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4
                                                   Antepartum
                                                   haemorrhage

Before you begin this unit, please take the        ANTEPARTUM
corresponding test at the end of the book to
assess your knowledge of the subject matter. You   HAEMORRHAGE
should redo the test after you’ve worked through
the unit, to evaluate what you have learned.
                                                   4-1 What is an antepartum haemorrhage?
                                                   An antepartum haemorrhage is any vaginal
 Objectives                                        bleeding which occurs at or after 24 weeks
                                                   (estimated fetal weight at 24 weeks = 500 g) and
                                                   before the birth of the infant. A bleed before 28
 When you have completed this unit you
                                                   weeks is regarded as a threatened miscarriage as
 should be able to:                                the fetus is usually considered not to be viable.
 • Understand why an antepartum
   haemorrhage should always be regarded             NOTE  A fetus is viable from 28 weeks, or an
                                                     estimated weight of 1000 g, if the duration
   as serious.
                                                     of pregnancy is uncertain. Antepartum
 • Provide the initial management of a               haemorrhage before the fetus is viable has
   patient presenting with an antepartum             the same serious complications as that with a
   haemorrhage.                                      viable fetus. In both cases, the management
                                                     is the same except for fetal monitoring, which
 • Understand that it is sometimes                   is only done from 28 weeks (or 1000 g).
   necessary to deliver the fetus as soon as
   possible, in order to save the life of the      4-2 Why is an antepartum haemorrhage
   mother or infant.                               such a serious condition?
 • Diagnose the cause of the bleeding              1. The bleeding can be so severe that it can
   from the history and examination of the            endanger the life of both the mother and
   patient.                                           fetus.
 • Correctly manage each of the causes of          2. Abruptio placentae is a common cause
   antepartum haemorrhage.                            of antepartum haemorrhage and an
                                                      important cause of perinatal death in
 • Diagnose the cause of a blood-stained
                                                      many communities.
   vaginal discharge and administer
   appropriate treatment.                          Therefore, all patients who present with an
                                                   antepartum haemorrhage must be regarded as
ANTEPAR TUM HAEMORRHAGE       101


serious emergencies until a diagnosis has been       2. Assess the condition of the fetus. If the
made. Further management will depend on                 fetus is viable but distressed, an emergency
the cause of the haemorrhage.                           delivery is needed.
                                                     3. Diagnose the cause of the bleeding,
                                                        taking the clinical findings into account
 Any vaginal bleeding during pregnancy may be           and, if necessary, the results of special
 an important danger sign that must be reported         investigations.
 immediately.
                                                     The initial management and diagnosis of a
                                                     patient with vaginal bleeding is summarised in
4-3 What advice about vaginal bleeding               Flow diagram 4-1.
should you give to all patients?
Every patient must be advised that any vaginal       4-5 What symptoms and signs indicate that
bleeding is potentially serious and told that this   the patient is shocked due to blood loss?
complication must be reported immediately.
                                                     1. Dizziness is the commonest symptom of
                                                        shock.
4-4 What is the management of                        2. On general examination the patient
an antepartum haemorrhage?                              is sweating, her skin and mucous
The management consists of four important               membranes are pale, and she feels cold
steps that should be carried out in the                 and clammy to the touch.
following order:                                     3. The blood pressure is low and the pulse
                                                        rate fast.
1. The maternal condition must be evaluated
   and stabilised, if necessary.
                                                     4-6 How should you manage a shocked
2. The condition of the fetus must then be
                                                     patient with an antepartum haemorrhage?
   assessed.
3. The cause of the haemorrhage must be              When there are symptoms and signs to
   diagnosed.                                        indicate that the patient is shocked, you must:
4. Finally, the definitive management of an
                                                     1. Put up two intravenous infusions (‘drips’)
   antepartum haemorrhage, depending on
                                                        with Balsol or Ringer’s lactate, to run in
   the cause, must be given.
                                                        quickly in order to actively resuscitate the
It must also be decided whether the patient             patient.
should be transferred for further treatment.         2. Insert a Foley catheter into the patient’s
                                                        bladder to measure the urinary volume
                                                        and to monitor further urine output.
THE INITIAL EMERGENCY                                3. If blood is available, take blood for cross-
                                                        matching at the time of putting up the
MANAGEMENT                                              intravenous infusion and order two or
OF ANTEPARTUM                                           more units of blood urgently.
                                                     4. Listen to the fetal heart:
HAEMORRHAGE                                             • If fetal distress is present and the fetus
                                                            is assessed to be viable (28 weeks or an
The management must always be provided in                   estimated weight of 1000 g or more),
the following order:                                        then deliver by the quickest possible
1. Assess the condition of the patient. If the              method, usually by Caesarean section.
   patient is shocked, she must be resuscitated         • If fetal distress is excluded, if the fetus
   immediately.                                             is too preterm to be viable, or if there
                                                            is an intra-uterine death, then more
                                                            attention can be given to the history
102   MATERNAL CARE




            History of
             vaginal                  Maternal condition?             Not shocked
            bleeding




              Resuscitate                  Shocked




                                 No                         Yes
            A life-threatening                                     Refer for urgent
             haemorrhage?               Fetal stress?                 delivery



                         Yes                       No


           Refer for urgent              What type of               Antepartum                Speculum
           Caesarean section               bleed?                  haemorrhage               examination




                                      Blood mixed with                                         No local
                                      mucus, or blood-            Local cause, eg.
                                                                                                cause
                                      stained discharge           vaginitis or local
                                                                                                found
                                                                       lesion




                                                                     Treat local       Decide between:
                                           ‘Show’ or                                   1. Placenta praevia
                                           vaginitis                  cause of
                                                                      bleeding         2. Abruptio placentae
                                                                                         and refer




Flow diagram 4-1: Initial management of a patient with vaginal bleeding
ANTEPAR TUM HAEMORRHAGE           103


       and examination of the patient in          If the maternal and fetal conditions are
       order to make a diagnosis of the cause     satisfactory, then a careful speculum
       of the bleeding.                           examination should be done to exclude a
                                                  local cause of the bleeding. Do not perform a
4-7 What must you do if a patient presents        digital vaginal examination, as this may cause
with a life-threatening haemorrhage?              a massive haemorrhage if the patient has a
                                                  placenta praevia.
The maternal condition takes preference
over that of the fetus. The patient, therefore,
is actively resuscitated while arrangements        Do not do a digital vaginal examination until
are made to terminate the pregnancy by             placenta praevia has been excluded.
Caesarean section.
                                                  4-9 How does a speculum examination help
                                                  you determine the cause of the bleeding?
DIAGNOSING THE CAUSE
                                                  1. Bleeding through a closed cervical os
OF THE BLEEDING                                      confirms the diagnosis of a haemorrhage.
                                                  2. If the cervix is a few centimetres dilated
                                                     with bulging membranes, or the presenting
4-8 Should you treat all patients                    part of the fetus is visible, this suggests that
with antepartum haemorrhage in                       the bleed was a ‘show’.
the same way, irrespective of the                 3. A blood-stained discharge in the vagina,
amount and character of the bleed?                   with no bleeding through the cervical os,
No. The management differs depending on              suggests a vaginitis.
whether the vaginal bleeding is diagnosed         4. Bleeding from the surface of the cervix
as a ‘haemorrhage’ on the one hand, or a             caused by contact with the speculum (i.e.
blood-stained vaginal discharge or a ‘show’          contact bleeding) may indicate a cervicitis
on the other hand. A careful assessment of           or cervical intra-epithelial neoplasia (CIN).
the amount and type of bleeding is, therefore,    5. Bleeding from a cervical tumour or
very important.                                      an ulcer may indicate an infiltrating
                                                     carcinoma.
1. Any vaginal bleeding at or after 24 weeks
   must be diagnosed as an antepartum
   haemorrhage if any of the following are        4-10 Can you rely on clinical findings to
   present:                                       determine the cause of a haemorrhage?
   • A sanitary pad is at least partially         In many cases the history and examination of
      soaked with blood.                          the abdomen will enable the patient to be put
   • Blood runs down the patient’s legs.          into one of two groups:
   • A clot of blood has been passed.
                                                  1. Abruptio placentae.
A diagnosis of a haemorrhage always suggests      2. Placenta praevia.
a serious complication.
                                                  There are some patients in whom no reason
1. A blood-stained vaginal discharge will         for the haemorrhage can be found. Such a
   consist of a discharge mixed with a small      haemorrhage is classified as an antepartum
   amount of blood.                               haemorrhage of unknown cause.
2. A ‘show’ will consist of a small amount
   of blood mixed with mucus. The blood-
   stained vaginal discharge or ‘show’ will be
   present on the surface of the sanitary pad
   but will not soak it.
104   MATERNAL CARE



4-11 What is the most likely cause                       of the other hypertensive disorders of
of an antepartum haemorrhage                             pregnancy.
with fetal distress?                                3.   Intra-uterine growth restriction.
                                                    4.   Cigarette smoking.
Abruptio placentae is the commonest cause
                                                    5.   Poor socio-economic conditions.
of antepartum haemorrhage leading to fetal
                                                    6.   A history of abdominal trauma, e.g. a fall
distress. However, sometimes there may be
                                                         or kick on the abdomen.
very little or no bleeding even with a severe
abruptio placentae.
                                                    4-15 What symptoms point to a
                                                    diagnosis of abruptio placentae?
 An antepartum haemorrhage with fetal distress
                                                    1. An antepartum haemorrhage which
 or fetal death is almost always due to abruptio
                                                       is associated with continuous severe
 placentae.                                            abdominal pain.
                                                    2. A history that the blood is dark red with
4-12 What is the most likely cause of a life-          clots.
threatening antepartum haemorrhage?                 3. Absence of fetal movements following the
                                                       bleeding.
A placenta praevia is the most likely cause
of a massive antepartum haemorrhage that
threatens the patient’s life.                       4-16 What do you expect to find
                                                    on examination of the patient?
                                                    1. The general examination and observations
ANTEPARTUM BLEEDING                                    show that the patient is shocked, often
CAUSED BY ABRUPTIO                                     out of proportion to the amount of visible
                                                       blood loss.
PLACENTAE                                           2. The patient usually has severe abdominal
                                                       pain.
                                                    3. The abdominal examination shows the
4-13 What is abruptio placentae?                       following:
Abruptio placentae (placental abruption)               • The uterus is tonically contracted, hard
means that part or all of the normally                     and tender, so much so that the whole
implanted placenta has separated from the                  abdomen may be rigid.
uterus before delivery of the fetus. The cause of      • Fetal parts cannot be palpated.
abruptio placentae remains unknown.                    • The uterus is bigger than the patient’s
                                                           dates suggest.
                                                       • The haemoglobin concentration is low,
4-14 Which patients are at increased
                                                           indicating severe blood loss.
risk of abruptio placentae?
                                                    4. The fetal heartbeat is almost always absent
Patients with:                                         in a severe abruptio placentae.
1. A history of an abruptio placentae in a          These symptoms and signs are typical of a
   previous pregnancy. (There is a 10% chance       severe abruptio placentae. However, abruptio
   of recurrence after an abruptio placentae        placentae may present with symptoms and
   in a previous pregnancy and a 25% chance         signs which are less obvious, making the
   after two previous pregnancies with an           diagnosis difficult.
   abruptio placentae.)
                                                    The management of abruptio placentae is
2. Pre-eclampsia (gestational proteinuric
                                                    summarised in flow diagram 4-2.
   hypertension) and, to a lesser extent, any
ANTEPAR TUM HAEMORRHAGE     105




                                           Antepartum
                                        haemmorhage with
                                       symptoms or signs of
                                        abruptio placentae




         Shocked                  Maternal condition?                Not shocked




                                      Fetal heart         No         Rupture
       Resuscitate                                                                   Vaginal delivery
                                       present?                     membranes

                                            Yes


                        Yes                                    No
         Vaginal
                                     Fetus viable?
       examination




      Cervix 9 cm or
     more dliated and     No          Caesarean
        fetal head                     section
       engaged?

               Yes



         Vaginal
         delivery




Flow diagram 4-2: Management of a patient with an abruptio placentae
106   MATERNAL CARE



                                                     4-19 What should you do if the
 The diagnosis of severe abruptio placentae can
                                                     fetal heartbeat is absent?
 usually be made from the history and physical
 examination.                                        1. Active resuscitation of the mother is a
                                                        priority and should have been started as
                                                        part of the initial emergency management:
4-17 What would you do if the fetal
                                                        • Two intravenous infusion lines are
heartbeat was still present?
                                                            usually needed, one of which can be a
If the fetal heartbeat is still present with an             central venous pressure line inserted in
abruptio placentae, there will usually be signs             the antecubital fossa.
of fetal distress. The infant will die in utero if      • Two units of fresh frozen plasma,
not delivered immediately.                                  and at least four units of whole blood
                                                            are usually needed for effective
4-18 How should you decide on                               resuscitation.
the method of delivery if the fetal                  2. A Foley catheter is inserted into the
heartbeat is still present?                             bladder.
                                                     3. The pulse rate and blood pressure must
1. If the symptoms and signs are typical of an          be checked every 15 minutes until the
   abruptio placentae, a vaginal examination            patient’s condition stabilises, and half-
   should be done.                                      hourly thereafter. The urinary output must
2. If the cervix is at least 9 cm dilated, and the      be recorded hourly.
   presenting part is well down in the pelvis,       4. The membranes are then ruptured,
   then the membranes should be ruptured                following which cervical dilatation and
   and the infant delivered vaginally. If these         delivery of the fetus usually occur quickly.
   conditions are not present, an emergency          5. Pain relief in the form of pethidine or
   Caesarean section should be done.                    morphine and promethazine (Phenegan)
3. If the fetus is not viable, it should be             or hydroxyzine (Aterax) should be given
   delivered vaginally if the diagnosis is              once the patient is adequately resuscitated.
   abruptio placentae.
4. While preparations for delivery are being
                                                     4-20 Why is it important to remember that
   made, the mother must be resuscitated
                                                     many patients with abruptio placentae
   and intra-uterine resuscitation of the fetus
                                                     have underlying pre-eclampsia?
   started. However, salbutamol or nifedipine
   must not be given to a patient who shows          1. Signs of shock may be present even with
   any evidence of shock.                               a normal blood pressure. These patients,
5. When there is doubt about the diagnosis,             nevertheless, need active resuscitation.
   specifically when placenta praevia cannot         2. After resuscitation a hypotensive patient
   be excluded on history and examination,              may become hypertensive, so much so that
   then a digital vaginal examination should            dihydralazine (Nepresol) may have to be
   not be done. If fetal distress is present and        given parenterally or nifedipine (Adalat)
   the fetus is viable, a Caesarean section             orally.
   must be done. If there is neither fetal           3. Magnesium sulphate must be given if the
   distress nor severe vaginal bleeding, the            patient develops imminent eclampsia.
   possibility of a placenta praevia must be
   investigated. An ultrasound examination             NOTE  These patients are haemodynamically very
   or vaginal examination in theatre must              unstable. Although initially they also require
                                                       active resuscitation, they quickly become
   then be done.
                                                       fluid overloaded, resulting in pulmonary
                                                       oedema. Renal complications, such as
                                                       acute tubular necrosis, commonly occur.
ANTEPAR TUM HAEMORRHAGE       107


4-21 At your initial assessment of                       •   Are grande multiparas, i.e. who are
the patient, how would you know                              para 5 or higher.
whether or not there is underlying                       • Have had a previous Caesarean section.
pre-eclampsia present?                                2. With regard to their present obstetric
                                                         history, patients who:
By finding protein in the patient’s urine.
                                                         • Have a multiple pregnancy.
                                                         • Have had a threatened abortion,
 Abruptio placentae with pre-eclampsia is a serious          especially in the second trimester.
 condition with a high risk of maternal death.           • Have an abnormal presentation.


4-22 What complication should                         4-26 What in the history of the bleeding
you watch for after delivery?                         suggests the diagnosis of placenta praevia?

Postpartum haemorrhage, as this is common             1. The bleeding is painless and bright red in
after abruptio placentae.                                colour.
                                                      2. Fetal movements are still present after the
                                                         bleed.
4-23 What action should you take to
prevent postpartum haemorrhage?
                                                      4-27 What are the typical findings
1. Syntometrine 1 ampoule should be given             on physical examination in a
   intramuscularly, if the patient is not             patient with placenta praevia?
   hypertensive. Only oxytocin is used in a
   hypertensive patient.                              1. General examination may show signs that
2. In addition, 20 units of oxytocin are put in          the patient is shocked, and the amount
   the intravenous infusion bottle.                      of bleeding corresponds to the degree
3. The uterus is rubbed up well.                         of shock. The patient’s haemoglobin
4. The patient is carefully observed for                 concentration is normal or low depending
   bleeding.                                             on the amount of blood loss and the time
                                                         interval between the haemorrhage and the
                                                         haemoglobin measurement. However, the
ANTEPARTUM                                               first bleed is usually not severe.
                                                      2. Examination of the abdomen shows that:
BLEEDING CAUSED BY                                       • The uterus is soft and not tender to
PLACENTA PRAEVIA                                             palpation.
                                                         • The uterus is not bigger than it should
                                                             be for the patient’s dates.
4-24 What is placenta praevia?                           • The fetal parts can be easily palpated,
                                                             and the fetal heart is present.
Placenta praevia means that the placenta is
                                                         • There may be an abnormal
implanted either wholly or partially in the lower
                                                             presentation. Breech presentation or
segment of the uterus. It may extend down to,
                                                             oblique or transverse lies are commonly
or cover the internal os of the cervix. When
                                                             present.
the lower segment starts to form or the cervix
                                                         • In cephalic presentations, the head is
begins to dilate, the placenta becomes partially
                                                             not engaged and is easily balottable
separated and this causes maternal bleeding.
                                                             above the pelvis.
4-25 Which patients have the
highest risk of placenta praevia?                      The diagnosis of placenta praevia can usually be
1. With regard to their previous obstetric
                                                       made from the history and physical examination.
   history, patients who:
108   MATERNAL CARE



4-28 Do you think that engagement                    4-32 What is the further management after
of the head can occur if there is                    making the diagnosis of placenta praevia?
a placenta praevia present?
                                                     1. If the patient is not bleeding actively,
No. If there is 2/5 or less of the fetal head           further management depends on the
palpable above the pelvic brim on abdominal             gestational age:
examination, then placenta praevia can be               • With a gestational age of less than 38
excluded and a digital vaginal examination can              weeks, the patient is hospitalised and
be done safely. The first vaginal examination               managed conservatively until 38 weeks
must always be done carefully.                              or until active bleeding starts.
                                                        • If the fetus is viable (28 weeks or
                                                            more) but the gestational age is less
 Two fifths or less of the fetal head palpable              than 34 weeks, steroids must be given
 above the pelvic brim excludes the possibility of          to stimulate fetal lung maturity as
 placenta praevia.                                          delivery may become necessary within
                                                            a few days.
4-29 What do you understand                             • With a gestational age of 38 weeks or
by a ‘warning bleed’?                                       more, the fetus should be delivered.
                                                        The further management of a patient
This is the first bleeding that occurs from a           when her pregnancy has reached 36 weeks
placenta praevia, when the lower segment                depends on the grade of placenta praevia.
begins to form at about 34 weeks, or even            2. A patient who is actively bleeding must be
earlier.                                                delivered irrespective of the gestational age,
                                                        because this is a life-threatening condition
4-30 Are there any investigations that can              for the patient. An emergency Caesarean
confirm the diagnosis of placenta praevia?              section or hysterotomy must be done.
1. If the patient is less than 38 weeks pregnant     The management of a patient with a placenta
   and not bleeding actively, an ultrasound          praevia is summarised in flow diagrams 4-3
   examination must be done in order to              and 4-4.
   localise the placenta.
2. If the patient is 38 or more weeks pregnant,      4-33 When a patient with placenta
   and not bleeding actively:                        praevia is less than 38 weeks pregnant
   • If ultrasonology is available, an               and is being managed conservatively,
       ultrasound examination can be done in         what amount of bleeding would indicate
       order to localise the placenta.               that you should deliver the fetus?
   • If ultrasonology is not available, a
       digital vaginal examination can be done       1. Any sudden, severe haemorrhage.
       in theatre with everything ready for a        2. Any continuous, moderate bleeding, such
       Caesarean section.                               that the drop in the patient’s haemoglobin
                                                        concentration requires a blood transfusion.
4-31 What action should you take if a
routine ultrasound examination early in              4-34 How will you further manage a patient
pregnancy shows a placenta praevia?                  who has been treated conservatively?
In most cases, the position of the placenta          1. With a grade 3 or 4 placenta praevia, a
moves away from the internal os of the                  Caesarean section should be done at 36
cervix as pregnancy continues. A follow-up              weeks.
ultrasound examination must be arranged at a         2. With a grade 2 placenta praevia, a
gestational age of 32 weeks.                            Caesarean section should be done at 38
                                                        weeks.
ANTEPAR TUM HAEMORRHAGE            109




               Antepartum
           haemorrhage with
                                          Maternal condition?
          symptoms or signs of
            placenta praevia




           Resuscitate                          Shocked             Not shocked




           Caesarean              Yes                              No
          section if fetus                                                                ltrasound
                                          Fetal distress?                               examination
              viable




                                            Continuing                            Yes
           Caesarean             Yes                                                          lacenta
                                          bleeding with a            ospitalise
            section                                                                          praevia?
                                             fall in b?
                                                                                                   No
                                                     No


                                                                 A of             No         ocal
               See flow                 ed rest to              unknown                    cause?
            diagram V                     weeks                  cause
                                                                                                  Yes




                                                                                           reat local cause




Flow diagram 4-3: Management of a patient with a placenta praevia before 36 weeks
110   MATERNAL CARE




                                                     lacenta praevia
                                                      of weeks
                                                        or more




                                                         rade of
                                                   placenta praevia?




           rade with                                                                           rade or
          bleeding or                    rade
                               with engaged head and                    rade of placenta        placenta
        unengaged head                                                 praevia uncertain   covering internal
          or rade                    no bleeding
                                                                                             cervical os




             ait for                   ait for                                                Caesarian
            weeks or               spontaneous                                                 section
            bleeding              onset of labour



                                 Careful vaginal
                                  examination



                                   lacental tissue
                                 palpable in lower
                                     segment?
                       Yes                                      No




          Caesarean                                       Rupture membranes
           section                                        and deliver vaginally




Flow diagram 4-4: Management of a patient with a placenta praevia at 36 weeks or more
ANTEPAR TUM HAEMORRHAGE      111


3. With a grade 1 placenta praevia which                ability as the upper segment to contract
   bleeds now, and a presenting part that               and retract after delivery. Therefore,
   remains high above the pelvis, a Caesarean           the same measures taken with abruptio
   section should be done at 38 weeks.                  placentae must be taken to prevent
4. With a grade 1 placenta praevia, which               postpartum haemorrhage.
   does not bleed and where the fetal head
   is engaged (2/5 or less palpable above the
   brim), you can wait for the spontaneous           ANTEPARTUM
   onset of labour. The first vaginal
   examination must be done very carefully.          HAEMORRHAGE OF
                                                     UNKNOWN CAUSE
4-35 How do you go about doing a
vaginal examination in theatre?
                                                     4-38 When would you suspect
1. The theatre sister must be scrubbed up            an antepartum haemorrhage
   with her trolley ready.                           of unknown cause?
2. The anaesthetist must be ready with his
   drugs drawn up so that, if necessary, he can      In patients who fulfill all the following
   proceed immediately with the induction of         requirements:
   anaesthesia.                                      1. Less severe antepartum bleeding, without
3. A careful digital examination must be                signs of shock, and when the fetal
   done. First feel in all four vaginal fornices:       condition is good.
   • If there is soft tissue between the             2. When the history and examination do not
      examining finger and the fetal skull,             suggest a severe abruptio placentae.
      then placenta praevia is diagnosed.            3. When local causes have been excluded on
   • If the fetal skull is easily felt in all four      speculum examination.
      fornices, then a careful examination is        4. When placenta praevia has been excluded
      done through the cervix.                          by an ultrasound examination.
   • If placental tissue is felt, then a
      Caesarean section should be done. If           4-39 What should you do to exclude
      not, the membranes can be ruptured             other causes of bleeding if you do
      with the aim of allowing a vaginal             not have ultrasound facilities ?
      delivery.
                                                     1. Abruptio placentae can usually be excluded
                                                        on history and examination.
4-36 If the fetus is alive, why is urgent            2. Local causes are excluded on speculum
delivery of less importance in placenta                 examination.
praevia than in abruptio placentae?                  3. With a gestational age of 38 weeks or more,
Compared with abruptio placentae, intra-                a vaginal examination is done in theatre to
uterine death is uncommon in placenta                   confirm or exclude placenta praevia.
praevia. However, a serious vaginal bleed due        4. If the gestational age is less than 38
to placenta praevia may still necessitate an            weeks, the patient must be admitted to
immediate delivery to save the mother’s life.           hospital and close attention paid to fetal
                                                        movements, especially in the first 24 hours.
4-37 Why do patients with a placenta
                                                       NOTE If available, antenatal fetal heart
praevia have an increased risk of
                                                       rate monitoring should be done on
postpartum haemorrhage?                                admission to hospital and every six
1. The placenta was implanted in the lower             hours during the first 24 hours.
   segment which does not have the same
112   MATERNAL CARE



4-40 What is the most likely cause                       NOTE   Antepartum haemorrhage could also be
of an antepartum haemorrhage                             due to vasa praevia. This rare cause of antepartum
of unknown cause?                                        haemorrhage occurs when the vessels of the
                                                         umbilical cord cross the membranes near to
A small abruptio placentae that does not cause           the internal os. When the membranes rupture, a
any other signs or symptoms. If the placental            small amount of continuous bright red bleeding
separation is going to extend, it will usually           occurs. The blood is from the fetal circulation
happen within the first 24 hours following               and, therefore, the fetus can bleed to death.
the bleed. Therefore, the patient must be                If the cervix is almost fully dilated, the fetus
                                                         can be delivered vaginally. If not, a Caesarean
hospitalised and closely observed during this
                                                         section must be done. The presence of fetal
period for signs of fetal distress.                      blood is confirmed by performing the sodium
                                                         hydroxide (Apt) test: Add one drop of blood to
4-41 How should you manage                               nine drops of 1% sodium hydroxide in a glass
a patient with an antepartum                             test tube. Read at one minute. If the blood is
haemorrhage of unknown cause?                            fetal, the mixture remains pink. However, if the
                                                         blood is maternal, the mixture becomes brown.
1. The patient must be hospitalised.
2. Careful attention must be given to fetal
   movements, especially during the first 24           REFERRAL OF A PATIENT
   hours.
                                                       WITH AN ANTEPARTUM
  NOTE If available, a cardiotocogram must
  be recorded on admission and then every
                                                       HAEMORRHAGE
  six hours during the first 24 hours.
3. If there is no further bleeding in the next         4-43 How should you decide whether
   48 hours, the patient can be discharged.            a patient can be managed locally or
   She must abstain from coitus for the rest of        whether she should be transferred?
   her pregnancy.
4. As a high-risk pregnancy, the patient must          1. Clinics and level 1 hospitals which do not
   have weekly follow-ups and is advised to               have blood available must refer all patients
   report immediately if there is any decrease            with an antepartum haemorrhage.
   in fetal movements, or further bleeding. No         2. Level 1 hospitals which have blood
   digital vaginal examination must be done.              available, and level 2 hospitals, must manage
5. The patient must be allowed to go into                 patients with the following problems:
   spontaneous labour at term.                            • A life-threatening bleed from placenta
                                                              praevia.
                                                          • Fetal distress present with a viable fetus.
 A patient with an antepartum haemorrhage of              • Abruptio placentae with a live, viable
 unknown cause must be closely observed for fetal             fetus.
 distress during the first 24 hours after the bleed.   3. Abruptio placentae with a dead fetus must
                                                          be managed in at least a level 2 hospital,
                                                          because of the risk of clotting defects.
4-42 Why is an antepartum                              4. A patient with abruptio placentae and
haemorrhage of unknown cause                              pre-eclampsia must be referred to a level 3
always regarded in a serious light?                       hospital as this patient is at high risk of
There is the possibility that abruptio placentae          pulmonary oedema and acute tubular
may be present. If the abruptio placentae                 necrosis.
is going to extend, intra-uterine death may            5. A patient with a grade 3 or 4 placenta
result. The risk of such an event is greatest             praevia and a viable fetus of less than
during the 24 hours following the bleed.                  34 weeks, who is going to be managed
ANTEPAR TUM HAEMORRHAGE      113


   conservatively, should be managed in at       4. A ‘show’ is the most likely cause of the
   least a level 2 hospital with a neonatal         discharge if the cervix is a few centimetres
   intensive care unit, or a level 3 hospital.      dilated with bulging membranes, or if the
                                                    presenting part of the fetus is visible.
4-44 When you refer a patient, what              5. A vaginitis is the most likely cause, if a
precautions should you take to ensure               blood-stained discharge is seen in the
the safety of the patient in transit?               vagina.
1. A shocked patient should have two
                                                 4-48 How should you treat a blood-stained
   intravenous infusion lines with
                                                 discharge due to vaginitis in pregnancy?
   Plasmalyte B or Ringer’s lactate running
   in fast. A doctor should accompany            1. If a microscope is available, make a wet
   the patient if possible. If not possible, a      smear of the discharge. The specific
   registered nurse should accompany her.           organism causing the vaginitis can then be
2. A patient who is no longer bleeding should       identified and treated.
   also have an intravenous infusion and
   be accompanied by a registered nurse            NOTE A wet smear of the discharge is
   whenever possible.                              made, in both saline and 2% potassium
                                                   hydroxide and examined.
                                                 2. If a microscope is not available:
A BLOOD-STAINED                                     • Organisms identified on the cervical
VAGINAL DISCHARGE                                        cytology smear are the most likely
                                                         cause of the vaginitis.
                                                    • If no organisms are identified on the
4-45 How would a patient generally                       cytology smear, or a smear was not
describe a blood-stained vaginal discharge?              done, then Trichomonas vaginalis is
                                                         most probably present.
A patient would probably describe a blood-
stained vaginal discharge as a vaginal           To treat a Trichomonal vaginitis, both the
discharge mixed with a small amount of blood.    patient and her partner should receive a single
                                                 dose of 2 g metronidazole (Flagyl) orally.
4-46 How would a patient generally
describe a ‘show’?                               4-49 Should metronidazole be
                                                 used during pregnancy?
A patient would probably describe a ‘show’
as a slight vaginal bleed consisting of blood    Metronidazole should not be used in the first
mixed with mucus.                                trimester of pregnancy, unless absolutely
                                                 necessary, as it may cause congenital
4-47 How should you manage a patient             abnormalities in the fetus. The patient and her
with a history of a blood-stained                partner must be warned that metronidazole
vaginal discharge or a ‘show’?                   causes severe nausea and vomiting if it is
                                                 taken with alcohol. The risk of congenital
1. After getting a good history and              abnormalities caused by alcohol may also be
   ensuring that the condition of the            increased by metronidazole.
   fetus is satisfactory, a careful speculum
   examination should be done.
                                                 4-50 How do you manage a patient
2. The speculum is only inserted for 5 cm,
                                                 with contact bleeding?
   carefully opened, and then introduced
   further until the cervix can be seen.         1. When there is normal cervical cytology
3. Any bleeding through a closed cervical os        (Papanicolaou smear), the contact bleeding
   indicates an antepartum haemorrhage.
114   MATERNAL CARE



   is probably due to a cervicitis. If it is        4. What should be done once the
   troublesome, the patient should be given         condition of the patient and her
   a course of oral erythromycin 500 mg             fetus have been assessed, and the
   six-hourly for seven days.                       patient resuscitated, if necessary?
2. With abnormal cervical cytology, the
                                                    The cause of the antepartum haemorrhage
   patient should be managed correctly.
                                                    must be sought and managed.
   Cervical intra-epithelial neoplasia causes
   contact bleeding.

4-51 What action should you take when the
                                                    CASE STUDY 2
bleeding is from a cervical ulcer or tumour?
                                                    A patient who is 32 weeks pregnant,
The patient most probably has an infiltrating       according to her antenatal card, presents
cervical carcinoma and should be correctly          with a history of severe vaginal bleeding and
managed.                                            abdominal pain. The blood contains dark
                                                    clots. Since the haemorrhage, the patient has
  NOTE When there is doubt about the
                                                    not felt her fetus move. The patient’s blood
  diagnosis, a cytology smear and biopsy
                                                    pressure is 80/60 mm Hg and the pulse rate
  of the lesion must be taken. The results
  should be obtained as soon as possible.           120 beats per minute.

                                                    1. What is your clinical diagnosis?
CASE STUDY 1                                        The history is typical of an abruptio placentae.

A patient who is 35 weeks pregnant presents         2. If the clinical examination confirms the
with a history of vaginal bleeding.                 diagnosis, what should be the first step
                                                    in the management of this patient?
1. Why does this patient need
                                                    The patient’s blood pressure and pulse rate
to be assessed urgently?
                                                    indicate that she is shocked. Therefore, she
Because an antepartum haemorrhage should            must first be resuscitated.
always be regarded as an emergency, until a
cause for the bleeding is found. Thereafter, the    3. What is the next step that
correct management can be given.                    requires urgent attention in the
                                                    management of the patient?
2. What is the first step in the
                                                    As the fetus is viable, it is of great importance
management of a patient with an
                                                    to establish whether the fetus is still alive.
antepartum haemorrhage?
                                                    Therefore, it must be urgently established
The clinical condition of the patient must          whether the fetal heartbeat is present or not.
be assessed. Special attention must be
paid to signs of shock. If shock is present,        4. How should you manage the patient
resuscitation must be started urgently.             if a fetal heartbeat is heard?
                                                    A vaginal examination must be done. If
3. What is the next step in the
                                                    the cervix is 9 cm or more dilated and the
management of a patient with an
                                                    fetal head is on the pelvic floor, then the
antepartum haemorrhage?
                                                    membranes should be ruptured and the fetus
The condition of the fetus must be assessed.        delivered vaginally as quickly as possible.
The presence of fetal distress will influence the   Otherwise, an emergency Caesarean section
choice of management.                               must be done as soon as the patient has been
ANTEPAR TUM HAEMORRHAGE      115


resuscitated. Immediately before starting the       3. How should the patient be managed
Caesarean section, make sure that the fetal         if she should have a severe bleed?
heartbeat is still present.
                                                    An emergency Caesarean section must
                                                    be done, as soon as the patient has been
5. Should the above patient be                      adequately resuscitated.
transferred to a level 2 or 3 hospital
for delivery, if the fetus is still alive?
                                                    4. What investigations should be done
The patient should be delivered in any hospital     if the patient is not bleeding actively
which has facilities for doing a Caesarean          during your initial clinical examination?
section. Moving the patient because the fetus
                                                    A ultrasound examination must be done to
is regarded as preterm may result in an intra-
                                                    confirm the clinical diagnosis. After placenta
uterine death during transport. If necessary,
                                                    praevia has been excluded, a careful speculum
the newborn infant can be transported to a
                                                    examination should be done to exclude any
level 2 hospital with a neonatal intensive care
                                                    local cause for the bleeding.
unit. The risk of a clotting defect is low if the
fetus is still alive.
                                                    5. How should the patient be managed
                                                    if she has had no further severe
6. How should you manage this patient
                                                    bleeding after the initial bleed?
if a fetal heartbeat is not heard?
                                                    She should be hospitalised and managed
The membranes should be ruptured and the
                                                    conservatively until 36 or 38 weeks gestation,
fetus delivered vaginally, if possible.
                                                    or until she starts to bleed actively again.
                                                    Depending on the degree of placenta praevia,
                                                    a Caesarean section should be done at 36 or 38
CASE STUDY 3                                        weeks or spontaneous labour can be awaited.

A patient is seen at the antenatal clinic at 35
weeks gestation with a breech presentation.         CASE STUDY 4
The patient is referred to see the doctor the
following week, for an external cephalic
                                                    A patient books for antenatal care at 30 weeks
version. That evening she has a painless, bright
                                                    gestation. When you inform her of the danger
red vaginal bleed.
                                                    signs during pregnancy, she says that she has
                                                    had a vaginal discharge for the past two weeks.
1. What is your diagnosis?                          At times the discharge has been blood stained.
The history and the presence of an abnormal
lie suggest that the bleeding is the result of a    1. Has this patient had a
placenta praevia.                                   antepartum haemorrhage?
                                                    The history suggests a blood-stained vaginal
2. What should the initial                          discharge rather than an antepartum
management of the patient be?                       haemorrhage.
The condition of the mother should first
be assessed and the patient resuscitated, if        2. What is the most probable cause of
necessary. Then the fetal condition must be         the blood-stained vaginal discharge?
assessed. The patient’s abdomen should also be
                                                    A vaginitis. This can usually be confirmed by a
examined, to determine whether the clinical
                                                    speculum examination.
signs support the diagnosis of placenta praevia.
116   MATERNAL CARE



3. How can the cause of the                     vaginalis is presumed to be the cause of the
vaginitis be determined?                        vaginitis.
During the speculum examination, a sample of
the discharge should be taken and a wet smear   5. How should you treat a patient
made. Organisms seen on the wet smear are       with Trichomonal vaginitis?
probably the cause of the vaginitis.            A single dose of 2 g metronidazole (Flagyl)
                                                is given orally to both the patient and her
4. What is the most likely cause of a           partner. Both must be warned against
vaginitis with a blood-stained discharge?       drinking alcohol for a few days after taking
                                                metronidazole.
Trichomonas vaginalis. Therefore, if a
microscope is not available, Trichomonas

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Antepartum Haemorrhage Causes and Management

  • 1. 4 Antepartum haemorrhage Before you begin this unit, please take the ANTEPARTUM corresponding test at the end of the book to assess your knowledge of the subject matter. You HAEMORRHAGE should redo the test after you’ve worked through the unit, to evaluate what you have learned. 4-1 What is an antepartum haemorrhage? An antepartum haemorrhage is any vaginal Objectives bleeding which occurs at or after 24 weeks (estimated fetal weight at 24 weeks = 500 g) and before the birth of the infant. A bleed before 28 When you have completed this unit you weeks is regarded as a threatened miscarriage as should be able to: the fetus is usually considered not to be viable. • Understand why an antepartum haemorrhage should always be regarded NOTE A fetus is viable from 28 weeks, or an estimated weight of 1000 g, if the duration as serious. of pregnancy is uncertain. Antepartum • Provide the initial management of a haemorrhage before the fetus is viable has patient presenting with an antepartum the same serious complications as that with a haemorrhage. viable fetus. In both cases, the management is the same except for fetal monitoring, which • Understand that it is sometimes is only done from 28 weeks (or 1000 g). necessary to deliver the fetus as soon as possible, in order to save the life of the 4-2 Why is an antepartum haemorrhage mother or infant. such a serious condition? • Diagnose the cause of the bleeding 1. The bleeding can be so severe that it can from the history and examination of the endanger the life of both the mother and patient. fetus. • Correctly manage each of the causes of 2. Abruptio placentae is a common cause antepartum haemorrhage. of antepartum haemorrhage and an important cause of perinatal death in • Diagnose the cause of a blood-stained many communities. vaginal discharge and administer appropriate treatment. Therefore, all patients who present with an antepartum haemorrhage must be regarded as
  • 2. ANTEPAR TUM HAEMORRHAGE 101 serious emergencies until a diagnosis has been 2. Assess the condition of the fetus. If the made. Further management will depend on fetus is viable but distressed, an emergency the cause of the haemorrhage. delivery is needed. 3. Diagnose the cause of the bleeding, taking the clinical findings into account Any vaginal bleeding during pregnancy may be and, if necessary, the results of special an important danger sign that must be reported investigations. immediately. The initial management and diagnosis of a patient with vaginal bleeding is summarised in 4-3 What advice about vaginal bleeding Flow diagram 4-1. should you give to all patients? Every patient must be advised that any vaginal 4-5 What symptoms and signs indicate that bleeding is potentially serious and told that this the patient is shocked due to blood loss? complication must be reported immediately. 1. Dizziness is the commonest symptom of shock. 4-4 What is the management of 2. On general examination the patient an antepartum haemorrhage? is sweating, her skin and mucous The management consists of four important membranes are pale, and she feels cold steps that should be carried out in the and clammy to the touch. following order: 3. The blood pressure is low and the pulse rate fast. 1. The maternal condition must be evaluated and stabilised, if necessary. 4-6 How should you manage a shocked 2. The condition of the fetus must then be patient with an antepartum haemorrhage? assessed. 3. The cause of the haemorrhage must be When there are symptoms and signs to diagnosed. indicate that the patient is shocked, you must: 4. Finally, the definitive management of an 1. Put up two intravenous infusions (‘drips’) antepartum haemorrhage, depending on with Balsol or Ringer’s lactate, to run in the cause, must be given. quickly in order to actively resuscitate the It must also be decided whether the patient patient. should be transferred for further treatment. 2. Insert a Foley catheter into the patient’s bladder to measure the urinary volume and to monitor further urine output. THE INITIAL EMERGENCY 3. If blood is available, take blood for cross- matching at the time of putting up the MANAGEMENT intravenous infusion and order two or OF ANTEPARTUM more units of blood urgently. 4. Listen to the fetal heart: HAEMORRHAGE • If fetal distress is present and the fetus is assessed to be viable (28 weeks or an The management must always be provided in estimated weight of 1000 g or more), the following order: then deliver by the quickest possible 1. Assess the condition of the patient. If the method, usually by Caesarean section. patient is shocked, she must be resuscitated • If fetal distress is excluded, if the fetus immediately. is too preterm to be viable, or if there is an intra-uterine death, then more attention can be given to the history
  • 3. 102 MATERNAL CARE History of vaginal Maternal condition? Not shocked bleeding Resuscitate Shocked No Yes A life-threatening Refer for urgent haemorrhage? Fetal stress? delivery Yes No Refer for urgent What type of Antepartum Speculum Caesarean section bleed? haemorrhage examination Blood mixed with No local mucus, or blood- Local cause, eg. cause stained discharge vaginitis or local found lesion Treat local Decide between: ‘Show’ or 1. Placenta praevia vaginitis cause of bleeding 2. Abruptio placentae and refer Flow diagram 4-1: Initial management of a patient with vaginal bleeding
  • 4. ANTEPAR TUM HAEMORRHAGE 103 and examination of the patient in If the maternal and fetal conditions are order to make a diagnosis of the cause satisfactory, then a careful speculum of the bleeding. examination should be done to exclude a local cause of the bleeding. Do not perform a 4-7 What must you do if a patient presents digital vaginal examination, as this may cause with a life-threatening haemorrhage? a massive haemorrhage if the patient has a placenta praevia. The maternal condition takes preference over that of the fetus. The patient, therefore, is actively resuscitated while arrangements Do not do a digital vaginal examination until are made to terminate the pregnancy by placenta praevia has been excluded. Caesarean section. 4-9 How does a speculum examination help you determine the cause of the bleeding? DIAGNOSING THE CAUSE 1. Bleeding through a closed cervical os OF THE BLEEDING confirms the diagnosis of a haemorrhage. 2. If the cervix is a few centimetres dilated with bulging membranes, or the presenting 4-8 Should you treat all patients part of the fetus is visible, this suggests that with antepartum haemorrhage in the bleed was a ‘show’. the same way, irrespective of the 3. A blood-stained discharge in the vagina, amount and character of the bleed? with no bleeding through the cervical os, No. The management differs depending on suggests a vaginitis. whether the vaginal bleeding is diagnosed 4. Bleeding from the surface of the cervix as a ‘haemorrhage’ on the one hand, or a caused by contact with the speculum (i.e. blood-stained vaginal discharge or a ‘show’ contact bleeding) may indicate a cervicitis on the other hand. A careful assessment of or cervical intra-epithelial neoplasia (CIN). the amount and type of bleeding is, therefore, 5. Bleeding from a cervical tumour or very important. an ulcer may indicate an infiltrating carcinoma. 1. Any vaginal bleeding at or after 24 weeks must be diagnosed as an antepartum haemorrhage if any of the following are 4-10 Can you rely on clinical findings to present: determine the cause of a haemorrhage? • A sanitary pad is at least partially In many cases the history and examination of soaked with blood. the abdomen will enable the patient to be put • Blood runs down the patient’s legs. into one of two groups: • A clot of blood has been passed. 1. Abruptio placentae. A diagnosis of a haemorrhage always suggests 2. Placenta praevia. a serious complication. There are some patients in whom no reason 1. A blood-stained vaginal discharge will for the haemorrhage can be found. Such a consist of a discharge mixed with a small haemorrhage is classified as an antepartum amount of blood. haemorrhage of unknown cause. 2. A ‘show’ will consist of a small amount of blood mixed with mucus. The blood- stained vaginal discharge or ‘show’ will be present on the surface of the sanitary pad but will not soak it.
  • 5. 104 MATERNAL CARE 4-11 What is the most likely cause of the other hypertensive disorders of of an antepartum haemorrhage pregnancy. with fetal distress? 3. Intra-uterine growth restriction. 4. Cigarette smoking. Abruptio placentae is the commonest cause 5. Poor socio-economic conditions. of antepartum haemorrhage leading to fetal 6. A history of abdominal trauma, e.g. a fall distress. However, sometimes there may be or kick on the abdomen. very little or no bleeding even with a severe abruptio placentae. 4-15 What symptoms point to a diagnosis of abruptio placentae? An antepartum haemorrhage with fetal distress 1. An antepartum haemorrhage which or fetal death is almost always due to abruptio is associated with continuous severe placentae. abdominal pain. 2. A history that the blood is dark red with 4-12 What is the most likely cause of a life- clots. threatening antepartum haemorrhage? 3. Absence of fetal movements following the bleeding. A placenta praevia is the most likely cause of a massive antepartum haemorrhage that threatens the patient’s life. 4-16 What do you expect to find on examination of the patient? 1. The general examination and observations ANTEPARTUM BLEEDING show that the patient is shocked, often CAUSED BY ABRUPTIO out of proportion to the amount of visible blood loss. PLACENTAE 2. The patient usually has severe abdominal pain. 3. The abdominal examination shows the 4-13 What is abruptio placentae? following: Abruptio placentae (placental abruption) • The uterus is tonically contracted, hard means that part or all of the normally and tender, so much so that the whole implanted placenta has separated from the abdomen may be rigid. uterus before delivery of the fetus. The cause of • Fetal parts cannot be palpated. abruptio placentae remains unknown. • The uterus is bigger than the patient’s dates suggest. • The haemoglobin concentration is low, 4-14 Which patients are at increased indicating severe blood loss. risk of abruptio placentae? 4. The fetal heartbeat is almost always absent Patients with: in a severe abruptio placentae. 1. A history of an abruptio placentae in a These symptoms and signs are typical of a previous pregnancy. (There is a 10% chance severe abruptio placentae. However, abruptio of recurrence after an abruptio placentae placentae may present with symptoms and in a previous pregnancy and a 25% chance signs which are less obvious, making the after two previous pregnancies with an diagnosis difficult. abruptio placentae.) The management of abruptio placentae is 2. Pre-eclampsia (gestational proteinuric summarised in flow diagram 4-2. hypertension) and, to a lesser extent, any
  • 6. ANTEPAR TUM HAEMORRHAGE 105 Antepartum haemmorhage with symptoms or signs of abruptio placentae Shocked Maternal condition? Not shocked Fetal heart No Rupture Resuscitate Vaginal delivery present? membranes Yes Yes No Vaginal Fetus viable? examination Cervix 9 cm or more dliated and No Caesarean fetal head section engaged? Yes Vaginal delivery Flow diagram 4-2: Management of a patient with an abruptio placentae
  • 7. 106 MATERNAL CARE 4-19 What should you do if the The diagnosis of severe abruptio placentae can fetal heartbeat is absent? usually be made from the history and physical examination. 1. Active resuscitation of the mother is a priority and should have been started as part of the initial emergency management: 4-17 What would you do if the fetal • Two intravenous infusion lines are heartbeat was still present? usually needed, one of which can be a If the fetal heartbeat is still present with an central venous pressure line inserted in abruptio placentae, there will usually be signs the antecubital fossa. of fetal distress. The infant will die in utero if • Two units of fresh frozen plasma, not delivered immediately. and at least four units of whole blood are usually needed for effective 4-18 How should you decide on resuscitation. the method of delivery if the fetal 2. A Foley catheter is inserted into the heartbeat is still present? bladder. 3. The pulse rate and blood pressure must 1. If the symptoms and signs are typical of an be checked every 15 minutes until the abruptio placentae, a vaginal examination patient’s condition stabilises, and half- should be done. hourly thereafter. The urinary output must 2. If the cervix is at least 9 cm dilated, and the be recorded hourly. presenting part is well down in the pelvis, 4. The membranes are then ruptured, then the membranes should be ruptured following which cervical dilatation and and the infant delivered vaginally. If these delivery of the fetus usually occur quickly. conditions are not present, an emergency 5. Pain relief in the form of pethidine or Caesarean section should be done. morphine and promethazine (Phenegan) 3. If the fetus is not viable, it should be or hydroxyzine (Aterax) should be given delivered vaginally if the diagnosis is once the patient is adequately resuscitated. abruptio placentae. 4. While preparations for delivery are being 4-20 Why is it important to remember that made, the mother must be resuscitated many patients with abruptio placentae and intra-uterine resuscitation of the fetus have underlying pre-eclampsia? started. However, salbutamol or nifedipine must not be given to a patient who shows 1. Signs of shock may be present even with any evidence of shock. a normal blood pressure. These patients, 5. When there is doubt about the diagnosis, nevertheless, need active resuscitation. specifically when placenta praevia cannot 2. After resuscitation a hypotensive patient be excluded on history and examination, may become hypertensive, so much so that then a digital vaginal examination should dihydralazine (Nepresol) may have to be not be done. If fetal distress is present and given parenterally or nifedipine (Adalat) the fetus is viable, a Caesarean section orally. must be done. If there is neither fetal 3. Magnesium sulphate must be given if the distress nor severe vaginal bleeding, the patient develops imminent eclampsia. possibility of a placenta praevia must be investigated. An ultrasound examination NOTE These patients are haemodynamically very or vaginal examination in theatre must unstable. Although initially they also require active resuscitation, they quickly become then be done. fluid overloaded, resulting in pulmonary oedema. Renal complications, such as acute tubular necrosis, commonly occur.
  • 8. ANTEPAR TUM HAEMORRHAGE 107 4-21 At your initial assessment of • Are grande multiparas, i.e. who are the patient, how would you know para 5 or higher. whether or not there is underlying • Have had a previous Caesarean section. pre-eclampsia present? 2. With regard to their present obstetric history, patients who: By finding protein in the patient’s urine. • Have a multiple pregnancy. • Have had a threatened abortion, Abruptio placentae with pre-eclampsia is a serious especially in the second trimester. condition with a high risk of maternal death. • Have an abnormal presentation. 4-22 What complication should 4-26 What in the history of the bleeding you watch for after delivery? suggests the diagnosis of placenta praevia? Postpartum haemorrhage, as this is common 1. The bleeding is painless and bright red in after abruptio placentae. colour. 2. Fetal movements are still present after the bleed. 4-23 What action should you take to prevent postpartum haemorrhage? 4-27 What are the typical findings 1. Syntometrine 1 ampoule should be given on physical examination in a intramuscularly, if the patient is not patient with placenta praevia? hypertensive. Only oxytocin is used in a hypertensive patient. 1. General examination may show signs that 2. In addition, 20 units of oxytocin are put in the patient is shocked, and the amount the intravenous infusion bottle. of bleeding corresponds to the degree 3. The uterus is rubbed up well. of shock. The patient’s haemoglobin 4. The patient is carefully observed for concentration is normal or low depending bleeding. on the amount of blood loss and the time interval between the haemorrhage and the haemoglobin measurement. However, the ANTEPARTUM first bleed is usually not severe. 2. Examination of the abdomen shows that: BLEEDING CAUSED BY • The uterus is soft and not tender to PLACENTA PRAEVIA palpation. • The uterus is not bigger than it should be for the patient’s dates. 4-24 What is placenta praevia? • The fetal parts can be easily palpated, and the fetal heart is present. Placenta praevia means that the placenta is • There may be an abnormal implanted either wholly or partially in the lower presentation. Breech presentation or segment of the uterus. It may extend down to, oblique or transverse lies are commonly or cover the internal os of the cervix. When present. the lower segment starts to form or the cervix • In cephalic presentations, the head is begins to dilate, the placenta becomes partially not engaged and is easily balottable separated and this causes maternal bleeding. above the pelvis. 4-25 Which patients have the highest risk of placenta praevia? The diagnosis of placenta praevia can usually be 1. With regard to their previous obstetric made from the history and physical examination. history, patients who:
  • 9. 108 MATERNAL CARE 4-28 Do you think that engagement 4-32 What is the further management after of the head can occur if there is making the diagnosis of placenta praevia? a placenta praevia present? 1. If the patient is not bleeding actively, No. If there is 2/5 or less of the fetal head further management depends on the palpable above the pelvic brim on abdominal gestational age: examination, then placenta praevia can be • With a gestational age of less than 38 excluded and a digital vaginal examination can weeks, the patient is hospitalised and be done safely. The first vaginal examination managed conservatively until 38 weeks must always be done carefully. or until active bleeding starts. • If the fetus is viable (28 weeks or more) but the gestational age is less Two fifths or less of the fetal head palpable than 34 weeks, steroids must be given above the pelvic brim excludes the possibility of to stimulate fetal lung maturity as placenta praevia. delivery may become necessary within a few days. 4-29 What do you understand • With a gestational age of 38 weeks or by a ‘warning bleed’? more, the fetus should be delivered. The further management of a patient This is the first bleeding that occurs from a when her pregnancy has reached 36 weeks placenta praevia, when the lower segment depends on the grade of placenta praevia. begins to form at about 34 weeks, or even 2. A patient who is actively bleeding must be earlier. delivered irrespective of the gestational age, because this is a life-threatening condition 4-30 Are there any investigations that can for the patient. An emergency Caesarean confirm the diagnosis of placenta praevia? section or hysterotomy must be done. 1. If the patient is less than 38 weeks pregnant The management of a patient with a placenta and not bleeding actively, an ultrasound praevia is summarised in flow diagrams 4-3 examination must be done in order to and 4-4. localise the placenta. 2. If the patient is 38 or more weeks pregnant, 4-33 When a patient with placenta and not bleeding actively: praevia is less than 38 weeks pregnant • If ultrasonology is available, an and is being managed conservatively, ultrasound examination can be done in what amount of bleeding would indicate order to localise the placenta. that you should deliver the fetus? • If ultrasonology is not available, a digital vaginal examination can be done 1. Any sudden, severe haemorrhage. in theatre with everything ready for a 2. Any continuous, moderate bleeding, such Caesarean section. that the drop in the patient’s haemoglobin concentration requires a blood transfusion. 4-31 What action should you take if a routine ultrasound examination early in 4-34 How will you further manage a patient pregnancy shows a placenta praevia? who has been treated conservatively? In most cases, the position of the placenta 1. With a grade 3 or 4 placenta praevia, a moves away from the internal os of the Caesarean section should be done at 36 cervix as pregnancy continues. A follow-up weeks. ultrasound examination must be arranged at a 2. With a grade 2 placenta praevia, a gestational age of 32 weeks. Caesarean section should be done at 38 weeks.
  • 10. ANTEPAR TUM HAEMORRHAGE 109 Antepartum haemorrhage with Maternal condition? symptoms or signs of placenta praevia Resuscitate Shocked Not shocked Caesarean Yes No section if fetus ltrasound Fetal distress? examination viable Continuing Yes Caesarean Yes lacenta bleeding with a ospitalise section praevia? fall in b? No No A of No ocal See flow ed rest to unknown cause? diagram V weeks cause Yes reat local cause Flow diagram 4-3: Management of a patient with a placenta praevia before 36 weeks
  • 11. 110 MATERNAL CARE lacenta praevia of weeks or more rade of placenta praevia? rade with rade or bleeding or rade with engaged head and rade of placenta placenta unengaged head praevia uncertain covering internal or rade no bleeding cervical os ait for ait for Caesarian weeks or spontaneous section bleeding onset of labour Careful vaginal examination lacental tissue palpable in lower segment? Yes No Caesarean Rupture membranes section and deliver vaginally Flow diagram 4-4: Management of a patient with a placenta praevia at 36 weeks or more
  • 12. ANTEPAR TUM HAEMORRHAGE 111 3. With a grade 1 placenta praevia which ability as the upper segment to contract bleeds now, and a presenting part that and retract after delivery. Therefore, remains high above the pelvis, a Caesarean the same measures taken with abruptio section should be done at 38 weeks. placentae must be taken to prevent 4. With a grade 1 placenta praevia, which postpartum haemorrhage. does not bleed and where the fetal head is engaged (2/5 or less palpable above the brim), you can wait for the spontaneous ANTEPARTUM onset of labour. The first vaginal examination must be done very carefully. HAEMORRHAGE OF UNKNOWN CAUSE 4-35 How do you go about doing a vaginal examination in theatre? 4-38 When would you suspect 1. The theatre sister must be scrubbed up an antepartum haemorrhage with her trolley ready. of unknown cause? 2. The anaesthetist must be ready with his drugs drawn up so that, if necessary, he can In patients who fulfill all the following proceed immediately with the induction of requirements: anaesthesia. 1. Less severe antepartum bleeding, without 3. A careful digital examination must be signs of shock, and when the fetal done. First feel in all four vaginal fornices: condition is good. • If there is soft tissue between the 2. When the history and examination do not examining finger and the fetal skull, suggest a severe abruptio placentae. then placenta praevia is diagnosed. 3. When local causes have been excluded on • If the fetal skull is easily felt in all four speculum examination. fornices, then a careful examination is 4. When placenta praevia has been excluded done through the cervix. by an ultrasound examination. • If placental tissue is felt, then a Caesarean section should be done. If 4-39 What should you do to exclude not, the membranes can be ruptured other causes of bleeding if you do with the aim of allowing a vaginal not have ultrasound facilities ? delivery. 1. Abruptio placentae can usually be excluded on history and examination. 4-36 If the fetus is alive, why is urgent 2. Local causes are excluded on speculum delivery of less importance in placenta examination. praevia than in abruptio placentae? 3. With a gestational age of 38 weeks or more, Compared with abruptio placentae, intra- a vaginal examination is done in theatre to uterine death is uncommon in placenta confirm or exclude placenta praevia. praevia. However, a serious vaginal bleed due 4. If the gestational age is less than 38 to placenta praevia may still necessitate an weeks, the patient must be admitted to immediate delivery to save the mother’s life. hospital and close attention paid to fetal movements, especially in the first 24 hours. 4-37 Why do patients with a placenta NOTE If available, antenatal fetal heart praevia have an increased risk of rate monitoring should be done on postpartum haemorrhage? admission to hospital and every six 1. The placenta was implanted in the lower hours during the first 24 hours. segment which does not have the same
  • 13. 112 MATERNAL CARE 4-40 What is the most likely cause NOTE Antepartum haemorrhage could also be of an antepartum haemorrhage due to vasa praevia. This rare cause of antepartum of unknown cause? haemorrhage occurs when the vessels of the umbilical cord cross the membranes near to A small abruptio placentae that does not cause the internal os. When the membranes rupture, a any other signs or symptoms. If the placental small amount of continuous bright red bleeding separation is going to extend, it will usually occurs. The blood is from the fetal circulation happen within the first 24 hours following and, therefore, the fetus can bleed to death. the bleed. Therefore, the patient must be If the cervix is almost fully dilated, the fetus can be delivered vaginally. If not, a Caesarean hospitalised and closely observed during this section must be done. The presence of fetal period for signs of fetal distress. blood is confirmed by performing the sodium hydroxide (Apt) test: Add one drop of blood to 4-41 How should you manage nine drops of 1% sodium hydroxide in a glass a patient with an antepartum test tube. Read at one minute. If the blood is haemorrhage of unknown cause? fetal, the mixture remains pink. However, if the blood is maternal, the mixture becomes brown. 1. The patient must be hospitalised. 2. Careful attention must be given to fetal movements, especially during the first 24 REFERRAL OF A PATIENT hours. WITH AN ANTEPARTUM NOTE If available, a cardiotocogram must be recorded on admission and then every HAEMORRHAGE six hours during the first 24 hours. 3. If there is no further bleeding in the next 4-43 How should you decide whether 48 hours, the patient can be discharged. a patient can be managed locally or She must abstain from coitus for the rest of whether she should be transferred? her pregnancy. 4. As a high-risk pregnancy, the patient must 1. Clinics and level 1 hospitals which do not have weekly follow-ups and is advised to have blood available must refer all patients report immediately if there is any decrease with an antepartum haemorrhage. in fetal movements, or further bleeding. No 2. Level 1 hospitals which have blood digital vaginal examination must be done. available, and level 2 hospitals, must manage 5. The patient must be allowed to go into patients with the following problems: spontaneous labour at term. • A life-threatening bleed from placenta praevia. • Fetal distress present with a viable fetus. A patient with an antepartum haemorrhage of • Abruptio placentae with a live, viable unknown cause must be closely observed for fetal fetus. distress during the first 24 hours after the bleed. 3. Abruptio placentae with a dead fetus must be managed in at least a level 2 hospital, because of the risk of clotting defects. 4-42 Why is an antepartum 4. A patient with abruptio placentae and haemorrhage of unknown cause pre-eclampsia must be referred to a level 3 always regarded in a serious light? hospital as this patient is at high risk of There is the possibility that abruptio placentae pulmonary oedema and acute tubular may be present. If the abruptio placentae necrosis. is going to extend, intra-uterine death may 5. A patient with a grade 3 or 4 placenta result. The risk of such an event is greatest praevia and a viable fetus of less than during the 24 hours following the bleed. 34 weeks, who is going to be managed
  • 14. ANTEPAR TUM HAEMORRHAGE 113 conservatively, should be managed in at 4. A ‘show’ is the most likely cause of the least a level 2 hospital with a neonatal discharge if the cervix is a few centimetres intensive care unit, or a level 3 hospital. dilated with bulging membranes, or if the presenting part of the fetus is visible. 4-44 When you refer a patient, what 5. A vaginitis is the most likely cause, if a precautions should you take to ensure blood-stained discharge is seen in the the safety of the patient in transit? vagina. 1. A shocked patient should have two 4-48 How should you treat a blood-stained intravenous infusion lines with discharge due to vaginitis in pregnancy? Plasmalyte B or Ringer’s lactate running in fast. A doctor should accompany 1. If a microscope is available, make a wet the patient if possible. If not possible, a smear of the discharge. The specific registered nurse should accompany her. organism causing the vaginitis can then be 2. A patient who is no longer bleeding should identified and treated. also have an intravenous infusion and be accompanied by a registered nurse NOTE A wet smear of the discharge is whenever possible. made, in both saline and 2% potassium hydroxide and examined. 2. If a microscope is not available: A BLOOD-STAINED • Organisms identified on the cervical VAGINAL DISCHARGE cytology smear are the most likely cause of the vaginitis. • If no organisms are identified on the 4-45 How would a patient generally cytology smear, or a smear was not describe a blood-stained vaginal discharge? done, then Trichomonas vaginalis is most probably present. A patient would probably describe a blood- stained vaginal discharge as a vaginal To treat a Trichomonal vaginitis, both the discharge mixed with a small amount of blood. patient and her partner should receive a single dose of 2 g metronidazole (Flagyl) orally. 4-46 How would a patient generally describe a ‘show’? 4-49 Should metronidazole be used during pregnancy? A patient would probably describe a ‘show’ as a slight vaginal bleed consisting of blood Metronidazole should not be used in the first mixed with mucus. trimester of pregnancy, unless absolutely necessary, as it may cause congenital 4-47 How should you manage a patient abnormalities in the fetus. The patient and her with a history of a blood-stained partner must be warned that metronidazole vaginal discharge or a ‘show’? causes severe nausea and vomiting if it is taken with alcohol. The risk of congenital 1. After getting a good history and abnormalities caused by alcohol may also be ensuring that the condition of the increased by metronidazole. fetus is satisfactory, a careful speculum examination should be done. 4-50 How do you manage a patient 2. The speculum is only inserted for 5 cm, with contact bleeding? carefully opened, and then introduced further until the cervix can be seen. 1. When there is normal cervical cytology 3. Any bleeding through a closed cervical os (Papanicolaou smear), the contact bleeding indicates an antepartum haemorrhage.
  • 15. 114 MATERNAL CARE is probably due to a cervicitis. If it is 4. What should be done once the troublesome, the patient should be given condition of the patient and her a course of oral erythromycin 500 mg fetus have been assessed, and the six-hourly for seven days. patient resuscitated, if necessary? 2. With abnormal cervical cytology, the The cause of the antepartum haemorrhage patient should be managed correctly. must be sought and managed. Cervical intra-epithelial neoplasia causes contact bleeding. 4-51 What action should you take when the CASE STUDY 2 bleeding is from a cervical ulcer or tumour? A patient who is 32 weeks pregnant, The patient most probably has an infiltrating according to her antenatal card, presents cervical carcinoma and should be correctly with a history of severe vaginal bleeding and managed. abdominal pain. The blood contains dark clots. Since the haemorrhage, the patient has NOTE When there is doubt about the not felt her fetus move. The patient’s blood diagnosis, a cytology smear and biopsy pressure is 80/60 mm Hg and the pulse rate of the lesion must be taken. The results should be obtained as soon as possible. 120 beats per minute. 1. What is your clinical diagnosis? CASE STUDY 1 The history is typical of an abruptio placentae. A patient who is 35 weeks pregnant presents 2. If the clinical examination confirms the with a history of vaginal bleeding. diagnosis, what should be the first step in the management of this patient? 1. Why does this patient need The patient’s blood pressure and pulse rate to be assessed urgently? indicate that she is shocked. Therefore, she Because an antepartum haemorrhage should must first be resuscitated. always be regarded as an emergency, until a cause for the bleeding is found. Thereafter, the 3. What is the next step that correct management can be given. requires urgent attention in the management of the patient? 2. What is the first step in the As the fetus is viable, it is of great importance management of a patient with an to establish whether the fetus is still alive. antepartum haemorrhage? Therefore, it must be urgently established The clinical condition of the patient must whether the fetal heartbeat is present or not. be assessed. Special attention must be paid to signs of shock. If shock is present, 4. How should you manage the patient resuscitation must be started urgently. if a fetal heartbeat is heard? A vaginal examination must be done. If 3. What is the next step in the the cervix is 9 cm or more dilated and the management of a patient with an fetal head is on the pelvic floor, then the antepartum haemorrhage? membranes should be ruptured and the fetus The condition of the fetus must be assessed. delivered vaginally as quickly as possible. The presence of fetal distress will influence the Otherwise, an emergency Caesarean section choice of management. must be done as soon as the patient has been
  • 16. ANTEPAR TUM HAEMORRHAGE 115 resuscitated. Immediately before starting the 3. How should the patient be managed Caesarean section, make sure that the fetal if she should have a severe bleed? heartbeat is still present. An emergency Caesarean section must be done, as soon as the patient has been 5. Should the above patient be adequately resuscitated. transferred to a level 2 or 3 hospital for delivery, if the fetus is still alive? 4. What investigations should be done The patient should be delivered in any hospital if the patient is not bleeding actively which has facilities for doing a Caesarean during your initial clinical examination? section. Moving the patient because the fetus A ultrasound examination must be done to is regarded as preterm may result in an intra- confirm the clinical diagnosis. After placenta uterine death during transport. If necessary, praevia has been excluded, a careful speculum the newborn infant can be transported to a examination should be done to exclude any level 2 hospital with a neonatal intensive care local cause for the bleeding. unit. The risk of a clotting defect is low if the fetus is still alive. 5. How should the patient be managed if she has had no further severe 6. How should you manage this patient bleeding after the initial bleed? if a fetal heartbeat is not heard? She should be hospitalised and managed The membranes should be ruptured and the conservatively until 36 or 38 weeks gestation, fetus delivered vaginally, if possible. or until she starts to bleed actively again. Depending on the degree of placenta praevia, a Caesarean section should be done at 36 or 38 CASE STUDY 3 weeks or spontaneous labour can be awaited. A patient is seen at the antenatal clinic at 35 weeks gestation with a breech presentation. CASE STUDY 4 The patient is referred to see the doctor the following week, for an external cephalic A patient books for antenatal care at 30 weeks version. That evening she has a painless, bright gestation. When you inform her of the danger red vaginal bleed. signs during pregnancy, she says that she has had a vaginal discharge for the past two weeks. 1. What is your diagnosis? At times the discharge has been blood stained. The history and the presence of an abnormal lie suggest that the bleeding is the result of a 1. Has this patient had a placenta praevia. antepartum haemorrhage? The history suggests a blood-stained vaginal 2. What should the initial discharge rather than an antepartum management of the patient be? haemorrhage. The condition of the mother should first be assessed and the patient resuscitated, if 2. What is the most probable cause of necessary. Then the fetal condition must be the blood-stained vaginal discharge? assessed. The patient’s abdomen should also be A vaginitis. This can usually be confirmed by a examined, to determine whether the clinical speculum examination. signs support the diagnosis of placenta praevia.
  • 17. 116 MATERNAL CARE 3. How can the cause of the vaginalis is presumed to be the cause of the vaginitis be determined? vaginitis. During the speculum examination, a sample of the discharge should be taken and a wet smear 5. How should you treat a patient made. Organisms seen on the wet smear are with Trichomonal vaginitis? probably the cause of the vaginitis. A single dose of 2 g metronidazole (Flagyl) is given orally to both the patient and her 4. What is the most likely cause of a partner. Both must be warned against vaginitis with a blood-stained discharge? drinking alcohol for a few days after taking metronidazole. Trichomonas vaginalis. Therefore, if a microscope is not available, Trichomonas