We've long wondered if we're along in the universe. There's more and more tantalizing hints that we might not be alone in our own solar system. The default assumption is that those "hints" are weird chemistry or bad measurements or modeling, but if that's not the case, what then?
Life, the Universe, andSETI in a NutshellSérgio Sacani
Todate,no
SETI
observing
program
hassucceededindetectinganyunambiguousevidenceofan
extraterrestrial
technology.Regrettably,
this
paper
willtherefore
not
dazzleyou
with
the
analysisof
the
contentsofanyinterstellarmessages.However,asis
appropriate
foraplenarypresentation,
this
paper
doesprovidean
update
on
the
state
of
SETI
programsworldwide.Itdiscusses
the
various flavors ofobservational
SETI
projectscurrentlyon
the
air,plansforfutureinstrumentation,recent
attempts
toproactively
plan
forsuccess,
andthe
prospectsforfuture
public/private
partnershipstofundtheseefforts.
Thepaper
concludes
with
some
tentative
responsesto
the What
ifeverybodyislistening,
and
nobodyis
transmitting?
query.
Planet Labs is making use of information gathered from space to help with life on Earth. The group of scientists considered
the problem with most satellites to be their large and clunky form, prompting them to build inexpensive and compact satellites to be manufactured in bulk, called CubeSats.
How Brands Can Survive & Thrive Online - Digital EvolutionAndrea Vascellari
Andrea Vascellari's presentation about "digital evolution" and how "digital species" - in this case websites & web properties of brands and organizations - need to adapt to environmental changes (new technologies, etc...) or else they will be wiped off the face of the world wide web.
Head in the clouds: Engaging with the web for archaeologistsdavstott
This presentation was given on 22nd of september 2011 at the Aerial Archaeology Research Group (AARG) in Poznan, Poland.
It explores how archaeologists could exploit citizen science collaborations to make better use of the ever proliferating quantity of aerial and satellite data.
Life, the Universe, andSETI in a NutshellSérgio Sacani
Todate,no
SETI
observing
program
hassucceededindetectinganyunambiguousevidenceofan
extraterrestrial
technology.Regrettably,
this
paper
willtherefore
not
dazzleyou
with
the
analysisof
the
contentsofanyinterstellarmessages.However,asis
appropriate
foraplenarypresentation,
this
paper
doesprovidean
update
on
the
state
of
SETI
programsworldwide.Itdiscusses
the
various flavors ofobservational
SETI
projectscurrentlyon
the
air,plansforfutureinstrumentation,recent
attempts
toproactively
plan
forsuccess,
andthe
prospectsforfuture
public/private
partnershipstofundtheseefforts.
Thepaper
concludes
with
some
tentative
responsesto
the What
ifeverybodyislistening,
and
nobodyis
transmitting?
query.
Planet Labs is making use of information gathered from space to help with life on Earth. The group of scientists considered
the problem with most satellites to be their large and clunky form, prompting them to build inexpensive and compact satellites to be manufactured in bulk, called CubeSats.
How Brands Can Survive & Thrive Online - Digital EvolutionAndrea Vascellari
Andrea Vascellari's presentation about "digital evolution" and how "digital species" - in this case websites & web properties of brands and organizations - need to adapt to environmental changes (new technologies, etc...) or else they will be wiped off the face of the world wide web.
Head in the clouds: Engaging with the web for archaeologistsdavstott
This presentation was given on 22nd of september 2011 at the Aerial Archaeology Research Group (AARG) in Poznan, Poland.
It explores how archaeologists could exploit citizen science collaborations to make better use of the ever proliferating quantity of aerial and satellite data.
Future Of Literacy Education from the Vantage of the Open Education MovementAhrash Bissell
Keynote by Ahrash Bissell (ccLearn) to the Digital Library Federation (DLF) Fall Forum in Providence, RI. Draws lessons and aspirations from the open education movement and applies them to the future of libraries and literacy education.
Artigo descreve o código computacional utilizado no filme interstellar para gerar o buraco negro Gargantua e como isso trouxe conclusões e ideias sobre os buracos negros em rotação.
Will The International Space Station de-orbit_.pdfMausiquiOfficial
The International Space Station is revealing how old it very well may be. It’s more seasoned than 33% of the populace, north of over two billion individuals who have never known a period without people in circle.
Pieces and bits of it continue to turn out badly, most as of late the EVA spacesuits; Russia might possibly be going to bail; and it’s more Red Dwarf than the Enterprise with regards to space microbes.
You thought it was troublesome getting a cleaner to come to your condo in the city? According to one perspective, it’s exhausted, super-costly to run, and isn’t contributing a lot to space investigation any more, and is absorbing substantially a lot of room designers’ mind time.
Does that apply to any inheritance innovation you knew about? IT heritages don’t make cool recordings of the Earth from space or space travelers tumbling in microgravity, so they miss out vigorously to the International Space Station on the advertising front. They won’t be consuming 15% of a $22 billion spending plan by the same token
Check in to the Universe: NASA and Location Based Services Foursquare and Gow...Stephanie Schierholz
Presentation NASA's Social Media Manager Stephanie L. Schierholz gave about NASA's use of location based services and social media at the Social Media World Forum in New York on Wednesday, Nov. 2, 2011.
Searching for Intelligent Life on Other Planets is a Goal Worth PursuingNick White
Abstract
For centuries, humans have tilted back their heads and gazed upon the heavens in wonder. What’s out there and are we alone in this universe? This paper addresses the need for humans worldwide to continue our search for life on other planets, and argues that it is our natural instinct to discover new worlds, much like the early explorers of the 15th Century. The paper covers the leadership role of SETI, as well as the projected funds for such missions. Themes from fields like astrobiology, economics and motivation will be considered and analyzed from a neutral standpoint. This paper will entertain the notion that we may, in fact, be alone in this universe. Aside from the money, the interest and the people advocating for the extra-terrestrial search, this paper will also address the mathematical probability of life existing in our galaxy, using the famed Drake Equation, contemplating the “habitable zone,” and even looking at evidence of life already found. The paper concludes, explaining why the search for intelligent life on other planets and our universe is a worthwhile goal.
How AI, OpenAI, and ChatGPT impact business and software.Curtis Poe
ChatGPT and other large language models are changing how we work. This is a series of small lighting talks merged into one larger talk to explore some of the impacts.
The new class OOP system is being implemented in Perl now. It's been several years in development by a team of people with deep familiarity with object-oriented programming in other langauges, and also deep experience with Perl.
Let's see what that means and see some examples.
The current status of the Corinna OOP proposal for the Perl programming language.
After years of design and discussion, the Perl Steering Committee has accepted the Corinna RFC (in a scaled-back initial form) for inclusion in the Perl language.
This talk gives the history of the proposal and where we're going from here.
A rambling tour of surprising things in several OO languages. These and other features were considered while I was designing Corinna, the next-generation OO syntax being proposed for the Perl core.
Future Of Literacy Education from the Vantage of the Open Education MovementAhrash Bissell
Keynote by Ahrash Bissell (ccLearn) to the Digital Library Federation (DLF) Fall Forum in Providence, RI. Draws lessons and aspirations from the open education movement and applies them to the future of libraries and literacy education.
Artigo descreve o código computacional utilizado no filme interstellar para gerar o buraco negro Gargantua e como isso trouxe conclusões e ideias sobre os buracos negros em rotação.
Will The International Space Station de-orbit_.pdfMausiquiOfficial
The International Space Station is revealing how old it very well may be. It’s more seasoned than 33% of the populace, north of over two billion individuals who have never known a period without people in circle.
Pieces and bits of it continue to turn out badly, most as of late the EVA spacesuits; Russia might possibly be going to bail; and it’s more Red Dwarf than the Enterprise with regards to space microbes.
You thought it was troublesome getting a cleaner to come to your condo in the city? According to one perspective, it’s exhausted, super-costly to run, and isn’t contributing a lot to space investigation any more, and is absorbing substantially a lot of room designers’ mind time.
Does that apply to any inheritance innovation you knew about? IT heritages don’t make cool recordings of the Earth from space or space travelers tumbling in microgravity, so they miss out vigorously to the International Space Station on the advertising front. They won’t be consuming 15% of a $22 billion spending plan by the same token
Check in to the Universe: NASA and Location Based Services Foursquare and Gow...Stephanie Schierholz
Presentation NASA's Social Media Manager Stephanie L. Schierholz gave about NASA's use of location based services and social media at the Social Media World Forum in New York on Wednesday, Nov. 2, 2011.
Searching for Intelligent Life on Other Planets is a Goal Worth PursuingNick White
Abstract
For centuries, humans have tilted back their heads and gazed upon the heavens in wonder. What’s out there and are we alone in this universe? This paper addresses the need for humans worldwide to continue our search for life on other planets, and argues that it is our natural instinct to discover new worlds, much like the early explorers of the 15th Century. The paper covers the leadership role of SETI, as well as the projected funds for such missions. Themes from fields like astrobiology, economics and motivation will be considered and analyzed from a neutral standpoint. This paper will entertain the notion that we may, in fact, be alone in this universe. Aside from the money, the interest and the people advocating for the extra-terrestrial search, this paper will also address the mathematical probability of life existing in our galaxy, using the famed Drake Equation, contemplating the “habitable zone,” and even looking at evidence of life already found. The paper concludes, explaining why the search for intelligent life on other planets and our universe is a worthwhile goal.
How AI, OpenAI, and ChatGPT impact business and software.Curtis Poe
ChatGPT and other large language models are changing how we work. This is a series of small lighting talks merged into one larger talk to explore some of the impacts.
The new class OOP system is being implemented in Perl now. It's been several years in development by a team of people with deep familiarity with object-oriented programming in other langauges, and also deep experience with Perl.
Let's see what that means and see some examples.
The current status of the Corinna OOP proposal for the Perl programming language.
After years of design and discussion, the Perl Steering Committee has accepted the Corinna RFC (in a scaled-back initial form) for inclusion in the Perl language.
This talk gives the history of the proposal and where we're going from here.
A rambling tour of surprising things in several OO languages. These and other features were considered while I was designing Corinna, the next-generation OO syntax being proposed for the Perl core.
We're often faced with the "rewrite vs. refactor" debate for legacy code bases. Here we present both business and technical considerations involved in the decision.
Many people seem intimidated by Perl 6 because it's so complicated. However, a car can seem complicated if it's explained by a race car enthusiast, but most of us just get in and drive. In reality, Perl 6 isn't that hard and helps to avoid one of the largest class of errors that many programs have: passing data between functions.
In the long run, I suspect that Perl 6, given that it runs on the JVM, might become increasingly popular with enterprise clients who want the speed of development of dynamic languages, the ease of deployment with the JVM, and the safety of many "static" languages.
A curious mixture of the Internet and Agile development has led to more and more companies eliminating middle management. Some have eliminated management altogether. This talk explores this trend, discusses how modern corporations resemble feudal societies and why they're less likely to innovate.
We then survey many "managerless" companies that have arisen today, but also cover many highly successful, large, managerless companies who have been with us for decades, including some whose products you probably have in your home.
In evaluating developers, I routinely come across very talented developers with a decade or more of experience with databases who nonetheless can't design even the simplest of schemas. This presentation is based on my popular blog post of the same name: http://blogs.perl.org/users/ovid/2013/07/how-to-fake-database-design.html
It's long been noticed that public companies tend to be less innovative. There's also a trend in many Agile companies to eschew management. Are private, Agile companies without managers the future?
This talk is more about half-truths than lies, but the concepts are important. There are several areas in which we think we have more confidence in our information than we actually do. This presentation covers both areas in which the evidence is against our beliefs and areas in which we simply need more information.
A/B Testing - What your mother didn't tell youCurtis Poe
Many people think A/B testing is merely showing customers two versions of something and choosing the one that customers respond to better.
It's much, much more complex than that.
Test::Class::Moose combines Test::Class, Moose and Test::Most to take test suites to the next level. It gives you unparalleled levels of control and information for you test suite.
This my keynote speech for YAPC::Europe, 2012. It went over very well, but it is effectively a rough draft of this concept and needs work. However, it was popular enough that people kept asking to see it, even in its incomplete form.
This article describes how to test Perl programs with the excellent "Test::Class" module. It brings xUnit style testing to Perl. I explain many advanced tips and techniques which even experienced users of "Test::Class" might not be aware of.
The formatting is handled by an experimental piece of software I'm writing which turns Perl's POD format into beautiful postscript files.
Inheritance Versus Roles - The In-Depth VersionCurtis Poe
This is the paper to accompany my slides explaining what's wrong with inheritance and how traits (roles) help to solve these issues: http://www.slideshare.net/Ovid/inheritance-versus-roles
This is an expanded version of my "Refactoring with Roles" talk. People don't ask me how to use roles. They're easy to use. They ask me why to use roles. That's pretty easy to, so long as you understand what's wrong with inheritance. This talk covers that.
A paper for this talk is at http://www.slideshare.net/Ovid/inheritance-versus-roles-1799996
Toxic effects of heavy metals : Lead and Arsenicsanjana502982
Heavy metals are naturally occuring metallic chemical elements that have relatively high density, and are toxic at even low concentrations. All toxic metals are termed as heavy metals irrespective of their atomic mass and density, eg. arsenic, lead, mercury, cadmium, thallium, chromium, etc.
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...Travis Hills MN
Travis Hills of Minnesota developed a method to convert waste into high-value dry fertilizer, significantly enriching soil quality. By providing farmers with a valuable resource derived from waste, Travis Hills helps enhance farm profitability while promoting environmental stewardship. Travis Hills' sustainable practices lead to cost savings and increased revenue for farmers by improving resource efficiency and reducing waste.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptxMAGOTI ERNEST
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
ANAMOLOUS SECONDARY GROWTH IN DICOT ROOTS.pptxRASHMI M G
Abnormal or anomalous secondary growth in plants. It defines secondary growth as an increase in plant girth due to vascular cambium or cork cambium. Anomalous secondary growth does not follow the normal pattern of a single vascular cambium producing xylem internally and phloem externally.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
DERIVATION OF MODIFIED BERNOULLI EQUATION WITH VISCOUS EFFECTS AND TERMINAL V...Wasswaderrick3
In this book, we use conservation of energy techniques on a fluid element to derive the Modified Bernoulli equation of flow with viscous or friction effects. We derive the general equation of flow/ velocity and then from this we derive the Pouiselle flow equation, the transition flow equation and the turbulent flow equation. In the situations where there are no viscous effects , the equation reduces to the Bernoulli equation. From experimental results, we are able to include other terms in the Bernoulli equation. We also look at cases where pressure gradients exist. We use the Modified Bernoulli equation to derive equations of flow rate for pipes of different cross sectional areas connected together. We also extend our techniques of energy conservation to a sphere falling in a viscous medium under the effect of gravity. We demonstrate Stokes equation of terminal velocity and turbulent flow equation. We look at a way of calculating the time taken for a body to fall in a viscous medium. We also look at the general equation of terminal velocity.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Nutraceutical market, scope and growth: Herbal drug technology
life-off-earth.pptx
1. SETL
The Search for Extraterrestrial Life
(in our solar system)
By CactiStaccingCrane - Own work, CC BY-SA 4.0,
https://commons.wikimedia.org/w/index.php?curid=117012949
an axe AG orus: sun hot rock, moon cold rock. The Greeks were so fascinated by this idea they sentenced him to death for his statements, though he was only banished. LOTS of history skipped here.
Virtually all ‘universal’ probes for life target the ribosome, a molecule that makes encoded proteins. The ribosome is, almost by definition, not present in RNA organisms. Thus, searching for a shadow biosphere on Earth is hampered. If we aren’t sure if there’s a second biosphere on Earth, how can we detect it off Earth?
Where is the line between chemistry and biology?
Biopresentation is my term and is not found in the literature.
Biopresentation is my term and is not found in the literature. Assembly theory: leroy cronin. two most complex space molecules ethyl formate and n-propyl cyanide.[1] Querying the molecular web assembly website[2] reveals that each of them has an MA of 3, far lower than the threshold we have for life.
1. https://www.sciencedaily.com/releases/2009/04/090421080506.htm2. http://molecular-assembly.com/
Tryptophan may have been detected around a start 1,000LYA. It has an MA number of 11!
Potter Stewart (1915–1985), associate justice of the Supreme Court from 1958 to 1981, is frequently remembered for his famous nondefinition of obscenity: “I know it when I see it.”
There is no SETL Institute
Teleology: "the study of ends or purposes." A teleologist attempts to understand the purpose of something by looking at its results.
One way astronomers can estimate age of a star is by looking at it’s ”metal” content. Our sun is roughy 2% “metals”, meaning it’s a younger star.
Ganymede, largest moon in solar system (Jupiter) versus Mercury, the smallest planet.
At this point, we could have rogue planets whose moons could support life. This has been discussed via panspermia.
We could have more rogue planets than stars, but the jury’s out.
NASA's Hubble Space Telescope has found the best evidence yet for an underground saltwater ocean on Ganymede
Universe is almost 13.7 billion years old. Complex ulticellular life took almost a quarter the age of the universe to evolve. However, it’s possible that lack of metals in early universe pushes back the possibility of life. Maybe only 8 to 10 billion years ago could it have started. Cambrian Exlosion 5.38 GYA.
Simple multicellular may have started 3GYA and mitochondria appeared 1.5GYA
https://www.ed.ac.uk/unpublished/news/2012/intelligence-031212
octopuses are molluscs are cephaloppds
Multicellular gap might be solution to Fermi paradox
Type II Kardashev civilization
carbon-hydrogen or carbon-carbon bonds, although the definition of "organic" versus "inorganic" varies from author to author, and is a topic of debate.
Arthur C. Clark, 2010: Odyssey Two
The red is fresh, crystalline ice
Enceladus’ gravity is very weak, about 1% of Earth’s. Station keeping maneuvers to keep in orbit, due to Saturn’s high gravity.
False color image of Ligeia Mare, the second largest sea on Titan.
The disappearing hydrogen could be life using it instead of oxygen
January 14, 2005 by ESAHuygens probe during its successful descent to land on Titan. This is the colored view, following processing to add reflection spectra data, and gives a better indication of the actual color of the surface.
Funding has been lowered and not all parts are mature, so it’s not clear when/if it will launch.
92 x is like diving one kilometer down. Photo via Soviet Space Agency Venera 13 lander, March 1, 1982.
Venera 14 measured compressibility of lens cap. March 5, 1982.
No known abiotic production in terrestrial planets in significant quantities
Some estimates suggest Venus may have had water for three billion years
https://www.sci.news/space/planetaryscience/habitable-venus-07619.html
Thermus aquaticus was first extremophile discovered. 77°C, or 170°F water.
Ionizing radiation: particles or waves with energy to strip electrons from atoms. Killing cells, causing cancer, etc.
Often accepted that some extremophiles can survive on other planets
Some are archaea (first identified in 1977), a new domain of life (above kingdom)
Subsurface temperatures almost 300° colder?
There was very little water on Earth at this time because a Mars-sized object had collided with Earth, leading to the formation of the Moon (i.e., the Grand Impact Hypothesis).
Mars magnetosphere may have lasted as recently as 1 Gya
3 rovers.
Meteorite origin: passage through atmosphere detected. Age of rock. Chemical composition. Volcanic activity.
Magnetite crystals were not known to be produced by abiotic processes
Something is happening. We don’t know what it is. This does NOT mean life.
Temperatures on Mars can get up to 20°C (70°F) at the equator. Gale Crater is just south of that.
Percholorates added to desert soil from Chile produced those chemicals, but ratio of chlorine isotopes matched those of Earth. https://phys.org/news/2016-10-year-old-viking-life-mars.html
In other words, false positive for metabolism
Probably very little formate on Mars
Percholorates added to desert soil from Chile produced those chemicals, but ratio of chlorine isotopes matched those of Earth.
Not tested at 50°C mark, nor in the long-term dark storage
50°C was when metabolic activity of LR was significantly reduced
Dark storage was when metabolic activity of LR was eliminated
Percholorates added to desert soil from Chile produced those chemicals, but ratio of chlorine isotopes matched those of Earth.
Total Recall, 1990. Don’t bother with the 2012 remake with Colin Farrell (directed by Len Wisemen)
Cost is time + money
Discovering life may well shut down colonization plans. Panspermia, Lithospermia
Unknown means no conclusions
Common origin means we can’t extrapolote
All life has Amino acids with left-handed chirality
All sugars all have right-handed chirality
1011 to 1012 stars in our Galaxy-
If 1/billion chance of life, 100 to 1000 planets with life.
1/trillion? probably alone in our galaxy. Doesn’t account for lifespan of life.
1022 to 1024 stars in the Universe. 1/quintillion—10,000 to 1,000,000 planets with life. Probably the only life in our local group.
https://www.esa.int/Science_Exploration/Space_Science/Herschel/How_many_stars_are_there_in_the_Universe
Assuming separate origin
First discussed in 70s. Lots of work in last decade. They can produce amino acids and nucleic acid bases
follow-up paper in 2022 found even larger group of autocatalyzing “precursors”?
Once you have enough molecules that can interact with one another, the probability of a self-catalyzing cycle could approach 100%. That means if these are the precursors, life might be everywhere.
https://academic.oup.com/bioscience/article/63/11/877/2389920