Hemoglobin is broken down through erythrocyte lysis, releasing its components of globin amino acids, iron, heme, and porphyrin. Heme is further broken down by heme oxygenase into biliverdin and then bilirubin, releasing carbon monoxide and iron in the process. This overview summarizes the biochemical catabolism of hemoglobin and heme.

1. Katabolisme Hemoglobin

2. Eritrosit Lisis
Globin As Amino Penyusunnya
Hb Lisis
Besi (Fe2+)
Heme
Porfirin, CO
hemeoxigenase
Biliverdin
Bilirubin

3. Katabolisme tinjauan Biokimia
Heme
RES
α OH
α Fe3+ CO (exhalasi)
NADPH NADP NADPH NADP
Fe3+ Fe2+ Fe3+
O2
O2
Hemin Heme Hemin

4. Katabolisme Heme cont’d
NADPH NADP
H-H
biliverdin bilirubin