrate the data between the two systems to create an effective global database.
ITHANET - Information and Database Portal for the Thalassaemias and other Hae...
ITHANET - Information and Database Portal for the Thalassaemias and other Hae...Human Variome Project
This document describes ITHANET, an online portal that aims to be a scientific and diagnostic tool for research and treatment of thalassemias and other hemoglobinopathies. The portal includes several main sections - a community section to connect researchers and organizations, an encyclopedia called IthaPedia with educational resources, and several databases and tools including IthaGenes for hemoglobin variations, IthaMaps with epidemiological data, and an HPLC tool to facilitate diagnosis. Future plans are described to expand existing databases and develop a new genotype-phenotype database and updated version of IthaMaps.AARSOTA Bio-Immunotherapy at Hope4Cancer Institute
Learn more about how AARSOTA Bio-Immunotherapy integrates with Hope4Cancer's non-toxic cancer treatment strategies. Hope4Cancer's alternative cancer treatments reduces the toxic effects of prior chemo and radiation treatments while directly healing the cancer.
American gut microbiome-2
The document summarizes research from the American Gut Project, a crowdsourced research study that collected over 11,000 microbiome samples from people across the United States. The project analyzed samples from the gut, skin, and oral cavities to study the association between the human microbiome and various environmental factors like age, diet, and location. Key findings from analyzing a subset of samples from patients who provided multiple sample types include identifying correlations between bacterial species from different body sites using machine learning techniques. Preliminary conclusions suggest this analysis uncovered new insights into links between oral/gut bacteria and identified some unique microbiome profiles.
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An integrated approach to analyzing breast cancer at the proteomic and genomic level is presented using a cytometric readout. The approach analyzes fine needle aspirates to assess proteins, mRNA expression of HER2, and genomic integrity. Feasibility testing used a model system of mixed cell lines and analyzed 40 breast tumors and 10 normal tissues fixed in two solutions. The clinical performance relates to the model system and the cell-based assay could apply to xenograft models and circulating tumor cells.
Ualcan- user friendly portal to analyse TCGA RNA-seq data
Genomics data from The Cancer Genome Atlas (TCGA) project has led to the comprehensive molecular characterization of multiple cancer types. The large sample numbers in TCGA offer an excellent opportunity to address questions associated with tumo heterogeneity. Exploration of the data by cancer researchers and clinicians is imperative to unearth novel therapeutic/diagnostic biomarkers. Various computational tools have been developed to aid researchers in carrying out specific TCGA data analyses; however there is need for resources to facilitate the study of gene expression variations and survival associations across tumors. Here, we report UALCAN, an easy to use, interactive web-portal to perform to in-depth analyses of TCGA gene expression data. UALCAN uses TCGA level 3 RNA-seq and clinical data from 31 cancer types. The portal's user-friendly features allow to perform: 1) analyze relative expression of a query gene(s) across tumor and normal samples, as well as in various tumor sub-groups based on individual cancer stages, tumor grade, race, body weight or other clinicopathologic features, 2) estimate the effect of gene expression level and clinicopathologic features on patient survival; and 3) identify the top over- and under-expressed (up and down-regulated) genes in individual cancer types. This resource serves as a platform for in silico validation of target genes and for identifying tumor sub-group specific candidate biomarkers. Thus, UALCAN web-portal could be extremely helpful in accelerating cancer research. UALCAN is publicly available at http://ualcan.path.uab.edu.
Cell lines breast-project
This study analyzed over 70 breast cancer cell lines with various omics techniques to develop predictive signatures of drug response. Six major breast cancer subtypes were identified previously that respond differently to treatments. The study performed exome sequencing on 75 cell lines, RNA sequencing on 56 lines, and other molecular profiling. Machine learning methods were used to analyze associations between drug responses and pretreatment omics signatures. Preliminary results identified modules of co-associated features like drug response, expression, and mutations. Developing these predictive signatures could help inform precision treatment by matching patients to effective therapies.
Asthma epigenomics
This study developed methods to profile active and poised enhancers in naive and memory CD4+ T cells from healthy individuals and asthmatic patients. The researchers isolated naive and memory CD4 T cells and divided the memory cells by CCR4 expression. They performed RNA-seq and ChIP-seq to identify H3K4me2-associated regulatory regions. A total of 120 ChIP-seq assays were completed on these cells. Unsupervised clustering identified cell type-specific and disease-specific enhancers. The goal was to determine how transcription and epigenetic modifications differ between cell phenotypes and health conditions.
Pdx project
1) The study analyzed RNA from 79 patient-derived xenograft (PDX) mouse models of various cancer types (breast, lung, GI, ovarian, endometrial, leukemia) to identify tumor and stromal biomarkers.
2) Total RNA was extracted from the human tumor cells and mouse stromal cells in the PDX models. RNA sequencing data was generated and analyzed using the T-Bioinfo platform.
3) Unsupervised analysis identified specific stromal cell samples and corrected for batch effects. Cancer-specific samples were also identified for further investigation. The aim was to discover biomarkers for classifying tumor and stromal cells using this multi-cancer PDX mouse model RNA-seq
The BRCA Challenge & Exchange: Progress and Plans - Gunnar Rätsch
The BRCA Challenge aims to improve care for patients at risk of breast and ovarian cancer through global data sharing and collaboration on BRCA1 and BRCA2 variants. It plans to:
1) Share BRCA variants publicly via the BRCA Exchange portal, displaying a curated list of variants interpreted through expert consensus.
2) Address challenges of global data sharing through its organization structure and subcommittees.
3) Create a model for data sharing and analysis for all disease genes.
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This document provides a brief history of cancer research and treatment. It discusses three ages of cancer research: (1) from ancient times to 1838 which focused on cancer anatomy; (2) from 1838-2001 which centered around understanding cancer at the cellular level; and (3) from 1953 onward which examines cancer at the genetic and molecular levels. It also highlights recent advances in whole genome sequencing and molecular targeted therapies that have improved cancer survival rates.
In vivo animal testing
CAR-T cell preclinical in vivo animal testing performed in xenograft murine models derived by well-defined cell lines or primary human tumor cells. Immunodeficient mice, lacking of effective innate immunity for the absence of B cells, T cells, or NK cells, are the optimal animal models for engraftment of tumor cells and evaluation of CAR-T cells. https://www.creative-biolabs.com/car-t/car-t-preclinical-in-vivo-assay.htm
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This document summarizes a presentation on developing bioluminescent reporter T cells to analyze adoptive T cell transfer (ATT) in vivo. Key points:
- The researchers designed NFAT-driven luciferase and fluorescent protein reporter systems to monitor T cell migration, proliferation and activation after ATT.
- Testing in an H-Y antigen tumor model showed the reporters could detect T cell infiltration and transient activation in tumors, helping optimize ATT parameters.
- Various lentiviral and transgenic reporter constructs were developed and tested for sensitivity and balanced multi-color reporting of T cell responses.
2016 11-11_TSRI News Release
Macrophages, immune cells, may help tumors grow by forming primitive vascular channels. Researchers discovered that macrophages can create vessel-like structures in tumors to deliver oxygen and nutrients, representing a new potential cancer treatment target. The macrophage-formed conduits have a distinct architecture from blood vessels and appear too small for red blood cells, but may transport dissolved oxygen and glucose in oxygen-deprived tumor environments. Targeting macrophage activity in addition to current anti-angiogenesis drugs could provide a new approach to starving tumors.
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IUPHAR/MMV Guide to Malaria Pharmacology - BioMalPar XV
1) Researchers have created a new online resource called the IUPHAR/MMV Guide to Malaria Pharmacology (GtoMPdb) to curate information on antimalarial compounds and their molecular targets in Plasmodium.
2) The database currently contains 25 Plasmodium molecular targets and 57 antimalarial ligands that were manually curated from scientific literature.
3) A new customized online portal provides open access to the antimalarial data and allows browsing by parasite lifecycle stage, target species, and other features to help malaria research.
OncoPrime - Patient derived platform for Biologics research
“OncoPrime™ platform uses patient-derived primary samples that offer clinically-relevant genotypic and
phenotypic diversity that translates better to the clinic vis-à-vis cell lines.
Functional assays, when adapted to OncoPrime™ can not only help in claiming physiological relevance
but also add additional layers of information for more informed clinical trials.
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The key points are:
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- It uses an OpenStack cloud with an IBM-provided HPC cluster comprising over 100 servers and petabytes of storage.
- Several pilot projects are underway utilizing the infrastructure for tasks like genome analysis, integrating clinical data, and collaborative cancer genomics.
- Challenges include integrating support across institutions, ensuring security and performance when sharing storage, and addressing the differences between HPC and cloud computing models.
- Future plans
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Officetel charmington 181 cao thang - 0989040691
Charmington LaPointe – vị thế định thành công
Đáp ứng nhu cầu office-tel của hầu hết các doanh nghiệp trẻ hiện đại, Sacomeal - một chủ đầu tư uy tín trên thị trường sắp triển khai dự án Office - Tel tại vụ trí đắc địa - mặt tiền đường Cao Thắng nối dài.
Thông tin chi tiết Charmington LaPointe:
http://bit.ly/1SuV5kD
• Tên dự án: Charmington LaPointe
• Vị trí: 181 Cao Thắng, Phường 12, Quận 10, TPHCM
• Chủ đầu tư: Công ty cổ phần địa ốc Sài Gòn Thương Tín – Sacomreal
• Chủ thầu xây dựng: Toàn Thịnh Phát
• Diện tích dự án: 4997,8 m2
• Mật độ xây dựng: 40%
• Tổng số căn hộ: 470 căn gồm căn hộ và Officetel
• Số tầng hầm: 2 hầm
• Diện tích: từ 32m2
• Tầng thương mại: Officetel tại tầng 1
• Sân vườn: tầng 2
• Căn hộ văn phòng – Officetel: tầng 3 – 7
• Căn hộ dịch vụ: Tầng 8
• Khu căn hộ: Tầng 12 – 15
http://carillontanphu.com.vn/charmington-lapointe-officetel.html
http://bit.ly/1NTiWZu
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• Căn hộ Officetel Charmington LaPointe tọa lạc tại số 181 Cao Thắng, Phường 12, Quận 10, TPHCM. Đây là một vị trí đắc địa tại khu vực trung tâm Thành phố, dễ dàng kết nối với các quận trung tâm như Quận 1, 3, 5, Tân Bình, …
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Officetel charmington 181 cao thang - 0903789782
Officetel là từ viết gộp của cụm từ office (văn phòng) và Motel (căn hộ, nhà nghỉ), diện tích thiết kế từ 25 – 50m2.
Điểm đặc biệt của officetel:
+ Giá của những căn Charmington LaPointe officetel chỉ dao động từ trên dưới 1 tỷ VNĐ => do đó, loại hình căn hộ này rất được những người trẻ mới lập nghiệp, chưa có nhiều vốn, doanh nhân độc thân, người kinh doanh tự do hướng đến.
+ Thiết kế theo mô hình văn phòng làm việc hiện đại: có lối vào riêng, bảng tên công ty, sảnh lễ tân sang trọng, thang máy riêng, hệ thống an ninh tốt…
+ Người sở hữu officetel được phép nghỉ qua đêm, đăng kí tạm trú
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1) The study analyzed RNA from 79 patient-derived xenograft (PDX) mouse models of various cancer types (breast, lung, GI, ovarian, endometrial, leukemia) to identify tumor and stromal biomarkers.
2) Total RNA was extracted from the human tumor cells and mouse stromal cells in the PDX models. RNA sequencing data was generated and analyzed using the T-Bioinfo platform.
3) Unsupervised analysis identified specific stromal cell samples and corrected for batch effects. Cancer-specific samples were also identified for further investigation. The aim was to discover biomarkers for classifying tumor and stromal cells using this multi-cancer PDX mouse model RNA-seq
The BRCA Challenge & Exchange: Progress and Plans - Gunnar Rätsch
The BRCA Challenge aims to improve care for patients at risk of breast and ovarian cancer through global data sharing and collaboration on BRCA1 and BRCA2 variants. It plans to:
1) Share BRCA variants publicly via the BRCA Exchange portal, displaying a curated list of variants interpreted through expert consensus.
2) Address challenges of global data sharing through its organization structure and subcommittees.
3) Create a model for data sharing and analysis for all disease genes.
'THE ‘UNIQUENESS’ OF CANCER' by Professor David Thomas - Sick or Treat Sessions
This document provides a brief history of cancer research and treatment. It discusses three ages of cancer research: (1) from ancient times to 1838 which focused on cancer anatomy; (2) from 1838-2001 which centered around understanding cancer at the cellular level; and (3) from 1953 onward which examines cancer at the genetic and molecular levels. It also highlights recent advances in whole genome sequencing and molecular targeted therapies that have improved cancer survival rates.
In vivo animal testing
CAR-T cell preclinical in vivo animal testing performed in xenograft murine models derived by well-defined cell lines or primary human tumor cells. Immunodeficient mice, lacking of effective innate immunity for the absence of B cells, T cells, or NK cells, are the optimal animal models for engraftment of tumor cells and evaluation of CAR-T cells. https://www.creative-biolabs.com/car-t/car-t-preclinical-in-vivo-assay.htm
IUPHAR/MMV Guide to Malaria Pharmacology
Poster on IUPHAR/MMV Guide to Malaria Pharmacology presented at BPS Pharmacology 2018 (London, Dec 2018).
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This document summarizes a presentation on developing bioluminescent reporter T cells to analyze adoptive T cell transfer (ATT) in vivo. Key points:
- The researchers designed NFAT-driven luciferase and fluorescent protein reporter systems to monitor T cell migration, proliferation and activation after ATT.
- Testing in an H-Y antigen tumor model showed the reporters could detect T cell infiltration and transient activation in tumors, helping optimize ATT parameters.
- Various lentiviral and transgenic reporter constructs were developed and tested for sensitivity and balanced multi-color reporting of T cell responses.
2016 11-11_TSRI News Release
Macrophages, immune cells, may help tumors grow by forming primitive vascular channels. Researchers discovered that macrophages can create vessel-like structures in tumors to deliver oxygen and nutrients, representing a new potential cancer treatment target. The macrophage-formed conduits have a distinct architecture from blood vessels and appear too small for red blood cells, but may transport dissolved oxygen and glucose in oxygen-deprived tumor environments. Targeting macrophage activity in addition to current anti-angiogenesis drugs could provide a new approach to starving tumors.
MRC Stratified Medicine TranSMARTs
This document discusses MRC Stratified Medicine's use of TranSMART platforms to integrate and analyze data from various rheumatoid arthritis and psoriasis studies. It summarizes TranSMART's capabilities for data standardization, sharing compliant clinical data from studies like PSORT, MATURA, and RA-MAP. The document also outlines two potential models for secure data analysis and sharing - a "controlled data hub" allowing external analysis and an "analysis safe haven" conducting all analysis on a secure server. It acknowledges contributions from various organizations and looks ahead to evolving the infrastructure to provide more flexible computing resources and analysis capabilities.
Informa - Demonstrating Your PARP Inhibitor's Value
The document discusses making a business case for a PARP inhibitor drug in the ovarian cancer market. It provides information from various data sources on competitor drugs and clinical trials, the size of the ovarian cancer market, sales forecasts for Lynparza and other PARP inhibitors, and deal values that phase 1 oncology drugs and PARP inhibitors have achieved when licensed.
IUPHAR/MMV Guide to Malaria Pharmacology - BioMalPar XV
1) Researchers have created a new online resource called the IUPHAR/MMV Guide to Malaria Pharmacology (GtoMPdb) to curate information on antimalarial compounds and their molecular targets in Plasmodium.
2) The database currently contains 25 Plasmodium molecular targets and 57 antimalarial ligands that were manually curated from scientific literature.
3) A new customized online portal provides open access to the antimalarial data and allows browsing by parasite lifecycle stage, target species, and other features to help malaria research.
OncoPrime - Patient derived platform for Biologics research
“OncoPrime™ platform uses patient-derived primary samples that offer clinically-relevant genotypic and
phenotypic diversity that translates better to the clinic vis-à-vis cell lines.
Functional assays, when adapted to OncoPrime™ can not only help in claiming physiological relevance
but also add additional layers of information for more informed clinical trials.
Cancer Workflows in VarSeq
Clinical labs must have the ability to go from a collection of samples and associated variants to a professional report documenting a short list of clinically relevant variants. Cancer Gene Panels are a common clinical application for genetic tests. In this webcast we will show how VarSeq and VSReports can be used to go from an unfiltered variant file created by a secondary analysis pipeline to a report containing information about interesting variants.
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The BRCA Challenge & Exchange: Progress and Plans - Gunnar Rätsch
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Bruno Silva - eMedLab: Merging HPC and Cloud for Biomedical Research
This document discusses eMedLab, a project that merges HPC and cloud infrastructure for biomedical research.
The key points are:
- eMedLab provides a shared HPC and cloud environment across several UK biomedical institutions to enable data-driven medical research.
- It uses an OpenStack cloud with an IBM-provided HPC cluster comprising over 100 servers and petabytes of storage.
- Several pilot projects are underway utilizing the infrastructure for tasks like genome analysis, integrating clinical data, and collaborative cancer genomics.
- Challenges include integrating support across institutions, ensuring security and performance when sharing storage, and addressing the differences between HPC and cloud computing models.
- Future plans
CV Ramachandra
Ramachandra Rao is seeking a responsible position in a dynamic organization. He has over 15 years of experience in sales, operations, and administration roles. His career highlights include working as a regional sales executive for Inflow Technologies, an office executive for Edgewood Networks, and in sales coordination and product support roles for D-Link and Ingram Micro. He has strong computer skills and experience with SAP B1 and Oracle applications. Rao is organized, believes in teamwork, and desires to continuously learn and contribute to his employer.
Officetel charmington 181 cao thang - 0989040691
Charmington LaPointe – vị thế định thành công
Đáp ứng nhu cầu office-tel của hầu hết các doanh nghiệp trẻ hiện đại, Sacomeal - một chủ đầu tư uy tín trên thị trường sắp triển khai dự án Office - Tel tại vụ trí đắc địa - mặt tiền đường Cao Thắng nối dài.
Thông tin chi tiết Charmington LaPointe:
http://bit.ly/1SuV5kD
• Tên dự án: Charmington LaPointe
• Vị trí: 181 Cao Thắng, Phường 12, Quận 10, TPHCM
• Chủ đầu tư: Công ty cổ phần địa ốc Sài Gòn Thương Tín – Sacomreal
• Chủ thầu xây dựng: Toàn Thịnh Phát
• Diện tích dự án: 4997,8 m2
• Mật độ xây dựng: 40%
• Tổng số căn hộ: 470 căn gồm căn hộ và Officetel
• Số tầng hầm: 2 hầm
• Diện tích: từ 32m2
• Tầng thương mại: Officetel tại tầng 1
• Sân vườn: tầng 2
• Căn hộ văn phòng – Officetel: tầng 3 – 7
• Căn hộ dịch vụ: Tầng 8
• Khu căn hộ: Tầng 12 – 15
http://carillontanphu.com.vn/charmington-lapointe-officetel.html
http://bit.ly/1NTiWZu
http://bit.ly/1LUvSh1
http://bit.ly/1lbEpDA
• Căn hộ Officetel Charmington LaPointe tọa lạc tại số 181 Cao Thắng, Phường 12, Quận 10, TPHCM. Đây là một vị trí đắc địa tại khu vực trung tâm Thành phố, dễ dàng kết nối với các quận trung tâm như Quận 1, 3, 5, Tân Bình, …
• Phía Đông: nhìn về trung tâm Q1, công viên văn hóa Tao Đàn, nhà thờ Đức Bà, chợ Bến Thành, Dinh Độc Lập, tòa nhà Bitexco.
• Phía Nam: Đường 3/2 huyết mạch của Quận 10, nhìn về Nhà hát Hòa Bình, Học viện hành chính Quốc Gia, Việt Nam Quốc Tự.
• Phía Tây: nhìn về đường Sư Vạn Hạnh, trường Đại học ngoại ngữ Tin học, Kỳ Hòa Quán.
• Phía Bắc: mặt tiền đường Cao Thắng, nhìn về CMT8, Ga Sài Gòn
El color f ernanda
Este documento habla sobre la percepción del color y sus propiedades. Explica los tipos de colores como RGB, pigmentos y digitales. Luego describe las propiedades del color como matiz, tono y saturación. Finalmente, cubre las armonías de color como primarios, complementarios, fríos/cálidos, claro/oscuro y la calidad y cantidad.
HCD ESPOL
El documento presenta información en formato tabular sobre diferentes categorías y sus respectivos valores numéricos. También incluye términos sueltos como operadoras, ecuaciones matemáticas y nombres como Holi y Macka sin una explicación clara de su significado o relación.
Welcome to the Future
This short document promotes the creation of Haiku Deck presentations on SlideShare and encourages the viewer to get started making their own. It contains 4 stock photos with captions crediting their photographers and a call to action to get started creating a Haiku Deck presentation on SlideShare.
(A) circles i formulae
This document outlines key concepts about circles including identifying parts of circles, basic formulas for pi, circumference, and area, and further formulas related to radius. It separates the content into three main sections: identifying parts of circles, basic formulas including those for pi, circumference and area, and additional formulas related to radius.
Officetel charmington 181 cao thang - 0903789782
Officetel là từ viết gộp của cụm từ office (văn phòng) và Motel (căn hộ, nhà nghỉ), diện tích thiết kế từ 25 – 50m2.
Điểm đặc biệt của officetel:
+ Giá của những căn Charmington LaPointe officetel chỉ dao động từ trên dưới 1 tỷ VNĐ => do đó, loại hình căn hộ này rất được những người trẻ mới lập nghiệp, chưa có nhiều vốn, doanh nhân độc thân, người kinh doanh tự do hướng đến.
+ Thiết kế theo mô hình văn phòng làm việc hiện đại: có lối vào riêng, bảng tên công ty, sảnh lễ tân sang trọng, thang máy riêng, hệ thống an ninh tốt…
+ Người sở hữu officetel được phép nghỉ qua đêm, đăng kí tạm trú
+ Tiện ích của tòa nhà như tại khu căn hộ cao cấp: hồ bơi, phòng gym, khu mua sắm, thẩm mỹ, health care…
http://carillontanphu.com.vn/charmington-lapointe-officetel.html
Supercomputing and the cloud - the next big paradigm shift?
How can cloud technologies help us to address the challenges of re-use of research data and software and reproducibility of experiments? My slides from the University of Birmingham BEARcloud launch event, October 2016
Ch5(ms access with php)
This document provides examples of how to connect to and query a Microsoft Access database from PHP using ODBC. It demonstrates connecting to Access and performing basic CRUD (create, read, update, delete) operations as well as displaying results of a SELECT query in an HTML table. Specific connection strings and SQL statements for inserting, deleting, updating and selecting data from an Access table are shown.
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Bruno Silva - eMedLab: Merging HPC and Cloud for Biomedical Research
Bruno Silva - eMedLab: Merging HPC and Cloud for Biomedical Research
Supercomputing and the cloud - the next big paradigm shift?
Supercomputing and the cloud - the next big paradigm shift?
Similar to MRC eMedLabl Stratified medicine theme overview
Sfide della Oncologia Personalizzata
di Pier Giuseppe Pelicci, MD-PhD, Istituto Europeo di Oncologia IEO, Università degli Studi di Milano.
Slide per l'intervento tenuto in Fondazione Giannino Bassetti in occasione del primo incontro del ciclo "La medicina di precisione", primo progetto dalla convenzione tra Università di Pavia e Fondazione Bassetti.
12 marzo 2018
ACS Spring 2016 Combining semantic triple stores across knowledge domains
This presentation describes how semantic triple stores can be combined across knowledge domains to connect large datasets. Specifically, it discusses combining datasets on biological pathways, bioactivities, chemical structures and properties that were extracted from over 25 million documents through text mining. An example application presented is using this combined knowledge to find new indications for existing drugs by analyzing their targets and related diseases. The presentation concludes by demonstrating how the analysis approach identifies connections between the drug Ruxolitinib and alopecia, as well as potential treatments for congenital hyperinsulinism.
BCCT Showcase - chris buckley
This document summarizes research initiatives and facilities at the University of Birmingham focused on translating biomedical discovery into improved health. It outlines an integrated life sciences campus containing various research centers, institutes, and clinical facilities clustered around an Institute of Translational Medicine. Key areas of focus include chronic inflammatory disease, cancer, endocrinology/metabolism, and enabling digital technologies. Initiatives leverage nationally-funded centers for areas like arthritis, liver disease, and trauma to advance discovery science through clinical trials and implementation into patient care.
PRAVIN_D_POTDAR.pptx
This document discusses the importance of molecular diagnostics in the state of Maharashtra, India. It summarizes the speaker's experience establishing molecular diagnostic laboratories, the types of tests performed, and success stories. The speaker urges the Maharashtra government to provide basic accredited molecular diagnostic laboratories in all government hospitals and set up centralized facilities equipped for advanced molecular diagnostic testing. Establishing experienced molecular biologists to oversee the laboratories and conduct research is also recommended.
Mark Caulfield (Genomics England) - Understanding how genomics will transform...
Genomics England is sequencing 100,000 whole genomes from NHS patients to transform healthcare in the UK. This will help diagnose rare inherited diseases, cancers, and infectious pathogens. It will generate new treatments and establish the UK as a leader in genomic medicine. Rare disease diagnoses have already increased by 25-30% due to whole genome sequencing. In the future, genomics will be routinely used to deliver more precise therapies tailored to patients' genetic profiles.
EuroBioForum 2013 - Day 1 | Greame Boyle
EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013
=======================================
# NATIONAL PERSPECTIVES #
Scotland:
2b or not 2b – delivering Smart Clinical Trails
Graeme Boyle
Interim Director Stratified Medicine Scotland & Senior Programme Manager at Health Science Scotland
=======================================
http://www.eurobioforum.eu
iOMICS Clinical & Omnia
iOMICS Clinical & Omnia
Omics based (CDx)-drug-(Rx) solution
Asoke K Talukder, PhD & Mohamood Adhil
InterpretOmics
Real-World Evidence: The Future of Data Generation and Usage
As data is captured through electronic health records, registries and unique device identifiers, the generation of evidence based on this data is expected to play a crucial role in informing orthopedic manufacturers’ decisions before and after regulatory approval. While regulators, payors, hospitals and manufacturers support this shift, they acknowledge that gaps remain in its optimal execution. Priority considerations include how to generate evidence to expedite regulatory market decisions, device indication expansion, postmarket studies, postmarket surveillance and reimbursement decisions. The National Evaluation System for health Technology Coordinating Center (NESTcc), an initiative of the Medical Device Innovation Consortium (MDIC), is leading the conversation with various stakeholders, including FDA and orthopedic device companies to support the sustainable generation of Real-World Evidence (RWE) using Real-World Data (RWD).
Converged IT Summit - NCI Data Sharing
Cancer Moonshot, Data Sharing, Genomic Data Commons, NCI Cloud Pilots, Cancer Research Data Ecosystem, technology advances, chemotherapy advances, MATCH, NCI Cancer Moonshot Blue Ribbon Panel Recommendations
COTI Overview
CHEMSAS is a drug discovery platform that uses machine learning and algorithms to accelerate drug development and identify compounds with a higher likelihood of clinical success. ROSALIND is a smart data platform that analyzes a tumor's genetic profile and identifies potential treatment combinations tailored to restore normal cell signaling. Critical Outcome Technologies (COTI) is a clinical-stage biotech company focusing on novel cancer therapeutics discovered using CHEMSAS. COTI's lead candidates COTI-2 and COTI-219 are currently in clinical trials.
DOE-NCI Pilots presentation at the Frederick National Laboratory Advisory Com...
May 2016 FNLAC presentation of the DOE-NCI partnership around three pilots focused on existing projects in NCI and existing NSCI directives and activities in DOE.
National Cancer Data Ecosystem and Data Sharing
Grand Rounds at the Siteman Cancer Center at Washington University. Highlighting the Genomic Data Commons and the National Cancer Data Ecosystem defined by the Cancer Moonshot Blue Ribbon Panel
The way forward for greater manchester academic health science network ahsn
The document discusses the relationship between the Manchester Academic Health Science Centre (MAHSC) and the Greater Manchester Academic Health Science Network (GM-AHSN). It outlines that MAHSC members host many of the key assets that support GM-AHSN's business plan and that GM-AHSN's domains will deliver implementation of NICE guidelines and technologies. It also describes MAHSC and GM-AHSN's areas of expertise, including systems biology, discovery assets, implementation science, and access to a large population. Finally, it discusses opportunities and challenges for partnership working with industry through case studies.
The way forward for greater manchester academic health science network ahsn
The document discusses the relationship between the Manchester Academic Health Science Centre (MAHSC) and the Greater Manchester Academic Health Science Network (GM-AHSN). It outlines that MAHSC members host many of the key assets that support GM-AHSN's business plan and that GM-AHSN's domains will help implement NICE guidelines and technologies across Greater Manchester. It also provides examples of MAHSC's expertise in areas like systems biology, clinical research infrastructure, and implementation science. Finally, it discusses challenges like limited resources and the need for partnership between industry, academia, and the NHS to address issues like an aging population and chronic diseases.
MetaMax presentation for Skolkovo
The company develops innovative biopharmaceutical drugs using cell-penetrating peptides to target cancers. Its lead product, MM-D37K, is a chimeric peptide in preclinical testing for gastrointestinal cancers with the goals of receiving clinical trial approval and expanding indications. The company was founded in 2010, is privately held, and focuses on oncology with a technology platform of cell-penetrating peptides.
Cancer Moonshot, Data sharing and the Genomic Data Commons
Gave the inaugural Informatics Grand Rounds at City of Hope on September 8th. NIH Commons, Genomic Data Commons, NCI Cloud Pilots, Cancer Moonshot and rationale for changing incentives around data sharing all discussed.
1
This document discusses strategies for drug repurposing to treat COVID-19. It begins with an introduction to COVID-19 and issues with conventional drug development. It then covers drug repurposing approaches like in silico screening using molecular docking and dynamics simulations to identify existing drugs that may bind virus targets. Examples of drugs being repurposed for COVID-19 that are in clinical trials are mentioned, including remdesivir, hydroxychloroquine, and favipiravir. Overall strategies for drug repurposing including computational methods and examples of their application to COVID-19 are summarized.
Cardiology04 (1)
This document discusses developing a "cardiac moonshot" initiative using precision medicine approaches to more effectively treat heart disease. It outlines how precision medicine considers individual genetic and lifestyle factors. The initiative would leverage technologies like remote monitoring, wearables, and electronic health records to integrate diverse health data. This would allow more personalized treatment and risk prediction. Challenges include standardizing large data collection and educating medical professionals on complex multi-omic data analysis.
AORTIC Conference - The Continuous Update Project: Introduction to the Project
AORTIC Conference - The Continuous Update Project: Introduction to the ProjectWorld Cancer Research Fund International
Professor Martin Wiseman’s presentation, The Continuous Update Project: Introduction to the Project, at the African Organisation for Research & Training in Cancer (AORTIC) conference, 18-22 November 2015, Marrakech, Morocco.The Continuous Update Project: Introduction to the Project
Professor Martin Wiseman presentation on The Continuous Update Project: Introduction to the Project at FENS European Nutrition Conference, 20-23 October 2015 Berlin (Germany).
Similar to MRC eMedLabl Stratified medicine theme overview (20)
ACS Spring 2016 Combining semantic triple stores across knowledge domains
ACS Spring 2016 Combining semantic triple stores across knowledge domains
Mark Caulfield (Genomics England) - Understanding how genomics will transform...
Mark Caulfield (Genomics England) - Understanding how genomics will transform...
Real-World Evidence: The Future of Data Generation and Usage
Real-World Evidence: The Future of Data Generation and Usage
DOE-NCI Pilots presentation at the Frederick National Laboratory Advisory Com...
DOE-NCI Pilots presentation at the Frederick National Laboratory Advisory Com...
The way forward for greater manchester academic health science network ahsn
The way forward for greater manchester academic health science network ahsn
The way forward for greater manchester academic health science network ahsn
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AORTIC Conference - The Continuous Update Project: Introduction to the Project
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The Continuous Update Project: Introduction to the Project
Recently uploaded
The binding of cosmological structures by massless topological defects
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...Abdul Wali Khan University Mardan,kP,Pakistan
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skillsSAR of Medicinal Chemistry 1st by dk.pdf
In this presentation include the prototype drug SAR on thus or with their examples .
Syllabus of Second Year B. Pharmacy
2019 PATTERN.
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
学校原件一模一样【微信：741003700 】《(UAM毕业证书)马德里自治大学毕业证学位证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原。
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
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◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
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◇企事业单位必须要求办理的
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◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
ESR spectroscopy in liquid food and beverages.pptx
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Shallowest Oil Discovery of Turkiye.pptx
The Petroleum System of the Çukurova Field - the Shallowest Oil Discovery of Türkiye, Adana
Immersive Learning That Works: Research Grounding and Paths Forward
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
The technology uses reclaimed CO₂ as the dyeing medium in a closed loop process. When pressurized, CO₂ becomes supercritical (SC-CO₂). In this state CO₂ has a very high solvent power, allowing the dye to dissolve easily.
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
8.Isolation of pure cultures and preservation of cultures.pdf
Isolation of pure culture, its various method.
20240520 Planning a Circuit Simulator in JavaScript.pptx
Evaporation step counter work. I have done a physical experiment.
(Work in progress.)
Randomised Optimisation Algorithms in DAPHNE
Slides from talk:
Aleš Zamuda: Randomised Optimisation Algorithms in DAPHNE .
Austrian-Slovenian HPC Meeting 2024 – ASHPC24, Seeblickhotel Grundlsee in Austria, 10–13 June 2024
https://ashpc.eu/
Compexometric titration/Chelatorphy titration/chelating titration
Classification
Metal ion ion indicators
Masking and demasking reagents
Estimation of Magnisium sulphate
Calcium gluconate
Complexometric Titration/ chelatometry titration/chelating titration, introduction, Types-
1.Direct Titration
2.Back Titration
3.Replacement Titration
4.Indirect Titration
Masking agent, Demasking agents
formation of complex
comparition between masking and demasking agents,
Indicators/Metal ion indicators/ Metallochromic indicators/pM indicators,
Visual Technique,PM indicators (metallochromic), Indicators of pH, Redox Indicators
Instrumental Techniques-Photometry
Potentiometry
Miscellaneous methods.
Complex titration with EDTA.
Equivariant neural networks and representation theory
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero WaterTexas Alliance of Groundwater Districts
Presented at June 6-7 Texas Alliance of Groundwater Districts Business MeetingThe debris of the ‘last major merger’ is dynamically young
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
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The binding of cosmological structures by massless topological defects
The binding of cosmological structures by massless topological defects
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
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ESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptx
Immersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths Forward
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
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Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
8.Isolation of pure cultures and preservation of cultures.pdf
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20240520 Planning a Circuit Simulator in JavaScript.pptx
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Basics of crystallography, crystal systems, classes and different forms
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Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
Equivariant neural networks and representation theory
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Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
Sharlene Leurig - Enabling Onsite Water Use with Net Zero Water
The debris of the ‘last major merger’ is dynamically young
The debris of the ‘last major merger’ is dynamically young
MRC eMedLabl Stratified medicine theme overview
- 1. The eMedLab Stratified Medicine theme Michael Barnes (on Behalf of the eMedLab Exec and Tech Governance Group) UCL, Crick, QMUL, LSHTM, Sanger, EBI, KCL 19 10 2016 www.emedlab.ac.uk
- 2. • 13 internationally competitive stratified medicine discovery engines • Build on NIHR and DA clinical research funding • Total investment c. £60m • 3 charity co-funders (CRUK, ARUK, BHF) • 32 academic and 51 commercial partners MRC Stratified Medicine Consortia COPDMAP RAMAP-I MASTERMIND GAUCHERITE STOP-HCV MATURA-I UKPBC STRATA PSORT MASTERPLANS RASP-UK AIM HY S-CORT Auto-Immune Respiratory Cancer Infections Mental Health Cardiovascular Diabetes Congenital RAMAP-II MATURA-II
- 3. Cancer Research UK Stratified Medicine Programme – Key Metrics
- 4. Stratified Medicine in a Nutshell Omic (RNA, protein) Drug Response (Connectivity Map) Genetic Epigenetic Disease tissue Blood FACS TNF IL6 BAFF CD20 • Endotype1 • Endotype2 • Endotype3 Disease Endotype Adalimumab Rituximab • Anti-TNF • Anti-IL6 • Anti-CD20 Drug Endotype IL6 TNF BAFF CD20 BelimumabTocilizumab • Anti-TNF • Anti-IL6 • Anti-CD20 Response Biomakers Multi -Omics
- 5. What does success look like? +
- 6. eMedLab is a hub 7 partners Diverse data types electronic health records genomic images Diverse expertises clinician scientists analytics basic science £9M Hardware Investment 6048 cores 5.5PB storage Fast connections
- 7. Stratified Medicine Theme • 6 projects • 5 diseases • Common drugs • Common mechanisms
- 8. eMedLab VM architecture: MATURA • TranSMART and Command Line Analysis combined – Hosts TranSMART and command line queue system – Users access TranSMART by external web – Command line Access by VPN • Elastic computing on eMedLab – VM nodes are raised by Elastic Cluster and terminated when idle – Slurm queing system Head Queue Node 1 Node 2 Node n 12 cores 64GB RAM 32 cores 320GB RAM 32 cores 320GB RAM 32 cores 320GB RAM Elastic Compute VM nodes MATURA Head Server VPN login
- 9. eMedLab Embassy Data sharing Standards Meta-analysis Secure A Secure Collaboration Environment CHART Juvenile Idiopathic Arthritis TARGET Giant cell Arteritis SLERA RA Psoriasis VMVM VM VM VMVM Theme Academy
- 10. Meeting Aims • Share some great science • Brainstorm stratified medicine informatics challenges • Propose solutions • Feedback to MRC Stratified Medicine Strategy • Have fun
- 11. AGENDA Introduction to eMedLab – Nick Luscombe A Clinician’s Perspective on Stratified Medicine Challenges – Amy Foulkes PSORT : Defining And Studying Biologic Reponse– David Watson Cancer Stratified-Medicine Case Study – Bissan Al-Lazikani A Pharma perspective on Stratified Medicine Challenges– Anthony Rowe RA-Map: A Systems Biological Approach To Disease Stratification – Chris Johns Keynote: Interactive visualization of multi- omics data-- Simon Anders, FIMM Patient stratification using large-scale patient- level data – Nophar Geifman Panel Discussion – Computational challenges for Stratified Medicine Tea & Coffee