This document summarizes findings from the Danish Oxygen Register regarding long-term oxygen therapy (LTOT) in Denmark from 1994-2000. Some key findings include: - The prevalence and incidence of COPD patients on LTOT increased and reached a plateau around 25 and 40 per 100,000 respectively. - There was an increase in the proportion of cancer patients, older patients, and those using mobile oxygen units starting LTOT. The percentage treated over 15 hours daily and after hospital admission also rose. - Around 20-25% of COPD patients on LTOT were still smoking despite the therapy. - Survival rates improved over the period, however remained lower than other countries due to higher 6-

1. LTOT i Danmark 1994-2000
Thomas Ringbæk, Hvidovre Hospital
Peter Lange, Hvidovre Hospital

2. Fokus områder
Diagnoser
Prævalensen
Incidensen
Patient-karakteristika: alder, køn
Behandlingskvaliteten: >15 timer dagligt
tobaksrygning
ambulant kontrol
Iltudstyr
Overlevelse

3. Dansk Iltregister siden
november 1994
Iltleverandører vedr. 98-99% alle patienter
Spørgeskema vedr. nystartede i 1995
Journaler vedr. diagnose, medicinering,
blodgasser, htc., EKG/EKKO og tobak
Centrale registre: Vital status, kontakter med
sundhedsvæsenet

4. Prævalens af LTOT 1994-2000
0
10
20
30
40
50
60
70
80
31.10.94 31.12.95 31.12.96 31.12.97 31.12.98 31.12.99 31.12.00
per100.000
Missing
Others
Cancer
COPD

5. Incidens af LTOT 1995-2000
0
10
20
30
40
50
60
70
1995 1996 1997 1998 1999 2000
per100.000
Missing
Others
Cancer
COPD

6. Ændringen i iltordination og patient-
karakteristika fra 1995 til 2000
0
10
20
30
40
50
60
70
80
90
1995 1996 1997 1998 1999 2000
%
Initiated after
admission
Outpatient clinic 1-6
months after start
Started by GP
0
10
20
30
40
50
60
70
80
90
1995 1996 1997 1998 1999 2000
%
15-24 hrs/day
Age>70 yrs
Mobile oxygen
0
10
20
30
40
50
60
70
01.11.9431.12.9531.12.9631.12.9731.12.9831.12.9931.12.00
%
Females
Age>70 yrs
Flow >1.5 L/minute
0
10
20
30
40
50
60
70
80
90
100
01.11.9431.12.9531.12.9631.12.9731.12.9831.12.9931.12.00
%
Oxygen
concentrator or
liquid oxygen
15-24 hrs/day
Mobile oxygen

7. Smoking status of COPD patients, residing in the central part of
Copenhagen, and on LTOT in 1995 and 2000, respectively.
1995
n=240
2000
n=279
P-level for
difference
Asked about smoking
Admitted smoking (% of
asked patients)
180(75.0%)
34(20.4%)1
216(77.4%)
32(15.5%)2
0.52
0.23
Measured CO
Abnormal value
(% of checked patients)
136(56.7%)
21(15.4%)
141(50.5%)
19(15.8%)
0.16
0.64
Asked about smoking or
measured CO-level
Indication of smoking
(% of asked or checked)
187(77.1%)
47(25.1%)
222(79.6%)
47(21.2%)
0.65
0.34
1) 13 cases of “don’t know” 2) 10 cases of “don’t know”

8. Survival rates of new COPD patients on LTOT from
Denmark compared to patients from other countries
0
10
20
30
40
50
60
70
80
90
100
0 3 6 9 12 15 18 21 24 27 30 33 36 39
months
cumulativesurvivalproportion(%).
Denmark (n=5659)
Sweden (n=403)
Belgium (n=270)
France (n=252)
Australia (n=505)

9. Survival of COPD patients who
started LTOT in 1995 versus 1999
0,00 0,50 1,00 1,50 2,00 2,50 3,00 3,50 4,00 4,50 5,00 5,50 6,00
Years
0,0
0,2
0,4
0,6
0,8
1,0
CumSurvival
Year of start
1995
1999
Median
1.07 vs
1.40 yrs;
p=0.032

10. Konklusion
↑ Andel af patienter med cancer
↑ Incidens og prævalens af KOL -
nået plateau omk. 25 og 40 per 100.000
↑ Mobil-ilt, ↑ starter efter indl. og ↑ alder
↑ ”15-24 timer/dag”
Kun ca. 50% følges i medicinsk amb.
Mindst 20-25% ryger
Dårligere overlevelse end udlandet pga.
meget højere 6-måneders mortalitet
↑ Overlevelse