Kim Solez, MD
Who Am I?
Who Am I?
 1991 First Conference
 1993 First Kidney International publication
 1995 Integration with CADI
 1997 Integration with...
Significance of ‘Banff papers’
• 4244 citations of the 9 Banff meeting reports
• 790 Banff / Transplantation papers in Pub...
Organizational structure of the Banff Foundation For Allograft Pathology
Board of Trustees:
K. Solez (Chair), L. Racusen, ...
Target Audience for the 2015 joint
CST/Banff meeting: total ~600 expected
delegates
 Basic Scientists
 Pathologists
 Im...
The Banff Process
Consensus communication in renal transplantation
a
The Banff
lesions
g, i, t, v - score
The Banff
commun...
The Banff Schema was first developed
at a meeting of pathologists, clinicians
and surgeons in Banff, Alberta, Canada,
Augu...
The Banff Schema was first developed
at a meeting of pathologists, clinicians
and surgeons in Banff, Alberta, Canada,
Augu...
Moore’s Law&Eroom’s Law , the
technological Singularity and
exponential change, exponential
decline in # new drugs per
bi...
The Banff Foundation for Allograft Pathology
Must Remain Youthful and Relevant for the
Future – Must Adapt, Plan for Chang...
The spectacular dynamics influencing the
pace of stem generation of organs replacing
transplantation in the future.
 Ther...
The Technological
Singularity
 Transplant
pathologists will also
become tissue
engineering
pathologists,
pathologists who
analyse organs grown
from ste...
Turtles
All
the
Way
Down
abstrusegoose.com/155
Animal
Analogies
Limited.
Need Human
Alter Egos
CCM-L
Characters
Off-Topic
Discussions
NEPHROL
No Characters
No Off-Topic
Discussions
Many Military
Awards, Karate
Black Belt
No Civilian Awards
Never Served in
Military
Many Civilian
Awards
Rock Band
Motorcycles
Colorful History in
60’s and 70’s
No Band or
Motorcycle
Boring Young Person
Crippen A
Myth?
Proves the
Metaphor
Works!
Solez Global Clinical Trial Committee Presentation Stem Cells and Future of Transplantation
Solez Global Clinical Trial Committee Presentation Stem Cells and Future of Transplantation
Solez Global Clinical Trial Committee Presentation Stem Cells and Future of Transplantation
Solez Global Clinical Trial Committee Presentation Stem Cells and Future of Transplantation
Solez Global Clinical Trial Committee Presentation Stem Cells and Future of Transplantation
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Solez Global Clinical Trial Committee Presentation Stem Cells and Future of Transplantation

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Dr. Kim Solez Global Clinical Trial Committee Presentation "Stem Cells and the Future of Transplantation"August 5, 2014.

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Solez Global Clinical Trial Committee Presentation Stem Cells and Future of Transplantation

  1. 1. Kim Solez, MD
  2. 2. Who Am I?
  3. 3. Who Am I?
  4. 4.  1991 First Conference  1993 First Kidney International publication  1995 Integration with CADI  1997 Integration with CCTT classification  1999 Second KI paper. Clinical practice guidelines. Implantation biopsies.  2001 Classification of antibody-mediated rejection: Regulatory agencies participating  2003 Genomics focus, ptc cell accumulation scoring  2005 Gene chip analysis. Elimination of CAN, identification of chronic antibody-mediated rejection.  2007 First meeting far from a town called “Banff” – La Coruna, Spain.  2009 Working groups. Meeting in Banff, Alberta, Canada  2013 Establishment of Banff Foundation for Allograft Pathology
  5. 5. Significance of ‘Banff papers’ • 4244 citations of the 9 Banff meeting reports • 790 Banff / Transplantation papers in PubMed • Banff 2003 meeting report (ABMR criteria) = most cited AJT paper • 3 Banff meeting reports are among the top 4 cited AJT articles
  6. 6. Organizational structure of the Banff Foundation For Allograft Pathology Board of Trustees: K. Solez (Chair), L. Racusen, D. Glotz, J. Demetris, M. Mengel, M. Mihatsch, D. Seron, N. Schmidt 2015 Local Conference chair: Michael Mengel Organ Steering committee Chairs: Composite tissues: Linda Cendales Heart : Rene Rodriguez Kidney: Mark Haas Liver: Jake Demetris Lung: William Wallace and Carol Farver Pancreas: Cinthia Drachenberg Banff Working Group (BWG) Leads: Molecular transplantation pathology: Michael Mengel, Banu Sis Isolated v-lesions: Banu Sis, Ed Kraus Quality assurance in transplantation diagnostics: Michael Mengel and Parmjeet Randhawa C4d-negative ABMR: Mark Haas, Banu Sis, Alexandre Loupy Fibrosis scoring: Robert Colvin, Brad Farris, Michael Mengel Digital Pathology in Transplantation: Jake Demetris 2015 Scientific program committee: Alex Loupy (Chair) Mark Haas, Banu Sis, Kathryn Tinkham, Candice Rofousse, Chris Bellamy, Lynn Cornell, Carmen LeFaucheur Composite tissues: Linda Cendales Heart : Rene Rodriguez Liver: Jake Demetris Lung: William Wallace and Carol Farver Pancreas/Islets: Cinthia Drachenberg and John Papadimitriou Secretary/Treasurer: Michael Mengel funding collaboration reports to reports to collaboration collaboration reports to collaboration progress reports to Budged proposal and accountability for meeting costs support
  7. 7. Target Audience for the 2015 joint CST/Banff meeting: total ~600 expected delegates  Basic Scientists  Pathologists  Immunogeneticists and HLA experts  Transplant Physicians: Internal Medicine, Surgery, Infectious Diseases, Critical Care  Allied Health Care  Students, Trainees, Fellows
  8. 8. The Banff Process Consensus communication in renal transplantation a The Banff lesions g, i, t, v - score The Banff community Pathologists Nephrologists Tx-Surgeons Lab-Medicine established by consensus in 1991 The Banff classification Current consensus for diagnostics moderated Banff meetings thesis-antithesis-synthesis tentative thresholds participate refinementBanff Working Groups Feedback concerning weaknesses and strengths by results from independent research New members Biostaticians Molecular Biologists “Omics”-specialists Off-springs Liver Pancreas Lung, Heart CTA
  9. 9. The Banff Schema was first developed at a meeting of pathologists, clinicians and surgeons in Banff, Alberta, Canada, August 2-4, 1991 and has become the worldwide standard for the interpretation of transplant biopsies.
  10. 10. The Banff Schema was first developed at a meeting of pathologists, clinicians and surgeons in Banff, Alberta, Canada, August 2-4, 1991 and has become the worldwide standard for the interpretation of transplant biopsies.
  11. 11. Moore’s Law&Eroom’s Law , the technological Singularity and exponential change, exponential decline in # new drugs per billion dollars R&D expenditure.
  12. 12. The Banff Foundation for Allograft Pathology Must Remain Youthful and Relevant for the Future – Must Adapt, Plan for Changes  As the field changes and stem-cell-grown organs replace transplantation, the organization must change with it  Transplantation may be loosing its luster but luster of the Banff Foundation for Allograft Pathology can remain strong.  As an exercise in alternative realities I asked participants to consider the very different life of David Crippen, my counterpart in critical care medicine. We need to consider changes that large!
  13. 13. The spectacular dynamics influencing the pace of stem generation of organs replacing transplantation in the future.  There were YouTube videos (now removed) suggesting that stem cell generation of complex organs in humans would be routine by 2020. Problems of clotting, endothelial loss, and cell type selection errors not mentioned.  The dramatic slowdown of new drug approvals (Eroom’s Law) by the FDA suggests that the FDA is ripe for disruptive innovation. Has happened.  However stem cell therapies may be the last area the FDA will relax regulation in, as unproven bogus stem cell therapies are causing widespread suffering and protection of the general public is needed.
  14. 14. The Technological Singularity
  15. 15.  Transplant pathologists will also become tissue engineering pathologists, pathologists who analyse organs grown from stem cells. This is not something beyond us, we can adapt to a work life that includes stem cells.. Someone needs to cross the disciplines,
  16. 16. Turtles All the Way Down abstrusegoose.com/155
  17. 17. Animal Analogies Limited. Need Human Alter Egos
  18. 18. CCM-L Characters Off-Topic Discussions NEPHROL No Characters No Off-Topic Discussions
  19. 19. Many Military Awards, Karate Black Belt No Civilian Awards Never Served in Military Many Civilian Awards
  20. 20. Rock Band Motorcycles Colorful History in 60’s and 70’s No Band or Motorcycle Boring Young Person
  21. 21. Crippen A Myth? Proves the Metaphor Works!

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