This article examines the cultural drivers behind the illegal wildlife trade of slender and slow lorises in South and Southeast Asia using an ethnoprimatological approach. The authors conducted fieldwork including participant observation and interviews to understand the origins and uses of lorises being sold in markets. They found the trade is driven by the use of lorises in traditional medicine due to lack of access to modern healthcare. The deep-rooted cultural beliefs around lorises are inhibiting conservation efforts. The comprehensive study combined ethnographic accounts with trade data to provide insights into the ultimate causes of the trade from the local perspective.