This meta-analysis reviewed 25 controlled clinical trials involving 1332 patients to evaluate the efficacy of pulsed radio frequency energy (PRFE) therapy for postoperative pain and edema, nonpostoperative pain and edema, and wound healing. A vote-counting method found more positive outcomes than neutral or negative outcomes for each clinical application. A statistical combination of P-values also found statistically significant improvements in pain, edema reduction, and wound healing outcomes. The analysis provides strong statistical evidence that PRFE therapy is an effective treatment for postoperative and nonpostoperative pain and edema as well as for wound healing applications.
This study investigated the efficacy of pulsed electromagnetic field therapy (PEMF) in reducing delayed onset muscle soreness (DOMS) in marathon runners. A double-blind randomized controlled trial assigned 133 marathon runners to either an active PEMF device or placebo device to use for 20 minutes, 4 times per day for 5 days after a marathon. The primary outcome was thigh pain assessed using a visual analog scale during squats. Subjects using the active PEMF device had significantly lower pain scores compared to the placebo group, indicating PEMF reduced DOMS in marathon runners.
This randomized, double-blind pilot study examined the effects of pulsed electromagnetic field (PEMF) therapy on pain in patients with early knee osteoarthritis. 34 patients were randomly assigned to either an active PEMF device group (n=15) or a sham device group (n=19). The PEMF signal was designed to modulate the calcium/calmodulin dependent nitric oxide signaling pathway. Results showed a 50% reduction in pain scores from baseline in the active group starting on day 1 and persisting to day 42, while no significant reduction was seen in the sham group. The overall decrease in pain was nearly threefold greater in the active group. The rapid and sustained pain relief seen with PEMF therapy suggests it may reduce inflammation
1) A double-blind randomized controlled study evaluated a wearable pulsed radiofrequency electromagnetic field (PRFE) device for treating plantar fasciitis.
2) 70 subjects with plantar fasciitis were randomly assigned either an active or placebo PRFE device to wear overnight for 7 days.
3) The active PRFE device showed a progressive 40% decline in morning heel pain over 7 days, significantly greater than the 7% decline in the control group, demonstrating PRFE's potential as a drug-free noninvasive treatment for reducing plantar fasciitis pain.
The document discusses varying the frequency and intensity of transcutaneous electrical nerve stimulation (TENS) for treating acute and chronic pain. It summarizes several studies that investigated:
1) The effectiveness of high vs low frequency TENS for reducing hyperalgesia and whether activation of cutaneous or deep tissue afferents is responsible for TENS analgesia.
2) The impact of varying TENS frequency, intensity, and pulse duration on primary and secondary hyperalgesia in an animal model of inflammation.
3) The short and long-term effects of high frequency TENS on motor cortex excitability in humans.
4) The effectiveness of high vs low frequency TENS for reversing hyper
Pulsed radio frequency electromagnetic field (PRFE) therapy has been shown to accelerate wound healing through several mechanisms. PRFE increases nitric oxide production, which promotes cell proliferation, vascularization and collagen deposition. It also up-regulates growth factors involved in tissue repair such as FGF-2. While early uses of RF therapy involved tissue heating, recent evidence indicates PRFE provides therapeutic benefits through non-thermal mechanisms as well as a small thermal component. PRFE has been demonstrated to reduce inflammation and enhance each phase of wound healing in both animal and clinical studies.
Postoperative pain is a major concern for patients and doctors. This preliminary study investigated the use of a wearable pulsed radiofrequency energy (PRFE) device to control postoperative pain in 18 women undergoing breast augmentation surgery. Patients were randomly assigned to receive either an active or placebo PRFE device. Those receiving the active device experienced significantly lower pain scores over 7 days as measured by a visual analog scale. They also took fewer narcotic pain medications than those receiving the placebo. The findings suggest PRFE therapy is an effective non-drug method for controlling postoperative pain.
ZMPCZM017000.11.11 Home based EMG Triggered stimulation in chronic strokepainezeeman
This study investigated the feasibility and efficacy of home-based electromyography-triggered neuromuscular stimulation (ETMS) for chronic stroke patients with limited wrist extension. Twelve chronic stroke patients were randomly assigned to receive either 8 weeks of ETMS followed by 8 weeks of home exercises, or vice versa. Outcome measures assessed wrist extension range of motion and impairment scales. Results showed that both groups increased active wrist extension by 21 degrees after ETMS, but no significant changes on impairment scales. The study concluded that home-based ETMS is feasible and can increase wrist extension, but does not significantly impact impairment scales.
This document provides an overview of pulsed radio frequency energy (PRFE) therapy, which uses pulsed radio frequency in the 13-27.12 MHz range for medical applications without substantial tissue heating. The document summarizes the technology, intended uses for postoperative and non-postoperative pain/edema and wound healing, proposed mechanisms of action through electric field interactions with cell membranes, and clinical efficacy studies showing benefits for pain/edema and wound healing. Key PRFE devices and parameters used in clinical studies are also outlined.
This study investigated the efficacy of pulsed electromagnetic field therapy (PEMF) in reducing delayed onset muscle soreness (DOMS) in marathon runners. A double-blind randomized controlled trial assigned 133 marathon runners to either an active PEMF device or placebo device to use for 20 minutes, 4 times per day for 5 days after a marathon. The primary outcome was thigh pain assessed using a visual analog scale during squats. Subjects using the active PEMF device had significantly lower pain scores compared to the placebo group, indicating PEMF reduced DOMS in marathon runners.
This randomized, double-blind pilot study examined the effects of pulsed electromagnetic field (PEMF) therapy on pain in patients with early knee osteoarthritis. 34 patients were randomly assigned to either an active PEMF device group (n=15) or a sham device group (n=19). The PEMF signal was designed to modulate the calcium/calmodulin dependent nitric oxide signaling pathway. Results showed a 50% reduction in pain scores from baseline in the active group starting on day 1 and persisting to day 42, while no significant reduction was seen in the sham group. The overall decrease in pain was nearly threefold greater in the active group. The rapid and sustained pain relief seen with PEMF therapy suggests it may reduce inflammation
1) A double-blind randomized controlled study evaluated a wearable pulsed radiofrequency electromagnetic field (PRFE) device for treating plantar fasciitis.
2) 70 subjects with plantar fasciitis were randomly assigned either an active or placebo PRFE device to wear overnight for 7 days.
3) The active PRFE device showed a progressive 40% decline in morning heel pain over 7 days, significantly greater than the 7% decline in the control group, demonstrating PRFE's potential as a drug-free noninvasive treatment for reducing plantar fasciitis pain.
The document discusses varying the frequency and intensity of transcutaneous electrical nerve stimulation (TENS) for treating acute and chronic pain. It summarizes several studies that investigated:
1) The effectiveness of high vs low frequency TENS for reducing hyperalgesia and whether activation of cutaneous or deep tissue afferents is responsible for TENS analgesia.
2) The impact of varying TENS frequency, intensity, and pulse duration on primary and secondary hyperalgesia in an animal model of inflammation.
3) The short and long-term effects of high frequency TENS on motor cortex excitability in humans.
4) The effectiveness of high vs low frequency TENS for reversing hyper
Pulsed radio frequency electromagnetic field (PRFE) therapy has been shown to accelerate wound healing through several mechanisms. PRFE increases nitric oxide production, which promotes cell proliferation, vascularization and collagen deposition. It also up-regulates growth factors involved in tissue repair such as FGF-2. While early uses of RF therapy involved tissue heating, recent evidence indicates PRFE provides therapeutic benefits through non-thermal mechanisms as well as a small thermal component. PRFE has been demonstrated to reduce inflammation and enhance each phase of wound healing in both animal and clinical studies.
Postoperative pain is a major concern for patients and doctors. This preliminary study investigated the use of a wearable pulsed radiofrequency energy (PRFE) device to control postoperative pain in 18 women undergoing breast augmentation surgery. Patients were randomly assigned to receive either an active or placebo PRFE device. Those receiving the active device experienced significantly lower pain scores over 7 days as measured by a visual analog scale. They also took fewer narcotic pain medications than those receiving the placebo. The findings suggest PRFE therapy is an effective non-drug method for controlling postoperative pain.
ZMPCZM017000.11.11 Home based EMG Triggered stimulation in chronic strokepainezeeman
This study investigated the feasibility and efficacy of home-based electromyography-triggered neuromuscular stimulation (ETMS) for chronic stroke patients with limited wrist extension. Twelve chronic stroke patients were randomly assigned to receive either 8 weeks of ETMS followed by 8 weeks of home exercises, or vice versa. Outcome measures assessed wrist extension range of motion and impairment scales. Results showed that both groups increased active wrist extension by 21 degrees after ETMS, but no significant changes on impairment scales. The study concluded that home-based ETMS is feasible and can increase wrist extension, but does not significantly impact impairment scales.
This document provides an overview of pulsed radio frequency energy (PRFE) therapy, which uses pulsed radio frequency in the 13-27.12 MHz range for medical applications without substantial tissue heating. The document summarizes the technology, intended uses for postoperative and non-postoperative pain/edema and wound healing, proposed mechanisms of action through electric field interactions with cell membranes, and clinical efficacy studies showing benefits for pain/edema and wound healing. Key PRFE devices and parameters used in clinical studies are also outlined.
ZMPCZM016000.11.20 TENS can reduce postoperative analgesic consumption.A meta...painezeeman
TENS can reduce postoperative analgesic consumption according to a meta-analysis of 21 randomized controlled trials. The analysis found that TENS reduced overall analgesic use by 26.5% compared to placebo. For trials using strong, subnoxious TENS at adequate frequencies, analgesic consumption was reduced by 35.5% compared to 4.1% for trials without these optimal parameters. The difference between optimal and non-optimal TENS was statistically significant, indicating TENS can significantly reduce pain medication needs when administered optimally.
ZMPCZM016000.11.09 Electrotherpay study summaries for surgeons provided by me...painezeeman
1) Several studies examined the effects of transcutaneous electrical nerve stimulation (TENS) and electrical muscle stimulation (EMS) after shoulder and knee surgeries.
2) The studies found that TENS reduced pain levels and analgesic consumption after shoulder surgery compared to placebo. EMS improved quadriceps strength and gait more than voluntary exercise alone after ACL reconstruction.
3) Home interferential current therapy also reduced pain, edema, and improved range of motion more than placebo after ACL reconstruction, meniscectomy, or knee chondroplasty procedures.
ZMPCZM016000.11.23 Electrotherapy for pain managementpainezeeman
This document summarizes research on the use of electrotherapy/electrical stimulation for pain management. It discusses two major theories for how electrotherapy relieves pain through gate control and opiate-mediated control. Research studies cited found electrotherapy effective at reducing pain and improving function for chronic musculoskeletal pain, low back pain, and post-operative knee pain. Meta-analyses showed significant decreases in pain from electrical nerve stimulation and reductions in analgesic consumption when using adequate stimulation parameters.
ZMPCZM016000.11.07 Analgesic effects of TENS & IFC on heat pain in healthy su...painezeeman
This study examined the analgesic effects of transcutaneous electrical nerve stimulation (TENS) and interferential currents (IFC) on heat pain thresholds in healthy subjects. 48 subjects were randomly assigned to receive either TENS, IFC, or no stimulation for 30 minutes. Heat pain thresholds were measured before, during, and after stimulation. Both TENS and IFC significantly increased heat pain thresholds during stimulation compared to no stimulation. While the effect of TENS did not last long after stimulation, IFC maintained elevated heat pain thresholds for at least 30 minutes following stimulation. The study concluded that both TENS and IFC can effectively reduce heat pain sensitivity in healthy subjects, with IFC having longer-lasting effects.
ZMPCZM016000.11.22 effect of the frequency of TENS on the postoperative opio...painezeeman
This study examined the effects of different frequencies of transcutaneous electrical nerve stimulation (TENS) on postoperative opioid requirements. 100 women undergoing gynecological surgery received patient-controlled analgesia and were assigned to receive sham TENS, low-frequency TENS, high-frequency TENS, or mixed-frequency TENS. Mixed-frequency TENS provided the greatest opioid-sparing effect, decreasing morphine requirements by 53% compared to sham TENS. Low and high frequencies also decreased requirements by 32% and 35% respectively. All active TENS groups had shorter PCA therapy duration and less nausea, dizziness, and itching than the sham group.
ZMPCZM016000.11.10 New perspectives in Edema control Via Electrical Stimulationpainezeeman
This document summarizes the historical evidence for using electrical stimulation (ES), particularly high-voltage pulsed current (HVPC), to treat acute edema. It finds that while ES has been commonly used anecdotally for over 200 years, there is little controlled research to support its efficacy. The few early studies that reported benefits of HVPC provided little evidence and no references. More recent animal studies have found no significant effects of HVPC on existing edema. Overall, the document concludes that while HVPC is frequently advocated for edema control, the evidence from controlled studies to support its therapeutic effects is still remarkably weak.
1) The study aimed to evaluate the effects of capacitive and resistive electric transfer (CRet) and hotpack (HP) on hemoglobin saturation and tissue temperature in the lower paraspinal muscle of 13 healthy males.
2) Total hemoglobin and oxygenated hemoglobin were significantly higher in the CRet group than the HP group for 30 minutes after intervention. Tissue temperature at 10mm and 20mm depths were also significantly higher in the CRet group than HP group from 10 to 30 minutes after intervention.
3) Both CRet and HP increased hemoglobin saturation and tissue temperature more than the sham intervention. However, the effect on hemoglobin saturation was greater with CRet, and CRet warmed
This article reviews recent literature on the application of transcutaneous electrical nerve stimulation (TENS) for pain management. Several studies have found TENS to be effective for acute postoperative pain, reducing medication needs and facilitating earlier recovery. TENS placed near surgical incisions reduced pain and medication requirements after procedures like laparotomy, cholecystectomy, and laminectomy. TENS may also benefit rehabilitation after knee surgery by reducing pain and narcotic use, allowing for earlier quadriceps strengthening and range of motion. While specific stimulation settings do not seem to impact outcomes, proper electrode placement is important. Overall, TENS is an effective non-pharmacological option for acute pain that facilitates recovery after surgery and injury.
This document summarizes and discusses several articles on physical medicine and rehabilitation (PMR) topics that were published in recent issues of various journals. The articles cover a range of topics including the treatment of 12th rib syndrome, the use of the tourniquet ischemia test to diagnose complex regional pain syndrome, physiotherapy interventions for treating spasticity, a telehealth intervention to increase fitness for those with spinal cord injuries, spinal cord involvement in COVID-19, the use of local anesthetic injections in athletes, and a comparison of video-based and text-based physical activity interventions. The document also provides an introduction and welcome from the editor as well as information about new contributors.
This study aims to evaluate the efficacy of capacitive resistive monopolar radiofrequency (CRMRF) at 448 kHz as an adjunct treatment to physiotherapeutic techniques for reducing pain and improving quality of life in patients with chronic pelvic pain syndrome (CPPS). The study involves an 80-patient randomized controlled trial comparing a CRMRF activated group to a CRMRF deactivated group, both receiving physiotherapy. Outcome measures include pain levels, quality of life, kinesiophobia, and catastrophizing, which will be assessed at baseline and weeks 6 and 10. The results may show whether CRMRF provides benefits when added to physiotherapy and pain education for CPPS patients.
The article discusses the impacts of the COVID-19 pandemic on physiatry and rehabilitation medicine. It highlights how physiatrists played a vital role in the front lines during the pandemic by converting rehabilitation units and innovating care delivery. However, the pandemic has also caused significant disruptions and stress for medical practices through reduced patient volumes, higher costs, and threats of reimbursement cuts from insurers and governments. Moving forward, physicians are questioning the level of support they will receive from their employers and the government given the sacrifices many have made during the pandemic.
ZMPCZM017000.11.03 Carey Experimentation on brain researchPainezee Specialist
This study investigated the effects of intensive neuromuscular electrical stimulation (NMES) treatment at home over 3 weeks on functional improvements and cortical changes in subjects with chronic stroke. 16 subjects were randomly assigned to either a true NMES treatment group or a sham treatment group. Both groups underwent testing before and after treatment, and the sham group was also tested after crossing over to the true treatment. The true NMES group showed improvements in measures of hand function and strength, while the sham group did not improve initially but did improve after crossing over. Functional MRI revealed increased cortical activation in the ipsilateral somatosensory cortex following true NMES treatment. The findings suggest NMES may stimulate cortical sensory areas to enable improved motor function in subjects
This randomized controlled trial evaluated the effectiveness of low-level laser therapy (LLT) for treating chronic knee pain. 126 patients with knee osteoarthritis were randomly assigned to receive either active laser treatment or sham laser treatment over 12 sessions within 4 weeks. The primary outcome was pain level measured using a visual analog scale (VAS) from 0-10. Results showed that the active laser treatment provided significant pain relief and osteoarthritic improvements compared to the sham laser, with statistical significance of p<0.01 in reduced VAS scores from baseline to 30-day follow-up. The laser treatment was thus found to be an effective adjunctive therapy for chronic knee pain.
This meta-analysis reviewed 22 randomized controlled trials involving 1014 patients to determine the effectiveness of low-level laser therapy (LLLT) for pain relief in various joint areas. The average methodological quality score of the trials was 7.96 out of 10. The analysis found that 11 trials reported positive effects of LLLT for pain relief while 11 reported negative effects. However, when pooling the results, the mean weighted difference in pain reduction on a visual analogue scale was 13.96 mm in favor of the active LLLT groups, indicating LLLT provides statistically significant pain relief for joints. Restricting the analysis to trials using energy doses within previously suggested therapeutic windows produced even greater mean pain relief of 19.88-21
Balancing Risks and Benefits of Regional AnaesthesiaColin McCartney
This document discusses the benefits and risks of regional anesthesia. It notes that regional anesthesia provides significant benefits for patients such as better pain control, reduced complications, and faster recovery. However, risks are also present though low. The document emphasizes taking a pragmatic approach that balances the benefits and risks for each individual patient. It also stresses the importance of clear explanation and documentation of informed consent. Proper training, use of standardized techniques, and a focus on patient safety are recommended to maximize benefits and minimize risks.
Pharmaceutical Comparative Effectiveness Research AbstractLona Vincent
This document summarizes several research studies and articles in the field of health economics and outcomes research. It discusses trends in the use of electronic medical records in outcomes research from 2001-2010, with the number of studies increasing over time. It also reviews characteristics of homeless patients using inpatient and emergency services compared to non-homeless patients. Additionally, it compares the role of health technology assessment systems in reimbursement and market access between Turkey and Poland.
This systematic review evaluated regional analgesic techniques for post-thoracotomy pain management, including thoracic epidural, paravertebral block, intrathecal, intercostal, and interpleural methods. The review found that continuous paravertebral block provided analgesia comparable to thoracic epidural with fewer side effects. Paravertebral block also reduced pulmonary complications versus systemic opioids, though epidural did not. Epidural was superior to intrathecal or intercostal techniques, which were still better than systemic opioids. Interpleural analgesia was inadequate. The review concluded that either epidural with local anesthetic plus opioid or continuous paravertebral block with local anesthetic can be recommended, with intrathecal opioid
This document summarizes the results of a study that evaluated the health care resource utilization and costs of patients with symptomatic multiple myeloma in the United Kingdom. The study found that the average total cost per treatment line was £34,296, with most costs attributed to anti-tumor drugs. The average cost per month of active treatment was £5,168. For patients receiving best supportive care after discontinuing active treatment, the average total cost was £1,444 if they progressed or £2,480 if they did not progress before death.
Three studies found that direct access to physical therapists significantly reduced waiting times for treatment compared to referral through consultants. Direct access also reduced pressure on consultant outpatient clinics by decreasing unnecessary referrals in two studies. One randomized controlled trial found slightly better patient recovery times and higher patient assessments of progress with direct access. However, most studies found no significant differences in the number of treatment sessions, recovery time, or return to work between direct access models and consultant referral models of physical therapy.
Module 4 Submodule 4. 2 Final June 2007Flavio Guzmán
The document discusses key considerations for clinicians in evaluating the results of drug clinical trials. It emphasizes the importance of critically assessing trial design, results, and whether the findings warrant changing clinical practice. Clinicians are advised to consider factors like trial methodology, potential biases, statistical/clinical significance, applicability to their patients, and safety. The document provides guidance on how to distinguish high-quality trials that produce useful results for patient care.
To Determine Preference of Shoulder Pain Management by General Physicians in ...suppubs1pubs1
Rotator cuff muscles are functionally active and provide stability to the shoulder joint and also thereby allow the full Range of Motion (ROM) by moving the head of humerus in the glenoid cavity. Any tear or fragility of the rotator cuff muscles can cause the dislocation or instability and hence damaging other muscles specially the long head of biceps muscle. The diseases related to the supraspinatus tendon are frequently linked with the long head of the biceps tendon. Other cause of chronic shoulder pain is the adhesive capsulitis with large prevalence rates of more than 5.3% in the general target population [3].
ZMPCZM016000.11.20 TENS can reduce postoperative analgesic consumption.A meta...painezeeman
TENS can reduce postoperative analgesic consumption according to a meta-analysis of 21 randomized controlled trials. The analysis found that TENS reduced overall analgesic use by 26.5% compared to placebo. For trials using strong, subnoxious TENS at adequate frequencies, analgesic consumption was reduced by 35.5% compared to 4.1% for trials without these optimal parameters. The difference between optimal and non-optimal TENS was statistically significant, indicating TENS can significantly reduce pain medication needs when administered optimally.
ZMPCZM016000.11.09 Electrotherpay study summaries for surgeons provided by me...painezeeman
1) Several studies examined the effects of transcutaneous electrical nerve stimulation (TENS) and electrical muscle stimulation (EMS) after shoulder and knee surgeries.
2) The studies found that TENS reduced pain levels and analgesic consumption after shoulder surgery compared to placebo. EMS improved quadriceps strength and gait more than voluntary exercise alone after ACL reconstruction.
3) Home interferential current therapy also reduced pain, edema, and improved range of motion more than placebo after ACL reconstruction, meniscectomy, or knee chondroplasty procedures.
ZMPCZM016000.11.23 Electrotherapy for pain managementpainezeeman
This document summarizes research on the use of electrotherapy/electrical stimulation for pain management. It discusses two major theories for how electrotherapy relieves pain through gate control and opiate-mediated control. Research studies cited found electrotherapy effective at reducing pain and improving function for chronic musculoskeletal pain, low back pain, and post-operative knee pain. Meta-analyses showed significant decreases in pain from electrical nerve stimulation and reductions in analgesic consumption when using adequate stimulation parameters.
ZMPCZM016000.11.07 Analgesic effects of TENS & IFC on heat pain in healthy su...painezeeman
This study examined the analgesic effects of transcutaneous electrical nerve stimulation (TENS) and interferential currents (IFC) on heat pain thresholds in healthy subjects. 48 subjects were randomly assigned to receive either TENS, IFC, or no stimulation for 30 minutes. Heat pain thresholds were measured before, during, and after stimulation. Both TENS and IFC significantly increased heat pain thresholds during stimulation compared to no stimulation. While the effect of TENS did not last long after stimulation, IFC maintained elevated heat pain thresholds for at least 30 minutes following stimulation. The study concluded that both TENS and IFC can effectively reduce heat pain sensitivity in healthy subjects, with IFC having longer-lasting effects.
ZMPCZM016000.11.22 effect of the frequency of TENS on the postoperative opio...painezeeman
This study examined the effects of different frequencies of transcutaneous electrical nerve stimulation (TENS) on postoperative opioid requirements. 100 women undergoing gynecological surgery received patient-controlled analgesia and were assigned to receive sham TENS, low-frequency TENS, high-frequency TENS, or mixed-frequency TENS. Mixed-frequency TENS provided the greatest opioid-sparing effect, decreasing morphine requirements by 53% compared to sham TENS. Low and high frequencies also decreased requirements by 32% and 35% respectively. All active TENS groups had shorter PCA therapy duration and less nausea, dizziness, and itching than the sham group.
ZMPCZM016000.11.10 New perspectives in Edema control Via Electrical Stimulationpainezeeman
This document summarizes the historical evidence for using electrical stimulation (ES), particularly high-voltage pulsed current (HVPC), to treat acute edema. It finds that while ES has been commonly used anecdotally for over 200 years, there is little controlled research to support its efficacy. The few early studies that reported benefits of HVPC provided little evidence and no references. More recent animal studies have found no significant effects of HVPC on existing edema. Overall, the document concludes that while HVPC is frequently advocated for edema control, the evidence from controlled studies to support its therapeutic effects is still remarkably weak.
1) The study aimed to evaluate the effects of capacitive and resistive electric transfer (CRet) and hotpack (HP) on hemoglobin saturation and tissue temperature in the lower paraspinal muscle of 13 healthy males.
2) Total hemoglobin and oxygenated hemoglobin were significantly higher in the CRet group than the HP group for 30 minutes after intervention. Tissue temperature at 10mm and 20mm depths were also significantly higher in the CRet group than HP group from 10 to 30 minutes after intervention.
3) Both CRet and HP increased hemoglobin saturation and tissue temperature more than the sham intervention. However, the effect on hemoglobin saturation was greater with CRet, and CRet warmed
This article reviews recent literature on the application of transcutaneous electrical nerve stimulation (TENS) for pain management. Several studies have found TENS to be effective for acute postoperative pain, reducing medication needs and facilitating earlier recovery. TENS placed near surgical incisions reduced pain and medication requirements after procedures like laparotomy, cholecystectomy, and laminectomy. TENS may also benefit rehabilitation after knee surgery by reducing pain and narcotic use, allowing for earlier quadriceps strengthening and range of motion. While specific stimulation settings do not seem to impact outcomes, proper electrode placement is important. Overall, TENS is an effective non-pharmacological option for acute pain that facilitates recovery after surgery and injury.
This document summarizes and discusses several articles on physical medicine and rehabilitation (PMR) topics that were published in recent issues of various journals. The articles cover a range of topics including the treatment of 12th rib syndrome, the use of the tourniquet ischemia test to diagnose complex regional pain syndrome, physiotherapy interventions for treating spasticity, a telehealth intervention to increase fitness for those with spinal cord injuries, spinal cord involvement in COVID-19, the use of local anesthetic injections in athletes, and a comparison of video-based and text-based physical activity interventions. The document also provides an introduction and welcome from the editor as well as information about new contributors.
This study aims to evaluate the efficacy of capacitive resistive monopolar radiofrequency (CRMRF) at 448 kHz as an adjunct treatment to physiotherapeutic techniques for reducing pain and improving quality of life in patients with chronic pelvic pain syndrome (CPPS). The study involves an 80-patient randomized controlled trial comparing a CRMRF activated group to a CRMRF deactivated group, both receiving physiotherapy. Outcome measures include pain levels, quality of life, kinesiophobia, and catastrophizing, which will be assessed at baseline and weeks 6 and 10. The results may show whether CRMRF provides benefits when added to physiotherapy and pain education for CPPS patients.
The article discusses the impacts of the COVID-19 pandemic on physiatry and rehabilitation medicine. It highlights how physiatrists played a vital role in the front lines during the pandemic by converting rehabilitation units and innovating care delivery. However, the pandemic has also caused significant disruptions and stress for medical practices through reduced patient volumes, higher costs, and threats of reimbursement cuts from insurers and governments. Moving forward, physicians are questioning the level of support they will receive from their employers and the government given the sacrifices many have made during the pandemic.
ZMPCZM017000.11.03 Carey Experimentation on brain researchPainezee Specialist
This study investigated the effects of intensive neuromuscular electrical stimulation (NMES) treatment at home over 3 weeks on functional improvements and cortical changes in subjects with chronic stroke. 16 subjects were randomly assigned to either a true NMES treatment group or a sham treatment group. Both groups underwent testing before and after treatment, and the sham group was also tested after crossing over to the true treatment. The true NMES group showed improvements in measures of hand function and strength, while the sham group did not improve initially but did improve after crossing over. Functional MRI revealed increased cortical activation in the ipsilateral somatosensory cortex following true NMES treatment. The findings suggest NMES may stimulate cortical sensory areas to enable improved motor function in subjects
This randomized controlled trial evaluated the effectiveness of low-level laser therapy (LLT) for treating chronic knee pain. 126 patients with knee osteoarthritis were randomly assigned to receive either active laser treatment or sham laser treatment over 12 sessions within 4 weeks. The primary outcome was pain level measured using a visual analog scale (VAS) from 0-10. Results showed that the active laser treatment provided significant pain relief and osteoarthritic improvements compared to the sham laser, with statistical significance of p<0.01 in reduced VAS scores from baseline to 30-day follow-up. The laser treatment was thus found to be an effective adjunctive therapy for chronic knee pain.
This meta-analysis reviewed 22 randomized controlled trials involving 1014 patients to determine the effectiveness of low-level laser therapy (LLLT) for pain relief in various joint areas. The average methodological quality score of the trials was 7.96 out of 10. The analysis found that 11 trials reported positive effects of LLLT for pain relief while 11 reported negative effects. However, when pooling the results, the mean weighted difference in pain reduction on a visual analogue scale was 13.96 mm in favor of the active LLLT groups, indicating LLLT provides statistically significant pain relief for joints. Restricting the analysis to trials using energy doses within previously suggested therapeutic windows produced even greater mean pain relief of 19.88-21
Balancing Risks and Benefits of Regional AnaesthesiaColin McCartney
This document discusses the benefits and risks of regional anesthesia. It notes that regional anesthesia provides significant benefits for patients such as better pain control, reduced complications, and faster recovery. However, risks are also present though low. The document emphasizes taking a pragmatic approach that balances the benefits and risks for each individual patient. It also stresses the importance of clear explanation and documentation of informed consent. Proper training, use of standardized techniques, and a focus on patient safety are recommended to maximize benefits and minimize risks.
Pharmaceutical Comparative Effectiveness Research AbstractLona Vincent
This document summarizes several research studies and articles in the field of health economics and outcomes research. It discusses trends in the use of electronic medical records in outcomes research from 2001-2010, with the number of studies increasing over time. It also reviews characteristics of homeless patients using inpatient and emergency services compared to non-homeless patients. Additionally, it compares the role of health technology assessment systems in reimbursement and market access between Turkey and Poland.
This systematic review evaluated regional analgesic techniques for post-thoracotomy pain management, including thoracic epidural, paravertebral block, intrathecal, intercostal, and interpleural methods. The review found that continuous paravertebral block provided analgesia comparable to thoracic epidural with fewer side effects. Paravertebral block also reduced pulmonary complications versus systemic opioids, though epidural did not. Epidural was superior to intrathecal or intercostal techniques, which were still better than systemic opioids. Interpleural analgesia was inadequate. The review concluded that either epidural with local anesthetic plus opioid or continuous paravertebral block with local anesthetic can be recommended, with intrathecal opioid
This document summarizes the results of a study that evaluated the health care resource utilization and costs of patients with symptomatic multiple myeloma in the United Kingdom. The study found that the average total cost per treatment line was £34,296, with most costs attributed to anti-tumor drugs. The average cost per month of active treatment was £5,168. For patients receiving best supportive care after discontinuing active treatment, the average total cost was £1,444 if they progressed or £2,480 if they did not progress before death.
Three studies found that direct access to physical therapists significantly reduced waiting times for treatment compared to referral through consultants. Direct access also reduced pressure on consultant outpatient clinics by decreasing unnecessary referrals in two studies. One randomized controlled trial found slightly better patient recovery times and higher patient assessments of progress with direct access. However, most studies found no significant differences in the number of treatment sessions, recovery time, or return to work between direct access models and consultant referral models of physical therapy.
Module 4 Submodule 4. 2 Final June 2007Flavio Guzmán
The document discusses key considerations for clinicians in evaluating the results of drug clinical trials. It emphasizes the importance of critically assessing trial design, results, and whether the findings warrant changing clinical practice. Clinicians are advised to consider factors like trial methodology, potential biases, statistical/clinical significance, applicability to their patients, and safety. The document provides guidance on how to distinguish high-quality trials that produce useful results for patient care.
To Determine Preference of Shoulder Pain Management by General Physicians in ...suppubs1pubs1
Rotator cuff muscles are functionally active and provide stability to the shoulder joint and also thereby allow the full Range of Motion (ROM) by moving the head of humerus in the glenoid cavity. Any tear or fragility of the rotator cuff muscles can cause the dislocation or instability and hence damaging other muscles specially the long head of biceps muscle. The diseases related to the supraspinatus tendon are frequently linked with the long head of the biceps tendon. Other cause of chronic shoulder pain is the adhesive capsulitis with large prevalence rates of more than 5.3% in the general target population [3].
Corticosteroids for sore throat sr ma bmj 2018Mayra Serrano
This systematic review and meta-analysis found that a single low dose of corticosteroids, such as oral dexamethasone up to 10 mg, provides moderate to high quality evidence of pain relief for patients with sore throat. Patients who received corticosteroids were twice as likely to experience pain relief after 24 hours and 1.5 times more likely to have no pain at 48 hours, with no increase in serious adverse effects. The mean time to complete pain resolution was about 11 hours shorter with corticosteroids. Included trials enrolled over 1400 individuals and assessed outcomes up to 48 hours, but did not evaluate risks of repeated corticosteroid use for recurrent sore throats.
Effective strategies to monitor clinical risks using biostatistics - Pubrica.pdfPubrica
In clinical science, biostatistics services are essential for data collection, analysis, presentation, and interpretation. Epidemiology, clinical trials, population genetics, systems biology, and other disciplines all benefit from it. It aids in the evaluation of a drug's effectiveness and safety in clinical trials.
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This document discusses evidence-based practice (EBP) in healthcare. It provides several definitions of EBP from different sources that emphasize systematically using the most current and valid research findings to inform clinical decisions. EBP integrates the best available research evidence, clinical expertise, and patient values. The document stresses that EBP is important for improving patient care by keeping practitioners up-to-date on the most effective treatments. It also notes that implementing EBP requires profiling research to identify effective treatments while considering clinical judgment in individual cases.
Diagnoses from an on-line expert system for chronic pain confirmed by intra-o...Nelson Hendler
The Diagnostic Paradigm from www.MarylandClinicalDiagnostics.com is an on-line expert system, which gives diagnoses with a 96% correlation with diagnoses of Johns Hopkins Hospital doctors. To further confirm the accuracy of the Diagnostic Paradigm, a professor of neurosurgery from the University of Rome found 100% of the time, his intra-operative findings confirmed the diagnoses of the Diagnostic Paradigm. The Diagnostic Paradigm can be used to get pre-authorization for surgery from insurance companies, since it documents medical necessity
The document discusses a study that assessed anxiety levels in 18 healthy volunteers undergoing functional magnetic resonance imaging (fMRI). Volunteers completed the State-Trait Anxiety Inventory (STAI) before and after undergoing an fMRI examination involving six paradigms. A patient preparation phase including psychological support was provided prior to reduce anxiety. Results showed high trait and state anxiety levels pre-fMRI that significantly decreased post-fMRI. Correlations were found between pre-fMRI anxiety and brain activation in motor and language tasks. The results support incorporating patient preparation including psychological support to help reduce anxiety for fMRI examinations.
The document summarizes an evidence based project presentation on negative pressure wound therapy (NPWT) for diabetic foot ulcers (DFU). It includes objectives of the presentation, background information on evidence based nursing practice and DFUs. It also outlines the research question comparing NPWT to standard moist wound therapy for healing diabetic foot ulcers over 60 days. A literature review was conducted and findings from 5 systematic reviews showing NPWT increases healing rates for DFUs are summarized. National guidelines also support the use of NPWT for DFUs.
This qualitative study examined the unintentional induction of nocebo phenomenon (NP) through doctor-patient communication among surgeons and anesthetists. The study found that NP occurred frequently in interactions and was associated with female doctors, residents, and those with less experience (<5 years). None of the doctors were aware of the concept of NP despite acknowledging their words could impact patient well-being. The study concluded NP exists in clinical practice and awareness should be raised to avoid nocebo words and educate professionals on their negative effects.
- Vision therapy is effective in treating various visual dysfunctions related to problems with accommodation, vergence, and eye teaming.
- Numerous controlled studies have found that vision therapy improves vergence ability, eliminates symptoms of convergence insufficiency in 73-93% of patients, and is more effective than other treatments like surgery for intermittent exotropia.
- Vision therapy has also been shown to be as effective as tutoring in improving reading performance while also eliminating asthenopia, and to be effective in treating accommodative anomalies by normalizing accommodative function and reducing symptoms.
Osteoarthritis: Structural Endpoints for the Development of Drugs, Devices, a...OARSI
The document discusses considerations for developing medical products to treat osteoarthritis (OA) using structural endpoints. It notes that while modifying disease pathophysiology and changing the natural course of OA is desirable, there are challenges to reliably assessing a product's ability to alter disease progression. Specifically, there is a lack of standard definitions for progression and validated endpoints. Additionally, the relationship between structural changes and symptoms/function is variable. The document advises that substantial evidence would be needed to accept a structural endpoint for accelerated approval and reliably predict clinical benefits like reduced pain and increased function. The ultimate goal is to avoid joint failure and replacement while preserving function and relieving pain.
Chu et al. (2015)
The study reviewed 14 clinical studies that used quantitative sensory testing to detect hyperalgesia in chronic pain patients on long-term opioids. Most sensory modalities tested, including cold, heat, pressure, electrical, ischemic, and injection pain, failed to demonstrate hypersensitivity to test stimuli. Heat pain sensitivity showed some promising results in detecting hyperalgesia, but none of the measures reviewed met the criteria as a definitive standard. Additional studies with improved designs are needed.
This document discusses evidence-based practice (EBP) in healthcare. It provides several definitions of EBP, emphasizing that EBP involves integrating the best available research evidence with clinical expertise and patient values. The document notes that EBP helps ensure patients receive the best possible care, can help keep clinical knowledge up to date, and may improve outcomes and save lives. It highlights that implementing EBP involves profiling research on effective treatments to guide clinical decision making. Examples of research on effective treatments for neck pain, low back pain, and physiotherapy techniques for low back pain are also provided.
This randomized clinical trial tested an intervention using interactive voice response (IVR) technology to provide tailored behavioral support to improve statin medication adherence. The trial involved 497 patients from a large health plan who were randomized to an experimental group receiving up to 3 tailored IVR calls and printed materials, or a control group receiving a single generic IVR call and generic printed materials. The primary outcome was 6-month statin adherence based on pharmacy claims. Patients in the experimental group had significantly higher adherence (70.4%) than controls (60.7%), suggesting tailored behavioral support using IVR can effectively improve statin medication adherence.
Similar to Meta analysis of clinical efficacy of pulsed radio frequency (20)
The Pressure Right wrist strip measures 5.5 inches long by 1 inch wide and has a hard plastic button 1.5 inches from the end that is 0.52 inches in diameter and 0.27 inches high. It is made of low-density perforated polyethylene film with an acrylate adhesive and the plastic button is made of medical-grade acrylonitrile butadiene styrene plastic through an injection molding process.
The Pressure Right wrist strip is designed to apply targeted pressure to the P6 acupressure point on the wrist to help reduce nausea and vomiting. It uses an adhesive backing to keep the plastic dome firmly placed over the P6 point for an extended period, providing relief without medication. The strip is applied using a locator guide to identify the P6 point on both wrists. Placing the plastic dome over the marked points and securing the adhesive strip helps stimulate the P6 point within five minutes to alleviate nausea and vomiting associated with conditions like surgery, chemotherapy, or motion sickness.
The NEUROMOVE is a neurological rehabilitation tool that has been proven to help patients recover lost movement from strokes and other conditions. It works by training healthy neurons to assume the functions of damaged brain cells through a concept called neuroplasticity. The device can be used even without muscle movement and is suitable both for clinical use and for patients to use at home for 30 minutes a day over 4-5 months to provide dramatic recovery results.
Zmpczm0170001003 ZMPCZM017000.10.03 Neuromove clinical presentation from Pain...Painezee Specialist
The NeuroMove is an EMG-triggered neuromuscular relearning device that uses electrical stimulation to reinforce attempted movements in patients with stroke, traumatic brain injury, spinal cord injury, and other neurological conditions. It detects muscle activity through electrodes and provides electrical stimulation as a reward when activity surpasses a threshold, helping to retrain motor control through neuroplasticity. Clinical studies have found the NeuroMove effective in regaining function for chronic stroke patients by improving proprioceptive feedback through activity time-locked to movement attempts.
ZMPCZM017000.10.03 Neuromove clinical presentation from PainEzeePainezee Specialist
The NeuroMove is an EMG-triggered neuromuscular relearning device that uses electrical stimulation to reinforce attempted movements in patients with stroke, traumatic brain injury, spinal cord injury, and other neurological conditions. It detects muscle activity through electrodes and provides electrical stimulation as a reward when activity crosses a threshold, helping to retrain motor control pathways in the brain. Clinical studies have found the NeuroMove effective in regaining function for chronic stroke patients by improving proprioceptive feedback through intensive, repetitive therapy sessions using this brain retraining tool.
ZMPCZM017000.10.03 Neuromove clinical presentation from PainEzeePainezee Specialist
The NeuroMove is an EMG-triggered neuromuscular relearning device that uses electrical stimulation to reinforce attempted movements in patients with stroke, traumatic brain injury, spinal cord injury, and other neurological conditions. It detects muscle activity through electrodes and provides electrical stimulation as a reward when activity crosses a threshold, helping to retrain motor control pathways in the brain. Clinical studies have found the NeuroMove effective in regaining function for chronic stroke patients by improving proprioceptive feedback through intensive, repetitive therapy sessions using this brain retraining tool.
The document summarizes the features and benefits of the MY TENS device, which is designed for home use transcutaneous electrical nerve stimulation (TENS) therapy. Key points:
- MY TENS is certified for safety and designed for easy home use without complicated settings. It provides a preset operating program to effectively treat most pain conditions.
- The device has an ergonomic design that allows for simple, flexible application to any part of the body. It also ensures the electrical signal is transmitted intact from the device to the patient.
- MY TENS can be discreetly used in public as it can be placed under clothes. It is also affordable and reusable through replacement of consumable parts.
This document declares that the NexWave Combo Muscle Stimulator and similar products manufactured for other distributors meet the essential health and safety requirements of the European Community. The manufacturer, Zynex Medical, Inc., used conformity assessment procedures and standards including ISO 13485 for quality management, IEC 60601 for electrical safety of medical equipment, and EN 1041 for information supplied by manufacturers. Thomas Sandgaard, President and CEO of Zynex Medical, Inc., signed the declaration on November 18, 2011.
This document provides instructions for electrode placement for various neuromuscular electrical stimulation (NMES) treatments. It describes the patient positioning and placement of the red and black electrodes on the body for treatments targeting the biceps, triceps, elbow flexion, elbow extension, wrist and finger flexion, shoulder abduction, and ankle dorsiflexion. Electrode placement may require trial and error to find the correct spots using low level stimulation. Additional targeted muscle groups and placements are described in the user manual.
Zywie Medical Devices Private Limited has commenced a collaboration with the Medical Devices Division of Juno Pharm from October 13, 2013. This collaboration will help both companies capture their full potential and help expand their business footprint in pain management medical devices across India. Ms. Chavali Anilaja announced the collaboration.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against developing mental illness and improve symptoms for those who already suffer from conditions like anxiety and depression.
This document provides instructions for connecting electrodes for a TENS (transcutaneous electrical nerve stimulation) unit. It notes that the unit has two lead wires that should be connected to opposite electrodes in a diagonal configuration as shown in the diagram, and that the lead wire colors do not matter as long as the connections are diagonal.
This document provides instructions for proper electrode placement for a TENS (transcutaneous electrical nerve stimulation) unit. It notes that the unit has two lead wires that should be connected to opposite electrodes in a diagonal configuration as shown in the included diagram. The document also specifies that the lead wire colors do not matter and can be placed on either the top or bottom of the area being treated.
1. This document provides instructions for using NeuroGraph software to conduct biofeedback sessions. It describes how to select a patient, choose a protocol, attach sensors, monitor signals in real-time, set goals and provide feedback.
2. The user's guide explains how to review session data, including graph displays, replay functions, and report generation. Customization options allow modifying graph types, colors, and other display settings.
3. Advanced features include creating schedules with multiple trials, setting trial properties, and exporting data. The guide provides details on protocol customization, system settings, and other administrative functions for configuring and managing NeuroGraph software.
This document provides a user's guide for NeuroGames software. It describes how to install and set up the software, select protocols, create and edit protocols, manage patients, run protocols, view reports and save session data. Key steps include checking the instrument settings, selecting or creating a protocol, selecting a patient, running the protocol, and viewing saved session reports. The guide also describes options for password protection, confidentiality settings, and alternative protocol types including jungle and star light games.
The document provides an overview and instructions for using the IncontiMed Checklist software. It describes how to select a patient, administer a checklist to collect patient responses, generate reports on completed checklists, and manage patient records and settings. The software is designed to collect self-reported information from patients on incontinence experiences and supports customization of report templates, password protection, and displaying initials instead of names for patient confidentiality.
The document provides an overview and instructions for using the Headache Checklist software. It describes how to select a patient, administer the checklist questions, generate reports, and manage patient records and settings. The software allows clinicians to collect self-reported headache information from patients and create standardized reports in a HIPAA-compliant manner. It can be used as an assessment tool alongside a clinical evaluation to help evaluate headache complaints.
This document provides instructions for using ChiroScan software to conduct electromyography (EMG) scans. It describes connecting hardware, installing and registering the software, configuring instruments and protocols, and conducting scanning procedures. The scanning procedure involves preparing the skin, applying sensors coated with electrode gel to specific sites on the back, and collecting EMG data to measure muscle activity levels. The software analyzes the data and can generate reports comparing results to normative values.
This document contains information about dermatome charts, peripheral nerve charts, and motor point locations for electrostimulation therapy. The dermatome charts show the cutaneous nerve innervation patterns for the front, back, and foot. The peripheral nerve charts display the branches of the cervical, brachial, lumbar, and sacral plexuses. The motor point sections provide diagrams of the anterior and posterior muscle motor points for the trunk, upper extremities, and lower extremities.
There are two types of nerve fibers that transmit signals from the body to the brain. Large nerve fibers called nociceptive fibers do not transmit pain signals, while small nerve fibers do transmit pain signals. A TENS unit works by using electrical currents to stimulate the large nerve fibers, which prevents the small pain fibers from reaching the brain. This stimulation of large fibers closes the "gate" in the spinal cord to pain signals from the small fibers, providing pain relief. This mechanism is known as the "gate control theory of pain."
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system