This study evaluated quantitative ultrasound features for assessing hepatic fibrosis in a rat model of cirrhosis induced by diethylnitrosamine (DEN). Rats received DEN (n=12) or served as controls (n=4). Ultrasound images were analyzed for echo-intensity and heterogeneity at 0, 10, and 13 weeks. Both features increased significantly with time in DEN rats compared to controls. Histological analysis found DEN rats developed METAVIR grades F2-F4 fibrosis while controls were F0. Echo-intensity and heterogeneity correlated strongly with METAVIR grade. Ultrasound could non-invasively track fibrotic changes and distinguish fibrosis grades, suggesting potential for assessing liver fibrosis.