This study analyzed clinical outcomes for patients in the UK undergoing laser treatment for diabetic retinopathy. For eyes treated for maculopathy:
- 9.2% had a deterioration in visual acuity equivalent to doubling the visual angle.
- Poorer outcomes were related to worse baseline visual acuity, diffuse (vs focal) maculopathy, and grid (vs focal) laser treatment.
- For eyes treated for proliferative retinopathy, the neovascularization fully regressed in 50.8% and visual acuity was less than 6/60 in 8.6%. Poorer outcomes were related to high-risk characteristics and coexisting maculopathy at baseline. Improvement was related to larger areas of
This document discusses diabetic macular edema (DME), its causes and prevalence, current treatments, and evidence for the use of ranibizumab (Lucentis) in the treatment of DME. Some key points:
- DME is the main cause of central vision loss in diabetic retinopathy and can affect 10-25% of diabetics depending on type of diabetes and insulin use.
- Current treatments include controlling blood sugar, blood pressure, lipids as well as laser photocoagulation and pharmacologic therapies like steroids and anti-VEGF drugs.
- Studies like RESOLVE, READ-2 and DRCR.net trials showed ranibizumab led to significant gains in
1) Clinical trials have shown that intraocular injections of anti-VEGF drugs are more effective than laser monotherapy for treating diabetic macular edema (DME), but nearly half of patients still require supplemental laser treatment after several months.
2) Subthreshold laser therapy, which causes no scarring or permanent retinal damage, has shown potential for reducing DME with better visual acuity outcomes compared to conventional laser therapy.
3) While anti-VEGF drugs provide excellent initial results for DME, laser therapy remains an important supplemental or primary treatment when edema persists or is located further from the fovea.
Has AMD management changed these days-DR AJAY DUANIAjayDudani1
This document discusses the evolution of treatments for neovascular age-related macular degeneration (nAMD) over time, from no treatment to anti-VEGF therapies like ranibizumab and aflibercept. It summarizes real-world evidence comparing ranibizumab and aflibercept, showing comparable visual and anatomical outcomes between the two. It also outlines ongoing development of new anti-VEGF treatments like brolucizumab that aim to further improve outcomes for nAMD patients by requiring fewer injections.
Avengers of DME -AJAY DUDANI MUMBAI RETINA CENTREAjayDudani1
- Non-responders and partial responders to anti-VEGF therapies are a major problem in treating diabetic macular edema (DME). Several clinical trials showed over 60% of patients failed to meet primary or secondary endpoints with anti-VEGF treatments over 2 years.
- The pathogenesis of DME is multifactorial, involving diverse cytokines including VEGF. Steroid treatments like dexamethasone intravitreal implant (Ozurdex) act on multiple inflammatory mediators, not just VEGF. Ozurdex provides both short and long-term efficacy in DME patients.
- Case reports demonstrate examples of DME patients who were unresponsive or rebounded with anti-VEGF therapies but showed fove
The document discusses key findings from several DRCR protocols:
1. Protocol B compared IV steroids and laser for DME and found steroids were not superior and had more adverse events than laser.
2. Protocol I found ranibizumab with prompt or deferred laser had superior vision outcomes compared to laser alone for DME. TA plus laser had similar results to ranibizumab.
3. Protocol S showed ranibizumab was non-inferior to PRP for PDR and had better vision outcomes and less DME and progression than PRP. However, long term stability is still unknown.
4. The PROTEUS study found ranibizumab plus PRP was more
The DRCR.net Protocol S study compared the safety and efficacy of panretinal photocoagulation (PRP) versus intravitreal injections of ranibizumab 0.5 mg for the treatment of proliferative diabetic retinopathy (PDR) without prior PRP and with vision of at least 20/30. Over two years, ranibizumab provided superior visual acuity gains, less visual field loss, and fewer vitrectomies compared to PRP. However, long-term outcomes beyond two years are still unknown, and PRP may provide more stable regression of PDR over 15 years without need for further treatment. So while ranibizumab was more effective at two years, more data is
Visual Outcome After Cataract Surgery In Patients With Retinitis Pigmentosa.Dr. Jagannath Boramani
This document summarizes a study on visual outcomes after cataract surgery in patients with retinitis pigmentosa (RP). The study reviewed 52 eyes of RP patients who underwent cataract surgery. It found that preoperative vision was poor, with 94% having vision worse than 6/60. After surgery, vision improved to ≥6/18 in 45.2% of patients. However, vision did not improve in 53.8% of patients. Better postoperative vision was associated with less advanced RP. The type of cataract, age of patient, or surgery type did not significantly affect outcomes. Final vision was better for phacoemulsification with IOL than for manual small-incision cataract
This document discusses diabetic macular edema (DME), its causes and prevalence, current treatments, and evidence for the use of ranibizumab (Lucentis) in the treatment of DME. Some key points:
- DME is the main cause of central vision loss in diabetic retinopathy and can affect 10-25% of diabetics depending on type of diabetes and insulin use.
- Current treatments include controlling blood sugar, blood pressure, lipids as well as laser photocoagulation and pharmacologic therapies like steroids and anti-VEGF drugs.
- Studies like RESOLVE, READ-2 and DRCR.net trials showed ranibizumab led to significant gains in
1) Clinical trials have shown that intraocular injections of anti-VEGF drugs are more effective than laser monotherapy for treating diabetic macular edema (DME), but nearly half of patients still require supplemental laser treatment after several months.
2) Subthreshold laser therapy, which causes no scarring or permanent retinal damage, has shown potential for reducing DME with better visual acuity outcomes compared to conventional laser therapy.
3) While anti-VEGF drugs provide excellent initial results for DME, laser therapy remains an important supplemental or primary treatment when edema persists or is located further from the fovea.
Has AMD management changed these days-DR AJAY DUANIAjayDudani1
This document discusses the evolution of treatments for neovascular age-related macular degeneration (nAMD) over time, from no treatment to anti-VEGF therapies like ranibizumab and aflibercept. It summarizes real-world evidence comparing ranibizumab and aflibercept, showing comparable visual and anatomical outcomes between the two. It also outlines ongoing development of new anti-VEGF treatments like brolucizumab that aim to further improve outcomes for nAMD patients by requiring fewer injections.
Avengers of DME -AJAY DUDANI MUMBAI RETINA CENTREAjayDudani1
- Non-responders and partial responders to anti-VEGF therapies are a major problem in treating diabetic macular edema (DME). Several clinical trials showed over 60% of patients failed to meet primary or secondary endpoints with anti-VEGF treatments over 2 years.
- The pathogenesis of DME is multifactorial, involving diverse cytokines including VEGF. Steroid treatments like dexamethasone intravitreal implant (Ozurdex) act on multiple inflammatory mediators, not just VEGF. Ozurdex provides both short and long-term efficacy in DME patients.
- Case reports demonstrate examples of DME patients who were unresponsive or rebounded with anti-VEGF therapies but showed fove
The document discusses key findings from several DRCR protocols:
1. Protocol B compared IV steroids and laser for DME and found steroids were not superior and had more adverse events than laser.
2. Protocol I found ranibizumab with prompt or deferred laser had superior vision outcomes compared to laser alone for DME. TA plus laser had similar results to ranibizumab.
3. Protocol S showed ranibizumab was non-inferior to PRP for PDR and had better vision outcomes and less DME and progression than PRP. However, long term stability is still unknown.
4. The PROTEUS study found ranibizumab plus PRP was more
The DRCR.net Protocol S study compared the safety and efficacy of panretinal photocoagulation (PRP) versus intravitreal injections of ranibizumab 0.5 mg for the treatment of proliferative diabetic retinopathy (PDR) without prior PRP and with vision of at least 20/30. Over two years, ranibizumab provided superior visual acuity gains, less visual field loss, and fewer vitrectomies compared to PRP. However, long-term outcomes beyond two years are still unknown, and PRP may provide more stable regression of PDR over 15 years without need for further treatment. So while ranibizumab was more effective at two years, more data is
Visual Outcome After Cataract Surgery In Patients With Retinitis Pigmentosa.Dr. Jagannath Boramani
This document summarizes a study on visual outcomes after cataract surgery in patients with retinitis pigmentosa (RP). The study reviewed 52 eyes of RP patients who underwent cataract surgery. It found that preoperative vision was poor, with 94% having vision worse than 6/60. After surgery, vision improved to ≥6/18 in 45.2% of patients. However, vision did not improve in 53.8% of patients. Better postoperative vision was associated with less advanced RP. The type of cataract, age of patient, or surgery type did not significantly affect outcomes. Final vision was better for phacoemulsification with IOL than for manual small-incision cataract
Clinical trials established in 2005 the efficacy of Ranibizumab (Lucentis, Genentech) for the treatment of neovascular age-related macular degeneration (wetAMD), the leading cause of legal blindness in the United States.This disease is affecting people over the age of 65 with a prevalence of 1.6 million and 200000 new cases per year in the USA .While awaiting approval for ranibizumab from the Food and Drug Administration, ophthalmologists began treating neovascular AMD with off-label use of bevacizumab (Avastin, Genentech), since the drug had a target specificity similar to that of ranibizumab and was available at low cost for about 50$ per monthly injection Vs 1950$ for Lucentis monthly injection.
Ranibizumab received the FDA approuval in 2006 to treat specifically the wetAMD,there was a huge debate about the cost effectiveness and the reimbursement of Lucentis in comparaison with Avastin for treating the eye disease.
This paper explores the dilemma from different angles.First,it make the emphasize on the need of realizing a head to head comparative study between the two drugs and the means to finance and to launch this study since many roadblocks have been identified.
Then, it explores and analyzes the Genentech reaction facing this problem and their strategy to emphasize on the higher risk of death with Avastin, as compared to Lucentis in one hand and in the other hand their strategy to extend the ophthalmologic indications for Lucentis, including diabetic macula edema (DME).
Finally it explores what value should be put on safety in health technology assessments HTAs by developing that we can’t just consider the dollar value of medicine alone but we need to consider the cost of adverse events caused by the treatment and the cost of living with these adverse events
1. The document discusses recent treatments for diabetic macular edema (DME), including laser therapy, anti-VEGF drugs like ranibizumab and bevacizumab, and steroids.
2. It also covers screening guidelines, lifestyle management to control diabetes and risks factors, and potential future therapies like implants for sustained drug delivery.
3. Surgery options like vitrectomy are discussed when DME is severe, along with postsurgical follow up schedules.
A Comparative Study of Age Related Macular Degeneration In Relation To SD-OCT...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Verteporfin photodynamic therapy (vPDT) improves vision and leads to polyp regression in polypoidal choroidal vasculopathy (PCV) in the short term. However, long-term benefits are limited due to recurrence of polyps and lesions. Studies show vPDT combined with ranibizumab injections results in greater polyp regression compared to ranibizumab alone, though vision gains are similar between combinations in 6 months. Larger and longer trials are needed to determine if initial vPDT with ranibizumab provides better long-term outcomes than deferred treatment.
This document discusses NT-501, a potential drug for treating geographic atrophy due to age-related macular degeneration. It begins by explaining that NT-501 is ciliary neurotrophic factor delivered to the retina via encapsulated cell technology implants. Studies found that NT-501 resulted in retinal thickness increases and visual acuity stabilization in patients. The conclusion is that NT-501 delivered by encapsulated cells appears to slow vision loss in geographic atrophy, especially for patients with better baseline vision.
This study examined the 1-year results of treating myopic choroidal neovascularization (CNV) with intravitreal bevacizumab injections. Twenty-nine patients received three initial monthly injections, with additional injections for persistent or recurrent CNV. At 1 year, visual acuity improved on average by 2.4 lines from baseline. Twenty-one patients (72.4%) gained over 2 lines of vision. Optical coherence tomography showed a reduction in central foveal thickness following treatment. The study demonstrates the long-term effectiveness of intravitreal bevacizumab for myopic CNV.
This document describes a case study of 13 patients with recalcitrant pseudophakic cystoid macular edema (CME) who were treated with intravitreal dexamethasone implants. Before the implants, patients had received topical steroids, NSAIDs, oral carbonic anhydrase inhibitors, and subtenon triamcinolone injections without resolution of CME. After dexamethasone implants, vision improved in all patients and OCT thickness decreased. One patient had recurrence and required a second implant. No patients experienced intraocular pressure spikes. The study concludes dexamethasone implants are a viable treatment for recalcitrant pseudophakic CME.
1. The document discusses the relationship between visual acuity and retinal thickness in diabetic macular edema (DME) as measured by optical coherence tomography (OCT). While visual acuity only modestly correlates with foveal thickness, DME affects the entire macula.
2. A study found that changes in OCT-measured central retinal thickness did not strongly correlate with changes in visual acuity in DME patients. Inflammation plays an important early role in the development of DME before fluid accumulation occurs.
3. Which anti-VEGF drug is best for DME treatment - ranibizumab, bevacizumab, or aflibercept - remains unclear based on real-world evidence,
Cyclosporine Ophthalmic Emulsion for Dry Eye Diseaseeyedoc34
Two randomized controlled trials compared the efficacy and safety of cyclosporine 0.05% and 0.10% ophthalmic emulsions to their vehicle in treating moderate to severe dry eye disease. Both concentrations of cyclosporine significantly improved corneal staining and blurred vision compared to vehicle after 4-6 months. Cyclosporine was well tolerated with few discontinuing due to adverse events. The studies found topical cyclosporine effective and safe for treating dry eye disease.
This study evaluated myopia as a risk factor for glaucoma by examining 200 eyes of 100 patients with myopia. The study found that 18% of eyes had established glaucoma, while 84% showed suspicious optic disc changes. A majority (46%) of eyes had intraocular pressures in the higher teens, and 10% had pressures over 21 mmHg. High myopes were more likely to have pressures over 21 mmHg (60% of high myopes). While most eyes had open anterior chamber angles, myopic females had a higher prevalence of glaucoma (25%) than myopic males (11.54%). The study confirms that myopia is a risk factor for glaucoma, with primary open-angle
Profile of secondary glaucoma cases in a tertiary eye care centre.iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Macular Degeneration - Update on clinical trial results and new treatmentspresmedaustralia
The CATT study found that ranibizumab (Lucentis) and bevacizumab (Avastin) produced similar visual acuity outcomes for wet AMD over 2 years. However, bevacizumab was less effective in reducing retinal swelling. There were also more serious systemic side effects with bevacizumab. While deaths, heart attacks and strokes were low with both drugs, CATT was not large enough to determine if there were meaningful differences in these rare but serious side effects. More research is still needed to determine longer term safety and efficacy.
This document summarizes a study that evaluated the use of intravitreal bevacizumab injections to treat central serous chorioretinopathy (CSCR). The study included 43 eyes of 32 patients with CSCR who received intravitreal injections of bevacizumab. Results showed that median visual acuity improved significantly from 0.25 at baseline to 0.7 at 6 months post-injection. Median central macular thickness also decreased significantly from 557 μm at baseline to 286 μm at 6 months. The study concluded that intravitreal bevacizumab injections were effective at improving vision and reducing neurosensory detachment in patients with CSCR.
Diabetic Retinopathy Detection System from Retinal Imagesijtsrd
Diabetes Mellitus is a disorder in metabolism of carbohydrates, and due to lack of the pancreatic hormone insulin sugars in the body are not oxidized to produce energy. Diabetic Retinopathy is a disorder of the retina resulting in impairment or vision loss. Improper blood sugar control is the main cause of diabetic retinopathy. That is the reason why early detection of retinopathy is crucial to prevent vision loss. Appearance of exudates, microaneurysms and hemorrhages are the early indications. In this study, we propose an algorithm for detection and classification of diabetic retinopathy. The proposed algorithm is based on the combination of various image processing techniques, which includes Contrast Limited Adaptive Histogram Equalization, Green channelization, Filtering and Thresholding. The objective measurements such as homogeneity, entropy, contrast, energy, dissimilarity, asm, correlation, mean and standard deviation are computed from processed images. These measurements are finally fed to Support Vector Machine and k Nearest Neighbors classifiers for classification and their results were analysed and compared. Aditi Devanand Lotliker | Amit Patil "Diabetic Retinopathy Detection System from Retinal Images" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38353.pdf Paper Url: https://www.ijtsrd.com/engineering/computer-engineering/38353/diabetic-retinopathy-detection-system-from-retinal-images/aditi-devanand-lotliker
Aim: To compare one Field Of View (1 - FOV) and two Field Of View (2 - FOV) photography for diabetic retinopathy detection by assessing and comparing disease level and outcome.
Methods: A retrospective audit of a random sample of 500 patients with known proliferative diabetic retinopathy (PDR or R3), and 500 non-proliferative diabetic retinopathy (NPDR or R2). Images were re-assessed according to the English program criteria for DR levels using 1-FOV.
This summary provides an overview of a systematic review and meta-analysis examining intraocular pressure (IOP) monitoring after intravitreal steroid administration:
- The review analyzed studies on IOP elevation following various intravitreal steroids (triamcinolone acetonide, fluocinolone acetonide, dexamethasone) administered via injection or sustained-release implants.
- A meta-analysis found that 32% of individuals developed ocular hypertension after intravitreal triamcinolone injection, while rates were higher for fluocinolone implants (66-79%) and lower for dexamethasone implants (11-15%).
- Risk factors for IOP elevation included pre
APPLY MACHINE LEARNING METHODS TO PREDICT FAILURE OF GLAUCOMA DRAINAGEIJDKP
This study used machine learning methods to predict the failure of glaucoma drainage devices (GDDs) based on patient data. Five classifiers (logistic regression, artificial neural network, random forest, decision tree, and support vector machine) were compared using 165 patient records. Logistic regression and random forest performed best on the small and large datasets respectively. Key predictors of failure identified were race (Black), use of beta-blockers, and glaucoma type (open-angle). Random forest and logistic regression showed potential to predict GDD outcomes based on minimal patient information and could help understand differences between device types.
Preventing Vision Loss in Diabetic RetinopathyRick Trevino
This document discusses diabetic retinopathy and methods for preventing vision loss. It describes the stages of diabetic retinopathy from background retinopathy to proliferative retinopathy. It emphasizes that glycemic control through strict management of blood sugar levels is the most effective treatment for preventing and reducing the risk of diabetic retinopathy. Later stages may require laser therapy or angiogenesis inhibitors. Maintaining optimal blood pressure and cholesterol levels also helps prevent vision loss from diabetic retinopathy.
This document discusses treatments for diabetic retinopathy, including laser treatment and anti-VEGF drugs. It provides details on panretinal laser photocoagulation to treat peripheral retinal ischemia and grid laser photocoagulation to treat macular edema. It also discusses various anti-VEGF drugs like bevacizumab, ranibizumab, and aflibercept that are administered via intravitreal injections to treat diabetic retinopathy. Complications of different treatments and diagnostic tools are also mentioned. Clinical trial results comparing anti-VEGF drugs and laser therapy are summarized.
Clinical trials established in 2005 the efficacy of Ranibizumab (Lucentis, Genentech) for the treatment of neovascular age-related macular degeneration (wetAMD), the leading cause of legal blindness in the United States.This disease is affecting people over the age of 65 with a prevalence of 1.6 million and 200000 new cases per year in the USA .While awaiting approval for ranibizumab from the Food and Drug Administration, ophthalmologists began treating neovascular AMD with off-label use of bevacizumab (Avastin, Genentech), since the drug had a target specificity similar to that of ranibizumab and was available at low cost for about 50$ per monthly injection Vs 1950$ for Lucentis monthly injection.
Ranibizumab received the FDA approuval in 2006 to treat specifically the wetAMD,there was a huge debate about the cost effectiveness and the reimbursement of Lucentis in comparaison with Avastin for treating the eye disease.
This paper explores the dilemma from different angles.First,it make the emphasize on the need of realizing a head to head comparative study between the two drugs and the means to finance and to launch this study since many roadblocks have been identified.
Then, it explores and analyzes the Genentech reaction facing this problem and their strategy to emphasize on the higher risk of death with Avastin, as compared to Lucentis in one hand and in the other hand their strategy to extend the ophthalmologic indications for Lucentis, including diabetic macula edema (DME).
Finally it explores what value should be put on safety in health technology assessments HTAs by developing that we can’t just consider the dollar value of medicine alone but we need to consider the cost of adverse events caused by the treatment and the cost of living with these adverse events
1. The document discusses recent treatments for diabetic macular edema (DME), including laser therapy, anti-VEGF drugs like ranibizumab and bevacizumab, and steroids.
2. It also covers screening guidelines, lifestyle management to control diabetes and risks factors, and potential future therapies like implants for sustained drug delivery.
3. Surgery options like vitrectomy are discussed when DME is severe, along with postsurgical follow up schedules.
A Comparative Study of Age Related Macular Degeneration In Relation To SD-OCT...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Verteporfin photodynamic therapy (vPDT) improves vision and leads to polyp regression in polypoidal choroidal vasculopathy (PCV) in the short term. However, long-term benefits are limited due to recurrence of polyps and lesions. Studies show vPDT combined with ranibizumab injections results in greater polyp regression compared to ranibizumab alone, though vision gains are similar between combinations in 6 months. Larger and longer trials are needed to determine if initial vPDT with ranibizumab provides better long-term outcomes than deferred treatment.
This document discusses NT-501, a potential drug for treating geographic atrophy due to age-related macular degeneration. It begins by explaining that NT-501 is ciliary neurotrophic factor delivered to the retina via encapsulated cell technology implants. Studies found that NT-501 resulted in retinal thickness increases and visual acuity stabilization in patients. The conclusion is that NT-501 delivered by encapsulated cells appears to slow vision loss in geographic atrophy, especially for patients with better baseline vision.
This study examined the 1-year results of treating myopic choroidal neovascularization (CNV) with intravitreal bevacizumab injections. Twenty-nine patients received three initial monthly injections, with additional injections for persistent or recurrent CNV. At 1 year, visual acuity improved on average by 2.4 lines from baseline. Twenty-one patients (72.4%) gained over 2 lines of vision. Optical coherence tomography showed a reduction in central foveal thickness following treatment. The study demonstrates the long-term effectiveness of intravitreal bevacizumab for myopic CNV.
This document describes a case study of 13 patients with recalcitrant pseudophakic cystoid macular edema (CME) who were treated with intravitreal dexamethasone implants. Before the implants, patients had received topical steroids, NSAIDs, oral carbonic anhydrase inhibitors, and subtenon triamcinolone injections without resolution of CME. After dexamethasone implants, vision improved in all patients and OCT thickness decreased. One patient had recurrence and required a second implant. No patients experienced intraocular pressure spikes. The study concludes dexamethasone implants are a viable treatment for recalcitrant pseudophakic CME.
1. The document discusses the relationship between visual acuity and retinal thickness in diabetic macular edema (DME) as measured by optical coherence tomography (OCT). While visual acuity only modestly correlates with foveal thickness, DME affects the entire macula.
2. A study found that changes in OCT-measured central retinal thickness did not strongly correlate with changes in visual acuity in DME patients. Inflammation plays an important early role in the development of DME before fluid accumulation occurs.
3. Which anti-VEGF drug is best for DME treatment - ranibizumab, bevacizumab, or aflibercept - remains unclear based on real-world evidence,
Cyclosporine Ophthalmic Emulsion for Dry Eye Diseaseeyedoc34
Two randomized controlled trials compared the efficacy and safety of cyclosporine 0.05% and 0.10% ophthalmic emulsions to their vehicle in treating moderate to severe dry eye disease. Both concentrations of cyclosporine significantly improved corneal staining and blurred vision compared to vehicle after 4-6 months. Cyclosporine was well tolerated with few discontinuing due to adverse events. The studies found topical cyclosporine effective and safe for treating dry eye disease.
This study evaluated myopia as a risk factor for glaucoma by examining 200 eyes of 100 patients with myopia. The study found that 18% of eyes had established glaucoma, while 84% showed suspicious optic disc changes. A majority (46%) of eyes had intraocular pressures in the higher teens, and 10% had pressures over 21 mmHg. High myopes were more likely to have pressures over 21 mmHg (60% of high myopes). While most eyes had open anterior chamber angles, myopic females had a higher prevalence of glaucoma (25%) than myopic males (11.54%). The study confirms that myopia is a risk factor for glaucoma, with primary open-angle
Profile of secondary glaucoma cases in a tertiary eye care centre.iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Macular Degeneration - Update on clinical trial results and new treatmentspresmedaustralia
The CATT study found that ranibizumab (Lucentis) and bevacizumab (Avastin) produced similar visual acuity outcomes for wet AMD over 2 years. However, bevacizumab was less effective in reducing retinal swelling. There were also more serious systemic side effects with bevacizumab. While deaths, heart attacks and strokes were low with both drugs, CATT was not large enough to determine if there were meaningful differences in these rare but serious side effects. More research is still needed to determine longer term safety and efficacy.
This document summarizes a study that evaluated the use of intravitreal bevacizumab injections to treat central serous chorioretinopathy (CSCR). The study included 43 eyes of 32 patients with CSCR who received intravitreal injections of bevacizumab. Results showed that median visual acuity improved significantly from 0.25 at baseline to 0.7 at 6 months post-injection. Median central macular thickness also decreased significantly from 557 μm at baseline to 286 μm at 6 months. The study concluded that intravitreal bevacizumab injections were effective at improving vision and reducing neurosensory detachment in patients with CSCR.
Diabetic Retinopathy Detection System from Retinal Imagesijtsrd
Diabetes Mellitus is a disorder in metabolism of carbohydrates, and due to lack of the pancreatic hormone insulin sugars in the body are not oxidized to produce energy. Diabetic Retinopathy is a disorder of the retina resulting in impairment or vision loss. Improper blood sugar control is the main cause of diabetic retinopathy. That is the reason why early detection of retinopathy is crucial to prevent vision loss. Appearance of exudates, microaneurysms and hemorrhages are the early indications. In this study, we propose an algorithm for detection and classification of diabetic retinopathy. The proposed algorithm is based on the combination of various image processing techniques, which includes Contrast Limited Adaptive Histogram Equalization, Green channelization, Filtering and Thresholding. The objective measurements such as homogeneity, entropy, contrast, energy, dissimilarity, asm, correlation, mean and standard deviation are computed from processed images. These measurements are finally fed to Support Vector Machine and k Nearest Neighbors classifiers for classification and their results were analysed and compared. Aditi Devanand Lotliker | Amit Patil "Diabetic Retinopathy Detection System from Retinal Images" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38353.pdf Paper Url: https://www.ijtsrd.com/engineering/computer-engineering/38353/diabetic-retinopathy-detection-system-from-retinal-images/aditi-devanand-lotliker
Aim: To compare one Field Of View (1 - FOV) and two Field Of View (2 - FOV) photography for diabetic retinopathy detection by assessing and comparing disease level and outcome.
Methods: A retrospective audit of a random sample of 500 patients with known proliferative diabetic retinopathy (PDR or R3), and 500 non-proliferative diabetic retinopathy (NPDR or R2). Images were re-assessed according to the English program criteria for DR levels using 1-FOV.
This summary provides an overview of a systematic review and meta-analysis examining intraocular pressure (IOP) monitoring after intravitreal steroid administration:
- The review analyzed studies on IOP elevation following various intravitreal steroids (triamcinolone acetonide, fluocinolone acetonide, dexamethasone) administered via injection or sustained-release implants.
- A meta-analysis found that 32% of individuals developed ocular hypertension after intravitreal triamcinolone injection, while rates were higher for fluocinolone implants (66-79%) and lower for dexamethasone implants (11-15%).
- Risk factors for IOP elevation included pre
APPLY MACHINE LEARNING METHODS TO PREDICT FAILURE OF GLAUCOMA DRAINAGEIJDKP
This study used machine learning methods to predict the failure of glaucoma drainage devices (GDDs) based on patient data. Five classifiers (logistic regression, artificial neural network, random forest, decision tree, and support vector machine) were compared using 165 patient records. Logistic regression and random forest performed best on the small and large datasets respectively. Key predictors of failure identified were race (Black), use of beta-blockers, and glaucoma type (open-angle). Random forest and logistic regression showed potential to predict GDD outcomes based on minimal patient information and could help understand differences between device types.
Preventing Vision Loss in Diabetic RetinopathyRick Trevino
This document discusses diabetic retinopathy and methods for preventing vision loss. It describes the stages of diabetic retinopathy from background retinopathy to proliferative retinopathy. It emphasizes that glycemic control through strict management of blood sugar levels is the most effective treatment for preventing and reducing the risk of diabetic retinopathy. Later stages may require laser therapy or angiogenesis inhibitors. Maintaining optimal blood pressure and cholesterol levels also helps prevent vision loss from diabetic retinopathy.
This document discusses treatments for diabetic retinopathy, including laser treatment and anti-VEGF drugs. It provides details on panretinal laser photocoagulation to treat peripheral retinal ischemia and grid laser photocoagulation to treat macular edema. It also discusses various anti-VEGF drugs like bevacizumab, ranibizumab, and aflibercept that are administered via intravitreal injections to treat diabetic retinopathy. Complications of different treatments and diagnostic tools are also mentioned. Clinical trial results comparing anti-VEGF drugs and laser therapy are summarized.
This document discusses diabetic macular edema (DME), including its prevalence, evaluation, treatment options, and intravitreal injection technique. DME is a leading cause of vision loss in diabetic retinopathy. Evaluation involves visual acuity testing, slit lamp examination, and imaging like OCT and FA. Treatment includes tight blood sugar and blood pressure control, as well as therapies like anti-VEGF agents, corticosteroids, and laser photocoagulation. Intravitreal injections are a common method to deliver these medications, with 30-gauge needles typically used for anti-VEGF drugs and 27-gauge for corticosteroids like triamcinolone.
Title:
Choosing amongst current modalities to manage Diabetic Retinopathy
At Medical Retina Clinic, Eye Department WAPDA Teaching Hospital Complex Lahore
Objective:
1. To review the current management options for DR
2. To share author’s four years follow up from Jan 2008 to Nov 2011 at Medical Retina Clinic, Eye Department WAPDA Teaching Hospital Complex Lahore.
3. Discussion on future Trends in management of DR.
Synopsis:
Diabetic retinopathy is the leading cause of new blindness in the world,
Argon LASER treatment has established itself as a gold standard in the management of DR. Intravitreal therapies in the form anti VEGF agents and steroids are also being widely used nationally and internationally. These therapies do not replace but complement each other.
Author will share his four years experience at Medical Retina clinic WAPDA hospital complex Lahore. 125 patients with DR were enrolled during this period. Treatment modalities used, included Argon Green Laser, Intravitreal Anti VEGF (Bevacizumab), Intravitreal Triamcinolone and subtenon Triamcinolone. Staging and severity of the disease as well as response to the offered therapy were the parameters used to tailor the treatment options.
Dr. Zia ul Mazhry
FRCS (Edin), FRCS (Glasgow), FCPS, CICOphth (UK)
Asstt Professor Central Park Medical College Lahore.
Consultant Eye Surgeon and Head of Eye Department
Wapda Teaching Hospital Complex
210 Feroz Pur Road Lahore.
Website: www.EyeAcuity.com
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VEGF is a growth factor that promotes abnormal blood vessel growth in the retina and causes vision loss. Anti-VEGF drugs like ranibizumab (Lucentis), bevacizumab (Avastin), and pegaptanib (Macugen) work by blocking VEGF and stopping this blood vessel growth. Ranibizumab was designed specifically for eye injections and has a short half-life, while bevacizumab was designed for cancer but is also used "off-label" in the eye. Clinical trials found that both drugs are effective in treating wet AMD, diabetic retinopathy, and other retinal diseases, but ranibizumab may have a slightly lower risk of rare side effects due to its shorter exposure in
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External download link: https://www.dropbox.com/s/i7qmd5ecj8c247x/glaucoma_overview.pdf?dl=0
Novel Development in treatment of Diabetic Macular Edema, by Dr. Fritz Allen, presented at VO, Lecture Series 11, Feb 20, 2011
COPE Course ID: 30657-PS
Clinical and dermographics profile of glaucoma patients in Hebron - Palestin...Riyad Banayot
ABSTRACT
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Assessment & management of patients with cataractHossein Mirzaie
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Incidence of Glaucoma & Diabetic Retinopathy in Patients with Diabetes Mellit...QUESTJOURNAL
Background: Vision is a means of communication of man with the external world. The impact of visual loss due to various ocular morbidities has profound implications for the person affected and the society as a whole. Diabetes has become one of the world’s most important public health problems & WHO indicate that 19% of world’s diabetic population lives in India. Diabetes related microvascular complications cause visual disability even in younger age group individuals. Aim: To estimate the magnitude of Glaucoma and diabetic retinopathy in diabetic patients in our institution. To create awareness about avoidable blindness in diabetic patients.To enlighten and thereby motivate the patient for further evaluation and follow up. Materials and methods: The study is a hospital- based , non- interventional, cross-sectional study. The ocular disorders are evaluated in 500 consecutive diabetic patients attending ophthalmology out patient department of Kanyakumari medical college hospital. Estimation of visual acuity, slit lamp examination, intraocular pressure, retinoscopy & fundus examination, visual field analysis , gonioscopy are done to detail the defective vision. Result analysis Data is analysed using SPSS. The common manifestations are cataract- 346 (69%), diabetic retinopathy- 94 patients (18.8%), glaucoma– 34 (6.8%). Patients with cataract are well managed by cataract extraction techniques. Prime importance is to create awareness and also diagnose the early changes of retinopathy and glaucoma.Treatment of glaucoma if instituted early will go a long way in preventing avoidable blindness Therefore periodic visual screening along with control of hyperglycemia and associated risk factors is needed to ensure good quality of vision.
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Diabetic macular edema (DME) is a major cause of vision loss in people with diabetes. DME affects up to 25% of people after 10 years of diabetes diagnosis and over 40% of people with type 1 diabetes in their lifetime. Current treatment options for DME include laser photocoagulation, anti-VEGF agents, and combined therapy of laser photocoagulation and anti-VEGF agents. Vitrectomy may improve outcomes for DME when there is also macular traction present. A new potential treatment, ocriplasmin, is an enzyme designed to cleave the vitreoretinal interface and has shown promise in resolving vitreomacular adhesion in early clinical trials without requiring
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Corneal blindness in a southern indian population [autosaved]meenank
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2. 152
Follow-up questionnaires were completed as close as
possible to 9 months following the initial laser treatment.
The follow-up questionnaire contained questions on
change in retinopathy features, visual acuity, and the
amount and type of treatment given.
All the data were returned to the Royal College of
Ophthalmologists and were double-entered, stored on a
computerised database, and analysed using a
commercially available statistical software package (SPSS
for windows 6.0).
Results
Maculopathy
Follow-up questionnaires were returned for 85% (464) of
the 546 patients initially recruited. Of these, 25 (5.4%)
patients were lost to follow-up and 13 (2.8%) had died.
Follow-up data were collected at a median of 277 days
(99-553 days, SD 59.4). There was no significant
difference in the age, gender, type of maculopathy or
visual acuity in the treated eye at baseline between those
with and without follow-up data.
Visual acuity
The best-recorded visual acuities at follow-up compared
with baseline are shown in Table 1. At follow-up 31.1%
(132) of eyes had a visual acuity of 6/6 or better, and
16.7% (71) had a visual acuity of 6/24 or worse. Where
the visual acuity was less than 6/9 at follow-up this was
said to be due to maculopathy in 74.1%, due to cataract in
9.9%, due to a combination of cataract and maculopathy
in 12.3%, due to vitreous haemorrhage in 1.2% and due
to macular traction in 1.2%. Two eyes had disciform age
related macular degeneration and two eyes were
amblyopic. Where the visual acuity in the treated eye
was less than 6/60 at follow-up (n = 14) this was said to
be due to cataract in 7.1%, vitreous haemorrhage in 7.1%,
disciform age-related macular degeneration in 7.1%, and
maculopathy in 78.6%. At follow-up there was no change
(± 1 Snellen line) in the best-recorded visual acuity in
79.6%, with a deterioration of more than 1 line in 10.1%
and an improvement of more than 1 line in 10.3%. In
order for a comparison to be made with other literature,
the Snellen visual acuities were converted to their
10gMAR equivalent; 9.2% of treated eyes lost 0.3 log units
or more of visual acuity (equivalent to a loss of 3 lines or
more on the ETDRS 10gMAR chart, or a doubling of the
visual angle8).
Table 2 shows the visual acuity at follow-up based
upon the type of maculopathy at baseline. For those with
exudative maculopathy prior to treatment, by the time of
follow-up there had been no change (± 1 Snellen line) in
83.2%, and an improvement of more than 1 line in 7.6%.
There had been a deterioration of 0.3 log units or more in
8.5%. For those with oedematous maculopathy, at follow
up there had been no change (± 1 Snellen line) in 71.2%,
and an improvement of more than 1 line in 14.3%. There
had been a deterioration of 0.3 log units or more in 15.4%.
For those with diffuse oedematous maculopathy prior to
treatment (a subgroup of those with oedematous
maculopathy), the visual acuity at follow-up was 6/9 or
better in 13.2% (5) and 6/24 or worse in 52.6% (20). At
follow-up, there had been no change in vision (± 1
Snellen line) in 71.8%, and an improvement of more than
1 line in 15.1%. There had been a deterioration of 0.3 log
units or more in 28.9%.
Stepwise multiple linear regression analysis was
performed to determine prognostic factors for visual
outcome. Factors included in the anlaysis were: visual
Table 1. Best-recorded visual acuity at follow-up compared with baseline for eyes undergoing photocoagulation treatment for maculopathy (row
percentages)
Visual acuity
Visual acuity at follow-up
at baseline 6/5 6/6 6/9 6/12 6/18 6/24 6/36 6/60 <6/60 Ana
6/5 n 26 14 4 0 0 1 0 0 0 45
% 57.8% 3.1% 8.9% 1.2% 10.6%
6/6 n 11 46 30 6 2 2 1 0 0 98
% 11.2% 46.9% 30.6% 6.1% 2.0% 2.0% 1.0% 23.1%
6/9 n 7 17 55 17 3 2 2 1 1 105
% 6.7% 16.2% 52.4% 16.2% 2.9% 1.9% 1.9% 1.0% 1.0% 24.8%
6/12 n 0 7 15 23 11 0 3 2 1 62
% 11.3% 24.2% 37.1% 17.7% 4.8% 3.2% 1.6% 14.6%
6/18 n 0 1 15 8 14 8 1 2 1 50
% 2.0% 30% 16% 28% 16% 2.0% 4.0% 2.0% 11.8%
6/24 n 1 1 0 5 7 6 4 1 5 30
% 3.3% 3.3% 16.7% 23.3% 20.0% 13.3% 3.3% 16.7% 7.1%
6/36 n 0 1 1 2 1 5 2 5 3 20
% 5.0% 5.0% 10.0% 5.0% 25.0% 10.0% 25.0% 15.0% 4.7%
6/60 n 0 0 1 0 0 0 1 6 0 8
% 12.5% 12.5% 75.0% 1.9%
<6/60 n 0 0 0 0 1 0 1 1 3 6
% 16.7% 16.7% 16.7% 50% 1.4%
All n 45 87 121 61 39 24 15 18 14 424
% 10.6% 20.5% 28.5% 14.4% 9.2% 5.7% 3.5% 4.2% 3.3% 100%
Missing baseline visual acuity data in 2 cases.
'Column percentage.
3. Table 2. The visual acuity at follow-up based upon the type of maculopathy at baseline
Exudative maculopathy Oedematous maculopathy
Visual acuity at follow-up n
6/5 43
6/6 72
6/9 97
6/12 43
6/18 24
6/24 15
6/36 3
6/60 7
<6/60 7
Total 311
acuity prior to treatment, age and gender of the patient,
type and duration of diabetes, type of maculopathy
(focal!diffuse or exudative/oedematous), type of
treatment given (focal or grid), systematic screening to
detect the retinopathy, grade of ophthalmologist
performing the treatment and the waiting times for
treatment (from listing and from referral).
The visual acuity at follow-up was significantly related
to the visual acuity at baseline (slope = 0.68, P < 0.01).
Focal maculopathy was associated with better visual
acuity at follow-up than was diffuse maculopathy
(average logMAR difference = 0.14, P < 0.01) and focal
treatment was associated with a better visual acuity at
follow-up compared with grid treatment (average
10gMAR difference = 0.15, P < 0.01). Other factors were not
independently related to the visual acuity at follow-up.
The change in acuity from baseline to follow-up was
related to the visual acuity at baseline: those eyes with
worse visual acuity at baseline had less deterioration in
visual acuity by the time of follow-up (slope = -0.28,
P < 0.01). Diffuse maculopathy was associated with more
deterioration in visual acuity than focal maculopathy
(average 10gMAR difference in deterioration = 0.03,
P < 0.01), and grid treatment was associated with more
deterioration in visual acuity than focal treatment (average
10gMAR difference in deterioration = 0.22, P < 0.01). Other
factors were not independently related to the change in
visual acuity between baseline and follow-up.
Multiple logistic regression analysis showed that a
loss of 0.3 log units of visual acuity (doubling of the
visual angle) or more was associated with grid (vs focal)
treatment (odds ratio (OR) = 4.2, P < 0.01), and diffuse (vs
focal) maculopathy (OR = 4.8, P = 0.02), but not
independently related to other factors.
Change in retinopathy features
Table 3 shows the change in macular exudate or oedema
at the time of follow-up. These findings were based upon
clinical examination alone in 84%, aided by colour
photographs in 10.7%, and by fluorescein angiography in
5.3%. Logistic regression analysis found that a
morphological improvement in the maculopathy was
more common with better visual acuity at baseline
(p < 0.01). Although a morphological improvement was
more common in eyes with exudative (vs oedematous)
OJ
,0 n %
13.8% 2 2.0%
23.2% 13 12.7%
31.2% 20 19.6%
13.8% 16 15.7%
7.7% 14 13.7%
4.8% 9 8.9%
1% 11 10.8%
2.3% 10 9.8%
2.3% 7 6.9%
100% 102 100%
maculopathy (p = 0.02) and in eyes undergoing focal (vs
grid) treatment (p = 0.02), this was not significant when
allowing for the visual acuity at baseline.
Progression to proliferative retinopathy
Overall for the eyes with maculopathy at baseline, 7.1%
(30) had developed proliferative retinopathy by the time
of follow-up. Of eyes with focal maculopathy at baseline
6.3% (23) developed proliferative retinopathy by the time
of follow-up, compared with 13.5% (5) of eyes with
diffuse oedematous maculopathy at baseline (Fisher's
exact test, p = 0.09).
Treatment given
Focal treatment alone had been given to 76.3% (325) of
patients, grid treatment alone to 14.8% (63) and a
combination of focal and grid treatment to 8.9% (38). At
the time of follow-up, the eye had been given only one
treatment session in 278 (65.2%), there had been two
Table 3. The change in maculopathy features at follow-up
n %
Change in macular exudate"
Improved 232 77.3%
Not changed 28 9.3%
Deteriorated 35 11.7%
Not known 5 1.7%
--
Total 300 100%
Change in macular oedemab
Improved 62 64.6%
Not changed 22 22.9%
Deteriorated 7 7.3%
Not known 5 5.2%
Total 96 100%
Change in diffuse macular oedemac
Improved 23 65.7%
Not changed 7 20.0%
Deteriorated 3 8.6%
Not known 2 5.7%--
Total 35 100%
apor eyes with predominantly exudative maculopathy at base
line. Missing data in 11 cases.
bpor eyes with predominantly oedematous maculopathy at
baseline. Missing data in 6 cases.
cThis represents a subgroup of those with macular oedema.
Missing data in 3 cases.
153
4. 154
treatment sessions in 109 (25.6%), three sessions in 31
(7.3%), and four or more sessions in 1.9% (8) (maximum 7
sessions).
For those eyes with exudative maculopathy at
baseline, focal treatment had been given in 88.1% (274),
grid treatment alone in 4.2% (13), and both grid and focal
treatment in 7.7% (24). Where the exudates had
improved at follow-up and no proliferative retinopathy
had developed (n = 209) the median number of burns
was 52 (range 4-1130, SD 155).
For eyes with focal or multifocal oedematous
maculopathy at baseline, focal treatment had been given
in 56.2% (36), grid treatment alone in 26.6% (17) and a
combination of grid and focal treatment in 17.2% (11).
Where the oedema had improved and no proliferative
retinopathy had developed, the median number of burns
was 118 (range 8-1226, SD 247).
For eyes with diffuse oedematous maculopathy at
baseline, focal treatment alone had been given in 28.9%
(11), grid treatment alone in 65.7% (25) and both grid and
focal treatment in 5.3% (2). For those eyes where the
diffuse oedema had improved and proliferative
retinopathy had not developed, the median number of
burns given was 125 (44-3218, SD 647).
The total number of laser burns was not related to the
type of maculopathy at baseline, but significantly more
burns were used for eyes treated with grid laser than
eyes with just focal or focal and grid treatment (p < 0.01,
Mann-Whitney U).
Retinopathy features in the other eye
Maculopathy was said to be present in the other eye in
63.6% (269) of patients, whilst 5.9% (25) had proliferative
retinopathy in the other eye. The other eye had received
photocoagulation treatment in 53.2% (225). In the better
eye, 72.8% of patients had a visual acuity of 6/9 or better,
and 0.7% had a visual acuity of less than 6/60.
Proliferative retinopathy
Follow-up questionnaires were returned for 82% (233) of
the 284 patients with proliferative retinopathy initially
recruited. Of these, 19 (8.2%) were lost to follow-up and 5
(2.1%) had died. Follow-up data were collected at a
median of 273 days (range 76-564 days, SD 56.6). There
was no significant difference in the age, gender, best
recorded visual acuity in the treated eye or the
retinopathy features at baseline between those with and
without follow-up data.
Visual acuity
The best-recorded visual acuities at follow-up compared
with baseline are shown in Table 4. At follow-up, 26.3%
of eyes had a visual acuity of 6/6 or better, and 21.9%
had a visual acuity of 6/24 or worse. Where the visual
acuity in the treated eye was less than 6/9 this was said
to be due to maculopathy in 45.3% (43), cataract in 17.9%
(17), vitreous haemorrhage in 16.8% (16), both cataract
and maculopathy in 9.5% (9), rubeotic glaucoma in 4.2%
(4), and both maculopathy and traction detachment in
5.3% (5). For those eyes with a best-recorded visual
acuity of less than 6/60 at follow-up (n = 18), this was
said to be due to maculopathy in 50% (9), vitreous
haemorrhage in 11.1% (2), rubeotic glaucoma in 22.2%
(4), and both maculopathy and traction detachment in
16.7% (3).
Stepwise multiple linear regression analysis showed
that poorer visual acuity at follow-up was related to
poorer visual acuity at baseline (slope = 0.8, P < 0.01),
female sex (average logMAR difference = 0.1, P < 0.01)
and the presence of maculopathy at baseline (average
Table 4. Best-recorded visual acuity at follow-up compared with baseline for eyes undergoing panretinal photocoagulation for proliferative
retinopathy (row percentages)
Visual acuity
Visual acuity at follow-up
at baseline 6/5 6/6 6/9 6/12 6/18 6/24 6/36 6/60 <6/60 Ana
6/5 n 8 13 8 0 0 0 0 0 0 29
% 27.6% 44.8% 27.6% 13.9%
6/6 n 6 11 16 4 2 0 0 41
% 14.6% 26.8% 39% 9.8% 4.9% 2.4% 2.4% 19.6%
6/9 n 2 10 28 8 0 2 2 1 54
% 3.7% 18.5% 51.9% 14.8% 3.7% 3.7% 1.9% 1.9% 25.8%
6/12 n 3 1 6 14 6 0 1 0 0 31
% 9.7% 3.2% 19.4% 45.2% 19.4% 3.2% 14.8%
6/18 n 0 1 1 8 2 3 2 4 1 22
% 4.5% 4.5% 36.4'Yo 9.1% 13.6% 9.1% 18.2% 4.5% 10.5%
6/24 n 0 0 0 2 1 5 0 0 2 10
% 20% 10% 50% 20% 4.8%
6/36 n 0 0 0 1 0 1 1 1 2 6
% 16.7% 16.7% 16.7% 16.7% 33.3% 2.9%
6/60 n 0 0 0 0 0 0 0 2 1 3
% 66.7% 33.3% 1.4%
<6/60 n 0 0 0 1 0 0 1 1 10 13
% 7.7% 7.7% 7.7% 76.9% 6.2%
All n 19 36 59 38 11 12 7 9 18 209
% 9.1% 17.2% 28.2% 18.2% 5.3% 5.7% 3.3% 4.3% 8.6% 100%
aColumn percentage.
5. Table 5. Change in the retinal new vessel features at follow-up for eyes with proliferative retinopathy prior to treatment
Change to new All cases* NVD alone NVE alone NVD and NVE
vessel features n % n % n % n %
Disappeared completely 78 38.4% 23 33.8% 46 50% 9 20.9%
Regressed but still present 80 39.4% 39 57.3% 22 23.9% 19 44.2%
Inactive fibrotic stalk 24 11.8% 4 5.9% 12 13.9% 8 18.6%
Not changed 10 4.9% 1 1.5% 7 7.6% 2 4.6%
Deteriorated 11 5.4% 1 1.5% 5 5.4% 5 11.9%
NVD, neovascularisation of the disc; NVE, neovascularisation elsewhere.
"Missing data in 6 cases.
logMAR difference = 0.1, P < 0.01), but not independently
related to the age of the patient, type or duration of
diabetes, grade of ophthalmologist performing the laser
treatment, systematic screening to detect the proliferative
retinopathy or the waiting time for treatment (from
listing and from the time of referral).
Change in the retinopathy features
Table 5 shows the change in the retinal new vessel
features by the time of follow-up. A new vitreous
haemorrhage since the first laser treatment had occurred
in 17.4% (36) of patients, whilst 4.9% (10) had developed
a new traction detachment and 1.5% (3) had undergone a
vitrectomy. Rubeosis was present at follow-up in 2.9%
(6), none of whom had had rubeosis at baseline. Where
rubeosis was present at baseline (n = 10), this had
resolved in 80% and follow-up data were not available in
2 cases. Overall, there was a poor morphological
outcome as defined by rubeosis, new traction
detachment, or requiring vitrectomy in 7.2% (15).
10.5% (22) of eyes had a deterioration in the new
vessel features, rubeosis, new traction detachment, or
had undergone a vitrectomy by the time of follow-up.
Multiple logistic regression analysis was performed to
assess factors related to poor morphological outcome.
Factors included in the analysis were age, gender, visual
acuity at baseline, the presence of maculopathy, vitreous
haemorrhage or high-risk characteristics at baseline,
systematic screening to detect the retinopathy, the
waiting time for the laser treatment (from listing and
from referral), the grade of ophthalmologist performing
the treatment, the number of laser bums given by the
time of follow-up, and the area of retina treated at the
first session. Poor morphological outcome (as defined by
rubeosis, new traction detachment or having had a
vitrectomy) was found to be related to the presence of
concurrent maculopathy at baseline (OR 7.1, P < 0.01),
female sex (OR 7.8, P = 0.02) and the presence of the
equivalent of high-risk characteristics at baseline (OR 9.2,
P = 0.04). Other factors were not found to be significantly
independently related to poor morphological outcome.
For those eyes with poor outcome the initial treatment
was intended to be given in one session in 4 cases. For
these eyes, the time booked for the next follow-up
appointment was a mean 9.7 weeks (6-13 weeks)
compared with a mean 6.1 weeks (1-12) for those eyes
without poor outcome (p = 0.02, Mann-Whitney U).
Treatment given
Table 6 shows the total number of laser bums given by
the time of follow-up. For all cases the median number of
laser bums given by the time of follow-up was 2113
(range 320-6771). There had been one treatment session
in 23.8% (49), two or three sessions in 52.5% (108), four or
five sessions in 21.4% (44) and six or more sessions in
2.5% (5), range 1-10.
For those eyes whose initial treatment was intended to
be given in one session, no further treatment was given
in 46.2% (42) but 19.8% (18) underwent one further
treatment session, 25.3% (23) underwent two further
sessions, and 8.8% (8) underwent three or more
treatment sessions.
For those eyes with neovascularisation of the disc
(NVD) at baseline where the new vessel features had
improved (regressed but still present, disappeared
completely or an inactive fibrotic stalk persisted) by the
time of follow-up, the median number of burns given
was 2300 (range 700-6771), over a median of three
Table 6. The number of laser burns given to eyes with proliferative retinopathy by the time of follow-up'
All cases Cases with 'high-risk characteristics
,b Cases with NVD which regressed fully
Total burns n % n % n %
<1000 19 9.4% 11 9.2% 7 15.9%
1000-1999 72 35.6% 41 34.2% 15 34.1%
2000-2999 61 30.2% 30 25.0% 12 27.3%
3000-3999 27 13.4% 20 16.7% 8 18.2%
4000-4999 12 5.9% 7 5.8% 1 2.3%
5000-5999 8 4.0% 8 6.7% 0
6000-6999 3 1.5% 3 2.5% 1 2.3%
Total 202 100% 120 100% 44 100%
"This may represent more than one treatment session. Missing data in 7 cases.
b
Eyes with NVD or NVE associated with vitreous haemorrhage, broadly equivalent to high-risk characteristics as defined in the
Diabetic Retinopathy Study.
155
6. 156
sessions (range 1-10). There was an improvement in the
disc new vessels with fewer than 3000 burns in 66.6% of
eyes. For those eyes with NVD prior to treatment where
the new vessel features improved after just one session
(n = 20), the median number of burns given was 1435
(range 736-2015).
For those eyes with NVD or neovascularisation
elsewhere (NVE) associated with vitreous haemorrhage
(broadly equivalent to the high-risk characteristics as
defined in the Diabetic Retinopathy Study (DRS», where
the new vessel features had improved by the time of
follow-up, the median number of burns given was 2285
(range 332--6771), given over a median of three sessions
(range 1-10). For those eyes with the equivalent of DRS
high-risk characteristics that improved in just one session
(n = 25), the median number of burns given was 1404
(range 332-2414).
For eyes with rubeosis at baseline, the median number
of burns to achieve regression was 3127 (range 800-5299),
n = 8.
Multiple logistic regression analysis was performed to
examine factors related to the regression of new vessels.
Factors included in the analysis were: age, gender, type
or duration of diabetes, visual acuity at baseline,
systematic screening for the retinopathy, the waiting
time for the laser treatment (from listing and from
referral), the presence of the equivalent of high-risk
characteristics at baseline and the total number of burns
given by the time of follow-up. The total number of
burns given by the time of follow-up was significantly
lower (p < 0.01) for the group in which the retinal vessels
had regressed fully (either disappeared completely or an
inactive fibrotic stalk persisted). The median number of
burns given for those in which the new vessels had
regressed was 1840 (330--6128) (over a median two
sessions) compared with a median 2470 (320--6771) (over
a median three sessions) in the group where the new
vessels had not regressed. For those eyes whose initial
treatment was to be given in one session, the area of
retina treated at the first session was significantly greater
in the group in which the retinal vessels had regressed
fully than in the group in which retinal new vessels were
persisting at the time of follow-up (p < 0.01). The spot
size used for the initial treatment was greater in the
group in which the retinal vessels had regressed
(p = 0.01), but there was no significant difference in the
number of burns used at the first treatment session.
A significantly higher proportion of eyes with just
NVE at baseline achieved regression of the new vessels
compared with those eyes with NVD with or without
NVE (63.2% vs 38.8%, chi-square = 11.2, P < 0.01). There
was no significant difference in the total number of burns
given to eyes with NVE alone compared with eyes with
NVD to achieve regression, or in the area of retina treated
where regression occurred after just one treatment
session (Mann-Whitney U, p = 0.55 and p = 0.52,
respectively). Eyes with persistent new vessels were
significantly more likely to have had a new vitreous
haemorrhage by the time of follow-up than eyes in which
the new vessels had regressed (chi-square = 12.7,
P < 0.001).
Concurrent maculopathy
For those eyes with concurrent maculopathy at baseline,
this was said to have improved in 47.7% (41), not
changed in 34.9% (30) and to have deteriorated in 17.4%
(15). New maculopathy in the treated eye reducing the
vision below 6/9 had developed in 13.2% (27) of patients
at follow-up.
Retinopathy features in the other eye
Proliferative retinopathy was present in the other eye in
62.3% (127) whilst there was maculopathy alone in 17.6%
(36) and background retinopathy in 17.6% (36). No
diabetic retinopathy had been detected in 2.5% (5). The
other eye had received photocoagulation treatment in
83.3% (170).
In their better eye, 39.2% of patients had a visual
acuity of 6/6 or better, and 4.3% had a visual acuity of
less than 6/60.
Discussion
Follow-up questionnaires were returned for 85% of
patients with maculopathy and 82% of patients with
proliferative retinopathy, and the follow-up sample
appeared to be representative of the groups at baseline.
This compares favourably with the National Cataract
Survey, where paired records were available on 82% of
patients initially recruited.12 It is, however, of some
concern that 5.4% of patients with maculopathy and 8.2%
of patients with proliferative retinopathy were lost to
clinical follow-up.
Maculopathy
The Early Treatment Diabetic Retinopathy Study
(ETDRS) found that at 1 year follow-up, 5% of treated
eyes (n = 754) versus 8% of untreated eyes (n = 1490) had
lost more than 15 letters on the ETDRS chart (equivalent
to 0.3 log units or more, and representing a doubling of
the visual angle).B In this audit, 9.2% of treated eyes lost
0.3 log units or more of visual acuity, and it would
therefore appear that the results in terms of visual acuity
are considerably worse than expected from the ETDRS.
However, the ETDRS recruited patients without
clinically significant macular oedema (39% of the group
assigned to immediate treatment) and this group could
be expected to do better than eyes already affected by
oedema. In our audit fewer eyes (15-19%) did not have
clinically significant macular oedema.ll In addition, eyes
with other significant ocular pathology or visual acuity
worse than 20/200 were excluded from the ETDRS,B and
it may well be that other ocular factors such as cataract
contributed to the worse visual acuity results in our
national sample.
7. The finding that the follow-up visual acuity was
significantly related to the baseline visual acuity is not
surprising, and the finding that there is less deterioration
for those eyes with worse visual acuity at baseline is
almost certainly related to the fact that eyes with already
poor visual acuity are not able to deteriorate much
further on the scale used (recording only 'less than 6/60'
for the group with the worst visual acuity). The chance of
losing 0.3 log units or more of visual acuity was not
found to be related to visual acuity at baseline.
The visual prognosis was better in the group with
focal (vs diffuse) maculopathy, allowing for the visual
acuity at baseline and treatment given as confounding
variables. The visual prognosis was also better for the
group given focal (vs grid) treatment, even allowing for
the visual acuity at baseline and the type of maculopathy
as confounding variables. The percentage of eyes
suffering a drop in vision equivalent to a doubling of the
visual angle was 8.5% for eyes with exudative
maculopathy, 15.4% for eyes with oedematous
maculopathy and 28.9% for the subgroup of eyes with
diffuse oedematous maculopathy at baseline. There was
an improvement in macular exudate and oedema in
77.3% and 64.6% respectively. A morphological
improvement in macular exudate/oedema was found to
be significantly related to better visual acuity at baseline,
pOSSibly reflecting a stage of disease that is still treatable.
However, logistic regression analysis showed that an
improvement in macular exudate/oedema was not
independently related to the type of maculopathy or to
the type of treatment given, although the visual acuity at
follow-up was related to both these factors. The rates of
morphological improvement would appear to be lower
than in other studies, where improvement in macular
exudate and oedema has been reported in 88-100%?,13 In
this study the changes in the macular exudate or oedema
were mainly based upon clinical examination, and
should be treated with a degree of caution, particularly
as there may have been different examiners at baseline
and follow-up and the follow-up period is fairly short.
The visual acuity is likely to be a more sensitive measure
of outcome, since the ophthalmologist completing the
questionnaire had only limited response options to the
change in the maculopathy appearance (improvement,
no change, a deterioration, or not known).
Waiting times (from referral and from listing) were
not found to be related to the visual acuity at follow-up,
but it was noted in the initial results that patients with
better visual acuity at baseline waited longer to be seen in
the ophthalmology clinic, suggesting a prioritisation
based upon visual acuity,u Although multiple regression
analysis did not show an independent association
between the visual acuity at follow-up and the detection
of retinopathy by systematic screening, better visual
acuity at baseline was found to be related to the detection
of retinopathy by screening,u
In the ETDRS progression to high-risk retinopathy
occurred in 26.7% after 5 years for those eyes with
macular oedema and less severe retinopathy at baseline
that were not treated with early scatter treatment. Ten
per cent of eyes that did not receive scatter treatment
initially had undergone scatter treatment after 1 year
because of progression to early proliferative
retinopathy/severe non-proliferative retinopathy (57%)
or high-risk proliferative retinopathy (43%).14 The rates
of progression to proliferative retinopathy are
comparable in our group. In this study a higher
proportion of eyes with diffuse (as opposed to focal)
maculopathy developed proliferative retinopathy by the
time of follow-up, although this was not found to be
statistically significant (p = 0.09). The trend would
suggest that diffuse changes may be more likely to be
associated with ischaemia, which carries a greater risk of
progression to neovascularisation.
In an audit of this nature, without photographs or
detailed description of the morphology, it is not possible
to comment on the adequacy of treatment. The treatment
given in general is in accordance with expectations
compared with the ETDRS, with the majority of patients
with focal maculopathy being given focal treatment. It is
of note, however, that grid treatment was associated with
a worse visual prognosis, even allowing for visual acuity
at baseline and the type of maculopathy as confounding
variables.
Proliferative retinopathy
In the DRS at 8 month follow-up, 0.4% of eyes treated
with argon laser had developed severe visual loss (visual
acuity less than 5/200) compared with 1.8% at 1 year. For
selection into the DRS patients had to have a visual
acuity of more than 20/100 at baseline. In this study, for
those patients whose visual acuity at presentation was
6/24 or better, 2.4% (5) had visual acuity of less than
6/60 at follow-up. This is broadly comparable with the
results from the DRS.
Table 7 shows a comparison of the response of NVD
to treatment between this audit, a prospective study by
Doft and Blankenship15 of 50 patients with proliferative
retinopathy and the Diabetic Retinopathy Study.16 It can
be seen that the results from this audit compare
favourably with these other studies.
As expected, poor morphological outcome (defined as
rubeosis at follow-up, traction detachment or having had
a vitrectomy) was associated with a higher rate of 'high
risk characteristics' at baseline. Interestingly it was also
associated with the presence of concurrent maculopathy
at baseline. The latter may represent more severe disease,
and suggest a need for more vigilant follow-up and
treatment as for the conventional accepted 'high-risk
characteristics'. In our audit the wait for the next follow
up appointment for those patients with poor
morphological outcome (whose initial treatment was to
be given in one session) was significantly longer than for
those with better outcome. Whether the wait had
contributed to the poor outcome is conjectural, but a
mean wait for reassessment of 9.7 weeks is too long in the
case of proliferative retinopathy, where re-intervention
needs to be sooner if the response was not adequate after
the first treatment. Doft and Blankenship15 found that for
15/
8. 158
Table 7. A comparison of the response of NVD to panrelinal photocoagulation treatment between this audit and other studies
Doft and Blankenship DRS (1 year follow-
(6-month follow-up up of treated eyes
This audit (eyes with of eyes with with moderate/ DRS (1 year follow-
NVD alone at moderate/severe severe NVD at up of untreated
Change to NVD baseline) NVD at baseline) baseline) controls)
Full regression 39.7%
Partial regression 57.3%
Same/worse/ungradable 3%
eyes undergoing pametinal photocoagulation the
response of retinopathy risk factors after 3 weeks was a
good predictor of the response by 6 months. A more
rational time for reassessment would be at 3-4 weeks,
particularly for eyes with high-risk characteristics or
where one suspects that the first treatment might not
have been sufficient. No other factors relating to poor
outcome were ascertained, but the numbers of patients in
this group was small, and it is possible that smaller
associations were not detected.
The DRS recommended 800 burns of SOO fLm spot size
as a minimum for initial pametinal photocoagulation?
The area of retina ablated at the first treatment session
was estimated using the standard formula of 1Tr2
multiplied by the number of burns. A number of
different lenses would have been used in the treatments,
and there may be variable uptake of laser burns, but a
calculation of the maximum possible area of retina treated
was made by assuming that all cases had been treated
using the quadraspheric lens. The baseline data showed
that some eyes were given smaller areas of retinal
ablation than the minimum recommended by the DRS.17
For eyes whose initial treatment was intended to be
given in one session, and which were given smaller areas
of retinal ablation than the minimum recommended in
the DRS, there was an improvement in the new vessel
features and no further treatment was given in the
follow-up period in 26.3% (10). For both eyes with NVD
alone or eyes with NVD or NVE associated with vitreous
haemorrhage, which improved after just one treatment
session, the median area of retina ablated was 11S.1 mm2,
with 2S% of each group receiving less than the DRS
minimum (based upon a calculation assuming use of the
quadraspheric lens). It would therefore appear that some
eyes do respond to smaller areas of retinal ablation than
recommended in the DRS protocol, including some eyes
with 'high-risk characteristics'.
Those eyes in which the retinal new vessels had
regressed fully had been given significantly fewer burns
by the time of follow-up than those in which the vessels
perSisted. This will reflect the continuation of treatment
for those eyes with persisting neovascularisation, and
highlights the fact that some eyes respond better to
treatment than others. It is certainly well documented in
other studies that some eyes require more treatment than
the initial DRS protocol;18,19 the lack of adequate
response in some of the more heavily treated cases in our
49% 29.8% 10.2%
23% 24.5% 13.1%
28% 45.7% 76.8%
audit merely confirms the diversity of response to
treatment, and the need to make allowance for individual
variation.
One feature in support of giving adequate amounts of
treatment at the first session was the finding that where
the new vessels had regressed fully by the time of follow
up, and the initial treatment was given in one session,
these eyes received larger areas of retinal ablation at the
first treatment session than the group in which the new
vessels were persisting at the time of follow-up. For these
eyes the larger area of retinal ablation was found to be
related to the use of larger spot size rather than the
number of burns. While there may be limiting factors to
achieving better results, the fact that less treatment is
needed for full regression in presumably less severe
cases raises the hope that if earlier detection is pOSSible
then the rate of success can be increased.
A new vitreous haemorrhage developed in 17.4% (36)
of eyes after the first treatment, and the common
occurrence of this complication merits a warning to the
patient when obtaining informed consent in order to
minimise undue anxiety. Of the 18 eyes (7.7%) of the
proliferative group that had a visual acuity of 6/60 or
less at follow-up, SO% were due to maculopathy and the
other half had developed other complications of
proliferative retinopathy either singly or in combination
(i.e. from vitreous haemorrhage, traction detachment or
rubeotic glaucoma). In the DRS, for eyes treated with the
argon laser that did not have macular oedema at
baseline, 12% lost more than 2 lines of visual acuity at 9
month follow-up?O This compares with this audit where
at follow-up 13.2% of eyes had developed new
maculopathy reducing their visual acuity below 6/9.
Conclusions
Bearing in mind that audit can answer only a limited
number of questions, some tentative conclusions and
recommendations can be drawn:
1. For patients with maculopathy, poorer visual
prognosis was related to worse visual acuity at baseline,
the presence of diffuse maculopathy, and the use of grid
treatment which was associated with a worse visual
outcome even allowing for visual acuity at baseline and
the type of macul.opathy as confounding variables. These
results do not support advocating the use of grid
treatment to the exclusion of focal or multifocal
applications.
9. 2. Patients with diffuse macular oedema had a greater
chance of developing proliferative retinopathy and need
careful follow-up to detect proliferative change.
3. For patients with proliferative retinopathy poor
morphological outcome was related to the presence of
high-risk characteristics, female sex, concurrent
maculopathy at baseline and longer follow-up after the
initial treatment. The time to the next follow-up
appointment needs to be shorter than sometimes given,
and a suggested time is 3-4 weeks.
4. In view of the frequent occurrence of new vitreous
haemorrhage after the first treatment, patients should be
warned specifically about this possibility.
5. Our finding that for those eyes where the new
vessels had regressed fully the area of retina ablated at
the first session was significantly greater than for the
group where the new vessels had persisted, would
suggest that adequate treatment at the first session is to
be recommended.
6. There is considerable variation in the response to
treatment, and some eyes responded to lower or higher
amounts of treatment than recommended in the DRS and
ETDRS protocols. Therefore each case needs to be judged
on its merit, and close follow-up is advised in case more
treatment is required.
7. Although there was no apparent independent
association between outcome and the detection of
retinopathy by systematic screening, this study did not
explore this aspect in detail. Better visual acuity at
baseline for eyes with maculopathy was found to be
related to the detection of retinopathy by systematic
screening, and outcome was related to baseline severity
for both maculopathy and proliferative retinopathy,
which argues for earlier detection of retinopathy and
improved screening.
We would like to thank all the ophthalmologists who took part
in this audit, and made this study possible. We would also like
to thank Professor D. McLeod, Mr J.5. Schilling and Mr J. Talbot
for their input as members of the steering committee for this
audit, Professor A.R. Rosenthal and Mr A.T. Moore as chairmen
of the audit committee, and the audit secretary Mrs Janice
Samson for her efficient assistance. The Department of Health
provided funding for this project.
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