The document outlines the surgical approach to resect mediastinal tumors based on their anatomical location within the mediastinum, which is divided into superior and inferior sections, with the latter further partitioned into anterior, middle, and posterior regions. It details the contents of each mediastinal section and the various surgical techniques employed, including median sternotomy, thoracotomy, and robotic-assisted methods. The use of video-assisted thoracoscopic surgery (vats) and robotic-assisted thoracic surgery (rats) is increasingly common, particularly for anterior mediastinal tumors like thymomas.