Kim Solez "Shedding New Light on Teachable Moments at Nephrology/Pathology Rounds" April 8, 2016, at the University of Alberta, in Edmonton, Alberta, Canada.
Kim Solez Renal transplant pathology and future perspectivesKim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives" as a TTS webinar on Dec. 8 at noon EST . Includes discussion of the new discipline of tissue engineering pathology. https://www.tts.org/education/advanced-renal-transplantation
Jack Tuszynski From Quantum Physics to Quantum Biology in 100 Years. How long...Kim Solez ,
Jack Tuszynski presents "From Quantum Physics to Quantum Biology in 100 Years. How long to Quantum Medicine?" March 17 and 22, 2016 University of Alberta, Edmonton, Canada.
Barcelona Banff 2017 Meeting InformationKim Solez ,
The 2017 BANFF - SCT Congress will be held from Monday March 27th to Friday March 31st in Barcelona, Spain. The venue will be Barcelona University, which is located in the city center and has good public transportation access. The university has modern facilities including the Paraninf Room that can seat 488 people for plenary sessions, the Aula Magna that can seat 184 people for parallel sessions, and the Ramón y Cajal Room that has seating for 44 people on two floors and is equipped with a screen and WiFi like the other rooms. Contact information is provided for the congress.
How to Make Awesome SlideShares: Tips & TricksSlideShare
Turbocharge your online presence with SlideShare. We provide the best tips and tricks for succeeding on SlideShare. Get ideas for what to upload, tips for designing your deck and more.
Este documento resume los principales usos y hallazgos de la biopsia renal en el trasplante de riñón. Explica que la biopsia es indispensable para determinar la causa de disfunción aguda y útil para evaluar el daño crónico y pronosticar la supervivencia del injerto. Describe los patrones histológicos del rechazo mediado por células T e inmunoglobulinas, así como cambios atribuibles a toxicidad por fármacos o enfermedades virales. Finalmente, enfatiza la necesidad de correlacionar los
Kim Solez - The Future of the Banff Meetings and Banff Foundation for Allogra...Kim Solez ,
Dr. Kim Solez's presentation of The Future of the Banff Meetings and Banff Foundation for Allograft Pathology given at the opening of the Twelve Banff Conference on Allograft Pathology on August 19, 2013, in Comandatuba-Bahia, Brazil. The video of this presentation is at http://youtu.be/Hctwcq7FHvE See http://cybernephrology.ualberta.ca/banff/2013
Kim Solez Renal transplant pathology and future perspectivesKim Solez ,
Dr. Kim Solez presents "Renal transplant pathology and future perspectives" as a TTS webinar on Dec. 8 at noon EST . Includes discussion of the new discipline of tissue engineering pathology. https://www.tts.org/education/advanced-renal-transplantation
Jack Tuszynski From Quantum Physics to Quantum Biology in 100 Years. How long...Kim Solez ,
Jack Tuszynski presents "From Quantum Physics to Quantum Biology in 100 Years. How long to Quantum Medicine?" March 17 and 22, 2016 University of Alberta, Edmonton, Canada.
Barcelona Banff 2017 Meeting InformationKim Solez ,
The 2017 BANFF - SCT Congress will be held from Monday March 27th to Friday March 31st in Barcelona, Spain. The venue will be Barcelona University, which is located in the city center and has good public transportation access. The university has modern facilities including the Paraninf Room that can seat 488 people for plenary sessions, the Aula Magna that can seat 184 people for parallel sessions, and the Ramón y Cajal Room that has seating for 44 people on two floors and is equipped with a screen and WiFi like the other rooms. Contact information is provided for the congress.
How to Make Awesome SlideShares: Tips & TricksSlideShare
Turbocharge your online presence with SlideShare. We provide the best tips and tricks for succeeding on SlideShare. Get ideas for what to upload, tips for designing your deck and more.
Este documento resume los principales usos y hallazgos de la biopsia renal en el trasplante de riñón. Explica que la biopsia es indispensable para determinar la causa de disfunción aguda y útil para evaluar el daño crónico y pronosticar la supervivencia del injerto. Describe los patrones histológicos del rechazo mediado por células T e inmunoglobulinas, así como cambios atribuibles a toxicidad por fármacos o enfermedades virales. Finalmente, enfatiza la necesidad de correlacionar los
Kim Solez - The Future of the Banff Meetings and Banff Foundation for Allogra...Kim Solez ,
Dr. Kim Solez's presentation of The Future of the Banff Meetings and Banff Foundation for Allograft Pathology given at the opening of the Twelve Banff Conference on Allograft Pathology on August 19, 2013, in Comandatuba-Bahia, Brazil. The video of this presentation is at http://youtu.be/Hctwcq7FHvE See http://cybernephrology.ualberta.ca/banff/2013
La insuficiencia renal aguda (IRA) se caracteriza por una disminución rápida de la función renal en horas o días. Puede ser pre-renal (60-70% de los casos), renal (20-30%) o posrenal (10%). La forma pre-renal ocurre cuando hay hipoperfusión renal y la estructura renal se mantiene normal. Los síntomas incluyen oliguria, aumento de productos nitrogenados en sangre y disminución de la diuresis. El tratamiento se enfoca en corregir la causa subyacente y mejorar el flujo s
Mark Haas Kidney Summary Banff 2013 in Brazil Kim Solez ,
Kidney summary from 12th Banff Conference on Transplant Pathology from the meeting in Comandatuba-Bahia, Brazil on August 23rd, 2013 http://cybernephrology.ualberta.ca/banff/2013
Este documento proporciona información sobre el virus BK (BKV), un poliomavirus humano. Describe que el BKV es la causa más común de nefropatía viral en receptores de trasplante renal. Explica que la primoinfección por BKV generalmente ocurre en la infancia y que el virus permanece latente en el riñón y las vías urinarias. Tras la inmunosupresión por un trasplante renal, el BKV puede reactivarse y causar nefropatía, lo que puede conducir a la pérdida
JerusalemL practical immuno for hepatobiliary neoplasiaNeil Theise
This document discusses immunohistochemistry markers that can be used to differentiate various hepatobiliary neoplasms and lesions. It begins with an overview of markers that can help distinguish benign from malignant hepatocytes, such as CD34 and reticulin staining. The document then covers marker panels useful for specific diagnoses, such as distinguishing hepatocellular carcinoma from metastatic tumors. Several case examples are presented to demonstrate the application of immunohistochemistry in accurately diagnosing difficult hepatobiliary cases.
Este documento describe la historia y las partes de dos tipos de microscopios electrónicos: el microscopio electrónico de transmisión (TEM) y el microscopio electrónico de barrido (SEM). El TEM emite un haz de electrones hacia el objeto para aumentarlo, mientras que el SEM barre la superficie de la muestra punto por punto con electrones de un cañón. Ambos microscopios pueden utilizarse para estudiar la morfología de una variedad de materiales a nivel microscópico y nanoscópico.
Methotrexate is an antifolate drug that inhibits dihydrofolate reductase (DHFR), blocking the production of nucleotides needed for DNA synthesis. It is used to treat cancers like acute lymphoblastic leukemia as well as autoimmune diseases like rheumatoid arthritis. Methotrexate is transported into cells and polyglutamated, increasing its intracellular activity and half-life. It causes cell death by inhibiting DNA synthesis and inducing strand breaks. Resistance can develop through reduced polyglutamation, increased DHFR levels, or drug efflux pumps. The cytotoxic effects of methotrexate are S-phase specific and depend on drug concentration and duration of exposure.
This white paper has elicited views from a broad group of
industry parDcipants about the future of the Biosciences
industry in Singapore. It provides themes that can help to
guide the development of innovaDve ideas to propel the next
lap of Biosciences growth in Singapore.
El documento compara los microscopios electrónico y de luz, explicando que el electrónico permite mayores aumentos y resolución al usar electrones en lugar de luz. Describe los componentes y usos del microscopio electrónico de transmisión y de barrido, incluyendo la formación de imágenes y señales generadas.
This article features an exclusive interview with an artist, including a quotation relating to the interview. It also includes a main image of the artist as well as smaller additional images of the artist.
O Espaço Peon Guimarães oferece treinamento individualizado em horários específicos nas segundas, terças e quartas nas piscinas grande e pequena, com opções entre 07:55, 14:55, 16:00 e 16:45.
El documento contiene varias noticias relacionadas con Oaxaca, México. Incluye una historia sobre la promesa incumplida del gobernador de crear una secretaría ambiental, otra sobre las anomalías encontradas por la Auditoría Superior de la Federación en el uso de fondos federales por el estado de Oaxaca, y una más sobre un paro de trabajadores del IMSS exigiendo mejoras salariales y medicamentos.
The document discusses the pros and cons of implementing electronic health records (EHRs) in hospitals and healthcare facilities. Some key benefits discussed include improved data accessibility, computerized physician order entry, improved charge capture, and opportunities for preventative health screenings. However, the document also notes several challenges, such as increased time spent on documentation, costs of setup and maintenance, decreased productivity during implementation, and issues with a lack of interoperability between different EHR systems. Overall, the document provides an overview of the debate around whether the benefits of EHRs outweigh the drawbacks.
3 ways fragmented clinical communication is compromising patient carePatientSafe Solutions
1. Patient care is delayed due to inefficient systems and workflows
2. Multi-device digital communication complicates critical context
3. Unmanaged use of personal smartphones jeopardizes PHI security
European Pharmaceutical Review: Trials and Errors in NeuroscienceKCR
This document discusses several challenges of conducting clinical research in neuroscience. It notes that while interest and publications in neuroscience have increased, the nervous system remains the least understood part of the human body. Conducting global clinical trials in neuroscience poses difficulties due to variations in where patients can be found, standards of care between countries, and restrictions on access to modern therapies. The document also outlines problems with using complex questionnaires in trials and inconsistencies in how patients perceive and report their symptoms.
The value of real-world evidence for clinicians and clinical researchers in t...Arete-Zoe, LLC
In the midst of a rapidly spreading global pandemic, real-world evidence can offer invaluable insight into the most promising treatments, risk factors, and not only predict but suggest how to improve outcomes. Despite overwhelming news coverage, significant knowledge gaps regarding COVID-19 persist. The current uncertainties regarding incidence and the case fatality rate can only be addressed by widespread testing. But the paucity of testing, and diversity of approaches implemented in different countries, particularly among the general asymptomatic public, perpetuates a lack of understanding about spread and infectivity. The essential indicators that would describe the pandemic more accurately can be obtained using real-world data (RWD). To that purpose, we designed a data collection tool to collect data from hospitals that treat COVID-19 patients. The captured data will enhance our understanding of the COVID-19 pandemic, identify risk factors relevant for triage, relate to other similar seasonal infections and gain insight into the safety and efficacy of experimental and off-label therapies. Knowledge derived from a focused data collection effort will enable clinicians to adjust rapidly clinical protocols and discontinue interventions that turn out to be ineffective or harmful. By deploying our elegantly designed survey to capture routine clinical indicators, we avoid placing an additional burden on practitioners. Systematically generating real-world evidence can decrease the time to insight compared to randomized clinical trials, improving the odds for patients in rapidly changing conditions.
This document discusses Symptom Management Theory (SMT), a nursing theory that explains the interaction between a patient's symptom experience, symptom management strategies, and outcomes. The theory has potential to improve chronic disease management using telemonitoring. Telemonitoring allows remote monitoring of patient symptoms and communication with providers, which could guide self-management according to SMT's conceptual domains of symptom experience, recommended strategies, and evaluation of outcomes. The document reviews SMT and proposes it as a framework to inform telemonitoring intervention design.
Symptom Management Theory (SMT) developed at UCSF explains the interaction between symptom experience, management strategies, and outcomes. The theory has potential to improve outcomes and lower costs of chronic disease management with telemonitoring by allowing remote communication between patients and providers about symptoms and management strategies. Modifications may be needed to account for the telemonitoring context and communication changes.
Symptom Management Theory (SMT) developed at UCSF explains the interaction between symptom experience, management strategies, and outcomes. The theory has potential to improve outcomes and lower costs of chronic disease management with telemonitoring by allowing remote communication between patients and providers about symptoms and management strategies. Modifications may be needed to account for the telemonitoring context and its impact on communication, feedback, and adherence.
The document discusses the current state and expected growth trends of the in vitro diagnostics (IVD) market. It notes that the global IVD market was estimated at $54.2 billion in 2013 and is expected to grow 4% annually to $64.3 billion by 2018. Technological advances in areas like genomics, bioinformatics, and miniaturization have transformed diagnostic laboratory technology in recent years. Personalized medicine, infectious disease testing, and other applications are driving growth in the IVD market. However, economic instability, rising healthcare costs, and reimbursement changes pose challenges for the industry.
La insuficiencia renal aguda (IRA) se caracteriza por una disminución rápida de la función renal en horas o días. Puede ser pre-renal (60-70% de los casos), renal (20-30%) o posrenal (10%). La forma pre-renal ocurre cuando hay hipoperfusión renal y la estructura renal se mantiene normal. Los síntomas incluyen oliguria, aumento de productos nitrogenados en sangre y disminución de la diuresis. El tratamiento se enfoca en corregir la causa subyacente y mejorar el flujo s
Mark Haas Kidney Summary Banff 2013 in Brazil Kim Solez ,
Kidney summary from 12th Banff Conference on Transplant Pathology from the meeting in Comandatuba-Bahia, Brazil on August 23rd, 2013 http://cybernephrology.ualberta.ca/banff/2013
Este documento proporciona información sobre el virus BK (BKV), un poliomavirus humano. Describe que el BKV es la causa más común de nefropatía viral en receptores de trasplante renal. Explica que la primoinfección por BKV generalmente ocurre en la infancia y que el virus permanece latente en el riñón y las vías urinarias. Tras la inmunosupresión por un trasplante renal, el BKV puede reactivarse y causar nefropatía, lo que puede conducir a la pérdida
JerusalemL practical immuno for hepatobiliary neoplasiaNeil Theise
This document discusses immunohistochemistry markers that can be used to differentiate various hepatobiliary neoplasms and lesions. It begins with an overview of markers that can help distinguish benign from malignant hepatocytes, such as CD34 and reticulin staining. The document then covers marker panels useful for specific diagnoses, such as distinguishing hepatocellular carcinoma from metastatic tumors. Several case examples are presented to demonstrate the application of immunohistochemistry in accurately diagnosing difficult hepatobiliary cases.
Este documento describe la historia y las partes de dos tipos de microscopios electrónicos: el microscopio electrónico de transmisión (TEM) y el microscopio electrónico de barrido (SEM). El TEM emite un haz de electrones hacia el objeto para aumentarlo, mientras que el SEM barre la superficie de la muestra punto por punto con electrones de un cañón. Ambos microscopios pueden utilizarse para estudiar la morfología de una variedad de materiales a nivel microscópico y nanoscópico.
Methotrexate is an antifolate drug that inhibits dihydrofolate reductase (DHFR), blocking the production of nucleotides needed for DNA synthesis. It is used to treat cancers like acute lymphoblastic leukemia as well as autoimmune diseases like rheumatoid arthritis. Methotrexate is transported into cells and polyglutamated, increasing its intracellular activity and half-life. It causes cell death by inhibiting DNA synthesis and inducing strand breaks. Resistance can develop through reduced polyglutamation, increased DHFR levels, or drug efflux pumps. The cytotoxic effects of methotrexate are S-phase specific and depend on drug concentration and duration of exposure.
This white paper has elicited views from a broad group of
industry parDcipants about the future of the Biosciences
industry in Singapore. It provides themes that can help to
guide the development of innovaDve ideas to propel the next
lap of Biosciences growth in Singapore.
El documento compara los microscopios electrónico y de luz, explicando que el electrónico permite mayores aumentos y resolución al usar electrones en lugar de luz. Describe los componentes y usos del microscopio electrónico de transmisión y de barrido, incluyendo la formación de imágenes y señales generadas.
This article features an exclusive interview with an artist, including a quotation relating to the interview. It also includes a main image of the artist as well as smaller additional images of the artist.
O Espaço Peon Guimarães oferece treinamento individualizado em horários específicos nas segundas, terças e quartas nas piscinas grande e pequena, com opções entre 07:55, 14:55, 16:00 e 16:45.
El documento contiene varias noticias relacionadas con Oaxaca, México. Incluye una historia sobre la promesa incumplida del gobernador de crear una secretaría ambiental, otra sobre las anomalías encontradas por la Auditoría Superior de la Federación en el uso de fondos federales por el estado de Oaxaca, y una más sobre un paro de trabajadores del IMSS exigiendo mejoras salariales y medicamentos.
The document discusses the pros and cons of implementing electronic health records (EHRs) in hospitals and healthcare facilities. Some key benefits discussed include improved data accessibility, computerized physician order entry, improved charge capture, and opportunities for preventative health screenings. However, the document also notes several challenges, such as increased time spent on documentation, costs of setup and maintenance, decreased productivity during implementation, and issues with a lack of interoperability between different EHR systems. Overall, the document provides an overview of the debate around whether the benefits of EHRs outweigh the drawbacks.
3 ways fragmented clinical communication is compromising patient carePatientSafe Solutions
1. Patient care is delayed due to inefficient systems and workflows
2. Multi-device digital communication complicates critical context
3. Unmanaged use of personal smartphones jeopardizes PHI security
European Pharmaceutical Review: Trials and Errors in NeuroscienceKCR
This document discusses several challenges of conducting clinical research in neuroscience. It notes that while interest and publications in neuroscience have increased, the nervous system remains the least understood part of the human body. Conducting global clinical trials in neuroscience poses difficulties due to variations in where patients can be found, standards of care between countries, and restrictions on access to modern therapies. The document also outlines problems with using complex questionnaires in trials and inconsistencies in how patients perceive and report their symptoms.
The value of real-world evidence for clinicians and clinical researchers in t...Arete-Zoe, LLC
In the midst of a rapidly spreading global pandemic, real-world evidence can offer invaluable insight into the most promising treatments, risk factors, and not only predict but suggest how to improve outcomes. Despite overwhelming news coverage, significant knowledge gaps regarding COVID-19 persist. The current uncertainties regarding incidence and the case fatality rate can only be addressed by widespread testing. But the paucity of testing, and diversity of approaches implemented in different countries, particularly among the general asymptomatic public, perpetuates a lack of understanding about spread and infectivity. The essential indicators that would describe the pandemic more accurately can be obtained using real-world data (RWD). To that purpose, we designed a data collection tool to collect data from hospitals that treat COVID-19 patients. The captured data will enhance our understanding of the COVID-19 pandemic, identify risk factors relevant for triage, relate to other similar seasonal infections and gain insight into the safety and efficacy of experimental and off-label therapies. Knowledge derived from a focused data collection effort will enable clinicians to adjust rapidly clinical protocols and discontinue interventions that turn out to be ineffective or harmful. By deploying our elegantly designed survey to capture routine clinical indicators, we avoid placing an additional burden on practitioners. Systematically generating real-world evidence can decrease the time to insight compared to randomized clinical trials, improving the odds for patients in rapidly changing conditions.
This document discusses Symptom Management Theory (SMT), a nursing theory that explains the interaction between a patient's symptom experience, symptom management strategies, and outcomes. The theory has potential to improve chronic disease management using telemonitoring. Telemonitoring allows remote monitoring of patient symptoms and communication with providers, which could guide self-management according to SMT's conceptual domains of symptom experience, recommended strategies, and evaluation of outcomes. The document reviews SMT and proposes it as a framework to inform telemonitoring intervention design.
Symptom Management Theory (SMT) developed at UCSF explains the interaction between symptom experience, management strategies, and outcomes. The theory has potential to improve outcomes and lower costs of chronic disease management with telemonitoring by allowing remote communication between patients and providers about symptoms and management strategies. Modifications may be needed to account for the telemonitoring context and communication changes.
Symptom Management Theory (SMT) developed at UCSF explains the interaction between symptom experience, management strategies, and outcomes. The theory has potential to improve outcomes and lower costs of chronic disease management with telemonitoring by allowing remote communication between patients and providers about symptoms and management strategies. Modifications may be needed to account for the telemonitoring context and its impact on communication, feedback, and adherence.
The document discusses the current state and expected growth trends of the in vitro diagnostics (IVD) market. It notes that the global IVD market was estimated at $54.2 billion in 2013 and is expected to grow 4% annually to $64.3 billion by 2018. Technological advances in areas like genomics, bioinformatics, and miniaturization have transformed diagnostic laboratory technology in recent years. Personalized medicine, infectious disease testing, and other applications are driving growth in the IVD market. However, economic instability, rising healthcare costs, and reimbursement changes pose challenges for the industry.
How Tele-Medicine Helped and provide support to the healthcare systems, particularly in the areas of public health, prevention, and clinical practices, just as it is doing in other sectors. One of the most important strategies to reduce and mitigate the advance of the epidemic is social distance measures
1) The home health care market in the US has potential to grow but faces many financial and operational barriers holding it back.
2) New technologies like remote patient monitoring and telemedicine are bringing advanced care into patients' homes but have low penetration due to misaligned incentives between payers and providers.
3) For a technology-enabled home care business model to succeed, it must satisfy financial, effectiveness, and accessibility factors - including having a clear value proposition, impacting patient outcomes, being easy to use, and integrating with clinical workflows.
Twenty-first century technologies will create significant opportunities and challenges for all healthcare stakeholders. Pharmacovigilance (PV) too is in transition, with new sources of medical information and methods for its analysis that will transform today's largely reactive system into proactive benefit-risk management for all medication users.
This document summarizes a quality improvement project at a large oncology practice to reduce the response time for symptom management calls. The project team implemented a case management system, reallocated nursing staff, and developed standardized protocols. These changes increased the percentage of symptom management calls receiving a clinical intervention within 2 hours from 54% at baseline to 73% after implementation. The number of non-clinical calls reaching the triage nurse also decreased significantly. The case management system provided data to identify additional opportunities for improvement beyond triage response times.
This document provides a vision for the future of hospitals in 10 points:
1. Hospitals will be smaller and more specialized, with fewer overall beds and more focus on severe acute illnesses.
2. Hospitals will have a more user-friendly, hotel-like design with improved patient amenities and autonomy.
3. Staff numbers will be reduced through increased automation, telemedicine, and remote monitoring, but patient care levels will be maintained.
4. Telemedicine, robots, and other technologies will play a larger role in tasks like delivery, transport, and rehabilitation to increase efficiency.
5. Patients will be mobilized earlier and continuously monitored both in the hospital and after discharge through remote technologies.
Health care consumers benefit from understanding some of the issues involved in providing them with the best care, and some things they can do themselves to prepare for and learn about these issues. Doctors, nurses, and other health professionals dedicate their lives to caring for their patients. But providing health care can be complicated.
The document discusses several topics related to imaging in healthcare:
1) Stage 2 MU requirements call for remote viewing of patient records and images to increase access for physicians and patients. Patient portals may play a larger role in remote monitoring programs for chronic conditions.
2) Clinical decision support and CPOE are now required to improve safety, eliminate errors, and justify expensive tests. VNAs can enable remote access via mobile devices.
3) The future is moving from hospital-centric, episodic, fee-for-service care to being more patient-centric, continuous, and value-based with an emphasis on wellness in addition to sickness.
4) Data liquidity, or ensuring the
This document discusses three key problems with the current state of clinical communication: 1) fragmented communication across multiple devices wastes up to 91 minutes per day of clinicians' time, 2) the lack of context in digital messages can compromise patient care, and 3) unmanaged use of personal devices for work purposes jeopardizes protected health information security and could result in large fines. It argues that a streamlined, context-aware communication solution is needed to address these problems and improve patient care.
The Patient Journey Record System (PaJR) uses lay care guides to remotely monitor patients with chronic illnesses through daily phone calls. The calls analyze patients' health and social situations to predict health risks and chances of hospitalization. PaJR has completed Phase 1, comparing hospitalization rates between monitored patients and controls. Phase 2 is an ongoing regional trial monitoring over 130 patients. Preliminary results show the control group has approximately 3 times higher unplanned admission rates. PaJR aims to detect health issues earlier to reduce avoidable hospitalizations through low-cost monitoring and support.
The Patient Journey Record System (PaJR) uses lay care guides to remotely monitor patients with chronic illnesses through daily phone calls. The calls analyze patients' health and social situations to predict health risks and the need for hospitalization. PaJR has completed Phase 1, which found lower hospitalization rates among monitored patients compared to controls. Phase 2 is ongoing in two sites and continues to recruit more patients and controls. Preliminary results again show lower admission rates for monitored patients. The system aims to detect health issues earlier through closer monitoring to reduce avoidable hospitalizations and shift care to the community.
Similar to Kim Solez Shedding new light on education at biopsy rounds (20)
Kim Solez The Ethics of Pig to Human Transplants, Artificial Intelligence, an...Kim Solez ,
Kim Solez is an internationally renowned renal transplant pathologist and educator with over 30 years of experience. He has trained numerous students and published over 230 journal articles. Solez is passionate about advancing regenerative medicine through techniques like xenotransplantation and stem cell-generated organs to address the massive organ shortage. He believes artificial intelligence can help solve some of the complex challenges in making these approaches successful at scale.
Kim Solez DALL-E and Kidney Pathology Machine Fantasies Give Hint About What...Kim Solez ,
The document discusses the author's experience using DALL-E, an AI image generation model, to try generating images related to kidney pathology. The author notes that every prompt results in negotiation with DALL-E, as it has rules to prevent harmful outputs. The author imagines that future versions of DALL-E may be able to generate high-quality pathology images. The document also shares stories about the author's past work with the National Kidney Foundation and an artist named Philippe Hebert.
Kim Solez Clinical Trials, Fundamental DIscoveries and Teaching Renal Transpl...Kim Solez ,
This document discusses the history and importance of tubulitis as a marker for acute T cell-mediated rejection (TCMR) in kidney transplant biopsies. It notes that Kim Solez first described tubulitis in 1985 in biopsies from a cyclosporine-treated protocol study. Tubulitis was later recognized as a crucial finding in the original 1993 Banff Classification article. The specificity of tubulitis for acute TCMR has made it a long-standing focus of morphometric analysis and machine learning in digital pathology. The success of identifying tubulitis has led to its continued importance in evaluating rejection over decades of clinical trials and transplant pathology practice.
Kim Solez How AI can improve human cooperation through suggesting followup ac...Kim Solez ,
The document discusses countering the idea of "AGI ruin", where artificial general intelligence makes humans obsolete. It suggests that instead of ruin, AGI could lead to unprecedented global cooperation that improves humanity. The best way for beneficial, cooperation-enabling ideas from AI to emerge is through a new type of large language model that possesses a true understanding of the world. Such an AI invention could win a Nobel Peace Prize if it helps increase human cooperation and avoids the lethal outcomes feared by some in the AI safety community.
Kim Solez How AI can improve human cooperation through suggesting followup ac...Kim Solez ,
The document discusses the potential outcomes of artificial general intelligence (AGI), including Eliezer Yudkowsky's idea of "AGI ruin" where humans become obsolete. However, AGI could also lead to greater global cooperation that improves humanity. The best way for AI to generate ideas to help human cooperation would be through large language models that have a true understanding of the world. This could help avoid the worst outcomes of AGI and instead create a more positive future of improved human cooperation.
Slide deck for annual meeting of Transplant Regenerative medicine Community of Practice of American Society of Transplantation at noon in Room 204 in John B. Hynes Convention Center. Everyone welcome! Many exciting initiatives to discuss!
Kim Solez Xenotransplantation- The Rest of the Story April 8 2022 6.pptxKim Solez ,
Nephrology Grand Rounds Presentation at the University of Alberta discussing the big picture issues surrounding xenotransplantation and its relation to stem cell generated organs and bioengineered organs in the future
Kim Solez Hooking-Up Physical Forces Optimism and Dark Energy Presentation Se...Kim Solez ,
Kim Solez Banff New Media Institute Presentation, "Smart, Sexy, Healthy" ThinkTank, Sept 6 2001
Hooking-Up, Physical Forces, Optimism and Dark Energy: Imagery, Hope, and Health.
Kim Solez combining resources in tx and regen med make no small plansKim Solez ,
This document discusses the future of combining regenerative medicine and transplantation through three main points:
1. Regenerative medicine promises to address longstanding limitations of organ transplantation by providing an inexhaustible source of organs, immunosuppression-free transplantation, and organs on demand.
2. Transplant pathologists are becoming tissue engineering pathologists and playing a role in regenerative medicine through organizations like Banff conferences.
3. A First World Congress of Regenerative and Transplant Medicine is being planned to bring together organizations in these fields to discuss their common future, with the goal of having the meeting in Boston in April 2021.
Solez Yagi Farris Barisoni Digital transplant pathology white paper2Kim Solez ,
This document discusses several digital pathology projects being conducted by Yukako Yagi and her team at Memorial Sloan Kettering Cancer Center. These include developing automated analysis of fluorescence in situ hybridization (FISH) images using deep learning, generating 3D digital images of whole tissue blocks using micro-computed tomography, and evaluating the use of multiplex immunofluorescence staining compared to double immunohistochemistry staining. The goal is to advance computational pathology through innovative applications of digital pathology techniques.
Kim Solez Yukako Yagi Digital transplant pathology white paper1Kim Solez ,
This document discusses digital transplant pathology and proposes initial projects for a working group. It describes how digital pathology can help address declining interest in pathology as a specialty. Only 25 pathology departments were fully digitized in 2018, rising to 30 in 2019. The percentage of US pathology trainees who are US medical graduates has declined in recent years. The document proposes that the working group focus on practical examples and first projects involving digital transplant pathology.
Kim Solez Yukako Yagi Digital transplant pathology white paperKim Solez ,
This document discusses digital transplant pathology and proposes initial projects for a working group. It begins with background on digital pathology and its potential to address declining interest in pathology. Only 30 of over 1000 pathology departments worldwide were fully digitized in 2019. The document then discusses exponentially advancing technologies and influential figures in the field. It proposes that the working group focus on practical digital pathology examples and first projects related to transplant pathology. One such example discussed is automated fluorescence in situ hybridization (FISH) quantification from whole slide images using deep learning.
Kim Solez 384 years of banff spirit new june 26 2019Kim Solez ,
Kim Solez 384 years of Banff spirit new June 26 2019 The most remarkable slide is number 137. "By Spring of 2019 every erroneous statement we complained about had been reversed. We celebrated by creating a new video trailer on our YouTube channel on June 25 2019." How about that!
Kim Solez C3 GN case with 6-8 nm fibrils Congo Red negative Part IIKim Solez ,
The needle core biopsy of the patient's left native kidney showed C3 glomerulopathy with a membranoproliferative glomerulonephritis pattern, which is a form of glomerulonephritis where there is proliferation of cells and increased thickness in the glomerular basement membrane of the kidney.
Kim Solez C3 GN case with 6-8 nm fibrils Congo Red negative Part IKim Solez ,
A 49-year-old female presented with decreased C4 and normal C3 levels. A kidney biopsy showed strong mesangial and vascular staining for C3 on immunofluorescence, but was negative for IgG, IgA, IgM, C1q, kappa, lambda, and albumin. This suggests a diagnosis of C3 glomerulopathy.
Kim Solez shortened slide set for opening reception Pittsburgh Banff meetingKim Solez ,
This document provides a timeline of events and influences in Kim Solez's life and career from 1895 to 2099:
- It outlines the origins of Kim's beliefs in gender and diversity from childhood experiences in the 1940s and highlights various mentors and influences over her career in nephrology pathology.
- Key developments include initiating the Banff Classification of Transplant Pathology in 1991 and directing digital pathology, artificial intelligence, and regenerative medicine research efforts to transition the field into the future.
- The timeline shows Kim's work to establish the future of nephrology through innovations in education, collaborations, and applying emerging technologies like digital pathology and artificial intelligence.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Hiranandani Hospital in Powai, Mumbai, is a premier healthcare institution that has been serving the community with exceptional medical care since its establishment. As a part of the renowned Hiranandani Group, the hospital is committed to delivering world-class healthcare services across a wide range of specialties, including kidney transplantation. With its state-of-the-art facilities, advanced medical technology, and a team of highly skilled healthcare professionals, Hiranandani Hospital has earned a reputation as a trusted name in the healthcare industry. The hospital's patient-centric approach, coupled with its focus on innovation and excellence, ensures that patients receive the highest standard of care in a compassionate and supportive environment.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
6. Today we present two cases
where physician-provided
information contained only in
an Email or a phone call
determined in large part the
final diagnostic possibilities.
Iconic images!
7. Capturing such information
(not in the final report) in an
easily retrievable, verifiable, and
digital way would be a valuable
addition to clinical patient care
.
8. Allowing modern secure
digital communications
between pathologist and
clinician re. biopsy would
improve timeliness and
accuracy of reporting.
9. It could also contribute to new
initiatives like province wide
GN registry, and make
communication between
clinician and pathologist easier
and more rewarding.