The document discusses using the RGD epitope found in engineer "Arg-Gly-Asp" to display on virus-like particles formed from tobacco mosaic virus (TYMV) in order to target cancer cells that up-regulate integrin. It describes mutating the internal scaffold N-terminus of the TYMV coat protein and substituting RGD at residue 44 to form pH-dependent stable particles. It also discusses expressing GFP and GUS from dual subgenomic RNA of TYMV for potential vaccine development and using the particles as nano-inspired containers with applications in biophysics, crystal structure determination, and signaling studies of cytomegalovirus.