Avida-ED is award winning digital evolution software that provides students with the opportunity to learn fundamental evolutionary concepts while simultaneously engaging in authentic science practices. In this way, Avida-ED is exceptionally well aligned with reform-based teaching practices, such as those advocated by the Next Generation Science Standards and Vision & Change. We present preliminary results of a multiple-case study on the classroom implementation of Avida-ED and its effects on student understanding and acceptance of evolution. Students were assessed prior and subsequent to engagement in exercises involving Avida-ED. Both content understanding and acceptance of evolution as a real phenomenon that explains the diversity of life on earth and is sound, evidence-based science were assessed. We found that students in lower-division biology courses saw significant increases in both understanding and acceptance of evolution after engaging in lessons that used Avida-ED.