This document discusses modifiers 24 and 78 and how to determine if an evaluation and management (E/M) service provided during the global period of a procedure is unrelated or for complications. Modifier 24 is used if the E/M service is for an unrelated problem, while modifier 78 is used if the provider must return the patient to the operating room during the global period to treat complications. The definitions of unrelated may differ between payers, so providers need to check individual payer rules. Examples are given to illustrate the appropriate use of these modifiers.