The document provides an update from Associates of Cape Cod, Inc. regarding their technical services department and LAL products. It introduces the three members of the technical services department - Laurie Fife, Keith Richardson, and Carmen Barillas - who are available to answer customer questions. It also discusses record harvests of LAL from horseshoe crabs leading to good inventory levels of various LAL products for customers.
The bacterial endotoxin test (BET) uses Limulus amebocyte lysate (LAL) extracted from horseshoe crab blood cells to detect endotoxins from gram-negative bacteria. The LAL contains enzymes that activate and coagulate in the presence of endotoxins, specifically lipopolysaccharides. To perform the BET, test samples are mixed with LAL and a positive control containing a known amount of endotoxin. If the LAL coagulates for the sample but not the negative control, endotoxins are present in the sample at a level depending on the dilution and lysate sensitivity. The test provides a quantitative measure of endotoxins to ensure safety for medical products.
Occupational exposure limits (OEL) to chemical agents APIs - Quantitative Ris...Azierta
The Occupational Exposure Limit (OEL) is defined as the airborne concentration of a substance (expressed as a weighted average in time for a working day of 8 hours/day and 40 hours/working week) under which it is believed that nearly all workers may be repeatedly exposed (day after day, over a working lifetime) without adverse health effects (ACGIH, 2006; DFG, 2005).
Occupational exposure limits (OELs) are a useful tool to prevent adverse effects on health when managing chemical substances.
On a European scale…
• Employers are legally obliged to provide a work environment that does not threaten the health of the workers (Chemical Agent Directive 98/24/EC and Framework Directive 89/391/EEC).
• Under Directive 89/391/EEC, OELs can be developed nationally, Indicative Occupational Exposure Limit Values (IOELVs).
This document reviews the evidence from clinical trials comparing different surfactant preparations used to treat respiratory distress syndrome (RDS) in preterm infants. It discusses the benefits of natural surfactants over synthetic surfactants, noting that natural surfactants contain surfactant proteins SP-B and SP-C which enhance their function. It also summarizes four key clinical trials that directly compared the efficacy of different natural surfactant preparations (Curosurf, Survanta, Infasurf, Alveofact), noting they used different doses and treatment protocols. The document concludes that while natural surfactants are generally preferred to older synthetic preparations, results of trials comparing newer synthetic surfactants to natural surfactants are
The effect of addition NaCI 150 mOsmol pH 7 on liposomes Tetraether Lipid (EP...IjcmsdrJournal
As a drugs carrier, liposome can alter the pharmacokinetics of the entrapped drugs. Thus, drugs can act directly on the targeted cell while their systemic side effects are reduced. To become an effective drugs carrier, liposome must reach its stability in chemical, physical, and biological conditions. Liposome stability can be achieved by changing the lipid composition, such as EPC-TEL 2,5 which is made from the combination of Egg Yolk Phosphatydyl Coline (EPC) and TEL 2,5 mol % that is extracted from Thermoplasma acidofilum. The aim of this study is to test the chemical stability of liposome EPC-TEL 2,5 with sonication by addition of NaCI 150 mOsmol pH 7 solution. The increase in number of liposome larger than 100 nm is the stability parameter in this study. After observation at day 0, 7, 30, 60, 90, there was no significant increase in the number of liposome larger than 100 nm after addition of NaCI 150 mOsmol pH 7 compared with control.
Renal Toxicity Studies of Albino Rats Exposed to Common Emulsion Paint SolutionPremier Publishers
Emulsion paint solutions (EPS) are constantly used to decorate and protect different materials in the environment. The occupational exposure of professional painters and paint factory workers to EPS may predispose them to systemic toxicity. This work investigated the effects of EPS exposure on renal function indices in albino rats to assess potential renal toxicity. Twenty male albino rats weighing between 120-140g were collected and divided into four groups. Two groups were exposed to periodic intraperitoneal administration of 2.5mg/kg body weight (bw) of the EPS for 14days while the other two groups received the same dose of distilled water and served as control. The rats were sacrificed after 7and14days respectively, and their blood collected and analyzed for heavy metals, urea, creatinine and electrolytes, using standard methods. The rat kidneys were also excised, weighed and analyzed for total protein and histopathology. Results showed that bw, kidney weight, serum creatinine, urea and electrolytes decreased significantly(p<0.05) in the exposed groups compared to control. However, urea and Na+ increased significantly(p<0.05) after the initial 7days exposure. Kidney total protein increased by 20.83% and Pb, Ni, and Cd were detected in the exposed rats. Results of kidney histopathology showed intact renal tubules and glomeruli. These results suggest that exposure of albino rats to EPS caused significant alterations in the steady-state levels of renal function biomarkers. Therefore, prolonged exposure may exert deleterious effects on renal function.
Dr. Robert Langer - Simposio Internacional 'Terapias oncológicas avanzadas'Fundación Ramón Areces
Los días 15 y 16 de octubre de 2014, la Fundación Ramón Areces y la Real Academia Nacional de Farmacia, en colaboración con la Fundación de la Innovación Bankinter, reunieron en Madrid a algunos de los mayores expertos mundiales en nuevas terapias contra el cáncer. El Simposio Internacional, coordinado por la profesora y académica María José Alonso, analizó el momento actual de la lucha contra esta enfermedad. También fue un punto de encuentro para científicos de los más innovadores institutos de investigación en oncología, quienes debatieron sobre tres grandes temas: la Medicina Personalizada contra el cáncer, los nanomedicamentos en la terapia del cáncer y las terapias basadas en la inmunomodulación.
This document discusses various treatment options for bronchial asthma and COPD, including short-acting beta agonists, long-acting beta agonists, inhaled corticosteroids, anticholinergics, antileukotrienes, IGE antagonists, PDE inhibitors, and anti-inflammatory drugs. It also discusses smoking cessation options like varenicline, nicotine vaccines, and rimonabant. New long-acting bronchodilators discussed include indacaterol, aclidinium bromide, and NVA237. Combination therapies involving inhaled corticosteroids and long-acting beta agonists are also summarized.
The bacterial endotoxin test (BET) uses Limulus amebocyte lysate (LAL) extracted from horseshoe crab blood cells to detect endotoxins from gram-negative bacteria. The LAL contains enzymes that activate and coagulate in the presence of endotoxins, specifically lipopolysaccharides. To perform the BET, test samples are mixed with LAL and a positive control containing a known amount of endotoxin. If the LAL coagulates for the sample but not the negative control, endotoxins are present in the sample at a level depending on the dilution and lysate sensitivity. The test provides a quantitative measure of endotoxins to ensure safety for medical products.
Occupational exposure limits (OEL) to chemical agents APIs - Quantitative Ris...Azierta
The Occupational Exposure Limit (OEL) is defined as the airborne concentration of a substance (expressed as a weighted average in time for a working day of 8 hours/day and 40 hours/working week) under which it is believed that nearly all workers may be repeatedly exposed (day after day, over a working lifetime) without adverse health effects (ACGIH, 2006; DFG, 2005).
Occupational exposure limits (OELs) are a useful tool to prevent adverse effects on health when managing chemical substances.
On a European scale…
• Employers are legally obliged to provide a work environment that does not threaten the health of the workers (Chemical Agent Directive 98/24/EC and Framework Directive 89/391/EEC).
• Under Directive 89/391/EEC, OELs can be developed nationally, Indicative Occupational Exposure Limit Values (IOELVs).
This document reviews the evidence from clinical trials comparing different surfactant preparations used to treat respiratory distress syndrome (RDS) in preterm infants. It discusses the benefits of natural surfactants over synthetic surfactants, noting that natural surfactants contain surfactant proteins SP-B and SP-C which enhance their function. It also summarizes four key clinical trials that directly compared the efficacy of different natural surfactant preparations (Curosurf, Survanta, Infasurf, Alveofact), noting they used different doses and treatment protocols. The document concludes that while natural surfactants are generally preferred to older synthetic preparations, results of trials comparing newer synthetic surfactants to natural surfactants are
The effect of addition NaCI 150 mOsmol pH 7 on liposomes Tetraether Lipid (EP...IjcmsdrJournal
As a drugs carrier, liposome can alter the pharmacokinetics of the entrapped drugs. Thus, drugs can act directly on the targeted cell while their systemic side effects are reduced. To become an effective drugs carrier, liposome must reach its stability in chemical, physical, and biological conditions. Liposome stability can be achieved by changing the lipid composition, such as EPC-TEL 2,5 which is made from the combination of Egg Yolk Phosphatydyl Coline (EPC) and TEL 2,5 mol % that is extracted from Thermoplasma acidofilum. The aim of this study is to test the chemical stability of liposome EPC-TEL 2,5 with sonication by addition of NaCI 150 mOsmol pH 7 solution. The increase in number of liposome larger than 100 nm is the stability parameter in this study. After observation at day 0, 7, 30, 60, 90, there was no significant increase in the number of liposome larger than 100 nm after addition of NaCI 150 mOsmol pH 7 compared with control.
Renal Toxicity Studies of Albino Rats Exposed to Common Emulsion Paint SolutionPremier Publishers
Emulsion paint solutions (EPS) are constantly used to decorate and protect different materials in the environment. The occupational exposure of professional painters and paint factory workers to EPS may predispose them to systemic toxicity. This work investigated the effects of EPS exposure on renal function indices in albino rats to assess potential renal toxicity. Twenty male albino rats weighing between 120-140g were collected and divided into four groups. Two groups were exposed to periodic intraperitoneal administration of 2.5mg/kg body weight (bw) of the EPS for 14days while the other two groups received the same dose of distilled water and served as control. The rats were sacrificed after 7and14days respectively, and their blood collected and analyzed for heavy metals, urea, creatinine and electrolytes, using standard methods. The rat kidneys were also excised, weighed and analyzed for total protein and histopathology. Results showed that bw, kidney weight, serum creatinine, urea and electrolytes decreased significantly(p<0.05) in the exposed groups compared to control. However, urea and Na+ increased significantly(p<0.05) after the initial 7days exposure. Kidney total protein increased by 20.83% and Pb, Ni, and Cd were detected in the exposed rats. Results of kidney histopathology showed intact renal tubules and glomeruli. These results suggest that exposure of albino rats to EPS caused significant alterations in the steady-state levels of renal function biomarkers. Therefore, prolonged exposure may exert deleterious effects on renal function.
Dr. Robert Langer - Simposio Internacional 'Terapias oncológicas avanzadas'Fundación Ramón Areces
Los días 15 y 16 de octubre de 2014, la Fundación Ramón Areces y la Real Academia Nacional de Farmacia, en colaboración con la Fundación de la Innovación Bankinter, reunieron en Madrid a algunos de los mayores expertos mundiales en nuevas terapias contra el cáncer. El Simposio Internacional, coordinado por la profesora y académica María José Alonso, analizó el momento actual de la lucha contra esta enfermedad. También fue un punto de encuentro para científicos de los más innovadores institutos de investigación en oncología, quienes debatieron sobre tres grandes temas: la Medicina Personalizada contra el cáncer, los nanomedicamentos en la terapia del cáncer y las terapias basadas en la inmunomodulación.
This document discusses various treatment options for bronchial asthma and COPD, including short-acting beta agonists, long-acting beta agonists, inhaled corticosteroids, anticholinergics, antileukotrienes, IGE antagonists, PDE inhibitors, and anti-inflammatory drugs. It also discusses smoking cessation options like varenicline, nicotine vaccines, and rimonabant. New long-acting bronchodilators discussed include indacaterol, aclidinium bromide, and NVA237. Combination therapies involving inhaled corticosteroids and long-acting beta agonists are also summarized.
Analysis of Phenolic Antioxidants in Edible Oil/Shortening Using the PerkinEl...PerkinElmer, Inc.
Phenolic antioxidants are commonly used in food to prevent the oxidation of oils. Oxidized oil and fats cause foul odor and rancidity in food products, which is a major cause for concern to the food industry. Globally, regulations vary, but current maximum allowable levels are as low as 100 μg/g (100 ppm). This application note presents a UHPLC method for the analysis of the ten most common phenolic antioxidants that may be found in such products.
The document summarizes an experiment that exposed mice susceptible to atherosclerosis to different components of ultrafine particles (UFP) to evaluate their effects on oxidative stress. Mice were exposed to either the semi-volatile or non-volatile fraction of UFP for 8 weeks. Biomarkers of oxidative stress (glutathione, malondialdehyde, protein carbonyl) were measured in mice serum to determine if one fraction induced more stress. Results suggested the semi-volatile fraction containing polycyclic aromatic hydrocarbons caused higher lipid peroxidation, supporting the hypothesis that these components influence oxidative stress more than non-volatile ones.
Formulation and Evaluation of Sublingual Tablet of Enalapril Maleate By 32 Fu...PRASANTAKUMARMOHAPAT3
The aim of this work was to formulate and evaluate sublingual tablets of Enalapril maleate for
rapid management of Hypertension. In the present work, the metallic taste of Enalapril maleate
was masked by using Kyron T-114 in 1:2 ratio. The Drug-Resin Complex was formulated as
sublingual tablets using Cross Povidone (X1) and Avicel PH102 (X2) by direct compression
method. The sublingual tablets were evaluated such as thickness, hardness, % Friability, Wetting
time, disintegration time, Water absorption ratio and % CDR. In this study, the fast release of
tablets depends on the concentration of Cross Povidone (X1) and Avicel PH102 (X2). The
selected formulation showed the fastest release of the tablets in 45 s. Stability study was
performed by taking an optimized formulation and it was observed stable. The sublingual tablets
showed acceptable results in all studies. The results indicate that the formulation can be used for
rapid management of Hypertension. Also, Enalapril maleate’s bioavailability may be increased
by selecting sublingual route of administration.
Fescue toxicosis affects horses that graze on endophyte-infected tall fescue grass. The endophyte produces ergovaline, a toxin that disrupts hormone levels and can cause agalactia in pregnant mares. Studies examined mares treated with bromocriptine to mimic ergovaline's effects, finding decreased prolactin and progesterone levels. Mares treated with the D2 receptor antagonist domperidone saw increased prolactin and progesterone, showing it effectively treats fescue toxicosis. However, an agalactic mare from Japan had very low prolactin but normal progesterone, indicating its condition differs from typical fescue toxicosis and may not respond to domper
This study examined the effects of di-(2-ethylhexyl) phthalate (DEHP) exposure on the uterus of adult female rats. Rats were orally administered DEHP at doses of 0, 1, 10, and 100 mg/kg body weight daily for 30 days. Key findings include:
1) Serum estradiol levels were unchanged in the 1 and 10 mg groups but marginally increased in the 100 mg group. Progesterone levels increased in the 1 and 10 mg groups.
2) Histological examination found structural abnormalities in the uterus such as decreased diameter and thinning of layers in the 10 and 100 mg groups.
3) mRNA expression of estrogen receptor alpha decreased in the 100 mg
This randomized clinical trial compared two treatment regimens of natural surfactant preparations, Curosurf and Survanta, in 75 neonates with respiratory distress syndrome (RDS). Infants receiving Curosurf had a more rapid improvement in oxygenation and required lower ventilatory support up to 24 hours after treatment compared to those receiving Survanta. Complication rates including pneumothorax and severe intracranial hemorrhage were lower in the Curosurf group, though differences were not statistically significant. The Curosurf treatment regimen resulted in faster clinical improvement for RDS.
The document discusses food additives, including their consumption levels, categories, safety assessment process, and regulation. It notes that the average consumption of all food additives is 139 lbs per person per year in the US, but excludes common additives like spices and sugars. Safety assessment involves testing for toxicity and carcinogenicity in animals to determine an acceptable daily intake level for humans. Stringent regulations and approval processes exist in the US, EU, and other bodies to ensure food additives are safe for human use.
The document discusses parenteral preparations, which are sterile preparations intended for administration by injection, infusion, or implantation. They contain one or more active ingredients and are packaged in single-dose or multidose containers. The document outlines various aspects of parenteral preparations, including definitions, routes of administration, formulation components, evaluation tests, and sterilization methods.
The Differential Effect of Nembutal and Ketamine/Xylazine Anesthetic on QT In...CorDynamics
Nembutal and ketamine/xylazine were compared as anesthetics for guinea pigs tested with the QT-prolonging drug dofetilide. Dofetilide significantly increased the QTc interval in both anesthetic groups compared to controls. However, with Nembutal anesthesia, the QTc increased 22% at the highest dofetilide dose, versus 12% with ketamine/xylazine. No changes were seen in other ECG intervals or hemodynamics. Nembutal anesthetized guinea pigs were more sensitive to QT effects, making it the preferred choice for screening drugs' potential to prolong the QT interval.
This document summarizes the development and evaluation of a dry powder inhaler formulation. It first defines asthma and common asthma therapies. It then discusses various dry powder inhaler device types and their advantages. The document outlines the characterization of active pharmaceutical ingredients and lactose carrier particles. It details the formulation of different batches varying lactose carrier grade. The batches were evaluated for various properties and fine particle fraction. The optimized batch with highest fine particle fraction was subjected to 3-month stability studies under specified conditions.
Presentation at the ESPP stakeholder meeting concerning the use on farmland of sewage biosolids (04/12/2018) organised by the European Sustainable Phosphorus Platform (ESPP, www.phosphorusplatform.eu)
All outcomes of the meeting can be found here https://www.phosphorusplatform.eu/activities/conference/meeting-archive/1788-espp-meeting-sludge-2018
This document provides information on dipropylene glycol methyl ether (DPGME), including its identification, production, uses, environmental exposure and fate. DPGME is a mixture of four isomers used as a solvent in various industrial and commercial products. Its annual production in the US was estimated at 35 million pounds in 2000, with major uses in paints/coatings/inks and cleaners. DPGME is miscible with water, has low volatility, and is readily biodegradable. It is expected to partition primarily to water in the environment.
Analysis of Organophosphate Pesticides Residue on Crops in Abakaliki, Ebonyi ...IOSR Journals
This document analyzes organophosphate pesticide residue found on pumpkin crops in Abakaliki, Ebonyi State, Nigeria. Samples of pumpkin leaves were collected 3 days after being sprayed with organophosphate pesticides and analyzed using gas chromatography. Sample A contained dioxabenzeofos and phenanthrene. Sample B contained chlorethoxyfos, oxydeprofos, sulfotep, phenanthrene, and dioxabenzofos. Sample C contained chlonethoxy fos, oxydeprofos, sulfotep, phenanthrene, and dioxabenzofos. All residues were below the LD50 toxicity range for organophosphates. The
The document discusses Eribis Pharmaceuticals AB, a biotech company developing a novel cardioprotective drug called EP94 for the treatment of acute myocardial infarction (AMI). EP94 is a tetrapeptide that has shown cardioprotective effects in preclinical animal studies by reducing infarct size in a dose-dependent manner. The proposed mechanism of action involves opioid receptors, KATP channels and iNOS. Further preclinical studies are evaluating the dose response and exploring the involvement of these molecular pathways. The company is seeking funding to advance EP94 into clinical trials for AMI, which represents a large unmet medical need with millions of cases annually worldwide.
Get it Here - Cruelty Free Cosmetics - Resources for Healthy Children www.scribd.com/doc/254613619 ~ choosecrueltyfree.org.au - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
The five articles summarize and compare different tests for detecting bacterial endotoxins, including the rabbit pyrogen test and Limulus Amebocyte Lysate (LAL) test. The rabbit pyrogen test involves injecting a sample into rabbits and monitoring their temperatures, but it has limitations for certain vaccines. The LAL test detects endotoxins in vitro and is more sensitive than the rabbit test. Newer tests involving human cell lines are being developed as alternatives to better predict human responses to pyrogens.
The document summarizes a study that compared the efficacy of adding formoterol or salbutamol to regular ipratropium bromide treatment in COPD patients. The study found that:
1) Treatment with a combination of formoterol and ipratropium was more effective than a combination of salbutamol and ipratropium based on improvements in morning peak expiratory flow, lung function as measured by FEV1, and symptom scores.
2) Safety profiles were comparable between the two treatment combinations.
3) For COPD patients requiring combination bronchodilator treatment, adding formoterol to regular ipratropium treatment provided better clinical benefits than adding
The Analysis of SunscreenActive Ingredients and Parabens in Lotions and Lip B...PerkinElmer, Inc.
Individuals typically use 5-20 cosmetics per day, many of which contain sunscreen to prevent skin damage from the sun’s radiation, and antimicrobial preservatives called parabens. Although sunscreen-active ingredients are designed to block UV radiation, some cell damage may be caused when these ingredients are illuminated by sunlight after absorption into the skin. For example, oxybenzone, an ingredient considered safe by the FDA (Food and Drug Administration), is believed to contribute to the recent rise in melanoma cases by increasing the production of DNA-attacking free radicals upon UV exposure. Additionally, studies have shown oxybenzone to behave similarly to the hormone estrogen, suggesting that it may also contribute to the development of breast cancer. Parabens are absorbed through the skin via cosmetic applications and can be found in nearly all adult urine samples, with the highest concentrations observed in adult females and adolescents. Furthermore, parabens are thought to have estrogenic activity, which affects the expression of genes regulated by the natural form of estrogen, leading to early puberty in girls and an increased risk for the development of breast cancer.
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Analysis of Phenolic Antioxidants in Edible Oil/Shortening Using the PerkinEl...PerkinElmer, Inc.
Phenolic antioxidants are commonly used in food to prevent the oxidation of oils. Oxidized oil and fats cause foul odor and rancidity in food products, which is a major cause for concern to the food industry. Globally, regulations vary, but current maximum allowable levels are as low as 100 μg/g (100 ppm). This application note presents a UHPLC method for the analysis of the ten most common phenolic antioxidants that may be found in such products.
The document summarizes an experiment that exposed mice susceptible to atherosclerosis to different components of ultrafine particles (UFP) to evaluate their effects on oxidative stress. Mice were exposed to either the semi-volatile or non-volatile fraction of UFP for 8 weeks. Biomarkers of oxidative stress (glutathione, malondialdehyde, protein carbonyl) were measured in mice serum to determine if one fraction induced more stress. Results suggested the semi-volatile fraction containing polycyclic aromatic hydrocarbons caused higher lipid peroxidation, supporting the hypothesis that these components influence oxidative stress more than non-volatile ones.
Formulation and Evaluation of Sublingual Tablet of Enalapril Maleate By 32 Fu...PRASANTAKUMARMOHAPAT3
The aim of this work was to formulate and evaluate sublingual tablets of Enalapril maleate for
rapid management of Hypertension. In the present work, the metallic taste of Enalapril maleate
was masked by using Kyron T-114 in 1:2 ratio. The Drug-Resin Complex was formulated as
sublingual tablets using Cross Povidone (X1) and Avicel PH102 (X2) by direct compression
method. The sublingual tablets were evaluated such as thickness, hardness, % Friability, Wetting
time, disintegration time, Water absorption ratio and % CDR. In this study, the fast release of
tablets depends on the concentration of Cross Povidone (X1) and Avicel PH102 (X2). The
selected formulation showed the fastest release of the tablets in 45 s. Stability study was
performed by taking an optimized formulation and it was observed stable. The sublingual tablets
showed acceptable results in all studies. The results indicate that the formulation can be used for
rapid management of Hypertension. Also, Enalapril maleate’s bioavailability may be increased
by selecting sublingual route of administration.
Fescue toxicosis affects horses that graze on endophyte-infected tall fescue grass. The endophyte produces ergovaline, a toxin that disrupts hormone levels and can cause agalactia in pregnant mares. Studies examined mares treated with bromocriptine to mimic ergovaline's effects, finding decreased prolactin and progesterone levels. Mares treated with the D2 receptor antagonist domperidone saw increased prolactin and progesterone, showing it effectively treats fescue toxicosis. However, an agalactic mare from Japan had very low prolactin but normal progesterone, indicating its condition differs from typical fescue toxicosis and may not respond to domper
This study examined the effects of di-(2-ethylhexyl) phthalate (DEHP) exposure on the uterus of adult female rats. Rats were orally administered DEHP at doses of 0, 1, 10, and 100 mg/kg body weight daily for 30 days. Key findings include:
1) Serum estradiol levels were unchanged in the 1 and 10 mg groups but marginally increased in the 100 mg group. Progesterone levels increased in the 1 and 10 mg groups.
2) Histological examination found structural abnormalities in the uterus such as decreased diameter and thinning of layers in the 10 and 100 mg groups.
3) mRNA expression of estrogen receptor alpha decreased in the 100 mg
This randomized clinical trial compared two treatment regimens of natural surfactant preparations, Curosurf and Survanta, in 75 neonates with respiratory distress syndrome (RDS). Infants receiving Curosurf had a more rapid improvement in oxygenation and required lower ventilatory support up to 24 hours after treatment compared to those receiving Survanta. Complication rates including pneumothorax and severe intracranial hemorrhage were lower in the Curosurf group, though differences were not statistically significant. The Curosurf treatment regimen resulted in faster clinical improvement for RDS.
The document discusses food additives, including their consumption levels, categories, safety assessment process, and regulation. It notes that the average consumption of all food additives is 139 lbs per person per year in the US, but excludes common additives like spices and sugars. Safety assessment involves testing for toxicity and carcinogenicity in animals to determine an acceptable daily intake level for humans. Stringent regulations and approval processes exist in the US, EU, and other bodies to ensure food additives are safe for human use.
The document discusses parenteral preparations, which are sterile preparations intended for administration by injection, infusion, or implantation. They contain one or more active ingredients and are packaged in single-dose or multidose containers. The document outlines various aspects of parenteral preparations, including definitions, routes of administration, formulation components, evaluation tests, and sterilization methods.
The Differential Effect of Nembutal and Ketamine/Xylazine Anesthetic on QT In...CorDynamics
Nembutal and ketamine/xylazine were compared as anesthetics for guinea pigs tested with the QT-prolonging drug dofetilide. Dofetilide significantly increased the QTc interval in both anesthetic groups compared to controls. However, with Nembutal anesthesia, the QTc increased 22% at the highest dofetilide dose, versus 12% with ketamine/xylazine. No changes were seen in other ECG intervals or hemodynamics. Nembutal anesthetized guinea pigs were more sensitive to QT effects, making it the preferred choice for screening drugs' potential to prolong the QT interval.
This document summarizes the development and evaluation of a dry powder inhaler formulation. It first defines asthma and common asthma therapies. It then discusses various dry powder inhaler device types and their advantages. The document outlines the characterization of active pharmaceutical ingredients and lactose carrier particles. It details the formulation of different batches varying lactose carrier grade. The batches were evaluated for various properties and fine particle fraction. The optimized batch with highest fine particle fraction was subjected to 3-month stability studies under specified conditions.
Presentation at the ESPP stakeholder meeting concerning the use on farmland of sewage biosolids (04/12/2018) organised by the European Sustainable Phosphorus Platform (ESPP, www.phosphorusplatform.eu)
All outcomes of the meeting can be found here https://www.phosphorusplatform.eu/activities/conference/meeting-archive/1788-espp-meeting-sludge-2018
This document provides information on dipropylene glycol methyl ether (DPGME), including its identification, production, uses, environmental exposure and fate. DPGME is a mixture of four isomers used as a solvent in various industrial and commercial products. Its annual production in the US was estimated at 35 million pounds in 2000, with major uses in paints/coatings/inks and cleaners. DPGME is miscible with water, has low volatility, and is readily biodegradable. It is expected to partition primarily to water in the environment.
Analysis of Organophosphate Pesticides Residue on Crops in Abakaliki, Ebonyi ...IOSR Journals
This document analyzes organophosphate pesticide residue found on pumpkin crops in Abakaliki, Ebonyi State, Nigeria. Samples of pumpkin leaves were collected 3 days after being sprayed with organophosphate pesticides and analyzed using gas chromatography. Sample A contained dioxabenzeofos and phenanthrene. Sample B contained chlorethoxyfos, oxydeprofos, sulfotep, phenanthrene, and dioxabenzofos. Sample C contained chlonethoxy fos, oxydeprofos, sulfotep, phenanthrene, and dioxabenzofos. All residues were below the LD50 toxicity range for organophosphates. The
The document discusses Eribis Pharmaceuticals AB, a biotech company developing a novel cardioprotective drug called EP94 for the treatment of acute myocardial infarction (AMI). EP94 is a tetrapeptide that has shown cardioprotective effects in preclinical animal studies by reducing infarct size in a dose-dependent manner. The proposed mechanism of action involves opioid receptors, KATP channels and iNOS. Further preclinical studies are evaluating the dose response and exploring the involvement of these molecular pathways. The company is seeking funding to advance EP94 into clinical trials for AMI, which represents a large unmet medical need with millions of cases annually worldwide.
Get it Here - Cruelty Free Cosmetics - Resources for Healthy Children www.scribd.com/doc/254613619 ~ choosecrueltyfree.org.au - For more information, Please see Organic Edible Schoolyards & Gardening with Children www.scribd.com/doc/254613963 - Gardening with Volcanic Rock Dust www.scribd.com/doc/254613846 - Double Food Production from your School Garden with Organic Tech www.scribd.com/doc/254613765 - Free School Gardening Art Posters www.scribd.com/doc/254613694 - Increase Food Production with Companion Planting in your School Garden www.scribd.com/doc/254609890 - Healthy Foods Dramatically Improves Student Academic Success www.scribd.com/doc/254613619 - City Chickens for your Organic School Garden www.scribd.com/doc/254613553 - Huerto Ecológico, Tecnologías Sostenibles, Agricultura Organica www.scribd.com/doc/254613494 - Simple Square Foot Gardening for Schools - Teacher Guide www.scribd.com/doc/254613410 - Free Organic Gardening Publications www.scribd.com/doc/254609890 ~
The five articles summarize and compare different tests for detecting bacterial endotoxins, including the rabbit pyrogen test and Limulus Amebocyte Lysate (LAL) test. The rabbit pyrogen test involves injecting a sample into rabbits and monitoring their temperatures, but it has limitations for certain vaccines. The LAL test detects endotoxins in vitro and is more sensitive than the rabbit test. Newer tests involving human cell lines are being developed as alternatives to better predict human responses to pyrogens.
The document summarizes a study that compared the efficacy of adding formoterol or salbutamol to regular ipratropium bromide treatment in COPD patients. The study found that:
1) Treatment with a combination of formoterol and ipratropium was more effective than a combination of salbutamol and ipratropium based on improvements in morning peak expiratory flow, lung function as measured by FEV1, and symptom scores.
2) Safety profiles were comparable between the two treatment combinations.
3) For COPD patients requiring combination bronchodilator treatment, adding formoterol to regular ipratropium treatment provided better clinical benefits than adding
The Analysis of SunscreenActive Ingredients and Parabens in Lotions and Lip B...PerkinElmer, Inc.
Individuals typically use 5-20 cosmetics per day, many of which contain sunscreen to prevent skin damage from the sun’s radiation, and antimicrobial preservatives called parabens. Although sunscreen-active ingredients are designed to block UV radiation, some cell damage may be caused when these ingredients are illuminated by sunlight after absorption into the skin. For example, oxybenzone, an ingredient considered safe by the FDA (Food and Drug Administration), is believed to contribute to the recent rise in melanoma cases by increasing the production of DNA-attacking free radicals upon UV exposure. Additionally, studies have shown oxybenzone to behave similarly to the hormone estrogen, suggesting that it may also contribute to the development of breast cancer. Parabens are absorbed through the skin via cosmetic applications and can be found in nearly all adult urine samples, with the highest concentrations observed in adult females and adolescents. Furthermore, parabens are thought to have estrogenic activity, which affects the expression of genes regulated by the natural form of estrogen, leading to early puberty in girls and an increased risk for the development of breast cancer.
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
Are you looking for a long-lasting solution to your missing tooth?
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Debunking Nutrition Myths: Separating Fact from Fiction"AlexandraDiaz101
In a world overflowing with diet trends and conflicting nutrition advice, it’s easy to get lost in misinformation. This article cuts through the noise to debunk common nutrition myths that may be sabotaging your health goals. From the truth about carbohydrates and fats to the real effects of sugar and artificial sweeteners, we break down what science actually says. Equip yourself with knowledge to make informed decisions about your diet, and learn how to navigate the complexities of modern nutrition with confidence. Say goodbye to food confusion and hello to a healthier you!
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
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The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
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Spontaneous Bacterial Peritonitis - Pathogenesis , Clinical Features & Manage...Jim Jacob Roy
In this presentation , SBP ( spontaneous bacterial peritonitis ) , which is a common complication in patients with cirrhosis and ascites is described in detail.
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STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
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geriatric patients (e.g., hypertension).
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
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Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Medical Quiz ( Online Quiz for API Meet 2024 ).pdf
LAL_Vol.13No.2.pdf
1. In this issue:
Endotoxin Limits
Technical Services Department
Calendar
Volume 13, No.2
pfiJLAL
UPDATE®
June 1995
Dear LAL User,
There are now definite signs that summer will soon arrive on
Cape Cod. The horseshoe crabs have appeared once again in the
shallow bays in preparation for spawning and our laboratory is
bursting with activity. Although the amount ofour harvestfrom
season to season is difficult to predict, the last two years have seen
recordyields ofLAL and we hope for a repeat this year. Even with
increased sales, these good harvests have resulted in an excellent
inventory ofPyrotell'" (all sensitivities), Pyrotell'"-T, and
Pyrochrome"
For our European customers, the changeoverfrom afragmented
distribution system to direct supply and service from Associates of
Cape Cod International, Inc. is complete. Our two European offices
are located in Walldorf(near Frankfurt) Germany, and Liverpool,
England. Our general managers, Dr. Peter Weidner (ACCI-Europe
in Germany), and Tony Coyle (ACCI-UK) have extensive experience
with all aspects ofLAL and endotoxin testing. In addition to our
expanded technical services, ACCI-Europe can provide multilingual
help for our clients in France, Italy, and Spain.
The Tyros™ for Windows" software for the LAL-5000 is now
firmly established in the marketplace. Ifyou are using the LAL-5000
and have not yet switched to Tyros™, I strongly urge you to
consider doing so. It is much easier andfaster to use and has a host
ofadvancedfeatures.
As you can see, it is not all vacation and retirement on Cape Cod.
Even so, please feel free to make our summer even busier! Our
technical service team, Laurie, Keith, and Carmen are ready to
answer your technical questions, as are other personnel, including
Drs. Dawson and Gould, and ofcourse, myself.
Sincerely,
Thomas 1. Novitsky, Ph.D.
President/CEO
o 1995, Associates of Cape Cod, Inc., Woods Hole, Massachusetts
Endotoxin
Limits
Michael E. Dawson, Ph.D.
It has been established that the
pyrogenic threshold for humans is
approximately five endotoxin units
(EU) per kilogram body weight (1,2).
This means that administration of
endotoxin concentrations of 5 EUlkg
or greater can be expected to elicit a
pyrogenic response. Consequently,
an endotoxin limit of 5 EUlkglhr has
been set for most injectable
(parenteral) products. An injectable
product for which this limit applies
cannot be sold if the endotoxin
concentration is such that a recipient
of the maximum dose would receive
this amount of endotoxin or more.
The endotoxin limit is represented
by the term K. The value of K is 5
EUlkglhr for injectables, other than
those administered intrathecally. For
these, the endotoxin limit is more
stringent and K= 0.2 EUlkglhr.
Given that the average human
weighs 70 kg, the maximum amount
ofendotoxin that can be received by a
patient being given a non-intrathecal
product should not exceed 350 EU
per hour (70 x 5 EUlkglhr).
However, the limit does not
account for a patient being given
several drugs and/or solutions at
All rights reserved
2. once, which is a common occurrence.
Fortunately, most drug products and
solutions contain considerably less
endotoxin than the allowable limit.
Many manufacturers set specifica-
tions that are tighter than the required
limit.
The calculation of endotoxin
limits for injectable drugs adminis-
tered per square meter is based on the
assumption that a typical adult has a
surface area of 1.8 square meters.
For drugs with a dose expressed per
kg, the whole body limit is 350 ED.
Thus, the endotoxin limit per square
meter is 350 EU/1.8 m2
= 194EU/m2
This is an absolute and is equivalent
to a value of 5 EU/kg for K for
products administered per kg. To
calculate the endotoxin limit of a
product with a dose expressed per
square meter, divide 194 EU/ m? by
the dose to give an endotoxin limit per
unit of product.
Endotoxin limits for radio-
pharmaceuticals are addressed in a
footnote at the end of Appendix E to
the FDA Guideline on the LAL Test
(3). For these productsK= 175 (EU)/
V (or 14(EU)N for intrathecals),
where V is the maximum (whole
body) dose in ml at expiration of the
product. The units (the EU given in
parentheses) are not specified in the
Guideline but must be included if the
units are to be expressed in EU/m!.
The USP limit for large volume
parenterals (LVPs) is 0.5 EU/ml and
is derived from a rabbit dose of10 ml/
kg for Pyrogen tests. A typical LVP
administered at 700 ml/hr also gives a
limit of 0.5 EU/m!. The USP
endotoxin limit for WFI and SWFI is
0.25 EU/m!. For medical devices,
the USP limit is 20 EU/device, and
2.15 EU/device for devices that
contact the cerebrospinal fluid. The
endotoxin limits for devices were
discussed in the September 1994
LAL UPDATE Vol. 13, Number 2, page 2
issue of the LAL UPDATE®
Generally, the aim of testing is to
insure that the sample under test
could not deliver more than 5 (or 0.2)
EU/kg/hr of endotoxin to a patient.
Thus, the endotoxin limit for a
specific product depends on the
maximum dose of product that a
patient might receive. The smaller
the dose of the product per kg, the
higher the endotoxin limit per unit
dose ofthe product.
This discussion of limits only
applies to release testing of finished
products. However, endotoxin limits
may be set for raw materials and in-
process samples.
Determining the Endotoxin Limit
ofa Product
The first step is to look up the
product in the FDA Guideline to see
if an endotoxin limit is listed in the
Appendix E. (The most recent
revision to Appendix E at this time is
dated July, 1994). If the product is
listed, check that the maximum dose
of the product is correct for your
product. If the dose is greater than
that given in the table, calculate the
limit as described below. It is a good
idea to calculate the limitas described
below anyway. There have been
mistakes in the Appendix in the past.
The 1987 Guideline states that the
dose used should be the rabbit dose
(as used in the USP Pyrogen Test) or
the maximum human dose, which-
ever is greater. Since 1987, the USP
has used only human doses to
calculate endotoxin limits and the
FDA has incorporated this into their
more recent revisions ofAppendix E.
The term M is used for the maximum
dose.
When calculating the limit for
drug products, if the dose is
expressed for whole (adult) body,
first divide it by 70 kg to give the dose
per kg. Then divide K (5 EU/kg, 0.2
EU/kg, 194 EU/m2
or 175 EU) by M
(or V) to give the endotoxin limit per
unit weight/volumelinternational
unit, etc.
Examples:
Calculation of the endotoxin limit
for a non-intrathecal, injectable
drug product:
Product A has a maximum human
(whole body) dose of 1.0 g
Dose per kg =
.Ls, = 0.0143 g/kg = 14.3 mg/kg
70 kg
Endotoxin limit =
K = 5 ED/kg = 0.35 ED/mg
M 14.3 mg/kg
Use the concentration of the product
(potency in final product) to convert
the endotoxin limit into EU/m!.
Thus, using the example above, if
the concentration of product in the
(presentation) container is 100 mg/
ml, or if bulk product is dissolved to
give 100 mg/m!:
Endotoxin limit =
0.35 EU/mg x 100 mg/ml = 35 ED/ml
Convert the limit to EU/ml
because these are the units of the
endotoxin standards in the LAL test
(as well as the limits for the sensitivity
of an LAL gel-clot reagent). This
gives an endotoxin limit for the
product so that it can be determined
whether the product passes or fails at
that limit. It is important to note that
the limit in EU/ml only applies to the
stated concentration ofproduct. Ifthe
concentration changes, the limit
changes.
The limits calculated above are
the maximum allowed. It may be
decided that tighter limits are
3. From left to right: Laurie Fife, Keith Richardson and Carmen Barillas
Meet Associates of Cape Cod, Inc.'s
Technical Services Department
desirable. Usually the limit is greater
than the sensitivity ofthe test method.
If the gel-clot method is used as a
pass/fail test, the product must be
diluted.
Calculation of the endotoxin limit
for a product with a dose
expressed per square meter:
For a product with a dose of I g/m?
and a potency of 50 mg/ml:
Endotoxin Limit =
194 ED/ m?= 194 ED/g = 0.194 ED/mg
1 g/m?
0.194 ED/mg x 50 mg/ml = 9.7 El.l/rnl
Calculation of an endotoxin limit
for a radio-pharmaceutical
product:
For a product with a (whole body)
dose at expiration of 7 ml:
Endotoxin Limit =
K 175 ED 25 ED/ml
V 7ml
Conclusion
A clear understanding of endotoxin
limits and how they are derived is of
critical importance to the release of
product by any LAL test method.
References:
1. EIin, R. J., S. M. Wolff, K. P. W. J. McAdam, L.
Chedid, and F. Oberling. 1981. Properties of
reference Escherichia coli endotoxin and its
phthalylated derivative in humans. J. Infect. Dis. 144:
329-336.
2. Hochstein, H. D., E. A. Fitzgerald, F. G.
McMachon, and R. Vargas. 1994. Properties of US
Standard Endotoxin (EC-5) inhuman male volunteers.
Journal of Endotoxin Research. 1:52-56.
3. Guideline on Validation of the Limulus
Amebocyte Test as an End-product Endotoxin
Test for Human and Animal Parenteral Drugs,
Biological Products, and Medical Devices. U.S.
Department of Health and Human Services, Public
Health Services, Food and Drug Administration,
December 1987.
LAL UPDATE Vol. 13, Number 2, page 3
With the continuing expansion ofour
business, we now have three Technical
Services Representatives to answer your
LAL-related questions. As in the past,
all calls are answered immediately by
our Technical Services Department. The
department includes: Laurie Fife, Se-
nior Technical Services Specialist,
Keith Richardson, Technical Analyst
and Carmen Barillas, Technical Ser-
vice Representative.
Laurie joined ACC in 1993 after
doing research for six years in the areas
ofcell/molecularbiology and biochemis-
try. For two years before moving to Cape
Cod, Laurie was a Scientific Liaison at
Organogenesis, Inc.
At ACC, Laurie provides technical
assistance and participates in the training
courses. She specializes in the chro-
mogenic LAL method. She has a BS
degree in Animal Science from the
University of Vermont.
Keith has been an employee of
Associates of Cape Cod, Inc. for more
than five years and has experience in
many facets of LAL technology, from
hemolymph collection to use of our final
products. He is responsible for all
aspects ofturbidimetric LAL testing, and
is the technical support person for the
LAL-5000 and Pyros™ software. As
our turbidimetric specialist, Keith par-
ticipates in ACC training courses. Keith
has a BS degree in Biology and Marine
Sciences from Southeastern Massachu-
setts University.
Carmen has an MS in Biology from
Worcester Polytechnic Institute and did
her thesis work in the Biochemistry
Department at the University of Massa-
chusetts Medical Center. She was Senior
Research Associate at Genica Pharma-
ceuticals Corporation, where she did
product development and research in
molecular biology for two years before
joining ACC in 1994. Carmen is a native
of Guatemala, Central America, and is
fluent in both Spanish and English. The
combination ofher technical background
and language skills makes Carmen a
welcome addition to our technical
department. She also participates in the
training courses offered by ACe.
For expert technical help, regardless of
the brand of LAL Limulus Amebocyte
Lysate you use, call 800-848-3248.