Telomeres are repetitive sequence of nucleotides present at the end of the chromosomes. The main function of telomeres is to protect the ends of chromosomes from degradation and fusion. In normal cells, the telomere length decreases after each mitosis cycle, reaching a threshold limit after which the cell undergoes apoptosis. .

1. Open Journal of
Proteomics
Peertechz Journals

2. Review Article
miRNA Regulation of Telomerase: A
Novel Therapeutic Approach for Cancer
 Vivek Dhar Dwivedi*, Shiv Bharadwaj, Aman Chandra Kaushik
and Sarad Kumar Mishra
 *Corresponding author: Vibha Rani, Department of
Biotechnology, Jaypee Institute of Information Technology, A-
10, Sector-62, Noida, 210307, Uttar Pradesh, India, Tel: + (91)-
120-2594210; Fax: + (91)- 120-2400986;
 Dates: Received: 12 December, 2016; Accepted: 28 December,
2016; Published: 30 December, 2016
 Citation: Wahi T, Dargan S, Jaitly S, Rani V (2016) miRNA
Regulation of Telomerase: A Novel Therapeutic Approach for
Cancer. Open J Proteom 1(1): 013-018.

3. Abstract
 Telomeres are repetitive sequence of nucleotides present at the end of the
chromosomes. The main function of telomeres is to protect the ends of
chromosomes from degradation and fusion. In normal cells, the telomere
length decreases after each mitosis cycle, reaching a threshold limit after
which the cell undergoes apoptosis. Telomerase is over expressed in
approximately 85-90% of the tumors and thus it has become a lucrative
target as an anti-cancer therapeutic. In recent past, many therapies
targeting telomerase have been pursued, including immunotherapeutic
approaches, telomerase targeted gene therapy, and most recently
microRNAs telomerase vaccines, making them an attractive target for
cancer therapeutics. MicoRNAs (miRNAs) are 20-24 base pair non-coding
RNAs that regulate gene expression at post-transcriptional level. miRNAs
are important regulators of cancer and can be used to target telomerase,
thus acting as a therapeutic for cancer.In this review, we summarize the
possibility of broad-spectrum immunotherapy or even immunoprevention
and discuss therapeutic approaches based on small molecules to inhibit
telomerase activity. Also focusing on microRNA and how it controls the
expression of telomerase to prevent tumor development.

4. Thank you
For more information Read Online Article…
https://www.peertechz.com/articles/mirna-regulation-of-
telomerase-a-novel-therapeutic-approach-for-cancer.pdf
For
Full
Article
PDF