This document provides guidelines for hydraulic calculations and line sizing for process plants. It outlines the general approach to hydraulic calculations, including pressure drop criteria, equivalent lengths of valves and fittings, and flow regimes for vapor-liquid mixed phase flow. Tables with typical line sizing criteria are included for liquid, vapor, gas and two-phase flow lines. Special considerations and calculation methods are described for thermosyphon reboiler circuits, kettle reboiler circuits, pump NPSH, and vacuum tower transfer lines. Appendices provide references and additional tables and figures to support the guidelines.