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molecular biology of neurodevelopmental disorders, with particular emphasis on fragile
Call for Poster                                                                                 X syndrome, the leading heritable form of mental retardation. Since joining the Davis
                                                                                                faculty, Dr. Hagerman has expanded his research efforts to include investigations of the         nd
Theme     : Update on management and treatment of MR, Autism, and
            other Neurodevelopmental Disorder
                                                                                                underlying biochemical and genetic causes of autism.
                                                                                                Louise Gane, M.Sc
                                                                                                                                                                                               2   International Seminar and
Guidelines for submission of abstracts:
  1. A b s t r a c t s m a y b e s u b m i t t e d o n l y v i a e m a i l :
                                                                                                                         She is Senior Genetic Associate at the M.I.N.D. Institute. In 1991,
                                                                                                                         she joined the team led by Dr. Hagerman at the Fragile X              Workshop on Fragile-X, Autism
       mrautism.undip@gmail.com                                                                                          Research and Treatment Center in Denver, Colorado as a
  2. All abstracts must be submitted and written in English, maximum 250
       words.
                                                                                                                         genetic counsellor. Under the directorship of Dr. Randi
                                                                                                                         Hagerman, Louise is now located at the UC Davis M.I.N.D.                      and Related Disorders
                                                                                                                         Institute working as a Genetic Counsellor and Assistant to the
  3. Poster size: 90 x 120 cm (portrait)                                                                                 Director. She is involved in counselling patients with Fragile X
  4. Abstracts must contain original material neither published nor                                                      syndrome and their family members. In her role Louise helps
       presented elsewhere and must be approved by all contributing                             families deal with and understand the diagnosis, assessing genetic risk, and explaining
       authors.                                                                                 reproductive options
  5. Please structure your abstract using the following headings:
       Introduction, Objectives, Methods, Results, Conclusion.                                  Committee
  6. Abstracts will be subject to blind peer reviewers.




                                                                                                                                                                                                                         Acc I D I
                                                                                                                                      Patron
  7. Deadline of abstract submission : July 7, 2010 and two weeks later,




                                                                                                                                                                                                                                ited
                                                                                                                       Rector of Diponegoro University
       authors will be notified of acceptance by email.                                                            Director of Dr Kariadi Hospital Semarang




                                                                                                                                                                                                                            red
  8. Authors with accepted abstracts are entitled to register as                                           Dean, Faculty of Medicine Diponegoro University (FMDU)
       participants.                                                                                            Vice Rector for Development and Cooperation
  9. Poster should be displayed by the participants in person one hour                                                        Vice Dean for Finance
       prior the registration and should be standby during the Poster                                         Advisor of Center for Biomedical Research (Cebior)
       Session.                                                                                                                        Chair
                                                                                                                      Prof. Sultana MH Faradz, MD, PhD
                                                                                                                                     Co-Chair
International Speakers                                                                                                  Fitri Hartanto, MD (Pediatrician)
Prof. Randi J. Hagerman, MD                                                                                                         Secretary
                           Professor Randi Hagerman is a Developmental and Behavioral                                     Neni Susilaningsih, MD, Msc
                           Pediatrician and the Medical Director of the M.I.N.D. Institute at                             Muflihatul Muniroh, MD, MSc
                           UC Davis. She is internationally recognized as both a clinician                                          Secretariat
                           and researcher in the fragile X field. Professor Hagerman                            Nani Maharani, MD, Msc, Ardina Aprilani, S.Sos
                           received her M.D. from Stanford University where she also                                                Treasurer
                           carried out her Pediatric residency. She completed a
                                                                                                    Ratna Damma Purnawati, MD, Msc, Annastasia Ediati, S.Psi, MSc, Psi
                           Fellowship in Learning and Disabilities and Ambulatory
                                                                                                                               Scientific Committee
                                                                                                 Asri Purwanti, MD (Pediatrician), Alifiani Hikmah Putranti, MD (Pediatrician),
Pediatrics at UC San Diego and, subsequently, spent the next 20 years from 1980 to 2000 at
the University of Colorado where she headed Developmental and Behavioral Pediatrics.               Dani Rahmawati, MD (Neurologist), Alifiati Fitrikasari, MD (Psychiatrist),
She co-founded the National Fragile X Foundation in 1984 in Colorado and developed a                     Hexanto, MD (Neurologist), Eko Adhi Pangarsa, MD (Internist),
                                                                                                                                                                                                                 th
world-renowned fragile X research and treatment center. In 2000, Professor Hagerman
moved to UC Davis to be the Medical Director of the M.I.N.D. Institute. Dr. Hagerman and
                                                                                                 Yetty Movieta Nency, MD (Pediatrician), Farmaditya EP Mundhofir, MD, Msc,
                                                                                                     Maria Belladona, MD, M. Mexitalia Setiawati, MD, PhD (Pediatrician),                             Semarang, 7 August 2010
her team discovered the Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) which is a                             Rudi Handoyo, MD (Medical rehabilitation)
neurological disorder that affects older carriers of fragile X.                                                               Talk show Committee
Prof. Paul J. Hagerman, MD, PhD                                                                    Fitri Hartanto, MD (Pediatrician), Niken Puruhita, MD, MSc (Nutritionist)                                 Diponegoro University
                           He received both his M.D. and Ph.D. degrees from Stanford                      Agustini Utari, MD, MSc (Pediatrician), Costrie Ganes, SPsi                                                  in collaboration with:
                           University School of Medicine in 1977. This was followed by a                                 Audiovisual & Documentation
                           three year Leukemia Society Fellowship at UCSD, where he                              Ahmad Zulfa Juniarto, MD, MSc (Andrologist)                                               Medical Investigation of
                           began his studies of nucleic acid structure. He joined the                                             Accomodation                                                        Neurodevelopmental Disorders
                           University of Colorado in 1980, where he remained prior to                                     Aris Catur, MD (Neurologist)
                           joining the UC Davis faculty. Hagerman is currently on the                                               Translator
                                                                                                                                                                                                          (MIND) Institute, UC Davis
                           scientific advisory board of the Muscular Dystrophy
                                                                                                                                 Widagdo, S.Ked
                           Association, and recently shifted toward the study of the
comprises also a talk show session, which will present some
Background                                                        cases of autism and ID patients.                                                  Program
         Fragile-X syndrome (FXS) is the most common form
of inherited intellectual disabilities (ID). The clinical signs   Purpose                                                                         Saturday, August 7, 2010
are intellectual disabilities, hyperactive, autism,                                                                             07.30 - 08.00 Registration
                                                                  To disseminate recent advances and treatments in the field
psychoneurologic disorders, and macroorchidism (testes                                                                          08.00 - 08.15 Opening Speech by :
                                                                  of Fragile X syndrome, Autism and related disorders from
enlargement) in male. The common affected is in males;                                                                                            1. Chairperson
                                                                  the expert scientist to the parents and people who are
however, carrier female could have a mild intellectual            interested in those field.                                                      2. Rector of Diponegoro University
disability such as learning difficulties, without other                                                                         08.15 – 08.30 Future and challenges of Autism Center in
symptoms. Some clinically normal males (Normal                                                                                                Indonesia
Transmitting Males) are known to carry and transmit the           Venue
                                                                                                                                                Prof. Susilo Wibowo, MD, PhD, Andrologist
fragile X mutation to their daughter. In advance age, carriers    Patra Convention Hotel
                                                                                                                                08.30 - 08.50   Fragile X syndrome in Indonesia
of FXS could develop Fragile-X-Associated Tremor Ataxia           Jl. Sisingamangaraja, Semarang
(FXTAS), a neurodegenerative disorder.
                                                                                                                                                Prof. Sultana MH Faradz, MD, PhD
         Autistic spectrum disorder (ASD) involves                Participants                                                  08.50 – 09.20   RNA toxicity and FXTAS in Fragile-X
developmental abnormalities in reciprocal social                                                                                                premutation carriers
                                                                  This workshop is suited for parents, students                                 Prof. Paul Hagerman, MD, PhD
interaction, communication, and repetitive behavior. Some         (undergraduates and postgraduates), medical scientists,
genetic disorders associated with autism for example:             clinicians, nutritionist, psychologist, and people who are    09.20 - 09.50   Clinical Aspect of Autism and Its
Down Syndrome (DS), FXS and microdeletion chromosomal             interested. The number of participants is limited to 300                      Management
disorders such as Angelman syndrome, Prader Willi                 people.                                                                       Melly Budhiman, MD, Child Psychiatrist
syndrome etc. The information gap between experts and                                                                           09.50 – 10.20   Autism and Fragile X syndrome: Advances
parents could be a serious problem for patient                    Date                                                                          in Targeted treatments
management. Recently many studies in this field have been                                                                                       Prof. Randi J. Hagerman, MD, PhD
developed to find the newest and effective treatment and           August, 7th 2010
management.                                                                                                                     10.20 – 10.35   Discussion
         Advances in understanding the neurobiology of FXS        Registration Fee                                              10.50 – 11.05   Minocycline study in Fragile X syndrome
have led to new targeted treatments. The most remarkable           UNDIP staff                   Free                                           and Autism
are the metabotropic glutamate receptor 5 (mGluR5)                 Non UNDIP staff                                                              Agustini Utari, MD, M.Sc, Pediatrician
antagonists. The mGluR5 antagonists have been studied in           Physician (Specialist)        Rp. 500.000,-                  11.05 – 11.45   Psychopharmacological intervention in
animal models of fragile X and have been shown to have a           General Practitioner          Rp. 250.000,-                                  Autism and Fragile X syndrome
beneficial effect on seizures, cognition, and behavior.            Public                        Rp. 250.000,-                                  Prof. Randi J. Hagerman, MD, PhD
Another recent advances in FXS treatment is Minocycline.           Discount 50% for autism parents, FMDU students and           11.45 – 12.10   Genetic Counseling in Fragile X syndrome
Studies in animal models suggest that minocycline is not           alumni of genetic counselling master program UNDIP.
                                                                                                                                                and Autism
only useful as an antibiotic but may also has potential as
neuroprotective agent. Those advancements in FXS
                                                                                  Information and registration                                  Louise Gane, M.Sc
                                                                        Wiwik / Dina (Center for Biomedical Research)           12.10 – 12.25   Discussion
treatment in patients will be discussed in this workshop.
                                                                         GSG 2nd Floor Jl. Dr. Sutomo 14 Semarang               12.25 - 13.10   Lunch and poster session
         Within the framework of long collaboration with the
                                                                         Tel: +62-24-8412311 Fax: +62-24-8454714
Medical Investigation of Neurodevelopmental Disorders                                                                           13.10 – 15.20   Talk show (patients, parents and
                                                                                    HP:+62-81-931980014
(MIND) Institute, UC Davis, USA; Faculty of Medicine                                                                                            experts)
                                                                               e-mail : molcytogen@yahoo.com,
Diponegoro University (FMDU) Semarang Indonesia will                                                                            15.20 - 15.40   Best posters announcement and
                                                                                 genetikaundip@indosat.net.id
organize a 2nd International workshop on Fragile X                                                                                              Closing ceremony
                                                                                   website : www.cebior.co.cc
Syndrome, Autism and Related Disorders. This workshop

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Leaflet International Seminar On Autism Final

  • 1. molecular biology of neurodevelopmental disorders, with particular emphasis on fragile Call for Poster X syndrome, the leading heritable form of mental retardation. Since joining the Davis faculty, Dr. Hagerman has expanded his research efforts to include investigations of the nd Theme : Update on management and treatment of MR, Autism, and other Neurodevelopmental Disorder underlying biochemical and genetic causes of autism. Louise Gane, M.Sc 2 International Seminar and Guidelines for submission of abstracts: 1. A b s t r a c t s m a y b e s u b m i t t e d o n l y v i a e m a i l : She is Senior Genetic Associate at the M.I.N.D. Institute. In 1991, she joined the team led by Dr. Hagerman at the Fragile X Workshop on Fragile-X, Autism mrautism.undip@gmail.com Research and Treatment Center in Denver, Colorado as a 2. All abstracts must be submitted and written in English, maximum 250 words. genetic counsellor. Under the directorship of Dr. Randi Hagerman, Louise is now located at the UC Davis M.I.N.D. and Related Disorders Institute working as a Genetic Counsellor and Assistant to the 3. Poster size: 90 x 120 cm (portrait) Director. She is involved in counselling patients with Fragile X 4. Abstracts must contain original material neither published nor syndrome and their family members. In her role Louise helps presented elsewhere and must be approved by all contributing families deal with and understand the diagnosis, assessing genetic risk, and explaining authors. reproductive options 5. Please structure your abstract using the following headings: Introduction, Objectives, Methods, Results, Conclusion. Committee 6. Abstracts will be subject to blind peer reviewers. Acc I D I Patron 7. Deadline of abstract submission : July 7, 2010 and two weeks later, ited Rector of Diponegoro University authors will be notified of acceptance by email. Director of Dr Kariadi Hospital Semarang red 8. Authors with accepted abstracts are entitled to register as Dean, Faculty of Medicine Diponegoro University (FMDU) participants. Vice Rector for Development and Cooperation 9. Poster should be displayed by the participants in person one hour Vice Dean for Finance prior the registration and should be standby during the Poster Advisor of Center for Biomedical Research (Cebior) Session. Chair Prof. Sultana MH Faradz, MD, PhD Co-Chair International Speakers Fitri Hartanto, MD (Pediatrician) Prof. Randi J. Hagerman, MD Secretary Professor Randi Hagerman is a Developmental and Behavioral Neni Susilaningsih, MD, Msc Pediatrician and the Medical Director of the M.I.N.D. Institute at Muflihatul Muniroh, MD, MSc UC Davis. She is internationally recognized as both a clinician Secretariat and researcher in the fragile X field. Professor Hagerman Nani Maharani, MD, Msc, Ardina Aprilani, S.Sos received her M.D. from Stanford University where she also Treasurer carried out her Pediatric residency. She completed a Ratna Damma Purnawati, MD, Msc, Annastasia Ediati, S.Psi, MSc, Psi Fellowship in Learning and Disabilities and Ambulatory Scientific Committee Asri Purwanti, MD (Pediatrician), Alifiani Hikmah Putranti, MD (Pediatrician), Pediatrics at UC San Diego and, subsequently, spent the next 20 years from 1980 to 2000 at the University of Colorado where she headed Developmental and Behavioral Pediatrics. Dani Rahmawati, MD (Neurologist), Alifiati Fitrikasari, MD (Psychiatrist), She co-founded the National Fragile X Foundation in 1984 in Colorado and developed a Hexanto, MD (Neurologist), Eko Adhi Pangarsa, MD (Internist), th world-renowned fragile X research and treatment center. In 2000, Professor Hagerman moved to UC Davis to be the Medical Director of the M.I.N.D. Institute. Dr. Hagerman and Yetty Movieta Nency, MD (Pediatrician), Farmaditya EP Mundhofir, MD, Msc, Maria Belladona, MD, M. Mexitalia Setiawati, MD, PhD (Pediatrician), Semarang, 7 August 2010 her team discovered the Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) which is a Rudi Handoyo, MD (Medical rehabilitation) neurological disorder that affects older carriers of fragile X. Talk show Committee Prof. Paul J. Hagerman, MD, PhD Fitri Hartanto, MD (Pediatrician), Niken Puruhita, MD, MSc (Nutritionist) Diponegoro University He received both his M.D. and Ph.D. degrees from Stanford Agustini Utari, MD, MSc (Pediatrician), Costrie Ganes, SPsi in collaboration with: University School of Medicine in 1977. This was followed by a Audiovisual & Documentation three year Leukemia Society Fellowship at UCSD, where he Ahmad Zulfa Juniarto, MD, MSc (Andrologist) Medical Investigation of began his studies of nucleic acid structure. He joined the Accomodation Neurodevelopmental Disorders University of Colorado in 1980, where he remained prior to Aris Catur, MD (Neurologist) joining the UC Davis faculty. Hagerman is currently on the Translator (MIND) Institute, UC Davis scientific advisory board of the Muscular Dystrophy Widagdo, S.Ked Association, and recently shifted toward the study of the
  • 2. comprises also a talk show session, which will present some Background cases of autism and ID patients. Program Fragile-X syndrome (FXS) is the most common form of inherited intellectual disabilities (ID). The clinical signs Purpose Saturday, August 7, 2010 are intellectual disabilities, hyperactive, autism, 07.30 - 08.00 Registration To disseminate recent advances and treatments in the field psychoneurologic disorders, and macroorchidism (testes 08.00 - 08.15 Opening Speech by : of Fragile X syndrome, Autism and related disorders from enlargement) in male. The common affected is in males; 1. Chairperson the expert scientist to the parents and people who are however, carrier female could have a mild intellectual interested in those field. 2. Rector of Diponegoro University disability such as learning difficulties, without other 08.15 – 08.30 Future and challenges of Autism Center in symptoms. Some clinically normal males (Normal Indonesia Transmitting Males) are known to carry and transmit the Venue Prof. Susilo Wibowo, MD, PhD, Andrologist fragile X mutation to their daughter. In advance age, carriers Patra Convention Hotel 08.30 - 08.50 Fragile X syndrome in Indonesia of FXS could develop Fragile-X-Associated Tremor Ataxia Jl. Sisingamangaraja, Semarang (FXTAS), a neurodegenerative disorder. Prof. Sultana MH Faradz, MD, PhD Autistic spectrum disorder (ASD) involves Participants 08.50 – 09.20 RNA toxicity and FXTAS in Fragile-X developmental abnormalities in reciprocal social premutation carriers This workshop is suited for parents, students Prof. Paul Hagerman, MD, PhD interaction, communication, and repetitive behavior. Some (undergraduates and postgraduates), medical scientists, genetic disorders associated with autism for example: clinicians, nutritionist, psychologist, and people who are 09.20 - 09.50 Clinical Aspect of Autism and Its Down Syndrome (DS), FXS and microdeletion chromosomal interested. The number of participants is limited to 300 Management disorders such as Angelman syndrome, Prader Willi people. Melly Budhiman, MD, Child Psychiatrist syndrome etc. The information gap between experts and 09.50 – 10.20 Autism and Fragile X syndrome: Advances parents could be a serious problem for patient Date in Targeted treatments management. Recently many studies in this field have been Prof. Randi J. Hagerman, MD, PhD developed to find the newest and effective treatment and August, 7th 2010 management. 10.20 – 10.35 Discussion Advances in understanding the neurobiology of FXS Registration Fee 10.50 – 11.05 Minocycline study in Fragile X syndrome have led to new targeted treatments. The most remarkable UNDIP staff Free and Autism are the metabotropic glutamate receptor 5 (mGluR5) Non UNDIP staff Agustini Utari, MD, M.Sc, Pediatrician antagonists. The mGluR5 antagonists have been studied in Physician (Specialist) Rp. 500.000,- 11.05 – 11.45 Psychopharmacological intervention in animal models of fragile X and have been shown to have a General Practitioner Rp. 250.000,- Autism and Fragile X syndrome beneficial effect on seizures, cognition, and behavior. Public Rp. 250.000,- Prof. Randi J. Hagerman, MD, PhD Another recent advances in FXS treatment is Minocycline. Discount 50% for autism parents, FMDU students and 11.45 – 12.10 Genetic Counseling in Fragile X syndrome Studies in animal models suggest that minocycline is not alumni of genetic counselling master program UNDIP. and Autism only useful as an antibiotic but may also has potential as neuroprotective agent. Those advancements in FXS Information and registration Louise Gane, M.Sc Wiwik / Dina (Center for Biomedical Research) 12.10 – 12.25 Discussion treatment in patients will be discussed in this workshop. GSG 2nd Floor Jl. Dr. Sutomo 14 Semarang 12.25 - 13.10 Lunch and poster session Within the framework of long collaboration with the Tel: +62-24-8412311 Fax: +62-24-8454714 Medical Investigation of Neurodevelopmental Disorders 13.10 – 15.20 Talk show (patients, parents and HP:+62-81-931980014 (MIND) Institute, UC Davis, USA; Faculty of Medicine experts) e-mail : molcytogen@yahoo.com, Diponegoro University (FMDU) Semarang Indonesia will 15.20 - 15.40 Best posters announcement and genetikaundip@indosat.net.id organize a 2nd International workshop on Fragile X Closing ceremony website : www.cebior.co.cc Syndrome, Autism and Related Disorders. This workshop