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DEPARTMENT OF ENGINEERING SCIENCE
INSTITUTE OF BIOMEDICAL ENGINEERING
CENTRE FOR DOCTORAL TRAINING IN HEALTHCARE INNOVATION
July 23, 2014
FROM QUESTIONNAIRES TO
OBJECTIVE DATA
CONTINUOUS MONITORING OF MANIA AND
DEPRESSION SYMPTOMS USING MOBILE
PHONE SENSORS
Maxim Osipov
supervised by Prof. Gari Clifford
and Dr. David Clifton
Problem
* WHO. The global burden of disease: 2004 update.
Symptoms
Dimensions of
Psychopathology*
Reality distortion
Hallucinations, Delusions
Poverty
Flat affect, Poverty
of speech*,
Decreased
voluntary motor
activity*
Depression
Low mood, Low self-
esteem,
Hopelessness,
Suicidality, Somatic
symptoms*
Disorganization
Formal thought disorder,
Inappropriate affect, Disorganized
or bizarre behavior*
Anxiety
Feelings of unease, fear* or dread,
Overactivity of the sympathetic nervous
system*
* Symptoms can be detected
using activity, cardiovascular or
electrodermal monitoring
Psychomotor
Excitation
Labile affect,
Pressure of
speech*,
Motor agitation*
Mood
Elation
Elevated mood,
Elevated self-
esteem, Decreased
need for sleep*
* P. F. Liddle, Disordered mind and brain: The neural basis of mental symptoms.
Bipolar disorder
Bipolar Disorder
Lifetime prevalence of ~1.5%
Peak age of first episode onset
is in the teens or twenties
20x increase in risk of suicide
“Cyclical” illness, ~10% have 4
or more episodes per year
* DSM-IV
Management
Medication to prevent episodes
of mania and depression
Medication to treat the main
symptoms
Psychological treatment
Detecting warning signs helps
with better treatment
Bipolar disorder - Management
Depression and Mania (QIDS & ASRM)
1. Falling Asleep *
2. Sleep During the Night *
3. Waking Up Too Early *
4. Sleeping Too Much *
5. Feeling Sad
6,7. Increased / Decreased Appetite
8,9. Increased / Decreased Weight
10. Concentration / Decision Making
11. View of Myself
12. Thoughts of Death or Suicide
13. General Interest
14. Energy Level *
15. Feeling Slowed Down *
16. Feeling Restless *
1. Happiness
2. Self-confidence
3. Need for Sleep *
4. Talk More *
5. Being More Active *
* Can be measured objectively, using mobile or wearable devices.
Automated Monitoring of Symptom
Severity (AmoSS) – PI Prof. Gari Clifford
Physical activity
Light exposure
Battery level
Geolocation
Mobile phone data limitations
Integration with self-management platform
Acknowledgments
Hill Foundation Scholarship
RCUK Digital Economy Programme grant number EP/G036861/1
(Oxford Centre for Doctoral Training in Healthcare Innovation)
Wellcome Trust Centre Grant No. 098461/Z/12/Z (Sleep, Circadian
Rhythms and Neuroscience Institute)
EPSRC grant EP/K020161/1 (Multiscale markers of circadian rhythm
changes for monitoring of mental health)
Acknowledgments - AmoSS Team
Prof. Gari Clifford
Prof. Guy Goodwin
Dr. Athanasios Tsanas
Dr. Amy Bilderbeck
Dr. Kate Saunders
Niclas Palmius
Thank you!

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Maxim Osipov - Big Data in Mental Health - 23rd July 2014

  • 1. DEPARTMENT OF ENGINEERING SCIENCE INSTITUTE OF BIOMEDICAL ENGINEERING CENTRE FOR DOCTORAL TRAINING IN HEALTHCARE INNOVATION July 23, 2014 FROM QUESTIONNAIRES TO OBJECTIVE DATA CONTINUOUS MONITORING OF MANIA AND DEPRESSION SYMPTOMS USING MOBILE PHONE SENSORS Maxim Osipov supervised by Prof. Gari Clifford and Dr. David Clifton
  • 2. Problem * WHO. The global burden of disease: 2004 update.
  • 3. Symptoms Dimensions of Psychopathology* Reality distortion Hallucinations, Delusions Poverty Flat affect, Poverty of speech*, Decreased voluntary motor activity* Depression Low mood, Low self- esteem, Hopelessness, Suicidality, Somatic symptoms* Disorganization Formal thought disorder, Inappropriate affect, Disorganized or bizarre behavior* Anxiety Feelings of unease, fear* or dread, Overactivity of the sympathetic nervous system* * Symptoms can be detected using activity, cardiovascular or electrodermal monitoring Psychomotor Excitation Labile affect, Pressure of speech*, Motor agitation* Mood Elation Elevated mood, Elevated self- esteem, Decreased need for sleep* * P. F. Liddle, Disordered mind and brain: The neural basis of mental symptoms.
  • 4. Bipolar disorder Bipolar Disorder Lifetime prevalence of ~1.5% Peak age of first episode onset is in the teens or twenties 20x increase in risk of suicide “Cyclical” illness, ~10% have 4 or more episodes per year * DSM-IV Management Medication to prevent episodes of mania and depression Medication to treat the main symptoms Psychological treatment Detecting warning signs helps with better treatment
  • 5. Bipolar disorder - Management
  • 6. Depression and Mania (QIDS & ASRM) 1. Falling Asleep * 2. Sleep During the Night * 3. Waking Up Too Early * 4. Sleeping Too Much * 5. Feeling Sad 6,7. Increased / Decreased Appetite 8,9. Increased / Decreased Weight 10. Concentration / Decision Making 11. View of Myself 12. Thoughts of Death or Suicide 13. General Interest 14. Energy Level * 15. Feeling Slowed Down * 16. Feeling Restless * 1. Happiness 2. Self-confidence 3. Need for Sleep * 4. Talk More * 5. Being More Active * * Can be measured objectively, using mobile or wearable devices.
  • 7. Automated Monitoring of Symptom Severity (AmoSS) – PI Prof. Gari Clifford
  • 12. Mobile phone data limitations
  • 14. Acknowledgments Hill Foundation Scholarship RCUK Digital Economy Programme grant number EP/G036861/1 (Oxford Centre for Doctoral Training in Healthcare Innovation) Wellcome Trust Centre Grant No. 098461/Z/12/Z (Sleep, Circadian Rhythms and Neuroscience Institute) EPSRC grant EP/K020161/1 (Multiscale markers of circadian rhythm changes for monitoring of mental health)
  • 15. Acknowledgments - AmoSS Team Prof. Gari Clifford Prof. Guy Goodwin Dr. Athanasios Tsanas Dr. Amy Bilderbeck Dr. Kate Saunders Niclas Palmius