This document discusses metabolic reprogramming in cancer cells. It explains that cancer cells reprogram their metabolism compared to normal cells in order to support proliferation, inhibit apoptosis, promote angiogenesis and metastasis, and develop chemoresistance. Specifically, cancer cells shift towards aerobic glycolysis (known as the Warburg effect), increase glutaminolysis, upregulate the pentose phosphate pathway, enhance mitochondrial biogenesis and lipid synthesis, and boost fatty acid oxidation - all to support the metabolic needs of rapid growth and survival. This metabolic reprogramming in cancer cells is exploited for diagnostic imaging techniques like PET and MRI that can detect increased uptake of radiolabeled glucose, glutamine, fatty acids and other metabolites in tumors.