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The Michigan Difference
           in Vision




UNIVERSIT Y OF MICHIGAN KELLOGG EYE CENTER 2008 ANNUAL REPORT
Table of Contents

    RESEARCH
           New Use for Femtosecond Laser: Corneal Transplants . . . . . . . . . . . . . . . . . . . . . 5
           50 Years of Cornea Research at Kellogg . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6
           Early Warning for Diabetes Appears in Snapshot of Eye . . . . . . . . . . . . . . . . . . . 7
           Study Reveals Gaps in Glaucoma Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
           Consortium Puts Retinitis Pigmentosa under the Microscope . . . . . . . . . . . . . . . . . 9


    EDUCATION
           Iraq Veteran Hones Skills as Plastics Fellow . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
           RetinaDx Goes Live . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2
           Blueprint Drawn for 21st Century Resident Education Center . . . . . . . . . . . . . . 1 3
           Alums Care for Children Worldwide . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 4


    PATIENT CARE
    	      Surgery	Straightens	Toddler’s	Eyes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 7
           On the Road to Independent Living . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 8
           African Teen Has Long Overdue Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 9


    OUTREACH
           Big Ten Doctors Go to Vietnam . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 0


    GIVING
           Ravitz Professorship Honors Ophthalmic Pathology . . . . . . . . . . . . . . . . . . . . . . . 2 3
           Carls Foundation Ushers in New Era of Pediatric Eye Care . . . . . . . . . . . . . . . . 2 4
           Eye Center Expansion Makes Rapid Progress . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 5
           Kellogg Eye Center Expansion Honor Roll . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 6
           Towsley Foundation Supports Expanded Ophthalmic Imaging Center . . . . . . . 2 8
           Fralick Society Recognizes Annual Donors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9
           Chair Receives Top Ophthalmology Award . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9
           Annual Giving Honor Roll . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 0


    DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES FACULTY
    Faculty Honors, Recognition and Publications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 4
    Grants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 4
    Faculty Photos . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 8



                       2008 Annual Report • University of Michigan • W.K. Kellogg Eye Center
                             This report covers the period July 1, 2007 through June 30, 2008
Dear Friends,

                                       The year has been marked by rapid progress on the Kellogg Eye Center Expansion,
                                       many new faculty initiatives and research advances, and, as always, exceptional
                                       generosity on the part of those who support the Eye Center.
                                             In this report, we have the opportunity to highlight the Cornea Service and its
                                       contributions to the Department over many years. Among the foremost contribu-
                                       tors is Alan Sugar, M.D., nationally known for his leadership in that subspecialty.
                                       He is an expert on a complement of corneal disorders and surgeries, including
                                       corneal transplantation. He has served for many years as a medical director of the
                                       Michigan Eye-Banks, and is principal investigator for the Department’s arm of the
                                       Cornea Donor Study, a multi-center study sponsored by the National Eye Institute.
                                       Along with others of us, Dr. Sugar was in on early stages of discovery when the
                                       Department realized that an industrial laser, the femtosecond laser, could be used
for eye surgery. That research resulted in the commercialization of a new laser for refractive surgery. Now Dr. Sugar
and colleagues are investigating that laser’s use for corneal transplantation. Dr. Shahzad Mian leads a pilot study that
investigates the femtosecond laser in cutting corneal tissue for the surgery, and he reports early positive outcomes.
     The Department continues its strong, long-standing reputation for research on retina function and disease. Such
research has profound implications for understanding diseases that affect the vision of so many older individuals. As
part of a new program initiated by the Foundation Fighting Blindness, several Kellogg scientists and clinicians are
collaborating with colleagues from other institutions to create new treatments for retinitis pigmentosa, a disease that
results in progressive loss of vision. The collaborative nature of the study is an example of research models now in
favor among federal funding agencies.
     Pediatric ophthalmology at Kellogg has also grown at a record pace over the past several years. Far ahead of its
peers, the Department announced in 1985 the nation’s first endowed pediatric ophthalmology chair, held then and now
by Dr. Monte Del Monte. Since then we’ve added faculty and many more patients and today our children’s clinics are
filled nearly to capacity. When the Eye Center Expansion opens in 2010 we will have a new spacious clinic, thanks to
the Carls Foundation. Read about that organization’s generous support in this report.
     The recurring theme of growth, of course, is what has created the need for a new facility. And so this year, we
celebrate the progress made toward the completion of the Eye Center expansion. In late fall we gathered to celebrate
the completion of the steel structure and the traditional Topping Out ceremony. Before long the structure was com-
pletely enclosed. Now, as the clinics take shape inside and brick and glass appear outside, the new building is beginning
to resemble the models and renderings we have viewed for the past couple of years. Each phase of construction brings
us nearer to the day when we can realize our goal of having one of the finest, most advanced Eye Centers in the nation.
     So many individuals and organizations have supported our goals. Our new Fralick Society was formed to
recognize annual partners in giving. And organizations like the Towsley Foundation are helping us build and
name key components of the building.
     Take a minute, also, to run through the honor rolls in this report. We recognize and thank our supporters —
friends, alumni, faculty and staff — who are committed to the growth of the Eye Center and believe in the power
of its research programs to find new treatments for people with blinding eye disease.




Paul R. Lichter, M.D.
F. Bruce Fralick Professor and Chair
University of Michigan Department of Ophthalmology and Visual Sciences
Director, W.K. Kellogg Eye Center
Building on SucceSS
In 1985 the W.K. Kellogg Eye Center opened. This                 In the late 1990s, Chair Paul R. Lichter, M.D.,
ultra-modern eight-story building allowed us to expand      realized that we would outgrow this still seemingly
our research and education efforts and our ability to       brand new eye care facility. He commissioned a
care for patients needing advanced eye care. The            study and by 2005, the Regents of the University
new building also allowed us to bring our vision            of Michigan had approved plans for expansion.
research scientists to a facility where they could easily        When the U-M Kellogg Eye Center expansion
exchange ideas with clinicians, nurturing the concepts      opens in 2010, we expect that year’s tally of patient
of collaborative and translational research. That same      visits will approach 140,000. At the same time, the
year, 1985, the Eye Center employed 90 faculty and          numbers of faculty and staff will increase to accom-
staff. If you follow the expanding circles on the charts    modate our patients and the urgent need to accelerate
below, you’ll see that we grew — in patient visits          research efforts toward a cure for eye disease.
and in staff and faculty to serve them — beyond our
greatest expectations.




                                        2010 Projected Patient Visits:
                                                 139,303




                                                2005 Patient Visits:
                                                   119,915




                                                  1995 Patient Visits:
                                                      57,081




                                                                 1985 Patient Visits:




08
                                                                     36,852
2010 Expansion
                                                                                                                        230,000 sq. ft.
                           Growth in Patient Visits


                    1985 W.K. Kellogg Eye Center                   2010: 512 projected
                                                                                                              In the spring of 2010, all
                    Research Tower and Clinic Building
                                                                                                              clinics and surgical suites
                    147,442 sq. ft.
                                                                   2005: 410                                  will move into the new
                                                                                                              U-M Kellogg Eye Center
                                                                                                              expansion. Research
                                                                                                              laboratories will be located
                                                                   1995: 198
                                                                                                              in the Kellogg Research
                                                                                                              Tower (left) and in the upper
                                                                                                              floors of the new facility.
                                                                   1985: 90




                                                                                                                                    5% Eye Plastic Neuro


                           Faculty and Staff Growth
                                                                                                   Growth in research spurred the               1% Glau
                    since the W.K. Kellogg Center Opened
                        Gifts Toward the New Building                                              expansion of the Kellogg Eye Center.
                                                                                                   While our newRetina
                                                                                                                 6% building will enable
                                                                   2010: 512 projected
                                                                                                   us to accelerate efforts toward more
                                                                                                   effective treatments and cures for eye
     $5.7 million                                                  2005: 410                       disease, it will also provide space for
       to goal
                                                                                                   the growing number of individuals
                                                                                                           8% Contact Lens
                                                                                                                                   Department Growt
                                                                                                   seeking eye care. Patients, faculty,
                                                                                                                                    in clinics by 2010
                                $20 Million Goal                                                   staff, alumni, and the community have
                                                                   1995: 198
                                                                                                   generously supported the building
                                                                                                   campaign. Reaching our fundraising
                                                                                                             10% Photography
                                                                   1985: 90
                                                                                                   goals will ensure we can make the
                                                            $14.3 million
                                                               raised                              most of this unique moment in our
                                                                                                   history.




    Gifts Toward the New Building
                   Gifts Toward Research and Endowment                                      Gifts Toward the New Building
                                                                                                             Growth in Patient Visits




n    $4.5 million                                                      $5.7 million
       to goal                                                           to goal



             $20 Million Goal   $20 Million Goal                                                    $20 Million Goal




                                            $14.3 million   $15.5 million                                                          $14.3 million
                                               raised          raised                                                                 raised




                                                                                          UNIVERSITY OF MICHIGAN kellogg eye center           3
                                                                                         Gifts Toward Research and Endowment
Accelerating Research

Through collaboration and

individual effort, our scientists

are achieving new insights into

eye disease and treatment
strategies. Their goal is to bring

the best new therapies — and

hope — to our patients and

their families.




                                     Shahzad I. Mian, M.D.
“We hope that with the use of the femtosecond laser,
                    patients will have better vision, faster recovery of vision,
                              and stronger wound construction ...”
                                                                                                               — Shahzad I. Mian, M.D.




FEMTOSECOND LASER                                                Because of the speed and precision of the femto-
                                                            second laser, the study results to date for corneal trans-
COULD CHANGE CORNEAL                                        plant surgery have been very encouraging, according to
TRANSPLANT SURGERY                                          Dr. Mian. If these results hold true, a larger, multi-
                                                            center clinical trial comparing this procedure to the
Early results show laser — developed at
                                                            traditional method could follow.
U-M for eye surgeries — improving corneal                        The cornea is the clear, dome-shaped tissue cover-
transplant outcomes                                         ing the front of the eye. It is about the size of a dime
                                                            and the thickness of a credit card. If the cornea becomes
Nearly 15 years ago, researchers at Kellogg were first      distorted in shape, or scarred or hazy from disease or
to discover that the ultrafast or femtosecond laser, then   injury, the light rays passing through it are distorted
used for industrial purposes, had great potential for eye   and vision is reduced. In some cases, corneal transplant
surgeries that traditionally required a surgical blade.     surgery is necessary to replace the damaged cornea with
Faculty from Kellogg and the College of Engineering         a healthy donor cornea to restore good vision.
explored the laser’s surgical applications, and today it         Ophthalmologists perform more than 35,000 of
is used worldwide for LASIK surgery.                        these sight-saving procedures each year in the United
     Now, faculty hope for the same success in apply-       States and, of all transplant surgeries done today,
ing this exceptionally fast and precise laser to corneal    corneal transplants are the most common and most
transplant surgery.                                         successful. Donor corneas are provided by eye banks
     Physician–scientists at Kellogg are conducting a       and come from deceased individuals who arranged for
two-year pilot program — called the FLAK (Femtosec-         donation prior to death or whose families gave consent.
ond Laser-Assisted Keratoplasty) study — which uses
the femtosecond laser to perform full thickness corneal
transplants.
     “We hope that with the use of the femtosecond
laser, patients will have better vision, faster recovery
of vision, and stronger wound construction that will
provide more resistance to injury in the future,” says
Shahzad I. Mian, M.D., assistant professor and
Principal Investigator of the FLAK study.
     While lasers have been effective in eye surgeries
for decades, they were not used for corneal transplants
until the femtosecond laser was shown to be a supe-
rior cutting tool to the trephine, the cookie cutter-like
knife currently used for transplants. “The advantage
of this laser is that it allows the surgeon to focus the
laser energy at a particular depth and then rapidly cut
the tissue at that depth without causing any injury to
the surrounding tissue,” says Dr. Mian. “It also allows
the surgeon to pattern these cuts into shapes — such as
a mushroom, a top hat or a zig zag — that allow for
customized overlap between the donor’s corneal tissue
and the patient’s corneal tissue.”                                Corneal transplant patient, Gary Abud, with clinic coordinator, Satavisha Dutta.




                                                                                                             ACCELERATING research                   5
“This study indicates that corneas from older individuals
                                 are just as successful for corneal transplantation as
                                             those from younger donors.”
                                                                                                                                       — Alan Sugar, M.D.




                KEllogg’S	hiSTorical	rolE	
                IN CORNEAL TRANSPLANTATION
                Expanding the donor pool, improving
                success of transplants

                                                        For years, U-M Kellogg Eye
                                                        Center faculty have played
                                                        a significant role in corneal
                                                        transplantation. Kellogg
                                                        ophthalmologists helped to
                                                        establish the Michigan Eye-
                                                        Bank in 1957, which resided
                                                        in the Kellogg Eye Center
                                                        until 2006. Faculty members
                                                        have long collaborated with
                                                        the Eye-Bank on research.
                                                        In one recent example, Alan
                                                        Sugar, M.D., cornea surgeon
                                                                                              Dr. Shtein searches for ways to predict whether a cornea will be
                                                        and professor of ophthalmol-                            rejected after a transplant.
                                                        ogy, led the Kellogg arm of
Dr. Sugar led a team that studied age of cornea donors.
                                                        a national study on cornea      patients and interpret data.
                                                        donor tissue.                        At the same time, cornea specialist Roni M. Shtein,
                           The study, sponsored by the National Eye Institute           M.D., is looking at another important aspect of corneal
                    with tissue provided by the Midwest Eye-Banks, found                transplantation. One of the biggest concerns for patient
                    strong support for raising the age limit for donors. A              and physician is that the new tissue will be rejected. In
                    key finding of the study: the pool of corneal transplant            her study, Dr. Shtein will identify the characteristics of a
                    donors — often limited to those 65 years of age and                 patient’s cornea that could predict rejection of the new
                    younger — should be expanded to include donors up                   tissue. Specifically she will examine patterns of corneal
                    to 75 years of age.                                                 neovascularization — the growth of blood vessels in the
                           According to the Cornea Donor Study, the success             cornea — which is normally clear. In the first phase of
                    rate was the same whether the transplants were per-                 the study she will determine the best way to measure
                    formed with corneas from donors ages 12 to 65 years                 these patterns. In the next and larger portion of the
                    or from donors ages 66 to 75.                                       study, Dr. Shtein will develop ways to analyze charac-
                           “This study indicates that corneas from older                teristics of corneal neovascularization that can predict
                    individuals are just as successful for corneal transplan-           rejection or failure of the transplant.
                    tation as those from younger donors,” said Dr. Sugar.                    “This study is very specific in that it will allow us
                    He observes that in addition to expanding the pool of               to identify high risk blood vessels,” says Dr. Shtein.
                    cornea donors, the study will help surgeons learn more              “There is a great deal of interest now in medications
                    about the procedure itself. “The study team is analyzing            used to treat excessive blood vessels in retinal diseases
                    additional data that will help us understand more fully             like diabetic retinopathy and wet macular degeneration.
                    the factors involved in a successful cornea transplant,”            Perhaps these drugs, with some modification, could
                    he said. The Cornea Donor Study will continue for                   one day help reduce the risk of corneal transplant
                    another five years, allowing more time to follow                    rejection,” she adds.

     6      UNIVERSITY OF MICHIGAN kellogg eye center
SCREENING FOR DIABETES
WITH RETINAL IMAGING
“Snapshots” of the eyes may give early
warning of diabetes and related eye disease

A new vision screening device could give physicians and
patients a head start on treating diabetes and its vision
complications. The instrument, invented by two Kellogg                  Dr. Petty and Dr. Elner review data suggesting early signs of diabetes.
scientists, captures images of the eye that show meta-
bolic stress and the tissue damage that occur before the     is known to induce cell death in diabetic tissue soon
first symptoms of disease are evident. The camera-like       after the onset of disease but before symptoms can
instrument can detect this damage earlier than any cur-      be detected clinically. “Increased FA activity is the earli-
rent clinical method.                                        est indicator that cell death has occurred and tissue
     For people with diabetes — diagnosed or not — the       is beginning to break down,” says Dr. Petty.
new device could offer potentially significant advan-             People with diabetes might take better care of them-
tages over blood glucose testing, the “gold standard”        selves once they receive results from this kind of testing,
for diabetes detection. It is non-invasive and takes         suggests Dr. Petty. “A patient who understands that
about five minutes to scan both eyes. Used as a first-       body tissue is being destroyed may be newly motivated
line screening test, the device would indicate whether       to step up efforts to manage
a patient should proceed with additional testing.            the disease,” he says.
                                                                                                 “Technology that can
     In the July issue of Archives of Ophthalmology,              In the study, Drs. Elner
Victor M. Elner, M.D., Ph.D., and Howard R. Petty,           and Petty measured FA levels        detect the earliest signs
Ph.D., report on the potential of the new instrument         of 21 individuals with diabe-
to screen for diabetes.                                      tes and compared the results        of diabetes gives us a new
     “Technology that can detect the earliest signs of       to age-matched healthy
diabetes gives us a new way to tackle a growing public       controls. The Kellogg scien-        way to tackle a growing
health concern,” says Dr. Elner. “Early detection and        tists found that FA activity
                                                                                                 public health concern.”
treatment are critical in controlling the disease and its    was significantly higher for
many complications.” He points out that 24 million           those with diabetes, regard-        — VICTOR M. ELNER, M.D., PH.D.
Americans have diabetes and an additional 57 million         less of severity, compared to
have abnormal blood sugar levels that qualify as pre-        those who did not have the
diabetes. Some of these individuals will develop diabetic    disease. Similarly, individuals with diabetic retinopa-
retinopathy, an eye disease that affects 4.1 million         thy had much higher FA activity compared to diabetic
people and can cause blindness.                              patients without any visible eye disease.
     The instrument can detect metabolic stress, and              The study also suggests that FA levels can be
therefore disease, by measuring the intensity of cellular    used to monitor the severity of the disease and the
fluorescence in retinal tissue. This is the second study      ability of treatments to stem tissue damage.
in which Drs. Petty and Elner reported that high levels           Dr. Elner is a Research to Prevent Blindness Senior
of flavoprotein autofluorescence (FA) are reliable indica-   Scientific Investigator. The researchers have formed a
tors of eye disease.                                         company, OcuSciences, Inc., to commercialize the
     Dr. Petty, a biophysicist and imaging expert, ex-       metabolic imaging instrument.
plains that hyperglycemia — or high blood sugar —



                                                                                                            ACCELERATING research                 7
“As important as it is to look for new methods, if we just
                   concentrate on getting people to come for the treatments
                            we have, we can save a lot of vision.”
                                                                                                   — Joshua D. Stein, M.D., M.S.




        TRENDS IN HEALTH CARE
        EMERGE FROM CLAIMS DATA
        One troubling finding: many with
        glaucoma are not receiving treatment

       It appears that many older adults are not getting the
       treatment they need for a common form of glaucoma,
       according to a recent study. And perhaps more trou-
       bling, the data suggest that both nonwhite and low-
       income individuals are less likely to receive treatment.
            For glaucoma specialist and author of the study
       Joshua D. Stein, M.D., M.S., these numbers are dis-
       turbing. Prompt and sustained treatment is essential
                                   for preventing loss of vision
“There’s a wealth of               from glaucoma, a group of
                                   eye diseases causing damage          Dr. Stein crunched the numbers in a national database to learn more
information available              to the optic nerve. Once                                  about glaucoma treatment.
                                   damage occurs, vision loss
in these data sets. We             cannot be restored.             the data, make sense of the patterns, and, ultimately,
                                        The findings come from     use the information to improve care for our patients.”
just need to tap into
                                   an analysis of a database            The current study, published in Ophthalmology,
the data, make sense               with information on ser-        reported that nearly 30 percent of patients with glau-
                                   vices provided to Medicare      coma received neither medical nor surgical treatment.
of the patterns, and,              beneficiaries over a ten-year   Dr. Stein further observed that those with Medicaid, a
                                   period, from 1992 to 2002.      program for needy and low-income individuals, were 43
ultimately, use the
                                   Dr. Stein and his colleagues    percent less likely to receive care for glaucoma. Another
information to improve             identified 6400 individuals,    troubling statistic, he added, is that Hispanics, Asians
                                   all 65 years of age or older,   and patients from other minority groups were all less
care for our patients.”            who had received a diagno-      likely than non-Hispanic whites to receive treatment.
                                   sis of primary open-angle            Now, says Dr. Stein, we need further studies to
— JOSHUA D. STEIN, M.D., M.S.      glaucoma (POAG). The most       explain why these individuals aren’t receiving proper
                                   common form of glaucoma,        medical care. “Is access to health care the biggest
       POAG can silently and progressively destroy vision          problem, or is cost the obstacle? Perhaps there are bar-
       before symptoms are noticed.                                riers to communication,” he says. The answers to these
            The study is one of several of Dr. Stein’s research    questions could help more people with glaucoma get the
       projects in which he analyzes data from large health        care they need.
       care databases to flesh out patterns of health care. For         The study also examined which glaucoma drugs are
       example, by studying large groups he can determine          most frequently prescribed. And Dr. Stein says there is
       how frequently people use medical services, which med-      always debate about new and preferred treatments. But,
       ications are prescribed for them, which tests have been     he adds, “As important as it is to look for new glau-
       ordered, and other factors important in shaping health      coma therapies, if we could just concentrate on getting
       policy. “There’s a wealth of information available in       people to take advantage of the treatments we already
       these data sets,” he explains. “We just need to tap into    have, we would save a lot of vision.”

8    UNIVERSITY OF MICHIGAN kellogg eye center
CONSORTIUM SEEKS
ANSWERS ON RP
Is there more than one way to
rescue a photoreceptor?

Scientists and physicians from three universities are
teaming up to develop therapies for an inherited retinal
degenerative eye disease. Funded by the Foundation
Fighting Blindness (FFB), the project brings together the
best minds from various disciplines and perspectives
to collaborate on treatments for X-linked retinitis
pigmentosa (XLRP). A patient with XLRP has gener-
                                                                Hemant Khanna, Ph.D., John Heckenlively, M.D., David Zacks, M.D., Ph.D., (standing)
ously underwritten the research. Together the team will
                                                                and Naheed Khan, Ph.D., Debra Thompson, Ph.D., (seated) are on the Michigan team
explore a variety of therapeutic approaches, all intended                                studying retinitis pigmentosa.
to replace or rescue dying photoreceptors.
     Of the seven team members, five are from the U-M       the rods’ ability to function. This builds on the work
Kellogg Eye Center. Collaboration is becoming an            of Anand Swaroop, Ph.D., now a senior scientist at the
increasingly favored approach in research, says Debra       National Eye Institute, whose work at Kellogg led to
A. Thompson, Ph.D., who will direct one section of the      successful transplantation of rod precursor cells into
study. She points to recent results of a small study in     blind mice in 2006. Dr. Swaroop, whose lab identified a
which patients regained some vision after receiving gene    key mutation in the RPGR gene, was the driving force
therapy for a degenerative eye disease. “With this stun-    behind the creation of the Consortium.
ning success for patients with the RPE65 mutation, we            Taking another tack, researchers at the University
now have evidence that similar approaches could work        of Pennsylvania and the University of Florida will seek
for a larger group of patients whose vision is compro-      to repair photoreceptor damage by delivering thera-
mised by other genetic mutations.”                          peutic or “healthy” forms of the RPGR gene into the
     Retinitis pigmentosa is a group of diseases that       retina. They will investigate strategies using modified
cause slow but progressive loss of vision usually over      viruses that act as vectors to carry a replacement copy
decades. The designation “X-linked” means that the          of the affected gene. The replacement genetic material
mutation responsible for the disease is carried on the X    was constructed at Kellogg by Dr. Khanna’s laboratory.
chromosome. Simply stated, this disorder results in the          While gene delivery using viral vectors has been
loss of photoreceptors, the rods and cones responsible      successful in treating certain degenerative eye diseases,
for vision. Scientists who make up the FFB Consortium       Kellogg’s Dr. Thompson observes that there are still
will explore different strategies for restoring the func-   lingering concerns about the safety of the approach.
tion of photoreceptors and preventing their loss.           She is exploring alternate methods, involving the deliv-
     The project initially centers on a mouse model of      ery into the eye of small molecules expected to rescue
XLRP identified by Kellogg’s John R. Heckenlively,          failing photoreceptor physiology affected by the RPGR
M.D., in collaboration with the Jackson Laboratory.         mutation.
The model, known as rd9, has the same gene and type              Dr. Heckenlively, who sees patients with a range of
of mutations as seen in humans with XLRP.                   inherited retinal diseases, and whose project found over
     Using this mouse model, Hemant Khanna, Ph.D.,          100 mouse models of human eye disease, will evaluate
and David N. Zacks, M.D., Ph.D., will explore whether       the effectiveness of each approach. Dr. Heckenlively will
cell-replacement therapy is an effective strategy for       review fundus photographs and ERG recordings to see
restoring lost vision. They will transplant healthy pho-    how close each approach has come to the collective goal
toreceptor rods into the retinas of the diseased mice,      of rescuing photoreceptors.
with the goal of achieving at least partial recovery of
                                                                                                             ACCELERATING research                9
Investing in Education

By expanding our educational

and training programs, we

attract the best and brightest

residents, clinical fellows, and

postdoctoral research fellows.

They go on to careers in

ophthalmology and vision

science, serving as leaders here

and around the world.




                                   Christine C. Nelson, M.D. and Raymond Cho, M.D.
“I am particularly grateful for the time and effort which
                     all of the faculty continually invest in my development
                                   as an oculoplastic surgeon.”
                                                                                                                  — Raymond Cho, M.D.




KELLOGG FELLOW                                              undergraduate degree. The Ohio native went on to the
                                                            University of Cincinnati for medical school and com-
IS BATTLE TESTED                                            pleted his surgical internship at Brooke Army Medical
Physician who served in Iraq comes                          Center in San Antonio. He then spent three years in the
to Kellogg to hone his ophthalmic                           82nd Airborne Division at Fort Bragg, North Carolina.
                                                                 He returned to Brooke for his residency, after
plastic surgery skills
                                                            which he was assigned first to Fort Knox, Kentucky,
                                                            and later to West Point. As the only ophthalmologist at
Lieutenant Colonel Raymond Cho, M.D. served in Iraq
                                                            these military bases, Dr. Cho handled a variety of cases.
from November 2005 through April 2006. During that
                                                            “Working as the lone ophthalmologist taught me valu-
time, more than 90 percent of Dr. Cho’s patients were
                                                            able organizational skills and helped me build a strong
trauma victims — soldiers and civilians with ruptured
                                                            base in ophthalmology before moving on to a subspe-
eyes, facial fractures, and soft tissue trauma. After an
                                                            cialty,” says Dr. Cho.
intense time repairing eye damage caused by roadside
                                                                 When the military introduced its Warfighter Refrac-
bombs and improvised explosive devices, Dr. Cho came
                                                            tive Eye Surgery Program in 2001, Dr. Cho’s ophthal-
to Kellogg in 2007 to advance his clinical and surgical
                                                            mology repertoire expanded. He started a laser surgery
skills. He is now Kellogg’s fellow on the Eye Plastic,
                                                            program both at Fort Knox and at West Point.
Orbital and Facial Cosmetic Surgery Service.
                                                                 Once Dr. Cho completes his fellowship at Kellogg
     Kellogg’s fellowship programs, among the best
                                                            in 2009, he will go to one of the Army’s academic
in the nation, allow physicians to train in a clinical
                                                            medical centers to train residents and handle the oculo-
program known for depth and excellence in each sub-
                                                            plastics needs of the Army, including reconstructive
specialty. During the two-year oculoplastics program,
                                                            eye surgeries for soldiers returning from combat.
fellows gain extensive experience in diagnosis, surgical
management, pre- and postoperative care and manage-
ment of patients with eye plastic and orbital disorders
and diseases.
     “This fellowship at Kellogg has been a perfect fit
for me,” says Dr. Cho. “I am particularly grateful for
the time and effort which all of the faculty continually
invest in my development as an oculoplastic surgeon.
It has been an excellent program which will undoubt-
edly prepare me for the cases I will see in the future.”
That training has included unusual and complex cases
referred to Kellogg from far and wide.
     Dr. Cho’s mentors and colleagues at Kellogg are
quick to praise him. “He is a compassionate physician,
superb surgeon and has a humanitarian outlook,” says
Christine C. Nelson, M.D., associate professor. “He is
an inspiration to us all. His calm demeanor is refresh-
ing, he is a pleasure to work with, and he is a wonderful
teacher and mentor to the residents.”
                                                                 West Point graduate, Dr. Raymond Cho, served in Iraq before joining Kellogg
     Before coming to Kellogg, Dr. Cho chose to follow
                                                                               for his two-year ophthalmic plastics fellowship.
the path of his father and brother and enrolled in the
United States Military Academy at West Point for his


                                                                                                            INVESTING IN eDUcatIon             11
RETINADx GOES LIVE
         An educational web site also
         invites dialogue

        Looking back at their residency training, most
        ophthalmologists remember, somewhat fondly,
        the “fluorescein conference” as an effective way
        to learn about retinal diseases. At professional
        meetings, retina specialists have found the same
        kind of forum to be among the most popular
        and thought-provoking. Physicians present in-                 Dr. Zacks created a web program where doctors can review complex retinal cases,
        teresting cases of retinal disease and then engage                                      as well as submit their own.
        in animated discussions on possible diagnoses
        and treatments.                                                      An additional unforeseen benefit is the ease with
             David N. Zacks, M.D., Ph.D., a retina specialist at        which physicians will be able to collaborate on publica-
        the Kellogg Eye Center, is creating the same spirit on          tions. As clusters of cases on rare conditions appear
        a new web site — RetinaDx — with nearly 140 retina              on RetinaDx, the contributing doctors could seek out
        cases accompanied by spectacular images. For each case          each other and collaborate on case reports for ophthal-
        there is a brief history and presentation of findings, fol-     mology journals.
                                      lowed by retina photographs            The site has grown since fall 2005 when Dr. Zacks
                                      and diagnostic images and         first asked residents to submit cases during their rota-
 “So often physicians see             studies. In addition to the       tion in Kellogg’s Retina Clinic. As favorable feedback
                                      diagnosis and the differen-       came in, Dr. Zacks sought ways to make the site bigger
 a rare, isolated case and
                                      tial diagnosis, key teach-        and better. He reached out to his colleagues in other
 would benefit by talking             ing points — that is, “take       ophthalmology departments and has gathered an im-
                                      home” messages that can           pressive Advisory Board. With feedback from the Board
 with others who have                 be applied when the physi-        and users of the site, he expects RetinaDx to generate
                                      cian encounters patients          discussion and serve as a central gathering place for the
 encountered the same.”
                                      with similar symptoms — are       retina community.
 — DAVID N. ZACKS, M.D., PH.D.        included. Each case also has           Students, trainees and ophthalmologists are encour-
                                      a section where users can         aged to view the site and to join in the discussion by
                                      post their comments.              offering feedback and posting comments on cases at
             Dr. Zacks’ original intent was to create an educa-         www.kellogg.umich.edu/retinadx.
        tional site for medical students, residents and retina
        fellows. He believed that a comprehensive review of
        retina cases would be especially helpful during their
        training or when studying for Boards.
             But as the site evolved he envisioned yet another
        use — a forum where specialists could share insights
        and problem cases. “So often physicians see a rare,
        isolated case and would benefit by talking with others
        who have encountered the same,” he says. “Now they
        can submit the one-of-a-kind case and invite comments
        from their peers.”
                                                                            This fundus photograph shows the uncommon combination of choroidal
                                                                             neovascularization, angioid streaks and optic nerve head drusen that
                                                                                      led to the diagnosis of pseudoxanthoma elasticum.

12    UNIVERSITY OF MICHIGAN kellogg eye center
“We have one of the top residency programs in the country,
                              and enhancing our teaching environment
                                    will help us build on that.”
                                                                                                                                          — Shahzad I. Mian, M.D.




A CENTER FOR ExCELLENCE                                                                   •	 Laboratory	space	for	research	and	educational	
                                                                                             training
Kellogg expansion leads to dedicated,                                                     •	 A	residents	lounge	and	work	area	
high-tech space for residents                                                             •	 Close	proximity	to	Kellogg’s	John	W.	Henderson	
                                                                                             Library and to the residency program’s
With a goal of providing the best possible education to                                      administrative offices
future ophthalmologists, the Department’s residency                                       “The teaching part of this center, including the
training program is designing a new 2,000-square-foot                                surgical skills laboratory and surgery simulator, will be
center that will feature state-of-the-art educational and                            very helpful during all aspects of a resident’s training,”
communications technology as well as spaces to learn                                 says Sunir J. Garg, M.D., who completed his training at
and interact with colleagues.                                                        Kellogg in 2002 and now serves on the Department’s
     “This project will create a cohesive, comprehensive                             Alumni Advisory Board. He is an assistant professor of
space for resident education, and that’s important,” says                            ophthalmology at Wills Eye Hospital in Philadelphia.
Residency Director Shahzad I. Mian, M.D. “We have                                    “Faculty members always appreciate when residents
one of the top residency programs in the country, and                                invest time in their own surgical development and
enhancing our teaching environment will help us build on                             research efforts.”
that. We are bringing together resources and technology                                   The new center also includes a comfortable space
that will enable residents to get the most out of                                    for independent study or small group meetings as well as
their training here.”                                                                space for rest during on-call duty. The residents lounge
     The Resident Education Center, which will be housed                             will have a direct video link to Kellogg’s operating rooms,
on the sixth floor of the current Kellogg Eye Center                                 so residents can view surgeries at any time, without
tower, will include:                                                                 having to add traffic to the operating room environment.
     •	 A	large	conference	room	equipped	with	a	variety	                                  “Part of the experience of a residency is making
        of communication technologies and flexible fur-                              friends with your classmates, many of whom you will
        nishings that will accommodate conference table,                             see at meetings for the next 35 years,” Dr. Garg says.
        classroom, or lecture-style seating                                          “Having a place to congregate as a group, both to trade
     •	 A	surgical	skills	laboratory	and	surgery	simulator                           notes on diagnostic and surgical techniques, and to
     •	 A	pathology	teaching	laboratory	                                             have a chance to relax, makes training that much more
                                                                                     memorable.”




      Newly designed space for residents and fellows can be adapted for a variety of learning experiences and will include state-of-the-art instructional laboratories.
                                                                                                                                        INVESTING IN eDUcatIon            13
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                                                                                                                           seo Wei leo, M.D.
                                                                                                                                            bismus
                                                                                                                       hthalmology and Stra
                                                                                                 Head of Pediatric Op



                 apore
                                                                                                                                                up
                                                                                                     The Eye Institute, National Healthcare Gro
                                                                                                                                        Singapore



            Sing
                                                                                                                                          in 2005
                                                                                                                     Completed fellowship

                                                                                                           mplete a fellowship
                                                                                     e to Michigan to co
                                                            Co  ming from Singapor                          Dr. Leo because
                                                                                       er wasn’t easy for
                                                            at  the Kellogg Eye Cent                         cal and surgical
                                                                                      ly ties. But the clini
                                                            of   paperwork and fami                    more than worthwh
                                                                                                                              ile,
                                                            experience she gai  ned made the effort
                                                                                                           tric ophthalmology
                                                                                      e, she leads a pedia
                                                            sh  e says. In Singapor                           althcare Group, a
                                                                                         for the National He
                                                             an d strabismus service                s 3 million people. “
                                                                                                                         I enjoy
                                                             public health ca  re entity that serve                          y
                                                                                                       ung ones, who reall
                                                                                  pecially the very yo
                                                             helping patients, es                         to dia gnose and treat
                                                                                  or’s clinical acumen
                                                             depend on the doct                 holds an academic po
                                                                                                                       sition at
                                                                                   . Leo also
                                                              them,” she says. Dr
                                                                                    ity of Singapore.
                                                              the National Univers
Advancing Patient Care

Our patients have come to expect

exceptional care and access to

the newest and best treatments

for eye disease. At Kellogg they

will find doctors who are leaders

in their subspecialties and who

also have time to offer a smile

and words of encouragement.




                  Erika M. Levin, M.D.
GETTING IT STRAIGHTENED OUT
Pediatric ophthalmologist improves
the vision of Kellogg’s youngest patients

No parents want to hear that their child needs surgery.
However, when a child has strabismus — a visual disor-
der in which the eyes are misaligned and point in differ-
ent directions — sometimes surgery is the only treatment
that works. Such was the case for Derek and Rebecca
Najarian and their 21-month-old daughter, Olivia, from
Pinckney, Michigan.
     “It was the first surgery on our first child and we
were scared,” says Mrs. Najarian. “But Dr. Levin treated      Dr. Levin heard “proof positve” of the successful surgery. When Olivia and her parents
us well every step of the way. She answered every ques-            went to Disney World, her improved vision allowed Olivia to see Mickey Mouse
tion and explained each step of the process. We grew                            “jump” out of the 3-D movie and greet the children.
more and more comfortable, and, in the end, she really
put our minds at ease.”                                      early increases the chances of developing or regaining
     Erika M. Levin, M.D., a pediatric ophthalmologist       stereoscopic vision. If glasses aren’t effective, surgery —
at Kellogg, first saw Olivia in May 2003, when she was       or a combination of glasses and surgery — is recom-
just 16 months old. Olivia’s pediatrician noticed the        mended.
strabismus at her 15-month well-child visit and referred          In September 2003,
                                                             when Olivia was 21 months
                                                                                                   “It was the first surgery
her to Dr. Levin in Kellogg’s Brighton office.
     “When I first met Olivia, she was crying,” says         old, she underwent success-           on our first child and
Dr. Levin. “I wasn’t sure if she was nervous or scared,      ful strabismus surgery with
but we were able to work through the tears. I sang to        Dr. Levin repositioning her           we were scared. But
her, worked quickly and we got the job done.”                inner eye muscles. She went
     Even though Olivia was too young to read an eye         home the same day, with-              Dr. Levin treated us
chart, Dr. Levin was able to examine her using finger        out any special bandages
                                                                                                   well every step of the
puppets, mechanical toys and other equipment. Olivia         or patches, and returned to
had esotropia (inward turning of the eyes), amblyopia (a     normal activities within a            way, and, in the end,
“lazy eye” or poorly-seeing eye) and some far-sightedness.   few days. Two months later,
     Dr. Levin first recommended glasses because they        Olivia’s eyes were perfectly          she really put our minds
can sometimes help straighten the eyes in children with      aligned. Her amblyopia
                                                             hadn’t returned so she didn’t
                                                                                                   at ease.”
esotropia and farsightedness. This was not the case with
Olivia. Dr. Levin also patched Olivia’s stronger eye to      require further patching.
                                                                                                   — MS. REBECCA NAJARIAN
strengthen the vision in her weaker eye. Once her vision          Now, at 6 years old,
was equal and her misalignment was stable, Olivia was        Olivia sees 20/30 in each
ready for surgery.                                           eye without glasses and her eyes remain straight. She
     The goal in treating strabismus — a condition           returns to Kellogg once a year for a follow-up appoint-
affecting 4 percent of children in the United States —       ment, a visit Dr. Levin eagerly awaits.
is to straighten the eyes so they can be used together.           “One of the best things about being a pediatric oph-
With normal alignment, both eyes aim at the same spot.       thalmologist is seeing patients like Olivia grow and de-
When one eye is out of alignment, two different images       velop over the years,” says Dr. Levin. “It’s so rewarding
are sent to the brain. While adults would suffer from        to know that I’ve had a positive impact on my patients’
double vision, a child’s brain simply ignores the image      lives and on their families’ lives, too. I’m thrilled I can
from the misaligned eye. Correcting the misalignment         do that for them.”
                                                                                                              ADVANCING PatIent care                   17
THE ROAD TO INDEPENDENCE
        Low Vision Clinic helps patients make the
        most of their limited vision

        In 1992, Jeff Crawford came to the U-M Kellogg Eye
        Center’s Low Vision Clinic with one goal: he wanted to
        improve his vision so he could earn his driver’s license.
        He was tired of taking the bus or relying on family
        and friends to drive him where he needed to go. After
        working with low vision specialist Donna M. Wicker,
        O.D., Mr. Crawford achieved his goal and — at age
        28 — obtained his first license. He promptly bought a
        bright yellow Jeep Wrangler. “I figured that if I had
        any trouble seeing other drivers, at least they would
        be able to see me,” Mr. Crawford says, laughing.
             Kellogg’s Low Vision Clinic helps patients with
        vision loss ranging from mild impairment to legal
                                                                       Jeff Crawford credits Dr. Wicker for helping him live and work on his own terms.
        blindness. These people typically suffer from macu-
        lar degeneration, diabetic retinopathy, glaucoma and
        retinitis pigmentosa. Mr. Crawford is typical of many          ture telescopes attached to the top of his eyeglasses —
        patients with low vision — a term that denotes vision          to help him drive.
        that is 20/70 or less with the best conventional glasses            The low vision specialists see about 20 patients
        prescription.                                                  each week, most referred by Kellogg’s clinics and com-
             Many come to their first appointment with specific        munity offices. “Kellogg embraces a multi-disciplinary
        goals, such as improving their ability to tackle tasks         approach to the treatment of low vision,” explains
        like meal preparation, reading, driving, writing checks        Dr. Wicker. “We have a team of ophthalmologists,
        and paying bills.                                              optometrists and occupational therapists working
             “When patients come to our clinic, we discuss             together to meet each patient’s needs.”
        specific tasks they would like to accomplish or the ones            A low vision patient typically has one to four
        that give them trouble,” explains Dr. Wicker. “Our job         appointments. The last is an optional in-home visit
        then is to test their vision and optimize their remaining      by occupational therapist Karen Murphy, who helps
        functional vision with the use of optical devices, elec-       patients with lighting, safety, contrast and organization.
        tronic devices and training techniques.”                            Mr. Crawford, now 44, returns to Kellogg each
             What patients need most are devices that can mag-         year for a check-up with his ophthalmologist and sees
        nify the objects and material they encounter every day.        Dr. Wicker if his vision has changed.
        Among these are high-power reading glasses, telescopes,             “Dr. Wicker and the low vision staff are very pro-
        and handheld and stand magnifiers. Other devices               fessional and friendly and always are concerned about
        include special telephones and modified closed circuit         your well-being,” says Mr. Crawford. “The honesty
        televisions that enlarge reading material and project it       and integrity at Kellogg are phenomenal.”
        onto a TV monitor. Non-optical devices include large-               Thanks to Kellogg, Mr. Crawford can drive to his
        print items and talking clocks and watches.                    job of 14 years. He is a machine operator for Edwards
             It was the telescope that allowed Mr. Crawford to         Brothers, a book and journal manufacturing company
        get that first driver’s license. Because he is legally blind   in Ann Arbor.
        due to congenital cataracts and aniridia (an absent or              “Kellogg gave me back my freedom and indepen-
        partially absent iris), he uses bioptic telescopes — minia-    dence,” he states, proudly.


18   UNIVERSITY OF MICHIGAN kellogg eye center
RECONSTRUCTING THE ORBIT —                                  see the light at the end of the tunnel,” says Dr. Kahana.
                                                            Then Taiwo went on to see Gregory Dootz, Kellogg’s
and	a	Young	BoY’S	FuTurE                                    ocularist who has been creating and fitting prosthetic
Oculoplastics service built on teamwork,                    eyes for Kellogg patients for some 29 years.
tough cases                                                      One of three surgeons on Kellogg’s Eye Plastic,
                                                            Orbital and Facial Cosmetic Surgery service,
Taiwo Bilesanmi, now a teenager, lost his eye to cancer     Dr. Kahana credits his colleagues with having built
when he was just one year old and living in Nigeria. His    a strong practice that serves
family did not have access to a surgeon who could re-       as a major referral center for
build the child’s orbit, the bones and muscles that form    difficult eye plastic surgery.         “Orbital reconstruction
the eye’s support. The proper supporting structure was      Then too, there is the fore-
                                                            sight of recently retired ser-
                                                                                                   can be easy to do but
essential if Taiwo were, one day, to have a new pros-
thetic eye created for him.                                 vice chief, Bartley R. Frueh,          hard to do well.”
     Reconstructive surgery can make a big difference       M.D., who came to the
in people’s lives, observes Kellogg oculoplastic surgeon    Department to start the Eye            — ALON KAHANA, M.D., PH.D.
Alon Kahana, M.D., Ph.D. At first, Taiwo was too            Plastic Service nearly thirty
young to care about the loss of his eye, according to       years ago. One of his early
his father. But as he grew older, he became sensitive to    decisions was to hire Gregory Dootz, says Dr. Kahana.
comments from his friends about his appearance. By the      “Dr. Frueh was an accomplished surgeon who knew
time Taiwo came to the Kellogg Eye Center for orbital       that to do orbital reconstruction well it was essential
reconstruction, the young boy was anxious, but ready        to have an expert ocularist on staff and then work
for surgery that would allow him to have a new eye.         together as a team.”
Dr. Kahana was aware the surgery would not be simple.            Despite many doctor’s appointments and surgeries,
Taiwo, whose family now lives in Detroit, had gone for      Taiwo is very positive. His father offered strong encour-
some 12 years without an eye or prosthesis, and as a        agement, and Taiwo, now 15 years of age, says, “It was
result, the orbit had become malformed. Much of the         easy except for the surgery. It’s all OK now.”
supporting tissue was lost, and the bony structure had
grown inward, displacing a silicone implant from an
earlier surgery and making it impossible to fit a pros-
thetic eye.
     There was one more obstacle, this one concerned
with safety. Before Dr. Kahana would consider surgery,
he insisted that Taiwo begin to wear polycarbonate
glasses. Like his Kellogg colleagues, Dr. Kahana tells
his patients they must protect their “good” eye with
shatter-resistant lenses.
     Dr. Kahana then presented his plan: replace the ear-
lier implant with tissue from Taiwo’s thigh to create the
supporting structure. There are several techniques a sur-
geon can use to reshape the orbit, and many nuances in
performing the surgery, says Dr. Kahana. “The ultimate
goal is to have good reconstruction that is long lasting
and allows for a good prosthetic fit,” he says. “Orbital
reconstruction can be easy to do but hard to do well.”
     After surgery, Dr. Kahana was pleased at last to see
a smile on his patient’s face. “I think he finally could                 Taiwo Bilesanmi at a follow-up visit with Dr. Kahana.


                                                                                                         ADVANCING PatIent care   19
ON THE ROAD AGAIN
         Big Ten eye doctors go to Vietnam

         In March, five-year-old Vee, who lives in a small village
         outside Da Nang, Vietnam, had surgery to correct a
         tendency for his eyes to turn inward and upward. Vee’s
         surgeon was pediatric ophthalmologist Monte A. Del
         Monte, M.D., who had come to Vietnam with ORBIS,
         an organization that brings a Flying Eye Hospital and        Representatives from the Big Ten on the tarmack in Da Nang: Keith Carter, M.D.,
         ophthalmologists to countries where eye care and mod-            Derek Del Monte, M.D., Wanda Martinez, M.D., Monte Del Monte, M.D.,
         ern techniques are scarce.                                                              and Hua Gao, M.D., Ph.D.
              There was added commotion, as cameras followed
         Vee and Dr. Del Monte to film a televised special featur-    Dr. Del Monte. “But when we use this technique, we
         ing ophthalmologists from Big Ten universities teaching      see kids opening their eyes and smiling immediately
         local ophthalmologists and providing surgical treatment      after surgery. They have less pain, and they can be
                                      in developing countries.        outside playing the next day.”
                                      Michigan was represented             Sure enough, when Dr. Del Monte visited Vee in
 Training local doctors is            by Dr. Del Monte and            his home after the surgery, the young boy was doing
 vital in a country like              alumnus Keith C. Carter,        just fine, playing with a friend.
                                      M.D., who completed his              When not performing surgery, Dr. Del Monte
 Vietnam where just 10                residency at Kellogg and        lectured to ophthalmologists who had come from all
                                      today is chair of the Univer-   over the country. Again stressing its educational mis-
 ophthalmologists are                 sity of Iowa’s Department       sion, ORBIS asks volunteer physicians to bring several
                                      of Ophthalmology.               educational lectures when they travel.
 available per million
                                            By the end of the              Dr. Del Monte has participated in a number of
 people.                              week, Dr. Del Monte had         international programs, but this one had special mean-
                                      performed 15 surgeries on       ing for him. His son, Derek, who completed his medical
                                      children and adults with        training at Michigan and is now a first-year ophthal-
         strabismus, a condition in which the eyes are not            mology resident at Duke University, accompanied him
         properly aligned. His young patient Vee had a form           on the trip. “The experience sold him on the excitement
         of strabismus called esotropia with overacting inferior      and rewards of international ophthalmology, and in
         oblique muscles, causing inward turning or crossing and      a few years I expect to see him pursue the ORBIS
         vertical upshooting of his eyes, the most common con-        program for third-year residents.”
         dition Dr. Del Monte saw during his stay in Da Nang.              “One of the greatest rewards is that the families
              At the heart of ORBIS is the goal of training local     are so grateful,” adds Dr. Del Monte. “You know how
         doctors, nurses, and other health workers in state-of-       frightened the patients are before surgery, and then you
         the-art ophthalmic diagnostic and surgical techniques.       see big smiles on their faces after they become aware
         This is vital in a country like Vietnam where just 10        of the results.” Dr. Del Monte was especially touched
         ophthalmologists are available per million people.           by a unique personal gift he received from several of
              Assisted by a local ophthalmologist during Vee’s        his patients’ families: an intricately carved marble tray,
         surgery, Dr. Del Monte was able to demonstrate a new         dragon pitcher and matching cups, each engraved with
         surgical technique, a stitchless self-closing incision       the name of one of his surgical patients.
         underneath the eyelid in a way that eliminates external           Dr. Del Monte will be featured in a televised special
         stitches. “It is very comfortable for the patient, but       to air this fall. Check our web site for details.
         technically more difficult for the surgeon,” says


20    UNIVERSITY OF MICHIGAN kellogg eye center
“You know how frightened the patients are before surgery,
                          and then you see big smiles on their faces after they
                                    become aware of the results.”
                                                                                                                                     — Monte A. Del Monte, M.D.




Dr. Del Monte teaching local ophthalmologists in the O.R.          Five-year-old Vee before his surgery.                    Vee and his parents after his surgery.




                       Hua Imperial Palace, Hua, Vietnam.                                                         Sanpan water taxi, Hoi An, Vietnam.




                          Dr. Carter examines a patient’s x-ray.                                    Dr. Del Monte with his local trainees: Dr. Ngoc, Dr. Huang, and Dr. Tan.
Celebrating Philanthropy

     By endowing professorships,

     providing support for expansion,

     and making annual gifts

     to research, individuals and

     foundations are helping the

     Kellogg Eye Center reach new

     levels of excellence.




22    UNIVERSITY OF MICHIGAN kellogg eye center   Victor M. Elner, M.D., Ph.D.
ENDOWING A LEGACY
Ophthalmic pathologist Dr. Victor
Elner honored as Ravitz Foundation
establishes a professorship that
recognizes a little-known specialty

When Detroit native Edward Ravitz began a
Foundation to help improve the health of his
fellow citizens, he decided to support efforts
that sought good over glory, says Burton R.
Shifman, president of the Ravitz Foundation.
     Mr. Shifman and his fellow trustees fol-
                                                             Taking time to celebrate: Ravitz Foundation board members Lawrence F. Handler, M.D.,
lowed that mission in establishing the Ravitz
                                                                  Bruce D. Gelbaugh, Burton R. Shifman, and Arnold J. Shifman with Kellogg’s
Foundation Professorship in Ophthalmology and                   Paul R. Lichter, M.D., (center left) and Victor M. Elner, M.D., Ph.D. (center right).
Visual Sciences at the Kellogg Eye Center this year.
Victor M. Elner, M.D., Ph.D., is the first to hold the        art camera system that detects eye disease long before
professorship. His specialty of ophthalmic pathology          the first symptoms occur (see p. 7).
is essential to treating and understanding eye disease,            Dr. Elner’s clinical specialties include the evaluation
but it receives little notice. There are only ten ophthal-    and treatment of eyelid and orbital tumors, thyroid eye
mic pathologists in the U.S., working to identify the         disease and disorders affecting the eyelid and tear ducts.
correct source of disease.                                    He has published more than 150 articles on pathologic
     “In many ways, it’s a dying area of expertise, and       entities and advances in eye plastic surgery.
I commend the Ravitz Foundation for recognizing its                Mr. Ravitz, a businessman who oversaw the build-
importance and working to ensure it continues to              ing of more than 25,000 single-family homes and
benefit patients,” Dr. Elner says.                            apartments in Michigan and other states, would have
     As an ophthalmologist and a pathologist, Dr. Elner       appreciated the steady, groundbreaking progress Dr.
examines eye tissue to draw connections between the           Elner has made. From his hardworking immigrant
underlying disease process and the most effective ap-         parents, Mr. Ravitz learned ethics and responsibility.
proaches to diagnosis and treatment. He plays a central       He became a decorated combat army officer in World
role in training new ophthalmologists. “His appoint-          War II, after which he overcame many obstacles in
ment as Ravitz Professor will benefit both our Depart-        building a company that ultimately grew to 600 indi-
ment and the entire field of ophthalmology,” says             viduals. Though Mr. Ravitz passed away in 1999, his
Paul R. Lichter, chair of the U-M Department of               Foundation continues to pursue his vision of supporting
Ophthalmology and Visual Sciences.                            medical research and initiatives that eliminate prejudice
     Dr. Elner has been on the Kellogg faculty since          and further a sense of community and shared humanity.
1988. He received his medical degree, residency train-             At U-M, gifts from the Ravitz Foundation have
ing, and fellowship training in pathology from the            established a professorship in the U-M Department of
University of Chicago and completed additional fel-           Pediatrics and Communicable Diseases and the Ravitz
lowships in pathology and ophthalmic plastic and              Foundation Phase 1 / Translational Research Center at
reconstructive surgery. His research has shown that           the U-M Comprehensive Cancer Center. The Founda-
inflammation is often a cause of eye disease or its com-      tion has also supported C.S. Mott Children’s Hospital,
plications, and he has described the chain of events          the U-M Depression Center, the Medical School, the
that results in the destruction of cells leading to vision    School of Public Health, the Dental School, the Depart-
loss. He also collaborated with Kellogg scientist             ment of Molecular and Integrative Physiology, and the
Howard R. Petty, Ph.D., in developing a state-of-the-         Division of Kinesiology.

                                                                                                              CELEBRATING PhIlanthroPy                  23
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision
Michigan Difference in Vision

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Michigan Difference in Vision

  • 1. The Michigan Difference in Vision UNIVERSIT Y OF MICHIGAN KELLOGG EYE CENTER 2008 ANNUAL REPORT
  • 2. Table of Contents RESEARCH New Use for Femtosecond Laser: Corneal Transplants . . . . . . . . . . . . . . . . . . . . . 5 50 Years of Cornea Research at Kellogg . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Early Warning for Diabetes Appears in Snapshot of Eye . . . . . . . . . . . . . . . . . . . 7 Study Reveals Gaps in Glaucoma Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Consortium Puts Retinitis Pigmentosa under the Microscope . . . . . . . . . . . . . . . . . 9 EDUCATION Iraq Veteran Hones Skills as Plastics Fellow . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 RetinaDx Goes Live . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2 Blueprint Drawn for 21st Century Resident Education Center . . . . . . . . . . . . . . 1 3 Alums Care for Children Worldwide . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 4 PATIENT CARE Surgery Straightens Toddler’s Eyes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 7 On the Road to Independent Living . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 8 African Teen Has Long Overdue Surgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 9 OUTREACH Big Ten Doctors Go to Vietnam . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 0 GIVING Ravitz Professorship Honors Ophthalmic Pathology . . . . . . . . . . . . . . . . . . . . . . . 2 3 Carls Foundation Ushers in New Era of Pediatric Eye Care . . . . . . . . . . . . . . . . 2 4 Eye Center Expansion Makes Rapid Progress . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 5 Kellogg Eye Center Expansion Honor Roll . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 6 Towsley Foundation Supports Expanded Ophthalmic Imaging Center . . . . . . . 2 8 Fralick Society Recognizes Annual Donors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 Chair Receives Top Ophthalmology Award . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 9 Annual Giving Honor Roll . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 0 DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES FACULTY Faculty Honors, Recognition and Publications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 4 Grants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 4 Faculty Photos . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 8 2008 Annual Report • University of Michigan • W.K. Kellogg Eye Center This report covers the period July 1, 2007 through June 30, 2008
  • 3. Dear Friends, The year has been marked by rapid progress on the Kellogg Eye Center Expansion, many new faculty initiatives and research advances, and, as always, exceptional generosity on the part of those who support the Eye Center. In this report, we have the opportunity to highlight the Cornea Service and its contributions to the Department over many years. Among the foremost contribu- tors is Alan Sugar, M.D., nationally known for his leadership in that subspecialty. He is an expert on a complement of corneal disorders and surgeries, including corneal transplantation. He has served for many years as a medical director of the Michigan Eye-Banks, and is principal investigator for the Department’s arm of the Cornea Donor Study, a multi-center study sponsored by the National Eye Institute. Along with others of us, Dr. Sugar was in on early stages of discovery when the Department realized that an industrial laser, the femtosecond laser, could be used for eye surgery. That research resulted in the commercialization of a new laser for refractive surgery. Now Dr. Sugar and colleagues are investigating that laser’s use for corneal transplantation. Dr. Shahzad Mian leads a pilot study that investigates the femtosecond laser in cutting corneal tissue for the surgery, and he reports early positive outcomes. The Department continues its strong, long-standing reputation for research on retina function and disease. Such research has profound implications for understanding diseases that affect the vision of so many older individuals. As part of a new program initiated by the Foundation Fighting Blindness, several Kellogg scientists and clinicians are collaborating with colleagues from other institutions to create new treatments for retinitis pigmentosa, a disease that results in progressive loss of vision. The collaborative nature of the study is an example of research models now in favor among federal funding agencies. Pediatric ophthalmology at Kellogg has also grown at a record pace over the past several years. Far ahead of its peers, the Department announced in 1985 the nation’s first endowed pediatric ophthalmology chair, held then and now by Dr. Monte Del Monte. Since then we’ve added faculty and many more patients and today our children’s clinics are filled nearly to capacity. When the Eye Center Expansion opens in 2010 we will have a new spacious clinic, thanks to the Carls Foundation. Read about that organization’s generous support in this report. The recurring theme of growth, of course, is what has created the need for a new facility. And so this year, we celebrate the progress made toward the completion of the Eye Center expansion. In late fall we gathered to celebrate the completion of the steel structure and the traditional Topping Out ceremony. Before long the structure was com- pletely enclosed. Now, as the clinics take shape inside and brick and glass appear outside, the new building is beginning to resemble the models and renderings we have viewed for the past couple of years. Each phase of construction brings us nearer to the day when we can realize our goal of having one of the finest, most advanced Eye Centers in the nation. So many individuals and organizations have supported our goals. Our new Fralick Society was formed to recognize annual partners in giving. And organizations like the Towsley Foundation are helping us build and name key components of the building. Take a minute, also, to run through the honor rolls in this report. We recognize and thank our supporters — friends, alumni, faculty and staff — who are committed to the growth of the Eye Center and believe in the power of its research programs to find new treatments for people with blinding eye disease. Paul R. Lichter, M.D. F. Bruce Fralick Professor and Chair University of Michigan Department of Ophthalmology and Visual Sciences Director, W.K. Kellogg Eye Center
  • 4. Building on SucceSS In 1985 the W.K. Kellogg Eye Center opened. This In the late 1990s, Chair Paul R. Lichter, M.D., ultra-modern eight-story building allowed us to expand realized that we would outgrow this still seemingly our research and education efforts and our ability to brand new eye care facility. He commissioned a care for patients needing advanced eye care. The study and by 2005, the Regents of the University new building also allowed us to bring our vision of Michigan had approved plans for expansion. research scientists to a facility where they could easily When the U-M Kellogg Eye Center expansion exchange ideas with clinicians, nurturing the concepts opens in 2010, we expect that year’s tally of patient of collaborative and translational research. That same visits will approach 140,000. At the same time, the year, 1985, the Eye Center employed 90 faculty and numbers of faculty and staff will increase to accom- staff. If you follow the expanding circles on the charts modate our patients and the urgent need to accelerate below, you’ll see that we grew — in patient visits research efforts toward a cure for eye disease. and in staff and faculty to serve them — beyond our greatest expectations. 2010 Projected Patient Visits: 139,303 2005 Patient Visits: 119,915 1995 Patient Visits: 57,081 1985 Patient Visits: 08 36,852
  • 5. 2010 Expansion 230,000 sq. ft. Growth in Patient Visits 1985 W.K. Kellogg Eye Center 2010: 512 projected In the spring of 2010, all Research Tower and Clinic Building clinics and surgical suites 147,442 sq. ft. 2005: 410 will move into the new U-M Kellogg Eye Center expansion. Research laboratories will be located 1995: 198 in the Kellogg Research Tower (left) and in the upper floors of the new facility. 1985: 90 5% Eye Plastic Neuro Faculty and Staff Growth Growth in research spurred the 1% Glau since the W.K. Kellogg Center Opened Gifts Toward the New Building expansion of the Kellogg Eye Center. While our newRetina 6% building will enable 2010: 512 projected us to accelerate efforts toward more effective treatments and cures for eye $5.7 million 2005: 410 disease, it will also provide space for to goal the growing number of individuals 8% Contact Lens Department Growt seeking eye care. Patients, faculty, in clinics by 2010 $20 Million Goal staff, alumni, and the community have 1995: 198 generously supported the building campaign. Reaching our fundraising 10% Photography 1985: 90 goals will ensure we can make the $14.3 million raised most of this unique moment in our history. Gifts Toward the New Building Gifts Toward Research and Endowment Gifts Toward the New Building Growth in Patient Visits n $4.5 million $5.7 million to goal to goal $20 Million Goal $20 Million Goal $20 Million Goal $14.3 million $15.5 million $14.3 million raised raised raised UNIVERSITY OF MICHIGAN kellogg eye center 3 Gifts Toward Research and Endowment
  • 6. Accelerating Research Through collaboration and individual effort, our scientists are achieving new insights into eye disease and treatment strategies. Their goal is to bring the best new therapies — and hope — to our patients and their families. Shahzad I. Mian, M.D.
  • 7. “We hope that with the use of the femtosecond laser, patients will have better vision, faster recovery of vision, and stronger wound construction ...” — Shahzad I. Mian, M.D. FEMTOSECOND LASER Because of the speed and precision of the femto- second laser, the study results to date for corneal trans- COULD CHANGE CORNEAL plant surgery have been very encouraging, according to TRANSPLANT SURGERY Dr. Mian. If these results hold true, a larger, multi- center clinical trial comparing this procedure to the Early results show laser — developed at traditional method could follow. U-M for eye surgeries — improving corneal The cornea is the clear, dome-shaped tissue cover- transplant outcomes ing the front of the eye. It is about the size of a dime and the thickness of a credit card. If the cornea becomes Nearly 15 years ago, researchers at Kellogg were first distorted in shape, or scarred or hazy from disease or to discover that the ultrafast or femtosecond laser, then injury, the light rays passing through it are distorted used for industrial purposes, had great potential for eye and vision is reduced. In some cases, corneal transplant surgeries that traditionally required a surgical blade. surgery is necessary to replace the damaged cornea with Faculty from Kellogg and the College of Engineering a healthy donor cornea to restore good vision. explored the laser’s surgical applications, and today it Ophthalmologists perform more than 35,000 of is used worldwide for LASIK surgery. these sight-saving procedures each year in the United Now, faculty hope for the same success in apply- States and, of all transplant surgeries done today, ing this exceptionally fast and precise laser to corneal corneal transplants are the most common and most transplant surgery. successful. Donor corneas are provided by eye banks Physician–scientists at Kellogg are conducting a and come from deceased individuals who arranged for two-year pilot program — called the FLAK (Femtosec- donation prior to death or whose families gave consent. ond Laser-Assisted Keratoplasty) study — which uses the femtosecond laser to perform full thickness corneal transplants. “We hope that with the use of the femtosecond laser, patients will have better vision, faster recovery of vision, and stronger wound construction that will provide more resistance to injury in the future,” says Shahzad I. Mian, M.D., assistant professor and Principal Investigator of the FLAK study. While lasers have been effective in eye surgeries for decades, they were not used for corneal transplants until the femtosecond laser was shown to be a supe- rior cutting tool to the trephine, the cookie cutter-like knife currently used for transplants. “The advantage of this laser is that it allows the surgeon to focus the laser energy at a particular depth and then rapidly cut the tissue at that depth without causing any injury to the surrounding tissue,” says Dr. Mian. “It also allows the surgeon to pattern these cuts into shapes — such as a mushroom, a top hat or a zig zag — that allow for customized overlap between the donor’s corneal tissue and the patient’s corneal tissue.” Corneal transplant patient, Gary Abud, with clinic coordinator, Satavisha Dutta. ACCELERATING research 5
  • 8. “This study indicates that corneas from older individuals are just as successful for corneal transplantation as those from younger donors.” — Alan Sugar, M.D. KEllogg’S hiSTorical rolE IN CORNEAL TRANSPLANTATION Expanding the donor pool, improving success of transplants For years, U-M Kellogg Eye Center faculty have played a significant role in corneal transplantation. Kellogg ophthalmologists helped to establish the Michigan Eye- Bank in 1957, which resided in the Kellogg Eye Center until 2006. Faculty members have long collaborated with the Eye-Bank on research. In one recent example, Alan Sugar, M.D., cornea surgeon Dr. Shtein searches for ways to predict whether a cornea will be and professor of ophthalmol- rejected after a transplant. ogy, led the Kellogg arm of Dr. Sugar led a team that studied age of cornea donors. a national study on cornea patients and interpret data. donor tissue. At the same time, cornea specialist Roni M. Shtein, The study, sponsored by the National Eye Institute M.D., is looking at another important aspect of corneal with tissue provided by the Midwest Eye-Banks, found transplantation. One of the biggest concerns for patient strong support for raising the age limit for donors. A and physician is that the new tissue will be rejected. In key finding of the study: the pool of corneal transplant her study, Dr. Shtein will identify the characteristics of a donors — often limited to those 65 years of age and patient’s cornea that could predict rejection of the new younger — should be expanded to include donors up tissue. Specifically she will examine patterns of corneal to 75 years of age. neovascularization — the growth of blood vessels in the According to the Cornea Donor Study, the success cornea — which is normally clear. In the first phase of rate was the same whether the transplants were per- the study she will determine the best way to measure formed with corneas from donors ages 12 to 65 years these patterns. In the next and larger portion of the or from donors ages 66 to 75. study, Dr. Shtein will develop ways to analyze charac- “This study indicates that corneas from older teristics of corneal neovascularization that can predict individuals are just as successful for corneal transplan- rejection or failure of the transplant. tation as those from younger donors,” said Dr. Sugar. “This study is very specific in that it will allow us He observes that in addition to expanding the pool of to identify high risk blood vessels,” says Dr. Shtein. cornea donors, the study will help surgeons learn more “There is a great deal of interest now in medications about the procedure itself. “The study team is analyzing used to treat excessive blood vessels in retinal diseases additional data that will help us understand more fully like diabetic retinopathy and wet macular degeneration. the factors involved in a successful cornea transplant,” Perhaps these drugs, with some modification, could he said. The Cornea Donor Study will continue for one day help reduce the risk of corneal transplant another five years, allowing more time to follow rejection,” she adds. 6 UNIVERSITY OF MICHIGAN kellogg eye center
  • 9. SCREENING FOR DIABETES WITH RETINAL IMAGING “Snapshots” of the eyes may give early warning of diabetes and related eye disease A new vision screening device could give physicians and patients a head start on treating diabetes and its vision complications. The instrument, invented by two Kellogg Dr. Petty and Dr. Elner review data suggesting early signs of diabetes. scientists, captures images of the eye that show meta- bolic stress and the tissue damage that occur before the is known to induce cell death in diabetic tissue soon first symptoms of disease are evident. The camera-like after the onset of disease but before symptoms can instrument can detect this damage earlier than any cur- be detected clinically. “Increased FA activity is the earli- rent clinical method. est indicator that cell death has occurred and tissue For people with diabetes — diagnosed or not — the is beginning to break down,” says Dr. Petty. new device could offer potentially significant advan- People with diabetes might take better care of them- tages over blood glucose testing, the “gold standard” selves once they receive results from this kind of testing, for diabetes detection. It is non-invasive and takes suggests Dr. Petty. “A patient who understands that about five minutes to scan both eyes. Used as a first- body tissue is being destroyed may be newly motivated line screening test, the device would indicate whether to step up efforts to manage a patient should proceed with additional testing. the disease,” he says. “Technology that can In the July issue of Archives of Ophthalmology, In the study, Drs. Elner Victor M. Elner, M.D., Ph.D., and Howard R. Petty, and Petty measured FA levels detect the earliest signs Ph.D., report on the potential of the new instrument of 21 individuals with diabe- to screen for diabetes. tes and compared the results of diabetes gives us a new “Technology that can detect the earliest signs of to age-matched healthy diabetes gives us a new way to tackle a growing public controls. The Kellogg scien- way to tackle a growing health concern,” says Dr. Elner. “Early detection and tists found that FA activity public health concern.” treatment are critical in controlling the disease and its was significantly higher for many complications.” He points out that 24 million those with diabetes, regard- — VICTOR M. ELNER, M.D., PH.D. Americans have diabetes and an additional 57 million less of severity, compared to have abnormal blood sugar levels that qualify as pre- those who did not have the diabetes. Some of these individuals will develop diabetic disease. Similarly, individuals with diabetic retinopa- retinopathy, an eye disease that affects 4.1 million thy had much higher FA activity compared to diabetic people and can cause blindness. patients without any visible eye disease. The instrument can detect metabolic stress, and The study also suggests that FA levels can be therefore disease, by measuring the intensity of cellular used to monitor the severity of the disease and the fluorescence in retinal tissue. This is the second study ability of treatments to stem tissue damage. in which Drs. Petty and Elner reported that high levels Dr. Elner is a Research to Prevent Blindness Senior of flavoprotein autofluorescence (FA) are reliable indica- Scientific Investigator. The researchers have formed a tors of eye disease. company, OcuSciences, Inc., to commercialize the Dr. Petty, a biophysicist and imaging expert, ex- metabolic imaging instrument. plains that hyperglycemia — or high blood sugar — ACCELERATING research 7
  • 10. “As important as it is to look for new methods, if we just concentrate on getting people to come for the treatments we have, we can save a lot of vision.” — Joshua D. Stein, M.D., M.S. TRENDS IN HEALTH CARE EMERGE FROM CLAIMS DATA One troubling finding: many with glaucoma are not receiving treatment It appears that many older adults are not getting the treatment they need for a common form of glaucoma, according to a recent study. And perhaps more trou- bling, the data suggest that both nonwhite and low- income individuals are less likely to receive treatment. For glaucoma specialist and author of the study Joshua D. Stein, M.D., M.S., these numbers are dis- turbing. Prompt and sustained treatment is essential for preventing loss of vision “There’s a wealth of from glaucoma, a group of eye diseases causing damage Dr. Stein crunched the numbers in a national database to learn more information available to the optic nerve. Once about glaucoma treatment. damage occurs, vision loss in these data sets. We cannot be restored. the data, make sense of the patterns, and, ultimately, The findings come from use the information to improve care for our patients.” just need to tap into an analysis of a database The current study, published in Ophthalmology, the data, make sense with information on ser- reported that nearly 30 percent of patients with glau- vices provided to Medicare coma received neither medical nor surgical treatment. of the patterns, and, beneficiaries over a ten-year Dr. Stein further observed that those with Medicaid, a period, from 1992 to 2002. program for needy and low-income individuals, were 43 ultimately, use the Dr. Stein and his colleagues percent less likely to receive care for glaucoma. Another information to improve identified 6400 individuals, troubling statistic, he added, is that Hispanics, Asians all 65 years of age or older, and patients from other minority groups were all less care for our patients.” who had received a diagno- likely than non-Hispanic whites to receive treatment. sis of primary open-angle Now, says Dr. Stein, we need further studies to — JOSHUA D. STEIN, M.D., M.S. glaucoma (POAG). The most explain why these individuals aren’t receiving proper common form of glaucoma, medical care. “Is access to health care the biggest POAG can silently and progressively destroy vision problem, or is cost the obstacle? Perhaps there are bar- before symptoms are noticed. riers to communication,” he says. The answers to these The study is one of several of Dr. Stein’s research questions could help more people with glaucoma get the projects in which he analyzes data from large health care they need. care databases to flesh out patterns of health care. For The study also examined which glaucoma drugs are example, by studying large groups he can determine most frequently prescribed. And Dr. Stein says there is how frequently people use medical services, which med- always debate about new and preferred treatments. But, ications are prescribed for them, which tests have been he adds, “As important as it is to look for new glau- ordered, and other factors important in shaping health coma therapies, if we could just concentrate on getting policy. “There’s a wealth of information available in people to take advantage of the treatments we already these data sets,” he explains. “We just need to tap into have, we would save a lot of vision.” 8 UNIVERSITY OF MICHIGAN kellogg eye center
  • 11. CONSORTIUM SEEKS ANSWERS ON RP Is there more than one way to rescue a photoreceptor? Scientists and physicians from three universities are teaming up to develop therapies for an inherited retinal degenerative eye disease. Funded by the Foundation Fighting Blindness (FFB), the project brings together the best minds from various disciplines and perspectives to collaborate on treatments for X-linked retinitis pigmentosa (XLRP). A patient with XLRP has gener- Hemant Khanna, Ph.D., John Heckenlively, M.D., David Zacks, M.D., Ph.D., (standing) ously underwritten the research. Together the team will and Naheed Khan, Ph.D., Debra Thompson, Ph.D., (seated) are on the Michigan team explore a variety of therapeutic approaches, all intended studying retinitis pigmentosa. to replace or rescue dying photoreceptors. Of the seven team members, five are from the U-M the rods’ ability to function. This builds on the work Kellogg Eye Center. Collaboration is becoming an of Anand Swaroop, Ph.D., now a senior scientist at the increasingly favored approach in research, says Debra National Eye Institute, whose work at Kellogg led to A. Thompson, Ph.D., who will direct one section of the successful transplantation of rod precursor cells into study. She points to recent results of a small study in blind mice in 2006. Dr. Swaroop, whose lab identified a which patients regained some vision after receiving gene key mutation in the RPGR gene, was the driving force therapy for a degenerative eye disease. “With this stun- behind the creation of the Consortium. ning success for patients with the RPE65 mutation, we Taking another tack, researchers at the University now have evidence that similar approaches could work of Pennsylvania and the University of Florida will seek for a larger group of patients whose vision is compro- to repair photoreceptor damage by delivering thera- mised by other genetic mutations.” peutic or “healthy” forms of the RPGR gene into the Retinitis pigmentosa is a group of diseases that retina. They will investigate strategies using modified cause slow but progressive loss of vision usually over viruses that act as vectors to carry a replacement copy decades. The designation “X-linked” means that the of the affected gene. The replacement genetic material mutation responsible for the disease is carried on the X was constructed at Kellogg by Dr. Khanna’s laboratory. chromosome. Simply stated, this disorder results in the While gene delivery using viral vectors has been loss of photoreceptors, the rods and cones responsible successful in treating certain degenerative eye diseases, for vision. Scientists who make up the FFB Consortium Kellogg’s Dr. Thompson observes that there are still will explore different strategies for restoring the func- lingering concerns about the safety of the approach. tion of photoreceptors and preventing their loss. She is exploring alternate methods, involving the deliv- The project initially centers on a mouse model of ery into the eye of small molecules expected to rescue XLRP identified by Kellogg’s John R. Heckenlively, failing photoreceptor physiology affected by the RPGR M.D., in collaboration with the Jackson Laboratory. mutation. The model, known as rd9, has the same gene and type Dr. Heckenlively, who sees patients with a range of of mutations as seen in humans with XLRP. inherited retinal diseases, and whose project found over Using this mouse model, Hemant Khanna, Ph.D., 100 mouse models of human eye disease, will evaluate and David N. Zacks, M.D., Ph.D., will explore whether the effectiveness of each approach. Dr. Heckenlively will cell-replacement therapy is an effective strategy for review fundus photographs and ERG recordings to see restoring lost vision. They will transplant healthy pho- how close each approach has come to the collective goal toreceptor rods into the retinas of the diseased mice, of rescuing photoreceptors. with the goal of achieving at least partial recovery of ACCELERATING research 9
  • 12. Investing in Education By expanding our educational and training programs, we attract the best and brightest residents, clinical fellows, and postdoctoral research fellows. They go on to careers in ophthalmology and vision science, serving as leaders here and around the world. Christine C. Nelson, M.D. and Raymond Cho, M.D.
  • 13. “I am particularly grateful for the time and effort which all of the faculty continually invest in my development as an oculoplastic surgeon.” — Raymond Cho, M.D. KELLOGG FELLOW undergraduate degree. The Ohio native went on to the University of Cincinnati for medical school and com- IS BATTLE TESTED pleted his surgical internship at Brooke Army Medical Physician who served in Iraq comes Center in San Antonio. He then spent three years in the to Kellogg to hone his ophthalmic 82nd Airborne Division at Fort Bragg, North Carolina. He returned to Brooke for his residency, after plastic surgery skills which he was assigned first to Fort Knox, Kentucky, and later to West Point. As the only ophthalmologist at Lieutenant Colonel Raymond Cho, M.D. served in Iraq these military bases, Dr. Cho handled a variety of cases. from November 2005 through April 2006. During that “Working as the lone ophthalmologist taught me valu- time, more than 90 percent of Dr. Cho’s patients were able organizational skills and helped me build a strong trauma victims — soldiers and civilians with ruptured base in ophthalmology before moving on to a subspe- eyes, facial fractures, and soft tissue trauma. After an cialty,” says Dr. Cho. intense time repairing eye damage caused by roadside When the military introduced its Warfighter Refrac- bombs and improvised explosive devices, Dr. Cho came tive Eye Surgery Program in 2001, Dr. Cho’s ophthal- to Kellogg in 2007 to advance his clinical and surgical mology repertoire expanded. He started a laser surgery skills. He is now Kellogg’s fellow on the Eye Plastic, program both at Fort Knox and at West Point. Orbital and Facial Cosmetic Surgery Service. Once Dr. Cho completes his fellowship at Kellogg Kellogg’s fellowship programs, among the best in 2009, he will go to one of the Army’s academic in the nation, allow physicians to train in a clinical medical centers to train residents and handle the oculo- program known for depth and excellence in each sub- plastics needs of the Army, including reconstructive specialty. During the two-year oculoplastics program, eye surgeries for soldiers returning from combat. fellows gain extensive experience in diagnosis, surgical management, pre- and postoperative care and manage- ment of patients with eye plastic and orbital disorders and diseases. “This fellowship at Kellogg has been a perfect fit for me,” says Dr. Cho. “I am particularly grateful for the time and effort which all of the faculty continually invest in my development as an oculoplastic surgeon. It has been an excellent program which will undoubt- edly prepare me for the cases I will see in the future.” That training has included unusual and complex cases referred to Kellogg from far and wide. Dr. Cho’s mentors and colleagues at Kellogg are quick to praise him. “He is a compassionate physician, superb surgeon and has a humanitarian outlook,” says Christine C. Nelson, M.D., associate professor. “He is an inspiration to us all. His calm demeanor is refresh- ing, he is a pleasure to work with, and he is a wonderful teacher and mentor to the residents.” West Point graduate, Dr. Raymond Cho, served in Iraq before joining Kellogg Before coming to Kellogg, Dr. Cho chose to follow for his two-year ophthalmic plastics fellowship. the path of his father and brother and enrolled in the United States Military Academy at West Point for his INVESTING IN eDUcatIon 11
  • 14. RETINADx GOES LIVE An educational web site also invites dialogue Looking back at their residency training, most ophthalmologists remember, somewhat fondly, the “fluorescein conference” as an effective way to learn about retinal diseases. At professional meetings, retina specialists have found the same kind of forum to be among the most popular and thought-provoking. Physicians present in- Dr. Zacks created a web program where doctors can review complex retinal cases, teresting cases of retinal disease and then engage as well as submit their own. in animated discussions on possible diagnoses and treatments. An additional unforeseen benefit is the ease with David N. Zacks, M.D., Ph.D., a retina specialist at which physicians will be able to collaborate on publica- the Kellogg Eye Center, is creating the same spirit on tions. As clusters of cases on rare conditions appear a new web site — RetinaDx — with nearly 140 retina on RetinaDx, the contributing doctors could seek out cases accompanied by spectacular images. For each case each other and collaborate on case reports for ophthal- there is a brief history and presentation of findings, fol- mology journals. lowed by retina photographs The site has grown since fall 2005 when Dr. Zacks and diagnostic images and first asked residents to submit cases during their rota- “So often physicians see studies. In addition to the tion in Kellogg’s Retina Clinic. As favorable feedback diagnosis and the differen- came in, Dr. Zacks sought ways to make the site bigger a rare, isolated case and tial diagnosis, key teach- and better. He reached out to his colleagues in other would benefit by talking ing points — that is, “take ophthalmology departments and has gathered an im- home” messages that can pressive Advisory Board. With feedback from the Board with others who have be applied when the physi- and users of the site, he expects RetinaDx to generate cian encounters patients discussion and serve as a central gathering place for the encountered the same.” with similar symptoms — are retina community. — DAVID N. ZACKS, M.D., PH.D. included. Each case also has Students, trainees and ophthalmologists are encour- a section where users can aged to view the site and to join in the discussion by post their comments. offering feedback and posting comments on cases at Dr. Zacks’ original intent was to create an educa- www.kellogg.umich.edu/retinadx. tional site for medical students, residents and retina fellows. He believed that a comprehensive review of retina cases would be especially helpful during their training or when studying for Boards. But as the site evolved he envisioned yet another use — a forum where specialists could share insights and problem cases. “So often physicians see a rare, isolated case and would benefit by talking with others who have encountered the same,” he says. “Now they can submit the one-of-a-kind case and invite comments from their peers.” This fundus photograph shows the uncommon combination of choroidal neovascularization, angioid streaks and optic nerve head drusen that led to the diagnosis of pseudoxanthoma elasticum. 12 UNIVERSITY OF MICHIGAN kellogg eye center
  • 15. “We have one of the top residency programs in the country, and enhancing our teaching environment will help us build on that.” — Shahzad I. Mian, M.D. A CENTER FOR ExCELLENCE • Laboratory space for research and educational training Kellogg expansion leads to dedicated, • A residents lounge and work area high-tech space for residents • Close proximity to Kellogg’s John W. Henderson Library and to the residency program’s With a goal of providing the best possible education to administrative offices future ophthalmologists, the Department’s residency “The teaching part of this center, including the training program is designing a new 2,000-square-foot surgical skills laboratory and surgery simulator, will be center that will feature state-of-the-art educational and very helpful during all aspects of a resident’s training,” communications technology as well as spaces to learn says Sunir J. Garg, M.D., who completed his training at and interact with colleagues. Kellogg in 2002 and now serves on the Department’s “This project will create a cohesive, comprehensive Alumni Advisory Board. He is an assistant professor of space for resident education, and that’s important,” says ophthalmology at Wills Eye Hospital in Philadelphia. Residency Director Shahzad I. Mian, M.D. “We have “Faculty members always appreciate when residents one of the top residency programs in the country, and invest time in their own surgical development and enhancing our teaching environment will help us build on research efforts.” that. We are bringing together resources and technology The new center also includes a comfortable space that will enable residents to get the most out of for independent study or small group meetings as well as their training here.” space for rest during on-call duty. The residents lounge The Resident Education Center, which will be housed will have a direct video link to Kellogg’s operating rooms, on the sixth floor of the current Kellogg Eye Center so residents can view surgeries at any time, without tower, will include: having to add traffic to the operating room environment. • A large conference room equipped with a variety “Part of the experience of a residency is making of communication technologies and flexible fur- friends with your classmates, many of whom you will nishings that will accommodate conference table, see at meetings for the next 35 years,” Dr. Garg says. classroom, or lecture-style seating “Having a place to congregate as a group, both to trade • A surgical skills laboratory and surgery simulator notes on diagnostic and surgical techniques, and to • A pathology teaching laboratory have a chance to relax, makes training that much more memorable.” Newly designed space for residents and fellows can be adapted for a variety of learning experiences and will include state-of-the-art instructional laboratories. INVESTING IN eDUcatIon 13
  • 16. . zona an, M.D s Pachtm hael a. diatric Eye Speciali na st Mic Ari A rizona Pe Mesa, Arizo 1982 dency in Comp leted resi o his rive to d tman’s d as its roots Dr. Pach atients h e best for p says. “We wer rbor, he strive to in Ann A stantly d to con el of ca l re in en courage hest lev he hig essiona provide t ionate and prof art- a compa ss anaging p Toda y the m ac- manner.” roup pr ysician g ner of a 9-ph pediatric lizes in tice th at specia dult str abis- olo gy and a ud that ophthalm achtman is pro lty mus, Dr . P ubspecia tice makes s re easily his prac phthalmic ca ic o izona, pediatr en in Ar rnia le t o childr conomic accessib of their socioe lif o s regardles ion status. igrat Ca or imm Jenn ifer simp Chie Adult f of Pedia Assoc son, M. Unive Strabismus tric Ophth te Profes . ia D rsity o , and almolo sor f Cali Resid gy an Rest fo e Comp rnia Ir vine ncy Directo d or has a ing or leted Eye In r fellow n imp prese ship in stitute patie rvin nts, act that g vis 1999 says and t lasts ion in ch D hat a ildren alums care for children tor a r. Simps ’s extrem lifetime t the on. A ely re for Eye I U s w Worldwide nstit niversity residency arding, make ute, t she i of Califo direc- Dr. S hat kind s tra in rnia I imps o r residents and fellows who train at ing h on cr f differe ing others vine er bu edits nce a to in he il K s the kellogg eye center see a wide r gro d a stron ellogg wi well. enviro wing g res th he n de ide lp range of challenging pediatric cases. for p ment wit partment ncy prog - a h su . “ ea ram provi tient care ch h L rning the experience enables them to gain ded m , edu igh s in an to bu e wit c tan i h a t ation, and dards the skills they need to treat childhood says. ld my ow empl ate f teaching In ad n clinic dition academic rom eye diseases in rural and urban al du ties, to he pract which involv r tea ice,” e D s areas in the United states and peut s the eva r. Simpso ching and he ics f luati n’s r affec or on esear around the world. those profiled ting c cystinos of novel ch hildre is, a thera n’s v rare - here offer a snapshot of that impact. ision disea . se
  • 17. tes, M.D. robert l. es sor of Ophthalmology es Associate Prof e Institute Vanderbilt Ey Nashvill e, Tennessee 81 sidency in 19 Completed re iatric f three ped Dr. Es tes is one o t Eye at Vanderbil ophth almologists sident won four re Insti tute. He has nine years. in the last teach ing awards is able to others, he Becau se he trains excellence mitment to pass on the com niversity of ed at the U that is emphasiz ach many Idaho Mich times the igan, multip M University o lying our re over. “ y re sidency exp f Michigan erience at is the foun- as been my career h datio n on which ly, philo- ly, technical , intellectual .D . ., Ph olog y based says. M.D hically,” he lee, pht halm ould soph ically, and et e a. erin ric o en w kath Practice ediat h childr s a kick s p wit 998 gg’ a It w ” she Kello te Priva , Idaho in 1 ency rking fun. “ Boise ted resid on in hat wo tati ed t ere tim e, s a ro ks w same em i ple Com ssee du ring ee realiz tine tas at the with th ith only as . L ou ing n W It w that Dr g—even r ntertain teractio funny.” provides clin ic ilin b e e ause in tfully ee n’t r sm and h Dr. L ients do p he ne kids ldren bec ten delig Idaho, kee ami pa t he x chi e of s in oung on t to e “ enjoy they ar ologist at her y o serves e’s Pedi- . I d lm h s t - says ipted an ophtha es so t . She al Institu on lead nscr ediatric f servic or care nal Eye as taken Tenne u thre e p h o often f e Natio d h readt h p an . de b avel too ee for t or Grou nizations a wi o tr itt at rga t m tig l o have tive com se Inves essiona u exec Eye Dis s in prea of n atric positio ers hip seo Wei leo, M.D. bismus hthalmology and Stra Head of Pediatric Op apore up The Eye Institute, National Healthcare Gro Singapore Sing in 2005 Completed fellowship mplete a fellowship e to Michigan to co Co ming from Singapor Dr. Leo because er wasn’t easy for at the Kellogg Eye Cent cal and surgical ly ties. But the clini of paperwork and fami more than worthwh ile, experience she gai ned made the effort tric ophthalmology e, she leads a pedia sh e says. In Singapor althcare Group, a for the National He an d strabismus service s 3 million people. “ I enjoy public health ca re entity that serve y ung ones, who reall pecially the very yo helping patients, es to dia gnose and treat or’s clinical acumen depend on the doct holds an academic po sition at . Leo also them,” she says. Dr ity of Singapore. the National Univers
  • 18. Advancing Patient Care Our patients have come to expect exceptional care and access to the newest and best treatments for eye disease. At Kellogg they will find doctors who are leaders in their subspecialties and who also have time to offer a smile and words of encouragement. Erika M. Levin, M.D.
  • 19. GETTING IT STRAIGHTENED OUT Pediatric ophthalmologist improves the vision of Kellogg’s youngest patients No parents want to hear that their child needs surgery. However, when a child has strabismus — a visual disor- der in which the eyes are misaligned and point in differ- ent directions — sometimes surgery is the only treatment that works. Such was the case for Derek and Rebecca Najarian and their 21-month-old daughter, Olivia, from Pinckney, Michigan. “It was the first surgery on our first child and we were scared,” says Mrs. Najarian. “But Dr. Levin treated Dr. Levin heard “proof positve” of the successful surgery. When Olivia and her parents us well every step of the way. She answered every ques- went to Disney World, her improved vision allowed Olivia to see Mickey Mouse tion and explained each step of the process. We grew “jump” out of the 3-D movie and greet the children. more and more comfortable, and, in the end, she really put our minds at ease.” early increases the chances of developing or regaining Erika M. Levin, M.D., a pediatric ophthalmologist stereoscopic vision. If glasses aren’t effective, surgery — at Kellogg, first saw Olivia in May 2003, when she was or a combination of glasses and surgery — is recom- just 16 months old. Olivia’s pediatrician noticed the mended. strabismus at her 15-month well-child visit and referred In September 2003, when Olivia was 21 months “It was the first surgery her to Dr. Levin in Kellogg’s Brighton office. “When I first met Olivia, she was crying,” says old, she underwent success- on our first child and Dr. Levin. “I wasn’t sure if she was nervous or scared, ful strabismus surgery with but we were able to work through the tears. I sang to Dr. Levin repositioning her we were scared. But her, worked quickly and we got the job done.” inner eye muscles. She went Even though Olivia was too young to read an eye home the same day, with- Dr. Levin treated us chart, Dr. Levin was able to examine her using finger out any special bandages well every step of the puppets, mechanical toys and other equipment. Olivia or patches, and returned to had esotropia (inward turning of the eyes), amblyopia (a normal activities within a way, and, in the end, “lazy eye” or poorly-seeing eye) and some far-sightedness. few days. Two months later, Dr. Levin first recommended glasses because they Olivia’s eyes were perfectly she really put our minds can sometimes help straighten the eyes in children with aligned. Her amblyopia hadn’t returned so she didn’t at ease.” esotropia and farsightedness. This was not the case with Olivia. Dr. Levin also patched Olivia’s stronger eye to require further patching. — MS. REBECCA NAJARIAN strengthen the vision in her weaker eye. Once her vision Now, at 6 years old, was equal and her misalignment was stable, Olivia was Olivia sees 20/30 in each ready for surgery. eye without glasses and her eyes remain straight. She The goal in treating strabismus — a condition returns to Kellogg once a year for a follow-up appoint- affecting 4 percent of children in the United States — ment, a visit Dr. Levin eagerly awaits. is to straighten the eyes so they can be used together. “One of the best things about being a pediatric oph- With normal alignment, both eyes aim at the same spot. thalmologist is seeing patients like Olivia grow and de- When one eye is out of alignment, two different images velop over the years,” says Dr. Levin. “It’s so rewarding are sent to the brain. While adults would suffer from to know that I’ve had a positive impact on my patients’ double vision, a child’s brain simply ignores the image lives and on their families’ lives, too. I’m thrilled I can from the misaligned eye. Correcting the misalignment do that for them.” ADVANCING PatIent care 17
  • 20. THE ROAD TO INDEPENDENCE Low Vision Clinic helps patients make the most of their limited vision In 1992, Jeff Crawford came to the U-M Kellogg Eye Center’s Low Vision Clinic with one goal: he wanted to improve his vision so he could earn his driver’s license. He was tired of taking the bus or relying on family and friends to drive him where he needed to go. After working with low vision specialist Donna M. Wicker, O.D., Mr. Crawford achieved his goal and — at age 28 — obtained his first license. He promptly bought a bright yellow Jeep Wrangler. “I figured that if I had any trouble seeing other drivers, at least they would be able to see me,” Mr. Crawford says, laughing. Kellogg’s Low Vision Clinic helps patients with vision loss ranging from mild impairment to legal Jeff Crawford credits Dr. Wicker for helping him live and work on his own terms. blindness. These people typically suffer from macu- lar degeneration, diabetic retinopathy, glaucoma and retinitis pigmentosa. Mr. Crawford is typical of many ture telescopes attached to the top of his eyeglasses — patients with low vision — a term that denotes vision to help him drive. that is 20/70 or less with the best conventional glasses The low vision specialists see about 20 patients prescription. each week, most referred by Kellogg’s clinics and com- Many come to their first appointment with specific munity offices. “Kellogg embraces a multi-disciplinary goals, such as improving their ability to tackle tasks approach to the treatment of low vision,” explains like meal preparation, reading, driving, writing checks Dr. Wicker. “We have a team of ophthalmologists, and paying bills. optometrists and occupational therapists working “When patients come to our clinic, we discuss together to meet each patient’s needs.” specific tasks they would like to accomplish or the ones A low vision patient typically has one to four that give them trouble,” explains Dr. Wicker. “Our job appointments. The last is an optional in-home visit then is to test their vision and optimize their remaining by occupational therapist Karen Murphy, who helps functional vision with the use of optical devices, elec- patients with lighting, safety, contrast and organization. tronic devices and training techniques.” Mr. Crawford, now 44, returns to Kellogg each What patients need most are devices that can mag- year for a check-up with his ophthalmologist and sees nify the objects and material they encounter every day. Dr. Wicker if his vision has changed. Among these are high-power reading glasses, telescopes, “Dr. Wicker and the low vision staff are very pro- and handheld and stand magnifiers. Other devices fessional and friendly and always are concerned about include special telephones and modified closed circuit your well-being,” says Mr. Crawford. “The honesty televisions that enlarge reading material and project it and integrity at Kellogg are phenomenal.” onto a TV monitor. Non-optical devices include large- Thanks to Kellogg, Mr. Crawford can drive to his print items and talking clocks and watches. job of 14 years. He is a machine operator for Edwards It was the telescope that allowed Mr. Crawford to Brothers, a book and journal manufacturing company get that first driver’s license. Because he is legally blind in Ann Arbor. due to congenital cataracts and aniridia (an absent or “Kellogg gave me back my freedom and indepen- partially absent iris), he uses bioptic telescopes — minia- dence,” he states, proudly. 18 UNIVERSITY OF MICHIGAN kellogg eye center
  • 21. RECONSTRUCTING THE ORBIT — see the light at the end of the tunnel,” says Dr. Kahana. Then Taiwo went on to see Gregory Dootz, Kellogg’s and a Young BoY’S FuTurE ocularist who has been creating and fitting prosthetic Oculoplastics service built on teamwork, eyes for Kellogg patients for some 29 years. tough cases One of three surgeons on Kellogg’s Eye Plastic, Orbital and Facial Cosmetic Surgery service, Taiwo Bilesanmi, now a teenager, lost his eye to cancer Dr. Kahana credits his colleagues with having built when he was just one year old and living in Nigeria. His a strong practice that serves family did not have access to a surgeon who could re- as a major referral center for build the child’s orbit, the bones and muscles that form difficult eye plastic surgery. “Orbital reconstruction the eye’s support. The proper supporting structure was Then too, there is the fore- sight of recently retired ser- can be easy to do but essential if Taiwo were, one day, to have a new pros- thetic eye created for him. vice chief, Bartley R. Frueh, hard to do well.” Reconstructive surgery can make a big difference M.D., who came to the in people’s lives, observes Kellogg oculoplastic surgeon Department to start the Eye — ALON KAHANA, M.D., PH.D. Alon Kahana, M.D., Ph.D. At first, Taiwo was too Plastic Service nearly thirty young to care about the loss of his eye, according to years ago. One of his early his father. But as he grew older, he became sensitive to decisions was to hire Gregory Dootz, says Dr. Kahana. comments from his friends about his appearance. By the “Dr. Frueh was an accomplished surgeon who knew time Taiwo came to the Kellogg Eye Center for orbital that to do orbital reconstruction well it was essential reconstruction, the young boy was anxious, but ready to have an expert ocularist on staff and then work for surgery that would allow him to have a new eye. together as a team.” Dr. Kahana was aware the surgery would not be simple. Despite many doctor’s appointments and surgeries, Taiwo, whose family now lives in Detroit, had gone for Taiwo is very positive. His father offered strong encour- some 12 years without an eye or prosthesis, and as a agement, and Taiwo, now 15 years of age, says, “It was result, the orbit had become malformed. Much of the easy except for the surgery. It’s all OK now.” supporting tissue was lost, and the bony structure had grown inward, displacing a silicone implant from an earlier surgery and making it impossible to fit a pros- thetic eye. There was one more obstacle, this one concerned with safety. Before Dr. Kahana would consider surgery, he insisted that Taiwo begin to wear polycarbonate glasses. Like his Kellogg colleagues, Dr. Kahana tells his patients they must protect their “good” eye with shatter-resistant lenses. Dr. Kahana then presented his plan: replace the ear- lier implant with tissue from Taiwo’s thigh to create the supporting structure. There are several techniques a sur- geon can use to reshape the orbit, and many nuances in performing the surgery, says Dr. Kahana. “The ultimate goal is to have good reconstruction that is long lasting and allows for a good prosthetic fit,” he says. “Orbital reconstruction can be easy to do but hard to do well.” After surgery, Dr. Kahana was pleased at last to see a smile on his patient’s face. “I think he finally could Taiwo Bilesanmi at a follow-up visit with Dr. Kahana. ADVANCING PatIent care 19
  • 22. ON THE ROAD AGAIN Big Ten eye doctors go to Vietnam In March, five-year-old Vee, who lives in a small village outside Da Nang, Vietnam, had surgery to correct a tendency for his eyes to turn inward and upward. Vee’s surgeon was pediatric ophthalmologist Monte A. Del Monte, M.D., who had come to Vietnam with ORBIS, an organization that brings a Flying Eye Hospital and Representatives from the Big Ten on the tarmack in Da Nang: Keith Carter, M.D., ophthalmologists to countries where eye care and mod- Derek Del Monte, M.D., Wanda Martinez, M.D., Monte Del Monte, M.D., ern techniques are scarce. and Hua Gao, M.D., Ph.D. There was added commotion, as cameras followed Vee and Dr. Del Monte to film a televised special featur- Dr. Del Monte. “But when we use this technique, we ing ophthalmologists from Big Ten universities teaching see kids opening their eyes and smiling immediately local ophthalmologists and providing surgical treatment after surgery. They have less pain, and they can be in developing countries. outside playing the next day.” Michigan was represented Sure enough, when Dr. Del Monte visited Vee in Training local doctors is by Dr. Del Monte and his home after the surgery, the young boy was doing vital in a country like alumnus Keith C. Carter, just fine, playing with a friend. M.D., who completed his When not performing surgery, Dr. Del Monte Vietnam where just 10 residency at Kellogg and lectured to ophthalmologists who had come from all today is chair of the Univer- over the country. Again stressing its educational mis- ophthalmologists are sity of Iowa’s Department sion, ORBIS asks volunteer physicians to bring several of Ophthalmology. educational lectures when they travel. available per million By the end of the Dr. Del Monte has participated in a number of people. week, Dr. Del Monte had international programs, but this one had special mean- performed 15 surgeries on ing for him. His son, Derek, who completed his medical children and adults with training at Michigan and is now a first-year ophthal- strabismus, a condition in which the eyes are not mology resident at Duke University, accompanied him properly aligned. His young patient Vee had a form on the trip. “The experience sold him on the excitement of strabismus called esotropia with overacting inferior and rewards of international ophthalmology, and in oblique muscles, causing inward turning or crossing and a few years I expect to see him pursue the ORBIS vertical upshooting of his eyes, the most common con- program for third-year residents.” dition Dr. Del Monte saw during his stay in Da Nang. “One of the greatest rewards is that the families At the heart of ORBIS is the goal of training local are so grateful,” adds Dr. Del Monte. “You know how doctors, nurses, and other health workers in state-of- frightened the patients are before surgery, and then you the-art ophthalmic diagnostic and surgical techniques. see big smiles on their faces after they become aware This is vital in a country like Vietnam where just 10 of the results.” Dr. Del Monte was especially touched ophthalmologists are available per million people. by a unique personal gift he received from several of Assisted by a local ophthalmologist during Vee’s his patients’ families: an intricately carved marble tray, surgery, Dr. Del Monte was able to demonstrate a new dragon pitcher and matching cups, each engraved with surgical technique, a stitchless self-closing incision the name of one of his surgical patients. underneath the eyelid in a way that eliminates external Dr. Del Monte will be featured in a televised special stitches. “It is very comfortable for the patient, but to air this fall. Check our web site for details. technically more difficult for the surgeon,” says 20 UNIVERSITY OF MICHIGAN kellogg eye center
  • 23. “You know how frightened the patients are before surgery, and then you see big smiles on their faces after they become aware of the results.” — Monte A. Del Monte, M.D. Dr. Del Monte teaching local ophthalmologists in the O.R. Five-year-old Vee before his surgery. Vee and his parents after his surgery. Hua Imperial Palace, Hua, Vietnam. Sanpan water taxi, Hoi An, Vietnam. Dr. Carter examines a patient’s x-ray. Dr. Del Monte with his local trainees: Dr. Ngoc, Dr. Huang, and Dr. Tan.
  • 24. Celebrating Philanthropy By endowing professorships, providing support for expansion, and making annual gifts to research, individuals and foundations are helping the Kellogg Eye Center reach new levels of excellence. 22 UNIVERSITY OF MICHIGAN kellogg eye center Victor M. Elner, M.D., Ph.D.
  • 25. ENDOWING A LEGACY Ophthalmic pathologist Dr. Victor Elner honored as Ravitz Foundation establishes a professorship that recognizes a little-known specialty When Detroit native Edward Ravitz began a Foundation to help improve the health of his fellow citizens, he decided to support efforts that sought good over glory, says Burton R. Shifman, president of the Ravitz Foundation. Mr. Shifman and his fellow trustees fol- Taking time to celebrate: Ravitz Foundation board members Lawrence F. Handler, M.D., lowed that mission in establishing the Ravitz Bruce D. Gelbaugh, Burton R. Shifman, and Arnold J. Shifman with Kellogg’s Foundation Professorship in Ophthalmology and Paul R. Lichter, M.D., (center left) and Victor M. Elner, M.D., Ph.D. (center right). Visual Sciences at the Kellogg Eye Center this year. Victor M. Elner, M.D., Ph.D., is the first to hold the art camera system that detects eye disease long before professorship. His specialty of ophthalmic pathology the first symptoms occur (see p. 7). is essential to treating and understanding eye disease, Dr. Elner’s clinical specialties include the evaluation but it receives little notice. There are only ten ophthal- and treatment of eyelid and orbital tumors, thyroid eye mic pathologists in the U.S., working to identify the disease and disorders affecting the eyelid and tear ducts. correct source of disease. He has published more than 150 articles on pathologic “In many ways, it’s a dying area of expertise, and entities and advances in eye plastic surgery. I commend the Ravitz Foundation for recognizing its Mr. Ravitz, a businessman who oversaw the build- importance and working to ensure it continues to ing of more than 25,000 single-family homes and benefit patients,” Dr. Elner says. apartments in Michigan and other states, would have As an ophthalmologist and a pathologist, Dr. Elner appreciated the steady, groundbreaking progress Dr. examines eye tissue to draw connections between the Elner has made. From his hardworking immigrant underlying disease process and the most effective ap- parents, Mr. Ravitz learned ethics and responsibility. proaches to diagnosis and treatment. He plays a central He became a decorated combat army officer in World role in training new ophthalmologists. “His appoint- War II, after which he overcame many obstacles in ment as Ravitz Professor will benefit both our Depart- building a company that ultimately grew to 600 indi- ment and the entire field of ophthalmology,” says viduals. Though Mr. Ravitz passed away in 1999, his Paul R. Lichter, chair of the U-M Department of Foundation continues to pursue his vision of supporting Ophthalmology and Visual Sciences. medical research and initiatives that eliminate prejudice Dr. Elner has been on the Kellogg faculty since and further a sense of community and shared humanity. 1988. He received his medical degree, residency train- At U-M, gifts from the Ravitz Foundation have ing, and fellowship training in pathology from the established a professorship in the U-M Department of University of Chicago and completed additional fel- Pediatrics and Communicable Diseases and the Ravitz lowships in pathology and ophthalmic plastic and Foundation Phase 1 / Translational Research Center at reconstructive surgery. His research has shown that the U-M Comprehensive Cancer Center. The Founda- inflammation is often a cause of eye disease or its com- tion has also supported C.S. Mott Children’s Hospital, plications, and he has described the chain of events the U-M Depression Center, the Medical School, the that results in the destruction of cells leading to vision School of Public Health, the Dental School, the Depart- loss. He also collaborated with Kellogg scientist ment of Molecular and Integrative Physiology, and the Howard R. Petty, Ph.D., in developing a state-of-the- Division of Kinesiology. CELEBRATING PhIlanthroPy 23