This study assessed the psychosocial factors associated with childlessness among couples in Gubre town, Ethiopia. It found that 45% of respondents reported experiencing high levels of psychological problems due to childlessness, while 70% received little psychosocial support. Regarding discrimination, 55% reported experiencing little discrimination. The study concluded that couples in Gubre town experienced high levels of psychological impact from childlessness, low levels of social support, and some experienced discrimination due to their inability to have children.