Translating discovery science into improved
health through technological innovation
An Integrated Life Sciences Campus
UHB QE Hospital
Future location Children’s Hospital
NIHR-WT CRF
Advanced Therapy Facility
Royal Centre Defence Medicine
Tr...
IBR

WM AHSN
PATIENT &
Adoption
POPULATION
Education
HEALTH
Clinical Trials
Digital Technology
Wealth Creation
Integrated ...
Focussed Research Strategy with
World Leading Outputs
CLINICAL ACADEMIC GROUPS
STRATIFIED MEDICINE
SCIENTIFIC
DISCOVERY

C...
Translational Research Underpinned by
Nationally Funded Centres
Chronic Inflammation
MRC CENTRE
IMMUNE
REGULATION

MRC-ARU...
Digital Technology Supports Excellence in Care

EDUCATION
SERVICE IMPROVEMENT
CLINICAL AUDIT

RESEARCH
Research Advances Embedded in Education
and Training to all Health Workers
• Clinical academic training
– Inspire student ...
The Institute of Translational Medicine (ITM)
- co-locating all components of an effective
translational infrastructure
• ...
Inflammation research in Birmingham
EATC
BEAT-RA
TRP’s

MRC Centre
Theme 3

Inflammation
Biology

MRC-ABPI

SSfH

CRF
IRF
...
The Birmingham Inflammation Group
CVS
Brain
e.g. MS
Teeth
Liver
Liver

Process
Driven
Pathology

Eye
Lung
Lung
Skin

Joint...
Inflammation Research Facility
CVS
Brain
e.g. MS
Teeth
Liver
Liver

Eye
Lung

Shared
Cohorts
And IT
(co-morbidity)

Lung
S...
Experimental Arthritis in Birmingham
• Unique stromal expertise
• Highly focused basic science and expanding early arthrit...
Operational Partnership
UHBFT Queen Elizabeth Hospital

Centre for Translational
Inflammation

Integrated clinical and lab...
Strategy for UK Life Sciences

UK wide strategy
• Reduce bureaucracy
• £310m for stratified medicine
and commercial resear...
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BCCT Showcase - chris buckley

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BCCT Showcase - chris buckley

  1. 1. Translating discovery science into improved health through technological innovation
  2. 2. An Integrated Life Sciences Campus
  3. 3. UHB QE Hospital Future location Children’s Hospital NIHR-WT CRF Advanced Therapy Facility Royal Centre Defence Medicine Trauma Research Centre Institute of Biomedical Research Centre for Translational Inflammation Research Institute Translational Medicine Medical School CRUK Cancer Centre Public Health Research Primary Care University of Birmingham
  4. 4. IBR WM AHSN PATIENT & Adoption POPULATION Education HEALTH Clinical Trials Digital Technology Wealth Creation Integrated Care CLAHRC DISCOVERY SCIENCE EFFECTIVENESS HEALTH ECONOMICS BHP IMPLEMENTATION CLINICAL TRIALS CLINICAL OBSERVATIONS EXPERIMENTAL MEDICINE CRC TU BCTU PCTU NIHR WT CRF
  5. 5. Focussed Research Strategy with World Leading Outputs CLINICAL ACADEMIC GROUPS STRATIFIED MEDICINE SCIENTIFIC DISCOVERY CLINICAL TRIALS SURGERY, DEVICES, DIAGNOSTICS ENABLING TECHNOLOGIES COMMERCIALISATION EDUCATION PATIENT & PUBLIC INVOLVEMENT CHRONIC INFLAMMATORY DISEASE CANCER ENDOCRINOLOGY & METABOLISM PATIENT BENEFIT REGIONAL DEVELOPMENT GLOBAL IMPACT
  6. 6. Translational Research Underpinned by Nationally Funded Centres Chronic Inflammation MRC CENTRE IMMUNE REGULATION MRC-ARUK CENTRE M-S AGEING ARUK RA CENTRE of EXCELLENCE NIHR BRU LIVER DISEASE NIHR TRP Joint and Inflammatory Disease NIHR Wellcome Trust CRF ARUK BEAT RA NIHR CLAHRC WM Endocrine & Metabolism Cancer CRUK CANCER CENTRE CRUK TRIALS UNIT ECMC LLR CENTRE EXPERIMENTAL CANCER CENTRE CLINICAL HEMATOLOGY TAP NIHR TRAUMA HTC NIHR TRC ENDOCRINE NEOPLASIA NIHR TRAUMA CENTRE HEALING FOUNDATION CENTRE FOR BURNS NIHR TRC RARE DISEASES CRUK Technology Hub ERDF Biomedical Innovation Hub NICE External Assessment Centre EPSRC Multidisciplinary Assessment of Technology Centre for Healthcare (MATCH)
  7. 7. Digital Technology Supports Excellence in Care EDUCATION SERVICE IMPROVEMENT CLINICAL AUDIT RESEARCH
  8. 8. Research Advances Embedded in Education and Training to all Health Workers • Clinical academic training – Inspire student programme – Royal College of Surgeons trainee programme – Clinical fellows embedded in NIHRWT CRF • New models – Empowering NHS Consultants to deliver research • Multidisciplinary – Allied Health Professionals – Common CPD, CME, e-learning platforms across BHP – Centre for Research in Medical & Dental Education
  9. 9. The Institute of Translational Medicine (ITM) - co-locating all components of an effective translational infrastructure • UK Government £12m • BHP £12m • To open June 2015 A UNIQUE TRANSLATIONAL FACILITY WITH STRATIFIED MEDICINE AT ITS CORE
  10. 10. Inflammation research in Birmingham EATC BEAT-RA TRP’s MRC Centre Theme 3 Inflammation Biology MRC-ABPI SSfH CRF IRF ARUK-MRC Ageing Centre for Translational Inflammation Research MRC Centre for Immune Regulation
  11. 11. The Birmingham Inflammation Group CVS Brain e.g. MS Teeth Liver Liver Process Driven Pathology Eye Lung Lung Skin Joint Joint Kidney Current Situation In Chronic Inflammation •Fragmentation •Duplication •Disease specific funding •Short term •Diagnosis to pathology Birmingham Inflammation Group •Integration •Multidisciplinary •Process specific funding •Durability •Pathology to Diagnosis
  12. 12. Inflammation Research Facility CVS Brain e.g. MS Teeth Liver Liver Eye Lung Shared Cohorts And IT (co-morbidity) Lung Skin Joint Joint Kidney Current Situation In Chronic Inflammation •Primary-secondary care split •No core data set •No information on co-morbidity •Lack of real world data IRF (supported by WT CRF) •Integration across 1ry and 2ry •Core data set •Respiratory, CVS, metabolic, periodontal •Within NHS Research Clinics
  13. 13. Experimental Arthritis in Birmingham • Unique stromal expertise • Highly focused basic science and expanding early arthritis cohorts • Direct access to patient tissue samples • Discrete stromal target discovery programmes • Multiple pre-clinical animal models • Internal and Industry therapeutic candidates Markers Epigenetics SSFH Protein expression In vitro function Periodontal cohort samples target discovery validation pre-clinical studies cohort: therapy
  14. 14. Operational Partnership UHBFT Queen Elizabeth Hospital Centre for Translational Inflammation Integrated clinical and laboratory space WTCRF satellite (IRF) NIHR Trauma Centre ARUK/MRC CoE in MSK ageing research ARUK EATC (BEAT-RA) Translational Research Partnership ARUK CoE in Pathogenesis of RA
  15. 15. Strategy for UK Life Sciences UK wide strategy • Reduce bureaucracy • £310m for stratified medicine and commercial research • Opt out for research data • Encourage industry engagement • Stimulate economic growth

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