Professor Yoshihide Hayashizaki, Program Director, Preventative Medicine and Diagnosis Innovation
Program, RIKEN, Japan. http://www.garvan.org.au/news-events/leaders-in-science-and-society
Speaker/Presenter: Mukul Ranjan, Ph.D
Office of Technology Development
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Bethesda, Maryland
TARGETED EPIGENETIC THERAPIES: THE NEXT FRONTIER? AND ADN TECHNOLOGY AND EV...julianacaro12
This document contains two articles summarized by a medical student. The first article discusses targeted epigenetic therapies and how modifying the epigenome through enzymes like EZH2 and UTX may help treat cancer progression. The second article discusses how DNA sequencing and digital storage of genetic information has extended the central dogma to include predicting phenotypes in silico and engineering synthetic biology. The student believes these advances can help control diseases and abnormalities if used for therapeutic purposes.
Cancer breakthrough Sydney scientists record near complete elimination in mal...Himanshu Brahmbhatt
Sydney scientists have achieved stunning survival rates in dogs with late stage brain tumors using a "trojan horse" therapy involving bacterially derived nanocells that target and kill tumor cells. The therapy has also shown near complete elimination of cancer in a male mesothelioma patient. Results to be published this week show the reversal of adverse brain tumor symptoms in dogs, with tumors disappearing in four dogs. The biotech company's therapy can destroy drug-resistant tumor cells, boosting patients' immune systems and allowing some patients to survive two years or longer compared to a normal expectancy of four months.
This document summarizes two genetic studies on cancer. The first study mapped genetic mutations in cutaneous melanoma and identified four subtypes. It also found a protein related to immune response that is overexpressed in melanoma cells. The second study linked a genetic variation in the FOPNL gene to poorer survival rates in multiple myeloma patients, but the mechanism is still unknown. Both studies help locate genes of interest and their variations in diseases, which can inform targeted cancer therapies and improve patient outcomes.
TreatmentMAP™
TreatmentMAP supports physicians in optimizing their treatment decisions, even for cancer patients in advanced stages of cancer, or when all of the standard treatment options for a patient have been exhausted.
Analysis Analysis Analysis Analysisof the entire entire entire protein protein proteinproteincomplementcomplement complement complement of acell, cell, tissue, tissue, tissue, or organism organism organism under under aspecific, specific, specific, defined defined set of conditions conditions conditions .
• Relies Relies Relies on 3basic technological technological technological technological technological cornerstones cornerstones cornerstones cornerstones
• MethodMethod MethodMethod to fractionatefractionate fractionatefractionate fractionatefractionate complexcomplex complex protein/protein/ protein/ protein/ peptide peptide peptidemixturesmixtures mixtures
• MS to acquire acquire the data data necessary necessary to identify identify identifyidentifyindividual individual individual individualproteins proteins
• Bioinformatics Bioinformatics Bioinformatics Bioinformatics Bioinformatics Bioinformatics Bioinformaticsto analyze analyze and assemble assemble the MS data
Do workers work enough? International comparison of working hours and wage di...Malte Nyfos Mathiasen
This document is a paper written by Malte Nyfos Mathiasen for Professor Annette Bernhardt at the University of California, Berkeley. The paper reviews literature on working hours in selected OECD countries since the 1970s, with a focus on the United States. It finds that working hours have stagnated or decreased for low-income workers in the U.S. but increased for high-income workers. The paper aims to conduct an international comparison to see if these trends are also observed in other developed nations and how working hours relate to wage inequality across countries.
Speaker/Presenter: Mukul Ranjan, Ph.D
Office of Technology Development
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Bethesda, Maryland
TARGETED EPIGENETIC THERAPIES: THE NEXT FRONTIER? AND ADN TECHNOLOGY AND EV...julianacaro12
This document contains two articles summarized by a medical student. The first article discusses targeted epigenetic therapies and how modifying the epigenome through enzymes like EZH2 and UTX may help treat cancer progression. The second article discusses how DNA sequencing and digital storage of genetic information has extended the central dogma to include predicting phenotypes in silico and engineering synthetic biology. The student believes these advances can help control diseases and abnormalities if used for therapeutic purposes.
Cancer breakthrough Sydney scientists record near complete elimination in mal...Himanshu Brahmbhatt
Sydney scientists have achieved stunning survival rates in dogs with late stage brain tumors using a "trojan horse" therapy involving bacterially derived nanocells that target and kill tumor cells. The therapy has also shown near complete elimination of cancer in a male mesothelioma patient. Results to be published this week show the reversal of adverse brain tumor symptoms in dogs, with tumors disappearing in four dogs. The biotech company's therapy can destroy drug-resistant tumor cells, boosting patients' immune systems and allowing some patients to survive two years or longer compared to a normal expectancy of four months.
This document summarizes two genetic studies on cancer. The first study mapped genetic mutations in cutaneous melanoma and identified four subtypes. It also found a protein related to immune response that is overexpressed in melanoma cells. The second study linked a genetic variation in the FOPNL gene to poorer survival rates in multiple myeloma patients, but the mechanism is still unknown. Both studies help locate genes of interest and their variations in diseases, which can inform targeted cancer therapies and improve patient outcomes.
TreatmentMAP™
TreatmentMAP supports physicians in optimizing their treatment decisions, even for cancer patients in advanced stages of cancer, or when all of the standard treatment options for a patient have been exhausted.
Analysis Analysis Analysis Analysisof the entire entire entire protein protein proteinproteincomplementcomplement complement complement of acell, cell, tissue, tissue, tissue, or organism organism organism under under aspecific, specific, specific, defined defined set of conditions conditions conditions .
• Relies Relies Relies on 3basic technological technological technological technological technological cornerstones cornerstones cornerstones cornerstones
• MethodMethod MethodMethod to fractionatefractionate fractionatefractionate fractionatefractionate complexcomplex complex protein/protein/ protein/ protein/ peptide peptide peptidemixturesmixtures mixtures
• MS to acquire acquire the data data necessary necessary to identify identify identifyidentifyindividual individual individual individualproteins proteins
• Bioinformatics Bioinformatics Bioinformatics Bioinformatics Bioinformatics Bioinformatics Bioinformaticsto analyze analyze and assemble assemble the MS data
Do workers work enough? International comparison of working hours and wage di...Malte Nyfos Mathiasen
This document is a paper written by Malte Nyfos Mathiasen for Professor Annette Bernhardt at the University of California, Berkeley. The paper reviews literature on working hours in selected OECD countries since the 1970s, with a focus on the United States. It finds that working hours have stagnated or decreased for low-income workers in the U.S. but increased for high-income workers. The paper aims to conduct an international comparison to see if these trends are also observed in other developed nations and how working hours relate to wage inequality across countries.
Vé máy bay vietnam airlines tân sân nhất đi washington giá rẻthuy03baydep
Washington, D.C. là thủ đô của Hoa Kỳ, được thành lập vào ngày 16 tháng 7 năm 1790. Mang tên chính thức District of Columbia (viết tắt D.C.), có nghĩa Đặc khu Columbia, thành phố này còn thường được gọi là Washington, the District, hoặc đơn giản hơn D.C. Trong tiếng Việt, District of Columbia cũng được dịch là Quận Columbia nhưng dễ nhầm lẫn vì có đến 8 quận tại Hoa Kỳ mang tên Columbia, đặc biệt nhất là quận Columbia, Washington, một quận nằm trong tiểu bang Washington. Về địa vị chính trị thì Washington, D.C. được xem là gần như tương đương với các tiểu bang của Hoa Kỳ.
This document provides a summary of Ramy El Hachem's qualifications and professional experience. El Hachem is a Lebanese industrial engineer with experience in materials management, waste management, automated baggage handling systems, and computer applications. His professional experience includes working on projects such as aircraft maintenance hangars in Saudi Arabia, cargo facilities at Dubai International Airport, and regional specialized hospitals in Saudi Arabia. He has participated in the design, review, and supervision of industrial systems for these various infrastructure projects.
Khan Resources, a Canadian mining company, has filed a CAD300 million lawsuit against Russian state-owned uranium company ARMZ and its subsidiary for damages resulting from interfering with Khan's economic interests and rights in Mongolia. Specifically, Khan alleges that ARMZ sought to establish its own joint venture over the Dornod uranium region in Mongolia without regard for Khan's existing rights, impugned the legitimacy of Khan's interests, and interfered with a competing acquisition offer, all with the goal of eliminating Khan's Mongolian assets. Khan states it was forced to file the lawsuit in order to protect its rights and seek compensation for the substantial damages caused by ARMZ.
The document discusses 10 factors that impact team effectiveness and professional behaviors: outcomes, culture, bringing people together, flexibility in success strategies, situational leadership, attitude, self-awareness, communication, personal narratives, and focus on others. Effective professionals focus on results, build a cooperative culture, adapt their approach based on the situation, and prioritize team success over their own agenda.
El documento discute los beneficios de la risa para la salud y el bienestar. La risa reduce el estrés, estimula las "hormonas de la felicidad" y fortalece el sistema inmunológico. Aunque la risa es natural y segura, aplicarla como tratamiento terapéutico requiere cuidado para evitar efectos negativos como la histeria. La risa es más efectiva cuando se combina con ejercicios de yoga y meditación para inducir un profundo estado de relajación.
The document summarizes costume designs for several characters in a film. For the character Kevin, who is the victim of an abduction, the designer chose a casual look of a red shirt, blue denim trousers, and suede shoes to present him as an unexpected victim. For the character Felix, a contract killer, the designer chose a full designer suit to portray him as professional and taking pride in his work. The character Mullet is meant to be comedic, so his costume needs to represent that. Austin's costume is identical to Felix's to show that they represent the same things for the audience.
The document discusses how the media product uses and challenges conventions of real media forms.
It summarizes how the music video uses settings like a house, park, and bedroom to tell the story of a deteriorating relationship, drawing on conventions from real music videos. It also discusses costume and prop choices meant to portray the characters and advance the narrative.
The editing, camera work, and visual style are described as conforming to or challenging conventions of real R&B music videos. Specifically, it challenges conventions by focusing on the female character and portraying her as strong and dominant rather than weak.
The magazine ad and album packaging are said to challenge conventions by not showing the artist's face and focusing more on his
Faridabad in an industrial city in the state of Haryana and is located to the south of national capital New Delhi. As per the master plan 2031 prepared by Town and Country Planning Department (TCPD) of Haryana, the city’s population will grow to 3886407 by 2031 from 1438855 in 2011. Find the proposed land uses in this master plan 2031 Faridabad.
Este documento resume las diferencias entre las principales sociedades mercantiles en Venezuela de acuerdo con el Código de Comercio, incluyendo las sociedades de nombre colectivo, sociedad anónima, sociedades de responsabilidad limitada y sociedades en comandita. Explica las características clave, responsabilidades de los socios y requisitos legales de cada tipo de sociedad mercantil.
Dermatología Generalidades y tratamientoDiego Lizama
1) La micosis superficial más común es la candidiasis, causada por Candida albicans, que puede afectar la piel, mucosas u órganos. Las formas sistémicas o profundas se atribuyen a catéteres intravenosos.
2) La pitiriasis versicolor es causada por Malassezia sp. y se caracteriza por manchas hipo o hipercromáticas en el tronco.
3) Las tiñas o dermatofitosis son causadas por hongos queratinolíticos como Trichophyton, Microsp
This document contains information about the International Conference and Exhibition on Nanomedicine and Drug Delivery that will take place from May 29-31, 2017 in Osaka, Japan. It includes the tentative program agenda, speaker biographies, organizing committee members, and registration information. The conference will feature keynote lectures, interactive sessions, workshops, and tracks on topics related to nanomedicine and drug delivery over the three-day event.
Here are 15 Biopharma research trends to watch in 2023; 1. Epitranscriptomics 2. mRNA vaccines and RNA therapies 3. Drug development using deep learning and large datasets 4. Neoantigens 5. Targeting RNA with small molecules 6. Theranostics 7. Exosomes 8. Synthetic Biology 9. Gene Editing 10. Antibiotics “anti-trend” 11. Nanotechnologies in Drug Delivery 12. Aging research 13. 3-D Bioprinting 14. Microbiome 15. Protein Degraders
1. Radiotherapy targeting only para-aortic nodes is insufficient for testicular seminoma patients with a history of pelvic or scrotal surgery, as the primary lymphatic drainage pattern may have been altered.
2. For these cases, the treatment plan should include ipsilateral iliac and inguinal nodes in classic dog-leg AP-PA fields.
3. Prophylactic irradiation of the contralateral iliac, inguinal, or scrotal region may also be indicated for prior maldescensus testis, inguinal or scrotal violation, or pT3/4 primary tumors.
role of nanotechonolgy in diagnostic pathology.pptxBVDUPathology1
Nanotechnology involves engineering materials and devices on the nanoscale (1-100 nm) and can be applied to diagnostic pathology. It allows for early disease detection by taking advantage of nanoparticles' high surface area and ability to interact with biomolecules. Common nanodiagnostic techniques include magnetic nanoparticles for MRI contrast, nanochips for DNA analysis, microfluidics to automate biochemical assays, and nanoarrays for high-throughput screening of proteins and nucleic acids. Future applications may integrate multiple functions like imaging, detection, targeted drug delivery, and treatment monitoring into single nanodevices.
NEXT GENERATION SEQUENCING IN DETECTING ORAL CANCER DUE TO TOBACCO CONSUMPTIONbioejjournal
DNA sequence DNA Sequencing is the first step in establishing phylogenetic trees, protein structure
prediction, diagnosis of cancer, discovery of drugs and hence its importance cannot be underestimated.
DNA sequencing finds its use in the diagnosis of oral squamous cell carcinoma (OSCC). Oral Cancer is
the most common occurring malignancies in the world, especially in India where the prevalence for
smoking, Areca nut chewing coupled with a lifestyle that encourages these two activities as fashion are left
many people diagnosed with OSCC. Patients with this OSCC are more likely unaware of its side effects
and over time might suffer from facial deformity. The importance to understanding the symptoms,
prevention and treatment of oral cancer is very much essential today. In this paper, we looked at over 2000
odd papers published and look at the correlation between the next Generation DNA sequencing algorithms
(NGS) play an important role in diagnosis of OSCC. This is a further study on some of the papers which
have highlighted NGS role in OSCC Diagnosis. We did like to see a comprehensive review on the papers
published so far. In the discussion, we will see frequently mutated genes in the OSCC, recent discoveries
and OSCC treatment based on the findings.
Next Generation Sequencing in Detecting Oral Cancer Due to Tobacco Consumptionbioejjournal
DNA sequence DNA Sequencing is the first step in establishing phylogenetic trees, protein structure
prediction, diagnosis of cancer, discovery of drugs and hence its importance cannot be underestimated.
DNA sequencing finds its use in the diagnosis of oral squamous cell carcinoma (OSCC). Oral Cancer is
the most common occurring malignancies in the world, especially in India where the prevalence for
smoking, Areca nut chewing coupled with a lifestyle that encourages these two activities as fashion are left
many people diagnosed with OSCC. Patients with this OSCC are more likely unaware of its side effects
and over time might suffer from facial deformity. The importance to understanding the symptoms,
prevention and treatment of oral cancer is very much essential today. In this paper, we looked at over 2000
odd papers published and look at the correlation between the next Generation DNA sequencing algorithms
(NGS) play an important role in diagnosis of OSCC. This is a further study on some of the papers which
have highlighted NGS role in OSCC Diagnosis. We did like to see a comprehensive review on the papers
published so far. In the discussion, we will see frequently mutated genes in the OSCC, recent discoveries
and OSCC treatment based on the findings.
The document discusses how technology has helped shed light on cancer through research using large facilities like synchrotron radiation and neutron laboratories. Over 100,000 protein structures have been determined using these techniques to better understand biochemical processes and design drugs. Countries are investing in new facilities to advance scientific development and tackle challenges like cancer. Nanotechnology and drug delivery systems combined with characterization techniques can improve cancer treatment methods.
This document discusses the emerging field of Theranostics, which combines therapeutics and diagnostics for personalized treatment. Some key points:
1) Theranostics uses targeted drug delivery and imaging techniques to first diagnose a condition and then deliver the appropriate treatment. This allows for precision medicine tailored to individual patients.
2) While still nascent in India, Theranostics has potential to grow as the population is genetically diverse. It may first be used for cancers and other serious diseases.
3) Barriers to adoption in India include cost, lack of infrastructure and expertise, and need for collaboration between academia, industry and clinicians. Education is also needed for doctors, patients and regulators.
Vé máy bay vietnam airlines tân sân nhất đi washington giá rẻthuy03baydep
Washington, D.C. là thủ đô của Hoa Kỳ, được thành lập vào ngày 16 tháng 7 năm 1790. Mang tên chính thức District of Columbia (viết tắt D.C.), có nghĩa Đặc khu Columbia, thành phố này còn thường được gọi là Washington, the District, hoặc đơn giản hơn D.C. Trong tiếng Việt, District of Columbia cũng được dịch là Quận Columbia nhưng dễ nhầm lẫn vì có đến 8 quận tại Hoa Kỳ mang tên Columbia, đặc biệt nhất là quận Columbia, Washington, một quận nằm trong tiểu bang Washington. Về địa vị chính trị thì Washington, D.C. được xem là gần như tương đương với các tiểu bang của Hoa Kỳ.
This document provides a summary of Ramy El Hachem's qualifications and professional experience. El Hachem is a Lebanese industrial engineer with experience in materials management, waste management, automated baggage handling systems, and computer applications. His professional experience includes working on projects such as aircraft maintenance hangars in Saudi Arabia, cargo facilities at Dubai International Airport, and regional specialized hospitals in Saudi Arabia. He has participated in the design, review, and supervision of industrial systems for these various infrastructure projects.
Khan Resources, a Canadian mining company, has filed a CAD300 million lawsuit against Russian state-owned uranium company ARMZ and its subsidiary for damages resulting from interfering with Khan's economic interests and rights in Mongolia. Specifically, Khan alleges that ARMZ sought to establish its own joint venture over the Dornod uranium region in Mongolia without regard for Khan's existing rights, impugned the legitimacy of Khan's interests, and interfered with a competing acquisition offer, all with the goal of eliminating Khan's Mongolian assets. Khan states it was forced to file the lawsuit in order to protect its rights and seek compensation for the substantial damages caused by ARMZ.
The document discusses 10 factors that impact team effectiveness and professional behaviors: outcomes, culture, bringing people together, flexibility in success strategies, situational leadership, attitude, self-awareness, communication, personal narratives, and focus on others. Effective professionals focus on results, build a cooperative culture, adapt their approach based on the situation, and prioritize team success over their own agenda.
El documento discute los beneficios de la risa para la salud y el bienestar. La risa reduce el estrés, estimula las "hormonas de la felicidad" y fortalece el sistema inmunológico. Aunque la risa es natural y segura, aplicarla como tratamiento terapéutico requiere cuidado para evitar efectos negativos como la histeria. La risa es más efectiva cuando se combina con ejercicios de yoga y meditación para inducir un profundo estado de relajación.
The document summarizes costume designs for several characters in a film. For the character Kevin, who is the victim of an abduction, the designer chose a casual look of a red shirt, blue denim trousers, and suede shoes to present him as an unexpected victim. For the character Felix, a contract killer, the designer chose a full designer suit to portray him as professional and taking pride in his work. The character Mullet is meant to be comedic, so his costume needs to represent that. Austin's costume is identical to Felix's to show that they represent the same things for the audience.
The document discusses how the media product uses and challenges conventions of real media forms.
It summarizes how the music video uses settings like a house, park, and bedroom to tell the story of a deteriorating relationship, drawing on conventions from real music videos. It also discusses costume and prop choices meant to portray the characters and advance the narrative.
The editing, camera work, and visual style are described as conforming to or challenging conventions of real R&B music videos. Specifically, it challenges conventions by focusing on the female character and portraying her as strong and dominant rather than weak.
The magazine ad and album packaging are said to challenge conventions by not showing the artist's face and focusing more on his
Faridabad in an industrial city in the state of Haryana and is located to the south of national capital New Delhi. As per the master plan 2031 prepared by Town and Country Planning Department (TCPD) of Haryana, the city’s population will grow to 3886407 by 2031 from 1438855 in 2011. Find the proposed land uses in this master plan 2031 Faridabad.
Este documento resume las diferencias entre las principales sociedades mercantiles en Venezuela de acuerdo con el Código de Comercio, incluyendo las sociedades de nombre colectivo, sociedad anónima, sociedades de responsabilidad limitada y sociedades en comandita. Explica las características clave, responsabilidades de los socios y requisitos legales de cada tipo de sociedad mercantil.
Dermatología Generalidades y tratamientoDiego Lizama
1) La micosis superficial más común es la candidiasis, causada por Candida albicans, que puede afectar la piel, mucosas u órganos. Las formas sistémicas o profundas se atribuyen a catéteres intravenosos.
2) La pitiriasis versicolor es causada por Malassezia sp. y se caracteriza por manchas hipo o hipercromáticas en el tronco.
3) Las tiñas o dermatofitosis son causadas por hongos queratinolíticos como Trichophyton, Microsp
This document contains information about the International Conference and Exhibition on Nanomedicine and Drug Delivery that will take place from May 29-31, 2017 in Osaka, Japan. It includes the tentative program agenda, speaker biographies, organizing committee members, and registration information. The conference will feature keynote lectures, interactive sessions, workshops, and tracks on topics related to nanomedicine and drug delivery over the three-day event.
Here are 15 Biopharma research trends to watch in 2023; 1. Epitranscriptomics 2. mRNA vaccines and RNA therapies 3. Drug development using deep learning and large datasets 4. Neoantigens 5. Targeting RNA with small molecules 6. Theranostics 7. Exosomes 8. Synthetic Biology 9. Gene Editing 10. Antibiotics “anti-trend” 11. Nanotechnologies in Drug Delivery 12. Aging research 13. 3-D Bioprinting 14. Microbiome 15. Protein Degraders
1. Radiotherapy targeting only para-aortic nodes is insufficient for testicular seminoma patients with a history of pelvic or scrotal surgery, as the primary lymphatic drainage pattern may have been altered.
2. For these cases, the treatment plan should include ipsilateral iliac and inguinal nodes in classic dog-leg AP-PA fields.
3. Prophylactic irradiation of the contralateral iliac, inguinal, or scrotal region may also be indicated for prior maldescensus testis, inguinal or scrotal violation, or pT3/4 primary tumors.
role of nanotechonolgy in diagnostic pathology.pptxBVDUPathology1
Nanotechnology involves engineering materials and devices on the nanoscale (1-100 nm) and can be applied to diagnostic pathology. It allows for early disease detection by taking advantage of nanoparticles' high surface area and ability to interact with biomolecules. Common nanodiagnostic techniques include magnetic nanoparticles for MRI contrast, nanochips for DNA analysis, microfluidics to automate biochemical assays, and nanoarrays for high-throughput screening of proteins and nucleic acids. Future applications may integrate multiple functions like imaging, detection, targeted drug delivery, and treatment monitoring into single nanodevices.
NEXT GENERATION SEQUENCING IN DETECTING ORAL CANCER DUE TO TOBACCO CONSUMPTIONbioejjournal
DNA sequence DNA Sequencing is the first step in establishing phylogenetic trees, protein structure
prediction, diagnosis of cancer, discovery of drugs and hence its importance cannot be underestimated.
DNA sequencing finds its use in the diagnosis of oral squamous cell carcinoma (OSCC). Oral Cancer is
the most common occurring malignancies in the world, especially in India where the prevalence for
smoking, Areca nut chewing coupled with a lifestyle that encourages these two activities as fashion are left
many people diagnosed with OSCC. Patients with this OSCC are more likely unaware of its side effects
and over time might suffer from facial deformity. The importance to understanding the symptoms,
prevention and treatment of oral cancer is very much essential today. In this paper, we looked at over 2000
odd papers published and look at the correlation between the next Generation DNA sequencing algorithms
(NGS) play an important role in diagnosis of OSCC. This is a further study on some of the papers which
have highlighted NGS role in OSCC Diagnosis. We did like to see a comprehensive review on the papers
published so far. In the discussion, we will see frequently mutated genes in the OSCC, recent discoveries
and OSCC treatment based on the findings.
Next Generation Sequencing in Detecting Oral Cancer Due to Tobacco Consumptionbioejjournal
DNA sequence DNA Sequencing is the first step in establishing phylogenetic trees, protein structure
prediction, diagnosis of cancer, discovery of drugs and hence its importance cannot be underestimated.
DNA sequencing finds its use in the diagnosis of oral squamous cell carcinoma (OSCC). Oral Cancer is
the most common occurring malignancies in the world, especially in India where the prevalence for
smoking, Areca nut chewing coupled with a lifestyle that encourages these two activities as fashion are left
many people diagnosed with OSCC. Patients with this OSCC are more likely unaware of its side effects
and over time might suffer from facial deformity. The importance to understanding the symptoms,
prevention and treatment of oral cancer is very much essential today. In this paper, we looked at over 2000
odd papers published and look at the correlation between the next Generation DNA sequencing algorithms
(NGS) play an important role in diagnosis of OSCC. This is a further study on some of the papers which
have highlighted NGS role in OSCC Diagnosis. We did like to see a comprehensive review on the papers
published so far. In the discussion, we will see frequently mutated genes in the OSCC, recent discoveries
and OSCC treatment based on the findings.
The document discusses how technology has helped shed light on cancer through research using large facilities like synchrotron radiation and neutron laboratories. Over 100,000 protein structures have been determined using these techniques to better understand biochemical processes and design drugs. Countries are investing in new facilities to advance scientific development and tackle challenges like cancer. Nanotechnology and drug delivery systems combined with characterization techniques can improve cancer treatment methods.
This document discusses the emerging field of Theranostics, which combines therapeutics and diagnostics for personalized treatment. Some key points:
1) Theranostics uses targeted drug delivery and imaging techniques to first diagnose a condition and then deliver the appropriate treatment. This allows for precision medicine tailored to individual patients.
2) While still nascent in India, Theranostics has potential to grow as the population is genetically diverse. It may first be used for cancers and other serious diseases.
3) Barriers to adoption in India include cost, lack of infrastructure and expertise, and need for collaboration between academia, industry and clinicians. Education is also needed for doctors, patients and regulators.
Nanotechnology for cancer therapy recent developmentsroshan telrandhe
1. The document discusses recent developments in using nanotechnology for cancer therapy. It describes how nanoparticles can be used to target delivery of drugs specifically to tumor cells, reducing side effects on healthy cells.
2. Various nanotechnology platforms for drug delivery are reviewed, including polymeric nanoparticles, liposomes, dendrimers, and nucleic acid-based nanoparticles. The targeted delivery allows for higher drug doses to be used against cancer cells.
3. The review discusses both preventative and treatment applications of nanotechnology. Preventatively, nanoparticles could deliver sunscreen agents directly to skin cells. In treatment, nanoparticles are being used to more effectively deliver drugs like paclitaxel for prostate cancer therapy.
This white paper discusses the potential presence of graphene and its derivatives in mRNA vaccine manufacturing and their physicochemical and toxicological properties. It reviews literature on the use of graphene in biotechnology and as carriers, adjuvants, and purifying agents in mRNA vaccine production. Some independent studies have found graphene-like particles in COVID-19 vaccine vials, while regulatory agencies have not detected them. The paper argues that further verification is needed to definitively determine the presence or absence of graphene using both approved and independent analytical methods. Understanding any contaminants has safety implications given some vaccines' association with rare adverse reactions.
Dr. Syed Javaid Khurshid has extensive experience in project management, planning, and evaluation working for the Pakistan Atomic Energy Commission (PAEC) for 39 years. He has a PhD in chemistry and has managed over 85 projects worth $98 billion at PAEC related to agriculture, biotechnology, energy, engineering, and science and technology. Currently he is the President of the Pakistan Nuclear Society and teaches at various universities in Pakistan.
Prediction of antitubercular_peptides_from_sequencShahidAkbar22
This document describes research on developing machine learning models to predict antitubercular peptides from their amino acid sequences. Tuberculosis is a major global health problem and new therapies are needed due to the emergence of drug-resistant strains. The researchers created datasets of known antitubercular peptides and other peptides to train and test their models. They used different machine learning algorithms and peptide sequence features, such as amino acid composition and terminal residues, as inputs. Their best performing ensemble model achieved 73.2% accuracy at predicting antitubercular peptides. They also created a web server to make the models available to other researchers working on designing new antitubercular peptides.
This document provides an overview of bioinformatics and genomics. It begins with an acknowledgement and abstract section. The introduction defines bioinformatics and its role in analyzing genetic sequences and biological data through computational methods. Major research areas of bioinformatics discussed include sequence analysis, genome annotation, evolutionary biology, measuring biodiversity, gene expression analysis, protein analysis, cancer mutation analysis, and protein structure prediction. Comparative genomics and modeling biological systems are also summarized. The document concludes with a definition of genomics as the study of genomes through sequencing efforts and mapping genetic interactions.
Genomics is the study of an organism's entire genome, including all genes and their interactions. It involves sequencing genomes and analyzing genes at the DNA, mRNA, and protein levels. The goals of genomics include sequencing entire genomes and understanding gene expression. Key applications include medical diagnosis and treatment, agriculture, evolution studies, and forensic science. Genomics played an important role in understanding COVID-19 by providing insights into the virus's origins, transmission, and potential therapies.
The Significance of Lifescience- An In-depth Exploration.pdfhealthcare360social
Lifescience, an expansive and dynamic domain, unveils the enigmas of living organisms and their intricate connections with the environment. Its impact spans from molding pivotal medical advancements to influencing initiatives in conservation.
Medical nanotechnology 2017 Scientific ProgramJasmin Keith
This document provides information about the 15th World Medical Nanotechnology Congress taking place on October 18-19, 2017 in Osaka, Japan. The conference will focus on advances in nanomedicine for diagnosis and theranostics. It includes the conference program, speaker and topic details, registration information, and accommodation details at the Hyatt Regency Osaka. Attendees will learn about the latest developments and applications of nanotechnology in areas like drug delivery, cancer treatment, biomaterials and more.
This document discusses using information and communication technologies (ICT) to support global biomedical research infrastructure. It outlines:
1) How new data types from areas like genomics and nanomedicine are being generated at unprecedented scales and need to be collected, integrated and analyzed using distributed computing.
2) Issues around using electronic health records and research data to model human physiology and disease.
3) Participants in the discussion including experts from Microsoft, Spanish and Belgian universities who will discuss using ICT to advance personalized and genomic medicine.
M Pharm Pharmacognosy Semester 2, MEDICINAL PLANT BIOTECHNOLOGY UNIT 1, Introduction to Plant biotechnology: Historical perspectives, prospects for development of plant biotechnology as a source of
medicinal agents. Applications in pharmacy and allied fields. Genetic and molecular biology as applied to pharmacognosy, study of DNA, RNA and protein replication, genetic code, regulation of gene expression, structure and complicity of
genome, cell signaling, DNA recombinant technology.
Similar to Leaders in Science and Society - Prof Yoshihide Hayashizaki (20)
Professor Gail Risbridger. Deputy Dean - Special Projects, MpCCC Research Director, Prostate Cancer Research Program, Monash University. http://www.garvan.org.au/news-events/leaders-in-science-and-society
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Leaders in Science and Society - Prof Yoshihide Hayashizaki
1. Garvan Institute of Medical Research
Leaders in Science & Society
Dr Yoshihide Hayashizaki
Program Director, Preventative Medicine and Diagnosis Innovation
Program, RIKEN, Japan
“The recent progress of FANTOM omics,
and its application to health care”
Monday 22 February 2016 12PM, AUDITORIUM
Host: Prof John Mattick
Yoshihide Hayashizaki is Director of Preventive Medicine & Diagnosis Innovation Program. He obtained his M.D. and Ph.D. from Osaka University Medical
School in 1982 and 1986, respectively. In 1992, he joined RIKEN, and was appointed Project Director for the RIKEN Genome Project in 1995. Since then he
has been taken a transversal data-driven approach to analyze transcriptomes by developing unique technologies including a series of full-length cDNA
technologies. With this approach, he has established large amount of full-length cDNA clone bank. This activity was followed by organization of FANTOM
(Functional Annotation of Mammalian Genome), an international consortium, originally to annotate a large number of cDNA and subsequently expanded to
transcriptome and network analysis. FANTOM activities revealed that more than 63% of the genome - not just the ~1.5% fraction that are protein-coding exons
- is transcribed as RNA. His research interests are focused on understanding of biological phenomena as systems at the molecular level and its application to
preventive medical care.