This study examined the effects of a high-fat diet on metabolic health in mice. Mice fed a high-fat diet for 16 weeks developed obesity, insulin resistance, and nonalcoholic fatty liver disease compared to mice fed a normal diet. A high-fat diet was found to alter gut microbiota and bacterial metabolites in ways that may contribute to the development of metabolic diseases.

1. http://ajpendo.physiology.org/content/296/6/E1319.long<br />http://bloodjournal.hematologylibrary.org/cgi/content/full/114/10/2015<br />