Lisa Salvador is a pharmaceutical research professional with over 10 years of industry experience focusing on clinical biomarkers, translational medicine, and drug development. She has a PhD in Cell Biology from Northwestern University and has held senior research roles at Bristol-Myers Squibb and GlaxoSmithKline. Her expertise includes cellular and molecular biology, gene therapy research, and diagnostic assay development. She has received numerous awards for her research contributions and leadership.

1. Lisa M. Salvador, PhD
202 Willow Wood Drive
Doylestown, PA 18901
Mobile: 215-704-7985
Email: salvador.lisa@gmail.com
SUMMARYOF QUALIFICATIONS
 Pharmaceuticalresearch and development professional with over 10 years industry experience
 Experienced researcher in the areas of clinical biomarkers, translational medicine and drug development
 Strong scientific expertise in cellular and molecular biology, gene therapy research and diagnostic assay
development
 Strong communication, matrix leadership and stakeholder management skills with managerial and matrix
team leadership experience
 Experience in all phases of pharmaceutical development including discovery, early clinical development
through Phase III and post marketing R&D.
 Experienced with health authority interactions (e.g. FDA and EMA),preparation of IND filings, crafting
clinical development strategies, clinical protocol development and implementation.
 Extensive experience with external key opinion leader interactions, scientific advisory boards and external
collaborations with CROs,vendors, and academia partners.
EDUCATION
 Postdoctoral Fellowship  University of Pennsylvania, 2003-2007, Philadelphia, PA
Focus: Embryonic Stem Cell Biology/ Molecular Biology
 PhD,Cell Biology  Northwestern University, 2003, Chicago, IL
Focus: Cellular and Molecular Biology / Pharmacology
 B.S., Molecular Biology and Chemistry  University of Pittsburgh, 1997, Pittsburgh, PA
Focus: Chemistry/Biochemistry and Molecular Biology
PROFESSIONAL EXPERIENCE
SENIOR RESEARCH INVESTIGATOR II
Cardiovascular Clinical Biomarkers; Early Clinical and Translational Research (ECTR)
September 2008-present  Bristol Myers-Squibb, Hopewell, NJ
 Clinical Biomarker and Translational Medicine Strategy development and implementation in all areas of drug
development from early discovery to Phase III in Heart Failure, Gene Therapy, Diabetes,Thrombosis, Renal
Disease and Atherosclerosis therapeutic areas.
 Strong communication, matrix leadership and stakeholder management skills. Work is focused on
coordination and collaboration of biomarker efforts across BMS departments and with external partners
including CROs,vendors, KOLs and clinical sites.
 Collaboration with Cardiovascular Drug Discovery and Early and Full Clinical Development Teams to
coordinate clinical and biomarker strategy together with implementation and operational strategies for
biomarkers in clinical trials.
 Preparation of translational budget proposals, ECN documents, clinical protocols, clinical development plans,
lab testing and sample management plans, statistical analysis plans, clinical study reports, informed consent
forms, investigator brochures and data tables, graphs and listings.
 Leadership of Translational R&D teams focused on exploring target gene and protein expression and
pharmacodynamic biomarker development strategies in both animal models and clinical samples,

2. development of diagnostic assays for gene therapy programs, identification of novel biomarkers and
biomarker platforms for heart failure programs and patient stratification strategies for heart failure assets
 Managed one/two employees, overseeing their daily activities.
PRINCIPAL SCIENTIST
Cardiovascular and Urogenital Discovery Technology Group
January 2007-September 2008  GlaxoSmithKline, King of Prussia, PA
 Cardiovascular Research focused on the use of stem cells in cardiac regeneration, vascular biology and heart
failure treatments.
 Designed and executed specific cell based assays using stem/progenitor cells and primary cells for cardiac
programs within GSK.
 Utilized RNAi, High Content Imaging and in vitro differentiation assays to analyze the effects of various
compounds on cardiovascular function.
 Worked closely with CVU Strategy and Business Development to coordinate severalindustrial and academic
external collaborations and in-licensing agreements.
 Managed two employees, overseeing their daily activities and experiments.
POSTDOCTORAL RESEARCHER  Diabetes
June 2006-January 2007  Children's Hospital of Philadelphia and University of Pennsylvania-Center for
Research on Reproduction and Women's Health, Philadelphia, PA
 Diabetes research focusing in insulin secretion signal transduction pathways.
 Designed and executed experiments testing the effects of exendin-4 and exendin-9 on gene transcription in
islet cells.
 Utilized CHIP assays,siRNA and QPCR to analyze the effects of insulin, insulin effectors and glucose on
downstream gene targets in islet cells, hepatocytes and adipose tissue in rats.
POSTDOCTORAL FELLOW - Stem Cell Research
June 2003 to June 2006  University of Pennsylvania - Center for Research on Reproduction and Women’s
Health, Philadelphia, PA
 Stem Cell Biology and Infertility Research focusing on germ cell derivation from embryonic stem cells.
Utilized gene marker expression in ES cells to generate ES cell lines containing fluorescent markers of male
and female germ cells.
 Designed and developed cell culture conditions to generate male and female germ cells from mouse
embryonic stem cells.
 Use of confocal microscopy to analyze and characterize ES cell differentiation.
 Development of technology for GFP and DsRed fusion proteins to track germ cell development in the
mouse.
GRADUATE STUDENT  Cell Biology and Signal Transduction
April 1998-April 2003  Northwestern University-Feinberg School of Medicine, Chicago, Illinois
 Isolated and identified a novel ovarian protein, AKAP 80 present in rat granulosa cells.
 Performed In vivo and in vitro analysis of signal transduction pathways downstream of G-protein coupled
receptors present in ovarian follicles.
 Utilized cell culture and tissue culture in addition to immunofluorescence and immunohistochemistry to
study the biology and biochemistry of ovarian proteins.
 Teaching assistant for Biochemistry and Signal Transduction classes.

3. RESEARCH PUBLICATIONS
Kirchgessner TG, Sleph P, Ostrowski J, Lupisella J, Ryan CS, Liu X, Fernando G, Grimm D, Shipkova P,Zhang
R, Garcia R, Zhu J, He A, Malone H, Martin R, Behnia K, Wang Z, Barrett YC, Garmise RJ, Yuan L, Zhang J,
Gandhi MD, Wastall P, Li T, Du S, Salvador L, Mohan R, Cantor GH, Kick E, Lee J, Frost RJ. (2016)
Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating
Neutrophils. Cell Metab. Aug 9:24(2):223-33.
Salvador, L.M.,Silva, C.S., Kotetskii, I., Radice, G.L., and Strauss J.F, III. (2008) The Promoter of the Oocyte-
specific gene, Gdf9, is Active in a Population of Cultured Mouse Embryonic Stem Cells with an Oocyte-like
Phenotype. Methods. Jun; 45(2):172-81
Silva C.S.,Wood J.R., Salvador L.M., Kotetskii I., Williams C.J.,and Strauss J.F., III. (2008) Expression Profile
of Male Germ Cell-Associated Genes in Mouse Embryonic Stem Cell Cultures Treated with All-Trans Retinoic
Acid and Testosterone. Mol Reprod Dev. April 18.
Silva C.S., Salvador L.M,and Strauss J.F.,III. (2006) Differentiation of germ cells from stem cells. Stem Cells
in Reproductive Medicine. p. 16-30.
Salvador, L.M. and Strauss J.F.,III. In Vitro Development of Germ Cells. Proceedings of the Sapporo 6th
International Symposium on Ovarian Function.
Salvador, L.M.,Flynn, M.P.,Avila, J., Reierstad, S., Maizels, E.P.,Alam, H., Park,Y., Scott, J.D.,Carr, D.W.,
and Hunzicker-Dunn, M. (2004) Neuronal Protein Microtubule-Associated Protein 2D (MAP 2D) is a dual A-
kinase anchoring protein expressed in rat ovarian granulosa cells. J. Biol. Chem. 279(26): 27621-32
Salvador, L.M.,Carr, D.W.,Avila, J., Park,Y., Reierstad, S., Scott, J.D.,and Hunzicker-Dunn, M. (2003)
Neuronal Protein Microtubule-Associated Protein 2D (MAP 2D) is a Protein Kinase A RI (PKA RI) Binding
Protein and a Functional A-kinase Anchoring Protein (AKAP) in Rat Ovarian Granulosa Cells. Endocrine
Society 85th Annual Meeting-Oral Abstract
Cottom, J.E., Salvador, L.M.,Maizels, E.T., Reierstad, S., Park,Y., Carr, D.W.,Davare,M.A.,Hell, J.W.,
Palmer, S.S., Dent, P.,Kawakatsu,H.,Ogata,M., and Hunzicker-Dunn, M. (2003) Follicle Stimulating Hormone
Stimulates Activates Extracellular Signal Regulated Kinases but not Extracellular Signal Regulated Kinase
Kinase through a 100 kDa Phosphotyrosine Phosphatase. J. Biol. Chem. 278(9): 7167-79
Salvador, L.M.,Cottom, J.E., Maizels, E.T., Carr, D.W., and Hunzicker-Dunn, M. (2002) The 80 kDa A-Kinase
Anchoring Protein Induced by FSH in Ovarian Granulosa Cells corresponds to MAP 2D. Endocrine Society 84th
Annual Meeting-Abstract.
Salvador, L.M.,Carr D.W.,and Hunzicker-Dunn, M. (2003) Neuronal protein microtubule-associated protein
2D (MAP 2D) is a functional A-kinase anchoring protein (AKAP) in ovarian granulosa and luteal cells. 35th
Annual Meeting of Society for the Study of Reproduction-Oral Abstract.
Salvador, L.M.,Maizels, E.T.,Hales, D.B.,Miyamoto, E., Yamamoto, H., and Hunzicker-Dunn, M. (2002)
Acute Signaling by the Luteinizing Hormone (LH) Receptor is Independent of Protein Kinase C Activation.
Endocrinology 143(8),2986-2994.
Salvador, L.M.,Mukherjee, S., Kahn, R.A.,Rasenick, M.M., Casanova,J.E., and Hunzicker Dunn, M.
(2001) Activation of the Luteinizing Hormone/Choriogonadotropin Hormone Receptor Promotes Activation of
ADP Ribosylation Factor (ARF) 6 in Porcine Ovarian Follicular Membranes. J Biol Chem. 276(36):33773-33781
Salvador, L.M.,Park,Y.,Cottom, J.E.,Maizels, E.T., Jones, J. C. R., Schillace, R. V. Carr,D. W., Cheung, P.,

4. Allis, D.C.,Jameson J.L. and Hunzicker-Dunn, M. (2001) Follicle-stimulating Hormone Stimulates Protein
Kinase A-mediated Histone H3 Phosphorylation and Acetylation Leading to Select Gene Activation in Ovarian
Granulosa Cells. J Biol Chem. 276: 40146-40155.
Salvador, L.M., Cottom,J.E., Maizels E.T.,Ogata M., and Hunzicker-Dunn M. (2001)
FSH Activates MAPK/ERK via a Protein Kinase A-Dependent,MEK-Independent pathway in Rat Ovarian
Granulosa Cells. Endocrine Society 83rd Annual Meeting-Abstract
Salvador, L.M.,Maizels E.T., Hunzicker-Dunn, M. (2000) LH-Induced Phosphorylation of MAPK is PKA
dependent. Endocrine Society 82nd Annual Meeting-Abstract
Carr, D.W., Cutler Jr.,R.E., Cottom, J.E., Salvador, L.M.,Fraser,I.D.C.,Scott, J.D.,Hunzicker-Dunn, M. (1999)
Identification of PKA Holoenzymes in Preantraland Preovulatory Follicle-Enriched Ovaries and their
Association with A-Kinase Anchoring Proteins. Biochem. J. 344: 613-23.
Willis, S.H., Rux, A.H.,Peng, C., Whitbeck, J.C.,Nicola, A.V.,Lou, H.,Hou, W., Salvador, L., Eisenberg, R.J.,
Cohen, G.H. (1998) Examination of the kinetics of herpes simplex virus glycoprotein-D binding to the
herpesvirus entry mediator (HVEM),using surface plasmon resonance. Journal of Virology 72(7):5937-47.
Pierce,J.C.,Maloy, W.L., Salvador, L., Dungan, C.F. (1997) Recombinant expression of the antimicrobial
peptide polyphemusin and its activity against the protozoan oyster pathogen Perkinsus marinus. Molecular
Marine Biology and Biotechnology. 6(3):248-259.
HONORS AND AWARDS
 Robert H. Lurie Cancer Center BaseballCharities Fellowship  1999
 U.S. Army Breast Cancer Training Grant  2000
 Northwestern University Endo Diabetes & Hormone Action NRSA Training Grant  2001 to 2003
 Cellular and Molecular Biology of Reproduction and Endocrinology Training Grant  2003 to 2006
 GSK Recognition Award: Bronze Level  2007
 BMS BioPharma Behaviors Award: Connect and Collaborate 2011
 BMS R&D Team Award:11bHSD-1 Knowledge Integration Matrix Team Award  2012
 BMS R&D Star Award: Diabetes Biomarker Strategy  2012
 BMS R&D Star Award: Heart Failure Strategy  2013
 BMS R&D Star Award: Execution of TR&D Projects  2014
 BMS R&D Star Award: MPO biomarker support  2014
 BMS R&D Star Award:TR&D support  2015