Kimberly Carter evaluated the efficacy of multivalent virus-like particle (VLP) antigens in enzyme-linked immunosorbent assays (ELISAs) for detecting antibodies against infectious bursal disease virus (IBDV) strains. Multivalent VLPs containing VP3, a classic strain pVP2, and a variant strain pVP2 were produced. ELISAs using these antigens yielded positive results at low serum dilutions but not higher dilutions. Antigens containing a single VP3 and pVP2 appeared more effective. While multivalent VLP ELISAs showed some ability to detect antibodies, commercial ELISA kits still need testing for superior performance.