Webinar presentation for the mHealth Israel community by Joe Jankowski, PhD, Director, Innovation, Henry Ford Innovation Institute at the Henry Ford Health System in Detroit, Michigan. This is a systematic review of the key barriers inhibiting adoption of new technologies across health systems, with an emphasis on specific challenges for startups. Key factors include existing workflows, noise in the system, procurement cycle, costs, IT issues, self interests, value proposition, validation plan, Payer inefficiencies. Suggestion is to partner early, align to a major current problem and to focus on the health system rather than your own product. Also, build out a diverse team of stakeholders, use retrospective data to conduct scenario analysis, set appropriate expectations for time and cost.