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Michalek CV (24 August 2016)

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Michalek E

This curriculum vitae provides biographical information about Joel Edmund Michalek, including his contact information, education history, academic appointments, honors and awards, professional development activities, teaching experience, and research expertise and projects. It details his 40 years of experience analyzing clinical and epidemiological studies and 30 years as a pharmaceutical industry consultant.

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CURRICULUM VITAE Joel Edmund Michalek GENERAL INFORMATION PERSONAL DATA: Date of Preparation: 08/22/2016 Address: The University of Texas Health Science Center Department of Epidemiology and Biostatistics, MSC 7933 7703 Floyd Curl Drive, MSN 7933 San Antonio, TX 78229-3900 Phone Number: (210) 567-0886 Fax Number: (210) 567-0921 Email Address: michalekj@uthscsa.edu SELF DESCRIPTION: I have 40 years experience in the analysis and reporting of clinical and epidemiological studies and 30 years experience as a consultant to the pharmaceutical industry, I have published papers in statistical methodology, clinical trials, and epidemiology, and my current interests include methods to analyze survival and count data in cross-over studies. EDUCATION: Year Degree Discipline Institution/Location 1973 PhD Mathematical Statistics Wayne State University, Detroit, MI 1968 MS Mathematics Wayne State University, Detroit, MI 1966 BS Mathematics Wayne State University, Detroit, MI
ACADEMIC APPOINTMENTS: 06/2015 - Present Professor UT Health Science Center at San Antonio, Department of Epidemiology and Biostatistics, San Antonio, TX 06/2006 - 06/2015 Professor and Vice Chairman UT Health Science Center at San Antonio, Department of Epidemiology & Biostatistics, San Antonio, TX 05/2005 - 05/2006 Professor and Co- Director UT Health Science Center at San Antonio, Center for Epidemiology and Biostatistics, San Antonio, TX 03/2005 - 05/2005 Clinical Professor UT Health Science Center at San Antonio, Department of Epidemiology and Biostatistics, San Antonio, TX 09/1993 - Present Adjunct Professor The University of Texas at San Antonio, Department of Management Science and Statistics, San Antonio, TX 09/1973 - 06/1976 Assistant Professor Syracuse University, Department of Mathematics, Syracuse, NY Details: I taught undergraduate and graduate courses in mathematical statistics and probability theory. NON-ACADEMIC APPOINTMENTS: 03/1977 - 05/2005 Mathematical Statistician GS-15 Air Force Research Laboratory, Brooks City- Base, TX Details: Directed Energy Bioeffects Division. Principal Investigator, Air Force Health Study (The Ranch Hand Study): 1994 to 2005.
07/1976 - 02/1977 Mathematical Statistician GS-12 Transportation Systems Center, Cambridge, MA HONORS AND AWARDS: 06/2016 Fellow of the American Statistical Association: For contributions to survival analysis and pharmacokinetics, for novel applications of statistics in assessing adverse health effects of dioxin exposure in Vietnam veterans, for consulting service in private industry, and for service to the nation and the profession. 09/1997 CDC and ATSDR Statistical Science Award: Paper Finalist in recognition of "Pharmacokinetics of TCDD in Veterans of Operation Ranch Hand: 10-Year Follow-up." Journal of Toxicology and Environmental Health. 06/1993 CDC & ATSDR Statistics Award: For statistical excellence demonstrated by the publication of "Effects of Measurement Error on Estimating Biological Half-Life." Journal of Exposure Analysis and Environmental Epidemiology 1993; 2:463-476. PROFESSIONAL DEVELOPMENT: Administrative Date Description C.E. Units/Hours 07/21/1997 - 08/01/1997 Science, Technology & Public Policy - U.S. Office of Personnel Management 0.00 / 0.00 11/06/1992 - 11/11/1992 Science, Technology & Public Policy - U.S. Office of Personnel Management 0.00 / 0.00 05/19/1989 - 05/24/1989 Executive Development Seminar - U.S. Office of Personnel Management 0.00 / 0.00 09/24/1982 - 09/28/1982 Personnel Management for Executives, U.S. Department of Defense 0.00 / 0.00 11/11/1981 - 11/14/1981 Theory Z. Institute for Professional Education 0.00 / 0.00 11/30/1978 - 12/02/1978 Laboratory Management of Research & Development, Air Force Institute of Technology 0.00 / 0.00 Other Date Description C.E. Units/Hours 10/30/2000 - 10/31/2000 Preparing and Delivering Congressional Testimony 0.00 / 0.00 Research
Date Description C.E. Units/Hours 04/25/2007 CITI Certification 0.00 / 0.00 09/25/2004 Human Participant Protections Education for Research Teams, NCI 0.00 / 0.00 04/17/2003 HIPAA Certification Privacy101: Privacy Awareness 0.00 / 0.00 09/13/1985 - 09/15/1985 Future Uses of Medical Databases 0.00 / 0.00 TEACHING COURSE BASED TEACHING: Date Course Name Level Role 08/2007 - 10/2007 STA 6973 Clinical Trials Undergraduate/Graduate Instructor 3 Credits 08/2006 - 09/2007 MEDI6060 Patient Orient Clin Res Method-2 Undergraduate/Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Patient Oriented Clinical Research Methods 2, Masters of Clinical Investigations 09/2004 - 12/2004 PH 1730 Statistical Methods in Epidemiological Research Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Statistical methods in epidemiology
09/2004 - 12/2004 STA 3513 Probability and Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Probability and statistics 05/2004 - 08/2004 STA 1053 Basic statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Elementary statistics 05/2004 - 08/2004 STA 4133 Introductory Data Analysis with Statistical Software Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Data analysis with statistical software 01/2004 - 05/2004 STA 3513 Probability and Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Probability and statistics 01/2004 - 05/2004 STA 5133 Data Analysis with Statistical Software Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Data analysis with statistical software 09/2003 - 12/2003 STA 5133 Data Analysis with Statistical Software Graduate Sole Teacher
Preparation Hrs: 3, Student Contact Hrs: 3 ; Statistical software and applications 05/2003 - 08/2003 STA 3523 Statistical Methods Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 01/2003 - 05/2003 STA 3513 Probability and Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Probability theory and statistics 09/2002 - 12/2002 STA 4953 Special Studies in Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Statistical software and applications 09/2002 - 12/2002 STA 6953 Independent Study Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Statistical software and applications 05/2002 - 08/2002 STA 1053 Basic Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Elementary statistical methods
09/2000 - 12/2000 STA 3513 Probability and Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Probability theory and statistics 09/2000 - 12/2000 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; mathematical statistics 09/1999 - 12/1999 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 01/1999 - 05/1999 STA 5073 Methods of Statistics Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1998 - 12/1998 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 4, Student Contact Hrs: 3 ; Mathematical statistics 01/1998 - 05/1998 STA 5073 Methods of Statistics I Graduate Sole Teacher
Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1997 - 12/1997 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 01/1997 - 05/1997 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1996 - 12/1996 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 01/1996 - 05/1996 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1995 - 12/1995 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics
09/1995 - 12/1995 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1994 - 12/1994 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 01/1994 - 05/1994 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1993 - 12/1993 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics RESEARCH EXPERTISE: NIH Study Sections - Clinical Oncology Study Section, 19 May 2008, Bethesda, MD. Signal processing methods in cardiology - A recent study of admittance technology to measure left ventricular volume employed repeated measures statistical modelling and signal processing methods. The results were published in 2015 in Larson, Erik R, Porterfield, John E., Marmol-Velez, Juan, Panday, Manoj, Sagar, Sandeep, Escobedo, Daniel, Michalek JE, Ouyang, Yongjian, Valvano, Jonathan, Pearce,
John A, Feldman MD. Admittance to Detect Alterations in Left Ventricular Stroke Volume Heart Rhythm 2014 Nov;11(11):2075-2083. PROJECTS: Clinical Research 03/2012- 09/2012 Prevalence of Demyelinating Polyneuropathy, in Patients with Primary Fibromyalgia Russell IJ, Michalek JE. AxelaCare Health Solutions Inc, Lenexa KS 06/2010- Present A Diagnostic Device for Lung Cancer, Cancer Prevention and Cure, Michigan City, Indiana 02/2000- 11/2000 Antipolymer antibodies in the serum of patients with fibromyalgia syndrome, Autoimmune Technologies, LLC 144 Elks Place, Suite 1402, New Orleans, Louisiana 70112 Clinical Trials 01/2013- 06/2013 A Pivotal, Phase III Trial of Detecting Generalized, Tonic-Clonic Seizures with a Seizure Detection and Warning System in Epilepsy Patients. Brain Sentinel, San Antonio, Texas 12/2012- 06/2014 A randomized phase 2 study of G-pen, A randomized, phase 2, double blind, 3-way crossover study with G-PEN (Glucagon for injection) to evaluate safety, tolerability and comparative pharmacokinetics and pharmacodynamics to Lilly Glucagon in healthy volunteers. Xeris Pharmaceuticals, Austin, Texas 06/2012- Present Diabetic foot ulcer healing, A Prospective, Randomized, Double-Blind Multicenter Study Comparing Continuous Diffusion of Oxygen (CDO) Therapy to standard Moist Wound Therapy (MWT) in the Treatment of Diabetic Foot Ulcers. Electrochemical Oxygen Concepts Inc, San Antonio, Texas 06/2010- 06/2013 A randomized controlled study of bracing in the knee, Outcomes of Bracing in the Treatment of Knee Osteoarthritis. Össur hf. Grjothals 3-5 110 Reykjavik Iceland 09/2009- 12/2009 Investigational Device Exemption - G060062/S007, Investigator's Manual/Protocol Study #CP-PYD-001. Ascension Orthopedics Inc, 8700 Cameron Road, Austin TX 78764 06/2008- 06/2010 Probe-based Confocal Endomicroscopy, Sharma P, Meining Am, Coron E, Lightdale C, Wolfsen H, Bansal A, Bajbouj M, Galmiche JP, Abrams J, Lauwers G, Michalek JE, Wallace M. Detection of neoplastic tissue in Barrett‘s esophagus with in vivo probe-based confocal endomicroscopy (DONT BIOPCE). Final results of a prospective international
randomized controlled trial: image guided versus 4 quadrant random biopsies. Mauna Kea Technologies, Paris, France 06/2008- Present Effects of Lyrica, [Pregabaline] on Cerebralspinal Fluid Substance P in Human Subjects with Fibromyalgia Syndrome. Pfizer, New York, New York 01/2007- 12/2007 Phase III laboratory studyof a topical gel formulation, nitroglycerin, MQX-503, in treatment of Raynaud's phenomenon. Clinical study protocol number 03-001. Mediquest Therapeutics, Inc. Seattle, WA 01/2007- 12/2007 Prospective, Randomized, Double-Blind, Multi-Center Trial of Low Dose, Vasopressin versus Placebo in Traumatic Shock Resuscitation 01/2005- 12/2005 A randomized trial of a strategy for increasing high-density lipoprotein, cholesterol levels: effects on progression of coronary heart disease and clinical events. Annals of Internal Medicine 01/2005- 12/2005 Randomized, Double Blind, Placebo-Controlled, Parallel-Group, Multi-Center, Trial Comparing the Effects of Orally Administered Xyrem (sodium oxybate) with Placebo for the Treatment of Fibromyalgia Orphan Medical Inc. Minnetonka MN 01/2004- 12/2004 Determination of the levels of dioxins and dioxin-like compounds, in the Australian population by analysis of pooled human breast milk. Australian Government Department of the Environment and Heritage 01/2002- 12/2002 Alpha-2 adrenergic agonists: evidence and experience examined, Round Table Series 75, The Royal Society of Medicine Press, Ltd 02/2000- 02/2005 Effects of zanaflex® [tizanidine hcl] tablets on, cerebrospinal fluid substance p in human subjects with fibromyalgia syndrome. Elan Pharmaceuticals, Inc. 800 Gateway Boulevard, South San Francisco, CA 94080. 02/2000- 12/2000 Effects on morning stiffness and pain, in the treatment of fibromyalgia syndrome with low dose interferon alpha administered by the oral mucosal route. Veldona USA, Inc., Amarillo, Texas 01/2000- 12/2000 A single-blind, randomized, usual therapy-controlled, double-crossover, study to evaluate the sleep efficacy and safety of the cuddle ewe underquilt in fibromyalgia syntrome. The Cuddle Ewe Company, LLC Maple Grove, MN 05/1999- 07/1999 A double-blind, placebo-controlled study, to evaluate the efficacy and safety of oral glyconutrient supplementation in subjects with fibromyalgia syndrome. 02/1998- 01/1999 A randomized, parallel, placebo-controlled study, of the treatment of Sjogren’s syndrome with low dose interferon alpha administered by the oral mucosal route. Veldona USA, Inc., Amarillo, Texas
01/1998- 12/1998 Treatment of Sjogren‘s syndrome with low dose interferon alpha adminstered, by the oral mucosal route: a randomized, parallel, placebo controlled study. Veldona USA, Inc. Amarillo, TX 02/1993- 02/1994 Treatment of fibromyalgia syndrome with Super Malic, a double-blind placebo controlled crossover pilot study. Optimox Corporation, Torrence, California 11/1991- 04/1992 A Randomized Controlled Clinical Trial to Evaluate the Effect of Intra-Arti, Michalek JE. Pharmacia Orthopedics, Inc. Piscataway, NJ 01/1987- 06/1987 Effects of Ibuprofen and Alprazolam in the Treatment of Fibrositis Syndrome, Russell IJ, Michalek JE, McBroom P, Hester G, Fletcher H, Mauldin M, Miketen S, Tsui-Wu J, Henerson G, Delgado B, Vipraio G, Craighead P. Upjohn, Kalamazoo, MI. Protocol 4105. Collaborative Research 06/2010- 11/2012 Resource Sharing and Cost Recovery Across the CTSA Enterprise, A statistical summary and narrative describing the results of a survey sent to CTSAs. 06/2007- 10/2008 Projecto Bienestar Laredo (PBL), Social Health Research Center, San Antonio, TX 01/2007- 12/2007 Health Canada (CANTOX Environmental). Task 3A-1, Tier 3, Toxicological Risk Assessment Pertaining to Potential Occupational and Related Exposures Associated with Herbicide Spraying Operations at CFB Gagetown 01/2006- 12/2006 Health Canada (CANTOX Environmental) Task 3A-1, Tier 1, Toxicological Risk Assessment Pertaining to Potential Occupational and Related Exposures Associated with Herbicide Spraying Operations at CFB Gagetown-Tier 1-1966-67 U.S. Trials- Manufacturing Impurities (Contaminants). 01/2006- 02/2006 Health Canada (CANTOX Environmental). Task 3A-1, Tier 2, The Toxicological Risk Assessment Pertaining to Potential Occupational and Related Exposures Associated with Herbicide Spraying Operations at Canadian Forces Base (CFB) Gagetown from 1952 to Present 02/2005- 12/2009 Cognitive Assessment, in the fibromyalgia syndrome using a modified trail making test. Russell IJ, Michalek JE. University Clinical Research Center, San Antonio, Texas 02/2005- 02/2005 Hypocretin in Fibromyalgia Syndrome, Russell IJ, Michalek JE. University Clinical Research Center, San Antonio, Texas
01/1993- 12/1993 Biomarkers for Exposure Assesssment, Scientific Workshop on Exposure Assessment, Institute of Medicine, National Academy of Sciences, Washington, DC Departmental Projects 05/1997- 02/2000 Air Force Health Study - Final Report, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. 1997 Follow-up Examination Results. Contract Number: F41624-96-C-1012. 01/1993- 12/1993 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Mortality Update - 1993. Prepared for: The Surgeon General United States Air Force Washington, DC 20314 05/1992- 05/1995 Air Force Health Study - 1992 Follow-up Examination Results, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Contract Number F41624-91-C-1006 01/1992- 01/1994 Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides - Mortality Update 1994. Report Prepared for: The Surgeon General United States Air Force, DC 20332-6188 01/1992- 08/1992 Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Reproductive Outcomes - August 31, 1992. Prepared for: The Surgeon General United States Air Force, Bolling Air Force Base, DC 20332 01/1992- 01/1992 The Air Force Health Study, An epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Reproductive Outcomes. Armstrong Laboratory, Brooks Air Force Base, Texas 1992 02/1991- 02/1991 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Serum Dioxin Analysis of 1987 Follow-up Examination Results. USAF School of Aerospace Medicine, Brooks Air Force Base Texas. (NTIS AD A 237 517 through AD A 237 524), 1991. 01/1991- 12/1991 Air Force Health Study, An Epidemiology Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Mortality Update 1991. Prepared for: The Surgeon General United States Air Force Washington, DC 20314 02/1990- 02/1990 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides, 1987 Follow-up Examination Results. USAF School of Aerospace Medicine.
02/1989- 02/1989 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following exposure to Herbicides: Mortality Update - 1988. USAF School of Aerospace Medicine. 01/1989- 04/1989 Air Force Health Study (Project Ranch Hand II), An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Summary Mortality Update - April 17, 1989. Prepared for: The Surgeon General United States Air Force Bolling AFB, D.C. 20332-6188 02/1987- 02/1987 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. First Follow-up Examination Results. Final Report. USAF School of Aerospace Medicine 01/1986- 12/1986 Air Force Health Study (Project Ranch Hand II), An Epidemiology Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Mortality Update - December 26, 1986. Prepared for: The Surgeon General United States Air Force Washington, D.C 02/1985- 02/1985 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides: Mortality Update - 1985. USAF School of Aerospace Medicine 01/1985- 11/1985 Project Ranch Hand II, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Mortality Update - November 29, 1985. Prepared for: The Surgeon General United States Air Force Washington, D.C. 20314 02/1984- 02/1984 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides: Mortality Update-1984. USAF School of Aerospace Medicine 01/1984- 12/1984 Project Ranch Hand II - Mortality Update - 1984, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Prepared for The Surgeon General United States Air Force Washington, D.C. 20314 Exploratory Grant 01/2012- Present Monoclonal gammopathy, Monoclonal gammopathy of uncertain significance and microRNAs in Ranch Hand veterans. Funded by the Institute of Medicine Other
06/2009- 06/2010 A rebuttal for the plaintiff against the defendant, James Carter PC, Peoria Illinois 09/2006- 09/2007 A rebuttal for the defendant against the plaintiff, Fulbright and Jaworski, San Antonio, Texas Research Projects 06/2013- Present Impact of Ticagrelor, Impact of Ticagrelor and Aspirin versus Clopidogrel and Aspirin in Patients with Claudication and Lower Extremity Arterial Disease (LEAD): Thrombus Burden Assessed by Optical Coherence Tomography Funded by AstraZeneca PUBLICATIONS: ('*' indicates Peer Reviewed) Abstract * 1.McHale MJ, Schlechter AK, Torres FM, Michalek JE, McManus LM, Shireman PK. Gender-specific differences in skeletal muscle regeneration, presented at the Academic Surgical Congress, Association for Academic Surgery, 2010 Feb. p. 218. (J Surg Res; vol. 158, no. 2). * 2.McHale M, Schlechter AK, Torres FM, Michalek JE, McManus LM, Shireman PK. Increased fat accumulation in regenerating skeletal muscle in females 2009 Aug. (Annual Meeting of the San Antonio Vascular Surgery Society). * 3.McHale M, Schlechter AK, Torres FM, Michalek JE, McManus LM, Shireman PK. Gender-dependent fat accumulation in regenerating skeletal muscle. 2009 Jan. (Aust Surgical Society). * 4.Martinez CO, Sun D, Waite LL, Michalek JE, McManus LM, Shireman PK. Differential regulation of skeletal muscle regeneration by CCR2-activating chemokines and in vivo characteristics of myogenic progenitor cells 2008 Oct. (Annual Meeting of the San Antonio Vascular Surgery Society). * 5.Ochoa O, Martinez C, Torres FM, Ruiz-Willhite L, Michalek JE, McManus LM, Shireman PK. Differential regulation of skeletal muscle regeneration and angiogenesis by CCR2-activating chemokines, presented at the Academic Surgical Congress, Association for Academic Surgery, 2008 Feb. p. 218-219. (J Surg Res; vol. 144, no. 2).
* 6.Sun D, Wetzel MD, Waite LL, Michalek JE, Shireman PK. Environmental factors determine in vivo myogenic progenitor cell function, presented at the Academic Surgical Congress, Society of University Surgeons, 2008 Feb. p. 217-218. (J Surg Res; vol. 144, no. 2). * 7.Sanchez J, Angel LF, Levine DJ, Johnson SB, Michalek JE, Zarzabal LA, Sako E, Pelaez A, Mehta A, Calhoon J, Levine SM, Lyu D. Using Post-Lung Transplant FEV1 To Predict Survival in COPD Patients Undergoing Single Lung Transplantation (SLT) 2007 Oct. p. 596. (CHEST; vol. 132, no. 4). * 8.Shireman PK, Sun D, Ochoa O, Bonilla JR, Waite LL, Michalek JE, McManus LM. Increased myogenic progenitor cell accumulation in CCR2 -/- mice despite bone marrow-dependent impairments in muscle regeneration and macrophage recruitment 2007 Jul. (Skeletal Muscle Satellite & Stem Cells, FASEB Summer Meeting). * 9.Sanchez, JF, Angel LF, Levine DJ, Johnson SB, Calhoon JH, Sako EY, Carpenter AJ, Michalek JE, Levine SM. A Mathematical Model to Predict the Best FEV1 Post Single Lung Transplantation 2007 May. p. A765. (2007 Proceedings of the American Thoracic Society). * 10.Ochoa O, Solomon D, Michalek JE, McManus LM, Shireman PK. Similar capillary density despite decreased vascular endothelial growth factor (VEGF) levels and impaired skeletal muscle regeneration in CC chemokine receptor 2 (CCR2) -/- mice, presented at the Academic Surgical Congress, Society of University Surgeons 2007 Feb. p. 211-212. (J Surg Res; vol. 137, no. 2). * 11.Sanchez J, Angel L, Levine D, Johnson S, Calhoon JH, Sako E, Carpenter A, Michalek JE, Levine SM. A mathematical model to predict the best fev1 post single lung transplantation 2007 Jan. p. A765. (Am J Respir Critical Care Medicine; vol. 175). * 12.Shireman PK, Sun D, Ochoa O, Bonilla JR, Waite LL, Michalek JE, McManus LM. Bone marrow-derived cell regulation of skeletal muscle regeneration. Bandera, TX: 2007. (Proceedings of the International Conference on Age-related Muscle Atrophy: Causes and Mechanisms). * 13.Levine DJ, Angel LF, Coalson JJ, Cline, A, Calhoon JH, Michalek JE, Johnson SB, Sako EY, Carpenter AJ, Levine SM. Histologic Evidence of Pulmonary Arterial Hypertension in Explants of Lung Transplant Recipients With Normal Pre-operative Cardiac Catheterization and Echocardiography 2006. (American Journal of Respiratory and Critical Care Medicine). * 14.Michalek J. Insulin sensitivity following Agent Orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. 2004 Nov. * 15.Pavuk M, Michalek JE and Schecter A. Incidence of prostate cancer in Vietnam US Air Force veterans. 2004 Mar.
* 16.Pavuk M, Michalek JE, Jackson Jr W, and Ketchum NS. The metabolic syndrome and cardiovascular mortality in US Air Force veterans of the Vietnam War. 2004. p. 3651- 3656. (Organohalogen Compounds; vol. 66). * 17.Ketchum NS and Michalek JE. Mortality of Air Force veterans exposed to herbicides during the Vietnam War. 2004. p. 3645-3660. (Organohalogen Compounds; vol. 66). * 18.Pavuk M, Michalek J, Ketchum N and Akhtar F. Cancer in US Air Force veterans not involved with spraying herbicides during the Vietnam War. 2004. p. 3639-3644. (Organohalogen Compounds; vol. 66). * 19.Kern P, Said S, Jackson Jr W, Michalek J.. Insulin sensitivity and serum TCDD in Air Force veterans occupationally exposed to herbicides during the Vietnam War. 2004. p. 3166-3173. (Organohalogen Compounds; vol. 66). * 20.Emond C, Michalek JE, Birnbaum LS and DeVito MJ. Use of a PBPK model with dose- dependent elimination rates predicts higher peak dioxin exposures than previously estimated. 2004. p. 2655-2659. (Organohalogen Compounds; vol. 66). * 21.Michalek J. Cancer findings from Air Force veterans who sprayed Agent Orange: Correlation of blood TCDD with cancers. 2003 Nov. * 22.Pavuk M, Schecter A and Michalek J. Correlation of TCDD blood levels with adverse prostate outcome in Air Force veterans who sprayed Agent Orange. 2003 Nov. * 23.Pavuk M, Michalek JE and Schecter A. TCDD and prostate cancer in US Air Force veterans of the Vietnam War. 2003 Sep. * 24.Pavuk M, Schecter A and Michalek JE. Association between diseases of the prostate and TCDD in US Air Force veterans of the Vietnam War. 2003. p. 239-241. (Organohalogen Compounds; vol. 64). * 25.Akhtar F, Garabrant D and Michalek J. Cancer in US Air Force veterans of the Vietnam War. 2003. p. 243-246. (Organohalogen Compounds; vol. 64). * 26.Kern P, Said S, Jackson Jr W and Michalek J. Insulin sensitivity and 2,3,7,8- tetrachlorodibenzo-p-dioxin in US Air Force veterans of the Vietnam War. 2003. p. 182-185. (Organohalogen Compounds; vol. 65). * 27.Dwyer JH, Jackson Jr WH and Michalek JE. Hypertension and 2,3,7,8- tetrachlorodibenzo-p-dioxin. 2002 Nov. * 28.Pavuk M, Schecter A, Akhtar F, Michalek J. Thyroid changes in relation to TCDD in Ranch Hand veterans of the US Air Force. 2002 Nov.
* 29.Russell IJ, Michalek JE, Xiao YM, Haynes W and Lawrence RA. Like morning stiffness in rheumatoid arthritis, morning stiffness in fibromyalgia is related to serum hyaluronic acid. 2002 Oct. (American College of Rhematology). * 30.Russell IJ, Michalek JE, Xiao YM, Haynes W, Vertiz R and Lawrence RA. Therapy with a central alpha-2-adrenergic agonist [tizanidine] decreases cerebrospinal fluid substance P, and may reduce serum hyaluronic acid as it improves the clinical symptoms of the fibromyalgia syndrome. 2002 Oct. (American College of Rheumatology). * 31.Wilson RB, Xiao YM, Michalek JE and Russell IJ. Correlation of Anti-Polymer Antibodies with Clinical Measures in Fibromyalgia Syndrome. 2002 Oct. (American College of Rheumatology). * 32.Dwyer JH, Jackson Jr W, Michalek JE. Hypertension and serum 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and hypertension in the Air Force veterans of the Vietnam War. 2002. p. 331-334. (Organohalogen Compounds; vol. 59). * 33.Pavuk M, Schecter AJ, Akhtar FZ, Michalek JE. Effects of TCDD on thyroid metabolism in US Air Force herbicide sprayers. 2002. p. 347-350. (Organohalogen Compounds; vol. 59). * 34.Michalek J, Pirkle JL, Needham LL, Patterson Jr DG and Caudill SP. Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of Operation Ranch Hand. 2001 Nov. * 35.Russell IJ, Michalek JE, Haynes WL and Vertiz R. A single blind, randomized, three period, three treatments, crossover study to evaluate the sleep efficacy of the cuddle ewe under quilt™ for treatment of fibromyalgia. 2001 Feb. (J Musculoske Pain; vol. 9, no. Suppl). * 36.Michalek JE, Akhtar FZ, Ketchum NS and Jackson Jr WG. The Air Force Health Study: A summary of results. 2001. p. 396-399. (Organohalogen Compounds; vol. 54). * 37.Barrett DH, Morris RD, Akhtar FZ and Michalek JE. Serum TCDD and cognitive functioning in Veterans of Operation Ranch Hand. 2001. p. 145-148. (Organohalogen Compounds; vol. 53). * 38.Michalek JE, Ketchum NS and Longnecker MP. Serum TCDD and hepatic abnormalities in Veterans of Operation Ranch Hand. 2001. p. 159-162. (Organohalogen Compounds; vol. 53). * 39.Michalek JE, Akhtar FZ, Longnecker MP, Burton JE. Serum TCDD and hematological examination results in Veterans of Operation Ranch Hand. 2001. p. 172-175. (Organohalogen Compounds; vol. 53).
* 40.Barrett DH, Morris RD, Jackson Jr WG and Michalek JE. Serum TCDD and psychological functioning in Veterans of Operation Ranch Hand. 2001. p. 176-179. (Organohalogen Compounds; vol. 53). * 41.Michalek JE, Pirkle JL, Needham LL, Patterson DG, Caudill SP, Tripathi RC, Mocarelli P. Pharmacokinetics of 2,3,7,8-Tetrachlorodibenzo-P-dioxin in Seveso adults and Veterans of Operation Ranch Hand. 2001. p. 340-344. (Organohalogen Compounds; vol. 52). * 42.Xiao Y-M, Russell IJ, Michalek JE and Wilson RB. Anti-polymer antibodies in the serum of patients with fibromyalgia syndrome. 2001. (J Musculoske Pain; vol. 6, no. S5). * 43.Michalek J, Longnecker MP and Akhtar FZ. Dioxin and hematological function in veterans of Operation Ranch Hand. 2000 Nov. * 44.Michalek JE and Ketchum N. Serum dioxin and cancer in veterans of Operation Ranch Hand. 2000. p. 99-102. (Organohalogen Compounds; vol. 48). * 45.Akhtar FZ and Michalek JE. Serum dioxin and peripheral neuropathy in veterans of Operation Ranch Hand. 2000. p. 179-182. (Organohalogen Compounds; vol. 48). * 46.Jackson Jr WG and Michalek JE. Herbicide exposure and heart disease in veterans of operation Ranch Hand. 2000. p. 183-186. (Organohalogen Compounds; vol. 48). * 47.Ketchum N and Michalek JE. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. 2000. p. 256-259. (Organohalogen Compounds; vol. 48). * 48.Ketchum NS, Michalek JE and Burton JE. Serum dioxin and cancer in veterans of operation Ranch Hand. 1999. p. 363-366. (Organohalogen Compounds; vol. 44). * 49.Longnecker MP and Michalek JE. Serum dioxin level in relation to diabetes mellitus and glucose intolerance among Air Force veterans with background levels of exposure. 1999. p. 401-404. (Organohalogen Compounds; vol. 44). * 50.Michalek JE and Boyle CA. Paternal serum dioxin, preterm birth, intrauterine growth retardation and infant death. 1998. p. 223-226. (Organohalogen Compounds; vol. 38). * 51.Michalek JE, Ketchum NS and Akhtar FZ. Post-service mortality of Air Force veterans occupationally exposed to herbicides in Vietnam: 15 Year Follow-up. 1998. p. 235-238. * 52.Michalek JE and Ketchum NS. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. 1997. p. 479-484. (Organohalogen Compounds; vol. 34).
* 53.Russell IJ, Michalek JE and Vipraio GA. Serotonin (5HT) in serum and platelets (PLT) from fibromyalgia patients (FM) and normal controls (NC). 1995 Jul. (Third World Congress on Myofascial Pain and Fibromyalgia (abst)). * 54.Russell IJ, Vodjani A, Michalek JE, Vipraio GA, Lopez Y and MacKillip F. Circulating antibodies to serotonin (ASA) in fibromyalgia syndrome (FS) rheumatoid arthritis (RA) osteoarthrosis (OA) and healthy normal controls (NC). 1995 Jul. (Third World Congress on Myofascial Pain and Fibromyalgia). * 55.Michalek J, Russell I, Vipraio GA. Serotonin (5HT) in serum and platelets (PLT) from fibromyalgia patients (FM) and normal controls (NC). 1995. p. 144-144. (J Musculoske Pain; vol. 3, no. S1). * 56.Russell IJ, Orr MD, Michalek JE, Nyberg F, Eriksson U. Substance P (SP), SP endopeptidase activity (SPE), and SP N-terminal peptide (SP1-7) in fibromyalgia syndrome cerebrospinal fluid (CSF). 1995. p. 5-5. (J Musculoske Pain; vol. 3, no. S1). * 57.Russell IJ, Orr MD, Vipraio GA, Alboukrek D, Michalek JE and Lopez YM. Cerebrospinal fluid (CSF) substance P (SP) is elevated in fibromyalgia syndrome (FS). 1993. (Arthritis and Rheumatism; vol. 36, no. S223). * 58.Russell IJ, Vipraio GA, Michalek JE and Lopez YG. Insulin-like growth factor (IGF1) in fibromyalgia (FS), rheumatoid arthritis (RA), osteoarthritis (OA) and healthy normal controls (NC): Roles of diagnosis, age, sex and ethnic origin. 1992. (Arthritis Rheum; vol. 35, no. S160). * 59.Russell IJ, Michalek JE, Vipraio GA, Lawrence VA, Lessard JA and Briggs BT. Automated reading of joint space on osteoarthritis X-rays: Correlation with clinical manifestations. 1992. (Arthritis Rheum; vol. 35, no. S133). * 60.Russell IJ, Michalek JE, Lawrence VA, Lessard JA, Briggs BT and May GS. A randomized, placebo (PL) and no-intervention (NI) controlled, trial of intra-articular (IA) 1% sodium hyaluronate (HA) in the treatment of knee osteoarthritis. 1992. (Arthritis Rheum; vol. 35, no. S132). * 61.Russell IJ, Russell SJ, Cuevas RE and Michalek JE. Early life traumas and confiding in fibromyalgia syndrome (FS). 1992. (Scand J Rheumatol; vol. 94, no. S14). * 62.Russell IJ, Michalek JE, Vipraio GA, Fletcher EM and Wall K. Serum amino acids in fibrositis/fibromyalgia syndrome. 1989. (Arthritis Rheum; vol. 32, no. S70). * 63.Russell IJ, Fletcher EM, Tsui J and Michalek JE. Comparisons of rheumatoid arthritis and fibrositis/fibromyalgia syndrome using functional and psychological outcome measures. 1989. (Arthritis Rheum; vol. 32, no. S70).
* 64.Russell IJ, Fletcher EM, Michalek JE, McBroom PC and Hester GG. Efficacy and safety of ibuprofen and alprazolam in the treatment of primary fibrositis/fibromyalgia syndrome. 1989. (Arthritis Rheum; vol. 32, no. S69). * 65.Russell IJ, Bowden CL, Michalek JE, Fletcher EM and Vipraio GA. A metabolic basis for fibrositis syndrome (FS): The serotonin deficiency hypothesis. 1988 May. (ARA Meeting). * 66.Russell IJ, Vipraio GA, Michalek J and Fletcher E. Abnormal T cell subpopulations in fibrositis syndrome. 1988. (Arthritis Rheum; vol. S99). * 67.Russell IJ, Vipraio GA, Tovar Z, Michalek J, and Fletcher E. Abnormal natural killer cell activity in fibrositis syndrome is responsive in vitro to IL-2. 1988. (Arthritis Rheum; vol. S24). * 68.Russell IJ, Bowden CL, Michalek J, Fletcher E and Hester GA. Imipramine receptor density on platelets of patients with fibrositis syndrome: Correlation with disease severity and response to therapy. 1987 Apr. p. 563. (Arthritis Rheum; vol. 30, no. S4). Book Chapter 1.Michalek JE, Cornell JE, Pollock BH. Understanding the Elements that Comprise Evidence-Based Medicine In: Elective General Surgery: An Evidence-Based Approach. Shelton, CT: PMPH-USA Ltd.; 2011. 2.Xiao YM, Michalek JE and Russell IJ. Effects of tizanidine on cerebrospinal fluid substance P in patients with fibromyalgia In: Round Table Series-75. Worcester, UK: The Royal Society of Medicine Press, The Trinity Press; 2001. p. 23 - 28. Journal Article * 1.Simpson, CB, Lee CT, Hatcher JL, Michalek JE. Botulinum toxin treatment of false vocal folds in adductor spasmodic dysphonia: functional outcomes Laryngoscope 2016;126:118-121. * 2.Ha CS, Michalek JE, Elledge R, Kelley KR, Ganapathy S, Su H, Jenkins CA, Agiris A, Swords R, Eng TY, Karnad A, Crownover RL, Swanson GP, Goros M, Pollock BH, Yuan Z. p53-based strategy to reduce hematological toxicity of chemotherapy: A proof of principle study Molecular Oncology 2015 Oct;XXX(YYY)
* 3.Landgren, O, Shim, Y, Michalek JE, Costello, R, Burton, D, Ketchum, N, Calvo, K, Caporaso, N, Raveche, E, Middleton, D, Marti, G, Vogt, R. Agent Orange Exposure and Monoclonal Gammopathy of Undetermined Significance. An Operation Ranch Hand Veteran Cohort Study JAMA Oncology 2015 Sep:E1-E8. * 4.Strandberg G, Larsson A, Lipcsey M, Michalek JE, Eriksson M. Intraosseous and intravenous administration of antibiotics yields comparable plasma concentrations during experimental septic shock Acta Anaesthesiol Scan 2015 Jan * 5.Bartanusz Viktor, Jezova Daniela, Sordo Salvador, Gildea Marianne, Michalek JE, Stewart Ronald M, Corneille Michael G.. Diurnal Salivary Cortisol Levels in Acute Trauma Patients at the Surgical-Neurosurgical Intensive Care Unit J Clin Neurosci 2014 Dec;21(12):2150-2154. * 6.Larson, Erik R, Porterfield, John E., Marmol-Velez, Juan, Panday, Manoj, Sagar, Sandeep, Escobedo, Daniel, Michalek JE, Ouyang, Yongjian, Valvano, Jonathan, Pearce, John A, Feldman MD. Admittance to Detect Alterations in Left Ventricular Stroke Volume Heart Rhythm 2014 Nov;11(11):2075-2083. * 7.Shi Q, Hodara V, Meng Q, Voruganti VS, Rice K, Michalek JE, Carmuzzie AG, VandeBerg JL. Early endothelial damage detected by circulating particles in baboons fed a diet high in simple carbohydrates in conjunction with saturated or unsaturated fat Am J Cardiovasc Dis 2014 Oct;4(3):123-132. * 8.Abraham J, Nunez-Alvarez Y, Hettmer S, Carrio E, Chen HI, Nishijo K, Huang ET, Prapjapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansool A, Chen Y, Suelves M, Rubin BP, Keller C. Lineage of origin in rhabdomyscarcoma informs pharmacological response Genes Dev 2014 Jul;25(14):1578-1591. * 9.Kilpadi KL, ElDabaje R, Schmitz JE, Ehler B, Thames TA, Joshi AP, Simmons JW, Michalek JE, Fajardo RJ. Type 2 diabetes is associated with vertebral fractures in a sample of clinic- and hospital-based latinos. J Immigr Minor Health 2014 Jun;16(3):440-449. * 10.Mahalingam D, Malik L, Beeram M, Rodon J, Sankhala K, Mita AC, Benjamin D, Ketchum N, Michalek JE, Tolcher A, Wright J, Sarantopoulos J. Phase II Study Evaluating the Effcacy, Safety, and Pharmacodynamic Correlative Study of Dual Antiangiogenic Inhibition Using Bevaciumab in Combination with Sorafenib in Patients with Advanced Malignant Melanoma Cancer Chemother Pharmacol 2014 May * 11.Cohn SM, DeRosa M, Kumar A, Harrison C, Dent DL, Sivam S, McCarthy MJ, Warner SC, Williams S, Michalek JE, Spinella P. Impact of the Age of Transfused Red Blood Cells in the Trauma Population: A Feasibility Study Injury 2014 Mar;45(3):605-611.
* 12.Kikuchi, Hettmer S, Aslam MI, Michalek JE, Laub W, Wilky BA, Loeb DM, Rubin BP, Wagers AJ, Keller C. Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma PLos Genet 2014 Jan;10(1) * 13.Rowe J, Patel S, Mazo-Canola M, Parra A, Goros M, Michalek JE, Kelly KR, Weitman SD, Karnad AB. An Evaluation of Elderly Patients (> 70 years old) Enrolled in Phase I clinical trials at University of Texas Health Science Center at San Antonio Cancer Therapy Research Center from 2009-2011 J Geriatr Oncol 2014 Jan;5(1):65-70. * 14.Hummers LK, Dugowson CE, Dechow FJ, Wise RA, Gregory J, Michalek JE, Yenokyan G, McGready J, Wigley FM. A Multi-Centre, Blinded, Randomsied, Placebo- Controlled, Laboratory-Based Study of MQX-503, a Novel Topical Gel Formulation of Nitroglycerine in Patients with Raynaud Phenomenon Ann Rheum Dis 2013 Dec;72(12):1962-1967. * 15.Kikuchi k, Taniguchi E, Chen HI, Svalina MN, Abraham J, Huang ET, Nishijo K, Davis S, Louden C, Zarzabal LA, Recht O, Bajwa A, Berlow N, Suelves M, Perkins SL, Meltzer PS, Mansoor A, Michalek JE, Chen Y, Rubin BP, Keller C. RB1 Loss Modifies but does not Initiate Alveolar Rhabdomyosarcoma Skelet Muscles 2013 Nov;3(1) * 16.Aslam MI, Hettmer S, Abraham J, Latocha D, Soundararajan A, Huang ET, Goros MW, Michalek JE, Wang S, Mansoor A, Druker BJ, Wagers AJ, Tyner JW, Keller C. Dynamic and Nuclear Expression of PDGFRa and IGF-1R in Alveolar Rhabdomyosarcoma Mol Cancer Res. 2013 Nov;11(11):1303-1313. * 17.Cohn SM, DeRosa M, McCarthy J, Song J, White C, Louden C, Ehler B, Michalek JE, Landry DW. Characterizing Vasopressin and other Vasoactive Mediators Released During Resuscitation of Truama Patients J Trauma Acute Care Surg 2013 Oct;75(4):620-628. * 18.Xiao Y, Haynes W, Russell IJ, Michalek JE. Elevated serum high-sensitivity c-reactive protein levels in fibromyalgia syndrome patients correlate with body mass index, interleukin-6, interleukin-8, erythrocyte sedimentation rate Rheumatol Int 2013 May;33(5):1259-1264. * 19.Schwartz JA, Olarte KT, Michalek JL, Jandu GS, Michel SL, Bruno VM, Michalek JE. Regulation of copper toxicity by Candida albicans GPA2. Eukaryot Cell 2013 Apr * 20.Thompson PM, Bernardo CG, Cruz D, Ketchum N, Michalek JE. Transl Psychiatry Transl Psychiatry 2013 Jan;3:214-214. * 21.Kikuchi K, Soundararajan A, Zarzabal LA, Weems CR, Nelon LD, Hampton ST, Michalek JE, Rubin BP, Fields AP, Keller C. Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma Oncogene 2013 Jan;32(3):286-295.
* 22.Garcia-Dominic O, Trevino RP, Echon RM, Mobley C, Block T, Bizzari A, Michalek JE. Improving Quality of Food Frequency Questionnaire Response in Low-Income Mexican American Children Health Promot Pract 2012 Nov;13(6):763-771. * 23.Soundararajan A, Abraham J, Nelon LD, Prajapati SI, Zarzabal LA, Michalek JE, McHardy SF, Hawkins DS, Malempati S, Keller C. 18F-FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically engineered rhabdomyosarcoma models Pediatr Blood Cancer 2012 Sep;59(3):485-492. * 24.Husain SA, Maldonado E, Rasch D, Michalek JE, Taylor R, Curzon C, Neish S, Calhoon JH. Total anomalous pulmonary venous connection: factors associated with mortality and recurrent pulmonary venous obstruction Ann Thorac Surg 2012 Sep;94(3):825-831. * 25.Cornejo A, Sahar DE, Stephenson SM, Chang S, Nguyen S, Guda T, Wenke JC, Vasquez, A, Michalek JE, Sharma R, Krishnegowda NK, Wang HT. Effect of Adipose Tissue-Derived Osteogenic and Endothelial Cells on Bone Allograft Osteogenesis and Vascularization in Critical-Sized Calvarial Defects. Tissue Eng Part A 2012 May;18(15- 16):1-10. * 26.McHale MJ, Sarwar ZU, Cardenas DP, Porter L, Salinas AS, Michalek JE, McManus LM, Shireman PK. Increased fat deposition in injured skeletal muscle is regulated by sex-specific hormones. PMCID: PMC3289262 Am J Physiol Regul Integr Comp Physiol 2012 Jan;302:R331-339. * 27.Abraham J, Chua YX, Glover JM, Tyner JW, Loriaux MM, Kilcoyne A, Giles FJ, Nelon LD, Carew JS, Ouyang Y, Michalek JE, Pal R, Druker BJ, Rubin BP, Keller C. An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma Biochem Biophys Res Commun 2012;426:363-368. * 28.Izbicka E, Streeper RT, Michalek JE, Louden CL, Diaz A, Campos DR. Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women. Cancer Genomics Proteomics 2012 Jan;9(1):27-35. * 29.Salhanick M, Higgins RA, Olson JD, Michalek JE, Harrison CR, Corneille MG, Stewart RM, Harrison C,Dent DL,. Autotransfusion of Hemothorax Blood In Trauma Patients: Is It the Same as Fresh Whole Blood? Am J Surg 2011 Dec;202(6):817-822. * 30.Meining A, Chen YK, Pleskow D, Stevens P, Shah RJ, Chuttani R, Michalek J, Slivka A. Direct visualization of indeterminate pancreaticobiliary strictures with probe-based confocal laser endomicroscopy: a multicenter experience Gastrointest Endosc 2011 Nov;74(5):961-968. * 31.Cornejo A, Rodriguez T, Steigelman M, Stephenson S, Sahar D, Cohn SM, Michalek JE, Wang HT. The use of visible light spectroscopy to measure tissue oxygenation in free flap reconstruction. Journal of Reconstructive Microsurgery 2011 Sep;27(7):397- 402.
* 32.Sharma P, Meining AR, Coron E, Lightdale CJ, Wolfsen HC, Bansal A, Bajbouj M, Galmiche JP, Abrams JA, Rastogi A, Gupta N, Michalek JE, Lauwers GY, Wallace MB. Real-time increased detection of neoplastic tissue in Barrett‘s esophagus with probe-based confocal laser endomicroscopy: final results of an international multicenter, prospective, randomized, controlled trial Gastrointest Endosc 2011 Sep;74(3):465-472. * 33.Sambasivan, CH, Kunio, NR, Nair, PV, Zink, KA, Michalek JE, Holcomb, JB, Schreiber, MA, Trauma Outcomes Group, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudsen P, DeMoya MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Bielman G, Peitzman AB, Zenalt MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzales EA, Stewart RM, Cohn SM, Bulgar EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Propper GJ, Marin B. High Ratios of Plasma and Platelets to Packed Red Blood Cells Do Not Affect Mortality in Nonmassively Transfused Patients Journal of Trauma 2011 Aug;71(2):S329-S336. * 34.Li X, Villard JW, Ouyang Y, Michalek JE, Jabara R, Sims D, Kemp N, Glynn T, Banas C, Bailey SR, Feldman MD. Safety and efficacy of frequency domain optical coherence tomography in pigs. EuroIntervention 2011 Aug;7(4):497-504. * 35.Holcomb JB, Zarzabal LA, Michalek JE, ozar RA, Spinella PC, Perkins JG, Matijevic N, Dong JF, Pati S, Wade CE, Trauma Outcomes Group, Holcomb JB, Wade CE, Cotton BA, Kozar RA, Brasel KJ, Vercruysse GA, MacLeod JB, Dutton RP, Hess, JR, Duchesne JC, McSwain NE, Muskat PC, Johannigamn JA, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, DeMoya MA, Schreiber MA, Tieu BH, Brundage SL, Napolitano LM, Brunsvold ME, Sihler KC, Beilman GJ, Peitzman, AB, Zenati, MS, Sperry JL, Alarcon LH, Croce MA, Minei JP, Steward RM, Cohn SM, Michalek JE, Bulger EM, Nunez TC, Ivatury RR, Meredith JW, Miller PR, Propper GJ, Marin B. Increased Platelet:RBC ratios are associated withimproved survival after massive transfusion J Trauma 2011 Aug;71(2s3):s318-s328. * 36.Spoerke N, Michalek JE, Schreiner JM, Trauma Outcomes Group, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, De Moya MA, Tieu B, Brudage S, Napolitano LM, Brunsvold MA, Sihler KC, Peitzman AB, Zenait MX, Sperry J, Alarcon L, Croce MA, Minei JP, Stewart RM, Cohn SM, Buger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Propper GJ. Crystalloid resuscitation improves survival in trauma patient receiving low ratios of fresh frozen plasma to packed red blood cells J Trauma 2011 Aug;71(2S3):S380-S383. * 37.Corneille MG, Nicholsen, S, Richa, J, Son, C, Michalek JE, Wolf SE, Stewart RM. Liver Dysfunction by Model for End-Stage Liver Disease Score Improves Mortality Prediction in Injured With Cirrhosis The Journal of Trauma 2011 Jul;71(1)
* 38.McNeil JD, Brandon Propper, Joshua Walker, Lauren Holguin, Lauren Evans, Kihak Lee, Fox PT, Michalek JE, Baisden CE. A bovine hemoglobin-based oxygen carrier as pump prime for cardiopulmonary bypass: reduced systemic lactic acidosis and improved cerebral oxygen metabolism during low-flow in a porcine model Journal of Thoracic and Cardiovascular Surgery 2011 Jun;142(2):411-417. * 39.Prajapati SI, Kilcoyne A, Samano AK, Green DP, McCarthy SC, Blackman BA, Brady MM, Zarzabal LA, Tatiparthy AK, Sledz TJ, Duong T, Ohshima-Hosoyama S, Giles FJ, Michalek JE, Rubin BP, Keller C. MicroCT-based virtual histology evaluation of preclinical medulloblastoma Mol Imaging Biol 2011 Jun;13(3):493-499. * 40.Streeper RT, Diaz A, Campos D, Michalek JE, Louden C, Furmaga W, Izbicka E. Syntra-5 Downregulates Inflammatory In Obese Type 2 Diabetes Murine Model In Vivo. Curr Top Nutraceutical Res 2011 May;9(1/2):1-12. * 41.Hosoyama T, Aslam MI, Abraham J, Prajapati SI, Nishijo K, Michalek JE, Zarzabal LA, Nelon LD, Guttridge DC, Rubin BP, Keller C. IL-4R drives dedifferentiation, mitogenesis in rhabdomyosarcoma Clin Cancer 2011 May;17(9):2757-2766. * 42.Swanson GP, Du F, Michalek JE, Hermans M. Long-term follow-up and risk of cancer death after radiation for post-prostatectomy rishing prostate-specific antigen Int J Radiat Oncol Biol Phys 2011 May;80(1):62-68. * 43.Abraham J, Nelon LD, Kubicek CB, Kilcoyne A, Hampton ST, Zarzabal LA, Giles FJ, Michalek JE, Rubin BP, Keller C. Preclinical testing of erlotinib in a transgenic alveolar rhabdomyosarcoma mouse model. Sarcoma 2011 Apr;2011:130484-130484. * 44.Michalek JE, Preuss HG, Croft HA, Keith PL, Keith SC, Dapilmoto M, Perricone NV, Leckie RB, Kaats GR. Changes in total body bone mineral density following a common bone health plan with two versions of a unique bone health supplement: a comparative effectiveness research study Nutr J 2011 Apr;10(32) * 45.Bini JK, Cohn SM, Acosta SM, McFarland MJ, Muir MT, Michalek JE. Mortality, Mauling, and Maiming by Vicious Dogs Ann Surg 2011 Apr;253(4):791-797. * 46.Mueller DL, Hatab M, Al-Senan R, Cohn SM, Corneille MG, Dent DL, Michalek JE, Myers JG, Wolf SE, Stewart RM. Pediatric Radiation Exposure During the Initial Evaluation for Blunt Trauma J Trauma 2011 Mar;70(3):724-731. * 47.Woodward CS, Son MG, Calhoon JH, Michalek JE, Husain SA. Sternal Wound Infections in Pediatric Congential Cardiac Surgery: A Survey of Incidence and Preventative Practice Ann Thorac Surg 2011 Mar;91(3):799-804. * 48.Cohn SM, McCarthy J, Stewart RM, Jonas RB, Dent DL, Michalek JE, UTHSCSA Clinical Trials Group (Mueller D, member of the investigative group). Impact of Low- dose Vasopressin on Trauma Outcome: Prospective Randomized Study. World J Surg 2011 Feb;35(2):430-439.
* 49.Rubin BP, Nishijo K, Chen HI, Yi X, Schuetze DP, Pal R, Prajapati SI, Abraham J, Arenkiel BR, Chen QR, Davis S, McCleish AT, Capecchi MR, Michalek JE, Zarzabal, LA, Khan J, Yu Z, Parham DM, Barr FG, Meltzer PS, Chen Y, Keller C. Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma Cancer Cell 2011 Feb;19(2):177-191. * 50.Holcomb JB, Weiskopf R, Champion H, Gould SA, Sauer RM, Brasel K, Bochicchio G, Cotton BA, Davis D, Dutton R, Hauser CJ, Hess JR, Hides GA, Knudson P, MacKenzie E, McGinnis RL, Michalek JE, Moore FA, Omert L, Pollock BH, Tortella B, Sugarman J, Schreiber MA, Wade CE. Challenges to effective research in acute trauma resuscitation: consent and endpoints Shock 2011 Feb;35(2):107-113. * 51.Corneille MG, Villa, C, Wolf SE, Michalek JE, Jung I, Wade CE, Myers JG, Dent DL, Mueller DL, Stewart RM. Time and Degree of Glycemic Derangement Are Associated with Increased Mortality in Trauma Patients in the Setting of Tight Glycemic Control Am J Surg 2010 Dec;200(6):832-837. * 52.Cohn SM, Pearl SM, Nowlin MU, Hernandez A, Guta C, Michalek JE, NIRF Clinical Trials Group. A Prospective Randomized Pilot Study of Near-Infrared Spectroscopy Directed Restricted Fluid Therapy versus Standard Fluid Therapy in Patients undergoing Elective Colorectal Surgery (in press) American Surgery 2010 Dec;76(12):1384-1392. * 53.Martinez CO, McHale MJ, Wells JT, Ochoa O, Michalek JE, McManus LM, Shireman PK. Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment. PMCID: PMC2944434 Am J Physiol Regul Integr Comp Physiol 2010 Sep;299(3):R832-R842. * 54.Prajapati SI, Martinez CO, Abraham J, McCleish AT, Michalek JE, McManus LM, Rubin B, Shireman PK, Keller C. Crimson carrier, a long-acting contrast agent for in vivo near-infrared imaging of injured and diseased muscle. PMCID: PMC2910161 Muscle and Nerve 2010 Aug;42(2):245-251. * 55.Schaffer BS, Grayson MH, Wortham JM, Kubicek CB, McCleish AT, Prajapati SI, Nelon LD, Brady MM, Jung I, Hosoyama T, Sarro LM, Hanes MA, Rubin BP, Michalek JE, Clifford CB, Infante AJ, Keller C. Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice. Mol Cancer Ther 2010 Aug;9(8):2354-2364. * 56.Gifford SM, Aidinian G, Clouse WD, Fox CJ, Porras CA, Jones WT, Zarzabal LA, Michalek JE, Propper BW, Burkhardt GE, Rasmussen TE. Effect of temporary shunting on extremity vascular injury: an outcome analysis from the Global War on Terror vascular injury initiative J Vasc Surg 2009 Sep;50(3):549-555.
* 57.Schecter A, Needham L, Pavuk M, Michalek JE, Colacino J, Ryan J, Papke O, Birnbaum L. Agent Orange expoure,Vietnam war veterans, and the risk of prostate cancer Cancer 2009 Jul;115(14):3369-3371. * 58.Stewart RM, Park PK, Hunt JP, McIntyre RC, McCarthy J, Zarzabal LA, Michalek JE. Less is more: improved outcomes in surgical patients with conservative fluid administration and central venous catheter monitoring. Journal of the American College of Surgeons 2009 May;208(5):725-735. * 59.Nishijo K, Chen QR, Zhang L, McCleish AT, Rodriguez A, Cho MJ, Prajapati SI, Gelfond JA, Chisholm GB, Michalek JE, Aronow BJ, Barr FG, Randall RL, Ladanyi M, Qualman SJ, Rubin BP, LeGallo RD, Wang C, Khan J, Keller C. Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. Cancer Res 2009 Apr;69(7):2902-2911. * 60.Sun D, Martinez C, Ochoa O, Ruiz-Willhite L, Bonilla JR, Centonze VE, Waite LL, Michalek JE, McManus LM, Shireman PK. Bone marrow-derived cell regulation of skeletal muscle regeneration. PMCID: PMC2630778 FASEB J 2009 Feb;23(2):382- 395. * 61.Sun D, Martinez CO, Ochoa O, Ruiz-Willhite L, Bonilla JR, Centonze VE, Waite LL, Michalek JE, McManus LM, Shireman PK. Bone marrow-derived cell regulation of skeletal muscle regeneration. FASEB J 2009 Feb;23(2):382-395. * 62.Russell IJ, Perkins AT, Michalek JE. Oxybate SXB-26 FMS Study Group. Sodium Oxybate [Xyrem] Improves Sleep and Relieves Pain in Patients with the Fibromyalgia Syndrome: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Clinical Trial. In submission to Arthritis and Rheumatism 2009 Jan;60(1):299-309. * 63.Cadena J, Levine DJ, Angel LF, Maxwell PR, Brady R, Sanchez JF, Michalek JE, Levine SM, Restrepo MI. Antifungal prophylaxis with voriconazole or itraconazole in lung transplant recipients: hepatotoxicity and effectiveness American Journal of Transplantation 2009;9(9):2085-2091. * 64.Prajapati SI, Martinez CO, Bahadur AN, Wu IQ, Zheng W, Lechleiter JD, McManus LM, Chisholm GB, Michalek JE, Shireman PK, Keller C. Near-infrared imaging of injured tissue in living subjects using IR-820. Mol Imaging 2009 Jan;8(1):45-54. * 65.Bingener J, Krishnegowda NK, Michalek JE. Immunologic parameters during NOTES compared with laparoscopy in a randomized blinded porcine trial Surg Endosc 2009 Jan;23(1):178-181. * 66.Bingener-Casey J, Buck, Lauren A, Schwesinger WH, Van Sickle KR, Michalek JE. Can Gastric Irrigation Prevent Infection During NOTES Mesh Placement? Epub 2008 Aug 13 J Gastrointest Surg 2008 Nov;12(11):2010-2014.
* 67.Taniguchi E, Nishijo K, McCleish AT, Michalek JE, Grayson MH, Infante AJ, Abboud HE, Legallo RD, Qualman SJ, Rubin BP, Keller C. PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma. Oncogene 2008 Nov;27(51):6550-6560. * 68.Boyd, T, Jung I, Van Sickle KR, Schwesinger WH, Michalek JE, Bingener-Casey J. Music Experience influences Laparoscopic Skills Performance Journal of the Society of Laparoendoscopic Surgeons 2008 Sep;12(3):292-294. * 69.Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, Williams KL, Park MS. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients Ann Surg 2008 Sep;248(3):447-458. * 70.Bingener J, Michalek J, Van Sickle K, Schwesinger W. Randomized blinded trial shows relative thrombocytopenia in natural orifice translumenal endoscopic surgery compared with standard laparoscopy in a porcine survival model Surg Endosc 2008 Sep;22(9):2067-2071. * 71.Bingener-Casey J, Michalek JE, Winston JH, Van Sickle KR, Haines V, Schwesinger WH, Lawrence VA. Randomized Blinded Trial Comparing the Cardiopulmonary Effects of NOTES with Standard Laparoscopy in a Porcine Survival Model Epub 2008 Apr 9 Surg Endosc 2008 Jun;195(2):1430-1434. * 72.Michalek JE, Pavuk M. Diabetes and Cancer in Veterans of Operation Ranch Hand after adjustment for calendar period, days of spraying, and time spent in Southeast Asia. The Journal of Occupational and Environmental Medicine 2008 Mar;50:330-340. * 73.Bingener J, Michalek JE, Winston J, Van Sickle K, Haines V, Schwesinger W, Lawrence V. Randomized blinded trial comparing the cardiopulmonary effects of NOTES with standard larparoscopy in a porcine survival model Surgical Endoscopy (DOI 10.1007/x00464-008-9898-8) 2008 Feb * 74.Bingener J, Cox D, Michalek JE, Mejia A. Can the MELD score predict perioperative morbidity for patients with liver cirrhosis undergoing laparoscopic cholecystectomy? Am Surg 2008 Feb;74(2):156-159. * 75.Lopez PP, Cohn SM, Popkin CA, Jackowski J, Michalek JE. The use of a computed tomography scan to rule out appendicitis in women of childbearing age is as accurate as clinical examination: a prospective randomized trial. Am Surg 2007 Dec;73(12):1232-1236. * 76.Ochoa O, Sun D, Reyes-Reyna SM, Waite LL, Michalek JE, McManus LM, Shireman PK. Delayed angiogenesis and VEGF production in CCR2-/- mice during impaired skeletal muscle regeneration. PMID: 17522124 Am J Physiol Regul Integr Comp Physiol 2007 Aug;293(2):651-661.
* 77.Bingener-Casey J, Buck L, Richards ML, Michalek JE, Schwesinger WH, Sirinek KR. Long-term outcomes in laparoscopic vs. open ventral hernia repair. Arch Surg 2007 Jun;142(6):562-567. * 78.Ochoa O, Sun, D, Reyes-Reyna, SM, Waite, LL, Michalek JE, McManus LM, Shireman PK. Delayed angiogenesis and VEGF production in CCR2 -/- mice during impaired skeletal muscle regeneration. Am J Physiol Reg Int Comp Physiol 2007 May;ePub * 79.Cohn SM, Price MA, Stewart RM, Michalek JE, Dent DL, McFarland MJ, Pruitt BA. A Crisis in the Delivery of Care to Patients with Brain injuries in South Texas. J Trauma 2007 Apr;62(4):951-963. 80.Taiwo OB, Russell IJ, Mignot E, Lin L, Michalek JE, Haynes W, Xiao Y, Zeitzer JM, Larson AA. Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome. Sleep Med 2007 Apr;8(3):260-265. * 81.Shireman PK, Contreras-Shannon V, Ochoa O, Karia BP, Michalek JE, McManus LM. MCP-1 deficiency causes altered inflammation with impaired skeletal muscle regeneration. J Leukoc Biol 2007 Mar;81:775-785. * 82.Contreras-Shannon V, Ochoa O, Reyes-Reyna SM, Sun D, Michalek JE, Kuziel WA, McManus LM, Shireman PK. Fat accumulation with altered inflammation and regeneration in skeletal muscle of CCR2-/- mice following ischemic injury. PMID: 17020936 Am J Physiol Cell Physiol 2007 Feb;292(2):c953-c967. * 83.Ketchum NS, Michalek JE, and Pavuk M. Mortality, length of life, and physical examination attendance in participants of the Air Force Health Study Military Medicine 2007 Jan;172(1):53-57. * 84.Bingerer J, Buck L, Richards M, Michalek JE, Schwesinger W, Sirinek K. Long-term Outcomes in Laparoscopic vs Open Ventral Hernia Repair Archives of Surgery 2007 Jan;142:562-567. * 85.Fujiyoshi P, Michalek JE, and Matsumura F. Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in US Air Force veterans of the Vietnam War Environmental Health Perspectives 2006 Nov;114(11):1-7. * 86.Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans Environmental Health Perspectives 2006 Nov;114(11):1649-1654. * 87.Fujiyoshi PT, Michalek JE, Matsumura F. Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air force veterans of the Vietnam war. Environ Health Perspect 2006 Nov;114(11):1677-1683.
* 88.Boyle SH, Michalek JE, Suarez EC. Covariation of psychological attributes and incident coronary heart disease in U.S. Air Force veterans of the Vietnam war. Psychosom Med 2006 Nov;68(6):844-850. * 89.Cohn SM, Price MA, Stewart RM, Michalek JE, Dent DL, Pruitt BA. A crisis in the delivery of care to brain injured patients Proceedings of the Texas Surgical Society 2006 Oct * 90.Kaats GR, Michalek JE, Preuss HG. Evaluating efficacy of a chitosan product using a double-blinded, placebo-controlled protocol Journal of the American College of Nutrition 2006 Oct;25(5):389-394. * 91.Boyle SH, Suarez EC and Michalek JE. Covariation of Psychological Attributes and Incident coronary heart disease. Psychosomatic Medicine 2006;68(6):844-850. * 92.Ketchum NS, Michalek JE. Postservice mortality of Air Force veterans occupationally exposed to herbicides during the Vietnam War: 20-year follow-up results Military Medicine 2005 May;170(5):406-413. * 93.Pavuk M, Michalek JE, Schecter A, Ketchum NS, Akhtar FZ, Fox KA. Did TCDD exposure or service in Southeast Asia increase the risk of cancer in air force Vietnam veterans who did not spray agent orange? J Occup Environ Med 2005 Apr;47(4):335- 342. * 94.Kingman, Albert, Albers, James W, Arezzo, Joseph C, Garabrant, David H, Michalek JE. Amalgam exposure and neurological function Neurotoxicology 2005 Mar;26(2):241-255. * 95.Whitney EJ, Krasuski RA, Personius BE, Michalek JE, Maranian AM, Kolasa MW, Monick E, Brown BG, Gotto AM. A randomized trial of a strategy for increasing high- density lipoprotein cholesterol levels: effects on progression of coronary heart disease and clinical events. Ann Intern Med 2005 Jan;142(2):95-104. * 96.Ketchum NS and Michalek JE. Post-service mortality of Air Force veterans occupationally exposed to herbicides during the Vietnam War. Military Medicine 2005;170(5):406-413. * 97.Emond C, Michalek J, Birnbaum LS, DeVito MJ. Comparison of the use of a physiologically based pharmacokinetic model and a classical pharmacokinetic model for dioxin exposure assessments Environmental Health Perspectives 2005;113(12):1666-1668. * 98.Kingman A, Albers JW, Arezzo JC, Garabrant DH, Michalek JE. Amalgam exposure and neurological function. Neurotoxicology 2005;26(2):241-255. * 99.Pavuk M, Michalek JE, Schecter A, Ketchum NS, Akhtar FZ, Fox KA. Did dioxin or service in Southeast Asia increase the risk of cancer in Air Force Vietnam veterans
who did not spray Agent Orange? Journal of Occupational and Environmental Medicine 2005;47(4):335-342. * 100.Kern PA, Said S, Jackson WG, Michalek JE. Insulin sensitivity following agent orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p- dioxin. J Clin Endocrinol Metab 2004 Sep;89(9):4665-4672. * 101.Akhtar FZ, Garabrant DH, Ketchum NS, Michalek JE. Cancer in US Air Force veterans of the Vietnam War. J Occup Environ Med 2004 Feb;46(2):123-136. * 102.Xiao Y, Russell IJ, Michalek JE, and Lawrence R. Changes in hyaluronate levels correlate with subjective stiffness in fibromyalgia. (In Submission) 2004 Feb * 103.Pavuk M, Schecter AJ, Akhtar FZ, Michalek JE. Serum 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) levels and thyroid function in Air Force veterans of the Vietnam War. Ann Epidemiol 2003 May;13(5):335-343. * 104.Michalek JE, Barrett DH, Morris RD, Jackson WG. Serum dioxin and psychological functioning in U.S. Air Force veterans of the Vietnam War. Mil Med 2003 Feb;168(2):153-159. * 105.Michalek JE, Ketchum NS, Tripathi RC. Diabetes mellitus and 2,3,7,8- tetrachlorodibenzo-p-dioxin elimination in veterans of Operation Ranch Hand. J Toxicol Environ Health A 2003 Feb;66(3):211-221. * 106.Michalek JE, Pirkle JL, Needham LL, Patterson DG, Caudill SP, Tripathi RC, Mocarelli P. Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand. J Expo Anal Environ Epidemiol 2002 Jan;12(1):44- 53. * 107.Steenland K, Calvert G, Ketchum N and Michalek JE. Dioxin and diabetes mellitus: an analysis of the combined NIOSH and Ranch Hand data. Occupational and Environmental Medicine 2001 Oct;58:641-648. * 108.Barrett DH, Morris RD, Akhtar FZ, Michalek JE. Serum dioxin and cognitive functioning among veterans of Operation Ranch Hand. Neurotoxicology 2001 Aug;22(4):491-502. * 109.Michalek JE, Akhtar FZ, Arezzo JC, Garabrant DH, Albers JW. Serum dioxin and peripheral neuropathy in veterans of Operation Ranch Hand. Neurotoxicology 2001 Aug;22(4):479-490. * 110.Michalek JE, Ketchum NS, Longnecker MP. Serum dioxin and hepatic abnormalities in veterans of Operation Ranch Hand. Ann Epidemiol 2001 Jul;11(5):304-311.
* 111.Guo X, Longnecker MP, Michalek JE. Relation of serum tetrachlorodibenzo-p-dioxin concentration to diet among veterans in the Air Force Health Study with background- level exposure. J Toxicol Environ Health A 2001 Jun;63(3):159-172. * 112.Jackson WG, Michalek JE. Temporal changes in TCDD levels in 1419 Air Force Vietnam-era veterans not occupationally exposed to herbicides. J Expo Anal Environ Epidemiol 2001;11(1):50-55. * 113.Michalek JE, Akhtar FZ, Longnecker MP, Burton JE. Relation of serum 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) level to hematological examination results in veterans of Operation Ranch Hand. Arch Environ Health 2001;56(5):396-405. * 114.Larson AA, Giovengo SL, Russell IJ, Michalek JE. Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways. Pain 2000 Aug;87(2):201-211. * 115.Longnecker MP, Michalek JE. Serum dioxin level in relation to diabetes mellitus among Air Force veterans with background levels of exposure. Epidemiology 2000 Jan;11(1):44-48. * 116.Selvavel K, Nanthakumar A and Michalek JE. On the estimation of P(X less than Y) for truncated bivariate exponential distribution and its application. Journal of Applied Statistical Science 2000;10:47-56. * 117.Mehrotra KG, Kulkarni PM, Tripathi RC, and Michalek JE. Maximum likelihood estimation for longitudinal data with truncated observations. Statistics in Medicine 2000;19:2975-2988. * 118.Russell IJ, Vipraio GA, Michalek JE, Craig FE, Kang YK, Richards AB. Lymphocyte markers and natural killer cell activity in fibromyalgia syndrome: effects of low-dose, sublingual use of human interferon-alpha. J Interferon Cytokine Res 1999 Aug;19(8):969-978. * 119.Russell IJ, Michalek JE, Kang YK, Richards AB. Reduction of morning stiffness and improvement in physical function in fibromyalgia syndrome patients treated sublingually with low doses of human interferon-alpha. J Interferon Cytokine Res 1999 Aug;19(8):961-968. * 120.Ship JA, Fox PC, Michalek JE, Cummins MJ, Richards AB. Treatment of primary Sjogren's syndrome with low-dose natural human interferon-alpha administered by the oral mucosal route: a phase II clinical trial. IFN Protocol Study Group. J Interferon Cytokine Res 1999 Aug;19(8):943-951. * 121.Longnecker MP and Michalek JE. Weight history, glucose intolerance, and insulin levels in middle-aged Swedish men. Am J Epidemiol 1999 Aug;150(4):430-432.
122.Longnecker MP, Michalek JE. Re: "Weight history, glucose intolerance, and insulin levels in middle-aged Swedish men". Am J Epidemiol 1999 Aug;150(4):430-432. * 123.Michalek JE, Tripathi RC. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 15-year follow-up. J Toxicol Environ Health A 1999 Jul;57(6):369-378. * 124.Michalek JE, Ketchum NS, Check IJ. Serum dioxin and immunologic response in veterans of Operation Ranch Hand. Am J Epidemiol 1999 Jun;149(11):1038-1046. * 125.Michalek JE, Akhtar FZ, Kiel JL. Serum dioxin, insulin, fasting glucose, and sex hormone-binding globulin in veterans of Operation Ranch Hand. J Clin Endocrinol Metab 1999 May;84(5):1540-1543. * 126.Ketchum NS, Michalek JE, Burton JE. Serum dioxin and cancer in veterans of Operation Ranch Hand. Am J Epidemiol 1999 Apr;149(7):630-639. * 127.Michalek JE, Ketchum NS, Akhtar FZ. Postservice mortality of US Air Force veterans occupationally exposed to herbicides in Vietnam: 15-year follow-up. Am J Epidemiol 1998 Oct;148(8):786-792. * 128.Michalek JE, Rahe AJ, Boyle CA. Paternal dioxin and the sex of children fathered by veterans of Operation Ranch Hand. Epidemiology 1998 Jul;9(4):474-475. * 129.Michalek JE, Rahe AJ, Boyle CA. Paternal dioxin, preterm birth, intrauterine growth retardation, and infant death. Epidemiology 1998 Mar;9(2):161-167. * 130.van der Molen GW, Kooijman SA, Michalek JE, Slob W. The estimation of elimination rates of persistent compounds: a re-analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in Vietnam veterans. Chemosphere 1998;37(9-12):1833-1844. * 131.Burton JE, Michalek JE, Rahe AJ. Serum dioxin, chloracne, and acne in veterans of Operation Ranch Hand. Arch Environ Health 1998;53(3):199-204. * 132.Michalek JE, Rahe AJ, Kulkarni PM, Tripathi RC. Levels of 2,3,7,8-tetrachlorodibenzo- p-dioxin in 1,302 unexposed Air Force Vietnam-era veterans. J Expo Anal Environ Epidemiol 1998;8(1):59-64. * 133.Kulkarni PM, Tripathi RC, Michalek JE. Maximum (Max) and Mid-P confidence intervals and p values for the standardized mortality and incidence ratios. Am J Epidemiol 1998 Jan;147(1):83-86. * 134.Michalek JE, Tripathi RC, Kulkarni PM, Gupta PL and Selvavel K. Correction for bias introduced by truncation in pharmacokinetic studies of environmental contaminants. Environmetrics 1998;9:165-174.
* 135.Mazur A and Michalek JE. Marriage, divorce, and male testosterone. Social Forces 1998;77:315-330. * 136.Michalek JE. Letter to the editor. Epidemiology 1998;9:359-360. * 137.Schecter AJ, Michalek JE, May J and Papke O. Dioxin and dibenzofuran congeners in 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, and Agent Orange. Organohalogen Compounds 1998;36:285-288. * 138.Michalek JE, Caudill SP, Tripathi RC. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up. Erratum. J Toxicol Environ Health 1997 Dec;52(6):557-558. * 139.Henriksen GL, Ketchum NS, Michalek JE, Swaby JA. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. Epidemiology 1997 May;8(3):252-258. * 140.Henriksen GL, Michalek JE, Swaby JA, Rahe AJ. Serum dioxin, testosterone, and gonadotropins in veterans of Operation Ranch Hand. Epidemiology 1996 Jul;7(4):352- 357. * 141.Michalek JE, Pirkle JL, Caudill SP, Tripathi RC, Patterson DG, Needham LL. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up. J Toxicol Environ Health 1996 Feb;47(3):209-220. * 142.Michalek JE, Tripathi RC, Kulkarni PM, Pirkle JL. The reliability of the serum dioxin measurement in veterans of Operation Ranch Hand. J Expo Anal Environ Epidemiol 1996;6(3):327-338. * 143.Henriksen GL and Michalek JE. Letter to the editor. Epidemiology 1996;7(4):454-455. * 144.Russell IJ, Orr MD, Michalek JE, Nyberg F and Eriksson U. Substance P (SP), SP endopeptidase activity (SPE), and SP N-terminal peptide (SP1-7) in fibromyalgia syndrome cerebrospinal fluid (CSF). Third World Congress on Myofascial Pain and Fibromyalgia (abst) 1995 Jul * 145.Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995 May;22(5):953-958. * 146.Michalek JE, Wolfe WH, Miner JC, Papa TM, Pirkle JL. Indices of TCDD exposure and TCDD body burden in veterans of Operation Ranch Hand. J Expo Anal Environ Epidemiol 1995;5(2):209-223. * 147.Wolfe WH, Michalek JE, Miner JC, Rahe AJ, Moore CA, Needham LL, Patterson DG. Paternal serum dioxin and reproductive outcomes among veterans of Operation Ranch Hand. Epidemiology 1995 Jan;6(1):17-22.
* 148.Tiwary CM, Michalek JE. Incidence of diabetes among dependents of the U.S. military forces admitted to U.S. Army treatment facilities, 1971-1991. Diabetes Care 1995 Jan;18(1):90-92. * 149.Wolfe WH, Michalek JE, Miner JC, Pirkle JL, Caudill SP, Patterson DG, Needham LL. Determinants of TCDD half-life in veterans of Operation Ranch Hand. J Toxicol Environ Health 1994 Apr;41(4):481-488. * 150.Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE, Lopez Y and Mackillip F. Elevated cerebral spinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis and Rheumatism 1994;37:1593-1601. * 151.Russell IJ, Michalek JE, Vipraio GA, Fletcher EM, Javors MA and Bowden CA. Reply to letter regarding manuscript entitled: Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome Journal of Rheumatology 1993;20:1986-1988. * 152.Wolfe WH, Miner JC, Michalek JE. Immunological parameters in current and former US Air Force personnel. Vaccine 1993 Jan;11(5):545-547. * 153.Wolfe WH, Miner JC, Michalek JE. Immunological parameters in current and former US Air Force personnel. Vaccine 1992;11(5):545-547. * 154.Michalek JE, Tripathi RC, Caudill SP, Pirkle JL. Investigation of TCDD half-life heterogeneity in veterans of Operation Ranch Hand. J Toxicol Environ Health 1992 Jan;35(1):29-38. * 155.Caudill SP, Pirkle JL, Michalek JE. Effects of measurement error on estimating biological half-life. J Expo Anal Environ Epidemiol 1992;2(4):463-476. * 156.Russell IJ, Michalek JE, Vipraio GA, Fletcher EM, Javors MA, Bowden CA. Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol 1992 Jan;19(1):104-109. * 157.Wolfe WH, Michalek JE, Miner JC, Pirkle J, Caudill S, Needham L and Patterson Jr DG. Dioxin half-life in veterans of Operation Ranch Hand. Organohalogen Compounds 1992;10:239-242. * 158.Wolfe WH, Michalek JE, Miner JC, Needham LL and Patterson Jr, DG. Diabetes versus dioxin body burden in veterans of Operation Ranch Hand. Organohalogen Compounds 1992;10:279-282. * 159.Wolfe WH, Michalek JE, Miner JC, Rahe A, Moore CA, Needham LL and Patterson Jr DG. Reproductive outcomes versus paternal dioxin body burden in veterans of Operation Ranch Hand. Organohalogen Compounds 1992;10:283-286.
* 160.Russell IJ, Russell SJ, Cuevas RE, Michalek JE. Early life traumas and confiding in fibromyalgia syndrome (FS). Scandanavian Journal of Rheumatology 1992;94(S14) * 161.Russell IJ, Vipraio GA, Michalek JE and Lopez YG. Insulin-like growth factor (IGF1) in fibromyalgia (FS), rheumatoid arthritis (RA), osteoarthritis (OA) and healthy normal controls (NC): Roles of diagnosis, age, sex and ethnic origin. Arthritis and Rheumatism 1992;35(S160) * 162.Russell IJ, Michalek JE, Vipraio GA, Lawrence VA, Lessard JA, Briggs BT. Automated reading of joint space on osteoarthritis X-rays: Correlation with clinical manifestations. Arthritis and Rheumatism 1992;35(S133) * 163.Russell IJ, Michalek JE, Lawrence VA, Lessard JA, Briggs BT and May GS. A randomized, placebo (PL) and no-intervention (NI) controlled, trial of intra-articular (IA) 1% sodium hyaluronate (HA) in the treatment of knee osteoarthritis. Arthritis and Rheumatism 1992;35(S132) * 164.Russell IJ, Fletcher EM, Michalek JE, McBroom PC, Hester GG. Treatment of primary fibrositis/fibromyalgia syndrome with ibuprofen and alprazolam. A double-blind, placebo-controlled study. Arthritis Rheum 1991 May;34(5):552-560. * 165.Michalek JE, Wolfe WH, Miner JC. Health status of Air Force veterans occupationally exposed to herbicides in Vietnam. II. Mortality. JAMA 1990 Oct;264(14):1832-1836. * 166.Wolfe WH, Michalek JE, Miner JC, Rahe A, Silva J, Thomas WF, Grubbs WD, Lustik MB, Karrison TG, Roegner RH. Health status of Air Force veterans occupationally exposed to herbicides in Vietnam. I. Physical health. JAMA 1990 Oct;264(14):1824- 1831. * 167.Russell IJ, Michalek JE, Vipraio GA, Fletcher EM, Wall K. Serum amino acids in fibrositis/fibromyalgia syndrome. J Rheumatol Suppl 1989 Nov;19:158-163. * 168.Michalek JE, Mihalko D, Tripathi RC. Cautions on the reanalysis of epidemiologic databases. Stat Med 1989 Jun;8(6):653-664. * 169.Pirkle JL, Wolfe WH, Patterson DG, Needham LL, Michalek JE, Miner JC, Peterson MR, Phillips DL. Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam Veterans of Operation Ranch Hand. J Toxicol Environ Health 1989;27(2):165- 171. * 170.Michalek JE. The value of epidemiology. Applied Industrial Hygiene, Special Issue 1989:68-72. * 171.Russell IJ, Fletcher EM, Tsui J and Michalek JE. Comparisons of rheumatoid arthritis and fibrositis/fibromyalgia syndrome using functional and psychological outcome measures. Arthritis and Rheumatism 1989;32(S70)
* 172.Russell IJ, Fletcher EM, Michalek JE, McBroom PC and Hester GG. Efficacy and safety of ibuprofen and alprazolam in the treatment of primary fibrositis/fibromyalgia syndrome. Arthritis and Rheumatism 1989;32(S69) * 173.Russell IJ, Michalek JE, Vipraio GA, Fletcher EM and Wall K. Serum amino acids in fibrositis/fibromyalgia syndrome. Arthritis and Rheumatism 1989;32(S70) * 174.Wolfe WH, Michalek JE, Miner JC, Patterson DG, Needham LL and Pirkle JL. Serum dioxin levels in Air Force Health Study participants preliminary report. Morbidity Mortality Weekly Report 1988;37:309-311. * 175.Russell IJ, Vipraio GA, Michalek JE and Fletcher E. Abnormal T cell subpopulations in fibrositis syndrome. Arthritis and Rheumatism 1988:S99-S99. * 176.Russell IJ, Vipraio GA, Tovar Z, Michalek JE and Fletcher E. Abnormal natural killer cell activity in fibrositis syndrome is responsive in vitro to IL-2. Arthritis and Rheumatism 1988:S24-S24. * 177.Gupta RC, Tripathi RC, Michalek JE and White T. An exact test for the mean of a normal distribution with a known coefficient of variation. Computational Statistics and Data Analysis 1986;3:219-226. * 178.Gupta RC and Michalek JE. On the relationship between the proportional hazard and accelerated failure time models in survival analysis. Statistics and Probability Letters 1985;3:231-234. * 179.Michalek JE, Mihalko D and White T. A Monte Carlo comparison of logrank, Wilcoxon and normal scores procedures on matched and censored data. Communications in Statistics 1985;14(2):449-465. * 180.Michalek JE and Mihalko D. Linear rank procedures for matched data. Biometrics 1984;40:487-491. * 181.Gupta RC, Mehrotra KG and Michalek JE. A small sample test for an absolutely continuous bivariate exponential model. Communications in Statistics 1984;13(14):1735-1740. * 182.Gupta RC and Michalek JE. On Gehan‘s Wilcoxon extension and the accelerated failure time model. Communications in Statistics 1984;13(5):563-566. * 183.Gupta RC and Michalek JE. On the determination of reliability functions via the TTT transform. IEEE Transactions on Reliability 1984;R-(34):175-176. * 184.Michalek JE, Mihalko D. On the use of logrank scores in the analysis of litter-matched data on time to tumour appearance. Stat Med 1983 Jul;2(3):315-326.
* 185.Mehrotra KG, Michalek JE, Mihalko D, White T. Score computation for linear rank procedures. Journal of Statistical Computation and Simulation 1983;16:201-211. * 186.Keating JP, Michalek JE and Riley JT. A note on the optimality of the Karhunen-Loeve expansion. Pattern Recognition Letters 1983;1:203-204. * 187.Eisenberg B, Decosse J, Harford F and Michalek JE. Carcinoma of the colon and rectum: the natural history reviewed in 1704 cases. Cancer 1982;49:1131-1134. * 188.Mehrotra KG, Michalek JE and Mihalko D. A relationship between two forms of linear rank procedures for censored data. Biometrika 1982;69:674-676. * 189.Michalek JE, Tripathi RC. The effect of errors in diagnosis and measurement on the estimation of the probability of an event. Journal of the American Statistical Association 1980;75:713-721. * 190.Hensler GL, Mehrotra KG, Michalek JE. A goodness of fit test for multivariate normality. Communications in Statistics 1977;A6(1):33-41. * 191.Michalek JE. Uniform convergence of an empirical CDF based on a relatively small number of order statistics. Communications in Statistics 1976;5(3):241-250. * 192.Hensler GL, Mehrotra KG, Michalek JE. A note on some exact efficiency calculations for survival distributions. Biometrika 1976;64:635-637. Papers Submitted * 1.Muir T, Michalek JE. Contrasting toxicology and epidemiology on safe levels of persistent organic pollutants 2013 Feb PRESENTATIONS: 02/2005 On the Disposition of the Air Force Health Study: An Overview, Board Room NAS Building, Washington, DC (Invited Speaker) 10/2002 Like morning stiffness in rheumatoid arthritis, morning stiffness in fibromyalgia is related to serum hyaluronic acid., American College of Rheumatology, New Orleans, LA (Co-Presenter)
10/2002 Therapy with a central alpha-2-adrenergic agonist [tizanidine] decreases cerebrospinal fluid substance P, and may reduce serum hyaluronic acid as it improves the clinical symptoms of the fibromyalgia syndrome., American College of Rheumatology, New Orleans, LA (Co-Presenter) 10/2002 Correlation of Anti-Polymer Antibodies with Clinical Measures in Fibromyalgia Syndrome., American College of Rheumatology, New Orleans, LA (Co-Presenter) 04/2002 Veterans and Agent Orange: Update 2002 (2003), National Academy of Sciences, Washington, DC (Sole Presenter) Details: First Public Meeting in the 2002 Update Series: "Recent Data from Ranch Hand Studies" 04/2002 Dioxins and Dioxin-like Compounds in the Food Supply: Strategies to Decrease Exposure (2003), National Academy os Sciences (Sole Presenter) Details: Workshop #2–Implication of Dioxin in the Food Supply, Session on Accumulation and Elimination of Dioxins in Humans: “Kinetics of Dioxin Elimination in the Ranch Hand Cohort” 04/2002 Workshop #2-Implication of Dioxin in the Food Supply, Session on Accumulation and Elimination of Dioxins in Humans: "Kinetics of Dioxin Elimination in the Ranch Hand Cohort" (Invited Speaker) 01/2002 Alpha-2 adrenergic agonists: evidence and experience examined, Round Table Series 75, The Royal Society of Medicine Press, Ltd (Co-Presenter) 06/2000 Public Workshop 2: "Dioxin and Diabetes in Ranch Hand Veterans", National Academy of Sciences, Washington, DC (Sole Presenter)
03/2000 Agent Orange:Status of the Air Force Ranch Hand Study, House of Representatives subcommittee on National Security, Veterans Affairs, and International Relations, of the Committee on Government Reform, United States Congress (Invited Speaker) Details: Defended the study against claims that the Air Force, the Food and Drug Administration, and the National Academy of Sciences had collaborated to encumber scientific aspects of the study 07/1999 Veterans and Agent Orange: Herbicide/Dioxin Exposure and Type 2 Diabetes (2000), National Academy of Sciences, Washington, DC (Sole Presenter) Details: Public Workshop 1: "Diabetes and TCDD in the Air Force Health Study" 09/1996 Health Effects in Veterans Exposed to Agent Orange in Vietnam, Committee on Veteran's Affairs, United States Senate (Invited Speaker) Details: Information gathering hearing at which a short summary of results and response to questions from the Committee. 08/1996 Characteristics of the elevated spinal fluid substance P in fibromyalgia syndrome., 8th World Congress on Pain, Vancouver, BC, Canada (Co-Presenter) 04/1996 Health Effects in Children of Individuals Exposed to Agent Orange in Vietnam, Committee on Veterans' Affairs Subcommittee on Hospitals and Health Care, United States House of Representatives (Invited Speaker) 01/1994 Veterans and Agent Orange: Health Effects of Herbicides Used in Vietnam, National Academy of Sciences (Sole Presenter) 12/1992 Scientific Workshop on Exposure Assessment, Session 4: Biomarkers for Exposure Assessment, National Academy of Sciences (Sole Presenter)
11/1989 A rebuttal to "How the military misled Vietnam veterans and their families about the health risks of Agent Orange", House and Senate Committees on Veterean's Affairs staffers, United States Congress (Invited Speaker) Details: Defended the Air Force Health Study against a claim that study investigators had withheld information. 05/1988 A metabolic basis for fibrositis syndrome (FS): The serotonin deficiency hypothesis., ARA Meeting, Nonarticular Rheumatism Study Group (NARSG) Meeting, Houston, TX (Co- Presenter) Details: Accepted for presentation. 05/1988 Agent Orange Legislation and Oversight Hearing, Committee on Veterans' Affairs, One Hundredth Congress, Second Session on S.1692, United States Senate (Invited Speaker) Details: The proposed "Agent Orange Disability Benefits Act of 1987"; S. 1781, The Proposed "Veterans Agent Orange Disability Act of 1987"; and Agent Orange Oversight Issues May 12, 1988. U.S. Government Printing Office, Washington: 1989 Hearing to assess Federal efforts to address the Agent Orange issue. RESEARCH GRANTS: Project #: Funding Agency: VA Title: IPAA for Joel E Michalek(Cadena) Status: Active Period: 06/2014 - 05/2016 Role: Co-Investigator % Effort: 3 Total Costs: $6,788.00 Grant Detail: Failure to isolate patients with pulmonary tuberculosis as a patient safety issue: Defining the problem and estimating its associated costs Despite advances in its control and prevention, tuberculosis (TB) is an important patient safety issue in the US. Texas and other three states account for over half of the US cases. Healthcare Associated TB exposure cohorts continue to occur despite implementation of the CDC’s recommendations for infection prevention, causing significant costs for healthcare systems. However, recent data on factors predicting the clinical features of TB cases leading to exposures, and the costs of contact tracings for healthcare systems are not available. This should be researched in order ensure a safe environment for patients.
Project #: 3UL1TR001120-01 Funding Agency: NIH/NCRR Title: Institute For Integration of Medicine & Science: A Partnership to Improve Health(3UL1TR00120-01/Biostatistics)(Clark, Robert) Status: Complete Period: 05/2008 - 04/2015 Role: Co-Investigator % Effort: 20 Total Costs: $424,158.00 Grant Detail: Our mission is to achieve optimal integration of clinical and translational research, education, training, and career development across all UTHSCSA schools and among our partner organizations in the South Texas region. IIMS will focus existing and newly developing resources and intellectual capital on advancing the discipline of clinical and translational research for the improvement of human health. Key function working groups have developed many innovative approaches to providing optimal support for IIMS investigators and programs. Distinctive features of IIMS include: 1) thriving partnerships with key public and private organizations (academic, health care, public health, military), 2) major investments in research resources and infrastructure, 3) the largest cadre of military health care and biomedical research operations in the US, 4) one of the world’s largest primate research colonies, 5) a 46,000 square mile service area populated by predominantly Hispanic residents comprising some of the country’s poorest people, plagued by high rates of health disparities, providing an opportunity, challenge and obligation for us to make a significant impact on human health. Project #: 5M01 RR 001346-2 Funding Agency: NIH Title: General Clinical Research Center: Biostat Core (PI: Clark, Robert) Status: Complete Period: 12/2003 - 04/2009 Role: Co-Investigator % Effort: 20 Total Costs: $726,226.00 Grant Detail: The Biostatistics and Informatics Core of the Frederic C. Bartter General Clinical Research Center (GCRC) provides bio-statistical and data management support for protocols and participates in Educational/training activities for junior investigators. Federal Project #: W911QY-14-1-0005 Funding Agency: Army Med Research Acquisition Activity Title: Evaluation of the Efficacy of a Novel Soft Tissue Clamp Status: Complete Period: 09/2014 - 03/2015 Role: Contributor % Effort: 10 Total Costs:
Grant Detail: This is a non-inferiority study of a novel, FDA approved, externally-applied, soft-tissue clamp (iTClamp®, Innovative Trauma Care, Inc., San Antonio, TX, USA) as compared to a properly- placed hasty tourniquet for intact extremity penetrating trauma hemorrhage control, during the “care under fire” phase of the Tactical Combat Casualty Care (TCCC) paradigm. The goal is to determine whether the temporary wound closure clamp provides hemorrhage control comparable to a hasty tourniquet when applied to a non-amputation arterial extremity hemorrhage model. Project #: RP 140685 Funding Agency: CPRIT Title: Modulation of Autophagy - Phase II Study Status: Active Period: 08/2014 - 08/2015 Role: Contributor % Effort: 3 Total Costs: Grant Detail: This will be a randomized, controlled phase II clinical trial of pts with histological documentation of primary colon or rectal adenocarcinoma with metastases, who have received locally and currently approved standard therapies, excluding RGF. Pts will be randomized to RGF or VOR/HCQ, and crossover will be allowed after first progression on the initial therapy. In the single- arm phase study, VOR/HCQ was given daily in 3-week cycles. In this proposed study, we will give VOR/HCQ daily in 4-week cycles, such that this is comparable to the 4-week cycle of RGF (daily for 3 weeks, 1 week off). Project #: 1 R01 FD004400-0 Funding Agency: FDA Title: Phase 2 Study of TH-302 for the Treatment of Glioblastoma Status: Active Period: 08/2014 - 06/2015 Role: Contributor % Effort: 3 Total Costs: Grant Detail: This application attempts to challenge the current clinical paradigm [38] in glioblastoma of uniform treatment for all patients with an anitangiogenic agent to a more individualized treatment regimen based on molecular biomarkers that define the individual tumor’s level of hypoxia, and uses that hypoxia as a target of therapy. This approach is novel, and attempts to refine the potential integration of molecular imaging and biomarker analysis as predictive tools. Moreover, this proposal makes use of a new category of therapeutic; the hypoxia activated pro-drug TH-302, in an attempt to improve survival of an orphan disease with dismal outcomes. Project #: 2 P30 CA054174-1 Funding Agency: NIH/NCRR Title: Cancer Therapy and Research Center at UTHSCSA/Cancer Center Admin(Thompson) Status: Active Period: 08/2009 - 07/2014 Role: Co-Investigator % Effort: 5 Total Costs: $1,029,650.00
Grant Detail: This is a P30 Cancer Center Support Grant at the University of Texas Health Science Center at San Antonio. This grant provides funding for the conduct of cancer clinical trials, prevention studies and assistance with statistical design and analysis of translational cancer research projects. Specifically, this is for support of the biostatistics and medical informatics core which has the following aims: provide flexible, cost-efficient services to CTRC basic, clinical and translational researchers; provides services to aid in the administration of the CTRC including monitoring and reporting functions for compliance with local and Federal regulatory requirements, quality assurance review, preparation of reports and analyses for administrative meetings; to provide informatics components for the Protocol Review Committee, the Data Safety Monitoring Committee and to provide statistical assistance with the development and conduct of clinical protocol-based research. Project #: 2 P30 CA054174-1 Funding Agency: NIH/NCI Title: Cancer Therapy and Research Center/Cancer Center Admin Status: Complete Period: 08/2009 - 07/2013 Role: Consultant % Effort: 6 Total Costs: Grant Detail: This is a P30 Cancer Center Support Grant at the University of Texas Health Science Center at San Antonio. This grant provides funding for the conduct of cancer clinical trials, prevention studies and assistance with statistical design and analysis of translational cancer research projects. Specifically, this is for support of the biostatistics and medical informatics core which has the following aims: provide flexible, cost-efficient services to SACI basic, clinical and translational researchers; provides services to aid in the administration of the SACI including monitoring and reporting functions for compliance with local and Federal regulatory requirements, quality assurance review, preparation of reports and analyses for administrative meetings; to provide informatics components for the Protocol Review Committee, the Data Safety Monitoring Committee and to provide statistical assistance with the development and conduct of clinical protocol-based research. Project #: W81XWH-08-2-0109 Funding Agency: Psychological Health and TBI Research Program, Congressionally Directed Medical Research Program Title: The STRONG STAR Multidisciplinary PTSD Research Consortium Status: Complete Period: 09/2008 - 08/2015 Role: Consultant % Effort: Total Costs: $35,000,000.00 Grant Detail: This is a multidisciplinary and multi-institutional proposal to establish a PTSD research consortium in San Antonio focused on the development and evaluation of prevention and treatment programs for combat-related PTSD in active-duty military personnel and recently discharged military veterans. Project #: 1UL1RR025767-01 Funding Agency: NIH/NCRR Title: Institute for Integration of Medicine & Science: A Partnership to Improve Health Status: Complete
Period: 05/2008 - 04/2013 Role: Consultant % Effort: 15 Total Costs: Grant Detail: Prinicipal Investigator: Robert Clark, MD Our mission is to achieve optimal integration of clinical and translational research, education, training, and career development across all UTHSCSA schools and among our partner organizations in the South Texas region. IIMS will focus existing and newly developing resources and intellectual capital on advancing the discipline of clinical and translational research for the improvement of human health. Meaningful bidirectional community participation has promoted buy-in from all stakeholders and will remain a key principle as IIMS continues to evolve. IIMS partners have brought together major talent and a broad array of resources to create synergies that add value to all participating organizations, residents of our region and the CTSA network. Key function working groups have developed many innovative approaches to providing optimal support for IIMS investigators and programs. Distinctive features of IIMS include: 1) thriving partnerships with key public and private organizations (academic, health care, public health, military), 2) major investments in research resources and infrastructure, 3) the largest cadre of military health care and biomedical research operations in the US, 4) one of the world’s largest primate research colonies, 5) a 46,000 square mile service area populated by predominantly Hispanic residents comprising some of the country’s poorest people, plagued by high rates of health disparities, providing an opportunity, challenge and obligation for us to make a significant impact on human health. Project #: R01CA 133229-01 Funding Agency: NIH/NCI Title: Therapeutic Targets in Alveolar Rhabdomyosarcoma Status: Complete Period: 04/2008 - 03/2013 Role: Co-Investigator % Effort: 5 Total Costs: $1,539,045.00 Grant Detail: The primary objective for this project will be to delineate the PDGFR-A signaling pathway to rhabdomyosarcome by functional testing in vitro with the second aim to determine the pathophysiologicl impact of specific and exclusive PDGFR-A blockade for rhabdomyosarcome in vivo. Project #: 5K23DA022297-04 Funding Agency: NIDA Title: Treatment of Opioid Dependence and Chronic Pain Status: Complete Period: 04/2008 - 03/2013 Role: Consultant % Effort: Total Costs: Grant Detail: The goal of this project is to obtain advanced training in the treatmetn of chronic pain and opioid dependence in order to conduct treatment-related research on co-occurring chronic pain and opioid dependence. The primary research objective is to develop an integrated psychosocial treatmetn for co-occurring chronic pain and opioid dependence based on formative research conducted during the award period.
Project #: 1R01MH080127-01 Funding Agency: NIMH Title: Gene-Environment Interactions and Risk of Depression in Youth with Diabetes (PI: Delgado, Pedro) Status: Not Funded Period: 10/2007 - 09/2012 Role: Co-Investigator % Effort: Total Costs: $2,535,090.00 Grant Detail: The major goals of this project are to examine how genetic factors, environmental stressors and brain development interact to determine the onset of mood disorders. Project #: W81XWH-07-0717 Funding Agency: Dept of the Army Title: A Civilian/Military Trauma Institute: Resuscitation-Monitoring-Metabolic Control Status: Complete Period: 09/2007 - 09/2013 Role: Co-Investigator % Effort: Total Costs: $5,275,068.00 Grant Detail: Establish procedures to identify upon admission to the emergency department those patients who may require a blood transusion. These procedures will be uniformly implemented at all three Level 1 trauma centers, UTHSCSA, BAMC AND WHMC. The measures to be employed to asses coagulation status of patients with traumatic injuries upon admission will include point of care assessment of aactivated clotting time (ACT) and INR, and laboratory thrombelastography (TEG). The purpose of this effort is to improve patient care and reduce resource utilization. A Department of Defense grant supporting a wide variety of research projects directed towards resuscitation, metabolic control and physiologic monitoring during critical illness. Project #: DAMD17-03-C-0071 Funding Agency: Dept. of the Army Title: Feasibility Study and Demonstration Project for a Joint Military/Civilian Trauma Institute with a Burn Center Status: Complete Period: 09/2005 - 10/2008 Role: Co-Investigator % Effort: 10 Total Costs: $1,847,713.93 Grant Detail: A grant supporting the research, clinical and educational collaboration between UTHSCSA, Brooke Army Medical Center, the U.S. Army Institute for Surgical Research, Wilford Hall Medical Center and University Hospital. Project #: 117549 Funding Agency: NIH/NIAID Title: New Animal Models for Invasive Aspergillosis (N01-AI-30041) Status: Complete Period: 08/2003 - 08/2010
Role: Co-Investigator % Effort: Total Costs: $7,149,604.00 Grant Detail: The overall objective of this proposal is to establish and standardize animal models of invasive aspergillosis that can be used to evaluate genomic information on the pathogenicity and virulence of Aspergillus in order to improve diagnosis and therapy of invasive aspergillosis. We are the lead site for this multi-center collaboration involving sub-contracts at UCLA, MD Anderson, McGill (Montreal, Canada) & Univ of Manchester (UK). Project #: 276700F1 Funding Agency: United States Air Force Title: The Air Force Health Study (PI: Michalek, Joel) Status: Complete Period: 01/1980 - 10/2006 Role: Principal Investigator % Effort: 100 Total Costs: 140,000,000.00 Grant Detail: The purpose of this cohort study was to determine whether adverse health was associated with exposure to Agent Orange in US Air Force veterans of Operation Ranch Hand. Funded under program element 0605306F in the United States Federal Budget. Oversight by the House and Senate Veterans Affairs Committees of the United States Congress and peer-reviewed by the National Academy of Sciences and the US Food and Drug Administration. SERVICE 01/2010-12/2010 Prostate Cancer Peer Review Committee Member Clinical Trial Award/Innovative Treatment Evaluation Award (CTA/ITEA) peer review panel 01/1998-12/1998 A metabolic basis for fibrositis syndrome (FS): Consultant The serotonin deficiency hypothesis. Accepted for presentation at the Nonarticular Rheumatism Study Group (NARSG) meeting during the ARA meeting, Houston, TX 01/1992-12/1992 Early life traumas and confiding in fibromyalgia syndrome(FS) Consultant rheumatoid arthritis (RA), osteoarthritis (OA) and healthy normal controls (NC): Roles of diagnosis, age, sex and ethnic origin. Arthritis and Rheumatism 01/1992-12/1992 Insulin-like growth factor (IGFI) in fibromyalgia (FS) Consultant
Michalek CV (24 August 2016)
Michalek CV (24 August 2016)
Michalek CV (24 August 2016)
Michalek CV (24 August 2016)
Michalek CV (24 August 2016)
Michalek CV (24 August 2016)
Michalek CV (24 August 2016)
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Michalek CV (24 August 2016)

  • 1. CURRICULUM VITAE Joel Edmund Michalek GENERAL INFORMATION PERSONAL DATA: Date of Preparation: 08/22/2016 Address: The University of Texas Health Science Center Department of Epidemiology and Biostatistics, MSC 7933 7703 Floyd Curl Drive, MSN 7933 San Antonio, TX 78229-3900 Phone Number: (210) 567-0886 Fax Number: (210) 567-0921 Email Address: michalekj@uthscsa.edu SELF DESCRIPTION: I have 40 years experience in the analysis and reporting of clinical and epidemiological studies and 30 years experience as a consultant to the pharmaceutical industry, I have published papers in statistical methodology, clinical trials, and epidemiology, and my current interests include methods to analyze survival and count data in cross-over studies. EDUCATION: Year Degree Discipline Institution/Location 1973 PhD Mathematical Statistics Wayne State University, Detroit, MI 1968 MS Mathematics Wayne State University, Detroit, MI 1966 BS Mathematics Wayne State University, Detroit, MI
  • 2. ACADEMIC APPOINTMENTS: 06/2015 - Present Professor UT Health Science Center at San Antonio, Department of Epidemiology and Biostatistics, San Antonio, TX 06/2006 - 06/2015 Professor and Vice Chairman UT Health Science Center at San Antonio, Department of Epidemiology & Biostatistics, San Antonio, TX 05/2005 - 05/2006 Professor and Co- Director UT Health Science Center at San Antonio, Center for Epidemiology and Biostatistics, San Antonio, TX 03/2005 - 05/2005 Clinical Professor UT Health Science Center at San Antonio, Department of Epidemiology and Biostatistics, San Antonio, TX 09/1993 - Present Adjunct Professor The University of Texas at San Antonio, Department of Management Science and Statistics, San Antonio, TX 09/1973 - 06/1976 Assistant Professor Syracuse University, Department of Mathematics, Syracuse, NY Details: I taught undergraduate and graduate courses in mathematical statistics and probability theory. NON-ACADEMIC APPOINTMENTS: 03/1977 - 05/2005 Mathematical Statistician GS-15 Air Force Research Laboratory, Brooks City- Base, TX Details: Directed Energy Bioeffects Division. Principal Investigator, Air Force Health Study (The Ranch Hand Study): 1994 to 2005.
  • 3. 07/1976 - 02/1977 Mathematical Statistician GS-12 Transportation Systems Center, Cambridge, MA HONORS AND AWARDS: 06/2016 Fellow of the American Statistical Association: For contributions to survival analysis and pharmacokinetics, for novel applications of statistics in assessing adverse health effects of dioxin exposure in Vietnam veterans, for consulting service in private industry, and for service to the nation and the profession. 09/1997 CDC and ATSDR Statistical Science Award: Paper Finalist in recognition of "Pharmacokinetics of TCDD in Veterans of Operation Ranch Hand: 10-Year Follow-up." Journal of Toxicology and Environmental Health. 06/1993 CDC & ATSDR Statistics Award: For statistical excellence demonstrated by the publication of "Effects of Measurement Error on Estimating Biological Half-Life." Journal of Exposure Analysis and Environmental Epidemiology 1993; 2:463-476. PROFESSIONAL DEVELOPMENT: Administrative Date Description C.E. Units/Hours 07/21/1997 - 08/01/1997 Science, Technology & Public Policy - U.S. Office of Personnel Management 0.00 / 0.00 11/06/1992 - 11/11/1992 Science, Technology & Public Policy - U.S. Office of Personnel Management 0.00 / 0.00 05/19/1989 - 05/24/1989 Executive Development Seminar - U.S. Office of Personnel Management 0.00 / 0.00 09/24/1982 - 09/28/1982 Personnel Management for Executives, U.S. Department of Defense 0.00 / 0.00 11/11/1981 - 11/14/1981 Theory Z. Institute for Professional Education 0.00 / 0.00 11/30/1978 - 12/02/1978 Laboratory Management of Research & Development, Air Force Institute of Technology 0.00 / 0.00 Other Date Description C.E. Units/Hours 10/30/2000 - 10/31/2000 Preparing and Delivering Congressional Testimony 0.00 / 0.00 Research
  • 4. Date Description C.E. Units/Hours 04/25/2007 CITI Certification 0.00 / 0.00 09/25/2004 Human Participant Protections Education for Research Teams, NCI 0.00 / 0.00 04/17/2003 HIPAA Certification Privacy101: Privacy Awareness 0.00 / 0.00 09/13/1985 - 09/15/1985 Future Uses of Medical Databases 0.00 / 0.00 TEACHING COURSE BASED TEACHING: Date Course Name Level Role 08/2007 - 10/2007 STA 6973 Clinical Trials Undergraduate/Graduate Instructor 3 Credits 08/2006 - 09/2007 MEDI6060 Patient Orient Clin Res Method-2 Undergraduate/Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Patient Oriented Clinical Research Methods 2, Masters of Clinical Investigations 09/2004 - 12/2004 PH 1730 Statistical Methods in Epidemiological Research Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Statistical methods in epidemiology
  • 5. 09/2004 - 12/2004 STA 3513 Probability and Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Probability and statistics 05/2004 - 08/2004 STA 1053 Basic statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Elementary statistics 05/2004 - 08/2004 STA 4133 Introductory Data Analysis with Statistical Software Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Data analysis with statistical software 01/2004 - 05/2004 STA 3513 Probability and Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Probability and statistics 01/2004 - 05/2004 STA 5133 Data Analysis with Statistical Software Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Data analysis with statistical software 09/2003 - 12/2003 STA 5133 Data Analysis with Statistical Software Graduate Sole Teacher
  • 6. Preparation Hrs: 3, Student Contact Hrs: 3 ; Statistical software and applications 05/2003 - 08/2003 STA 3523 Statistical Methods Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 01/2003 - 05/2003 STA 3513 Probability and Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Probability theory and statistics 09/2002 - 12/2002 STA 4953 Special Studies in Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Statistical software and applications 09/2002 - 12/2002 STA 6953 Independent Study Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Statistical software and applications 05/2002 - 08/2002 STA 1053 Basic Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Elementary statistical methods
  • 7. 09/2000 - 12/2000 STA 3513 Probability and Statistics Undergraduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Probability theory and statistics 09/2000 - 12/2000 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; mathematical statistics 09/1999 - 12/1999 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 01/1999 - 05/1999 STA 5073 Methods of Statistics Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1998 - 12/1998 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 4, Student Contact Hrs: 3 ; Mathematical statistics 01/1998 - 05/1998 STA 5073 Methods of Statistics I Graduate Sole Teacher
  • 8. Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1997 - 12/1997 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 01/1997 - 05/1997 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1996 - 12/1996 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 01/1996 - 05/1996 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1995 - 12/1995 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics
  • 9. 09/1995 - 12/1995 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1994 - 12/1994 STA 5083 Methods of Statistics II Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 01/1994 - 05/1994 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics 09/1993 - 12/1993 STA 5073 Methods of Statistics I Graduate Sole Teacher Preparation Hrs: 3, Student Contact Hrs: 3 ; Mathematical statistics RESEARCH EXPERTISE: NIH Study Sections - Clinical Oncology Study Section, 19 May 2008, Bethesda, MD. Signal processing methods in cardiology - A recent study of admittance technology to measure left ventricular volume employed repeated measures statistical modelling and signal processing methods. The results were published in 2015 in Larson, Erik R, Porterfield, John E., Marmol-Velez, Juan, Panday, Manoj, Sagar, Sandeep, Escobedo, Daniel, Michalek JE, Ouyang, Yongjian, Valvano, Jonathan, Pearce,
  • 10. John A, Feldman MD. Admittance to Detect Alterations in Left Ventricular Stroke Volume Heart Rhythm 2014 Nov;11(11):2075-2083. PROJECTS: Clinical Research 03/2012- 09/2012 Prevalence of Demyelinating Polyneuropathy, in Patients with Primary Fibromyalgia Russell IJ, Michalek JE. AxelaCare Health Solutions Inc, Lenexa KS 06/2010- Present A Diagnostic Device for Lung Cancer, Cancer Prevention and Cure, Michigan City, Indiana 02/2000- 11/2000 Antipolymer antibodies in the serum of patients with fibromyalgia syndrome, Autoimmune Technologies, LLC 144 Elks Place, Suite 1402, New Orleans, Louisiana 70112 Clinical Trials 01/2013- 06/2013 A Pivotal, Phase III Trial of Detecting Generalized, Tonic-Clonic Seizures with a Seizure Detection and Warning System in Epilepsy Patients. Brain Sentinel, San Antonio, Texas 12/2012- 06/2014 A randomized phase 2 study of G-pen, A randomized, phase 2, double blind, 3-way crossover study with G-PEN (Glucagon for injection) to evaluate safety, tolerability and comparative pharmacokinetics and pharmacodynamics to Lilly Glucagon in healthy volunteers. Xeris Pharmaceuticals, Austin, Texas 06/2012- Present Diabetic foot ulcer healing, A Prospective, Randomized, Double-Blind Multicenter Study Comparing Continuous Diffusion of Oxygen (CDO) Therapy to standard Moist Wound Therapy (MWT) in the Treatment of Diabetic Foot Ulcers. Electrochemical Oxygen Concepts Inc, San Antonio, Texas 06/2010- 06/2013 A randomized controlled study of bracing in the knee, Outcomes of Bracing in the Treatment of Knee Osteoarthritis. Össur hf. Grjothals 3-5 110 Reykjavik Iceland 09/2009- 12/2009 Investigational Device Exemption - G060062/S007, Investigator's Manual/Protocol Study #CP-PYD-001. Ascension Orthopedics Inc, 8700 Cameron Road, Austin TX 78764 06/2008- 06/2010 Probe-based Confocal Endomicroscopy, Sharma P, Meining Am, Coron E, Lightdale C, Wolfsen H, Bansal A, Bajbouj M, Galmiche JP, Abrams J, Lauwers G, Michalek JE, Wallace M. Detection of neoplastic tissue in Barrett‘s esophagus with in vivo probe-based confocal endomicroscopy (DONT BIOPCE). Final results of a prospective international
  • 11. randomized controlled trial: image guided versus 4 quadrant random biopsies. Mauna Kea Technologies, Paris, France 06/2008- Present Effects of Lyrica, [Pregabaline] on Cerebralspinal Fluid Substance P in Human Subjects with Fibromyalgia Syndrome. Pfizer, New York, New York 01/2007- 12/2007 Phase III laboratory studyof a topical gel formulation, nitroglycerin, MQX-503, in treatment of Raynaud's phenomenon. Clinical study protocol number 03-001. Mediquest Therapeutics, Inc. Seattle, WA 01/2007- 12/2007 Prospective, Randomized, Double-Blind, Multi-Center Trial of Low Dose, Vasopressin versus Placebo in Traumatic Shock Resuscitation 01/2005- 12/2005 A randomized trial of a strategy for increasing high-density lipoprotein, cholesterol levels: effects on progression of coronary heart disease and clinical events. Annals of Internal Medicine 01/2005- 12/2005 Randomized, Double Blind, Placebo-Controlled, Parallel-Group, Multi-Center, Trial Comparing the Effects of Orally Administered Xyrem (sodium oxybate) with Placebo for the Treatment of Fibromyalgia Orphan Medical Inc. Minnetonka MN 01/2004- 12/2004 Determination of the levels of dioxins and dioxin-like compounds, in the Australian population by analysis of pooled human breast milk. Australian Government Department of the Environment and Heritage 01/2002- 12/2002 Alpha-2 adrenergic agonists: evidence and experience examined, Round Table Series 75, The Royal Society of Medicine Press, Ltd 02/2000- 02/2005 Effects of zanaflex® [tizanidine hcl] tablets on, cerebrospinal fluid substance p in human subjects with fibromyalgia syndrome. Elan Pharmaceuticals, Inc. 800 Gateway Boulevard, South San Francisco, CA 94080. 02/2000- 12/2000 Effects on morning stiffness and pain, in the treatment of fibromyalgia syndrome with low dose interferon alpha administered by the oral mucosal route. Veldona USA, Inc., Amarillo, Texas 01/2000- 12/2000 A single-blind, randomized, usual therapy-controlled, double-crossover, study to evaluate the sleep efficacy and safety of the cuddle ewe underquilt in fibromyalgia syntrome. The Cuddle Ewe Company, LLC Maple Grove, MN 05/1999- 07/1999 A double-blind, placebo-controlled study, to evaluate the efficacy and safety of oral glyconutrient supplementation in subjects with fibromyalgia syndrome. 02/1998- 01/1999 A randomized, parallel, placebo-controlled study, of the treatment of Sjogren’s syndrome with low dose interferon alpha administered by the oral mucosal route. Veldona USA, Inc., Amarillo, Texas
  • 12. 01/1998- 12/1998 Treatment of Sjogren‘s syndrome with low dose interferon alpha adminstered, by the oral mucosal route: a randomized, parallel, placebo controlled study. Veldona USA, Inc. Amarillo, TX 02/1993- 02/1994 Treatment of fibromyalgia syndrome with Super Malic, a double-blind placebo controlled crossover pilot study. Optimox Corporation, Torrence, California 11/1991- 04/1992 A Randomized Controlled Clinical Trial to Evaluate the Effect of Intra-Arti, Michalek JE. Pharmacia Orthopedics, Inc. Piscataway, NJ 01/1987- 06/1987 Effects of Ibuprofen and Alprazolam in the Treatment of Fibrositis Syndrome, Russell IJ, Michalek JE, McBroom P, Hester G, Fletcher H, Mauldin M, Miketen S, Tsui-Wu J, Henerson G, Delgado B, Vipraio G, Craighead P. Upjohn, Kalamazoo, MI. Protocol 4105. Collaborative Research 06/2010- 11/2012 Resource Sharing and Cost Recovery Across the CTSA Enterprise, A statistical summary and narrative describing the results of a survey sent to CTSAs. 06/2007- 10/2008 Projecto Bienestar Laredo (PBL), Social Health Research Center, San Antonio, TX 01/2007- 12/2007 Health Canada (CANTOX Environmental). Task 3A-1, Tier 3, Toxicological Risk Assessment Pertaining to Potential Occupational and Related Exposures Associated with Herbicide Spraying Operations at CFB Gagetown 01/2006- 12/2006 Health Canada (CANTOX Environmental) Task 3A-1, Tier 1, Toxicological Risk Assessment Pertaining to Potential Occupational and Related Exposures Associated with Herbicide Spraying Operations at CFB Gagetown-Tier 1-1966-67 U.S. Trials- Manufacturing Impurities (Contaminants). 01/2006- 02/2006 Health Canada (CANTOX Environmental). Task 3A-1, Tier 2, The Toxicological Risk Assessment Pertaining to Potential Occupational and Related Exposures Associated with Herbicide Spraying Operations at Canadian Forces Base (CFB) Gagetown from 1952 to Present 02/2005- 12/2009 Cognitive Assessment, in the fibromyalgia syndrome using a modified trail making test. Russell IJ, Michalek JE. University Clinical Research Center, San Antonio, Texas 02/2005- 02/2005 Hypocretin in Fibromyalgia Syndrome, Russell IJ, Michalek JE. University Clinical Research Center, San Antonio, Texas
  • 13. 01/1993- 12/1993 Biomarkers for Exposure Assesssment, Scientific Workshop on Exposure Assessment, Institute of Medicine, National Academy of Sciences, Washington, DC Departmental Projects 05/1997- 02/2000 Air Force Health Study - Final Report, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. 1997 Follow-up Examination Results. Contract Number: F41624-96-C-1012. 01/1993- 12/1993 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Mortality Update - 1993. Prepared for: The Surgeon General United States Air Force Washington, DC 20314 05/1992- 05/1995 Air Force Health Study - 1992 Follow-up Examination Results, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Contract Number F41624-91-C-1006 01/1992- 01/1994 Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides - Mortality Update 1994. Report Prepared for: The Surgeon General United States Air Force, DC 20332-6188 01/1992- 08/1992 Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Reproductive Outcomes - August 31, 1992. Prepared for: The Surgeon General United States Air Force, Bolling Air Force Base, DC 20332 01/1992- 01/1992 The Air Force Health Study, An epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Reproductive Outcomes. Armstrong Laboratory, Brooks Air Force Base, Texas 1992 02/1991- 02/1991 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Serum Dioxin Analysis of 1987 Follow-up Examination Results. USAF School of Aerospace Medicine, Brooks Air Force Base Texas. (NTIS AD A 237 517 through AD A 237 524), 1991. 01/1991- 12/1991 Air Force Health Study, An Epidemiology Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Mortality Update 1991. Prepared for: The Surgeon General United States Air Force Washington, DC 20314 02/1990- 02/1990 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides, 1987 Follow-up Examination Results. USAF School of Aerospace Medicine.
  • 14. 02/1989- 02/1989 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following exposure to Herbicides: Mortality Update - 1988. USAF School of Aerospace Medicine. 01/1989- 04/1989 Air Force Health Study (Project Ranch Hand II), An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Summary Mortality Update - April 17, 1989. Prepared for: The Surgeon General United States Air Force Bolling AFB, D.C. 20332-6188 02/1987- 02/1987 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. First Follow-up Examination Results. Final Report. USAF School of Aerospace Medicine 01/1986- 12/1986 Air Force Health Study (Project Ranch Hand II), An Epidemiology Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Mortality Update - December 26, 1986. Prepared for: The Surgeon General United States Air Force Washington, D.C 02/1985- 02/1985 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides: Mortality Update - 1985. USAF School of Aerospace Medicine 01/1985- 11/1985 Project Ranch Hand II, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Mortality Update - November 29, 1985. Prepared for: The Surgeon General United States Air Force Washington, D.C. 20314 02/1984- 02/1984 The Air Force Health Study, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides: Mortality Update-1984. USAF School of Aerospace Medicine 01/1984- 12/1984 Project Ranch Hand II - Mortality Update - 1984, An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Prepared for The Surgeon General United States Air Force Washington, D.C. 20314 Exploratory Grant 01/2012- Present Monoclonal gammopathy, Monoclonal gammopathy of uncertain significance and microRNAs in Ranch Hand veterans. Funded by the Institute of Medicine Other
  • 15. 06/2009- 06/2010 A rebuttal for the plaintiff against the defendant, James Carter PC, Peoria Illinois 09/2006- 09/2007 A rebuttal for the defendant against the plaintiff, Fulbright and Jaworski, San Antonio, Texas Research Projects 06/2013- Present Impact of Ticagrelor, Impact of Ticagrelor and Aspirin versus Clopidogrel and Aspirin in Patients with Claudication and Lower Extremity Arterial Disease (LEAD): Thrombus Burden Assessed by Optical Coherence Tomography Funded by AstraZeneca PUBLICATIONS: ('*' indicates Peer Reviewed) Abstract * 1.McHale MJ, Schlechter AK, Torres FM, Michalek JE, McManus LM, Shireman PK. Gender-specific differences in skeletal muscle regeneration, presented at the Academic Surgical Congress, Association for Academic Surgery, 2010 Feb. p. 218. (J Surg Res; vol. 158, no. 2). * 2.McHale M, Schlechter AK, Torres FM, Michalek JE, McManus LM, Shireman PK. Increased fat accumulation in regenerating skeletal muscle in females 2009 Aug. (Annual Meeting of the San Antonio Vascular Surgery Society). * 3.McHale M, Schlechter AK, Torres FM, Michalek JE, McManus LM, Shireman PK. Gender-dependent fat accumulation in regenerating skeletal muscle. 2009 Jan. (Aust Surgical Society). * 4.Martinez CO, Sun D, Waite LL, Michalek JE, McManus LM, Shireman PK. Differential regulation of skeletal muscle regeneration by CCR2-activating chemokines and in vivo characteristics of myogenic progenitor cells 2008 Oct. (Annual Meeting of the San Antonio Vascular Surgery Society). * 5.Ochoa O, Martinez C, Torres FM, Ruiz-Willhite L, Michalek JE, McManus LM, Shireman PK. Differential regulation of skeletal muscle regeneration and angiogenesis by CCR2-activating chemokines, presented at the Academic Surgical Congress, Association for Academic Surgery, 2008 Feb. p. 218-219. (J Surg Res; vol. 144, no. 2).
  • 16. * 6.Sun D, Wetzel MD, Waite LL, Michalek JE, Shireman PK. Environmental factors determine in vivo myogenic progenitor cell function, presented at the Academic Surgical Congress, Society of University Surgeons, 2008 Feb. p. 217-218. (J Surg Res; vol. 144, no. 2). * 7.Sanchez J, Angel LF, Levine DJ, Johnson SB, Michalek JE, Zarzabal LA, Sako E, Pelaez A, Mehta A, Calhoon J, Levine SM, Lyu D. Using Post-Lung Transplant FEV1 To Predict Survival in COPD Patients Undergoing Single Lung Transplantation (SLT) 2007 Oct. p. 596. (CHEST; vol. 132, no. 4). * 8.Shireman PK, Sun D, Ochoa O, Bonilla JR, Waite LL, Michalek JE, McManus LM. Increased myogenic progenitor cell accumulation in CCR2 -/- mice despite bone marrow-dependent impairments in muscle regeneration and macrophage recruitment 2007 Jul. (Skeletal Muscle Satellite & Stem Cells, FASEB Summer Meeting). * 9.Sanchez, JF, Angel LF, Levine DJ, Johnson SB, Calhoon JH, Sako EY, Carpenter AJ, Michalek JE, Levine SM. A Mathematical Model to Predict the Best FEV1 Post Single Lung Transplantation 2007 May. p. A765. (2007 Proceedings of the American Thoracic Society). * 10.Ochoa O, Solomon D, Michalek JE, McManus LM, Shireman PK. Similar capillary density despite decreased vascular endothelial growth factor (VEGF) levels and impaired skeletal muscle regeneration in CC chemokine receptor 2 (CCR2) -/- mice, presented at the Academic Surgical Congress, Society of University Surgeons 2007 Feb. p. 211-212. (J Surg Res; vol. 137, no. 2). * 11.Sanchez J, Angel L, Levine D, Johnson S, Calhoon JH, Sako E, Carpenter A, Michalek JE, Levine SM. A mathematical model to predict the best fev1 post single lung transplantation 2007 Jan. p. A765. (Am J Respir Critical Care Medicine; vol. 175). * 12.Shireman PK, Sun D, Ochoa O, Bonilla JR, Waite LL, Michalek JE, McManus LM. Bone marrow-derived cell regulation of skeletal muscle regeneration. Bandera, TX: 2007. (Proceedings of the International Conference on Age-related Muscle Atrophy: Causes and Mechanisms). * 13.Levine DJ, Angel LF, Coalson JJ, Cline, A, Calhoon JH, Michalek JE, Johnson SB, Sako EY, Carpenter AJ, Levine SM. Histologic Evidence of Pulmonary Arterial Hypertension in Explants of Lung Transplant Recipients With Normal Pre-operative Cardiac Catheterization and Echocardiography 2006. (American Journal of Respiratory and Critical Care Medicine). * 14.Michalek J. Insulin sensitivity following Agent Orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. 2004 Nov. * 15.Pavuk M, Michalek JE and Schecter A. Incidence of prostate cancer in Vietnam US Air Force veterans. 2004 Mar.
  • 17. * 16.Pavuk M, Michalek JE, Jackson Jr W, and Ketchum NS. The metabolic syndrome and cardiovascular mortality in US Air Force veterans of the Vietnam War. 2004. p. 3651- 3656. (Organohalogen Compounds; vol. 66). * 17.Ketchum NS and Michalek JE. Mortality of Air Force veterans exposed to herbicides during the Vietnam War. 2004. p. 3645-3660. (Organohalogen Compounds; vol. 66). * 18.Pavuk M, Michalek J, Ketchum N and Akhtar F. Cancer in US Air Force veterans not involved with spraying herbicides during the Vietnam War. 2004. p. 3639-3644. (Organohalogen Compounds; vol. 66). * 19.Kern P, Said S, Jackson Jr W, Michalek J.. Insulin sensitivity and serum TCDD in Air Force veterans occupationally exposed to herbicides during the Vietnam War. 2004. p. 3166-3173. (Organohalogen Compounds; vol. 66). * 20.Emond C, Michalek JE, Birnbaum LS and DeVito MJ. Use of a PBPK model with dose- dependent elimination rates predicts higher peak dioxin exposures than previously estimated. 2004. p. 2655-2659. (Organohalogen Compounds; vol. 66). * 21.Michalek J. Cancer findings from Air Force veterans who sprayed Agent Orange: Correlation of blood TCDD with cancers. 2003 Nov. * 22.Pavuk M, Schecter A and Michalek J. Correlation of TCDD blood levels with adverse prostate outcome in Air Force veterans who sprayed Agent Orange. 2003 Nov. * 23.Pavuk M, Michalek JE and Schecter A. TCDD and prostate cancer in US Air Force veterans of the Vietnam War. 2003 Sep. * 24.Pavuk M, Schecter A and Michalek JE. Association between diseases of the prostate and TCDD in US Air Force veterans of the Vietnam War. 2003. p. 239-241. (Organohalogen Compounds; vol. 64). * 25.Akhtar F, Garabrant D and Michalek J. Cancer in US Air Force veterans of the Vietnam War. 2003. p. 243-246. (Organohalogen Compounds; vol. 64). * 26.Kern P, Said S, Jackson Jr W and Michalek J. Insulin sensitivity and 2,3,7,8- tetrachlorodibenzo-p-dioxin in US Air Force veterans of the Vietnam War. 2003. p. 182-185. (Organohalogen Compounds; vol. 65). * 27.Dwyer JH, Jackson Jr WH and Michalek JE. Hypertension and 2,3,7,8- tetrachlorodibenzo-p-dioxin. 2002 Nov. * 28.Pavuk M, Schecter A, Akhtar F, Michalek J. Thyroid changes in relation to TCDD in Ranch Hand veterans of the US Air Force. 2002 Nov.
  • 18. * 29.Russell IJ, Michalek JE, Xiao YM, Haynes W and Lawrence RA. Like morning stiffness in rheumatoid arthritis, morning stiffness in fibromyalgia is related to serum hyaluronic acid. 2002 Oct. (American College of Rhematology). * 30.Russell IJ, Michalek JE, Xiao YM, Haynes W, Vertiz R and Lawrence RA. Therapy with a central alpha-2-adrenergic agonist [tizanidine] decreases cerebrospinal fluid substance P, and may reduce serum hyaluronic acid as it improves the clinical symptoms of the fibromyalgia syndrome. 2002 Oct. (American College of Rheumatology). * 31.Wilson RB, Xiao YM, Michalek JE and Russell IJ. Correlation of Anti-Polymer Antibodies with Clinical Measures in Fibromyalgia Syndrome. 2002 Oct. (American College of Rheumatology). * 32.Dwyer JH, Jackson Jr W, Michalek JE. Hypertension and serum 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and hypertension in the Air Force veterans of the Vietnam War. 2002. p. 331-334. (Organohalogen Compounds; vol. 59). * 33.Pavuk M, Schecter AJ, Akhtar FZ, Michalek JE. Effects of TCDD on thyroid metabolism in US Air Force herbicide sprayers. 2002. p. 347-350. (Organohalogen Compounds; vol. 59). * 34.Michalek J, Pirkle JL, Needham LL, Patterson Jr DG and Caudill SP. Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of Operation Ranch Hand. 2001 Nov. * 35.Russell IJ, Michalek JE, Haynes WL and Vertiz R. A single blind, randomized, three period, three treatments, crossover study to evaluate the sleep efficacy of the cuddle ewe under quilt™ for treatment of fibromyalgia. 2001 Feb. (J Musculoske Pain; vol. 9, no. Suppl). * 36.Michalek JE, Akhtar FZ, Ketchum NS and Jackson Jr WG. The Air Force Health Study: A summary of results. 2001. p. 396-399. (Organohalogen Compounds; vol. 54). * 37.Barrett DH, Morris RD, Akhtar FZ and Michalek JE. Serum TCDD and cognitive functioning in Veterans of Operation Ranch Hand. 2001. p. 145-148. (Organohalogen Compounds; vol. 53). * 38.Michalek JE, Ketchum NS and Longnecker MP. Serum TCDD and hepatic abnormalities in Veterans of Operation Ranch Hand. 2001. p. 159-162. (Organohalogen Compounds; vol. 53). * 39.Michalek JE, Akhtar FZ, Longnecker MP, Burton JE. Serum TCDD and hematological examination results in Veterans of Operation Ranch Hand. 2001. p. 172-175. (Organohalogen Compounds; vol. 53).
  • 19. * 40.Barrett DH, Morris RD, Jackson Jr WG and Michalek JE. Serum TCDD and psychological functioning in Veterans of Operation Ranch Hand. 2001. p. 176-179. (Organohalogen Compounds; vol. 53). * 41.Michalek JE, Pirkle JL, Needham LL, Patterson DG, Caudill SP, Tripathi RC, Mocarelli P. Pharmacokinetics of 2,3,7,8-Tetrachlorodibenzo-P-dioxin in Seveso adults and Veterans of Operation Ranch Hand. 2001. p. 340-344. (Organohalogen Compounds; vol. 52). * 42.Xiao Y-M, Russell IJ, Michalek JE and Wilson RB. Anti-polymer antibodies in the serum of patients with fibromyalgia syndrome. 2001. (J Musculoske Pain; vol. 6, no. S5). * 43.Michalek J, Longnecker MP and Akhtar FZ. Dioxin and hematological function in veterans of Operation Ranch Hand. 2000 Nov. * 44.Michalek JE and Ketchum N. Serum dioxin and cancer in veterans of Operation Ranch Hand. 2000. p. 99-102. (Organohalogen Compounds; vol. 48). * 45.Akhtar FZ and Michalek JE. Serum dioxin and peripheral neuropathy in veterans of Operation Ranch Hand. 2000. p. 179-182. (Organohalogen Compounds; vol. 48). * 46.Jackson Jr WG and Michalek JE. Herbicide exposure and heart disease in veterans of operation Ranch Hand. 2000. p. 183-186. (Organohalogen Compounds; vol. 48). * 47.Ketchum N and Michalek JE. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. 2000. p. 256-259. (Organohalogen Compounds; vol. 48). * 48.Ketchum NS, Michalek JE and Burton JE. Serum dioxin and cancer in veterans of operation Ranch Hand. 1999. p. 363-366. (Organohalogen Compounds; vol. 44). * 49.Longnecker MP and Michalek JE. Serum dioxin level in relation to diabetes mellitus and glucose intolerance among Air Force veterans with background levels of exposure. 1999. p. 401-404. (Organohalogen Compounds; vol. 44). * 50.Michalek JE and Boyle CA. Paternal serum dioxin, preterm birth, intrauterine growth retardation and infant death. 1998. p. 223-226. (Organohalogen Compounds; vol. 38). * 51.Michalek JE, Ketchum NS and Akhtar FZ. Post-service mortality of Air Force veterans occupationally exposed to herbicides in Vietnam: 15 Year Follow-up. 1998. p. 235-238. * 52.Michalek JE and Ketchum NS. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. 1997. p. 479-484. (Organohalogen Compounds; vol. 34).
  • 20. * 53.Russell IJ, Michalek JE and Vipraio GA. Serotonin (5HT) in serum and platelets (PLT) from fibromyalgia patients (FM) and normal controls (NC). 1995 Jul. (Third World Congress on Myofascial Pain and Fibromyalgia (abst)). * 54.Russell IJ, Vodjani A, Michalek JE, Vipraio GA, Lopez Y and MacKillip F. Circulating antibodies to serotonin (ASA) in fibromyalgia syndrome (FS) rheumatoid arthritis (RA) osteoarthrosis (OA) and healthy normal controls (NC). 1995 Jul. (Third World Congress on Myofascial Pain and Fibromyalgia). * 55.Michalek J, Russell I, Vipraio GA. Serotonin (5HT) in serum and platelets (PLT) from fibromyalgia patients (FM) and normal controls (NC). 1995. p. 144-144. (J Musculoske Pain; vol. 3, no. S1). * 56.Russell IJ, Orr MD, Michalek JE, Nyberg F, Eriksson U. Substance P (SP), SP endopeptidase activity (SPE), and SP N-terminal peptide (SP1-7) in fibromyalgia syndrome cerebrospinal fluid (CSF). 1995. p. 5-5. (J Musculoske Pain; vol. 3, no. S1). * 57.Russell IJ, Orr MD, Vipraio GA, Alboukrek D, Michalek JE and Lopez YM. Cerebrospinal fluid (CSF) substance P (SP) is elevated in fibromyalgia syndrome (FS). 1993. (Arthritis and Rheumatism; vol. 36, no. S223). * 58.Russell IJ, Vipraio GA, Michalek JE and Lopez YG. Insulin-like growth factor (IGF1) in fibromyalgia (FS), rheumatoid arthritis (RA), osteoarthritis (OA) and healthy normal controls (NC): Roles of diagnosis, age, sex and ethnic origin. 1992. (Arthritis Rheum; vol. 35, no. S160). * 59.Russell IJ, Michalek JE, Vipraio GA, Lawrence VA, Lessard JA and Briggs BT. Automated reading of joint space on osteoarthritis X-rays: Correlation with clinical manifestations. 1992. (Arthritis Rheum; vol. 35, no. S133). * 60.Russell IJ, Michalek JE, Lawrence VA, Lessard JA, Briggs BT and May GS. A randomized, placebo (PL) and no-intervention (NI) controlled, trial of intra-articular (IA) 1% sodium hyaluronate (HA) in the treatment of knee osteoarthritis. 1992. (Arthritis Rheum; vol. 35, no. S132). * 61.Russell IJ, Russell SJ, Cuevas RE and Michalek JE. Early life traumas and confiding in fibromyalgia syndrome (FS). 1992. (Scand J Rheumatol; vol. 94, no. S14). * 62.Russell IJ, Michalek JE, Vipraio GA, Fletcher EM and Wall K. Serum amino acids in fibrositis/fibromyalgia syndrome. 1989. (Arthritis Rheum; vol. 32, no. S70). * 63.Russell IJ, Fletcher EM, Tsui J and Michalek JE. Comparisons of rheumatoid arthritis and fibrositis/fibromyalgia syndrome using functional and psychological outcome measures. 1989. (Arthritis Rheum; vol. 32, no. S70).
  • 21. * 64.Russell IJ, Fletcher EM, Michalek JE, McBroom PC and Hester GG. Efficacy and safety of ibuprofen and alprazolam in the treatment of primary fibrositis/fibromyalgia syndrome. 1989. (Arthritis Rheum; vol. 32, no. S69). * 65.Russell IJ, Bowden CL, Michalek JE, Fletcher EM and Vipraio GA. A metabolic basis for fibrositis syndrome (FS): The serotonin deficiency hypothesis. 1988 May. (ARA Meeting). * 66.Russell IJ, Vipraio GA, Michalek J and Fletcher E. Abnormal T cell subpopulations in fibrositis syndrome. 1988. (Arthritis Rheum; vol. S99). * 67.Russell IJ, Vipraio GA, Tovar Z, Michalek J, and Fletcher E. Abnormal natural killer cell activity in fibrositis syndrome is responsive in vitro to IL-2. 1988. (Arthritis Rheum; vol. S24). * 68.Russell IJ, Bowden CL, Michalek J, Fletcher E and Hester GA. Imipramine receptor density on platelets of patients with fibrositis syndrome: Correlation with disease severity and response to therapy. 1987 Apr. p. 563. (Arthritis Rheum; vol. 30, no. S4). Book Chapter 1.Michalek JE, Cornell JE, Pollock BH. Understanding the Elements that Comprise Evidence-Based Medicine In: Elective General Surgery: An Evidence-Based Approach. Shelton, CT: PMPH-USA Ltd.; 2011. 2.Xiao YM, Michalek JE and Russell IJ. Effects of tizanidine on cerebrospinal fluid substance P in patients with fibromyalgia In: Round Table Series-75. Worcester, UK: The Royal Society of Medicine Press, The Trinity Press; 2001. p. 23 - 28. Journal Article * 1.Simpson, CB, Lee CT, Hatcher JL, Michalek JE. Botulinum toxin treatment of false vocal folds in adductor spasmodic dysphonia: functional outcomes Laryngoscope 2016;126:118-121. * 2.Ha CS, Michalek JE, Elledge R, Kelley KR, Ganapathy S, Su H, Jenkins CA, Agiris A, Swords R, Eng TY, Karnad A, Crownover RL, Swanson GP, Goros M, Pollock BH, Yuan Z. p53-based strategy to reduce hematological toxicity of chemotherapy: A proof of principle study Molecular Oncology 2015 Oct;XXX(YYY)
  • 22. * 3.Landgren, O, Shim, Y, Michalek JE, Costello, R, Burton, D, Ketchum, N, Calvo, K, Caporaso, N, Raveche, E, Middleton, D, Marti, G, Vogt, R. Agent Orange Exposure and Monoclonal Gammopathy of Undetermined Significance. An Operation Ranch Hand Veteran Cohort Study JAMA Oncology 2015 Sep:E1-E8. * 4.Strandberg G, Larsson A, Lipcsey M, Michalek JE, Eriksson M. Intraosseous and intravenous administration of antibiotics yields comparable plasma concentrations during experimental septic shock Acta Anaesthesiol Scan 2015 Jan * 5.Bartanusz Viktor, Jezova Daniela, Sordo Salvador, Gildea Marianne, Michalek JE, Stewart Ronald M, Corneille Michael G.. Diurnal Salivary Cortisol Levels in Acute Trauma Patients at the Surgical-Neurosurgical Intensive Care Unit J Clin Neurosci 2014 Dec;21(12):2150-2154. * 6.Larson, Erik R, Porterfield, John E., Marmol-Velez, Juan, Panday, Manoj, Sagar, Sandeep, Escobedo, Daniel, Michalek JE, Ouyang, Yongjian, Valvano, Jonathan, Pearce, John A, Feldman MD. Admittance to Detect Alterations in Left Ventricular Stroke Volume Heart Rhythm 2014 Nov;11(11):2075-2083. * 7.Shi Q, Hodara V, Meng Q, Voruganti VS, Rice K, Michalek JE, Carmuzzie AG, VandeBerg JL. Early endothelial damage detected by circulating particles in baboons fed a diet high in simple carbohydrates in conjunction with saturated or unsaturated fat Am J Cardiovasc Dis 2014 Oct;4(3):123-132. * 8.Abraham J, Nunez-Alvarez Y, Hettmer S, Carrio E, Chen HI, Nishijo K, Huang ET, Prapjapati SI, Walker RL, Davis S, Rebeles J, Wiebush H, McCleish AT, Hampton ST, Bjornson CR, Brack AS, Wagers AJ, Rando TA, Capecchi MR, Marini FC, Ehler BR, Zarzabal LA, Goros MW, Michalek JE, Meltzer PS, Langenau DM, LeGallo RD, Mansool A, Chen Y, Suelves M, Rubin BP, Keller C. Lineage of origin in rhabdomyscarcoma informs pharmacological response Genes Dev 2014 Jul;25(14):1578-1591. * 9.Kilpadi KL, ElDabaje R, Schmitz JE, Ehler B, Thames TA, Joshi AP, Simmons JW, Michalek JE, Fajardo RJ. Type 2 diabetes is associated with vertebral fractures in a sample of clinic- and hospital-based latinos. J Immigr Minor Health 2014 Jun;16(3):440-449. * 10.Mahalingam D, Malik L, Beeram M, Rodon J, Sankhala K, Mita AC, Benjamin D, Ketchum N, Michalek JE, Tolcher A, Wright J, Sarantopoulos J. Phase II Study Evaluating the Effcacy, Safety, and Pharmacodynamic Correlative Study of Dual Antiangiogenic Inhibition Using Bevaciumab in Combination with Sorafenib in Patients with Advanced Malignant Melanoma Cancer Chemother Pharmacol 2014 May * 11.Cohn SM, DeRosa M, Kumar A, Harrison C, Dent DL, Sivam S, McCarthy MJ, Warner SC, Williams S, Michalek JE, Spinella P. Impact of the Age of Transfused Red Blood Cells in the Trauma Population: A Feasibility Study Injury 2014 Mar;45(3):605-611.
  • 23. * 12.Kikuchi, Hettmer S, Aslam MI, Michalek JE, Laub W, Wilky BA, Loeb DM, Rubin BP, Wagers AJ, Keller C. Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma PLos Genet 2014 Jan;10(1) * 13.Rowe J, Patel S, Mazo-Canola M, Parra A, Goros M, Michalek JE, Kelly KR, Weitman SD, Karnad AB. An Evaluation of Elderly Patients (> 70 years old) Enrolled in Phase I clinical trials at University of Texas Health Science Center at San Antonio Cancer Therapy Research Center from 2009-2011 J Geriatr Oncol 2014 Jan;5(1):65-70. * 14.Hummers LK, Dugowson CE, Dechow FJ, Wise RA, Gregory J, Michalek JE, Yenokyan G, McGready J, Wigley FM. A Multi-Centre, Blinded, Randomsied, Placebo- Controlled, Laboratory-Based Study of MQX-503, a Novel Topical Gel Formulation of Nitroglycerine in Patients with Raynaud Phenomenon Ann Rheum Dis 2013 Dec;72(12):1962-1967. * 15.Kikuchi k, Taniguchi E, Chen HI, Svalina MN, Abraham J, Huang ET, Nishijo K, Davis S, Louden C, Zarzabal LA, Recht O, Bajwa A, Berlow N, Suelves M, Perkins SL, Meltzer PS, Mansoor A, Michalek JE, Chen Y, Rubin BP, Keller C. RB1 Loss Modifies but does not Initiate Alveolar Rhabdomyosarcoma Skelet Muscles 2013 Nov;3(1) * 16.Aslam MI, Hettmer S, Abraham J, Latocha D, Soundararajan A, Huang ET, Goros MW, Michalek JE, Wang S, Mansoor A, Druker BJ, Wagers AJ, Tyner JW, Keller C. Dynamic and Nuclear Expression of PDGFRa and IGF-1R in Alveolar Rhabdomyosarcoma Mol Cancer Res. 2013 Nov;11(11):1303-1313. * 17.Cohn SM, DeRosa M, McCarthy J, Song J, White C, Louden C, Ehler B, Michalek JE, Landry DW. Characterizing Vasopressin and other Vasoactive Mediators Released During Resuscitation of Truama Patients J Trauma Acute Care Surg 2013 Oct;75(4):620-628. * 18.Xiao Y, Haynes W, Russell IJ, Michalek JE. Elevated serum high-sensitivity c-reactive protein levels in fibromyalgia syndrome patients correlate with body mass index, interleukin-6, interleukin-8, erythrocyte sedimentation rate Rheumatol Int 2013 May;33(5):1259-1264. * 19.Schwartz JA, Olarte KT, Michalek JL, Jandu GS, Michel SL, Bruno VM, Michalek JE. Regulation of copper toxicity by Candida albicans GPA2. Eukaryot Cell 2013 Apr * 20.Thompson PM, Bernardo CG, Cruz D, Ketchum N, Michalek JE. Transl Psychiatry Transl Psychiatry 2013 Jan;3:214-214. * 21.Kikuchi K, Soundararajan A, Zarzabal LA, Weems CR, Nelon LD, Hampton ST, Michalek JE, Rubin BP, Fields AP, Keller C. Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma Oncogene 2013 Jan;32(3):286-295.
  • 24. * 22.Garcia-Dominic O, Trevino RP, Echon RM, Mobley C, Block T, Bizzari A, Michalek JE. Improving Quality of Food Frequency Questionnaire Response in Low-Income Mexican American Children Health Promot Pract 2012 Nov;13(6):763-771. * 23.Soundararajan A, Abraham J, Nelon LD, Prajapati SI, Zarzabal LA, Michalek JE, McHardy SF, Hawkins DS, Malempati S, Keller C. 18F-FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically engineered rhabdomyosarcoma models Pediatr Blood Cancer 2012 Sep;59(3):485-492. * 24.Husain SA, Maldonado E, Rasch D, Michalek JE, Taylor R, Curzon C, Neish S, Calhoon JH. Total anomalous pulmonary venous connection: factors associated with mortality and recurrent pulmonary venous obstruction Ann Thorac Surg 2012 Sep;94(3):825-831. * 25.Cornejo A, Sahar DE, Stephenson SM, Chang S, Nguyen S, Guda T, Wenke JC, Vasquez, A, Michalek JE, Sharma R, Krishnegowda NK, Wang HT. Effect of Adipose Tissue-Derived Osteogenic and Endothelial Cells on Bone Allograft Osteogenesis and Vascularization in Critical-Sized Calvarial Defects. Tissue Eng Part A 2012 May;18(15- 16):1-10. * 26.McHale MJ, Sarwar ZU, Cardenas DP, Porter L, Salinas AS, Michalek JE, McManus LM, Shireman PK. Increased fat deposition in injured skeletal muscle is regulated by sex-specific hormones. PMCID: PMC3289262 Am J Physiol Regul Integr Comp Physiol 2012 Jan;302:R331-339. * 27.Abraham J, Chua YX, Glover JM, Tyner JW, Loriaux MM, Kilcoyne A, Giles FJ, Nelon LD, Carew JS, Ouyang Y, Michalek JE, Pal R, Druker BJ, Rubin BP, Keller C. An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma Biochem Biophys Res Commun 2012;426:363-368. * 28.Izbicka E, Streeper RT, Michalek JE, Louden CL, Diaz A, Campos DR. Plasma biomarkers distinguish non-small cell lung cancer from asthma and differ in men and women. Cancer Genomics Proteomics 2012 Jan;9(1):27-35. * 29.Salhanick M, Higgins RA, Olson JD, Michalek JE, Harrison CR, Corneille MG, Stewart RM, Harrison C,Dent DL,. Autotransfusion of Hemothorax Blood In Trauma Patients: Is It the Same as Fresh Whole Blood? Am J Surg 2011 Dec;202(6):817-822. * 30.Meining A, Chen YK, Pleskow D, Stevens P, Shah RJ, Chuttani R, Michalek J, Slivka A. Direct visualization of indeterminate pancreaticobiliary strictures with probe-based confocal laser endomicroscopy: a multicenter experience Gastrointest Endosc 2011 Nov;74(5):961-968. * 31.Cornejo A, Rodriguez T, Steigelman M, Stephenson S, Sahar D, Cohn SM, Michalek JE, Wang HT. The use of visible light spectroscopy to measure tissue oxygenation in free flap reconstruction. Journal of Reconstructive Microsurgery 2011 Sep;27(7):397- 402.
  • 25. * 32.Sharma P, Meining AR, Coron E, Lightdale CJ, Wolfsen HC, Bansal A, Bajbouj M, Galmiche JP, Abrams JA, Rastogi A, Gupta N, Michalek JE, Lauwers GY, Wallace MB. Real-time increased detection of neoplastic tissue in Barrett‘s esophagus with probe-based confocal laser endomicroscopy: final results of an international multicenter, prospective, randomized, controlled trial Gastrointest Endosc 2011 Sep;74(3):465-472. * 33.Sambasivan, CH, Kunio, NR, Nair, PV, Zink, KA, Michalek JE, Holcomb, JB, Schreiber, MA, Trauma Outcomes Group, Wade CE, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Hess JR, Duchesne JC, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudsen P, DeMoya MA, Tieu B, Brundage S, Napolitano LM, Brunsvold M, Sihler KC, Bielman G, Peitzman AB, Zenalt MS, Sperry J, Alarcon L, Croce MA, Minei JP, Kozar R, Gonzales EA, Stewart RM, Cohn SM, Bulgar EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Propper GJ, Marin B. High Ratios of Plasma and Platelets to Packed Red Blood Cells Do Not Affect Mortality in Nonmassively Transfused Patients Journal of Trauma 2011 Aug;71(2):S329-S336. * 34.Li X, Villard JW, Ouyang Y, Michalek JE, Jabara R, Sims D, Kemp N, Glynn T, Banas C, Bailey SR, Feldman MD. Safety and efficacy of frequency domain optical coherence tomography in pigs. EuroIntervention 2011 Aug;7(4):497-504. * 35.Holcomb JB, Zarzabal LA, Michalek JE, ozar RA, Spinella PC, Perkins JG, Matijevic N, Dong JF, Pati S, Wade CE, Trauma Outcomes Group, Holcomb JB, Wade CE, Cotton BA, Kozar RA, Brasel KJ, Vercruysse GA, MacLeod JB, Dutton RP, Hess, JR, Duchesne JC, McSwain NE, Muskat PC, Johannigamn JA, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, DeMoya MA, Schreiber MA, Tieu BH, Brundage SL, Napolitano LM, Brunsvold ME, Sihler KC, Beilman GJ, Peitzman, AB, Zenati, MS, Sperry JL, Alarcon LH, Croce MA, Minei JP, Steward RM, Cohn SM, Michalek JE, Bulger EM, Nunez TC, Ivatury RR, Meredith JW, Miller PR, Propper GJ, Marin B. Increased Platelet:RBC ratios are associated withimproved survival after massive transfusion J Trauma 2011 Aug;71(2s3):s318-s328. * 36.Spoerke N, Michalek JE, Schreiner JM, Trauma Outcomes Group, Brasel KJ, Vercruysse G, MacLeod J, Dutton RP, Duchesne JC, McSwain NE, Muskat P, Johannigamn J, Cryer HM, Tillou A, Cohen MJ, Pittet JF, Knudson P, De Moya MA, Tieu B, Brudage S, Napolitano LM, Brunsvold MA, Sihler KC, Peitzman AB, Zenait MX, Sperry J, Alarcon L, Croce MA, Minei JP, Stewart RM, Cohn SM, Buger EM, Cotton BA, Nunez TC, Ivatury R, Meredith JW, Miller P, Propper GJ. Crystalloid resuscitation improves survival in trauma patient receiving low ratios of fresh frozen plasma to packed red blood cells J Trauma 2011 Aug;71(2S3):S380-S383. * 37.Corneille MG, Nicholsen, S, Richa, J, Son, C, Michalek JE, Wolf SE, Stewart RM. Liver Dysfunction by Model for End-Stage Liver Disease Score Improves Mortality Prediction in Injured With Cirrhosis The Journal of Trauma 2011 Jul;71(1)
  • 26. * 38.McNeil JD, Brandon Propper, Joshua Walker, Lauren Holguin, Lauren Evans, Kihak Lee, Fox PT, Michalek JE, Baisden CE. A bovine hemoglobin-based oxygen carrier as pump prime for cardiopulmonary bypass: reduced systemic lactic acidosis and improved cerebral oxygen metabolism during low-flow in a porcine model Journal of Thoracic and Cardiovascular Surgery 2011 Jun;142(2):411-417. * 39.Prajapati SI, Kilcoyne A, Samano AK, Green DP, McCarthy SC, Blackman BA, Brady MM, Zarzabal LA, Tatiparthy AK, Sledz TJ, Duong T, Ohshima-Hosoyama S, Giles FJ, Michalek JE, Rubin BP, Keller C. MicroCT-based virtual histology evaluation of preclinical medulloblastoma Mol Imaging Biol 2011 Jun;13(3):493-499. * 40.Streeper RT, Diaz A, Campos D, Michalek JE, Louden C, Furmaga W, Izbicka E. Syntra-5 Downregulates Inflammatory In Obese Type 2 Diabetes Murine Model In Vivo. Curr Top Nutraceutical Res 2011 May;9(1/2):1-12. * 41.Hosoyama T, Aslam MI, Abraham J, Prajapati SI, Nishijo K, Michalek JE, Zarzabal LA, Nelon LD, Guttridge DC, Rubin BP, Keller C. IL-4R drives dedifferentiation, mitogenesis in rhabdomyosarcoma Clin Cancer 2011 May;17(9):2757-2766. * 42.Swanson GP, Du F, Michalek JE, Hermans M. Long-term follow-up and risk of cancer death after radiation for post-prostatectomy rishing prostate-specific antigen Int J Radiat Oncol Biol Phys 2011 May;80(1):62-68. * 43.Abraham J, Nelon LD, Kubicek CB, Kilcoyne A, Hampton ST, Zarzabal LA, Giles FJ, Michalek JE, Rubin BP, Keller C. Preclinical testing of erlotinib in a transgenic alveolar rhabdomyosarcoma mouse model. Sarcoma 2011 Apr;2011:130484-130484. * 44.Michalek JE, Preuss HG, Croft HA, Keith PL, Keith SC, Dapilmoto M, Perricone NV, Leckie RB, Kaats GR. Changes in total body bone mineral density following a common bone health plan with two versions of a unique bone health supplement: a comparative effectiveness research study Nutr J 2011 Apr;10(32) * 45.Bini JK, Cohn SM, Acosta SM, McFarland MJ, Muir MT, Michalek JE. Mortality, Mauling, and Maiming by Vicious Dogs Ann Surg 2011 Apr;253(4):791-797. * 46.Mueller DL, Hatab M, Al-Senan R, Cohn SM, Corneille MG, Dent DL, Michalek JE, Myers JG, Wolf SE, Stewart RM. Pediatric Radiation Exposure During the Initial Evaluation for Blunt Trauma J Trauma 2011 Mar;70(3):724-731. * 47.Woodward CS, Son MG, Calhoon JH, Michalek JE, Husain SA. Sternal Wound Infections in Pediatric Congential Cardiac Surgery: A Survey of Incidence and Preventative Practice Ann Thorac Surg 2011 Mar;91(3):799-804. * 48.Cohn SM, McCarthy J, Stewart RM, Jonas RB, Dent DL, Michalek JE, UTHSCSA Clinical Trials Group (Mueller D, member of the investigative group). Impact of Low- dose Vasopressin on Trauma Outcome: Prospective Randomized Study. World J Surg 2011 Feb;35(2):430-439.
  • 27. * 49.Rubin BP, Nishijo K, Chen HI, Yi X, Schuetze DP, Pal R, Prajapati SI, Abraham J, Arenkiel BR, Chen QR, Davis S, McCleish AT, Capecchi MR, Michalek JE, Zarzabal, LA, Khan J, Yu Z, Parham DM, Barr FG, Meltzer PS, Chen Y, Keller C. Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma Cancer Cell 2011 Feb;19(2):177-191. * 50.Holcomb JB, Weiskopf R, Champion H, Gould SA, Sauer RM, Brasel K, Bochicchio G, Cotton BA, Davis D, Dutton R, Hauser CJ, Hess JR, Hides GA, Knudson P, MacKenzie E, McGinnis RL, Michalek JE, Moore FA, Omert L, Pollock BH, Tortella B, Sugarman J, Schreiber MA, Wade CE. Challenges to effective research in acute trauma resuscitation: consent and endpoints Shock 2011 Feb;35(2):107-113. * 51.Corneille MG, Villa, C, Wolf SE, Michalek JE, Jung I, Wade CE, Myers JG, Dent DL, Mueller DL, Stewart RM. Time and Degree of Glycemic Derangement Are Associated with Increased Mortality in Trauma Patients in the Setting of Tight Glycemic Control Am J Surg 2010 Dec;200(6):832-837. * 52.Cohn SM, Pearl SM, Nowlin MU, Hernandez A, Guta C, Michalek JE, NIRF Clinical Trials Group. A Prospective Randomized Pilot Study of Near-Infrared Spectroscopy Directed Restricted Fluid Therapy versus Standard Fluid Therapy in Patients undergoing Elective Colorectal Surgery (in press) American Surgery 2010 Dec;76(12):1384-1392. * 53.Martinez CO, McHale MJ, Wells JT, Ochoa O, Michalek JE, McManus LM, Shireman PK. Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment. PMCID: PMC2944434 Am J Physiol Regul Integr Comp Physiol 2010 Sep;299(3):R832-R842. * 54.Prajapati SI, Martinez CO, Abraham J, McCleish AT, Michalek JE, McManus LM, Rubin B, Shireman PK, Keller C. Crimson carrier, a long-acting contrast agent for in vivo near-infrared imaging of injured and diseased muscle. PMCID: PMC2910161 Muscle and Nerve 2010 Aug;42(2):245-251. * 55.Schaffer BS, Grayson MH, Wortham JM, Kubicek CB, McCleish AT, Prajapati SI, Nelon LD, Brady MM, Jung I, Hosoyama T, Sarro LM, Hanes MA, Rubin BP, Michalek JE, Clifford CB, Infante AJ, Keller C. Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice. Mol Cancer Ther 2010 Aug;9(8):2354-2364. * 56.Gifford SM, Aidinian G, Clouse WD, Fox CJ, Porras CA, Jones WT, Zarzabal LA, Michalek JE, Propper BW, Burkhardt GE, Rasmussen TE. Effect of temporary shunting on extremity vascular injury: an outcome analysis from the Global War on Terror vascular injury initiative J Vasc Surg 2009 Sep;50(3):549-555.
  • 28. * 57.Schecter A, Needham L, Pavuk M, Michalek JE, Colacino J, Ryan J, Papke O, Birnbaum L. Agent Orange expoure,Vietnam war veterans, and the risk of prostate cancer Cancer 2009 Jul;115(14):3369-3371. * 58.Stewart RM, Park PK, Hunt JP, McIntyre RC, McCarthy J, Zarzabal LA, Michalek JE. Less is more: improved outcomes in surgical patients with conservative fluid administration and central venous catheter monitoring. Journal of the American College of Surgeons 2009 May;208(5):725-735. * 59.Nishijo K, Chen QR, Zhang L, McCleish AT, Rodriguez A, Cho MJ, Prajapati SI, Gelfond JA, Chisholm GB, Michalek JE, Aronow BJ, Barr FG, Randall RL, Ladanyi M, Qualman SJ, Rubin BP, LeGallo RD, Wang C, Khan J, Keller C. Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. Cancer Res 2009 Apr;69(7):2902-2911. * 60.Sun D, Martinez C, Ochoa O, Ruiz-Willhite L, Bonilla JR, Centonze VE, Waite LL, Michalek JE, McManus LM, Shireman PK. Bone marrow-derived cell regulation of skeletal muscle regeneration. PMCID: PMC2630778 FASEB J 2009 Feb;23(2):382- 395. * 61.Sun D, Martinez CO, Ochoa O, Ruiz-Willhite L, Bonilla JR, Centonze VE, Waite LL, Michalek JE, McManus LM, Shireman PK. Bone marrow-derived cell regulation of skeletal muscle regeneration. FASEB J 2009 Feb;23(2):382-395. * 62.Russell IJ, Perkins AT, Michalek JE. Oxybate SXB-26 FMS Study Group. Sodium Oxybate [Xyrem] Improves Sleep and Relieves Pain in Patients with the Fibromyalgia Syndrome: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Clinical Trial. In submission to Arthritis and Rheumatism 2009 Jan;60(1):299-309. * 63.Cadena J, Levine DJ, Angel LF, Maxwell PR, Brady R, Sanchez JF, Michalek JE, Levine SM, Restrepo MI. Antifungal prophylaxis with voriconazole or itraconazole in lung transplant recipients: hepatotoxicity and effectiveness American Journal of Transplantation 2009;9(9):2085-2091. * 64.Prajapati SI, Martinez CO, Bahadur AN, Wu IQ, Zheng W, Lechleiter JD, McManus LM, Chisholm GB, Michalek JE, Shireman PK, Keller C. Near-infrared imaging of injured tissue in living subjects using IR-820. Mol Imaging 2009 Jan;8(1):45-54. * 65.Bingener J, Krishnegowda NK, Michalek JE. Immunologic parameters during NOTES compared with laparoscopy in a randomized blinded porcine trial Surg Endosc 2009 Jan;23(1):178-181. * 66.Bingener-Casey J, Buck, Lauren A, Schwesinger WH, Van Sickle KR, Michalek JE. Can Gastric Irrigation Prevent Infection During NOTES Mesh Placement? Epub 2008 Aug 13 J Gastrointest Surg 2008 Nov;12(11):2010-2014.
  • 29. * 67.Taniguchi E, Nishijo K, McCleish AT, Michalek JE, Grayson MH, Infante AJ, Abboud HE, Legallo RD, Qualman SJ, Rubin BP, Keller C. PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma. Oncogene 2008 Nov;27(51):6550-6560. * 68.Boyd, T, Jung I, Van Sickle KR, Schwesinger WH, Michalek JE, Bingener-Casey J. Music Experience influences Laparoscopic Skills Performance Journal of the Society of Laparoendoscopic Surgeons 2008 Sep;12(3):292-294. * 69.Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, Williams KL, Park MS. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients Ann Surg 2008 Sep;248(3):447-458. * 70.Bingener J, Michalek J, Van Sickle K, Schwesinger W. Randomized blinded trial shows relative thrombocytopenia in natural orifice translumenal endoscopic surgery compared with standard laparoscopy in a porcine survival model Surg Endosc 2008 Sep;22(9):2067-2071. * 71.Bingener-Casey J, Michalek JE, Winston JH, Van Sickle KR, Haines V, Schwesinger WH, Lawrence VA. Randomized Blinded Trial Comparing the Cardiopulmonary Effects of NOTES with Standard Laparoscopy in a Porcine Survival Model Epub 2008 Apr 9 Surg Endosc 2008 Jun;195(2):1430-1434. * 72.Michalek JE, Pavuk M. Diabetes and Cancer in Veterans of Operation Ranch Hand after adjustment for calendar period, days of spraying, and time spent in Southeast Asia. The Journal of Occupational and Environmental Medicine 2008 Mar;50:330-340. * 73.Bingener J, Michalek JE, Winston J, Van Sickle K, Haines V, Schwesinger W, Lawrence V. Randomized blinded trial comparing the cardiopulmonary effects of NOTES with standard larparoscopy in a porcine survival model Surgical Endoscopy (DOI 10.1007/x00464-008-9898-8) 2008 Feb * 74.Bingener J, Cox D, Michalek JE, Mejia A. Can the MELD score predict perioperative morbidity for patients with liver cirrhosis undergoing laparoscopic cholecystectomy? Am Surg 2008 Feb;74(2):156-159. * 75.Lopez PP, Cohn SM, Popkin CA, Jackowski J, Michalek JE. The use of a computed tomography scan to rule out appendicitis in women of childbearing age is as accurate as clinical examination: a prospective randomized trial. Am Surg 2007 Dec;73(12):1232-1236. * 76.Ochoa O, Sun D, Reyes-Reyna SM, Waite LL, Michalek JE, McManus LM, Shireman PK. Delayed angiogenesis and VEGF production in CCR2-/- mice during impaired skeletal muscle regeneration. PMID: 17522124 Am J Physiol Regul Integr Comp Physiol 2007 Aug;293(2):651-661.
  • 30. * 77.Bingener-Casey J, Buck L, Richards ML, Michalek JE, Schwesinger WH, Sirinek KR. Long-term outcomes in laparoscopic vs. open ventral hernia repair. Arch Surg 2007 Jun;142(6):562-567. * 78.Ochoa O, Sun, D, Reyes-Reyna, SM, Waite, LL, Michalek JE, McManus LM, Shireman PK. Delayed angiogenesis and VEGF production in CCR2 -/- mice during impaired skeletal muscle regeneration. Am J Physiol Reg Int Comp Physiol 2007 May;ePub * 79.Cohn SM, Price MA, Stewart RM, Michalek JE, Dent DL, McFarland MJ, Pruitt BA. A Crisis in the Delivery of Care to Patients with Brain injuries in South Texas. J Trauma 2007 Apr;62(4):951-963. 80.Taiwo OB, Russell IJ, Mignot E, Lin L, Michalek JE, Haynes W, Xiao Y, Zeitzer JM, Larson AA. Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome. Sleep Med 2007 Apr;8(3):260-265. * 81.Shireman PK, Contreras-Shannon V, Ochoa O, Karia BP, Michalek JE, McManus LM. MCP-1 deficiency causes altered inflammation with impaired skeletal muscle regeneration. J Leukoc Biol 2007 Mar;81:775-785. * 82.Contreras-Shannon V, Ochoa O, Reyes-Reyna SM, Sun D, Michalek JE, Kuziel WA, McManus LM, Shireman PK. Fat accumulation with altered inflammation and regeneration in skeletal muscle of CCR2-/- mice following ischemic injury. PMID: 17020936 Am J Physiol Cell Physiol 2007 Feb;292(2):c953-c967. * 83.Ketchum NS, Michalek JE, and Pavuk M. Mortality, length of life, and physical examination attendance in participants of the Air Force Health Study Military Medicine 2007 Jan;172(1):53-57. * 84.Bingerer J, Buck L, Richards M, Michalek JE, Schwesinger W, Sirinek K. Long-term Outcomes in Laparoscopic vs Open Ventral Hernia Repair Archives of Surgery 2007 Jan;142:562-567. * 85.Fujiyoshi P, Michalek JE, and Matsumura F. Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in US Air Force veterans of the Vietnam War Environmental Health Perspectives 2006 Nov;114(11):1-7. * 86.Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans Environmental Health Perspectives 2006 Nov;114(11):1649-1654. * 87.Fujiyoshi PT, Michalek JE, Matsumura F. Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air force veterans of the Vietnam war. Environ Health Perspect 2006 Nov;114(11):1677-1683.
  • 31. * 88.Boyle SH, Michalek JE, Suarez EC. Covariation of psychological attributes and incident coronary heart disease in U.S. Air Force veterans of the Vietnam war. Psychosom Med 2006 Nov;68(6):844-850. * 89.Cohn SM, Price MA, Stewart RM, Michalek JE, Dent DL, Pruitt BA. A crisis in the delivery of care to brain injured patients Proceedings of the Texas Surgical Society 2006 Oct * 90.Kaats GR, Michalek JE, Preuss HG. Evaluating efficacy of a chitosan product using a double-blinded, placebo-controlled protocol Journal of the American College of Nutrition 2006 Oct;25(5):389-394. * 91.Boyle SH, Suarez EC and Michalek JE. Covariation of Psychological Attributes and Incident coronary heart disease. Psychosomatic Medicine 2006;68(6):844-850. * 92.Ketchum NS, Michalek JE. Postservice mortality of Air Force veterans occupationally exposed to herbicides during the Vietnam War: 20-year follow-up results Military Medicine 2005 May;170(5):406-413. * 93.Pavuk M, Michalek JE, Schecter A, Ketchum NS, Akhtar FZ, Fox KA. Did TCDD exposure or service in Southeast Asia increase the risk of cancer in air force Vietnam veterans who did not spray agent orange? J Occup Environ Med 2005 Apr;47(4):335- 342. * 94.Kingman, Albert, Albers, James W, Arezzo, Joseph C, Garabrant, David H, Michalek JE. Amalgam exposure and neurological function Neurotoxicology 2005 Mar;26(2):241-255. * 95.Whitney EJ, Krasuski RA, Personius BE, Michalek JE, Maranian AM, Kolasa MW, Monick E, Brown BG, Gotto AM. A randomized trial of a strategy for increasing high- density lipoprotein cholesterol levels: effects on progression of coronary heart disease and clinical events. Ann Intern Med 2005 Jan;142(2):95-104. * 96.Ketchum NS and Michalek JE. Post-service mortality of Air Force veterans occupationally exposed to herbicides during the Vietnam War. Military Medicine 2005;170(5):406-413. * 97.Emond C, Michalek J, Birnbaum LS, DeVito MJ. Comparison of the use of a physiologically based pharmacokinetic model and a classical pharmacokinetic model for dioxin exposure assessments Environmental Health Perspectives 2005;113(12):1666-1668. * 98.Kingman A, Albers JW, Arezzo JC, Garabrant DH, Michalek JE. Amalgam exposure and neurological function. Neurotoxicology 2005;26(2):241-255. * 99.Pavuk M, Michalek JE, Schecter A, Ketchum NS, Akhtar FZ, Fox KA. Did dioxin or service in Southeast Asia increase the risk of cancer in Air Force Vietnam veterans
  • 32. who did not spray Agent Orange? Journal of Occupational and Environmental Medicine 2005;47(4):335-342. * 100.Kern PA, Said S, Jackson WG, Michalek JE. Insulin sensitivity following agent orange exposure in Vietnam veterans with high blood levels of 2,3,7,8-tetrachlorodibenzo-p- dioxin. J Clin Endocrinol Metab 2004 Sep;89(9):4665-4672. * 101.Akhtar FZ, Garabrant DH, Ketchum NS, Michalek JE. Cancer in US Air Force veterans of the Vietnam War. J Occup Environ Med 2004 Feb;46(2):123-136. * 102.Xiao Y, Russell IJ, Michalek JE, and Lawrence R. Changes in hyaluronate levels correlate with subjective stiffness in fibromyalgia. (In Submission) 2004 Feb * 103.Pavuk M, Schecter AJ, Akhtar FZ, Michalek JE. Serum 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) levels and thyroid function in Air Force veterans of the Vietnam War. Ann Epidemiol 2003 May;13(5):335-343. * 104.Michalek JE, Barrett DH, Morris RD, Jackson WG. Serum dioxin and psychological functioning in U.S. Air Force veterans of the Vietnam War. Mil Med 2003 Feb;168(2):153-159. * 105.Michalek JE, Ketchum NS, Tripathi RC. Diabetes mellitus and 2,3,7,8- tetrachlorodibenzo-p-dioxin elimination in veterans of Operation Ranch Hand. J Toxicol Environ Health A 2003 Feb;66(3):211-221. * 106.Michalek JE, Pirkle JL, Needham LL, Patterson DG, Caudill SP, Tripathi RC, Mocarelli P. Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand. J Expo Anal Environ Epidemiol 2002 Jan;12(1):44- 53. * 107.Steenland K, Calvert G, Ketchum N and Michalek JE. Dioxin and diabetes mellitus: an analysis of the combined NIOSH and Ranch Hand data. Occupational and Environmental Medicine 2001 Oct;58:641-648. * 108.Barrett DH, Morris RD, Akhtar FZ, Michalek JE. Serum dioxin and cognitive functioning among veterans of Operation Ranch Hand. Neurotoxicology 2001 Aug;22(4):491-502. * 109.Michalek JE, Akhtar FZ, Arezzo JC, Garabrant DH, Albers JW. Serum dioxin and peripheral neuropathy in veterans of Operation Ranch Hand. Neurotoxicology 2001 Aug;22(4):479-490. * 110.Michalek JE, Ketchum NS, Longnecker MP. Serum dioxin and hepatic abnormalities in veterans of Operation Ranch Hand. Ann Epidemiol 2001 Jul;11(5):304-311.
  • 33. * 111.Guo X, Longnecker MP, Michalek JE. Relation of serum tetrachlorodibenzo-p-dioxin concentration to diet among veterans in the Air Force Health Study with background- level exposure. J Toxicol Environ Health A 2001 Jun;63(3):159-172. * 112.Jackson WG, Michalek JE. Temporal changes in TCDD levels in 1419 Air Force Vietnam-era veterans not occupationally exposed to herbicides. J Expo Anal Environ Epidemiol 2001;11(1):50-55. * 113.Michalek JE, Akhtar FZ, Longnecker MP, Burton JE. Relation of serum 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) level to hematological examination results in veterans of Operation Ranch Hand. Arch Environ Health 2001;56(5):396-405. * 114.Larson AA, Giovengo SL, Russell IJ, Michalek JE. Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways. Pain 2000 Aug;87(2):201-211. * 115.Longnecker MP, Michalek JE. Serum dioxin level in relation to diabetes mellitus among Air Force veterans with background levels of exposure. Epidemiology 2000 Jan;11(1):44-48. * 116.Selvavel K, Nanthakumar A and Michalek JE. On the estimation of P(X less than Y) for truncated bivariate exponential distribution and its application. Journal of Applied Statistical Science 2000;10:47-56. * 117.Mehrotra KG, Kulkarni PM, Tripathi RC, and Michalek JE. Maximum likelihood estimation for longitudinal data with truncated observations. Statistics in Medicine 2000;19:2975-2988. * 118.Russell IJ, Vipraio GA, Michalek JE, Craig FE, Kang YK, Richards AB. Lymphocyte markers and natural killer cell activity in fibromyalgia syndrome: effects of low-dose, sublingual use of human interferon-alpha. J Interferon Cytokine Res 1999 Aug;19(8):969-978. * 119.Russell IJ, Michalek JE, Kang YK, Richards AB. Reduction of morning stiffness and improvement in physical function in fibromyalgia syndrome patients treated sublingually with low doses of human interferon-alpha. J Interferon Cytokine Res 1999 Aug;19(8):961-968. * 120.Ship JA, Fox PC, Michalek JE, Cummins MJ, Richards AB. Treatment of primary Sjogren's syndrome with low-dose natural human interferon-alpha administered by the oral mucosal route: a phase II clinical trial. IFN Protocol Study Group. J Interferon Cytokine Res 1999 Aug;19(8):943-951. * 121.Longnecker MP and Michalek JE. Weight history, glucose intolerance, and insulin levels in middle-aged Swedish men. Am J Epidemiol 1999 Aug;150(4):430-432.
  • 34. 122.Longnecker MP, Michalek JE. Re: "Weight history, glucose intolerance, and insulin levels in middle-aged Swedish men". Am J Epidemiol 1999 Aug;150(4):430-432. * 123.Michalek JE, Tripathi RC. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 15-year follow-up. J Toxicol Environ Health A 1999 Jul;57(6):369-378. * 124.Michalek JE, Ketchum NS, Check IJ. Serum dioxin and immunologic response in veterans of Operation Ranch Hand. Am J Epidemiol 1999 Jun;149(11):1038-1046. * 125.Michalek JE, Akhtar FZ, Kiel JL. Serum dioxin, insulin, fasting glucose, and sex hormone-binding globulin in veterans of Operation Ranch Hand. J Clin Endocrinol Metab 1999 May;84(5):1540-1543. * 126.Ketchum NS, Michalek JE, Burton JE. Serum dioxin and cancer in veterans of Operation Ranch Hand. Am J Epidemiol 1999 Apr;149(7):630-639. * 127.Michalek JE, Ketchum NS, Akhtar FZ. Postservice mortality of US Air Force veterans occupationally exposed to herbicides in Vietnam: 15-year follow-up. Am J Epidemiol 1998 Oct;148(8):786-792. * 128.Michalek JE, Rahe AJ, Boyle CA. Paternal dioxin and the sex of children fathered by veterans of Operation Ranch Hand. Epidemiology 1998 Jul;9(4):474-475. * 129.Michalek JE, Rahe AJ, Boyle CA. Paternal dioxin, preterm birth, intrauterine growth retardation, and infant death. Epidemiology 1998 Mar;9(2):161-167. * 130.van der Molen GW, Kooijman SA, Michalek JE, Slob W. The estimation of elimination rates of persistent compounds: a re-analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in Vietnam veterans. Chemosphere 1998;37(9-12):1833-1844. * 131.Burton JE, Michalek JE, Rahe AJ. Serum dioxin, chloracne, and acne in veterans of Operation Ranch Hand. Arch Environ Health 1998;53(3):199-204. * 132.Michalek JE, Rahe AJ, Kulkarni PM, Tripathi RC. Levels of 2,3,7,8-tetrachlorodibenzo- p-dioxin in 1,302 unexposed Air Force Vietnam-era veterans. J Expo Anal Environ Epidemiol 1998;8(1):59-64. * 133.Kulkarni PM, Tripathi RC, Michalek JE. Maximum (Max) and Mid-P confidence intervals and p values for the standardized mortality and incidence ratios. Am J Epidemiol 1998 Jan;147(1):83-86. * 134.Michalek JE, Tripathi RC, Kulkarni PM, Gupta PL and Selvavel K. Correction for bias introduced by truncation in pharmacokinetic studies of environmental contaminants. Environmetrics 1998;9:165-174.
  • 35. * 135.Mazur A and Michalek JE. Marriage, divorce, and male testosterone. Social Forces 1998;77:315-330. * 136.Michalek JE. Letter to the editor. Epidemiology 1998;9:359-360. * 137.Schecter AJ, Michalek JE, May J and Papke O. Dioxin and dibenzofuran congeners in 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, and Agent Orange. Organohalogen Compounds 1998;36:285-288. * 138.Michalek JE, Caudill SP, Tripathi RC. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up. Erratum. J Toxicol Environ Health 1997 Dec;52(6):557-558. * 139.Henriksen GL, Ketchum NS, Michalek JE, Swaby JA. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. Epidemiology 1997 May;8(3):252-258. * 140.Henriksen GL, Michalek JE, Swaby JA, Rahe AJ. Serum dioxin, testosterone, and gonadotropins in veterans of Operation Ranch Hand. Epidemiology 1996 Jul;7(4):352- 357. * 141.Michalek JE, Pirkle JL, Caudill SP, Tripathi RC, Patterson DG, Needham LL. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up. J Toxicol Environ Health 1996 Feb;47(3):209-220. * 142.Michalek JE, Tripathi RC, Kulkarni PM, Pirkle JL. The reliability of the serum dioxin measurement in veterans of Operation Ranch Hand. J Expo Anal Environ Epidemiol 1996;6(3):327-338. * 143.Henriksen GL and Michalek JE. Letter to the editor. Epidemiology 1996;7(4):454-455. * 144.Russell IJ, Orr MD, Michalek JE, Nyberg F and Eriksson U. Substance P (SP), SP endopeptidase activity (SPE), and SP N-terminal peptide (SP1-7) in fibromyalgia syndrome cerebrospinal fluid (CSF). Third World Congress on Myofascial Pain and Fibromyalgia (abst) 1995 Jul * 145.Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995 May;22(5):953-958. * 146.Michalek JE, Wolfe WH, Miner JC, Papa TM, Pirkle JL. Indices of TCDD exposure and TCDD body burden in veterans of Operation Ranch Hand. J Expo Anal Environ Epidemiol 1995;5(2):209-223. * 147.Wolfe WH, Michalek JE, Miner JC, Rahe AJ, Moore CA, Needham LL, Patterson DG. Paternal serum dioxin and reproductive outcomes among veterans of Operation Ranch Hand. Epidemiology 1995 Jan;6(1):17-22.
  • 36. * 148.Tiwary CM, Michalek JE. Incidence of diabetes among dependents of the U.S. military forces admitted to U.S. Army treatment facilities, 1971-1991. Diabetes Care 1995 Jan;18(1):90-92. * 149.Wolfe WH, Michalek JE, Miner JC, Pirkle JL, Caudill SP, Patterson DG, Needham LL. Determinants of TCDD half-life in veterans of Operation Ranch Hand. J Toxicol Environ Health 1994 Apr;41(4):481-488. * 150.Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE, Lopez Y and Mackillip F. Elevated cerebral spinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis and Rheumatism 1994;37:1593-1601. * 151.Russell IJ, Michalek JE, Vipraio GA, Fletcher EM, Javors MA and Bowden CA. Reply to letter regarding manuscript entitled: Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome Journal of Rheumatology 1993;20:1986-1988. * 152.Wolfe WH, Miner JC, Michalek JE. Immunological parameters in current and former US Air Force personnel. Vaccine 1993 Jan;11(5):545-547. * 153.Wolfe WH, Miner JC, Michalek JE. Immunological parameters in current and former US Air Force personnel. Vaccine 1992;11(5):545-547. * 154.Michalek JE, Tripathi RC, Caudill SP, Pirkle JL. Investigation of TCDD half-life heterogeneity in veterans of Operation Ranch Hand. J Toxicol Environ Health 1992 Jan;35(1):29-38. * 155.Caudill SP, Pirkle JL, Michalek JE. Effects of measurement error on estimating biological half-life. J Expo Anal Environ Epidemiol 1992;2(4):463-476. * 156.Russell IJ, Michalek JE, Vipraio GA, Fletcher EM, Javors MA, Bowden CA. Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol 1992 Jan;19(1):104-109. * 157.Wolfe WH, Michalek JE, Miner JC, Pirkle J, Caudill S, Needham L and Patterson Jr DG. Dioxin half-life in veterans of Operation Ranch Hand. Organohalogen Compounds 1992;10:239-242. * 158.Wolfe WH, Michalek JE, Miner JC, Needham LL and Patterson Jr, DG. Diabetes versus dioxin body burden in veterans of Operation Ranch Hand. Organohalogen Compounds 1992;10:279-282. * 159.Wolfe WH, Michalek JE, Miner JC, Rahe A, Moore CA, Needham LL and Patterson Jr DG. Reproductive outcomes versus paternal dioxin body burden in veterans of Operation Ranch Hand. Organohalogen Compounds 1992;10:283-286.
  • 37. * 160.Russell IJ, Russell SJ, Cuevas RE, Michalek JE. Early life traumas and confiding in fibromyalgia syndrome (FS). Scandanavian Journal of Rheumatology 1992;94(S14) * 161.Russell IJ, Vipraio GA, Michalek JE and Lopez YG. Insulin-like growth factor (IGF1) in fibromyalgia (FS), rheumatoid arthritis (RA), osteoarthritis (OA) and healthy normal controls (NC): Roles of diagnosis, age, sex and ethnic origin. Arthritis and Rheumatism 1992;35(S160) * 162.Russell IJ, Michalek JE, Vipraio GA, Lawrence VA, Lessard JA, Briggs BT. Automated reading of joint space on osteoarthritis X-rays: Correlation with clinical manifestations. Arthritis and Rheumatism 1992;35(S133) * 163.Russell IJ, Michalek JE, Lawrence VA, Lessard JA, Briggs BT and May GS. A randomized, placebo (PL) and no-intervention (NI) controlled, trial of intra-articular (IA) 1% sodium hyaluronate (HA) in the treatment of knee osteoarthritis. Arthritis and Rheumatism 1992;35(S132) * 164.Russell IJ, Fletcher EM, Michalek JE, McBroom PC, Hester GG. Treatment of primary fibrositis/fibromyalgia syndrome with ibuprofen and alprazolam. A double-blind, placebo-controlled study. Arthritis Rheum 1991 May;34(5):552-560. * 165.Michalek JE, Wolfe WH, Miner JC. Health status of Air Force veterans occupationally exposed to herbicides in Vietnam. II. Mortality. JAMA 1990 Oct;264(14):1832-1836. * 166.Wolfe WH, Michalek JE, Miner JC, Rahe A, Silva J, Thomas WF, Grubbs WD, Lustik MB, Karrison TG, Roegner RH. Health status of Air Force veterans occupationally exposed to herbicides in Vietnam. I. Physical health. JAMA 1990 Oct;264(14):1824- 1831. * 167.Russell IJ, Michalek JE, Vipraio GA, Fletcher EM, Wall K. Serum amino acids in fibrositis/fibromyalgia syndrome. J Rheumatol Suppl 1989 Nov;19:158-163. * 168.Michalek JE, Mihalko D, Tripathi RC. Cautions on the reanalysis of epidemiologic databases. Stat Med 1989 Jun;8(6):653-664. * 169.Pirkle JL, Wolfe WH, Patterson DG, Needham LL, Michalek JE, Miner JC, Peterson MR, Phillips DL. Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam Veterans of Operation Ranch Hand. J Toxicol Environ Health 1989;27(2):165- 171. * 170.Michalek JE. The value of epidemiology. Applied Industrial Hygiene, Special Issue 1989:68-72. * 171.Russell IJ, Fletcher EM, Tsui J and Michalek JE. Comparisons of rheumatoid arthritis and fibrositis/fibromyalgia syndrome using functional and psychological outcome measures. Arthritis and Rheumatism 1989;32(S70)
  • 38. * 172.Russell IJ, Fletcher EM, Michalek JE, McBroom PC and Hester GG. Efficacy and safety of ibuprofen and alprazolam in the treatment of primary fibrositis/fibromyalgia syndrome. Arthritis and Rheumatism 1989;32(S69) * 173.Russell IJ, Michalek JE, Vipraio GA, Fletcher EM and Wall K. Serum amino acids in fibrositis/fibromyalgia syndrome. Arthritis and Rheumatism 1989;32(S70) * 174.Wolfe WH, Michalek JE, Miner JC, Patterson DG, Needham LL and Pirkle JL. Serum dioxin levels in Air Force Health Study participants preliminary report. Morbidity Mortality Weekly Report 1988;37:309-311. * 175.Russell IJ, Vipraio GA, Michalek JE and Fletcher E. Abnormal T cell subpopulations in fibrositis syndrome. Arthritis and Rheumatism 1988:S99-S99. * 176.Russell IJ, Vipraio GA, Tovar Z, Michalek JE and Fletcher E. Abnormal natural killer cell activity in fibrositis syndrome is responsive in vitro to IL-2. Arthritis and Rheumatism 1988:S24-S24. * 177.Gupta RC, Tripathi RC, Michalek JE and White T. An exact test for the mean of a normal distribution with a known coefficient of variation. Computational Statistics and Data Analysis 1986;3:219-226. * 178.Gupta RC and Michalek JE. On the relationship between the proportional hazard and accelerated failure time models in survival analysis. Statistics and Probability Letters 1985;3:231-234. * 179.Michalek JE, Mihalko D and White T. A Monte Carlo comparison of logrank, Wilcoxon and normal scores procedures on matched and censored data. Communications in Statistics 1985;14(2):449-465. * 180.Michalek JE and Mihalko D. Linear rank procedures for matched data. Biometrics 1984;40:487-491. * 181.Gupta RC, Mehrotra KG and Michalek JE. A small sample test for an absolutely continuous bivariate exponential model. Communications in Statistics 1984;13(14):1735-1740. * 182.Gupta RC and Michalek JE. On Gehan‘s Wilcoxon extension and the accelerated failure time model. Communications in Statistics 1984;13(5):563-566. * 183.Gupta RC and Michalek JE. On the determination of reliability functions via the TTT transform. IEEE Transactions on Reliability 1984;R-(34):175-176. * 184.Michalek JE, Mihalko D. On the use of logrank scores in the analysis of litter-matched data on time to tumour appearance. Stat Med 1983 Jul;2(3):315-326.
  • 39. * 185.Mehrotra KG, Michalek JE, Mihalko D, White T. Score computation for linear rank procedures. Journal of Statistical Computation and Simulation 1983;16:201-211. * 186.Keating JP, Michalek JE and Riley JT. A note on the optimality of the Karhunen-Loeve expansion. Pattern Recognition Letters 1983;1:203-204. * 187.Eisenberg B, Decosse J, Harford F and Michalek JE. Carcinoma of the colon and rectum: the natural history reviewed in 1704 cases. Cancer 1982;49:1131-1134. * 188.Mehrotra KG, Michalek JE and Mihalko D. A relationship between two forms of linear rank procedures for censored data. Biometrika 1982;69:674-676. * 189.Michalek JE, Tripathi RC. The effect of errors in diagnosis and measurement on the estimation of the probability of an event. Journal of the American Statistical Association 1980;75:713-721. * 190.Hensler GL, Mehrotra KG, Michalek JE. A goodness of fit test for multivariate normality. Communications in Statistics 1977;A6(1):33-41. * 191.Michalek JE. Uniform convergence of an empirical CDF based on a relatively small number of order statistics. Communications in Statistics 1976;5(3):241-250. * 192.Hensler GL, Mehrotra KG, Michalek JE. A note on some exact efficiency calculations for survival distributions. Biometrika 1976;64:635-637. Papers Submitted * 1.Muir T, Michalek JE. Contrasting toxicology and epidemiology on safe levels of persistent organic pollutants 2013 Feb PRESENTATIONS: 02/2005 On the Disposition of the Air Force Health Study: An Overview, Board Room NAS Building, Washington, DC (Invited Speaker) 10/2002 Like morning stiffness in rheumatoid arthritis, morning stiffness in fibromyalgia is related to serum hyaluronic acid., American College of Rheumatology, New Orleans, LA (Co-Presenter)
  • 40. 10/2002 Therapy with a central alpha-2-adrenergic agonist [tizanidine] decreases cerebrospinal fluid substance P, and may reduce serum hyaluronic acid as it improves the clinical symptoms of the fibromyalgia syndrome., American College of Rheumatology, New Orleans, LA (Co-Presenter) 10/2002 Correlation of Anti-Polymer Antibodies with Clinical Measures in Fibromyalgia Syndrome., American College of Rheumatology, New Orleans, LA (Co-Presenter) 04/2002 Veterans and Agent Orange: Update 2002 (2003), National Academy of Sciences, Washington, DC (Sole Presenter) Details: First Public Meeting in the 2002 Update Series: "Recent Data from Ranch Hand Studies" 04/2002 Dioxins and Dioxin-like Compounds in the Food Supply: Strategies to Decrease Exposure (2003), National Academy os Sciences (Sole Presenter) Details: Workshop #2–Implication of Dioxin in the Food Supply, Session on Accumulation and Elimination of Dioxins in Humans: “Kinetics of Dioxin Elimination in the Ranch Hand Cohort” 04/2002 Workshop #2-Implication of Dioxin in the Food Supply, Session on Accumulation and Elimination of Dioxins in Humans: "Kinetics of Dioxin Elimination in the Ranch Hand Cohort" (Invited Speaker) 01/2002 Alpha-2 adrenergic agonists: evidence and experience examined, Round Table Series 75, The Royal Society of Medicine Press, Ltd (Co-Presenter) 06/2000 Public Workshop 2: "Dioxin and Diabetes in Ranch Hand Veterans", National Academy of Sciences, Washington, DC (Sole Presenter)
  • 41. 03/2000 Agent Orange:Status of the Air Force Ranch Hand Study, House of Representatives subcommittee on National Security, Veterans Affairs, and International Relations, of the Committee on Government Reform, United States Congress (Invited Speaker) Details: Defended the study against claims that the Air Force, the Food and Drug Administration, and the National Academy of Sciences had collaborated to encumber scientific aspects of the study 07/1999 Veterans and Agent Orange: Herbicide/Dioxin Exposure and Type 2 Diabetes (2000), National Academy of Sciences, Washington, DC (Sole Presenter) Details: Public Workshop 1: "Diabetes and TCDD in the Air Force Health Study" 09/1996 Health Effects in Veterans Exposed to Agent Orange in Vietnam, Committee on Veteran's Affairs, United States Senate (Invited Speaker) Details: Information gathering hearing at which a short summary of results and response to questions from the Committee. 08/1996 Characteristics of the elevated spinal fluid substance P in fibromyalgia syndrome., 8th World Congress on Pain, Vancouver, BC, Canada (Co-Presenter) 04/1996 Health Effects in Children of Individuals Exposed to Agent Orange in Vietnam, Committee on Veterans' Affairs Subcommittee on Hospitals and Health Care, United States House of Representatives (Invited Speaker) 01/1994 Veterans and Agent Orange: Health Effects of Herbicides Used in Vietnam, National Academy of Sciences (Sole Presenter) 12/1992 Scientific Workshop on Exposure Assessment, Session 4: Biomarkers for Exposure Assessment, National Academy of Sciences (Sole Presenter)
  • 42. 11/1989 A rebuttal to "How the military misled Vietnam veterans and their families about the health risks of Agent Orange", House and Senate Committees on Veterean's Affairs staffers, United States Congress (Invited Speaker) Details: Defended the Air Force Health Study against a claim that study investigators had withheld information. 05/1988 A metabolic basis for fibrositis syndrome (FS): The serotonin deficiency hypothesis., ARA Meeting, Nonarticular Rheumatism Study Group (NARSG) Meeting, Houston, TX (Co- Presenter) Details: Accepted for presentation. 05/1988 Agent Orange Legislation and Oversight Hearing, Committee on Veterans' Affairs, One Hundredth Congress, Second Session on S.1692, United States Senate (Invited Speaker) Details: The proposed "Agent Orange Disability Benefits Act of 1987"; S. 1781, The Proposed "Veterans Agent Orange Disability Act of 1987"; and Agent Orange Oversight Issues May 12, 1988. U.S. Government Printing Office, Washington: 1989 Hearing to assess Federal efforts to address the Agent Orange issue. RESEARCH GRANTS: Project #: Funding Agency: VA Title: IPAA for Joel E Michalek(Cadena) Status: Active Period: 06/2014 - 05/2016 Role: Co-Investigator % Effort: 3 Total Costs: $6,788.00 Grant Detail: Failure to isolate patients with pulmonary tuberculosis as a patient safety issue: Defining the problem and estimating its associated costs Despite advances in its control and prevention, tuberculosis (TB) is an important patient safety issue in the US. Texas and other three states account for over half of the US cases. Healthcare Associated TB exposure cohorts continue to occur despite implementation of the CDC’s recommendations for infection prevention, causing significant costs for healthcare systems. However, recent data on factors predicting the clinical features of TB cases leading to exposures, and the costs of contact tracings for healthcare systems are not available. This should be researched in order ensure a safe environment for patients.
  • 43. Project #: 3UL1TR001120-01 Funding Agency: NIH/NCRR Title: Institute For Integration of Medicine & Science: A Partnership to Improve Health(3UL1TR00120-01/Biostatistics)(Clark, Robert) Status: Complete Period: 05/2008 - 04/2015 Role: Co-Investigator % Effort: 20 Total Costs: $424,158.00 Grant Detail: Our mission is to achieve optimal integration of clinical and translational research, education, training, and career development across all UTHSCSA schools and among our partner organizations in the South Texas region. IIMS will focus existing and newly developing resources and intellectual capital on advancing the discipline of clinical and translational research for the improvement of human health. Key function working groups have developed many innovative approaches to providing optimal support for IIMS investigators and programs. Distinctive features of IIMS include: 1) thriving partnerships with key public and private organizations (academic, health care, public health, military), 2) major investments in research resources and infrastructure, 3) the largest cadre of military health care and biomedical research operations in the US, 4) one of the world’s largest primate research colonies, 5) a 46,000 square mile service area populated by predominantly Hispanic residents comprising some of the country’s poorest people, plagued by high rates of health disparities, providing an opportunity, challenge and obligation for us to make a significant impact on human health. Project #: 5M01 RR 001346-2 Funding Agency: NIH Title: General Clinical Research Center: Biostat Core (PI: Clark, Robert) Status: Complete Period: 12/2003 - 04/2009 Role: Co-Investigator % Effort: 20 Total Costs: $726,226.00 Grant Detail: The Biostatistics and Informatics Core of the Frederic C. Bartter General Clinical Research Center (GCRC) provides bio-statistical and data management support for protocols and participates in Educational/training activities for junior investigators. Federal Project #: W911QY-14-1-0005 Funding Agency: Army Med Research Acquisition Activity Title: Evaluation of the Efficacy of a Novel Soft Tissue Clamp Status: Complete Period: 09/2014 - 03/2015 Role: Contributor % Effort: 10 Total Costs:
  • 44. Grant Detail: This is a non-inferiority study of a novel, FDA approved, externally-applied, soft-tissue clamp (iTClamp®, Innovative Trauma Care, Inc., San Antonio, TX, USA) as compared to a properly- placed hasty tourniquet for intact extremity penetrating trauma hemorrhage control, during the “care under fire” phase of the Tactical Combat Casualty Care (TCCC) paradigm. The goal is to determine whether the temporary wound closure clamp provides hemorrhage control comparable to a hasty tourniquet when applied to a non-amputation arterial extremity hemorrhage model. Project #: RP 140685 Funding Agency: CPRIT Title: Modulation of Autophagy - Phase II Study Status: Active Period: 08/2014 - 08/2015 Role: Contributor % Effort: 3 Total Costs: Grant Detail: This will be a randomized, controlled phase II clinical trial of pts with histological documentation of primary colon or rectal adenocarcinoma with metastases, who have received locally and currently approved standard therapies, excluding RGF. Pts will be randomized to RGF or VOR/HCQ, and crossover will be allowed after first progression on the initial therapy. In the single- arm phase study, VOR/HCQ was given daily in 3-week cycles. In this proposed study, we will give VOR/HCQ daily in 4-week cycles, such that this is comparable to the 4-week cycle of RGF (daily for 3 weeks, 1 week off). Project #: 1 R01 FD004400-0 Funding Agency: FDA Title: Phase 2 Study of TH-302 for the Treatment of Glioblastoma Status: Active Period: 08/2014 - 06/2015 Role: Contributor % Effort: 3 Total Costs: Grant Detail: This application attempts to challenge the current clinical paradigm [38] in glioblastoma of uniform treatment for all patients with an anitangiogenic agent to a more individualized treatment regimen based on molecular biomarkers that define the individual tumor’s level of hypoxia, and uses that hypoxia as a target of therapy. This approach is novel, and attempts to refine the potential integration of molecular imaging and biomarker analysis as predictive tools. Moreover, this proposal makes use of a new category of therapeutic; the hypoxia activated pro-drug TH-302, in an attempt to improve survival of an orphan disease with dismal outcomes. Project #: 2 P30 CA054174-1 Funding Agency: NIH/NCRR Title: Cancer Therapy and Research Center at UTHSCSA/Cancer Center Admin(Thompson) Status: Active Period: 08/2009 - 07/2014 Role: Co-Investigator % Effort: 5 Total Costs: $1,029,650.00
  • 45. Grant Detail: This is a P30 Cancer Center Support Grant at the University of Texas Health Science Center at San Antonio. This grant provides funding for the conduct of cancer clinical trials, prevention studies and assistance with statistical design and analysis of translational cancer research projects. Specifically, this is for support of the biostatistics and medical informatics core which has the following aims: provide flexible, cost-efficient services to CTRC basic, clinical and translational researchers; provides services to aid in the administration of the CTRC including monitoring and reporting functions for compliance with local and Federal regulatory requirements, quality assurance review, preparation of reports and analyses for administrative meetings; to provide informatics components for the Protocol Review Committee, the Data Safety Monitoring Committee and to provide statistical assistance with the development and conduct of clinical protocol-based research. Project #: 2 P30 CA054174-1 Funding Agency: NIH/NCI Title: Cancer Therapy and Research Center/Cancer Center Admin Status: Complete Period: 08/2009 - 07/2013 Role: Consultant % Effort: 6 Total Costs: Grant Detail: This is a P30 Cancer Center Support Grant at the University of Texas Health Science Center at San Antonio. This grant provides funding for the conduct of cancer clinical trials, prevention studies and assistance with statistical design and analysis of translational cancer research projects. Specifically, this is for support of the biostatistics and medical informatics core which has the following aims: provide flexible, cost-efficient services to SACI basic, clinical and translational researchers; provides services to aid in the administration of the SACI including monitoring and reporting functions for compliance with local and Federal regulatory requirements, quality assurance review, preparation of reports and analyses for administrative meetings; to provide informatics components for the Protocol Review Committee, the Data Safety Monitoring Committee and to provide statistical assistance with the development and conduct of clinical protocol-based research. Project #: W81XWH-08-2-0109 Funding Agency: Psychological Health and TBI Research Program, Congressionally Directed Medical Research Program Title: The STRONG STAR Multidisciplinary PTSD Research Consortium Status: Complete Period: 09/2008 - 08/2015 Role: Consultant % Effort: Total Costs: $35,000,000.00 Grant Detail: This is a multidisciplinary and multi-institutional proposal to establish a PTSD research consortium in San Antonio focused on the development and evaluation of prevention and treatment programs for combat-related PTSD in active-duty military personnel and recently discharged military veterans. Project #: 1UL1RR025767-01 Funding Agency: NIH/NCRR Title: Institute for Integration of Medicine & Science: A Partnership to Improve Health Status: Complete
  • 46. Period: 05/2008 - 04/2013 Role: Consultant % Effort: 15 Total Costs: Grant Detail: Prinicipal Investigator: Robert Clark, MD Our mission is to achieve optimal integration of clinical and translational research, education, training, and career development across all UTHSCSA schools and among our partner organizations in the South Texas region. IIMS will focus existing and newly developing resources and intellectual capital on advancing the discipline of clinical and translational research for the improvement of human health. Meaningful bidirectional community participation has promoted buy-in from all stakeholders and will remain a key principle as IIMS continues to evolve. IIMS partners have brought together major talent and a broad array of resources to create synergies that add value to all participating organizations, residents of our region and the CTSA network. Key function working groups have developed many innovative approaches to providing optimal support for IIMS investigators and programs. Distinctive features of IIMS include: 1) thriving partnerships with key public and private organizations (academic, health care, public health, military), 2) major investments in research resources and infrastructure, 3) the largest cadre of military health care and biomedical research operations in the US, 4) one of the world’s largest primate research colonies, 5) a 46,000 square mile service area populated by predominantly Hispanic residents comprising some of the country’s poorest people, plagued by high rates of health disparities, providing an opportunity, challenge and obligation for us to make a significant impact on human health. Project #: R01CA 133229-01 Funding Agency: NIH/NCI Title: Therapeutic Targets in Alveolar Rhabdomyosarcoma Status: Complete Period: 04/2008 - 03/2013 Role: Co-Investigator % Effort: 5 Total Costs: $1,539,045.00 Grant Detail: The primary objective for this project will be to delineate the PDGFR-A signaling pathway to rhabdomyosarcome by functional testing in vitro with the second aim to determine the pathophysiologicl impact of specific and exclusive PDGFR-A blockade for rhabdomyosarcome in vivo. Project #: 5K23DA022297-04 Funding Agency: NIDA Title: Treatment of Opioid Dependence and Chronic Pain Status: Complete Period: 04/2008 - 03/2013 Role: Consultant % Effort: Total Costs: Grant Detail: The goal of this project is to obtain advanced training in the treatmetn of chronic pain and opioid dependence in order to conduct treatment-related research on co-occurring chronic pain and opioid dependence. The primary research objective is to develop an integrated psychosocial treatmetn for co-occurring chronic pain and opioid dependence based on formative research conducted during the award period.
  • 47. Project #: 1R01MH080127-01 Funding Agency: NIMH Title: Gene-Environment Interactions and Risk of Depression in Youth with Diabetes (PI: Delgado, Pedro) Status: Not Funded Period: 10/2007 - 09/2012 Role: Co-Investigator % Effort: Total Costs: $2,535,090.00 Grant Detail: The major goals of this project are to examine how genetic factors, environmental stressors and brain development interact to determine the onset of mood disorders. Project #: W81XWH-07-0717 Funding Agency: Dept of the Army Title: A Civilian/Military Trauma Institute: Resuscitation-Monitoring-Metabolic Control Status: Complete Period: 09/2007 - 09/2013 Role: Co-Investigator % Effort: Total Costs: $5,275,068.00 Grant Detail: Establish procedures to identify upon admission to the emergency department those patients who may require a blood transusion. These procedures will be uniformly implemented at all three Level 1 trauma centers, UTHSCSA, BAMC AND WHMC. The measures to be employed to asses coagulation status of patients with traumatic injuries upon admission will include point of care assessment of aactivated clotting time (ACT) and INR, and laboratory thrombelastography (TEG). The purpose of this effort is to improve patient care and reduce resource utilization. A Department of Defense grant supporting a wide variety of research projects directed towards resuscitation, metabolic control and physiologic monitoring during critical illness. Project #: DAMD17-03-C-0071 Funding Agency: Dept. of the Army Title: Feasibility Study and Demonstration Project for a Joint Military/Civilian Trauma Institute with a Burn Center Status: Complete Period: 09/2005 - 10/2008 Role: Co-Investigator % Effort: 10 Total Costs: $1,847,713.93 Grant Detail: A grant supporting the research, clinical and educational collaboration between UTHSCSA, Brooke Army Medical Center, the U.S. Army Institute for Surgical Research, Wilford Hall Medical Center and University Hospital. Project #: 117549 Funding Agency: NIH/NIAID Title: New Animal Models for Invasive Aspergillosis (N01-AI-30041) Status: Complete Period: 08/2003 - 08/2010
  • 48. Role: Co-Investigator % Effort: Total Costs: $7,149,604.00 Grant Detail: The overall objective of this proposal is to establish and standardize animal models of invasive aspergillosis that can be used to evaluate genomic information on the pathogenicity and virulence of Aspergillus in order to improve diagnosis and therapy of invasive aspergillosis. We are the lead site for this multi-center collaboration involving sub-contracts at UCLA, MD Anderson, McGill (Montreal, Canada) & Univ of Manchester (UK). Project #: 276700F1 Funding Agency: United States Air Force Title: The Air Force Health Study (PI: Michalek, Joel) Status: Complete Period: 01/1980 - 10/2006 Role: Principal Investigator % Effort: 100 Total Costs: 140,000,000.00 Grant Detail: The purpose of this cohort study was to determine whether adverse health was associated with exposure to Agent Orange in US Air Force veterans of Operation Ranch Hand. Funded under program element 0605306F in the United States Federal Budget. Oversight by the House and Senate Veterans Affairs Committees of the United States Congress and peer-reviewed by the National Academy of Sciences and the US Food and Drug Administration. SERVICE 01/2010-12/2010 Prostate Cancer Peer Review Committee Member Clinical Trial Award/Innovative Treatment Evaluation Award (CTA/ITEA) peer review panel 01/1998-12/1998 A metabolic basis for fibrositis syndrome (FS): Consultant The serotonin deficiency hypothesis. Accepted for presentation at the Nonarticular Rheumatism Study Group (NARSG) meeting during the ARA meeting, Houston, TX 01/1992-12/1992 Early life traumas and confiding in fibromyalgia syndrome(FS) Consultant rheumatoid arthritis (RA), osteoarthritis (OA) and healthy normal controls (NC): Roles of diagnosis, age, sex and ethnic origin. Arthritis and Rheumatism 01/1992-12/1992 Insulin-like growth factor (IGFI) in fibromyalgia (FS) Consultant