Glenda Arnall has lived with Multiple Sclerosis (MS) for over 40 years and maintains her independence using an electric buggy. Her husband Professor Rodney Scott researches the genetics of MS at Hunter Medical Research Institute (HMRI) alongside Jeannette Lechner-Scott. The couple are participating in the PrevANZ clinical trial to determine if vitamin D supplements can prevent or delay the onset of MS. Glenda has also held fundraising events to support MS research and hopes research will lead to a cure.
The document discusses push and pull factors of immigration. Push factors force people to leave their home country, such as war, poverty, or dictatorship. Pull factors attract people to other countries, like marriage to someone living abroad, seeking better jobs or pay, or reuniting with family members in another nation. Pictures provide examples of migrants traveling long distances on foot, asylum seekers, protests for immigrant rights, and humanitarian aid for immigrants.
This document summarizes a research paper that examines the implications of using the Human Development Index (HDI) as a criterion for economic development planning. The paper presents a simple economic model and makes two key findings: 1) Maximizing the HDI requires setting consumption at the minimum level, implying equitable outcomes even without explicit inequality aversion. 2) The weight on income in the HDI plays little role in optimal plans, with expenditures on education and health being emphasized instead.
A family from the Caribbean is depicted in a 1950 painting set in Trafalgar Square, London. Life in Britain was difficult after World War 2, as many men went to fight and did not return, affecting population levels and the economy. People migrate due to push factors like poverty, conflict or natural disasters in their home country, or pull factors like employment opportunities or rights in another location.
Charlie Bucket will facilitate a meeting with Grandpa Joe and other attendees including Violet, Augusta Gloop, Michelle TV, and Veruka. The meeting will have a good room setup with the front of the room as the focus. Tips are provided for problem managing such as staying calm, having a positive mindset, respecting others, finding shared goals, and compromising. A 5 step problem solving process is outlined including defining the problem, finding alternatives, evaluating solutions, selecting the best option, and implementing it.
A document showed images for 10 seconds to memorize, then asked the user to write down as many as they could remember. It then showed images of items like coffee, money, and stamps that were linked by Fair Trade, explaining that Fair Trade aims to help producers in developing countries get a better deal.
This month I had the opportunity and good fortune to attend the IxDA (Interaction Design Association) conference in Amsterdam.
I prepared these slides to share some of these inspiring moments with my colleagues and friends back in San Francisco.
Photo Credits: IxDA Flickr
Video Credits: IxDA Vimeo
The document discusses push and pull factors of immigration. Push factors force people to leave their home country, such as war, poverty, or dictatorship. Pull factors attract people to other countries, like marriage to someone living abroad, seeking better jobs or pay, or reuniting with family members in another nation. Pictures provide examples of migrants traveling long distances on foot, asylum seekers, protests for immigrant rights, and humanitarian aid for immigrants.
This document summarizes a research paper that examines the implications of using the Human Development Index (HDI) as a criterion for economic development planning. The paper presents a simple economic model and makes two key findings: 1) Maximizing the HDI requires setting consumption at the minimum level, implying equitable outcomes even without explicit inequality aversion. 2) The weight on income in the HDI plays little role in optimal plans, with expenditures on education and health being emphasized instead.
A family from the Caribbean is depicted in a 1950 painting set in Trafalgar Square, London. Life in Britain was difficult after World War 2, as many men went to fight and did not return, affecting population levels and the economy. People migrate due to push factors like poverty, conflict or natural disasters in their home country, or pull factors like employment opportunities or rights in another location.
Charlie Bucket will facilitate a meeting with Grandpa Joe and other attendees including Violet, Augusta Gloop, Michelle TV, and Veruka. The meeting will have a good room setup with the front of the room as the focus. Tips are provided for problem managing such as staying calm, having a positive mindset, respecting others, finding shared goals, and compromising. A 5 step problem solving process is outlined including defining the problem, finding alternatives, evaluating solutions, selecting the best option, and implementing it.
A document showed images for 10 seconds to memorize, then asked the user to write down as many as they could remember. It then showed images of items like coffee, money, and stamps that were linked by Fair Trade, explaining that Fair Trade aims to help producers in developing countries get a better deal.
This month I had the opportunity and good fortune to attend the IxDA (Interaction Design Association) conference in Amsterdam.
I prepared these slides to share some of these inspiring moments with my colleagues and friends back in San Francisco.
Photo Credits: IxDA Flickr
Video Credits: IxDA Vimeo
Crystal Fitzgibbon suffered an acute stroke at age 26 that paralyzed her right side and rendered her unable to speak. She was given the clot-busting drug Tenecteplase, which was being trialled against the standard drug Alteplase. Within 24 hours, Crystal regained movement and speech in what doctors called the "Lazarus effect." Studies showed Tenecteplase helped more patients achieve major neurological improvement within a day compared to Alteplase. The successful trial of Tenecteplase provides hope for more effective stroke treatment.
Takes Guts to be a Neuroendocrine PatientBill Claxton
perspectives on the importance of raising awareness about NETs as well as the challenges a patient faces, and how the World NET Awareness Day campaign may benefit patients
The document provides updates from various departments at the Kimmel Cancer Center. It announces new treatments for prostate cancer including high intensity focused ultrasound. It highlights advances in areas like radiation oncology, integrative medicine, and stem cell research. It recognizes support from donors and announces new rankings for cancer care.
This document provides information about an upcoming international seminar and workshop on fragile X syndrome, autism, and related neurodevelopmental disorders. It will feature talks from two keynote speakers: Professor Randi Hagerman, the medical director of the MIND Institute at UC Davis, who is an expert in fragile X syndrome research; and Louise Gane, a genetic counselor from the MIND Institute who assists patients with fragile X syndrome. The event is being organized by Diponegoro University in collaboration with the MIND Institute and will include poster presentations and discussions on the management and treatment of mental retardation, autism, and other neurodevelopmental disorders.
This document summarizes a conference held between Dana-Farber Cancer Institute and Maine Medical Center to improve coordination of cancer care for patients from Maine who receive treatment at Dana-Farber. About 50-60 patients from Maine receive stem cell transplants at Dana-Farber each year. The conference gave clinicians from both institutions a chance to discuss the patient transfer process and how to reduce obstacles. The goal was to better address the needs of patients who must travel long distances for specialized cancer treatment.
Assessing the appropriateness of CT scans among pediatric ortho patientsImage gently
The article discusses assessing the appropriate use of CT scans among pediatric orthopedic patients to minimize radiation exposure. It notes that while CT scans can be necessary, other imaging options should be considered whenever possible. The authors conducted a review of studies on radiation doses from various imaging technologies used for pediatric orthopedic injuries. Their findings suggest current practices need reexamination based on nationally accepted best practices to balance imaging needs with minimizing radiation exposure.
CAMH researchers, led by Dr. Romina Mizrahi, are conducting innovative research using brain imaging and a specialized dye to map brain activity related to cannabis use and schizophrenia. They are the world leaders in this area. The dye allows them to see in real time how cannabis affects the endocannabinoid system in the brain. This research could lead to new treatments that reduce the risk of schizophrenia for those who use cannabis. Tamara overcame drug and alcohol addiction through CAMH's Aboriginal services program, which combines clinical treatment with cultural practices. The program helped her address trauma from losing family members and stay sober.
The document discusses research using zebrafish as an animal model to study Charcot-Marie-Tooth disease type 2A (CMT2A), which is caused by mutations in the mitofusin 2 (MFN2) gene. Researchers in the UK created a zebrafish model of CMT2A by knocking out the MFN2 gene. They found that zebrafish with the mutation showed progressive motor dysfunction after 100-200 days. Testing revealed decreased retrograde transport of mitochondria in neurons. The zebrafish model provides a useful system for exploring potential CMT2A therapies. The Hereditary Neuropathy Foundation is funding further therapeutic testing using this model over the next year.
The document discusses several developments for treating inherited neuropathies:
1) The first gene therapy clinical trial to treat an inherited neuropathy, Giant Axonal Neuropathy, is approved. It will deliver a healthy copy of the GAN gene to spinal cord nerves using an AAV9 viral vector.
2) The Hereditary Neuropathy Foundation is creating a directory of expert healthcare providers for Charcot-Marie-Tooth and providing them resources to improve diagnosis and care.
3) An advisory board meeting was held to discuss the Foundation's research funding to date and future goals, including several projects aimed at developing treatments for CMT and related diseases.
Dr. Ruham Nasany, medical director of the neuro oncology program, joins the p...Ruham Nasany
Dr. Ruham Nasany, medical director of the neuro-oncology program, joins the pink champions support group to talk about "chemo brain”. Introduction: Dr. Ruham Nasany is a neuro-oncologist who joined Upstate University Hospital and Cancer Center in Syracuse, New York in 2020 as the medical director of the neuro-oncology and brain tumor multidisciplinary program and assistant professor in the department of neurology. She is dual board certified in neurology and neuro-oncology.
Dr. Jeremy Broadhead introduces himself as the new chiropractor at the Center for Chiropractic and Wellness. He discusses growing up in Nevada and California, earning a degree in exercise science, and then becoming a chiropractor after reading about how chiropractic can help the body heal itself. A new study finds that nitrates and nitrites used in food processing are linked to increasing rates of Alzheimer's, Parkinson's, and diabetes. The study suggests exposure to these chemicals may be accelerating the aging process and disease development. The article includes an Italian rice salad recipe.
The document advertises an upcoming Integrative Cancer Care meeting hosted by the Best Answer for Cancer Foundation. The two-session meeting on April 28th will feature experts sharing the latest integrative cancer treatments that save lives. Session 1 from 8am to 12pm will include presentations from Dr. Garry Gordon on Pulsed Electro-magnetic Frequency therapy and Dr. Mark Rosenberg on treating cancer as a chronic disease rather than with traditional chemotherapy. The meeting costs $50 per session or $100 for both sessions.
Leading Australian Rett Syndrome researcher, Professor Helen Leonard's presentation from the Respite Plus Beyond Respite Forum, 2014 held at Twin Waters Resort, Sunshine Coast Australia
This document presents a lexicon developed by an ACR committee to standardize the terminology used in ultrasound reports for thyroid nodules. It defines six categories used to describe sonographic features of thyroid nodules: composition, echogenicity, shape, size/dimensions, margins, and flow/Doppler. The goal is to provide evidence-based recommendations for managing thyroid nodules based on standardized terminology that can improve diagnosis and risk stratification.
Personalized Medicine: The Future is Almost HereHannes Smárason
The document discusses how genome sequencing is becoming integrated into medical care, enabling personalized medicine. It describes how genome sequencing costs have plummeted in the last decade, allowing for widespread application. Major medical centers are now installing DNA sequencers and adopting genome sequencing to define ideal treatments tailored to a patient's genes. The future of medicine is moving towards routinely sequencing every patient's genome to personalize prevention and treatment.
Since his graduation in 1990, Dr. Samuel M. Theagene has been part of the medical field, including his most recent work as medical director of Central Park Physical Medicine in New York. Outside of his own work as an M.D., Dr. Samuel Theagene supports the activities of St. Jude Children's Research Hospital, which combats pediatric illness.
The document discusses the Precision Medicine Initiative (PMI) and Cancer Moonshot program. PMI aims to tailor medical treatment to individual characteristics like genes and lifestyle by collecting health data from 1 million volunteers. Cancer Moonshot seeks to accelerate cancer research advances by 5 years through tumor mapping, new technologies, data sharing, and engaging patients. Challenges include genetics not explaining all disease, tumor heterogeneity, and defining success. Precision medicine could reduce ineffective treatments and costs while advancing scientific understanding of disease.
P53 protein can repair DNA damage before cell replication. Studies found higher rates of germline DNA repair mutations in men with metastatic prostate cancer, such as with the BRCA1, BRCA2, MHSH2, and HOXB13 genes. These mutations were independent of family history and age of diagnosis. A limitation is that the studies only focused on specific genes and not how multiple genes may interact to influence disease. The student notes that identifying DNA mutations could help various cancer types and that education is needed on tobacco and UV radiation risks.
“Environmental sanitation means the art and science of applying sanitary, biological and physical science principles and knowledge to improve and control the environment therein for the protection of the health and welfare of the public”.The overall importance of sanitation are to provide a healthy living environment for everyone, to protect the natural resources (such as surface water, groundwater, soil ), and to provide safety, security and dignity for people when they defecate or urinate .Sanitation refers to public health conditions such as drinking clean water, sewage treatment, etc. All the effective tools and actions that help in keeping the environment clean come under sanitation. Sanitation refers to public health conditions such as drinking clean water, sewage treatment. All the effective tools and actions that help in keeping the environment clean and promotes public health is the necessary in todays life.
BBB and BCF
control the entry of compounds into the brain and
regulate brain homeostasis.
restricts access to brain cells of blood–borne compounds and
facilitates nutrients essential for normal metabolism to reach brain cells
More Related Content
Similar to HMRI Searcher Newsletter Summer 2012-13
Crystal Fitzgibbon suffered an acute stroke at age 26 that paralyzed her right side and rendered her unable to speak. She was given the clot-busting drug Tenecteplase, which was being trialled against the standard drug Alteplase. Within 24 hours, Crystal regained movement and speech in what doctors called the "Lazarus effect." Studies showed Tenecteplase helped more patients achieve major neurological improvement within a day compared to Alteplase. The successful trial of Tenecteplase provides hope for more effective stroke treatment.
Takes Guts to be a Neuroendocrine PatientBill Claxton
perspectives on the importance of raising awareness about NETs as well as the challenges a patient faces, and how the World NET Awareness Day campaign may benefit patients
The document provides updates from various departments at the Kimmel Cancer Center. It announces new treatments for prostate cancer including high intensity focused ultrasound. It highlights advances in areas like radiation oncology, integrative medicine, and stem cell research. It recognizes support from donors and announces new rankings for cancer care.
This document provides information about an upcoming international seminar and workshop on fragile X syndrome, autism, and related neurodevelopmental disorders. It will feature talks from two keynote speakers: Professor Randi Hagerman, the medical director of the MIND Institute at UC Davis, who is an expert in fragile X syndrome research; and Louise Gane, a genetic counselor from the MIND Institute who assists patients with fragile X syndrome. The event is being organized by Diponegoro University in collaboration with the MIND Institute and will include poster presentations and discussions on the management and treatment of mental retardation, autism, and other neurodevelopmental disorders.
This document summarizes a conference held between Dana-Farber Cancer Institute and Maine Medical Center to improve coordination of cancer care for patients from Maine who receive treatment at Dana-Farber. About 50-60 patients from Maine receive stem cell transplants at Dana-Farber each year. The conference gave clinicians from both institutions a chance to discuss the patient transfer process and how to reduce obstacles. The goal was to better address the needs of patients who must travel long distances for specialized cancer treatment.
Assessing the appropriateness of CT scans among pediatric ortho patientsImage gently
The article discusses assessing the appropriate use of CT scans among pediatric orthopedic patients to minimize radiation exposure. It notes that while CT scans can be necessary, other imaging options should be considered whenever possible. The authors conducted a review of studies on radiation doses from various imaging technologies used for pediatric orthopedic injuries. Their findings suggest current practices need reexamination based on nationally accepted best practices to balance imaging needs with minimizing radiation exposure.
CAMH researchers, led by Dr. Romina Mizrahi, are conducting innovative research using brain imaging and a specialized dye to map brain activity related to cannabis use and schizophrenia. They are the world leaders in this area. The dye allows them to see in real time how cannabis affects the endocannabinoid system in the brain. This research could lead to new treatments that reduce the risk of schizophrenia for those who use cannabis. Tamara overcame drug and alcohol addiction through CAMH's Aboriginal services program, which combines clinical treatment with cultural practices. The program helped her address trauma from losing family members and stay sober.
The document discusses research using zebrafish as an animal model to study Charcot-Marie-Tooth disease type 2A (CMT2A), which is caused by mutations in the mitofusin 2 (MFN2) gene. Researchers in the UK created a zebrafish model of CMT2A by knocking out the MFN2 gene. They found that zebrafish with the mutation showed progressive motor dysfunction after 100-200 days. Testing revealed decreased retrograde transport of mitochondria in neurons. The zebrafish model provides a useful system for exploring potential CMT2A therapies. The Hereditary Neuropathy Foundation is funding further therapeutic testing using this model over the next year.
The document discusses several developments for treating inherited neuropathies:
1) The first gene therapy clinical trial to treat an inherited neuropathy, Giant Axonal Neuropathy, is approved. It will deliver a healthy copy of the GAN gene to spinal cord nerves using an AAV9 viral vector.
2) The Hereditary Neuropathy Foundation is creating a directory of expert healthcare providers for Charcot-Marie-Tooth and providing them resources to improve diagnosis and care.
3) An advisory board meeting was held to discuss the Foundation's research funding to date and future goals, including several projects aimed at developing treatments for CMT and related diseases.
Dr. Ruham Nasany, medical director of the neuro oncology program, joins the p...Ruham Nasany
Dr. Ruham Nasany, medical director of the neuro-oncology program, joins the pink champions support group to talk about "chemo brain”. Introduction: Dr. Ruham Nasany is a neuro-oncologist who joined Upstate University Hospital and Cancer Center in Syracuse, New York in 2020 as the medical director of the neuro-oncology and brain tumor multidisciplinary program and assistant professor in the department of neurology. She is dual board certified in neurology and neuro-oncology.
Dr. Jeremy Broadhead introduces himself as the new chiropractor at the Center for Chiropractic and Wellness. He discusses growing up in Nevada and California, earning a degree in exercise science, and then becoming a chiropractor after reading about how chiropractic can help the body heal itself. A new study finds that nitrates and nitrites used in food processing are linked to increasing rates of Alzheimer's, Parkinson's, and diabetes. The study suggests exposure to these chemicals may be accelerating the aging process and disease development. The article includes an Italian rice salad recipe.
The document advertises an upcoming Integrative Cancer Care meeting hosted by the Best Answer for Cancer Foundation. The two-session meeting on April 28th will feature experts sharing the latest integrative cancer treatments that save lives. Session 1 from 8am to 12pm will include presentations from Dr. Garry Gordon on Pulsed Electro-magnetic Frequency therapy and Dr. Mark Rosenberg on treating cancer as a chronic disease rather than with traditional chemotherapy. The meeting costs $50 per session or $100 for both sessions.
Leading Australian Rett Syndrome researcher, Professor Helen Leonard's presentation from the Respite Plus Beyond Respite Forum, 2014 held at Twin Waters Resort, Sunshine Coast Australia
This document presents a lexicon developed by an ACR committee to standardize the terminology used in ultrasound reports for thyroid nodules. It defines six categories used to describe sonographic features of thyroid nodules: composition, echogenicity, shape, size/dimensions, margins, and flow/Doppler. The goal is to provide evidence-based recommendations for managing thyroid nodules based on standardized terminology that can improve diagnosis and risk stratification.
Personalized Medicine: The Future is Almost HereHannes Smárason
The document discusses how genome sequencing is becoming integrated into medical care, enabling personalized medicine. It describes how genome sequencing costs have plummeted in the last decade, allowing for widespread application. Major medical centers are now installing DNA sequencers and adopting genome sequencing to define ideal treatments tailored to a patient's genes. The future of medicine is moving towards routinely sequencing every patient's genome to personalize prevention and treatment.
Since his graduation in 1990, Dr. Samuel M. Theagene has been part of the medical field, including his most recent work as medical director of Central Park Physical Medicine in New York. Outside of his own work as an M.D., Dr. Samuel Theagene supports the activities of St. Jude Children's Research Hospital, which combats pediatric illness.
The document discusses the Precision Medicine Initiative (PMI) and Cancer Moonshot program. PMI aims to tailor medical treatment to individual characteristics like genes and lifestyle by collecting health data from 1 million volunteers. Cancer Moonshot seeks to accelerate cancer research advances by 5 years through tumor mapping, new technologies, data sharing, and engaging patients. Challenges include genetics not explaining all disease, tumor heterogeneity, and defining success. Precision medicine could reduce ineffective treatments and costs while advancing scientific understanding of disease.
P53 protein can repair DNA damage before cell replication. Studies found higher rates of germline DNA repair mutations in men with metastatic prostate cancer, such as with the BRCA1, BRCA2, MHSH2, and HOXB13 genes. These mutations were independent of family history and age of diagnosis. A limitation is that the studies only focused on specific genes and not how multiple genes may interact to influence disease. The student notes that identifying DNA mutations could help various cancer types and that education is needed on tobacco and UV radiation risks.
Similar to HMRI Searcher Newsletter Summer 2012-13 (20)
“Environmental sanitation means the art and science of applying sanitary, biological and physical science principles and knowledge to improve and control the environment therein for the protection of the health and welfare of the public”.The overall importance of sanitation are to provide a healthy living environment for everyone, to protect the natural resources (such as surface water, groundwater, soil ), and to provide safety, security and dignity for people when they defecate or urinate .Sanitation refers to public health conditions such as drinking clean water, sewage treatment, etc. All the effective tools and actions that help in keeping the environment clean come under sanitation. Sanitation refers to public health conditions such as drinking clean water, sewage treatment. All the effective tools and actions that help in keeping the environment clean and promotes public health is the necessary in todays life.
BBB and BCF
control the entry of compounds into the brain and
regulate brain homeostasis.
restricts access to brain cells of blood–borne compounds and
facilitates nutrients essential for normal metabolism to reach brain cells
Congestive Heart failure is caused by low cardiac output and high sympathetic discharge. Diuretics reduce preload, ACE inhibitors lower afterload, beta blockers reduce sympathetic activity, and digitalis has inotropic effects. Newer medications target vasodilation and myosin activation to improve heart efficiency while lowering energy requirements. Combination therapy, following an assessment of cardiac function and volume status, is the most effective strategy to heart failure care.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Storyboard on Acne-Innovative Learning-M. pharm. (2nd sem.) CosmeticsMuskanShingari
Acne is a common skin condition that occurs when hair follicles become clogged with oil and dead skin cells. It typically manifests as pimples, blackheads, or whiteheads, often on the face, chest, shoulders, or back. Acne can range from mild to severe and may cause emotional distress and scarring in some cases.
**Causes:**
1. **Excess Oil Production:** Hormonal changes during adolescence or certain times in adulthood can increase sebum (oil) production, leading to clogged pores.
2. **Clogged Pores:** When dead skin cells and oil block hair follicles, bacteria (usually Propionibacterium acnes) can thrive, causing inflammation and acne lesions.
3. **Hormonal Factors:** Fluctuations in hormone levels, such as during puberty, menstrual cycles, pregnancy, or certain medical conditions, can contribute to acne.
4. **Genetics:** A family history of acne can increase the likelihood of developing the condition.
**Types of Acne:**
- **Whiteheads:** Closed plugged pores.
- **Blackheads:** Open plugged pores with a dark surface.
- **Papules:** Small red, tender bumps.
- **Pustules:** Pimples with pus at their tips.
- **Nodules:** Large, solid, painful lumps beneath the surface.
- **Cysts:** Painful, pus-filled lumps beneath the surface that can cause scarring.
**Treatment:**
Treatment depends on the severity and type of acne but may include:
- **Topical Treatments:** Such as benzoyl peroxide, salicylic acid, or retinoids to reduce bacteria and unclog pores.
- **Oral Medications:** Antibiotics or oral contraceptives for hormonal acne.
- **Procedures:** Such as chemical peels, extraction of comedones, or light therapy for more severe cases.
**Prevention and Management:**
- **Cleanse:** Regularly wash skin with a gentle cleanser.
- **Moisturize:** Use non-comedogenic moisturizers to keep skin hydrated without clogging pores.
- **Avoid Irritants:** Such as harsh cosmetics or excessive scrubbing.
- **Sun Protection:** Use sunscreen to prevent exacerbation of acne scars and inflammation.
Acne treatment can take time, and consistency in skincare routines and treatments is crucial. Consulting a dermatologist can help tailor a treatment plan that suits individual needs and reduces the risk of scarring or long-term skin damage.
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)GeorgeKieling1
Home
Organization
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
Selective alpha1 blockers are Prazosin, Terazosin, Doxazosin, Tamsulosin and Silodosin majorly used to treat BPH, also hypertension, PTSD, Raynaud's phenomenon, CHF
Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or at least to improve the clinical status of a patient.
One of the basic concepts of gene therapy is to transform viruses into genetic shuttles, which will deliver the gene of interest into the target cells.
Safe methods have been devised to do this, using several viral and non-viral vectors.
In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient's cells instead of using drugs or surgery.
The biggest hurdle faced by medical research in gene therapy is the availability of effective gene-carrying vectors that meet all of the following criteria:
Protection of transgene or genetic cargo from degradative action of systemic and endonucleases,
Delivery of genetic material to the target site, i.e., either cell cytoplasm or nucleus,
Low potential of triggering unwanted immune responses or genotoxicity,
Economical and feasible availability for patients .
Viruses are naturally evolved vehicles that efficiently transfer their genes into host cells.
Choice of viral vector is dependent on gene transfer efficiency, capacity to carry foreign genes, toxicity, stability, immune responses towards viral antigens and potential viral recombination.
There are a wide variety of vectors used to deliver DNA or oligo nucleotides into mammalian cells, either in vitro or in vivo.
The most common vector system based on retroviruses, adenoviruses, herpes simplex viruses, adeno associated viruses.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
Storyboard on Skin- Innovative Learning (M-pharm) 2nd sem. (Cosmetics)MuskanShingari
Skin is the largest organ of the human body, serving crucial functions that include protection, sensation, regulation, and synthesis. Structurally, it consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous layer).
1. **Epidermis**: The outermost layer primarily composed of epithelial cells called keratinocytes. It provides a protective barrier against environmental factors, pathogens, and UV radiation.
2. **Dermis**: Located beneath the epidermis, the dermis contains connective tissue, blood vessels, hair follicles, and sweat glands. It plays a vital role in supporting and nourishing the epidermis, regulating body temperature, and housing sensory receptors for touch, pressure, temperature, and pain.
3. **Hypodermis**: Also known as the subcutaneous layer, it consists of fat and connective tissue that anchors the skin to underlying structures like muscles and bones. It provides insulation, cushioning, and energy storage.
Skin performs essential functions such as regulating body temperature through sweat production and blood flow control, synthesizing vitamin D when exposed to sunlight, and serving as a sensory interface with the external environment.
Maintaining skin health is crucial for overall well-being, involving proper hygiene, hydration, protection from sun exposure, and avoiding harmful substances. Skin conditions and diseases range from minor irritations to chronic disorders, emphasizing the importance of regular care and medical attention when needed.
Storyboard on Skin- Innovative Learning (M-pharm) 2nd sem. (Cosmetics)
HMRI Searcher Newsletter Summer 2012-13
1. summer 2012
searcher
Solving the
MS mysteries
Trawlers, tugs, ships, silos –
everything has something to “say”,
declares Glenda Arnall as she drinks
in the eye-watering view from her
Newcastle Harbour penthouse.
Having lived in the stunning
home for four years – and lived with
Multiple Sclerosis (MS) for 40-plus
years – Glenda takes every day as a
blessing.
She zips around the balcony, and MS patient Glenda Arnall has lived with the disease for more than 40 years.
the Honeysuckle precinct for that BELOW: Researchers Rodney Scott and Jeannette Lechner-Scott.
matter, on an electric buggy as she
fiercely maintains her independence. clinical coalface. Her husband The pair are intrigued by
“I’ve been in a buggy for five Professor Rodney Scott, meanwhile, the complexity of a disease
years because it’s easier. I can walk works at the cutting edge of genetics that combines neurology and
with the aid of two sticks but I’m as co-leader of HMRI’s Information immunology.
impatient,” Glenda says. Based Medicine Program. “Studies have now identified 123
The penthouse suits her lifestyle genes predisposing to MS – Now
perfectly, and also inspired Glenda we need to find out how we can
to hold a fundraising evening called influence them,” Jeannette says.
“View for a Cause” in late November. Rodney adds: “All of us have a
“I have five granddaughters and risk but some cross a threshold and
I want them to visit all the time,” develop the disease.”
Glenda says. “The girls are also The HMRI team is now
one of the incentives for doing the participating in a world-first clinical
fundraiser – the money might be the trial, known as PrevANZ, which will
catalyst for finding a cure. determine if Vitamin D supplements
“They’re all perfectly healthy and Their research paths merge can prevent or delay the early
beautiful but you just don’t know. I because genetic and molecular onset of MS. Jeannette says it’s
was 22 when I was first diagnosed profiling is vital to unravelling the an important step to proving that a
back in the late 1960s.” mysteries surrounding MS. As a major risk factor can be modified.
Since 2007, Glenda has been married couple, it consumes their “Although a cure might not yet
a patient and trial participant for thoughts long after office hours. be in our grasp, we can now define
Associate Professor Jeannette “When you’re as involved in your so many treatment pathways and
Lechner-Scott, Senior Staff work as Rodney and I am, you don’t interventions that my aim is to see
Specialist in Neurology at John leave anything behind,” Jeannette MS patients going about their daily
Hunter Hospital. says. “You think about it when you life without the disease being a major
Jeannette is tackling MS at the walk the dog or go for a bike ride.” burden on them,” she said.
www.hmri.com.au
Follow HMRI on
Facebook and Twitter
2. community
RADAR on target
A
w
H ds
ar
M N
R ig
I h
t
Top honour for ‘all-rounder’
A Hunter prostate cancer trial using hormone
therapy to reduce testosterone levels – in
conjunction with radiotherapy – has yielded
The Hunter Region’s most ABOVE: Richard Anicich from
promising clinical results, according to chief Sparke Helmore, John Attia,
prestigious medical research
investigator Professor Jim Denham. and NBN’s Deborah Wright.
award has been won by a
The initial findings of the RADAR
multidisciplinary epidemiologist duties and a contribution rate of
(Randomised Androgen Deprivation and
working in fields as diverse as almost one medical publication
Radiotherapy) Trial were published recently
asthma, cancer, diabetes, heart per week; five of his most
in The Lancet Oncology.
disease, mental health, public recent papers appeared in the
Quality-of-life effects were studied in
health and stroke. respected international journal
a cohort of 1000 men across 23 cancer
Professor John Attia accepted Nature Genetics.
centres in Australia and New Zealand.
the coveted Sparke Helmore/ He currently serves as Chief
“We’re aiming to see whether 18 months of
NBN Television Triathlon Award Investigator for the Hunter
hormone therapy is superior to the standard
for Research Excellence in a Community Study, a cohort of
six months of treatment,” Jim said.
ceremony at the HMRI Building 3,000 men and women aged
“The study is also testing whether use of
in late November. 55-85 years that has ongoing
the drug Zometa can prevent losses in bone
As a member of HMRI’s research value in the areas of
mineral density and also prevent the spread
Information Based Medicine genetics and ageing.
of secondary cancers into the skeleton.
and Public Health Programs, In addition to his research,
“We obviously want better treatment
John’s expertise in research John runs an advanced training
outcomes but not at the price of severe
methodology, analysis and program in General Medicine at
side effects. I am highly encouraged by the
molecular genetics is widely John Hunter Hospital.
quality-of-life findings.”
sought by researchers around “John is a thoroughly deserving
Cancer-related outcomes of the RADAR
Australia and the world. winner and joins a very
trial won’t be known until 2014, however
“Studies must be designed impressive HMRI honour board
Jim said that androgen deprivation had
in such a way that they get that dates back to 1999,” HMRI
previously been shown to destroy millions of
accurate results,” John said. Director Michael Nilsson said.
cancer cells which otherwise would thrive on
“To give a classic example, “His work has direct benefit to
testosterone.
there was a study looking at public health outcomes across
The downside was that men experienced
the link between smoking and our communities, and building
temporary symptoms similar to menopause.
Alzheimers Disease, which capacity in our health services.”
“In around one quarter of men, side effects
initially found that smoking was HMRI Chairman Bob Kennedy
from androgen deprivation can be quite
protective. praised the variety and quality
severe, with hot sweats, swelling of breasts,
“What the study didn’t factor in, of work being undertaken by
a reduction in libido and erectile dysfunction,”
though, was that many smokers researchers.
he said. “But we found that the additional
had died earlier, before they had “In addition to the major
12 months of hormone therapy had little
a chance to develop Alzheimers. awards, we were able to present
long-term impact compared to the standard
When the epidemiology was a further ten travel prizes funded
treatment. The majority of men returned to
done correctly, the finding was by HMRI, PULSE and the Hunter
normal once the therapy ceased.”
actually reversed.” Children’s Research Foundation
RADAR was kick-started by a donation
John juggles an extraordinary to help our younger researchers
from HMRI supporters, the Gusse family.
work load with teaching advance their careers,” he said.
3. news in brief
Four new gene
regions linked to
endometriosis have
been discovered
in an international
study involving HMRI
researchers.
The study of 5648
Australian, Japanese
and European women with endometriosis
gives a clearer picture of the causes of this
gynaecological condition, which affects up to
Luke Wolfenden, left, Rebecca 10 per cent of Australian women and causes
Wilson from PULSE, and travel about half of all female infertility.
award winner Morgan James. The condition can also induce pelvic pain,
menstrual disturbance, and tissue damage.
Newcastle researchers Professor Rodney
Good for life ... fruit and vegetable consumption
among children.
Scott, Dr Elizabeth Holliday, Professor John
Attia and Dr Mark McEvoy assisted the
good for Luke Another current trial aims to
encourage greater physical
Queensland Institute of Medical Research.
“This is a major genetic discovery for
activity among children in such a complex disease, which will help in
Also at the HMRI Awards Night, childcare. building risk profiles,” Rodney Scott said.
Public Health research fellow Dr A computer-based smoking
intervention continues to operate A drug widely used to
Luke Wolfenden was named the
at John Hunter Hospital five treat pain and epilepsy
PULSE Early Career Researcher
years after his research ended. can substantially reduce
of the Year. the severity of long-
Luke, 32, works with Hunter Another first was the trial of
term chronic coughing,
New England Population Health a sporting club intervention according to a new
at the Wallsend campus and is to reduce at-risk alcohol study conducted by Dr
a conjoint senior lecturer at the consumption. Through the Nicole Ryan.
University of Newcastle. Australian Drug Foundation it has Her findings are
His far-reaching research reached 5000 clubs nationwide. the first to show that the drug Gabapentin
has significant public health “Receiving the award has been suppresses a nerve-related trigger
relevance as it delves into humbling,” Luke said. “It has responsible for stimulating persistent
smoking cessation, alchohol brought a sense of achievement coughing. “The results are very promising
and renewed determination to and raise hope for many people with
abuse and obesity prevention.
refractory chronic cough,” Nicole said.
He successfully managed conduct innovative research to
“The condition can be both
Australia’s largest child obesity improve community health.”
psychologically and physically disabling,
prevention program, “Good For PULSE also presented travel and there have been no effective drugs
Kids, Good For Life”, and also awards to Morgan James and available. Sufferers now have a potential
conducted the first trial of a Kirsty Pringle, allowing them to new treatment option.”
telephone program to promote attend overseas conferences.
Dr Kenneth Moss
State awards for scientists AM, a foundation board
member of the Hunter
Two past HMRI Award for Research Excellence winners have Medical Research
been acknowledged in the 2012 NSW Science and Engineering Institute from 1998 to
awards announced in Sydney. 2002, passed away
Laureate Professor John Aitken was named NSW Scientist of suddenly in October,
the Year for his world-leading work in reproductive biology. just months after being
“Each year the reproductive needs of some 120 million couples appointed the University
worldwide go unmet. Finding more effective ways to control of Newcastle’s 6th Chancellor.
fertility is a critical global issue while, at an individual level, we Dr Moss headed a Capital Campaign
should never forget the large number of couples seeking safe, that yielded significant funding for the HMRI
effective solutions to their infertility,” Professor Aitken said. Building. He was deeply committed to the
Fellow University of Newcastle researcher Laureate Professor University, having graduated with a Bachelor
Paul Foster won the Excellence in Biological Sciences (Human of Engineering degree (Hons) in 1968 and a
and Animal Health) award for his work in respiratory disease. PhD in mechanical engineering in 1974.
4. events
U t
C et
P
I n
R in
M M
H rd
O
Extra-Ord-inary finish to race
Eight yachts crewed by
HMRI supporters enjoyed a
Fensom’s Long Time Dead,
while third across the line was
Dungog bike ride
magnificent day’s sailing on Wizzard owned by Mic Hinchey. Member for Newcastle, Tim Owen AM MP,
Newcastle Harbour, contesting “The HMRI Cup is a great way went along for the ride when the third annual
the Ord Minnett HMRI Cup. for NCYC to partner with Hunter Newcastle to Dungog Charity Bike Ride
With sponsor Ord Minnett’s Medical Research Institute and began on October 27.
crew aboard, the 43-footer help raise funds for the great After flagging away the lead riders
Anger Management came from work they do across a variety from Nobbys Beach at 6.30am, the State
last place in a handicap start to of research fields,” NCYC parliamentarian hopped on a borrowed
clinch victory by a nose. Chief Executive Officer Richard bicycle and rode the first section of the
It was the closest finish in Howard said. picturesque 90km course.
the club’s history, according to “This year the weather gods “It has been quite a few years since I last
winning skipper Phil Arnall, the were kind, allowing for some hopped on a pushbike but I enjoyed taking
Club Commodore. great racing and a fabulous after part,” Mr Owen said.
Second place went to Matt party back at NCYC.” “I like the idea of a healthy activity like
cycling helping to fund medical research
through HMRI, so I take my hat off to all the
riders who competed.”
The event raised around $15,000 as some
220 riders – ranging from elite racers through
to the so-called “charleys” – formed an
impressive peloton.
The route takes in four local government
areas – Newcastle, Port Stephens, Great
Lakes and Dungog – as it wends its way to
the foothills of Barrington.
“It’s a unique event in the Hunter, being
slightly longer than the Loop The Lake
and following a course through beautiful
countryside that riders don’t often see,” event
spokesman Ian Bourne said.
Rotary members served as marshals and
also greeted the riders upon crossing the
Coming in 2013! finish line at Dungog’s Jubilee Park.
See www.hmri.com.au for more details.
Dec-Jan 20 Maitland Regional Art Gallery is hosting the HMRI
artist in residence Judith White.
Jan 26 PULSE Australia Day party Lot 1, Kookaburra Cct
New Lambton
Feb 22 HMRI Golf Day
Newcastle Golf Course Locked Bag 1000
New Lambton
Mar 17 20th Sparke Helmore/NBN Television triathlon NSW 2305
incorporating the Greater Foreshore 5 (Mar 15) T 02 4042 0000
and Tri-junior triathlon (Mar 16) F 02 4042 0001
E info@hmri.com.au
SEE OUR WEBSITE FOR FULL DETAILS ABN 27 081 436 919
5. Your support helps
fund life-changing
research!
You can make a real difference
Having spent his working life dispensing good
medicine and good advice, pharmacist Vic Carroll
had a healthy respect for his own wellbeing when
he reached retirement. Just as well …
His regular PSA checks began showing a steady
increase and when the reading reached 6.6, Vic’s
GP referred him to a urologist. A biopsy confirmed
that further treatment was warranted.
“The ‘ray’ treatment went for seven weeks, five
days a week, but I’d drive to Waratah, have my
treatment and be home in an hour,” the Merewether
resident said.
In addition to radiotherapy
Vic received an androgen
deprivation (AD) drug in the
RADAR trial (see page 2).
Now aged 74, Vic has
annual appointments with
Professor Jim Denham and
just received his five-year
all-clear.
“In the Hunter we found
that testing rates had
soared after the ‘Little Prick’ campaign
and, as a result, our detection rate became the
highest in the State according to the NSW Cancer
registry,” Jim Denham said, before adding that early
diagnosis by itself won’t save lives.
Close to 3,300 Australian men succumb to prostate
cancer each year but through research they have a
fighting chance. Jim Denham reported that the use
of six months of AD had reduced prostate cancer
death rates 10 years after treatment from 22% to
11.4% in the trial’s predecessor (TROG 96.01).
As part of the RADAR trial, Vic also took the drug
Zometa but he stopped the medication after it flared
up his gout. Today, he plays tennis three times a
week, walks and gardens.
“Thanks to more effective treatments, that have
been ‘road tested’ in our trials program, we hope
to see the Hunter’s mortality rate, which has been
the highest in NSW for many years, dropping in the
next three or four years,” Jim said.
You can help make life better for cancer
patients like Vic. Please donate today by
completing the form overleaf, or online.
www.hmri.com.au
6. Yes!
I would like to make a
donation in support of
life changing research!
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