Presentation given in 2015 : How much does litigation affect our practice of using assisted reproductive technologies for the management of infertility? What do we know and what are the issues surrounding this technology?
The five most frequently-occurring and most stressful ethical and patient care issues were protecting patients' rights; autonomy and informed consent to treatment; staffing patterns; advanced care planning; and surrogate decision-making.
Patients for patient safety. Margaret Murphy. III International Conference on Patient Safety: "Patients for Patient Safety" (Madrid, Ministry of Health and Consumer Affairs, 2007)
The five most frequently-occurring and most stressful ethical and patient care issues were protecting patients' rights; autonomy and informed consent to treatment; staffing patterns; advanced care planning; and surrogate decision-making.
Patients for patient safety. Margaret Murphy. III International Conference on Patient Safety: "Patients for Patient Safety" (Madrid, Ministry of Health and Consumer Affairs, 2007)
Do Not Resuscitate Orders : What They Mean ?SMSRAZA
Most doctors working in Acute areas know when and how to do CPR. However, most get stuck when it comes to ' When not to do CPR' due to cultural, social, ethical and legal issues attached.
an insight on medical negligence and certain techniques that can be adopted to ensure that such errors or mistakes can be avoided. Deliberately or not we must always ensure that proper healthcare is provided and received.
Research in the Patient Safety Strategy. David Bates. IV Internacional Conference on Patient Safety (Madrid, Ministry of Health and Consumer Affairs, 2008)
Do Not Resuscitate Orders : What They Mean ?SMSRAZA
Most doctors working in Acute areas know when and how to do CPR. However, most get stuck when it comes to ' When not to do CPR' due to cultural, social, ethical and legal issues attached.
an insight on medical negligence and certain techniques that can be adopted to ensure that such errors or mistakes can be avoided. Deliberately or not we must always ensure that proper healthcare is provided and received.
Research in the Patient Safety Strategy. David Bates. IV Internacional Conference on Patient Safety (Madrid, Ministry of Health and Consumer Affairs, 2008)
Midlevel Operations: Exploring New Expsoures with Allied Health ProvidersSedgwick
Jayme T. Vaccaro, J.D.
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this presentation is all about the ethical issues that the orthodontists face, along with the well written informed consent and guidelines that an orthodontist needs to follow.
The community and patients tend to forget that the clinicians and other healthcare personnel are also human like them. Every human makes an error while performing his or her task, accurately reporting the performance and due to general forgetfulness. However, the consequences of errors in medical practice are potentially serious for both patients and doctors alike.
A presentation given in 2016 on our unit's journey through time - its establishment, our strengths - people and public support.
We also discuss various treatments offered here - their technical details and scientific information in the same presentation
Presentation given in 2018 on Endometriosis - management in the infertility setting. When are assisted reproductive technologies used and what are the medications used for dealing with this condition?
Intra uterine insemination (IUI) to Invitro Fertilization (IVF): When to move...Anu Test Tube Baby Centre
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Presentation given in 2016 on protocols used for ovarian stimulation when undertaking in vitro fertilization (IVF) for management of infertility when using assisted reproductive technologies.
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Presentation given in 2017 on how to overcome difficulties one may face when undertaking embryo transfers during assisted reproductive technologies (Invitro fertilization - IVF) (ICSI)
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Presentation given in 2017. Management of infertility using assisted reproductive technologies.
What is the role of antagonist in IUI and IVF - tips and tricks to optimize its use.
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Ovarian Hyperstimulation Syndrome (OHSS) - causes, diagnosis and management of this condition.
How to minimize its risk and what are the related practice guidelines?
Optimal protocols for Ovulation induction (Assisted Reproductive technologies)Anu Test Tube Baby Centre
Presentation given in Tirupati, India in 2018 on Ovulation Induction for assisted reproductive technologies. Dealing with infertility using Intra uterine insemination (IUI) and In vitro fertilization (IVF)
Algorithms for Ovulation induction protocols (Assisted reproductive technolog...Anu Test Tube Baby Centre
Algorithms for ovulation Induction during Assisted Reproductive Technologies for treating infertility. Intrauterine Insemination (IUI) and In vitro Fertilization (IVF)
What is Polycystic Ovarian Syndrome? Hormonal evaluation, diagnosis and treatment and its relation to infertility. How does one manage PCOS in an infertility setting?
Ovulation induction protocols for unexplained infertility new advances 2019 f...Anu Test Tube Baby Centre
What are the new advances in assisted reproductive technologies with respect to ovulation induction for unexplained infertility ? - Intra uterine insemination (IUI) and in vitro fertilization (IVF)
How does one increase the chances of success when carrying out intra uterine insemination (IUI) procedures in places carrying out assisted reproductive technologies (ART)?
Slideshow on Unexplained infertility presented in 2009 - treatment options, diagnosis and more. Assisted reproductive technologies and its details
Discussion of IUI, IVF and other infertility treatment options
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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2. Objective
How to avoid litigations
What to do when things go wrong
To identify the aspects of ART that are
most relevant to „present - day society‟
To discuss the multiple ethical, legal &
social challenges inherent to the
technology
4. Litigations in our practice
Reputation for being a highly litigous
speciality
In USA :-
Annually 11 % obst. & Gyn. face
malpractice suit
2.5 % result in pay out
100 % of obst. & Gyn. Over their medical
career -
Face a claim for medical negligence
5. Time limit for claims
Gynaecology -
Within „3 yrs‟ of injury or
date of knowledge of clinical negligence
Child -
3 yr period reach after their 18th birthday
i.e, until their 21st birthday
In birth injuries -
„ No time limit‟ applies, who lack capacity
Adult death -
With in 3 yrs of date of death
6. Why do doctors get sued ?
Accountability
• When things go wrong someone should be
held accountable for their actions
The need for an explanation
• To know how the injury happened & why
Concern with standards of care :
• The desire to prevent similar accidents in
future
Compensation
• For actual losses, pain & suffering or
• Provision of future care for an injured person
7. Deciding factors for legal action
Failure to provide information and
explanation & an apology
Insensitive handling of injury &
Poor communication after the
original incident
8. Anatomy of a claim
Medical defence organizations – receive several
thousand new claims / yr
Few, 1-2 % reach court
70 % chance that cases are successfully defended
Irrespective of outcomes, being sued is a
distressing experience
Usually 3 yrs. From the point a claim is made for the
case to reach a courtroom
11. Elements of compensation award
Financial compensation :
„General damages‟
• Pain & suffering caused by the injury
• This includes an element to represent
personal inability to do things before the
incident
• Assessed using guidelines given to judges
and precedents from previous cases
12. „special damages‟
• Compensation is for past and future
losses and expenses
Most often, clinical negligence cases are
settled out of court
13. Aetiology of claims
A case of clinical negligence requires four
elements are met:
• Duty arising out of the physician –
patient relationship
• A breach of that duty
• A link between that breach of duty, &
• A specific harm that has occured
14. Common areas of litigation in
Gynaecology
Common cause of claims, 2012
Wrong / failed / delayed diagnosis
Inappropriate / failed / delayed
treatment
Intraoperative problems
Failure to obtain informed consent
Failure to recognise complication
Failure to perform operation / tests
Foreign body left in situ
Others
Claims by injury
Bladder damage / fistula
Unnecessary pain
Additional/unnecessary
operation(s)
Bowel damage / dysfunction
Cancer
Psychiatric / psychological damage
Perforation
Others
16. Consent
Most patients are healthy with problems relating to
quality of life
Most surgery is elective
Expectations of the patients
• Are high and
• Litigation is often related to whether these are met
Signature on a consent form does not equate to
valid consent
The purpose is to record the patient‟s decision and
also the discussions that have taken place
17. • Ensure she understands –
the nature of the condition -
its prognosis, -benefits and risks inherent to
the procedure
• Likely consequences and risks
• Risks of receiving no treatment
• Realistic expectations following surgery
• Reasonable or accepted alternative treatments
18. „critical element‟ of an informed decision
• Discussion of the risks associated with
a clinical decision
• Uncertainties should be discussed
Performance of procedures that were not
discussed with the patient;
i.e, removal of both ovaries when
consented for one or none
19. Common procedures for litigation
Sterilization –
conception
post
sterilization
Laparoscopy
Colposcopy
• Physician
errors or
• Laboratory
errors
Hysteroscopy
Urogynaecology
• Increasingly, centred on the use of
meshes & related complications
Hysterectomy
• Ureteric injury most common cause –
failure to detect
Foreign body – (SUIs)
retained foreign bodies are – classified
as serious untoward incidents,
result in a payment of negligence
claims
20. Laparoscopy
Allegation of a lack of training, lack of expertise or
wrong choice of surgery
Most common cause is internal injury or delay in
recognition
„Difficult‟ to defend –
• Improper documentation
• Inappropriate management & monitoring
Laparotomy – patients should improve on a daily basis,
• In laparoscopic surgery; should on hourly basis
• Patients expectations should be fully met &
o Early recognition of warning signs
21. Recommendations to avoid
complications
Best possible vision maintained
at all times
Avoid use of sharp instruments
unless absolutely
necessary
Use of diathermy, ultrosonic
devices
• Require knowledge of their use
and utmost care
Rule out bowel injury after
primary trocar insertion
Check all areas of tissue
injury or bleeding on
completion
All trocar sites should be
inspected
Use a drain when
necessary
Appropriate contact
details need to be
given
22. Hysteroscopy
Litigation related to
• Failure of clinicians to adapt to the
demands of newer technologies
• Lack of adequate expertise when
performing complicated procedures
• Failure to recognise complications
during relatively simple procedures
23. Complications related to uterine perforation
& subsequent internal organ injury
Commonest cause is the failure to recognize
complication
Clinical negligence claims
24. Hysteroscopy
Factors that increase perforation risk
• Cervical stenosis
• Ac. Av / Rv
• Lower segment fibroids
• Intrauterine synechiae &
• Operator in experience
25. Hysteroscopy
„Red alert‟ – (Fatal complications)
• Fluid overload – causing Hyponatraemia
respiratory arrest & seizures
• Air-embolism: leading to collapse & death
27. Good documentation
Old saying „if it‟ is not in the record,
It didn‟t happen,
Still hold true
Good record keeping :
• Information provided by the patient that lead to
diagnoses or treatment decisions,
• The physical findings or laboratory results that
factored into decisions,
• Treatment selected
• Anticipated follow-up
29. Good communication
More important than high standards of care
A valid informed consent
• Is a „dialogue‟ , not a lecture
• To discuss
Risks of treatment
Benefits of treatment
Alternatives to treatment
Including nothing &
Pros & cons of treatment
31. Accurate representation
A doctor‟s greatest assest is their
advanced training & experience,
but imp. to work with in that remit
Imperative not to misrepresent their
experience
Give patients, realistic expectations
about their outcomes
32. Discharge Instructions
More procedures as day cases & inpatient stay
shorter
Should address all areas of potential concern,
including pain, wound care & signs of
infection
Information regarding contact details in case of
a query or emergency
34. Saying sorry
Doctors are human
• Errors sometimes happen
Taking responsibility
doesn‟t mean admitting negligence
Acknowledge a complication & minimise
consequences
• May involve transferring care to another physician
When things go wrong :
vast majority want an explanation & an apology
37. Ethical issues
73 % feel practice is defensive for fear of
litigation
Additional & unnecessary tests are performed
These can be invasive & potentially harmful for
the patient
Drives up the health care concepts
38. Ethical issues …..
Impact on the health care professional
A malpractice suit has same impact as
• A major illness
• Loss of a loved one
• or a severe career set back
• Additional emotional consequences & involves
stages of grief
• Can cause irritability, headache, insomnia,
difficulty with concentration, clinical
depression & suicide
39. Ethical issues ……….
Increasing reluctance to join specialities
prone to litigation
• Obst. & Gyn. Is one of these
Deterrant for doctors to assist people in
emergency situations
40. Direct conflict of professional obligations &
a reluctance to be involved in a situation that
can land the clinician in a court room
41. Conclusion
In spite of the
best intentions,
high standards of care, &
attention to all issues discussed,
litigation claims may still be made
Individual awareness & adequate support
• Is the basis of coming through these stressful
situations &
• Keeping one‟s enthusiasm & zeal for continuing in
the profession intact
42.
43.
44. * To identify the
aspects of ART
that are most
relevant to
„present-day
society‟
* To discuss the
multiple ethical,
legal & social
challenges
inherent to the
technology
Object
-ive
45.
46. Scope of ART Utilization
Explosion of IVF availability & use
More than 70 million couples with infertility,
worldwide
Use of ART services increased at a rate of 5 - 10 %
annually
USA 1996
• 60,000 IVF cycles
17,000 clinical preg.
14,000 live births
• Currently 1 % of all live births
47. Reporting Regulations
Legislation & professional societies attempt to
address the concerns
In 1980, focus on safe administration of
Gonadotrophins
Transparency of pregnancy data
Addressing economic barriers to ART access
Reporting ART
(like no. of ET, in USA)
but no accompanying legislation defining
practice patterns
48. Centralized mandatory reporting registries
General estimate of IVF activity
• To define current IVF statistics
• Take make information more transparent &
available
Fertility clinic success rate & certification act,
1992 – USA
HFEA
IFFS – detailed accounting for ART reporting &
regulations across the globe
In 2010, - ART outcome data from 59
countries
54. CBRC
(cross-border reproductive care)
• Variability of legislation regulating IVF
in different countries & even with
in a single nation
• 10 % of total IVF cycles
55. Financial aspect for IVF
treatment
One of the most obvious ethical
challenges
Inequitable distribution of access to care
Significant economic barriers to IVF in
many countries
56. Highly variable funding structure
• USA –
o No federal Govt. funding
o Insurance mandate in certain states
• Many countries -
full or partial coverage
• Long waiting lists
• UK; 25 % of IVF cycles – funded by NHS
57. Pre-Implantation genetic
testing
PGS & PGD
• Offer unique ability to
„characterize
genetic composition‟
of embryos
Likely broader
implementation in future
58. PGS for sex-selection
• Controversial
• May offer substantial health benefit to
avoid sex-linked disorder
• Preferential PGD
May skew the gender proportions
59. Regulations to prevent tampering of the
scientific advances
• „Designer babies‟
Refinement of microarray technologies to
define genetic sequences associated
with certain physical or mental
characteristics
• Manipulation of genetic material with in an
embryo
• Concerns on ethical & practical levels
Pre-Implantation genetic
testing (cont.)
60. Fertility preservation
Fertility declines with age
Oocyte cryopreservation
Before advanced age
For individuals affected with cancer
o Chemotherapy toxic to ovary
Techniques for freezing sperm & embryos
are well established
61. Lower pregnancy rates
• Oocyte cryopreservation using IVM
• Preservation of ov. cortex strips with
subsequent reimplantation & stimulation
Fertility preservation measures
• Should be offered before cancer treatment
Poses financial, ethical & social issues
62. Oocyte donation
• Introduced in 1980
• Visible increase
• Donor need to undergo IVF
Inherent risks
• Medical, OHSS,, Surgical
Informed consent & counselling
• Donor should participate voluntarily
• Financial compensation
May lead to exploitation
• „buying or selling‟ of gametes-immoral
Maintaining „anonymity‟ of Donor -
ability of human beings to know
their genetic roots is
universally important
Right of Donor & Offspring to meet &
develop relationship – may
become more visible in the future
Use of Donor gametes
common place in ART
Donor sperm
Donor oocytes
Sperm donation
Can be traced to 1800
Gamete
donation
63. Embryo Donation
Ovarian stimulation –
Transfer of several embryos &
Cryopreserving other embryos
Surplus embryos –
Sometimes never used by genetic parents
Stored indefinitely
Nearly 4oo,ooo embryos currently cryopreserved
Dealing with these involve ethical & social
issues
Possible fate -
1. Thawing & discarding
2. Donating to research
3. Indefinite storage
4. Donating another couple
Myriad of laws governing -
Fierce debate relating to human stem cells
Varied laws from nation to nation
64. Surrogacy & gestational carriers
Surrogate –
pregnancy using her own oocyte
but sperm of another couple
Gestational carrier
• Carrier of couple‟s genetic
gametes
• More common
Significant medical &
emotional risks
• Extensive counselling
• Meticulous informed consent
• Concerns of “ child-selling” or
“sale of parental rights”
• Rights of birth mother,
regardless of genetic relation
Exploitation &
commoidification of
services
• Because of financial
pressures
International – surrogacy
• Emerging industry in
developing nations
• Difficult ethical l& legal
issues
• Citizenship issues of
offspring
• Largely unresolved
internationally
65. Possible deleterious effects of ART
Questions & concerns regarding IVF
Conflicting data on risks of IVF on developing
embryo
66. Multiple studies – failed to find clinically
relevant association bet. IVF,
embryo cryopreservation &
adverse maternal & fetal effects
Small but statistically significant
increased risk for rare epigenetic
& other abnormalities
67. General consensus –
small but measurable increased risk for
variety of congenital abnormalities –
including anatomic abnormalities &
imprinting errors
This may be secondary to increased baseline
risk
But, small increased risk may not be enough
powerful factor to dissuade infertile
couples
68. Conclusion
One of the most widely adopted and successful
medical technologies, in the last century
Present new ethical, legal & social questions that
society must address
Dynamic & ever changing
New technologies raise more controversies &
debates
Physicians to continually monitor these issues &
ensure that ART technologies are offered &
delivered in a manner that balances patients
care with social & moral responsibility
“ primum-non-nocere” first-do-no harm